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Granulomatosis with polyangiitis (Wegener's granulomatosis):Three pathologic hallmarks of are granulomatous inflammation, vasculitis, and necrosis.Classic triad of upper and lower respiratory tract disease and glomerulonephritis.The histopathologic hallmarks of granulomatosis with polyangiitis are necrotizing vasculiti...
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Hemorrhage
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Ans. is 'd' i.e., Decreased pH
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Answer- C. Macular edemaReduced nonproliferative and proliftrative retinopathyMicroalbuminuriaClinical nephropathyNeuropathyImproved glycemic control
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Ans. is 'a' i.e., HDL o Lecithine-Cholesterol acetyltransferase (LCAT) esterifes cholesterol in HDL during reverse cholesterol transport,o All nucleated cells in different tissues synthesize cholesterol, but the excretion of cholesterol is mainly by liver in the bile or by enterocytes in gut lumen. So, cholesterol must...
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Ans. is 'b' i.e., Herpes `Herpes simplex (in the developed world) and chancroid (in Africa) are the most common cause of genital ulceration in HIV infected patients.' - 'An Atlas of differential diagnosis in HIV disease' by Lipman, Gluck and Johnson 1st (1995) p. 30
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Ans. is a i.e. TESA Friends, we have studied in detail IVF and IUI but either of them cannot be performed if appropriate methods for sperm recovery are not available in cases of male infeility. Sperm retrieval or Recovery can be done by : Microsurgical Epididymal Sperm aspiraton : MESAdeg Percutaneous Epididymal Sperm ...
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Sponging, paracetamol ibuprofen ,intermittent diazepam are treated for febrile seizures Most children with typical febrile seizures do not require specific treatment except for vigorous antipyretic therapy during febrile illnesses. Children experiencing excessively frequent or prolonged febrile seizures may be treated ...
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An infarct is an area of ischemic necrosis caused by occlusion of the vascular supply to the affected tissue Infarcts are classified on the basis of their colour into Red infarct with venous occlusions in loose tissues eg:- lung in tissues with dual circulations such as lung and small intestine, in previously congested...
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Ans. All are true
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The concentration of magnesium in serum is closely regulated within the range of 0.7–1 mmol/L (1.5–2 meq/L; 1.7–2.4 mg/dL), of which 30% is protein-bound and another 15% is loosely complexed to phosphate and other anions. One-half of the 25 g (1000 mmol) of total body magnesium is located in bone, only one-half of whic...
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NaSSA * IMPOANCE Nor adrenergic and specific serotonergic antidepressant * MECHANISM * Alpha 2 adrenergic receptor antagonism=== increase serotonin and NA * 5HT2,3 antagonist============increase sleep and appetite * DRUGS miazapine * USE Elderly with depression * SIDE EFFECTS hyperlipidemia re. kaplon and sadock, synop...
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Vaccine Strains Dengue/Dengavaxia : CYD-TDV BCG : Danish 1331 Measles : Edmonston Zagreb Mumps : Jeryl Lynn Rubella : RA 27/3 YF : 17D Varicella : Oka JE : SA 14-14-2 H1N1 : A7/California/2009 Mosquirix : S,S/AS01 (World's first & only licensed malaria vaccine. It is prepared from circumsporozoite protein of plasmodium...
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Hairy male Army Serous discharge Pilonidal sinus Pilonidal sinus - Acquired - M/C in hairy males, Army personnel - Cyst in - Post-natal cleft region - Cyst - Contains hair - Sinus - Abscess formation due to tract blockage - Hair follicles have not seen in the walls of the sinus. - The hairs projecting from the sinus ar...
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Ans. is 'c' i.e., Sulph - meth hemoglobin Signs of putrefaction The signs and effects of putrefaction are as follows :? 1. Colour changes The earliest sign of decomposition is greenish discoloration of body, seen in right iliac fossa externally and under liver internally. This is due to involvement of caecum. Which con...
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Ans. is 'c' i.e., Cl?Among the given options, Cl- has lowest permeability coefficient and maximum permeability.Permeability of membraneAs the major middle poion of membrane (core of the membrane) is formed by hydrophobic region of phospholipids, this poion is impermeable to the usual water-soluble substances, such as i...
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Lithium has to be stopped 24 hrs prior to surgery.
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Ans. is 'b' i.e., 30 minuteso The metabolic rate of the hea is high, and its stores of substrate are low.o So, hea is critically dependent on a continuous supply of oxygen and nutrients.o Ischemia of myocardium induces profound functional, biochemical and morphological consequences.o Myocardial function is more sensiti...
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<p>In case of anemia of chronic disorder, anemia is not related to bleeding ,hemolysis or marrow infiltration,is mild,with normal MCV (normocytic normochromic) though this may be reduced in long standing inflammation .</p><p>Reference :Davidson&;s principles &practice of medicine 22nd edition pg no 1023.</p>
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Protein buffers in blood include haemoglobin (150g/l) and plasma proteins (70g/l). Buffering is by the imidazole group of the histidine residues which has a pKa of about 6.8. This is suitable for effective buffering at physiological pH. Haemoglobin is quantitatively about 6 times more impoant than the plasma proteins a...
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ref : kd tripathi 8th ed
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Propylthiouracil, carbimazole and methimazole act by inhibiting the enzyme, thyroid peroxidase. It catalyses: Oxidation of iodine Organification Coupling
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SRBs manual of surgery,4th edition According to parkland regimen, 4ml/%burn/bodyweight/24hours. i.e 4*45*50=9000ml. Fluid requirements, first 24hours=9L first 8hours=4.5L 4.5L are infused in the next 16hours Hartmann's solution or ringer lactate is recommended Regular assessment of the adequacy of resuscitation shoul...
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Ans. is 'b' i.e., CBC,reti count with peripheral smear In above question, if child is stable, then no need to give blood transfusion. Before staing Iron, we have to rule out types of anemia as Iron is indicated only in nutritioral anemia. Hb ele ctrophoresis is indicated if there is featuer of hemolytic anemia (thalass...
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D. i.e. Inferior oblique
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Burkholderia spp:Burkholderia malleiBurkholderia pseudomallei--Non motile bipolar stained organism --On Potato - Honey like growth--Class B agent of biological warfare --Induces Strauss reaction--Diagnosis - Mallein test & Molecular methods by 16s rRNA gene sequencing --Rx - Ceftazidime or Carbapenems --Causative agent...
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Ans. (d) PathogenesisThe causative factors of disease include AGENT, HOST, ENVIRONMENT . These 3 are referred as Epidemiological triad. Interaction of these 3 factors is required for development of disease .
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Irrigation of the cul de sac can reduce the halos in conjunctivitis Halos due to immature senile cataract are broken by slit (Fincham test) Halos due to corneal edema in glaucoma is reduced by decrease in IOP
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Posterior pa
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Answer is A(Anti-Jo-1): Anti-Jo-1 Antibodies (Antibodies to histidyl - tRNA) are the most common and most clinically assayed Myositis Specific Antibodies (MSA) Myositis Specific Antibodies (MSA) Myositis Specific antibodies are autoantibodies, usually directed against intracellular ribonucleoproteins that are involved ...
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(5000 rads) (2588-H 15th)OrganInjuryMinimum tolerance doseMaximum tolerance doseWhole or partial organ(Field size or length)Bone marrowAplasia250450Whole Pancytopenia300004000SegmentalLiverAcute hepatitis25004000*Whole Chronic hepatitis15002000Whole (Strip)StomachPerforation, ulcer, hemorrhage45005500100 cmIntestineUlc...
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Ans. is 'a' i.e., Group A Streptococci Rheumatic fevero Rheumatic fever (RF) is an acute, inununologically mediated, multisystem inflammatory disease classically occurring a few weeks after an episode of group A streptococcal pharyngitis; occasionally, RF can follow streptococcal infections at other sites, such as the ...
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Proto-OncogeneAssociated tumorKRASColon, lung, and pancreatic tumorsBRAFMelanomas, leukemias, colon carcinoma, othersRETMultiple endocrine neoplasia 2A and B, Familial medullary thyroid carcinomasKITGastrointestinal stromal tumors, seminomas, leukemiasRef: Robbins and Cotran Pathologic Basis of Disease; 9th edition; Ch...
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Pathogenesis of HIV infection and AIDS Primary infection of cells through the blood and mucosa. The initial entry of the virus may be through a mucosal surface, as in sexual intercourse (via rectal or cervical mucosa) or via blood exposure e.g. (after intravenous drug abuse). From the mucosa the virus is carried to t...
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Abreaction is a process by which repressed material is remembered back, relived again along with expression of associated emotions. It is a type of Catharasis (purging of emotions) used as therapy in few psychiatric disorders.
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Inclusion body in case of psittacosis is Levinthalcole Lillie. HP body:-seen in case of trachoma Miyagawa corpuscles:-LGV Henderson Peterson:-molluscum contagiosum
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Adenomyosis is characterised by myometrial cyst, which is most specific sign.
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In case of superimposed bacterial infection, coagulative necrosis is modified by the liquefactive action of the bacteria and the attracted leukocytes (resulting in so-called wet gangrene)
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Elution is found only in viruses that possess neuraminidase REF:ANANTHA NARAYANAN MICRO BIOLOGY NINTH EDITION PAGE.430
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Tension Pneumothorax :- Reduced blood supply to lungs | Affected lung has collapsed and contralateral lung will not be able to do the work of both the lungs. | This results in carbon dioxide retention ultimately leading to Respiratory Acidosis
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Ans. is 'd' i.e., All the above * ARF with urine output > 600 ml/day is defined as non-oliguric renal failure-* Important drugs cousing non-oliguric renal failure are -i) Aminoglycosides (e.g. gentamycin)iv) Ifosfomideii) Amphotericin Bv) Radiocontrast agentsiii) Cisplatinvi) Cyclosporine
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Ans. is 'd' i.e., Beta-2 receptor stimulationo Pneumonia and CHF (Cardiopulmonary disease) require dose reduction (not increased dose).Theophyllineo Theophylline is one of the three naturally occurring methylated xanthine alkaloids (methyl xanthines) - Caffeine, theophylline and theobromine,o Mechanism of actiona) Inhi...
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Ans. is 'a' i.e., Elective open cholecystectomy for cholelithiasis
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Cp - > Cp/2 in 1 half-life i.e. 50.0 % lost 50.0 % Cp - > Cp/4 in 2 half-lives i.e. 25.0 % lost 75.0 % Cp - > Cp/8 in 3 half-lives i.e. 12.5 % lost 87.5 % Cp - > Cp/16 in 4 half-lives i.e. 6.25 % lost 93.75 % Cp - > Cp/32 in 5 half-lives i.e. 3.125 % lost 96.875 % Cp - > Cp/64 in 6 half-lives i.e. 1.563 % lost 98.438 %...
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Ans. is 'b' i.e., Niacin
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MEN 1 is an autosomal dominant disorder due to a defect in 11q13, which encodes for a 610-amino-acid nuclear protein, menin. Patients with MEN1 develop hyperparathyroidism due to parathyroid hyperplasia in 95-100% of cases, pituitary adenomas in 54-80%, adrenal adenomas in 27-36%, bronchial carcinoids in 8%. Ref: Harri...
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. t(9:22), t(8:14), t(4:11)
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Digoxin is primarily eliminated unchanged by glomerular filtration Digitoxin is eliminated by hepatic metabolism.
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Winged scapula is caused by paralysis of the serratus anterior muscle that results from damage to the long thoracic nerve, which arises from the roots of the brachial plexus (C5-C7)
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In the small intestine, Paneth cells residing at the bottom of the intestinal crypts are the key effectors of innate mucosal defense. -Paneth cells provide host defense against microbes in the small intestine. They are functionally similar to neutrophils. -Paneth cells secrete a number of antimicrobial molecules into t...
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Ans. D i.e. H. pylori Peptic ulcer/Peptic ulcer disease It is defined as mucosal erosions equal to or greater than 0.5 cm. As many as 70-90% of such ulcers are associated with Helicobacter pylori, a helical-shaped bacterium that lives in the acidic environment of the stomach. Four times as many peptic ulcers arise in t...
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• Meta-analysis (Highest clinical relevance: GOLD STANDARD) • Systematic review • Cohort study • Case control study • Case series • Case report • Ideas, Editorials, Opinions • Animal research • In-vitro (test-tube) research (Lowest clinical relevance)
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Ans. is 'b' i.e., 0.0475 inch o The best pattern of mosquito net is the rectangular net.o There should not be a single rent in the net.o The Size of openings in the net is of utmost importance, the size should not exceed 0.0475 inch in any diameter.o The number of holes in one square inch in usually 150.
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Ans. is 'b' i.e., beta-Blocker Drugs causing hvperiglyceridemia ? o Estrogen o Furosemide o Bile acid - binding resin o HIV protease inhibitors. o beta-blockers o Glucocoicoids o Retinoic acid
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Bimolar technique or Gardner's view shows the lateral oblique view of the right and left halves of the jaw in the same radiograph. The 1st exposure is done of one side (right/left), while covering the other half of the cassette with a lead shield with the conventional technique for the lateral oblique view of the mandi...
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(D) All of the above # Genetic Hypothesis: The life-time risk for the first degree relatives of bipolar mood disorder patients is 25%, and of recurrent depressive disorder patients is 20%.> The life-time risk for the children of one parent with mood disorder is 27% and of both parents with mood disorder is 74%.> The co...
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Adenylyl cyclase is a transmembrane protein, and it crosses the membrane 12 times. Ten isoforms of this enzyme have been described and each can have distinct regulatory propeies, permitting the cAMP pathway to be customized to specific tissue needs. Notably, stimulatory heterotrimeric G proteins (Gs) activate, while in...
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At T8 - IVC hiatus in central tendon through which IVC and few branches of Rt. phrenic nerve passes At T10 - Oesophageal opening is present through which passes: Esophagus Esophageal branch of left gastric aery Anterior and posterior vagal trunk At T12 - Aoic hiatus posterior to diaphragm formed by median arcuate ligam...
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Ans. is 'a' i.e., 376Laws related to rapeo 375 - Define rapeo 376- Lays down the punishment for offence of rape which may extend from 7 years to life imprisonment and also fine unless the victim is his ow n w ife and is not under 12 years, if raped woman is his own wife (but not under 12 years) the imprisonment may ext...
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Ans. is 'a' i.e., Calcitonin The cells of medullary carcinomas, similar to normal cells, secrete calcitonin. In some instance other hormones are secreted such as somatostatin, serotonin, and VIP. Medullary carcinoma thyroid Accounts for approximately 7% of malignant tumour of thyroid. It arises from ultimobranchial bod...
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Ans. B: Pre senile
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Ans. is 'a' i.e., Hb < 11.5 gm/dl during 3rd trimester of pregnancy
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The rapid decline in dependency ratios has been associated with rapid economic development. Demographic bonus is the period when dependency ratio declines because of decline in feility until it stas to rise again because of increasing longevity. Ref: Park, 22nd edition pg: 446
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A variety of topical local anesthetic formulations have been developed to penetrate intact skin. EMLA, which is a eutectic mixture of 2.5% lidocaine base and 2.5% prilocaine base, is widely used for venipuncture, intravenous cannulation, skin grafting, and a range of other uses, including circumcision Ref: Miller's ane...
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Ans. is 'd' i.e., More than 1 year after cure Carriers Bacilli presist in the gall bladder or kidney and are eliminated in the feces (fecal carriers) or urine (urinary carrier), respectively. The development of the carrier state is more common in women and in older age groups ( over 40 yrs) Carriers are the more freque...
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ANSWER: (D) Medial cutaneous nerve of armREF: Schwartz 9th ed chapter 18, Bailey 25th ed page 733, Mastery of Surgery, Volume 1 edited by Josef E. Fischer, Kirby I. Bland, Mark P. Callery 5th ed Vol 1 page 323Virtually any part of brachial plexus can be injured in RND. Read following lines of Gray's anatomy.The medial ...
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Ans. is 'a' i.e. X-rays and Gamma-rays X-rays and gamma rays are electromagnetic waves with highest penetrating power.For deep seated tumours rays with maximum penetrating power is required so x-rays and gamma rays are used.Harrison 141h/e states - "Megavoltage X-rays are used to irradiate internal deep seated lesions ...
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Ans. is 'd' i.e., Stomach * GISTs are the most common mesenchymal neoplasm of gastrointestinal tract. GIST represents a distinct group of gastrointestinal tumors that originate from the interstial cells ofcajal which control gastrointestinal peristalsis.* GISTs can occur anywhere in the gastroinstestinal tract; the mos...
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Deficiency of Tyrosine Transaminase leads to Tyrosinemia type II Mnemonic: T + T = II T
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Ans. is 'b' i.e., Binding of inhibitor to other site and inhibition of enzyme Some enzymes, called allosteric enzymes, posses a site, in addition to substrate binding (catalytic) site, known as the allosteric site. Binding of allosteric modulator at the allosteric site affects the conformation of catalytic site. Such e...
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C i.e. Blood flow remains unchanged
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A i.e. Acute cholecystitis; B i.e. Mucosal thickening; C i.e. Cholesterosis
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Ans. is 'a' i.e., Autosomal dominant It is estimated that the combined incidence of mendelian inheritance (autosomal dominant, autosomal recessive, x-linked) in man is about 1% of all live born individuals. a As many as 793 autosomal dominant phenotypes. 629 autosomal recessive traits and 123 sex linked diseases have b...
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DIFFERENTIAL DIAGNOSIS OF NEONATAL SEIZURES Hypoxic ischemic encephalopathy → Most common cause (60%). Intracranial hemorrhage                        Hypoglycemia                                    Hyponatremia                                      Pyridoxine deficiency                          Drug withdrawal        ...
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Ans. D. Hirschsprung's diseaseAnorectal manometry should ideally be performed in all newborns with symptoms of lower bowel obstruction. This technique is useful in assessment of changes in anal pressure which are recorded during and after rectal distention. It is most helpful for diagnosing or excluding Hirschsprung's ...
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(c) Petrositis(Ref. Cummings, 6th ed., 2165)Since the air cells of the petrous bone communicate with the mastoid, in any patient, if there is persistent ear discharge following cortical or modified radical mastoidectomy, petrositis should be ruled out by CT and MRI. Also retroorbital pain is suggestive of petrositis (d...
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ACTIONS OF ACETAZOLAMIDE: i) Lowering of intraocular tension due to decreased formation of aqueous humor (it is rich in HC03). 2) Raised level of C02 in the brain and lowering of pH - sedation and elevation of seizure threshold. 3) Alteration of C02 transpo in lungs and tissues: - used in high altitude or mountain sick...
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Mc Ardle disease (Type V GSD) due to muscle phosphorylase deficiency is the most common GSD to present in adolescents & adults.
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The 1st line treatment regimens recommended by the CDC for uncomplicated infection in men and non pregnant women are Azithromycin 1gm single dose or Doxycycline 100 mg twice daily for 7 days. Ref: Kliegman, Behrman, Jenson, Stanton (2008), "Nelson Textbook of Pediatrics",; Chapter 223, "Chlamydia Trachomatis", Volume 1...
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Radioluscent lesion with surrounded sclerosis and pain relived by a salicylate are characteristic of Osteoid osteoma Refer Maheshwari 9TH ED p 235
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It is commonly occurring bursa between the fascia lata or superficial (transverse) prepatellar aponeurosis and the intermediate (oblique) prepatellar aponeurosis formed by the medial and lateral patellar retinacular layers (extensions of the vastus tendons) anterior to the patella A synol bursa (plural bursae or bursas...
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Ans. d (All of the above) (Ref. Sabiston I8,h / Table 34-17; H-17,h/Table 86-3)Endocrine-Active Agents Used in the Treatment of Breast Cancer ClassCommon examplesClinical use1Selective estrogen receptor modulators (SERMs)QTamoxifen, Raloxifene, ToremifeneAdjuvant therapy for metastatic disease2Aromatase inhibitors (AIs...
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Anterior relation of the right kidney -        Right suprarenal gland -        Liver -        The second part of the duodenum -        Hepatic flexure of the colon -        Small intestine   Anterior relation of the left kidney -        Left suprarenal gland -        Spleen -        Stomach -        Pancreas -        S...
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Answer is A (Inflammatory bowel disease): Enteropathic Ahis (Ahritis associated with inflammatory bowel disease) is a seronegative ahropathy that is characterized hr the absence of Rheumatoid factor. Causes of False Positive Rheumatoid factor SLE (Associated with a positive Coomb's test) Sjogren syndrome Chronic Liver ...
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Periungal fibroma is not included under diagnostic criteria for NF - 1.
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Zoster or shingles occurs due to reactivation of latent VZV present in the trigeminal ganglia that occurs mainly in adult life. Rashes are unilateral and segmental, confined to the area of skin supplied by affected nerves Ref: essentials of Medical microbiology apurba sastry 1st edition page 438
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Ans. is 'a' i.e., Sporothrix schenckii(Ref: Harrison, 18th/e, 1665; Jawetz, 23rd/e, p. 633-634)Series of ulcers in a row suggests the diagnosis of sporotrichosis.
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Ans. is 'b' i.e., Rubrospinal tract [Ref: Ganong 25th/e p. 241 & 24th/ep. 239-240* Pyramidal (corticospinal) tract and extrapyramidal tracts concerned with the muscles of the trunk and proximal portion of limbs (i.e., the muscle mainly concerned with the postural control) occupy anterior white column of spinal cord and...
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Ans. is `b > c > a' i.e., Primaquine > Quinine > Chloroquine o Among antimalarial drugs, primaquine, quinine and occasionally chloroquine can cause hemolytic anemia in G6PD deficiency. But, primaquine has the highest potential to cause hemolytic anemia in patients with G6PD deficiency and, the patients with G6PD difici...
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Propofol produces doses-dependent respiratory depression with apnea occurring in 25% to 35% patients after induction close. The ventilator response of co2 and apnea also reduces. They are potent bronchodilator. It preserves hypoxic pulmonary vasoconstriction. Blunts upper airway reflexes
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Conversion disorder is a neurosis. There are no delusions or hallucinations in neurosis.
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Acoustic neuromas are slow-growing tumors that can eventually cause a variety of symptoms by pressing against the eighth cranial nerve. Hearing loss in one ear (the ear affected by the tumor) is the initial symptom in approximately 90 percent of patients.
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D- Xylose absorption test: Mucosal disease in Small Intestine Fecal Fat animation: Steatorrhea Breath Hydrogen test: Carbohydrate malabsorption Urine aminoaciduria: Fanconi Syndrome
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Sternocleidomastoid muscle receives its blood supply from branches of occipital and posterior auricular arteries (upper part of muscle), the superior thyroid artery or branches of the external carotid artery (middle part of muscle) and the suprascapular artery (lower part of muscle) — Gray's - 441 Although the suprasca...
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Ans Ctomegaloviruys
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ANSWER: (B) Small cell cancerREF: Harrison's 18th ed chapter 89Prophylactic Cranial Irradiation:Prophylactic cranial irradiation (PCI) should be considered in all patients with LD (local disease) - and ED (extended disease)-Small cell lung cancer (SCLC) who has responded to initial therapy. A meta-analysis including 7 ...
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Large and/or small sharply defined radiolucencies may be present in the maxilla and/or mandible. Absence of the lamina dura and ‘ground-glass’ appearance of the bone.
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All 4 phases may be seen in different parts of the same lung Congestion (1-2 days) Red hepatization (2nd-4th day) Gray hepatization (5th-8th day) Resolution (8th-9th day)
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Otolith organs (present in maculae) are concerned with linear acceleration, gravity and head tilt movements and they also help to maintain static equilibrium.
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Ans- B Ref- Clinical manifestations Due to the lack of typical symptoms and signs, early-stage breast cancer (ESBC) is often neglected by patients and typically found during physical examination or breast cancer screening. The typical signs of breast cancer, as listed below, usually occur in the more advanced stages. 2...
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