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Ans. (b) IgM Ref. jawetz 25/e, p 130, 27/e p 98 IgM is the first antibody to be produced, after exposure to both antigen or allergin "IgM is the first antibody formed in every response" ...Medical Microbiology by BS Napoba Thogh ovaalbumin is an allergin, its initial injection would produce IgM first, then IgE. If it i...
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Most sensitive → Antinuclear antibody (ANA) Most specific → Anti-double stranded antibody and the antibody against Smith (Sm) Associated with neonatal lupus and congenital heart block → Anti Ro, Anti LA antibody Associated with lupus psychosis → Anti P antibody
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Astigmatism It is that condition of refraction wherein a point focus of light cannot be formed' upon the retina. It includes those anomalies in the optical system wherein an appreciable error is caused by the unequal refraction of light in different meridians. Hence it may be an error either of curvature, of centering ...
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Ans. is Gaucher Gaucher's o Autosomal recessive, o Deficiency of glucocerebrosidase. o Accumulation of glucosyl ceramides in cells of RES. o Spleen enlarged with S/o hypersplenism (leukopenia thrombocytopenia), o Liver enlarged, o Expansion of bone marrow. Tay sachs o Autosomal recessive, o Deficiency of hexosaminidase...
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. <p>INFLUENZA:- Influenza viruses classified under the family ohomyxoviridae. 3 viral subtypes-A,B and C. These three are antigenically distinct.No cross immunity between them. Influenza A and B - responsible for epidemics throughout the world. Influenza A has 2 distinct surface antigens- hemagglutinin(H) and neuramin...
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Ans. D: Unilateral pneumonitis
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A. i.e. HHV-7
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Ans. is 'd' i.e. Cancer in opposite breast Adverse effects of Tamoxifen: - Hot flushes, nausea vomiting (most common side effects)*Menstrual irregularities, vaginal bleeding, discharge, pruritus vulvae & dermatitisEndometrial cancerThromboembolismCataractsRetinal deposits & decreased visual acuityUses of Tamoxifen: -Es...
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Unstable relationships suicidal attempts & mood swings are suggestive of Borderline personality disorder.
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Sodium hypochlorite: Sodium hypochlorite a compound of chlorine is the best disinfectant for surface blood spills, with a concentration of 0.5- 5%. 0.1% Hypochlorite - To disinfect colonized/infected pt. bed in isolation room after cleaning with detergent for 10 mins. 1% Hypochlorite - For decontamination of suction ja...
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Robbins basic pathology 9th edition, page no:46 Platelets contain the enzyme thromboxane synthase producing thromboxane A2.
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Ans. is 'a' i.e. W.B.C. casts RememberThey have specifically asked about pyelonephritis, not urinary tract infection. There are three basic forms of urinary tract infectionPyelonephritisCystitisAsymptomatic bacteriuriapyelonephritisUrinary tract infection involving the renal parenchyma, if there is no parenchymal invol...
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beriberi, may or may not be associated with hea failure and edema acute pernicious (fulminating) beriberi, in which hea failure and metabolic abnormalities predominate Wernicke encephalopathy is associated especially with alcohol and narcotic abuse ref harper 13th ed page 556
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(A) Streptobacillus moniliformis # Rat Bite Fever (RBF) is characterised by relapsing fever, rash and arthralgia occurring days or weeks after a rat bite.> Two different bacteria can cause this condition-Streptobacillus moniliformis and Spirillum minus, both of which are natural parasites of rodents.
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Ans. is 'a' i.e., Erythromycin Control of whooping cough o Control of whooping cough requires :? 1) Management of cases and contacts 2) Prevention by active immunization Cases: Erythromycin is the DOC. Alternatives are ampicillin, tetracyclin & septran. Contacts : Those who are exposed ---> 10 days erythromycin
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Ans. is 'a' i.e.. Generalised lymph adenopathy Revised WHO clinical staging of HI V,'A IDS for infants and childreno Clinical Stage 1AsymptomaticPersistent generalized Lymphadenopathyo Clinical Stage 2HepatosplenomegalyPapular pruritic eruptionsSeborrhoeic dermatitisExtensive human papilloma virus infectionExtensive mo...
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Ans. d. Ring fracture of foramen magnum with lumbar spine injury (Ref: Ready 33/e p247; Parikh's 6/4.94-4.97)"Ring fracture: This term is commonly used to signify any fracture around the foramen magnum. Technically it means a fissured fracture about 3.5 cm outside the foramen magnum at the back, involving middle ear si...
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Zygote first divide into blastomere, 16 cell stage is known as Morula.
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Prostatic urethra is the widest and most dilatable pa of the urethra and is concave anteriorly.
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The nymphal and adult mites do not feed on veebral host but instead exists as free living forms in the soil. It is the larva (chigger) which feed on the veebral hosts and pick up the rickettsiae. The scrub typhus is caused by R. tsutsugamushi and the true reservoir is trombiculid mite. Tetracycline is the drug of choic...
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Criteria for Diagnosis of Myeloma: Major criteria: Plasmacytomas on tissue biopsy Marrow plasmacytosis >30% plasma cells Monoclonal globulin spike on serum electrophoresis >3.5 gm/dL for immunoglobulin (Ig) G or >2.0 gm/dL for IgA; 1.0 gm/ 24 hrs of kappa or lambda light-chain excretion on urine electrophoresis in the ...
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Nasopharyngeal carcinoma Due to obstruction of eustachian tube , there is serous otitis media and leads to hearing loss. M/C site of origin - Fossa of Rosenmuller M/C type - Squamous cell carcinoma M/C Presentation - cervical lymphadenopathy (Neck Mass)
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Ans. C. Corrosive acid poisoningGastric Lavage is contraindicated when patients havea. Corrosive substance poisoningb. Convulsion (strychnine, tetanus)c. Comad. Volatile poisons (kerosene)e. Hypothermiaf. patients at risk of gastrointestinal hemorrhage or perforation.g. aluminum phosphide poisoning
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MSH causes loss of appetite and thus agonists to this agent can be used for the treatment of obesity
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Fulminant meningococcemia (purpura fulminans or Waterhouse – Friderichsen syndrome) is the most rapidly lethal form of septic shock experienced by humans.  It differs from most other form of septic shock by the prominence of hemorrhagic skin lesions (petechiae, purpura) and the consistent development of DIC.
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A i.e. Atropine
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Ans. is 'c' i.e. Projection o Projection is a narcissistic defense mechanism.Defence mechanismsNarissistic/PsychoticImmatureNeuroticMatureo Denialo Distortiono Projectiono Blockingo Introjectiono Passive - Aggressive behavioro Acting outo Hypochondriasiso Regressiono Schizoid fantasyo Somatizationo Controllingo Displac...
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Borderline ovarian tumours grade 0 tumors may demonstrate papillary tufting,stratification,epithelial atypia,exfoliation of cellular clusters,minimal mitotic activity No stromal invasion Patients have a high survival rate. runs a typical indolent course spontaneous regression of peritonial implants multiple sections ex...
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Ans: (c) SevofluraneRef: KDT 6th ed./373-374SEVOFLURANE* Sevoflurane is one of the inhalation (volatile liquid) anesthetic agents.* Induction and emergence of anesthesia is rapid with sevoflurane.* Absence of pungent smell makes it pleasant and administrate through face mask and is considered as anesthesia of choice in...
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Deoxyribonuclease I (DNAase I) Acts on single-stranded DNA, double-stranded DNA, and chromatin. Makes single stranded cuts in nearly any segment of DNA i.e. has low sequence specificity. Digest DNA that is not protected/not bound by protein, into its component deoxynucleotides. Used in DNA Foot Printing. E.g. (DNase I)...
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When sodium fluoride solution is applied on the tooth surface as a topical agent, it reacts with the hydroxyapatite crystals in enamel to form calcium fluoride, which is the main end product of the reaction.  As a thick layer of calcium fluoride gets formed, it interferes with the further diffusion of fluoride from the...
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Vivid hallucinations, Clouding of consciousness and Vivid hallucinations are the classic triad of symptoms of delirium tremens. The symptoms peak at 72-96 hours (3-4 days). Death occurs in 5% of the cases. Autonomic disturbance, ataxia, insomnia, poor attention span, insomnia and dehydration are also symptoms of DT. Co...
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Ans. is 'd' i.e., Plague o NVBDCP includes 6 vector home diseases of public health importance in India :i) Malariaii) Dengueiii) Filariaiv) Kala-azarv) Japenese encephalitisvi) Chikungunyafever
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Ans. A Lowers blood volume* Pressure diuresis lowers arterial pressure by lowering blood volume and, thereby, lowering cardiac output.* All of the other choices do lower arterial pressure, but are not caused by pressure diuresis.
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Fresh gas flow is important determinant of carbon dioxide elimination in breathing circuits.
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The inferior angle lies over the 7th rib or the 7th intercoastal space. Reference:page no:17 - vishram singh - upper limb & thorax, 2nd edition.
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Meissner corpuscles are dendrites encapsulated in connective tissue and respond to changes in texture and slow vibrations.Merkel cells are expanded dendritic endings, and they respond to sustained pressure and touch. The capsule is located relatively superficially, either in the basal epidermis (Merkel) or just below t...
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Some patients with hepatitis C may not respond well to treatment with interferon as expected. They are harboring genetic variation in IL28B usually. Ref: Harrison, Edition-18, Page-42
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Aspirin
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HNPCC / lynch is diagnosed bt modified emstredam eciteria.
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B i.e. Haematoidin
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Ans. is 'c' i.e., Guthrie Card
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Ans. is 'c' i.e., Complication of paial gastrectomy
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Ans. is d, i.e. All of the aboveRef: SK Chaudhary 7th/ed, p125-126,14Actions of the progesterone component of combined oral contraceptives:* Suppresses ovulation by its inhibitory action on the pituitary and the hypothalamus. This is predominantly achieved by estrogens but even by progesterone.* Causes atrophic changes...
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Ans. is 'b' i.e., Glycogen storage disease type II o Hepatosplenomegaly, characteristics E.C.G. findings and coarse facies are seen in Glycogen storage Type II or pompe's ds. o Death of infant before 2 yrs of age. o Pompe's disease is caused due to absent or reduced level of acid alpha glucosidase (acid maltase) activi...
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The picture shows Anti TNF Alpha monoclonal antibodies which are used in various conditions like rheumatoid ahritis(DMARD), ulcerative colitis, Crohn&;s disease etcRef: KD Tripathi 7th ed pg 883
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The intensity of uterine contractions describes the degree of uterine systole. During pregnancy uterus is quiescent, the tone is 2-3mmHg. During the first stage of labor it varies from 8-10 mmHg, it is inversely propoional to relaxation. D.C.DUTTA'S TEXTBOOK OF OBSTETRICS,pg no:117,7th edition
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i.e. (Borrellia Recurrentis): (509-KDT 6th)Indication of Mebendazole use are* Round worm-Ascaris - lumbricoides* Hook worm-Ancylostoma duodenale, Necator americanus* Whip worm-Trichuris trichura* Thread worm-Enterobius vermicularis* Trichinella spiralis-Less effective than albondazole* Hydatid disease-Less effective th...
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Ans. is 'd' i.e., Standard of living o Life expectancy at birth is a dimension of HDI (not life expectancy at one year).HUMAN DEVELOPMENT INDEX (HDDo HDI is a composite index combining indicators representing three dimensions.Components of HDIRecent (23"Ve & 22nAle of Park)Old (Previous editions)1. Longevity: - Life ex...
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The alveolar PO2 is found from the alveolar gas equation: PAO2 = PIO2 - PACO2/R We can assume that the inspired PO2 is the sea level normal value of 149 mm Hg. Therefore, neglecting the small correction factor, the alveolar PO2 is 149 - 20/1 or 129 mm Hg. Thus the alveolar-aerial PO2 diffusion is 129 - 90 = 39 mm Hg. T...
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Traumatic glaucoma causes:Inflammatory glaucoma due to iridocyclitis (anterior uveitis) (D-shaped pupili)HyphemaAngle recessionSubluxation of lensTrabecular edemaGhost cell glaucomaVasomotor reactionAdherent glaucoma
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Ans. d. (To make more of L-Dopa available to cross the blood brain barrier) (Ref. KDT 6th/418.)# Carbidopa & Benserazide are peripheral Decarboxylase inhibitor.# When administrated with L-dopa, they increase peripheral half-life of L-dopa & make more of it available to cross blood brain barrier.LEVODOPA# Levodopa is ra...
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The mucons membrane of the cystic duct forms a series of 5-12 crescentic folds, arranged spirally to form the so called spiral valve of Heister. This is not a true valve.
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Ans. Keratoconus
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Ans. is 'a' i.e., 1-2 days Incubation periods of imoortant GIT infectionsDiseaseCausative organismIncubation periodPoliomyelitisPoliovirus7-14 daysHepatitis AEnterovirus 72 (Picomavirus)15-45 daysHepatitis BHepadnavirus45-180 daysHepatitis CHepacivirus30-120 daysHepatitis DDeltavims30-90 daysHepatitis ECalcivirus21-45 ...
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For easy to remember : Sensitivity → "I know my patient has the disease. What is the chance that the test will show that my patient has it". Specificity → "I know my patient doesn't have the disease. What is the chance that the test will show that my patient doesn't have it".
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Paget's disease of the nipple is superficial manifestation of an intraductal breast carcinoma. The malignancy spreads within the duct up to the skin of the nipple and down into the substance of the breast. It mimics eczema of nipple and areola. In Paget's disease, there is a hard nodule just underneath the areola, whic...
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Norplant is implanted under the skin in the upper arm of a woman, by creating a small incision and inseing the capsules in a fanlike shape. Once inseed, the contraceptive works within 24 hours and lasts up to five years. Norplant should not be used in women with liver disease, breast cancer or blood clots. It releases ...
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Young maternal age is not risk factor for placenta pre , whereas advanced maternal age is a risk factor. Risk factor for placenta Pre: Prior history of placenta pre Multifetal gestation: Due to larger placental area Maternal age: Increasing frequency with increasing maternal age Multiparity: Increasing frequency with i...
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Infant is suffering from pneumococcal pneumonia (Gram positive α-hemolytic cocci). Pneumococci is differentiated from other α hemolytic Gram positive cocci by its susceptibility to optochin and bile solubility.
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Ans. is 'b' i.e., Brochioalveolar carcinoma Bronchioloalveolar carcinoma o It is a histological type of adenocarcinoma. o It occurs in the pulmonary parenchyma in the terminal bronchioloalveolar pattern. o The tumor is almost always in the peripheral poion of the lung. o More often it occurs as multiple diffuse nodules...
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In systemic capillaries pO2<CO2The decrease in O2 affinity of hemoglobin when the pH of blood falls is called the Bohr effect and is closely related to the fact that deoxygenated hemoglobin which occure in systemic capillaries. The pH of blood falls as its CO2 content increases, so that when the PCO2 rises, the curve s...
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Serum ACE was studied to determine the effect of chronic lung disease upon the blood level of an enzyme believed to originate from the lungs. The assay was performed in approximately 200 control subjects and 200 patients with chronic lung disease using hippuryl-L-histidyl-L-leucine as substrate. Enzyme activity greater...
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Key Concept:  Hyoglossus muscle inserts into lateral part of tongue.
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Ceain lysyl residues are modified by lysyl oxidase, a copper-containing protein that conves e-amino groups to aldehydes. The aldehydes can either undergo an aldol condensation to form a C = C double bond or to form a Schiff base (eneimine) with the e-amino group of an unmodified lysyl residue, which is subsequently red...
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(C) (Kidney) (681 - Ganong 23rd)Vitamin Do Vitamin D is the major vitamin involved in the absorption of calciumo Beside dietary intake, cutaneous synthesis is the other and more important source of vitamin D (cholecalciferol) in the body. The keratinocytes of stratum corneum of the epidermis of skinQ contain 7- dehydro...
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Ans: B (Osteopetrosis) Ref: Harrison s Principles of Internal Medicine, 18th ed & Nelson Textbook of PediatricsExplanation:OsteopeniaIt is a condition where bone mineral density is lower than normal.It is considered to be a precursor to osteoporosis.However, not every person diagnosed with osteopenia will develop osteo...
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Mid palmar space Infection from thumb and index finger --- thenar space Middle and ring finger--mid palmar space Little finger-- fore arm space of Parona
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Ans. is 'c' i.e., Number of daughters a newborn girl will have during life time Net reproduction rate Net reproductive rate is defined as "The no. of daughters a new born girl will bear during her lifetime assuming fixed age specific feility and moality rates" It is the only feility related statistics which also takes ...
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1-3mm/day REF: Ganong's 22' ed p. 427, Guyton 11th edition page 999 Speed of sperm is 3mm/day (Ganong) The normal motile, feile sperm are capable of flagellated movement though the fluid medium at velocities of 1 to 4 mm/min. (Guyton)
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The indications for operation are bouts of renal pain, increasing hydronephrosis, evidence of parenchymal damage and infection. Nephrectomy should be considered only when the kidney has largely lost most of its function (<10% split function). Mild cases should be followed by serial ultrasound scans and operated upon if...
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Answer- D. 17ERBB2, a known proto-oncogene, located at the long arm of human chromosome 17 (17q12)HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) which is plasma membrane-bound receptor tyrosine kinase.
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SCFE Males are more commonly affected Commonly occurs during adolescence- presents with pain, antalgic limp, with the affected side held in a position of increased external rotation A classical sign is tendency of thigh to rotate in to progressively more external rotation, as the affected hip is flexed called as Axis d...
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Ans. is 'b' i.e., Prussian blueo Fontana-Masson method : most commonly used. It relies upon the melanin granules to reduce ammoniacal silver nitrate.o Ped's iron stain/Prussian blue method : It is the classic method for demonstrating iron in tissues. The section is treated with dilute hydrochloric acid to release ferri...
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B i.e. Tetracaine
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Ans. is 'c' i.e., Nephrotoxicity
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Luteinising Hormone LH is a water-soluble glycoprotein of high molecular weight secreted by beta cells of the anterior pituitary gland LH surge initiated by estrogen lasts for 48 h. LH level doubles up in 2 hrs and peak plateaus for 14 hours before declining. Minimum of 75 ng/ml is required for ovulation Ref: Shaw's Te...
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Ans. A. Waldenstrom macroglobulinemiaExplanationMYD88L 265P is expressed in 90 to 95% of WM cases when more sensitive allele-specific PCR has been employed.Waldenstrom's macroglobulinemia (WM):It is a IgM-secreting lymphoplasmacytic lymphoma (LPL).Clinical manifestations:Cytopenia resulting from bone marrow infiltratio...
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Ans. Micropsia
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Ans. is 'b' i.e., Local recurrence is common after excision
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The natural cycles of JE vrirus are:- a. Pig → Mosquito → Pig b. Ardeid bird → Mosquito → Ardeid bird Japanese encephalitis Caused by a group B arbovirus (flavivirus)  It is a Zoonotic disease i.e., infecting mainly animals and incidentally man. In the south, epidemics have occurred in Karnataka, Andhra Pradesh. Tamil ...
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Answer is D (Bronchopulmonary Aspergillosis) Bronehoptilmoi.ary Aspergillosis has not been mentioned as a cause for pneumothorax. Aificial ventilation is an established cause for iatrogenic pneumothorax while Marfan's syndrome and Eosinophilic granuloma are established causes for secondary spontaneous pneumothorax.
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FREE RADICAL SCAVENGING SYSTEM Antioxidants fall into two classes: Preventive antioxidants, which reduced the rate of chain initiation. They are Glutathione Peroxidase, Catalase. Chain-breaking antioxidants, which interfere with chain propagation. They are Superoxide Dismutase, Uric Acid, Vitamin E. Reference...
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Fracture Thoracic spine is most commonly seen spinal injury . It is usually due to hyperflexion injuries due to rapid deceleration when the aircraft strikes the ground. Most of the aircraft accidents occur on landing (35 %) or take off (35 %)
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Ans. is 'd' i.e., Phenobarbitone Theophylline poisoning Theophylline has a narrow margine of safety. Dose dependent toxicity stas from the upper pa of therapeutic concentration range. Adverse effects are primarily referable to the GIT, CNS and CVS. Children are more liable to develop CNS toxicity. Treatment Prophylacti...
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Ans. (d) MRI(Ref Schwart 10th edition Page 527)* Mammography - IOC for women >35 years* Mammography - IOC for Screening purpose* MRI- IOC for screening in High risk Women* Mammography - IOC for detecting Ductal carcinoma In-situ lesions* Mammography - IOC to detect Micro calcifications (Which is the only feature for DC...
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Thornwaldt's disease or Pharyngeal bursitis is an infection of pharyngeal bursa located in the midline of the posterior wall of the nasopharynx. Ref: Textbook of ENT, Dhingra; 6th edition; Pg no: 245 ref img
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Suicide is the most common cause of premature death. Around 20-50% of patients with schizophrenia attempt suicide and around 5-10% of patients with schizophrenia commit suicide. If you have to chose a single figure, the best answer would be 10% of patients with schizophrenia commit suicide. The most impoant factor for ...
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Although the DCT is the shoest segment of the nephron, spanning only about 5 mm in length in humans (1), it plays a critical role in a variety of homeostatic processes, including sodium chloride reabsorption, potassium secretion, and calcium and magnesium handling Ref: guyton and hall textbook of medical physiology 12 ...
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There is no cailage between tragus and crus of the helix and an incision made in this area will not cut through the cailage and is used for the endaural approach in surgery of external auditory canal and mastoid. Reference: Dhingra 6th edition; page no 2
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A bicyclist directly lands on his perineum leading to spongy urethrs / Bulbar urethral injury.
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Pancreas divisum occurs when the embryologic ventral and dorsal pancreatic anlagen fail to fuse, so pancreatic drainage is mainly through the accessory papilla. It is the most common congenital anatomic variant of the human pancreas. Reference: Harrisons Principles of Internal Medicine, 18th Edition
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Chronic poisoning called 'Iodism' can occur due to prolonged use of iodine salts. The common clinical features of iodism are metallic taste, anorexia, parotid swellings sometimes referred to as iodide mumps, lymphadenopathy, rhinorrhoea, stomatitis, and conjunctivitis.RK Sharma concise textbook of forensic medicine 3e ...
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Ans. is 'a' i.e., No cause of death is found on gross as well as histopathological examination Types of autopsy1) Normal autopsy - cause is apparent from gross examination2) Defective autopsy - cause was ascertainable, but was not ascertained due to constrains on the part of doctor, hospital, facilities etc3) Obscure a...
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Ans. is 'a' i.e., Radiation
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Posterior communicating aery is a branch of the cerebral pa of the internal carotid aery. The cerebral pa lies at the base of the brain.
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Ans. C. Gouta. Acute gout causing swelling, erythema and extreme pain and tenderness of the first metatarsophalangeal joint.b. This is also known as Podagra- Colchicine and indomethacin are the drug of choice in this acute attack.
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A i.e. Autosomal dominant disorder Autosomal dominant disease cannot occur in offspring of an unaffected individuals. Because the allele is dominant it will always express phenotypically (clinically) and hence both parents can't be normal in autosomal dominant disorders even if they have a single abnormal gene.
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