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In order of frequency, the anterior descending coronary aery is the most commonly involved with atherosclerosis, followed by the right coronary, the circumflex, and the left main coronary aery.
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Reference :Robbins basic pathology 9th edition pg no 117:As a result of the polymorphism at the major HLA loci in the population, a viually in nite number of combina- tions of molecules exist, and each person expresses a unique MHC antigenic pro le on his or her cells. The com- bination of HLA alleles for each person i...
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Ans. B: Oligohydramnios Maternal complications of multiple pregnancy: Anemia Pre-eclampsia (25%) Polyhydramnios (10%) Malpresentations Preterm labour (50%) Early rupture of membranes Prolonged labour Postpaum hemorrhage due to uterine atony Sub-involution of uterus Antepaum hemorrhage
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CAM PTOTHECIN ANALOGUES Topotecan and Irinotecan are two recently introduced semisynthetic analogues of camptothecin, an anti tumour principle obtained from a Chinese tree. They act in a manner similar to etoposide, but interact with a different enzyme (DNA topoisomerase I). Their binding to this nuclear enzyme allows ...
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(D) Anterior wall Ml > There was ST elevation from v1 to v6 and to the simplest that you could not find any right axis deviation to at least rule out RBBB> So the answer is Anterior wall Ml
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Conversion of glucose to glucose-6-phosphate is a method by which glucose is trapped inside the cell. Later it is diverted to many different pathways depending upon energy state of the cell.
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Components of complement cascade mediate various biological responses  C5a, C3a, to a lesser extent C4a → are called anaphylotoxin because they have effects similar to those of mast cell mediators that are involved in the reaction called anaphylaxis. These effects are due to stimulation of histamine release by this an...
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Lichen planus lesions are classically violaceous well defined polygonal itchy papules.
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Ans. is 'b' i.e., -118
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Ans. b (Loop of Henle & collecting duct). (Ref. Ganong, Physiology, 21st/pg.721)NEPHRONS# Proximal convoluted tubule-- reabsorbs all of the glucose, inorganic phosphate, Cl, lactate and amino acids and most of the bicarbonate, sodium, and water. Secretes ammonia, which acts as a buffer for secreted W+.QThin descending ...
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Propofol produces coical EEG changes. Propofol appears to possess profound anticonvulsant propeies. CBF ICP CMRO2 Seizure Thiopentone ||| ||| ||| ||| Ketamine || || | | Halothane || || | | Nitrous oxide | | | | Previously thiopentone was used nowerdays propofol is used.
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Ans. is 'd' i.e., Diffuse alveolar damage There is focal necrosis (not diffuse) of alveolar walls.
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ACE inhibitors like lisinopril, perindopril, ramipril and ARBs like losaan, telmisaan could decrease the incidence of diabetic nephropathy by decreasing protein levels in the urine especially albumin They r DOC for diabetes with HTN. Ref: KD Tripathi 8th ed.
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DB developmental groove is not found on mandibular second molars.
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(IV Lignocaine): Ref: 463-KDT (514-KDT 6th)Treatment of digitalis induced ventricular arrhythmias* Lignocaine IV repeated as required is the drug of choice. It suppresses the excessive automaticity but does not accentuate A V block* Phenytoin is also useful but not preffered now (sudden death occurs)* Quinidine and pro...
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(B) Hypodense shadow in CT scan Hematoma typeEPIDURALSUBDURALLocation* Between the skull and the duraBetween the dura & the arachnoidInvolved vessel* Temperoparietal locus (most likely) - Middle meningeal artery* Frontal locus - anterior ethmoidal artery* Occipital locus - transverse or sigmoid sinuses* Vertex locus - ...
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.the first step in the diagnosis of an epidemic is the verification of the diagnosis.it may sometimes happen that the rep may be spurious,and arise from misinterpretation of signs and symptoms by the lay public.it is therfore necessary to have the verification of diagnosis on the spot as quickly as possible.it is not n...
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Answer is A (Normal saline with forced diuresis with Thiazides): Thiazide diuretics should not be used in cases of hypercalcemia as these may themselves cause hypercalcemia.
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(d) Gout- The hallmark physical finding is focal bone pain (tenderness) with palpation and stress. Also bilateral goes in favor of stress fracture.
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Ceain dietary substances interfere with thyroid hormone synthesis at some level, these are termed 'goitrogenic'. Vegetables belonging to the Brassicaceae (Cruciferae) family (e.g., cabbage, cauliflower, Brussels sprouts, turnips, and cassava), has been documented to be goitrogenic. Native populations subsisting on cass...
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Ans. is 'd' i.e., Brucellosis Water Borne diseases o Those caused by the presence of an infective agent a)Viral Hep. A, Hep E, Polio, Rota virus diarrhoea b)Bacteria Typhoid & paratyphoid. Cholera, Bacillary dysentry. E coli diarrhoea c)Prnto:oal A moebiasis, Gardiasis. d)Helminthic round worm. thread worm, hydatid dis...
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Ans. is 'a' i.e., Hypersensitivity to adult worm of Loa-Loa [Ref: Chatterjee 12thIe p. 202}Loiasis* Loiasis is caused by L. Loa (the African eye worm)* Habitat of adult worms is subcutaneous connective tissue of man; often in the sub-conjuctival tissue of the eye.* The worm passes its life cycle in two hosts :# Man# Ch...
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Ans. is 'd' i.e., Acute congestive glaucoma {Ref: Clinical ophthalmology 5th/e p. 139]Floaterso A floater is something in the fluids of the eye that casts a shadow on the retina and looks like a dark spot or spots floating around in the field of vision. Floaters are usually described by patients, as small, semitransluc...
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Ans. C: Vancomycin The beta-lactam ring is pa of the structure of several antibiotic families, the principal ones being the penicillins, cephalosporins, carbapenems, and monobactams, which are, therefore, also called beta-lactam antibiotics. These antibiotics work by inhibiting bacterial cell wall synthesis. This has a...
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Ans. is 'b' i.e., Malignant hypeension There is concentric hyperplastic proliferation of the smooth muscles together with fine concentric layering of collagen to form a hyperplastic aeriolitis (Onion skin lesion). Malignant nephrosclerosis is the form of renal disease associated with malignant or accelerated phase of h...
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Papillary thyroid cancer most typically manifests either as a palpable thyroid nodule or as an incidental imaging finding . Occasionally, a metastatic PTC manifests as a painless lateral neck mass that is clinically detected before detecting the primary thyroid lesion. PTC disseminates lymphatic spread, PTC is characte...
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Ans. is 'b' i.e., Graft vs host disease
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Answer-C. Posterior subcapsularComplicated cataract refers to the lens opacification secondary to some other intraocular disease, Anterior uveitis is the most common cause.Posterior coical complicated cataract : - This type of cataract is due to affections of posterior segment. This cataract is located in a posterior s...
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Answer- A. Memory cellsAfter hlperacute rejection, transplantation of a second gfaft, which shares a significant number of antigenic determinants with the first one, results in a rapid (2 - 5 days) rejection. It is due to presence of T-lymphocyte sensitized during the first graft rejection(memory cells).
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Gastric atrophy has no association with hemochromatosis.
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Ans. (c) OrbitRef: Khurana Anatomy 2/e, p. 493It is a fascial expansion of the extraocular muscles formed by fusion of sheaths of MR, IR, LR, IO extending from the posterior lacrimal crest to the lateral orbital margin.
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Ans. Endocapsular
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Ans. is `b' i.e., Sigmoid Volvulus Volvulus does not cause bleeding Causes of lower G.I. bleeding A) Common B) Less common C) Rare Angiodysplasia Neoplasia ---> Carcinoma, polyps Meckel's diveiculum Diveiculitis Colitis --> Radiation, Ischaemic, Ulcerative Intussusception Anorectal disease Infective --> Enteric fever, ...
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Ans. is All
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Nitrates are primary venodilators. Nefidipine is a calcium channel blocker and aeriolar dilator.Fenoldopam , minoxidil also cause vasodilationRef: KD Tripathi; 6th ed, pg 540
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Phase 1 Clinical trials is used to evaluate Maximum tolerated dose (MTD) of a new drug
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It acts on the postsynaptic membrane of peripheral nerves to block acetylcholine receptors Botulinum toxin is the most potent bacterial toxin known. One microgram of purified toxin is able to kill 200,000 mice. The toxin is released only upon the death and autolysis of the organism, and is thus classified as an exotoxi...
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- the term ergonomics is derived from ergon, meaning work and nomos , meaning law. - it simply means fitting the job to the worker. - the objective of ergonomics is to achieve the best mutual adjustment of man and his work for the improvement of human efficiency and well-being. Reference : Park's textbook of preventive...
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Folic acid deficiency causes megaloblastic anemia. Human breast milk, pasteurized Cow's milk, and infant formulas provide adequate amount of folic acid. Goat's milk is deficient in folic acid.
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DIAGNOSIS OF CBD STONE USG : first test, can document GB stones and estimate the CBD diameter A dilated bile duct (>8mm in diameter) in a patient with gallstones, jaundice and biliary pain is highly suggestive of choledocholithiasis MRCP : Provides excellent anatomic detail, with sensitivity and specificity of 95 %and ...
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(Personality) (16-Neeraj Ahuja 6th)Commonly used projective tests of personality are* Rorschach inkblot test* TAT (Thematic apperception test)* D APT {Draw a person test)* Sentence completion test.
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(Lead poisoning): Ref: 433-R (284- Basic pathology 8th)LEAD: Inhalation is the most important route of occupational exposure* Lead interferes with heme biosynthesis, it causes microcytic hypochromic anemia, punctate basophilic stippling of erythrocytes is characteristic.Toxic and carcinogenic metalsMetalDiseaseOccupati...
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Decreased visual acuity may occur as a result of macular involvement or severe vitreous inflammation. ... An active toxoplasmic retinochoroiditis is whitish and moderately exudative with ill-defined borders and involves the macula in a majority of patients.
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Ans. is 'c' i.e., 200000 iu
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Locally there will be regional lymphadenopathy where the lymph nodes may be matted. In late stages, a cold abscess-Painless, fluctuant mass, not warm; significantly, there are no signs of inflammation.This is a clinical manifestation of underlying caseation. Left untreated, the cold abscess initially deep to the deep f...
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In a normal individual, shining a light in either eye will result in both pupils constricting due to contraction of the pupillary sphincter muscles. In contrast, the pupillary dilator muscle dilates the pupil. The ciliary muscle is involved in focusing the eye (accommodation).
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Ans. is 'a' i.e., Dead born Signs of dead born (intrauterine death : IUD) are (i) Rigor mois at bih, (ii) Maceration, (iii)Putrefaction, and (iv) Mummification.
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Sch is a depolarizing blocker.
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Surgical treatment of vasomotor rhinitis - Vidian neurectomy which is sectioning of parasympathetic secretomotor fibres of nose
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Ulnar claw hand is seen in lower ulnar nerve palsy not Iin high ulnar nerve palsy It is called as ulnar paradox Ulnar paradox # Not severe claw hand deformity, but inability to flex DIP and weakness of flexing MCP & PIP of digits IV and V # Seen with higher nerve injuries (cubital tunnel syndrome) # More severe muscle ...
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The most frequent single cause of death in breech presentation is intracranial hemorrhage due to tentorial tears, these tears are the result of sudden excessive pressure on the after coming head and may be aptly described as the snapping of the internal greyropes of the cranium
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Ans. is 'd' i.e., Caudate nuclei Important facts about cerebellumo Cerebellum is divided into -i) Cerebellar Cortex (external):- Contains five cellspurkinje cells, granule cells, basket cells, stellate cells and golgi cells.ii) Deep cerebellar nuclei (external):- There are four nuclei dentate fastigial, globose, and em...
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Irreversible retinal pigmentation is associated with the use of thioridazine at dosages above 1000mg/day(hence <800/day ) nocturnal confusion is an early sign of this adverse effect. Reference: P.3121 chap. 31.17First-Generation Antipsychotics (Kaplan & Sadock's Comprehensive Textbook of Psychiatry, 9th Edition)
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Actually all the investigations, provided in the options, can be used in POAG. "A good baseline evaluation and a record of all parameters - IOP (Tonometry), perimetly, optic nerve head evaluation and gonioscopy - over the years should be available for proper management".  -- Parson's "Careful examination of disc chang...
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In spinal anesthesia LA is injected into subarachnoid space (space between pia matter and arachnoid matter).
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(B) Obsessive-compulsive disorder # OBSESSIVE-COMPULSIVE DISORDER:> Washers:* This is commonest type. Here the obsession is of contamination with dirt, germs, body excretions and the like.* The compulsion is washing of hands or the whole body, repeatedly many times a day.* It usually spreads on to washing of clothes, w...
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Residual chlorine is detected by, Oho-toluidine test is used to determine both free and residual chlorine with speed and accuracy. It is done using oho-toluidine dissolved in 10 per cent solution of hydrochloric acid. When added to water containing chlorine it turns yellow and its intensity varies with the concentratio...
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Superior Oblique muscle: Origin : from body of sphenoid (superomedial to optic canal - opening in lesser wing of sphenoid ) Inseion - Sclera of the eyeball posterior to equator of eyeball Trochlea gives trochlear nerve supplying S.O.M Actions of S.O.M: depression, abduction & intorsion
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Reduce the production of DHT Finasteride is a 1-a-reductase inhibitor. It acts by blocking the conversion of testosterone of DHT. It can be used to relieve the static component of BHP (though its beneficial effect is delayed). Due to decrease in DHT, it can cause impotence. It can also be used in he treatment of male p...
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(A) Fine touch, vibration
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Fracture of hyoid bone with inward driving of its distal fragments are seen in 30-50% cases of throttling. Throttling refers to the asphyxia produced by compression of the neck by human hands. In this, death occurs mainly due to occlusion of carotid aeries.
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Ans. a (Concomitant). (Ref. Parson, Diseases of Eye, 18th/341, Basak, Ophthalmology, 2nd /298)SQUINTS. No.Concomitant (Aparalytic)Paralytic (Nonconcomitant)1.Sudden onsetInsidious onset2.Developmental originAcquired3.Infants and childrenAdults affected4.DiplopiaNo diplopia5.Normal head postureAbnormal head posture6.No ...
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Answer is A (IgM against core antigen): IgM antibody against core antigen is a diagnostic of an acute infection with hepatitis B virus. IgM antibodies against core antigen are characteristically absent in patients with chronic: hepatitis B. (Absent in both forms of chronic hepatitis, namely, chronic active hepatitis an...
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Ans. (b) Specific protectionRef: K. Park 23rd ed. / 41* IFA supplement is a chemoprophylaxis given during pregnancy for anemia. It comes under primary level of prevention which is implemented under specific protection.
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*Patient in question has infected non-union with shoening of 4cms. Ilizanov fixature with distraction osteogenesis will be the best option. Ref: Maheshwari 9th/e p.158
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(C) Suxamethonium # Suxamethonium chloride (Succinylcholine, Sscoline, or colloquially as Suxa) is a medication widely used in emerger cy medicine and anesthesia to induce muscle relaxation, usually to make endotracheal intubation possible> Side effects:> Side effects include muscle pains, acute rhabdomyolysis with hyp...
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Ans: A (Methionine) Ref: Park 22nd edition pg 564Explanation:Cereals lack lysine and pulses lack methionine.These are called the limiting amino acid. A food containing both pulses and cereals would be complete food, as the deficiency of lysine in cereals is supplemented by the lysine in pulses.Also methionine is compen...
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Abdominal aortic aneurysms, which are defined as an increase in aortic diameter of 50% or more, are the most frequent aneurysms, usually developing after the age of 50 years. The most common cause of these abdominal aortic aneurysms is atherosclerosis. Aneurysms secondary to atherosclerosis are less common in the other...
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Ans. is 'd' i.e., Nodular sclerosiso Mediastnal lymphnode involvement is mostly seen with Nodular sclerosis type of HL.
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Angiography: "string of beads"/"Pile of plates" appearance of FMD is classically seen on angiography. Fibromuscular dysplasia most commonly causes small stenoses along a vessel with intervening areas of dilatation (small aneurysms), creating a "string of beads" appearance. Less commonly the stenosis has a smooth tapere...
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Pseudomonas aeruginosa REF: Mayo Clinic Internal Medicine Board Review 9th edition Page 845, Infectious diseases of the respiratory tract by Michael E. Ellis Page 511 "Pseudomonas aeruginosa is a ubiquitous organism commonly isolated from patients with cystic fibrosis and bronchiectasis"
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Answer is B (Amyotrophic lateral sclerosis) : The presence of both lower motor neuron features (progressive atrophy and weakness of hands and firearms) and upper motor neuron features (spasticity and hyper reliever, in the patient leads us to the diagnosis of .-bnyotrophic lateral sclerosis. Increased signal in the coi...
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Ans. is 'a' i.e., Index finger Felono Infection of the terminal pulp space is known as 'Felon', which is common and potentially serious,o Dull pain and swelling are the first symptoms, and if untreated by the third day there are severe nocturnal exacerbations of throbbing pain, interfering with sleep, o Light pressure ...
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Ans. (A) It is a 4th generation cephalosporin.(Ref: Goodman Gilman 12th/e p1498, KDT 8/e p779)Cefepime is 4th generation cephalosporin with good activity against PseudomonasIt is given 8-12 hourly
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The amount of gas transmitted into the peritoneal cavity should depend on the measured intraperitoneal pressure, not the volume of gas inflated. Intraperitoneal volume capacity varies significantly between individuals. Most prefer to insufflate to 25 to 30 mm Hg for positioning the cannulas. This means that enough CO2 ...
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Answer is A (Haemolytic jaundice) All findings in the question corroborate with a haemolytic picture. Presence of Urobilinogen in urine rules out an obstructive cause for jaundice. Decrease in haemoglobin and elevated bilirubin levels are consistent with a haemolytic cause. Gall stones can be explained by precipitation...
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Ans. a. MRI (Ref: Apley's 11/848, 849)History of fall followed by tenderness in Scarpa's triangle and leg in externally rotated position is suggestive of fracture neck of femur. An impacted, undisplaced fracture is likely to be missed on an X-ray. An MRl or a bone scan would be needed to diagnose the lesion."Impacted f...
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Ans. is 'c' i.e., Dabigatrano Ximelagatran was the first oral direct thrombin inhibitor approved; howrever, it was subsequently withdrawn from the market because of reports of fiver failure.o Recently a new oral direct inhibitor, dabigatran, was approved for use in Europe for prevention of various thromboembolism in pa...
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In adult life, the first arch aery is represented by the maxillary aery .the second arch aery persists for some pa of fetal life as the stapedial aery:it may contribute to the formation of the external carotid aery. Ref: Human Embryology, Inderbir Singh, 10th edition, page no: 251
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Ans. is 'a' i.e., Keratin o Dermatophytes are keratinophilic fungi, living only on the superficial dead keratin. That is why they infect skin, hair, and nail. In skin, they infect most superficial layer of the epidermis i.e. stratum corneum. They do not penetrate living tissues. Dermatophytes cause a variety of clinica...
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Acanthamoeba keratitis Mode of infection. Corneal infection with acanthamoeba results from direct corneal contact with any material or water contaminated with the organism. Following situations of contamination have been described: Contact lens wearers using home-made saline Non contact lens related situations include ...
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Ans. is 'b' i.e., Case-control study
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Breast development, termed thelarche, begins in most girls between the ages of 8 and 13 years. Thelarche prior to age 8 or lack of breast development by age 13 is considered abnormal and should be investigated. Ref: Hoffman B.L., Schorge J.O., Schaffer J.I., Halvorson L.M., Bradshaw K.D., Cunningham F.G., Calver L.E. (...
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Harrison's textbook of internal medicine 17th edition. *Imaging studies (MRI,CT scan) may show hydrocephalus and abnormal enhancement of basal cisterns or ependyma . *CT and MRI reveals contrast enhanced ring lesions ,but biopsy necessary to establish the diagnosis .
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Ans. is 'd' i.e., All the above Electrolyte abnormalities seen in brain injury* Electrolyte abnormalities occur in 60% of the patients with head injury.* Hyponatremia is the most common electrolyte abnormality seen and is often secondary to SIADH.* Other Electrolyte disorders including hypernatremia, hypokalemia, hyper...
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Ans BBasal cisternal enhancement is often seen in TB meningitis and CT scan has lower resolution for skull base as compared to MRI. PET and SPECT have more role in neoplasms and degenerative disorders of brain.
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Pseudocholinesterase which metabolizes succinylcholine is synthesized by liver and is present in plasma. True cholinesterase which metabolizes acetylcholine is synthesized by muscle end plate. Ref: KD Tripathi 8th ed.
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"High-dose penicillin G and clindamycin, along with third-generation cephalosporins, should be given intravenously until the patient's toxicity abates. The mainstay of management is early surgical excision of the necrotic tissue " Bailey and love 26th edition Pg 430
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Ans. is 'a' i.e.. Less than 15 years Dependency ratiooThe proportion of persons above 65 years of age and children below 15 years of age are considered to be dependent on the economically productive age group {15-64 years).o The ratio of combined age group 0-14 years plus 65 years and above to the 15-65 years age group...
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Prophylactic antibiotics for the cesarean section have been conclusively proven to be beneficial.The first dose is administered at clamping and at least 2 more doses given 8th hourly intravenously in elective cases. Single-dose prophylaxis has been recommended by the ACOG. Both ampicillin and first-generation cephalosp...
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Control of Setting Time: Manufacturing process Sintering temperature: Higher the temperature, the more slowly the cement sets. Particle size: Finer particles react more quickly as a greater surface area is exposed to the liquid. Water content of liquid: Presence of excess water accelerates, whereas insufficient water ...
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Most common trisomy in humans is trisomy 16,most common type of autosomal trisomy that survive upto birth in trisomy 21.
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Leukotriene modifers ( monteleukast,zafirulukast) may be considrrco as alternatives to low dose inhaled coicosteroids in patients with mild persistent asthma . Has no role in treating acute severe asthma Ref Harrison 19th edition pg 1673
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Fuch's heterochromic iridocylitis is a chronic non-granulomatous uveitis. Sarcoidosis, TB and brucellosis cause granulomatous uveitis. Ref: Parson's 22nd/e p. 251 & 21st/e p. 251 &21st/e p.229.
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(Ref: KDT 6/e p279) Coicosteroids induce the synthesis of lipocoins that inhibit the enzyme phospholipase A2.
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CDC Stage 3 (AIDS)-Defining Oppounistic Illnesses in HIV Infection:Bacterial infections, multiple or recurrentCandidiasis of bronchi, trachea, or lungsCandidiasis of esophagusCervical cancer, invasiveCoccidioidomycosis, disseminated or extrapulmonaryCryptococcosis, extrapulmonaryCryptosporidiosis, chronic intestinal (>...
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.lead time is the advantage gained by screening.that is the period between diagnosis by early detection and diagnosis by other means.the benefits are alwaysd evaluated in terms of outcomes. ref:park&;s textbook ,22 nd edition,pg no 128
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Parathyroid adenoma: Tc99m Sestamibi scan used (previously thallium subtraction study is done) Pancreatic carcinoma:Selenium-methionine scan used Bone metastasis:Tc99m- MDP scan used Meckel's diveiculum:Tc99m- Peechnate scan used Normal Bone Scan Tracer uptake greatest in axial skeleton Background activity of soft tiss...
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Mycosis fungoides is a cutaneous T cell lymphoma Etio: - Unknown, sometime HTLV I virus- It is MC cutaneous lymphoma Histological findings : 1. Sezary cells - Sezary cell are malignant lymphocytes with increased cell size and convoluted nucleus aka Cerebriform nucleus 2. Epidermo tropism - affection to move towards the...
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Foreign body is likely to go in the right lung rather than left because of following characteristics of right bronchus :- Shoer in length Wider lumen More veical Right inferior lobar bronchus is in continuation with the principal bronchus Option 4 - Right bronchus is shoer , more veical and wider than the left (not the...
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