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Hemophilia B- inherited, X-linked recessive disorder resulting in deficiency of functional plasma coagulation factor IX. Morbidity and death are primarily the result of hemorrhage, although infectious diseases (e.g., HIV, hepatitis) also has some role.
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Internal biliary fistula Cholecystoduodenal fistula(72-80%) are MC biliary enteric fistulas followed by cholecysticolic fistula (8-12%). Etiology Calculous biliary tract disease (90%). Duodenal ulcer(6%) Neoplasm, trauma, Parasitic infestation and congenital anomalies (4%) Ref : Sabiston 20th edition Pgno :1507
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Ans. is 'b' i.e., Mid year population Crude death rate It is the simplest measure of moality. It is defined as "the number of death (from all causes) per 1000 estimated mid-year population in one year, in a given place".
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(A) Borrelia burgdorferi > Lyme disease, or borreliosis, is an emerging infectious disease caused by spirochete bacteria from the genus Borrelia. It is caused by Borrelia burgdorferi transmitted by the bite of Ixodid ticks.> The natural reservoir hosts are rodents, deer and other mammals. Ixodes dammini and related spe...
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The patient is suffering from suppurative (bacterial) cholangitis, which can occur as a complication of infestation by the roundworm, Ascaris lumbricoides and by the liver flukes, Clonorchis sinensis and Fasciola hepatica. Biliary tract obstruction produces jaundice and extreme itching, with dark urine and pale feces. ...
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Ans. C. Meniscus injury. (Ref. Orthopedics by Ebnezar 4th/Pg. 257).A positive McMurray fs test is diagnostic of a meniscal injury.McMurray test# The McMurray test, also known as the McMurray circumduction test is used to evaluate individuals for tears in the meniscus of the knee. It is a rotation test for demonstrating...
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Boiling point of methoxyflurane is 104.7°C whereas other fluorinated inhalational anesthetics have boiling point between 50°C to 60°c (except desflurane: 22.9°C)
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ANSWER: (B) Dermatitis herpetiformisREF: Journal of Investigative Dermatology Symposium Proceedings (2004) 9, 47-51 (http:/./ www.nature.com/jidsp/journal/v9/nl/full/5640132a.html) Therapy of Skin Diseases, By Yoshiki Miyachi, page 433The responsiveness of DH to dapsone:Responsiveness to dapsone was once considered a d...
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Uterovaginal canal (mesoderm) comes in contact with the urogenital sinus (endoderm). Sinovaginal bulbs are formed by the proliferation of endodermal lining. Solid vaginal plate is derived paly from mesoderm of uterovaginal canal and paly from endoderm of sinovaginal bulbs. Vagina is formed by canalization of vaginal pl...
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Ans. C. Methylphenidate. (Ref. Kaplan and Sadock's Concise Textbook of Clinical Psychiatry 3rd edition: pg. 492; http:// ps.psychiatryonline.org/ article.aspx? articleid- 83195) ATTENTION DEFICIT/HYPERACTIVITY DISORDER (ADHD)General comments# Male to female ratio--10:1# Overtreatment is common; differentiate from child...
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(A) Cell body # Nissl body (or Nissl granule or Tigroid body) is a large granular body found in nerve cells. It was named after Franz Nissl, German neurologist (1860-1919).> Nissl bodies can be demonstrated by selective staining, which was developed by Nissl and was an aniline stain used to label extranuclear RNA granu...
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Ans. is 'c' i.e., Wood workersRef Dhingra 4h/e p. 235; Nasopharyngeal carcinoma By Andrew Van Hasselt,Alan G. Gibb 2d/e p. 4Wood dusts exposure is a risk factor of nasopharyngeal carcinoma andAdenocarcinoma of PNS.Formaldehyde exposure is a risk factor of Nasopharyngeal carcinoma.
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Lymphomas may arise as a primary B-cell lesion in the brain in a manner analogous to its occurrence in the stomach, small bowel, or testis, but the overwhelming majority of lymphomas are metastatic to the brain from other sites. Primary lymphoma of the brain often originates deep in the cerebral hemispheres, commonly i...
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They are the major adhesion complexes in the epidermis. Desmosomes bridge adjacent keratinocytes and allow cells to withstand trauma. Keratinocytes are created in the lower layers of the epidermis and operate with a phospholipid cell membrane, which can be quite permeable. When the keratinocytes are pushed to the strat...
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Refractory ascites can be managed by: Trans-jugular intra-hepatic peritoneal shunt (TIPS) Serial large volume paracentesis (LVP) with albumin. TIPS is superior to LVP in reducing the re-accumulation of ascites but is associated with an increased frequency of hepatic encephalopathy Extra Edge: Diagnostic criteria for re...
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Ans. is 'c' i.e. Scrapings from ulcer for dark field microscopy [Ref.: Harrison 16/e p 981 (15 /e p. 1046, 1047)Single painless ulcer on external genitalia in young male is suggestive of syphilis the patient is in the first stage of syphilis. The single painless ulcer is primary chancre.Diagnosis of syphilisAbsolute di...
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In patients of Alkaptonuria, Vitamin C may decrease deposition of brown pigment in cartilage. Hence it is used.
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Parenteral: Cefotaxime ,Ceftizoxime ,Ceftriaxone ,Ceftazidime, Cefoperazone Oral :Cefixime, Cefpodoxime proxetil ,Cefdinir Ceftibuten, Ceftamet pivoxil ESSENTIALS OF MEDICAL PHARMACOLOGY page no.726
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A i.e. Bombay
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VSD
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Creep is defined as the time dependent plastic strain of a material under a static load or constant stress.  For a given load at a given time, the low-copper amalgam has a greater strain. The implications and clinical importance of this are that the greater creep in the low-copper amalgam makes it more susceptible to s...
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.
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No treatment other than observation is advised. Further the patient should be educated that such sinus may get infected or form a cyst. Surgery is advised if sinus is symptomatic.
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Ans BIn general smaller the focal spot sharper the image Routinely focal spot size 0.3x0.3mm while magnification technique small focus of 0.1x0.1mm is used.
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Urobilinogen is formed by bacterial metabolism in the gut from conjugated bilirubin. Following secretion into bile, conjugated bilirubin reaches the duodenum and passes down the GIT without reabsorption by the intestinal mucosa. Hence it is absent in urine in obstructive jaundice. Urinary Urobilinogen is increased in h...
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ANSWER: (A) Alzheimer's diseaseREF: Harrison's Internal Medicine 17th ed> Chapter 365. DementiaAlzheimer's disease most often presents with subtle onset of memory loss followed by a slowly progressive dementia that has a course of several years. Pathologically, there is diffuse atrophy of the cerebral cortex with secon...
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A i.e. CPEO
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Primary Structure: Primary structure is the linear sequence of amino acids held together by peptide bonds in its peptide chain. The peptide bonds form the backbone and side chains of amino acid residues project outside the peptide backbone. The free -NH2 group of the terminal amino acid is called as N-terminal end and ...
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According to EAST Guidelines “Current recommendations for nonoperative management of penetrating trauma include use of Triple Contrast CT (IV, oral and rectal) and serial examinations.” • Gunshot Abdominal Wounds: −− Chances of internal injury is very high in gunshot wounds, thus little pre-operative evaluation is requ...
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c. Duodenal atresia(Ref: Nelson's 20/e p 610-615, Ghai 8/e p 637-639)Most common cause of Intestinal obstruction in Down's syndrome is duodenal atresia.
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Bruxism synonym. Neuralgial traumatic (Karolyl) Karolyi effect (Weskit) Occlusal habit neurosis (Tischer) Parafunctional occlusal habit (Drum) According to Ramjford and Ash, BRUXISM is triggered by: Emotional tensions Occlusal maladjustment Pain / discomfort
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In this test air conduction of the ear is compared with its bone conduction. It is a test for conductive deafness. Rinne Positive: AC > BC Rinne Negative: BC > AC (conductive deafness in that ear) Ref: Dhingra; 6th Edition; pg no 22
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Ans. is 'a' i.e., Lorazepam Treatment of alcohol dependenceo Detoxification (treatment of withdrawal) BZDs are the drugs of choice, e.g. chlordiazepoxide (Ist choice), Diazepam (2nd choice).o Maintenance after detoxification (to prevent relapse and maintenance of abstinence)a) Aversive agents (deferent agents) :- Disul...
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Parainfluenza virus
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Natamycin eye drops are the DOC for filamentous fungi (Aspergillus, Fusarium) and amphotericin B is the DOC for candida.
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Recurrent, painful oral lesions and cutaneous lesions in the form of flaccid bullae are characteristic of phemphigus vulgaris Positive Tzanck smear, IgG deposits on direct immunofluoroscence positive nikolsky's sign are features of phemphigus vulgaris. Ref: Textbook of Dermatology, Venereology and Leprology By Devinder...
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Woman in the question stem is suffering from infection caused by Listeria monocytogens. Listeria monocytogenes is a food borne pathogen capable of causing parasitic infections in human. It is a motile, non-spore forming, gram positive, rod shaped bacterium. It is a facultative anaerobe and can grow in vaccum, packaged ...
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Over 75% of rheumatoid ahritis patients repo improvement of symptoms in pregnancy. Generally, the autoimmune disease worsens/ same severity during pregnancy.
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The secondary odontoblasts subsequently generate reparative tertiary dentin (or “reparative dentin”) as a part of the ongoing host defense. Reparative dentin usually appears as a localized dentin deposit on the wall of the pulp cavity immediately subjacent to the area on the tooth that had received the injury. Reparati...
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We cannot calculate coefficient of variance here, because value of mean has not been provided (value of median is given). Only in standard normal curve mean = median. But in that case both are '0' (In standard normal curve mean = median = mode = 0) I am clueless here. It you take, value of median as mean than the answe...
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Neurapraxia is a disorder of the peripheral nervous system in which there is a temporary loss of motor and sensory function due to blockage of nerve conduction, usually lasting an average of six to eight weeks before full recovery.Ref: Ganong&;s review of medical physiology 23rd edition
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The energy used in phacoemulsification is lesser as compared to the senile cataract. Congenital Cataract Surgery Treatment of choice: Lens aspiration by manual SICS technique or by phaco-emucification technique. Lensectomy can be done in total cataract with retinal detachment or ROP or any congenital retinal condition ...
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harshmohan textbook of pathology 7th edition ABO blood grouping shows codominance as both alleles of a gene pair are expressed in heterozygous state
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C i.e. Mutation of genes encoding lysosomal hydrolasesLysosomal storage diseases (LSD) are caused by mutations in genes encoding lysosomal hydrolasesQ responsible for breaking down of macromolecules, which results in accumulation of corresponsing substrate (macromolecule). ISDs are classified on the basis of accumulate...
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Pathophysiology The tumour secretes gastrin, which stimulates acid secretion to its maximal capacity and increases the parietal cell mass three- to sixfold. The acid output may be so great that it reaches the upper small intestine, reducing the luminal pH to 2 or less. Pancreatic lipase is inactivated and bile acids ar...
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This drug is an antagonist of substance p.it is paicularly useful in delayed phase of chemotherapy induced vomiting.(ref Goodman and Gilman 11/e p1005)
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Opsoclonus is a disorder of eye movement characterized by involuntary, chaotic saccades that occur in all directions of gaze. It is frequently associated with myoclonus and ataxia. Opsoclonus-myoclonus may be cancer-related or idiopathic. When the cause is paraneoplastic, the tumors involved are usually cancer of the l...
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Ans. (b) Normal salineRef.-.Harrison 18th ed. / 270Normal saline is the preferred fluid for volume expansion in a crashing patient with un-recordable BP. The main point to be noted is that if ringer lactate is infused in these patients, then lactate in the solution will never reach the liver where it is normally conver...
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Answer- B. 750 - 1500mlBlood loss- 750- 1500 ml
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Ans. is 'c' i.e., Histamine
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Enteroendocrine cells (EEC) secrete key gastrointestinal (GI) hormones such as gastric-inhibitory peptide (GIP), cholecystokinin (CCK) and ghrelin that are involved in nutrient sensing pathways and are often implicated in GI pathology. EEC is also known as I cells. Ref: www.pshysoc.org
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Ans. is 'a' i.e., Neovascularization is maximum by day 5Skin wound healingSkin wounds are classically described to heal by primary or secondary intention.A. Healing by primary intention It occurs in wounds with opposed edges, e.g., surgical incision.The healing process follows a series of sequantial steps : ?Immediate ...
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Sentinel node is a lymph node that is first to receive drainage from a malignancy. Sentinel lymph node biopsy is used in breast carcinoma, melanoma, vulval carcinoma. Ref: Novak, 14th edition, page; 1425-1426
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Bronchiolitis obliterans with organizing pneumonia (BOOP) is a nonspecific reaction to multiple infectious or inflammatory lesions of the lungs. Causes of BOOP include infections (viral and bacterial), chemical toxins, drugs, and collagen vascular diseases. The lungs respond to these agents, causing bronchiolar injury ...
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Devitalisation Formocresol Mummifying paste Electrocautery Preservation Ca(OH)2, Fe2(SO4)3 Glutaraldehyde Regeneration Bone morphogenic protein Tricalcium phosphate
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Cardiac syndrome X (CSX) is typical anginalike chest pain with evidence of myocardial ischemia in the absence of flow-limiting stenosis on coronary angiography. Cannon et al termed this entity, characterized by a decrease in coronary flow reserve without epicardial aery stenosis, microvascular angina. Ref Harrison 20th...
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Ref: KD Tripathi pharmacology 7th edition (page.no: 150) beta blockers used in thyrotoxicosis because Propranalol inhibit peripheral conversion of T4 to T3 Other uses are Hypeension, Phaeochromocytoma, Anxiety, Alcohol withdrawal ,Myocardial infarction, Angina pectoris, Poal hypeension etc
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Larynx & trachea -Stomach, intestines & Spleen -Liver (foamy liver) lings-Brain -Hea - Kidneys, bladder -Prostate, uterus-Skin, muscle, tendon - Bones Larynx is the earliest organQto putrefy. Nulliparous uterusQis the last organQto putrefy, gravid uterus and uterus soon after delivery putrefies rapidly In males, Prosta...
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Ans. D. DeletionClass II mutation : 'Deletion' of phenylalanine amino acid so CFTR protein fails to reach cell membrane
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<p>In iron deficiency anemia ,hemoglobin will be mild to moderate but occasionally it may be marked(less than 6g/dL). In peripheral smear,microcytic hypochromic red cells are seen;target cells ,polychromatic cells, normoblasts are seen.MCV will be less than 80fl & MCH less than 27pg. The marrow hypercellularity is incr...
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ACTH & ADH → Small cell carcinoma (predominantly) PTH               → Squamous cell Ca
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Benzodiazepine have proved the most effective in preventing emergence delirium with ketamine midazolam is drug of choice. Concomitant intravenous propofol and thiopentone decreases incidence of emergence delirium seen with propofol. Previous intravenous glycopyrolate increases the incidence of emergence delerium.
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Ans. (c) Shigella does not ferments mannitol "Members of enterobacteriaceae rcduce nitrates to nitrites, form catalase but not oxidase." Enterobacteriaceae: lmpoant features Features Escherichia Salmonella Shigella Motility by peritrichous flagella + + - Gas from glucose + + - Acid from lactose + - - Acid from sucrose ...
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It is a classic case of Growth hormone deficiency. clinical features of Growth hormone deficiency Short children with normal body proportions Markedly increased subcutaneous fat Delayed skeletal age than chronological age The height age is less than skeletal age and chronological age. Hypoplastic penis and scrotum May...
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There is history of -Disorganized behavior -Hallucinations (talking to self and laughing loudly is most likely a result of patient hearing some voices and communicating with the voices) -The history of disappeared family member is again suggesting that some family member may have had a mental illness because of which e...
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Ans AThe CT criteria for shock bowel are bowel-wall thickening greater than 3 mm and mucosal enhancement greater than the psoas muscle. The finding of a collapsed IVC was defined as an anteroposterior diameter of less than 9 mm on at least three contiguous sections. A collapsed aorta was defined as an anteroposterior d...
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Gastric lavage (stomach wash) is given to prevent aspiration of contents.
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Schistosomiasis, also known as snail fever and bilharzia, a disease caused by parasitic flatworms called schistosomes. The urinary tract or the intestines may be infected. Signs and symptoms may include abdominal pain, diarrhea, bloody stool, or blood in the urine. Those who have been infected a long time may experienc...
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Glioblastoma multiforme (GBM) is the most frequent primary malignant tumor of the CNS. It usually affects middle-aged or elderly patients and most frequently arises in the cerebral white matter. GBM is a malignant astrocytoma; it is referred to as grade IV astrocytoma in the WHO classification and grade 4 astrocytoma i...
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Atlanto - occipital (between the skull and C1) joint permit nodding of the head (as when indicating approval or yes) and Atlanto-axial joint permits the head to be turned from side to side i.e. rotation (as indicating disapproval, the no movement).
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Paograph is a graphical record of cervical dilatation and descent of head against the duration of labour in hours. It gives information about fetal and maternal condition which is recorded in a sheet of paper. Ref: Datta Obs 9e pg 122.
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- Mental retardation is not a feature of Acquired hypothyroidism - It is seen in child with untreated congenital hypothyroidism Clinical features of acquired hypothyroidism: Firm & nodular goiter Deceleration of growth is usually the first clinical manifestation Cold intolerance Lethargy Constipation Delayed dentition ...
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As EDTA interferes with hard tissue generation capacity of MTA.
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Organochlorine insecticides are chlorinated hydrocarbons and are divided into four types as:* DDT (dichlorodiphenyl-trichloroethane) and analogues* Benzene hexachloride group -- e.g. BHC, lindane* Cyclodines and related compounds -- e.g. endrin, aldrin,dieldrin, endosulfan, sobenzan{ polycyclic polychlorinated hydrocar...
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Anterior chamber(AC) - space between the posterior surface of cornea & the Anterior surface of iris. Depth of anterior chamber is measure from center of cornea to center of pupil average 2.5mm shallow AC- in elderly women, hypermetropes deep AC in young males, myopes volume -0.25 to 0.3 ml BOTH AC AND PC CONTAINS AQEOU...
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Ans. is 'c' i.e., Kidney Cyclophosphomide is primarily metabolized (80%) and metabolites are exceed in urine. 10 to 20% is excreted unchanged in urine and 4% is excreted in bile.
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(Multiple myeloma) (191-92-A)Metastatic bone disease - "Moth eaten appearance" in the cortexMultiple myeloma - reduction in density, myeloma is one of the commonest cause of secondary osteoporosis and vertebral compression fracture* Multiple punched-out defect with no marginal new bone around them
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The subscapularis muscle is inseed on the lesser tubercle of the humerus. Forceful contraction of subscapularis muscle to resist the abduction and external rotation of the shoulder may cause an isolated avulsion fracture of lesser trochanter. Ref : Gray's Anatomy The Anatomical Basics of Clinical Practice 41e pg 806.
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Lysosomes has all the three functions ie. autophagy, autolysis and digestion
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Among the given options, the drug with longest half life is moxifloxacin (around 12 hours) but overall longest acting is sparfloxacin. Half-life of fluoroquinolones Drug Half Life Drug Half Life Ciprofloxacin 4 hours Norfloxacin 3 hours Gatifloxacin 7-8 hours Levofloxacin 7-8 hours Lomefloxacin 8 hours Moxifloxacin 12-...
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D i.e. Pethidine * In anaesthesia, shivering occurs as a protective mechanism as inhalational agents, spinal/epidural block causes vasodilatation leading to heat loss. Shivering can be abolished by inhibition of hypothalamus. Halothane most commonly leads to shivering. Treatment of shivering 1. Pethidine or pentazocine...
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D ref: Ahuja, 4th/e p. 13 and 5th/e p. 252
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Ans. (b) Carboplatin + Etoposide + VincristineRef: Ryan's retina 6/e, p. 2392; Kanski 8/e, p. 502; Parson's 22/e, p. 381Chemotherapy agents commonly used for treatment of retinoblastoma are Age <= 36 monthsAge > 36 monthsVincristine0.05 mg/kg1.5 mg/m2Etoposide5 mg/kg150 mg/ m2Carboplatin18.6 mg/kg560 to 600 mg/m2
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(D) Involvement of Dorsal mid-brain[?]WEBER'S SYNDROME (superior alternating hemiplegia) is a form of stroke characterized by the presence of an ipsi-lateral oculomotor nerve palsy and contra-lateral hemiparesis or hemiplegia.oIt is caused by mid-brain infarction as a result of occlusion of the paramedian branches of t...
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D i.e. Binding of aminoacyl tRNA uses 2ATP- Component of 50s subunit are 23s & 5s; and components of 60s subunit are 28s, 5.8s and 5s.Ribosome is a highly conserved natural machine for protein synthesis that brings m-RNA & t-RNA togetherQ. It has 2 subunits the large subunit catalzes peptide bond formation whereas smal...
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This child has acute diarrhea with some dehydration. So, the treatment of choice is ORS with zinc for 14 days. For treatment of some dehydration, 75 ml/kg ORS has to be given over 4 hours.
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Answer is A (Prolonged flow through mitral valve) Loud SI in mitral stenosis results from prolonged AV flow through the mitral vain `S1 is louder i fAV flow is prolonged because of mitral stenosis' -- Harrison Reduced mobility of valve (Immobility, calcification), and Prolonged PR interval (1st degree block) are all ca...
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B. burgdorferi, the causative agent of Lyme disease, is a fastidious microaerophilic bacterium. Louse-borne relapsing fever (LBRF) is caused by Borrelia recurrentis. To maintain its complex enzootic cycle, B. burgdorferi must adapt to two markedly different environments: the tick and the mammalian host. Epidemiologic s...
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Ans. C. Colle's Fracture. (Ref Maheshwari orthopaedics 3rd/pg. 24 & 139)Maheshwari orthopaedics 3rd/pg. 24 mentions........................|||Tension-band wiringTension-band plateTension-band fixation|||iUsed for producing dynamic compression in Patella, Olecranon & transverse malleolus .Used for Humerus & Tibia .Used ...
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Ans. is 'c' i.e., Causes hyperglycemia Quinine* It is levo rotatory alkaloid obtained from cinchona bark. Its d-isomer quinidine is used as an antiarrhythmic. Quinine is an erythrocytic schizontocide for all species of plasmodium. Quinine has no effect on pre and exoerythrocytic stage. Mechanism of action is similar to...
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Suspect - injury of kidney in left abdomen. MCU is IOC for Vesicourethral Reflux IVP is IOC for Ureterocele
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A primary injury is caused by a direct effect of blast overpressure on tissue. Primary blast injury affects air-filled structures such as the lungs, ears, and GI tract the following mechanisms: spalling (e.g., from lung parenchyma to alveolar space, causing tissue surfaces to explode geyser-like); shearing, due to diff...
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Antrochoanal polyp originates from within the maxillary antrum, comes out of its accessory ostium into the nose and then grows towards the nasopharynx.Earlier it was removed in adults by Caldwell-Luc operation to excise its antral origin to prevent recurrence. Caldwell-Luc operation is avoided in children so as not to ...
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Transection of the brainstem at the midpoint level with bilateral vagotomy causes apneusis. At mid pontine level lesion, the apneustic centre is intact while the pneumotaxic centre is seperated. Concurrent removal of vagus inputs causes this kind of abnormal pattern of breathing characterized by deep, gasping inspirati...
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Ans. c. von-Willebrand factor (Ref: Robbins 9/e p117,118. 8/e p116-118)Platelet adhesion to collagen occurs via von- Willebrand factor)'Endothelial injury allows platelets to contact the underlying extracellular matrix; subsequent adhesion occurs through interactions with von Willebrand factor (vWF), which is a product...
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A prolonged BSP dye excretion test is diagnostic of Dubin Johnson syndrome BSP is a dye which is removed from circulation by the same mechanism as bilirubin. Reference Harsh mohan page no.593
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Anencephaly
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This patient develops urticaria after:- Exercise Exposure to sunlight → generalized heating Both of these provoke cholinergic urticaria due to stimulation of cholinergic sympathetic fibres.
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In 95% of cases of Down Syndrome - trisomy of 21 Extra chromosome is of maternal in origin 1% have mosaic with 46 chromosomes 4% have Robertsonian translocation. t(13:21) t (14 : 21) t (15 : 21) Very rarely long arm of chromosome 21 is triplicate (Partial trisomy)
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Phosphorylase, Glucan transferase, Debranching, Phosphorylase Enzymes of glycogenolysis come into play in the following sequence : (i) Glycogen phosphorylase → (ii) Glucan transferase → (iii) Debranching enzyme.
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