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GVHD characteristically involves liver, gastrointestinal tract and skin. It occurs as a complication of hematopoietic stem cell transplant when immunocompetent cells and precursors recognize host tissue alloantigens and react against them.
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Ans. is d i.e. Stage I C
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B i.e. Steroids best treat skin lesions Presence of palpable (non-blanching) purpura, mainly involving dependent areas such as buttocks & lower extremities in children & adolescents (along with ahralgia; gastrointestinal bleedin colic abdominal pain, hematuriaQ, and histo pathological demonstration of extra /peri- vasc...
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Osteoclasts are responsible for bone resorption. They are multi-nucleated cells These cells are derived from the mononuclear hematopoietic progenitor cells
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Fordyce's granules these are heterotropic sebaceous glands occurring in the oral mucosa. They present either as yellow-white point points, usually in the buccal mucosa or as plaque-like configurations They have no significance and no treatment is required.
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For acidic drug poisoning like (barbiturates, salicylates and methotrexates) ,urinary alkinization agents are prescribed where as basic drug poisoning (morphine, amphetamine ,atropine etc) urinary acidification agents are prescribed. Refer Ltd 7/e p29
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Human embryology Tenth edition Inder Bir Singh Page no 301 The genital tubercle becomes cylindrical and forms the clitoris Genital tubercle is situated in the midline between the urogenital membrane and lower pa of anterior abdominal wall In males genital tubercle forms penis
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A frontal headache when waking up in the morning and a computerized tomography (CT) scan showing a frontal lobe mass with focal areas of calcification are characteristic findings in oligodendrogliomas, which commonly involve the frontal lobe. These are tumors derived from oligodendrocytes that frequently locate in the ...
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Ans. is 'b' i.e., Hydrolytic enzyme Eosinophils produce o Major basic protein o PAF o Neurotoxin o Reactive oxygen species o Leukotrienes o Peroxidase o Eosinophilic cationic protein
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Ans. is 'b' i.e., Cefotixin disc diffusionOxacillin (also methicillin) resistance is detected by finding the presence of mec A gene."Cefoxitin disc diffusion has been repoed to more occurately predict mec A gene presence than oxacillin disc diffusion."The use of cefoxitin MIC test has not been recommended by the CLSI-A...
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Sampling error is a type of variation between one sample to another. Due chance and concern either incorrect acceptance or rejection of null hypothesis. Sampling errors arises because it is based on a pa and not on the whole. There are two types of sampling errors Type I or alpha error and type II or beta error. The qu...
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Ans. is 'd' i.e., Diabetes insipidus Hypeonic saline infusion test that induces plasma hyperosmolality. Used for distinguishing between different causes of polyuria and polydipsia.
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Interconnection between greater sac and lesser sac of peritoneum is known as Foramen of Winslow. It has the following boundaries: Superior boundary: Caudate lobe of liver Anterior boundary: Free edge of lesser omentum containing common bile duct, hepatic aery andpoal vein. Inferior boundary: First pa of duodenum Poster...
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C-X-C chemokines have one amino acid residue separating the first two of the four conserved cysteine residues. It is induced by microbial products and other cytokines, mainly IL-1 and TNF. These chemokines act on neutrophils primarily. IL 8 is typical of this group. It is secreted by activated macrophages, endothelial ...
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Ans. (c) 40 yearsRef: Textbook of Forensic medicine and Toxicology: Principles and Practice, 5/e, p 43
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Ans. is 'd' i.e., Kidney disease Plummer-Vinson syndrome* Plummer-Vinson syndrome, also known as Brown-Kelly-Paterson syndrome or sederopenic dysphagia, seen in middle aged edentulous women.* The plummer Vinsion Paterson Brown Kelly Syndrome is characterized by: -# Dysphagia# Chronic iron deficiency anemia# Atrophic or...
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Enriched Media - When a basal medium is added with additional nutrients such as blood, serum or egg, it is called enriched medium. They suppo the growth of fastidious bacteria, eg - Blood agar Chocolate agar Loeffler's serum slope Indicator media - Contains indicator that give specific colour / characteristic to growin...
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Ans. (d) Total thyroidectomy + Prophylactic Central Neck Node dissection (CND)Ref: Schwartz 10th Edition Page 1549* Routine Central neck node dissection must be done for Medullary cancers of Thyroid.
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Most complications of measles involve the respiratory tract and include the effects of measles virus replication itself and secondary bacterial infections. Many children with measles develop diarrhea. Otitis media and bronchopneumonia are also common. Rare but serious complications of measles involve the central nervou...
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Cholesterol is first changed to form pregnenolone (common pathway). For this free cholesterol is released in the cytosol from cholesteryl esters of cytoplasmic lipid droplets and transferred into mitochondria. An enzyme called "cytochrome-P- 450-sidechain cleavage" enzyme (P450 sce) present in inner mitochondrial membr...
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"The rapid elimination of desflurane make it the inhalational anaesthetic of choice for elderly patients". — Morgan
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Testicular feminization is a disorder of the androgen receptor. Phenotypically, the patient appears female, but has a blindly ending vagina and lacks a uterus or other female internal reproductive organs. The patient has an XY genotype. Since the gene for testes determining factor (TDF) is on the Y chromosome, TDF will...
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Hemoglobin A1c elevation occurs in diabetes mellitus. The patient has complications of type 2 diabetes mellitus that are typical of obesity: a "diabetic foot" as a consequence of peripheral neuropathy and decreased sensation, advanced atherosclerosis with carotid arterial occlusion, and an atherosclerotic aortic aneury...
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X-ray findings of increased intracranial tension: Sutural diastasis Sellar demineralization Erosion of posterior clinoids Silver beaten appearance Must know: Cushing's triad: It is the classic presentation of ICH: hypeension, bradycardia, and irregular respirations. Ref: Diagnostic Neuroradiology edited by Valery N.Kor...
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Exposure to ceain drugs is the third most common frequent cause of pancreatitis after gallstones and alcohol. Drugs associated with pancreatitis: Definitive cause 5- Aminosalicylate 6- Mercaptopurine Azathioprine Cytosine arabinoside Dideoxyinosine Diuretics Estrogens Furosemide Metronidazole Pentamidine Tetracycline T...
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Normally Bradykinin is Metabolized by Angiotensin converting enzyme and increased levels of Bradykinin is seen with after administration of ACE inhibitors, which leads to dry cough. And it is not seen with APB's as they directly block the Angiotensin receptor, without inhibiting enzyme.
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Answer- B. Neoadjuvant chemotherapy followed by radical cystectomy
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Ans. is 'b' i.e., Prolactin deficiency Bromocriptine is used in :-Suppression of lactation in galactorrheaCyclical mastalgiaInduction of ovulation in anovulatory infertility caused by hyperprolactinemiaParkinsonismAcromegaly due to small pitutary tumoursHepatic comaRecently, it has been approved for treatment of type 2...
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Ans. is 'b' i.e., Red bag
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Refer Robbins page no DeQuervains thyroiditis is also referred to as Granulomatous thyroiditis
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*Enzyme-linked immunosorbent assay (ELISA) and Western blotting are used to initially detect HIV-specific antibodies but these tests are not used for diagnosis in patients younger than 18 months of age. *This is because of the persistence of the maternal HIV antibody in infants younger than 18 months. Infants younger t...
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The epithelium of the urethra stas off as transitional cells as it exits the bladder. Fuher along the urethra there are psuedostratified columnar and stified columnar epithelia, then stratified squamous cells near the external urethral orifice. There are small mucus-secreting urethral glands, that help protect the epit...
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Ans. D. 10 daysStreptococcal sore throat presents as bilateral tonsil hypertrophy and erythema, with characteristic exudates. Treatment is with 10 days course of Penicillin V or a first generation cephalosporin.
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BMI stands for the Body Mass Index which is used to predict weight for the respective height. It is defined as the weight in kilograms divided by the square of height in metres and is expressed as kg/m2. A value of BMI > 30 is classified as obesity and a BMI of > 40 is classified under class III obesity. A BMI > 20 up ...
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Ans. is 'a' i.e., Ahus reaction; 'b' i.e., Bronchial asthma; 'c' i.e., Haemolytic anemia
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HEV is not included in Picorna group of viruses. It belongs to Family Caliciviridae. Rhinovirus, HAV and Polio virus belong to the Family Picornaviridae. Characteristics of the Family Picornaviridae: Very small ( pico: measuring small; rna: RNA virus) RNA viruses. The genome consists of a single linear molecule of sing...
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% of CoHb Clinical features 0 - 10 No symptoms 10 - 20 Tightness across forehead Slight headache Dilatation of cutaneous blood vessels 20 - 30 Headache Throbbing in temples 30 - 40 Severe headache Weakness Dizziness Dimness of vision Nausea and vomiting Collapse 40 - 50 Same as above plus greater possibility of collaps...
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Secondary attack rate is defined as the number of exposed persons developing the disease within the range of incubation period. It was initially developed to measure the spread of an infection within a family,household or any closed aggregate of persons who have had contact with a case of disease (refer pgno:100 park 2...
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BCL- 2 inhibitor used in CLL is Venetoclax. It works by promoting apoptosis. CLL - Most common Blood Cancer (leukemia) in Adult population. Rx- Chemoimmunotherapy + Monoclonal Antibody F C R Fludrabine Cyclophosphamide Rituximab P C R Pentostatin Cyclophosphamide Rituximab
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The lesion describe in this case is hypostasis. It occurs in the most dependant pas of the body. It is caused due to distension of blood vessels in the dermis. It is absent in areas under pressure. Ref: Textbook of Forensic Medicine and Toxicology by Narayan Reddy, Edition 21, Page - 154
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Post prandial (fed state) utilization of glucose, it is done by Glucokinase enzyme. In other words, The main enzyme which works on glucose after a meal is glucokinase as glucose is present in abundance under this condition. Hexokinase due to its low Km and High affinity for glucose can work even if glucose concentratio...
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Erythromycin
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Ans. is 'd' i.e., HLA-B8 o HLA-B8 is associated with Myasthenia gravis and Grave's disease.About other optionso HLA 51 is associated with Behcet's disease. o HLA 47 is associated with congenital adrenal hyperplasia.o HLA-B27 is associated with seronegative spondyloartropathies (ankylosing spondylitis, Psoriatic arthrit...
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CT scan is based on Linear attenuation of Xrays/stopping power of various tissues, which is based on its density and is measured in Hounsfield Units. Pulse-Echo principle and Piezoelectric effect are used in USG. Coincidence imaging is used in PET scan.
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Ans. is 'a' i.e., To know total number of cases o The sentinel data is extrapolated to the entire population to estimate the disease prevalence in the total population. So, it helps in estimating the total amount of disease in a community.
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Ans. is 'b' i.e., Tensor tympani Tensor tympani is derived from 1" arch.
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Virchow's lepra cells or foamy cells are undifferentiated histiocytes.
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Congenital anomalies associated with an increased risk of bladder cancer are: patent urachus exstrophy bladder Both increase the risk for adenocarcinoma.
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Zoological layer
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Compliance is defined as the change in volume for a unit change in pressure. It measures the distensibility or, stretchability of lung The total compliance of both lungs together in the normal adult human averages about 200 milliliters of air per centimeter of water transpulmonary pressure. The compliance of the combin...
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SERIAL INTERVAL is the gap in time between the onset of the primary case and the secondary case.it helps to get a distribution of secondary cases from which we can guess the incubation period of diseasered:park's textbook of preventive and social medicine,22 nd edition,pg no 96
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Colposcopic signs: → Margin → Color → Vessels → Iodine staining.
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Human chorionic gonadotropin (hCG) is produced in large quantities by the human placenta. It is used as a pregnancy indicator around 2-weeks post copulation. This hormone is composed of an alpha and a beta subunit. Like other gonadotropins, hCG is also glycosylated which influences biological activity. Human chorionic ...
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Minimum alveolar concentration is defined as the alveolar concentration of an inhaled anesthetic agent that prevents movement in 50% of patients in response to a standardized surgical stimulus. Low MAC - High potency MAC values of adult Halothane: 0.75 Sevoflurane: 2.0 Isoflurane: 1.2 Desflurane: 6.0 Enflurane: 1.7 Xen...
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Drug safety Pharmacovigilance is defined as "All methods of assessment and prevention of adverse drug reactions". National pharmacovigilance program (India) 2004 India's drugs control depament within the ministry of health and family welfare initiated the establishment of a nationwide network to build a comprehensive p...
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Vaccination is aificial active immunity. Active immunity is associated with immunological memory. It is produced actively by host's immune system. Reference : Anathanarayan & paniker's 9th edition, pg no:82,83 <\p>
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X ray and bone marrow biopsy is usually taken to diagnose Multiple myeloma. Paraproteinemia can cause an elevated ESR even though not specific. But usually bone scan is not done because sensitivity is low when compared to X ray. Reference : Davidson, 23rd Edition, page no : 967.
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"Aseptic meningitis may develop before, during, after or in the absence of parotids." - Harrison 17th/e-1220 About other options Mainly parotid glands are involved, but sublingual and submaxillary glands may also be involved. The patient is infectious 4-6 days before the onset of swelling. Sterility after mumps orchit...
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ANSWER: (A) 1/3rd of tidal volumeREF: Guyton physiology 11th edition page 478, http://en.wikipedia.org/wiki/Dead_space_%28ph ysiology%29Indirect repeat in December 2010"The normal dead space air in a young adult man is about 150 millilitres. This increases slightly with age1'Some of the air a person breathes never reac...
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Agar, a polysaccharide extract of a marine alga, is uniquely suitable for microbial cultivation because it is resistant to microbial action and becauseit dissolves at 100degC but does not gel until cooled below 45degC; cells can be suspended in the medium at 45degC and the medium quickly cooled to a gel without harming...
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Ans. is 'b' i.e., Reabsorption of water in DCTAntidiuretc hormone t Vasopressin)o Antidiuretic hormone reduces the rate of urine formation.o ADH is synthesized predominantly in the supraoptic nucleus of the hypothalamus, along with its binding protein neurophysin I.o The most important stimulus for the secretion of ADH...
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Classical markers for Hodgkin's disease are CD15 and CD30. CD15 and CD30 are positive in all variants of Hodgkin's disease except lymphocyte predominance. Lymphocyte predominance variant is positive for CD20.
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Fever right shifts the oxygen dissociation curve, which allows for a greater release of oxygen to the tissue, making oxygen easily available to neutrophils and monocytes for use in the oxygen-dependent myeloperoxidase system of bactericidal killing. Having more oxygen available to tissue also enhances wound healing. In...
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Ans. C: Ancylostoma duodenaleAn adult Ancylostome (hookworm) can suck about 0.2 ml blood a day, while the smaller necator sucks in about 0.03 ml per day. These worms frequently leave one site and attach themselves to other site. As the secretions of the worm contain anticoagulant activity, bleeding from the site may co...
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The activity of the antioxidant enzymes depends on supply of minerals : Manganese Copper Zinc Selenium Manganese, copper and zinc are required for the activity of superoxide dismutase. Selenium is required for the activity of glutathione peroxidase. REF: ROBBINS pathology 10th edition
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Answer is A (Cervical): Rheumatoid ahritis commonly involves the joints of hands, wrist, elbow, knees, ankle, and feet in a symmetrical manner. Axial skeleton involvement is usually limited to Upper Cervical Spine.
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Ans. (a) Octreotide* DOC in management of Acute Variceal Bleed- Octreotide* Terlipressin is released in sustained manner - may also be used to control variceal bleeding (better than Vasopressin)
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Examination of the peripheral blood reveals erythrocytes with a membrane defect forming "bite" cells; when crystal violet stain is applied, many Heinz bodies are seen. Glucose-6- phosphate dehydrogenase (G6PD) is an enzyme of the hexose monophosphate shunt pathway that maintains glutathione in a reduced (active) form. ...
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Osteochondroma usually presents as a painless swelling. The occurrence of pain suggests some complications such as : Bursitis at the tip of the swelling. Fracture through the stalk of the osteochondroma Impingement on or tethering of neighbouring structures such as a tendon, muscle or nerve. Malignant transformation
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Ans. is 'c' i.e., RhabdomyosarcomaRhabdomyosarcomao The most common soft tissue sarcoma in children is rhabdomyosarcoma.The common site of involvement are:o Head & Neck (25%) -Most commono Genitourinary (22%) - 2nd most commono Extremitieso Retroperitoneum.o Rhabdomyosarcoma is the most common nonocular orbital tumor i...
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Coagulation testing is mainly done for: * Warfarin(vitamin K antagonist) : it is monitored by prothrombin time(PT) or International Normalised Ratio(INR). * Unfractionated Heparin : it is monitered by aPTT. Other anti-coagulants requiring monitoring are direct thrombin inhibitors like: * Lepirudin * Bivalirudin They re...
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CAROLI'S DISEASE is congenital, nonfamilial, multiple, irregular, dilatation of the intrahepatic ducts with stenotic segments in between. It is associated with congenital hepatic fibrosis and medullary sponge kidney. * It can also be included under type V choledochal cyst.it is a hepatic cause of poal hypeension. ref: ...
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Blood → 30 ml (minimum 10 ml) Urine →  30 ml
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C i.e. Sphenoid Sinus Pleural effusion is best visualized by X Ray in decubitus posture (on same side of pleural effusion). Ipsilateral lateral decubitus is investigation of choice for minimal pleural effusionQ Ipsilateral (Same sided) lateral decubitus view leads to collection of even minimal fluid in the lateral pleu...
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Ans. A i.e. Single bubble appearance
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Ans. is 'a' i.e. It should be stored in deep freezer This question is framed to test our knowledge about storage of vaccines 'which vaccines are freezed andwhich never allowed to freeze.The other options are given just to create confusion.So learn by heartVaccines which are stored in deep freezerPolio*Measles*Vaccines ...
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Ref:The essential of forensic medicine and toxicology Dr.K.S NARAYAN REDDY 32nd edition pg no 415 the stain is estracted by 10% HCL and a drop is placed on a glass slide and allow to dry a cover slip is place dover this , and a drop of florence solution(KI,iodide and water) this allowed to run under the cover slip .if ...
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Volume Indicators Total body water 3H2O, 2H2O, Antipyrine Extracellular fluid 22Na, 125I-iothalamate, thiosulphate, inulin ICF (calculated as TBW-ECF) Plasma volume 125I-albumin, Evans blue dye Interstitial fluid (calculated as ECF-plasma volume) Blood volume Cr-labeled red blood cells
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Stage of Ca is the most important prognostic factor.
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Ref: K. Pork. Textbook of Preventive and Social Medicine,. 22nd edition. P 790Explanation:Mean, median and mode are the measures of central tendency.Mean:It is calculated by summing all the observations and then dividing by number of observations. It is generally denoted by .x. It is calculated as follows.Mean (x) = Su...
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Ans. a (Ewing's sarcoma) (Ref. RRM Radiology, 6th ed., p.)The four main types of rosettes in pathology :1. Homer Wright rosette: typically seen in neuroblastomas, medulloblastomas, and primitive neuroectodermal tumors (PNETs). It consists of a halo of tumor cells surrounding a central region containing neuropil.2. Flex...
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TularemiaAnaplasmosisBabesiosisLymes diseaseEhrlichiosisRocky Mountain Spotted fever Q fever in humans spread by breathing in dust that has been contaminated by infected animal faeces, urine, milk, and bih products. Ref : Park 23rd edition Pgno : 780
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Economic Evaluation:
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NO is a sho-lived, soluble, free radical gas NO is synthesized de novo from L-arginine, molecular oxygen, and NADPH by the enzyme nitric oxide synthase three isoforms of NOS are present Type I, neuronal NOS (nNOS)- present in Neurons, does not play a significant role in inflammation. Type II, inducible NOS (iNOS)- indu...
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The disease is desquamative interstitial pneumonitis (DIP), which is an idiopathic process related to idiopathic interstitial fibrosis. DIP may respond to steroid therapy but may also progress to end-stage lung disease. The lamellar (layered) bodies within macrophages contain surfactant derived from type II pneumocytes...
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Electrophoretic mobility is a common affinity electrophoresis technique used to study protein-DNA or protein-RNA interactions Always number '1' is having maximum electrophoretic mobility. LDH-1 and CK-1 have maximum electrophoretic mobility. LDH-2 has maximum concentration in blood, that's why peak is highest.
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Ans. is 'b' i.e., Blood tellurite media
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Epispadias is a rare type of malformation of the penis in which the urethra ends in an opening on the upper aspect (the dorsum) of the penis. Ref: CDST, 12th Edition, Page 631; Urology by Macfarlane, 4th Edition, Page 252; Bailey and Love's Sho Practice of Surgery, 25th Edition, Page 1363; Visual Handbook of Pediatrics...
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Renal aeriolar changes in malignant nephrosclerosis (malignant hypeension) include fibrinoid necrosis of aerioles (necrotizing aeriolitis), hyperplastic aeriolosclerosis (onion-skinning), necrotizing glomerulitis, and often a thrombotic microangiopathy. Grossly, multiple small petechial hemorrhages are found on the sur...
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D i.e. Ahroscopy
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Nodular glomerulosclerosis also called Kimmelstein wilson nodules are Pathognomonic of Diabetic Nephropathy.
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If heated above 700 degree centigrade then CO & SO2 are formed.
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Growth hormone, Testosterone, aldosterone will decrease with aging, but prolactin level increases with aging. Ref:Harrisons Principles of Internal Medicine, 18th Edition, Page 575
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Structures passing through the medial aspect of the sinus: 1. Internal carotid aery with the venous and sympathetic plexus around it. 2. Abducent nerve: inferolateral to the internal carotid aery The structures in the infra lateral wall and on the Lasseter medial aspect of the sinus are separated from blood, by the way...
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Emotional behaviour is one of the most impoant functions of the limbic system. Emotions refer to an aroused state involving intense feeling, autonomic activation and related behaviour, which accompany many of our conscious experiences. Emotions have two major components: mental and physical. - MENTAL OR SENSORY COMPONE...
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Ans is 'd' i.e. Mass media According to Alma-Ata declaration (1978), "Health education is a process aimed at encouraging people to want to be healthy to know how to stay healthy to do what they can individually and collectively to maintain health and seek help when needed".Health education is the act of getting people ...
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Ans. Malignant melanoma
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Proptosis after trauma, late presentation ,scleral hyperamia, most probable diagnosis is Retrobulbar hematoma . Refer khurana 6/e 404
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Selective estrogen receptor modulators (SERMs) Tamoxifen citrate Mech of action:- It acts as potent estrogen antagonist in breast carcinoma cells, blood vessels and at some peripheral sites, but as paial agonist in uterus, bone, liver and pituitary. Inhibition of human breast cancer cells and hot flushes reflect anties...
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About 60% of HS cases results from a defect in the ankyrin-spectrin complex , with genes for a or b subunits of spectrin dimer (SPTA1 ,SPTB) or for ankyrin (ANK1)being implicated in diff genetic type. 25% ~> involve deficiency in band 3, the anion channel. Ref:Postgraduate Hematology by Victor Hoffbrand ,pg:131 Ref Rob...
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