id
stringlengths
30
30
corpus
stringclasses
3 values
sentence
stringlengths
22
724
token
stringlengths
8
29
complexity
float64
0.03
0.98
difficulty
stringclasses
5 values
3ZC62PVYDHATVMOMZJSVD0UPEAMXXE
bible
The children of the Levites bore the ark of God on their shoulders with the poles thereon, as Moses commanded according to the word of Yahweh.
poles thereon
0.7
difficult
337F8MIIMZDU0UU1CW1J7BAGB8W40B
bible
They each took his censer, and put fire in them, and laid incense thereon, and stood at the door of the Tent of Meeting with Moses and Aaron.
incense thereon
0.7
difficult
3PGQRAZX02KAZASXA58AX6K611ESY7
bible
You shall prepare a meal offering with it morning by morning, the sixth part of an ephah, and the third part of a hin of oil, to moisten the fine flour; a meal offering to Yahweh continually by a perpetual ordinance.
perpetual ordinance
0.723684
difficult
3N7PQ0KLI5P89OQRKPVFIVKER9AE3M
bible
neither to pay attention to myths and endless genealogies, which cause disputes, rather than God's stewardship, which is in faith--
endless genealogies
0.736111
difficult
3NFWQRSHVEE19E2BAFM5J7UN7FVFGE
bible
Because you have had a perpetual enmity, and have given over the children of Israel to the power of the sword in the time of their calamity, in the time of the iniquity of the end;
perpetual enmity
0.75
difficult
3D7VY91L65XBO7MHGGY4DMNZO4QMBO
biomed
We have found similar values for Plg-/- mice in a 50%B6:50%129 background (J. Hoover-Plow, A. Shchurin, and E. Hart, unpublished results).
similar values
0.027778
very easy
3NZ1E5QA6Z1DG01BOHHIWKCD290B5N
biomed
Our results and the sequences we provide will facilitate future global studies of the mechanisms and dynamics of olfactory receptor gene expression.
global studies
0.075
very easy
3XUSYT70IT170QDU572CAF4MOM10DY
biomed
Although great effort was put forth to eliminate non-donor region direct genetic effects, other factors such as maternal genotype (maternal genotype for each congenic versus control dams differed) and environmental effects could confound our results.
other factors
0.075
very easy
3S1WOPCJFGTJU2SGNAN2Y213N78JEH
biomed
Complex traits, such as polygenic growth and obesity are influenced by the small to moderate direct effects of quantitative trait loci (QTL), epistasis between QTL alleles, environmental perturbations and QTL-environment interactions.
direct effects
0.083333
very easy
3RBI0I35XE36FT7IKQ79PYCU9MQY3Y
biomed
As known from the frequent human vWF-syndrome or other haemostatic diseases, small defects often are clinically silent and do not result in physiological changes under normal conditions.
normal conditions
0.1
very easy
32CAVSKPCEPTOH9YNLW1YKRKFE31UD
biomed
It is possible that a reduction in systemic energy utilization, related to the mitochondrial dysfunction, leads to increased fat mass and weight gain in the PGC-1α-/- mice.
weight gain
0.1
very easy
3HRWUH63QU2FH9Q8R7MRNFC7JYEN5O
biomed
The aim in the present study was to determine the location of pendrin and the cause of deafness in Slc26a4-/- mice.
present study
0.1
very easy
3D5G8J4N5A4UAGA7UUQG0CCYL42VT4
biomed
Such contrast enhancement may rest in large part on the particular properties of dendrodendritic synapses between the principal output neurons (mitral cells) and local inhibitory neurons (granule cells) of the olfactory bulb.
large part
0.1
very easy
3K3IX1W4S6RCQ0E22IQ0ZFXOBRGPAS
biomed
In large part, this has been due to the lack of inhibitors capable of specifically down-regulating the calpains without affecting other proteases.
large part
0.111111
very easy
38RHULDV9YFHGRU1QSW887T3HWOWIY
biomed
A recent study by Yoshioka et al. [ 47] showed that misexpression of Fgf9 in chick nephrogenous mesenchyme led to the expansion of gonadal marker gene expression, implicating Fgf9 in gonadal cell proliferation across species.
recent study
0.1
very easy
3YGYP1364194MWO6OEZUQGH3BG3RN6
biomed
Over 30 QTL have been identified in various experiments [1,2].
various experiments
0.1
very easy
3NBFJK3IOHIVFRF49I5V6131ZHXOGM
biomed
A simple bud-like structure initiates the formation of many organs, including lungs, spinal cord, mammary glands, and hair follicles [1].
spinal cord
0.111111
very easy
3KA7IJSNW65H9AJU8WQWUQHUT91PBN
biomed
The possibility has been raised that motor neurons may retrogradely transport NT-3 in muscle to the spinal cord (Chen and Frank 1999).
spinal cord
0.222222
easy
39O6Z4JLX2X1RXJRZ4RDPFX4Y0PXVO
biomed
They found that in the spinal cord of Er81 KO mice, ventral projections of proprioceptive axons were mostly absent, and very few axons made it to the ventral cord.
spinal cord
0.305556
easy
336OE47KI2KM2XE1PZVRNWJXPYKVWU
biomed
Few studies of LCA animal models have extended their examination of retinal pathology to the ultrastructural level.
Few studies
0.111111
very easy
3MQY1YVHS3KLH3IO6YFKYD91IZ92BD
biomed
These data add a new dimension to the complexity of the regulation of the glycolytic pathway, in particular in the CNS, where glycolysis plays a major role in supplying energy and where the proteasome machinery may play a critical role in modulating components of the energy supply machinery [43].
major role
0.132353
very easy
32ZCLEW0BZKNRTH6WO3DSE071EAPJ8
biomed
These transcripts could give rise to defective calpain small subunits with 10-30 inappropriate C-terminal acids, which might be sufficient to support a low level of calpain activity.
low level
0.15
very easy
3QGHA0EA0J07TJGVKI4RMKPQM64WBP
biomed
In HD patients and in accurate genetic replicas, HD CAG knock-in mice, the dominant mutation specifically affects the major population of neurons in the striatum, without impairing huntingtin's essential activities in embryonic development [50-53].
essential activities
0.15
very easy
3RWB1RTQDJNY7CLN5K6M3ORTL3G8P7
biomed
Several studies have used pharmacological manipulations to investigate the contribution of dopamine receptor subtypes in various stages of associative learning [1,2,14].
Several studies
0.161765
very easy
3HUR21WDDUPIVREW4FEXWE1YGHRXYX
biomed
These results suggested that there might be a different mechanism of motor function between swimming and the rotating rod task.
motor function
0.175
very easy
3X4Q1O9UBHMCMY43GF110OQ80EEO7J
biomed
First, the disease may be a result of haploinsufficiency at ITPR1; this concept is consistent with the observation that heterozygous deletion leads to a later onset disorder in humans, whereas homozygous deletion in mice leads to an early onset disorder, able to be expressed within the much shorter life span of the mouse.
life span
0.176471
very easy
39KMGHJ4RZAD16C0TVEHV8K3UXS005
biomed
Therefore, TGFβ and BMP signaling are playing distinct but necessary roles to maintain articular cartilage.
necessary roles
0.180556
very easy
3W1K7D6QSBHBNEL0V5OYLOJ8388BZU
biomed
Huntingtin's large number of diverse cytoplasmic and nuclear protein binding partners strongly suggest that huntingtin may participate in a variety of cellular processes that range from trafficking of growth factor complexes to gene transcription (reviewed in [5,8,9].
large number
0.191176
very easy
3MJ28H2Y1E8XZUQKSMM424CC98JO54
biomed
The different lines examined, however, are very likely to differ genetically from CAPAN-1 cells not only at the BRCA2 locus, but also at a very large number of additional loci.
large number
0.266667
easy
33NOQL7T9OZSLGNTST4OUMT7V2NZ8J
biomed
Since virtually all M-opsin-expressing cells are localized at the outer edge of the ONL by P28 in the rd7 mutant (Figure S8), any increase in M-opsin transcript in the mutant must have occurred in cells in that location.
outer edge
0.194444
very easy
3QQUBC64ZEEOJSAIXD5MFY3RCXONXY
biomed
However, it is noteworthy that the low statistical threshold and small number of animals per group could lead to some false positive results.
positive results
0.196429
very easy
3MVY4USGB6NO9ADS6NM7BIQIBJSIS5
biomed
To date, very few genes have been reported that show species specific alternative splice variants.
few genes
0.196429
very easy
3S1L4CQSFX50ZNP8OFUVNLJK9LTFAF
biomed
A genome database search revealed orthologs of ADAM11, ADAM22 and ADAM23 genes to exist in vertebrates such as mammals, fish, and amphibians, but not in invertebrates.
database search
0.2
easy
3B9XR6P1WEVLNZGWDJLCXUVIKAVJBH
biomed
The pathogenesis of the wide range of metabolic disturbances in MCAD deficiency is poorly understood and certain aspects of patient management are controversial.
wide range
0.216667
easy
34R0BODSP1ZBN3DVY8J8XSIY56D5EH
biomed
Although this property may be a major contributor to the maintenance of lens clarity, the early changes in the alphaA/BKO lenses indicate a much broader cellular function for alpha-crystallin.
major contributor
0.222222
easy
3HXCEECSQMT70MEB5X2ITZH9OHPZYW
biomed
At present, there is no obvious explanation for this result.
obvious explanation
0.222222
easy
3XEDXEGFX3OFEWJ4XOOZESZC8VY0KB
biomed
Mice with Shh overexpression died less than 24 h after birth, probably owing to respiratory failure.
respiratory failure
0.222222
easy
3IVKZBIBJ09ODF28054MB6P3B6DHSB
biomed
By this stage, cholesterol levels were already lower and its immediate precursor, 7-DHC, elevated in the lungs (this study) as well as in the whole body [16,17].
whole body
0.223684
easy
36FFXPMST9O9FNAFTONDR1F2EHAHOE
biomed
Once committed, a small cluster of epithelial cells, the placode, instructs a group of underlying mesenchymal cells to condense and form the nascent dermal papilla, which will be a permanent fixture of the hair follicle.
hair follicle
0.225
easy
3X55NP42EOGC6FFHT3BQC7JI5HO3PA
biomed
In obese patients, skeletal muscle has been observed to have reduced oxidative capacity, increased glycolytic capacity, and a decreased percentage of type I fibers (Hickey et al. 1995; Tanner et al. 2002).
obese patients
0.232143
easy
3WUVMVA7OB3644G8PRO2QDZ2LQNAZY
biomed
Dual color imaging of several GFP variant proteins is a very attractive prospect and has become a standard procedure in cell biology [7,8].
color imaging
0.232143
easy
3S829FDFT21FXGJ58JRJJTRXYTMDX6
biomed
Human patients present with hypoglycemia, hypoketonemia, and nonketotic organic aciduria precipitated by fasting, most frequently during the first 24 mo in life [1].
Human patients
0.233333
easy
3FBEFUUYRK54GUWXNMRRTF67GMQ6A3
biomed
It is interesting that the SOX9 transcription factor continues to be expressed in mutant cartilage despite loss of Col2a1, a direct target of this transcription factor (Bell et al. 1997; Lefebvre et al. 1997).
direct target
0.234375
easy
37S0QRNUFBGD1KM6J34BH2W3WTG88N
biomed
These data evidence a key role for p150CAF-1 during pre-implantation development, and reveal that this protein is required for the proper 3-D organization of heterochromatin within embryonic cell nuclei.
key role
0.25
easy
3S1L4CQSFX50ZNP8OFUVNLJK9LTAFA
biomed
Having excluded a direct role in vesicle formation and membrane fusion, annexin A7 might act by its property as Ca2+-binding protein [17].
direct role
0.234375
easy
356ZPKYPUHHDMIC5IO4G21FVEIJYPB
biomed
Aqp2F204V/F204V mice have dramatically increased urine production, in some cases producing an amount of urine in 24 h that exceeds their body weight, compared to their heterozygous or wild-type littermates.
body weight
0.235294
easy
322ZSN9Z5GKVG3RSAYPTRMCL8K5T4Q
biomed
Sam68 protein expression was observed throughout the developing mouse embryo, in keeping with previous reports that identified the Sam68 mRNA to be widely expressed [38].
previous reports
0.236111
easy
3NFWQRSHVEE19E2BAFM5J7UN7G6GFS
biomed
Although this property may be a major contributor to the maintenance of lens clarity, the early changes in the alphaA/BKO lenses indicate a much broader cellular function for alpha-crystallin.
early changes
0.238095
easy
3WRKFXQBOB7L5WP15TEWT4EJS4OYIZ
biomed
Relevant to gene therapy, recent problems with gene therapy in humans highlight the importance and critical need of animal models of genetic diseases for preclinical studies.
critical need
0.25
easy
30P8I9JKOILSPEZHTY8IXW6K51G5VN
biomed
Past experiments seeking to explore the possible involvement of dopamine D2Rs in associative learning have utilized low to moderate doses of drugs [2,5,6] and site-specific administration [7,9] in order to avoid the confounding effect that locomotor disruption associated with acute D2R blockade can have on learning performance in rodents.
Past experiments
0.25
easy
31J7RYECZLQQ5RM4E7407XV12NA1LJ
biomed
Preliminary data (Wangemann et al., unpublished) support a role for pendrin in HCO3 - secretion into endolymph.
Preliminary data
0.25
easy
304QEQWKZPKY4N4JVGGSL9GLS08O0J
biomed
In MD rat, early death is caused by the dysfunction of the brain stem which is essential for autonomic control of respiration during hypoxia [24].
early death
0.25
easy
3M7OI89LVYOS99TV70NIZAWVGPB6C5
biomed
The initial reports of patients with ESCS attributed the unusual ERG to an abnormally functioning rod photoreceptor system with persistent activity under light adaptation [6–8].
initial reports
0.25
easy
3J94SKDEKIP6VXZV2D8ORA0D5UCD5W
biomed
Similar observations have been made in type 2 diabetic patients (Lillioja et al. 1987; Hickey et al. 1995).
diabetic patients
0.25
easy
3D1UCPY6GG9R0NG07M9FQLOSG7O38Q
biomed
In MRL/Mp mice, the presence of the lpr gene accelerates the development of high level and broad-spectrum auto-Ab production and lethal glomerulonephritis, in addition to marked lymphoproliferative disease.
high level
0.25
easy
3DFYDSXB2W00JYP2DA272KN69V2JUY
biomed
The adult heterozygous females showed a mild tendency toward increased urinary output and water intake and decreased urine osmolality.
mild tendency
0.263889
easy
3XDSWAMB22SLJRCFM91G5FDMGQNCQ8
biomed
Neurotrophin-3 (NT-3) is a key requirement for the development of proprioceptive inputs to motor neurons (Chen and Frank 1999; Chen et al. 2003).
key requirement
0.263889
easy
3JVP4ZJHDPSO81TGXL3N1CKZGR90I0
biomed
To identify molecules essential in ES cells for these properties, several groups have utilized transcriptome analyses to identify genes specifically expressed in ES cells and early embryos.
several groups
0.263889
easy
3SZYX62S5G0QEOYLB052RIQHJJ957V
biomed
Immunoblots of protein extracts from stable cell lines showed that MDCK cells recapitulate the glycosylation defect seen in mutant mice (unpublished data).
unpublished data
0.263889
easy
3L1EFR8WWT5MU4F3W9GVRQ8033B9FU
biomed
Although we have tried to monitor the expression of L-Sox5 or Sox6 in postnatal articular cartilage, and test the phosphorylation state of SOX9 using previously described reagents (Lefebvre et al. 1998; Huang et al. 2000), we have been unable to obtain specific signal at the late postnatal stages required (unpublished data).
unpublished data
0.289474
easy
3SNR5F7R92TNZR8A5S22M1M3ASJIE4
biomed
In support of this view are several studies demonstrating that the disruption of dopamine signaling via acute blockade of dopamine receptors with dopamine receptor antagonists [3-9] or 6-OHDA lesions [1,10,11] do not disrupt phase 1, the palatability or primary reinforcing characteristics of a natural reinforcer (e.g. palatability) but disrupt phase 2, the formation of incentive salience.
several studies
0.264706
easy
3LN50BUKPVBTMJ56Z9FQ8TDZ53FLP6
biomed
However, using homologous recombination in ES cells to generate mutant mice is an inefficient, slow and expensive method because (i) homologous recombination typically occurs at low frequency in ES cells, requiring sophisticated selection schemes and screening of hundreds of clones to identify the desired mutant; (ii) large (15–20 kb) plasmids, often difficult to clone, are required to increase targeting efficiency and (iii) breeding mice to homozygosity and housing a mouse colony generate further delays and costs.
low frequency
0.264706
easy
3CIS7GGG65JS8I3AZ9RG54AE4N6EU8
biomed
BMP family members are now known to play an extremely diverse set of roles in a wide variety of developmental processes [4].
diverse set
0.264706
easy
39I4RL8QGJH5BU0XA484D39XXQAH44
biomed
To facilitate the functional analysis of the ACDP gene family, we cloned and characterized Acdp, the mouse homologue of the human ACDP gene family.
functional analysis
0.266667
easy
3FI30CQHVKJ9Z41PT0RNOQQDY4B6BY
biomed
Moreover, the observed transcriptional shift in ETS signaling is paired with the onset of appropriate regulation of neuronal subtype specification and establishment of axonal projections into the target area.
target area
0.266667
easy
36MUZ9VAE626RGSODE1RV46QINBEDY
biomed
A plausible model is that Dmrt7 evolved during the establishment of mammalian sex determination to help cope with ancestral differences in gene dosage, chromosome pairing, recombination, or other meiotic issues arising from sex chromosome heteromorphy.
sex determination
0.266667
easy
3KI0JD2ZU1IMXSYZGJF7JO4HFEK67C
biomed
The switch that controls sex determination is biologically diverse.
sex determination
0.296875
easy
3V8JSVE8YYQ9PRNF9AO58PGR0BHEY6
biomed
In these two spontaneous mutants [1] and in the Itpr1-deficient mouse [4] generated by gene targeting, decreased Itpr1 expression is associated with the same autosomal recessive movement disorder (Figure 1).
movement disorder
0.275
easy
3EGKVCRQFWSBIOBVZJMF7HA6XE4BY3
biomed
DNA repair enzymes repair the frequent damage to DNA caused by oxidant stress as well as other stresses, including bulky adducts derived from carcinogens in cigarette smoke [8].
frequent damage
0.276316
easy
36U4VBVNQODHHM8FLFBG4B9XJCVUR0
biomed
Based on these data, Crx was hypothesized to play a critical role in the differentiation and maintainance of photoreceptor cells [5,7].
critical role
0.276316
easy
3VGZ74AYTGGU62I1JDW4B19KA3ECGD
biomed
These results demonstrate important epistatic interactions between genes from 129 and C57BL/6 genomes on the development of autoimmunity and illustrate the important effects of background genes in the analysis and interpretation of autoimmune phenotypes associated with targeted genetic disruptions.
important effects
0.277778
easy
3OQQD2WO8I6KPTSDG8L63AI6J3TI3D
biomed
The homozygous mice for the conditional allele are viable and indistinguishable to the normal mice, allowing us to study the roles of Apc in a tissue- and temporal-specific manner.
normal mice
0.279412
easy
3N7PQ0KLI5P89OQRKPVFIVKERAM3EP
biomed
However, some susceptibility loci have been mapped to similar chromosome locations in different strains, suggesting that at least some susceptibility may be shared amongst lupus-prone strains.
different strains
0.279412
easy
3LN3BXKGC0V3K0O604W5NVGN2JWWG6
biomed
All of these findings raise many questions as to the possible role(s) of alpha-crystallin in the nucleus and in cell cycle regulation during differentiation.
many questions
0.279412
easy
3D4BBDG7ZHWTCQ6DOYPKS7KB6Y9C35
biomed
MCAD-deficient patients have abnormal plasma and urine metabolites associated with the medium chain–length enzyme specificity.
medium chain
0.279412
easy
3BFNCI9LYKQN09BHXHH9CLSX5NI373
biomed
Many of these dimorphisms affect somatic cells, but the sexual dimorphisms that most directly mediate sexual reproduction are those of the gametes themselves.
sexual reproduction
0.279412
easy
3BDORL6HKKDLVSRFZOQGA5NRCCPRCO
biomed
In the adult spinal cord, while motor neurons express high levels of NT-3, other cells, including glia, also express it (Zhou and Rush 1994; Dreyfus et al. 1999; Buck et al. 2000).
high levels
0.28125
easy
3CMV9YRYP31X08284WA6BXRNW49LJ6
biomed
The same mechanism seems to apply in vivo with Aqp2F204V/+ mice.
same mechanism
0.283333
easy
3W0KKJIARR9XWLO7SS1E775URTA8K6
biomed
We have employed the same approach to analyse the genetic basis of disease inheritance in the (129 × C57BL/6) hybrid strain, the most common genetic background in gene-targeted mice.
same approach
0.283333
easy
3VW0145YLYCH6QKT48BLBA6CW9ZJM6
biomed
The new information of the current work includes: 1).
new information
0.283333
easy
3538U0YQ1FU0F2QNF0FL0D5E3B13F7
biomed
Abnormal lysosomal storage bodies and large vacuoles have been found in skin and conjuctival biopsies using electron-microscopy and, prior to gene identification, served as the only means of diagnosis [3-5].
only means
0.285714
easy
3NCN4N1H1GHH6P7HSHD4Q1CZTU0BND
biomed
Mice with or without intact dopamine D2R-mediated signaling displayed similar decreases in latencies to retrieve unhidden food pellets (Fig. 1) and learned to dig for food buried in unscented sand (Fig. 2).
unscented sand
0.2875
easy
3Y40HMYLL1I1EIURUEH8TTVLKTGUXW
biomed
Mutations in either Gdf5 or the closely related Gdf6 gene also block formation of joints at specific locations, providing strong evidence that these molecules are essential for the joint formation process (Storm et al. 1994; Settle et al. 2003).
specific locations
0.289474
easy
3CESM1J3EI31N7Z0ORNJB43Y85T6WE
biomed
This conclusion is consistent with the finding that severely reduced levels of huntingtin, from a hypomorphic Hdh allele, lead to abnormal brains later in embryonic development [15].
embryonic development
0.289474
easy
3VI0PC2ZAYK61DAUYS5ZUN3W27TOXE
biomed
Although a mechanistic understanding of why a deficiency in cholesterol biosynthesis leads to abnormal embryonic development is lacking, a frequently advanced explanation has been that Shh signaling, involved in early developmental patterning, may be disrupted.
embryonic development
0.475
neutral
3UL5XDRDNCJUE234L5X85IMCU3F85L
biomed
These findings represent a novel role for T-box gene action in embryonic development and provide evidence for a previously unappreciated complexity to acquisition of dorsoventral positional identity in mammalian skin.
embryonic development
0.6
difficult
3R15W654VDTEMV6LZMUF8Y39AZ1QL2
biomed
Recent studies with floxed alleles suggest that Bmpr1a is also required for many later developmental events, but its roles in bone and joint formation have not yet been tested (Mishina 2003).
joint formation
0.294118
easy
3R16PJFTS3RWDK15GPB1QVPPP7DK4A
biomed
In addition, levels of Bmpr1a mRNA and protein may persist for some time following Gdf5-Cre stimulated recombination, making it possible to bypass an early requirement for Bmpr1a in joint formation at some locations.
joint formation
0.45
neutral
31MCUE39BKM6T2MIQKL3IY5Q4Q1G3J
biomed
At some sites, loss of Bmpr1a function leads to a defect in the early stages of joint formation, resulting in a complete failure to form a joint and fusion of bones in the ankle.
joint formation
0.470588
neutral
3P6ENY9P79WZJ1ZCVTA874JG28BIHK
biomed
EFW assisted in the production of the AlphaA/BKO mice, experimental design, and initial fixation of samples.
experimental design
0.294118
easy
3FI30CQHVKJ9Z41PT0RNOQQDY4BB63
biomed
Second, in an independent study, Powell was able to compare derivatives of CAPAN-1 that differed only in their ability to express full-length BRCA2 protein (S. Powell, personal communication, 2001).
personal communication
0.296875
easy
3VDI8GSXAFTSUZSO21GZ9FD1KCTG8B
biomed
Currently it is held that excitatory dopamine D1Rs mediate the acquisition and expression of several conditioned behaviors involving food reinforcers [e.g. [6,7]] as well as responding for conditioned cues predictive of cocaine delivery [9] – consistent with the interpretation that D1R mediated signaling might modulate the maintenance of stimulus-response outcomes.
cocaine delivery
0.296875
easy
3LG268AV3860SQBTVFWB0TNUXO2ER4
biomed
One of the most curious findings in the rd7 mutant retina was the occurrence of two different types of changes: an increase in the number of S-opsin–expressing cones and a transformation of rods into hybrid photoreceptors.
curious findings
0.3
easy
3I6NF2WGIGW97H9M439WXV3AIMS5GY
biomed
Although over-expression of calpastatin, the endogenous protein inhibitor of μ- and m-calpain provides an important approach for these efforts, it will not distinguish isoform specific functions [24,26,27].
important approach
0.3
easy
3KTCJ4SCVG1AB94PEJ5F7AAQ2S01ML
biomed
Although advances in the medical management of pulmonary hypoplasia may have decreased the mortality associated with CDH patients who survive to receive care at high-volume centers [2,3], the population-based mortality has been reported to be as great as 62%, and there are a large number of deaths prior to birth or to transfer to a tertiary care facility [4].
medical management
0.3
easy
3MZ3TAMYTLNC8VDFRYM2L8LMPH9IRH
biomed
Alpha-crystallin may play a functional role in the cell nucleus and may have a role in regulating the cell cycle.
functional role
0.3
easy
3MNJFORX8B43THDRTJ3EFA3YH7S5FZ
biomed
For each, there has to be a question as to whether the anti-nuclear autoimmunity is due to the gene-targeted mutant gene or to the normal 129 genes expressed in the same region as the targeted gene.
same region
0.302632
easy
3909MD9T2ZH3P06K4KWHJ49BU0REF9
biomed
The testis and ovary represent two divergent pathways of development from the bipotential embryonic gonad.
divergent pathways
0.303571
easy
3B9J25CZ25DXW7RSEDQL0FSNYE8CSX
biomed
The vesicle formation goes along with several other changes in the red blood cell like cytoskeletal rearrangements and changes in the phospholipid orientation in the cellular membrane.
blood cell
0.305556
easy
3J9L0X0VDFMO5Q1YMYQVVEU0Y61W9F
biomed
These data suggest the basis for the performance deficit on the rotating rod task in the Syt IV mutants is in motor coordination rather than in motor learning.
motor learning
0.305556
easy