id stringlengths 30 30 | corpus stringclasses 3 values | sentence stringlengths 22 724 | token stringlengths 8 29 | complexity float64 0.03 0.98 | difficulty stringclasses 5 values |
|---|---|---|---|---|---|
31ODACBENUF1Q81BJVRGKKH42T9QSG | biomed | These studies might clarify whether ADAM11 plays an important signalling or structural role at the synaptic level and whether it participates in synaptic regulation. | important signalling | 0.45 | neutral |
37J05LC5AXJE2WEGRFCISKJINV7JDO | biomed | We therefore wished to investigate the feasibility of non-invasive multiple reporter imaging in mice, and as a first step we wanted to ascertain whether we could establish viable and fertile mice with widespread expression of GFP variant reporters. | reporter imaging | 0.45 | neutral |
3X878VYTIEIIGLRAHCIBDUHU8DNF7O | biomed | Loss of functional Dhcr7 led to a retardation of embryonic growth from E14.5~E16.5 onwards. | embryonic growth | 0.45 | neutral |
3J6BHNX0U9SIZSBBYUQXP4VPGO9NK9 | biomed | The first gene downstream of Sry known to show male-specific up-regulation in Sertoli cell precursors is a related gene expressed in many tissues in the developing embryo , Sox9. | related gene | 0.452381 | neutral |
3P458N04Q1HSU6LPBU72NA0T12X2XM | biomed | Since the parental strains differ in susceptibility to CIA, in spite of both having the MHC class II A beta genes [15], we wanted to test the susceptibility to inflammatory disease in mice from this cross. | parental strains | 0.453125 | neutral |
3VMHWJRYHVGCV0X1ZPM97TUIA62FXJ | biomed | We have investigated the embryonic processes that require huntingtin in order to more precisely delineate huntingtin's essential molecular and cellular activities and to provide clues to the mechanism by which the dominant polyglutamine expansion mutation in huntingtin leads to HD pathogenesis. | cellular activities | 0.453125 | neutral |
338GLSUI43B4ZJB25FGM8LDQVR0FSB | biomed | Moreover, mutant embryos contained only eight to 16 cells at the E4 stage, instead of 32 cells observed for wild-type or heterozygous blastocysts (Figure 1C and 1D). | mutant embryos | 0.453125 | neutral |
3YD0MU1NC21NKUA26WWJZT63BXAA76 | biomed | These include the serum proteins β2-glycoprotein 1 and protein S [20,21], the growth-arrest-specific gene product GAS-6 [22], complement activation products [23], the milk fat globule protein MFG-E8 [24], and annexin I [25]. | protein S | 0.453125 | neutral |
3PA41K45VN4U7YG4VFEGPOVYAJA7PJ | biomed | Besides their lack of receptor subtype specificity, an acute exposure to commercially available D2 receptor antagonists fails to completely block signaling mediated solely by D2Rs. | subtype specificity | 0.453125 | neutral |
3G9UA71JVVUYLND6029WSS9M1K47JJ | biomed | While D2R antagonists have been used in the context of rodent associative learning paradigms, their lack of receptor subtype specificity [13] and motor-disrupting effects [6,8] have prevented a rigorous examination of the actual role this dopamine receptor subtype plays in associative and reversal learning in the context of an operant behavior. | subtype specificity | 0.546875 | neutral |
3R5OYNIC2C9H5WDB8IHHUKNGZG1TPH | biomed | Significantly, the reports cited above failed to address the technical limitations of the approach: i.e. that the antagonists used lack adequate subtype specificity and only partially blocked D2R-mediated signaling thus making it impossible to rigorously assess the role of D2R-mediated signaling in associative and reversal learning. | subtype specificity | 0.631579 | difficult |
3UYRNV2KITZY4R9AP5TUZZMYLOF8NB | biomed | Since the possible new locus of potential interest on chromosome 1 was of suggestive significance, and since the locus identified on chromosome 13 probably is Cia28, we are now paying special attention to the significant QTL for CIA incidence detected at 60–70 cM on chromosome 11 (denoted Cia40). | CIA incidence | 0.455882 | neutral |
3GMLHYZ0LEXQENK1ZA3AC72UMZBYU7 | biomed | This means that this region contains genes affecting the CIA incidence in multiparous mice in addition to the rate of successful deliveries in female mice. | CIA incidence | 0.541667 | neutral |
3W31J70BASWZ8OEK94HJ9T1DHKVCKG | biomed | Crx-/- photoreceptors demonstrate a complete block in outer segment formation at the elongation stage. | segment formation | 0.455882 | neutral |
3R6RZGK0XFCQR29140DF8T4D06KYVW | biomed | However, the possibility that primary pulmonary developmental abnormalities occur with, rather than secondary to, diaphragmatic defects has been suggested by others based on a teratogenic model of CDH [49–51] and has long been suspected by clinicians who care for these patients. | developmental abnormalities | 0.458333 | neutral |
3YLPJ8OXX8D2XK0CF8QQGPXRLGT4XK | biomed | Precocious initiation of ETS signaling in post-mitotic DRG neurons leads to abnormal DRG neuron differentiation characterized by neurotrophin-independent neurite outgrowth and inappropriate profiles of gene expression. | neuron differentiation | 0.460526 | neutral |
3R868ACW4SC7EVTBBRGCMZA5JL0GZG | biomed | These two ETS proteins control late aspects of spinal monosynaptic circuit assembly, with Er81 directing proprioceptive sensory neuron differentiation and Pea3 directing motor neuron pool differentiation, respectively [14,15]. | neuron differentiation | 0.558824 | neutral |
378G7J1SJLY50MSFU96HNSVBP3HEW7 | biomed | To analyze the physiological roles of ESG1, we identified the mouse gene on chromosome 9 and deleted it by homologous recombination in ES cells. | mouse gene | 0.4625 | neutral |
3XDJY5RK5SLAGG6HA3F3WIYNRYC4US | biomed | Thus the same transcription factor apparently serves as an activator or repressor, depending on the target gene. | transcription factor | 0.4625 | neutral |
3W9XHF7WGKVGU5GVVQC9Y31H56VTKG | biomed | In XX gonads or XY mutant gonads lacking Sry, Sox9, or Fgf9, the SOX9/FGF9 feed-forward loop is not established, and WNT4 gains control of the gonadal field. | gains control | 0.464286 | neutral |
3SSN80MU8CONBMPF00D6N6MNI2JKXQ | biomed | Homozygous Cln3Δex7/8 knock-in mice exhibit a progressive JNCL-like disease, with perinatal onset of subunit c deposition in many cell types and later onset of neuronal dysfunction and behavioral deficits [12]. | behavioral deficits | 0.466667 | neutral |
30Z7M1Q8UYKRK8FLG1OPDT2YMHGA8T | biomed | BRCA2 was the second breast cancer susceptibility gene to be discovered, and was isolated through positional cloning using data from families with inherited breast cancer [4]. | susceptibility gene | 0.46875 | neutral |
33NKDW9FFXI5SODR8NW8ZN9FDTACX5 | biomed | Experimental validation shows that some, but not all, predictions are accurate [24,25]. | Experimental validation | 0.46875 | neutral |
37SOB9Z0SSXMFU0J1BIJVQAY07N3LC | biomed | However, it has been noted that deletion of the Fc receptor (the primary receptor for microglial opsinization of antibody–antigen complexes) in APP transgenic mouse models has no impact on the effectiveness of antibody-mediated therapy [56,57]. | primary receptor | 0.470588 | neutral |
3Z3R5YC0P3N5EJOHUFLCIQ9CXAETFE | biomed | BRCA2 may thus promote RAD51 assembly into recombinational repair complexes via a negative regulatory mechanism (i.e. by blocking RAD51-BRCA2 interaction until damage has occurred and factors required for 'productive' assembly of RAD51 at damaged sites are in place). | regulatory mechanism | 0.472222 | neutral |
3XH7ZM9YX2UJXUKCN4GP8FMJ6RMR97 | biomed | Thus, during the evolution of vertebrates, subsequent successive duplications of the ancestral gene cluster have given rise to three TACC family members located close to FGFR genes in humans. | successive duplications | 0.473684 | neutral |
38G0E1M85M59ATPWUZGQ58Y04I8UVT | biomed | Crx, a downstream target of Otx2, controls the transcription of various photoreceptor cell-specific genes and is essential for the formation of outer segments, synaptic terminals, and phototransduction pathways [8,10]. | synaptic terminals | 0.475 | neutral |
3LN50BUKPVBTMJ56Z9FQ8TDZ53FPLA | biomed | However, the targeted transcriptional factors directly responsible for reprogramming the fiber-specific contractile and metabolic genes remain to be identified. | metabolic genes | 0.475 | neutral |
366FYU4PTGPE5MYY5VNEZH1G2W8EKB | biomed | In addition, pendrin expression has been found in the kidney [9], mammary gland [10], uterus [11], testes [12] and placenta [13]. | mammary gland | 0.475 | neutral |
375VMB7D4JJI7LUA9XRIGJ4IAGIDI6 | biomed | Our results showed that cholesterol deficiency, caused by loss of Dhcr7 activity, did not alter lung branching morphogenesis (early gestational stages, E9.5 to E14.5). | gestational stages | 0.47619 | neutral |
3JGHED38EDROGC85M2AZ2FOAEOD7YD | biomed | This study provides evidence that the late onset of transcription factor expression is essential for many later aspects of neuronal differentiation and circuit formation. | factor expression | 0.482143 | neutral |
3BO3NEOQM0HK9ERYPN0GQIWCPDLAI1 | biomed | Interestingly, the majority of the intervals detected are strain-specific, confirming the genetic complexity of the disease and indicating the presence of extensive heterogeneity in the genes contributing to the pathogenesis of the disease. | genetic complexity | 0.483333 | neutral |
3QTFNPMJC6IDONAXYVT7CJJ2KXMNZV | biomed | Consistent with the filter trap results presented above, there were no significant differences in SDS- or FA-soluble Aβ between the 6 mo untreated cohort and either the 6 mo + 3 mo treated or 6 mo + 6 mo treated cohorts. | untreated cohort | 0.484375 | neutral |
32CXT5U14G3BZHTJM65GDUESTK8U8P | biomed | In contrast, the extent of amyloid pathology in mice from the 6 mo + 3 mo treated or 6 mo + 6 mo treated cohorts closely resembled that of the 6 mo untreated cohort, despite the significant age difference between the treated and untreated groups (Figures 4 and Figure S3). | untreated cohort | 0.5 | neutral |
3YLTXLH3DF6R0NMG8O0SG1KSOM6PH3 | biomed | Northern blot and immunohistochemistry analysis show the expression of Annexin A7 in all embryonic tissues from day E5 on, the earliest day studied. | embryonic tissues | 0.485294 | neutral |
3SSN80MU8CONBMPF00D6N6MNI2IXK2 | biomed | Heterozygous knockouts were normal and had normal levels of BCAA despite having approximately half of BCKDH enzymatic activity. | enzymatic activity | 0.485294 | neutral |
38XPGNCKHT0ATVVHFTP8S40655KV47 | biomed | It was also demonstrated that mutations leading to abolishment of the enzymatic activity of CLN2 were the direct cause of a fatal inherited neurodegenerative disease, classical late-infantile neuronal ceroid lipofuscinosis [2]. | enzymatic activity | 0.625 | difficult |
3RWO3EJELH9GWC126ZX7OE4L7XB1PH | biomed | In order to generate a DsRed variant that may be amenable to use in ES cells and mice, we recently introduced various sequences that direct nuclear localization to the DsRed coding region. | coding region | 0.485294 | neutral |
3JYPJ2TAYI87MRVADYCSDG8F87TFPV | biomed | These results, together with the altered pattern of gene expression seen in our Bmpr1a-deficient mice, suggest that BMPR1A signaling may normally act to stimulate SOX9 by post-translational protein modification, or to induce L-Sox5 or Sox6 in cartilage to maintain expression of ECM components. | protein modification | 0.485294 | neutral |
3MWOYZD5WVO1PJWQWMIQWLCY0TJNOT | biomed | Nevertheless it might interact with other components and have a role in organizing the membrane cytoskeleton, controlling raft protein associations or influencing the ionic strength of red blood cells on its own or by interfering with other signaling pathways. | ionic strength | 0.485294 | neutral |
3IZPORCT1F9CC02VLG4HLWK7P4URHX | biomed | In conclusion, we have found that sensitivity to the bitter-tasting substance quinine, as assayed by a taste specific brief-access test, is a polygenic trait in mice. | polygenic trait | 0.486111 | neutral |
3MIVREZQVHY32PO3EMIETYQULZWQKZ | biomed | We have investigated the embryonic processes that require huntingtin in order to more precisely delineate huntingtin's essential molecular and cellular activities and to provide clues to the mechanism by which the dominant polyglutamine expansion mutation in huntingtin leads to HD pathogenesis. | embryonic processes | 0.5 | neutral |
371DNNCG442WZ4EUM1F68YSQA61T8X | biomed | Glutathione efficiently complexes cadmium (78) and scavenges free radicals and other reactive oxygen species directly, and indirectly via enzymatic reactions (45). | free radicals | 0.5 | neutral |
3P4C70TRMRHN96C7WQP3EKZ74CSLG2 | biomed | A fourth gene involved in glucose metabolism, glucokinase regulatory protein (Gckr), was found to be increased in three out of three microarrays at P21 but was not tested by in situ hybridization (Table S4). | fourth gene | 0.5 | neutral |
3VMV5CHJZ8FBSJKC5ZRU0B9OYPEGT0 | biomed | Although these genetic studies now implicate the need for normal cholesterol synthesis, the mechanistic role(s) of cholesterol in normal embryonic development remains to be clarified. | cholesterol synthesis | 0.5 | neutral |
3421H3BM9AH2Z61ZFZ7G6O0SWASJ97 | biomed | The unique 86 amino acid c-terminal tail lacks the lysosomal targeting signal and does not contain any conserved domains when compared against the current profile databases. | targeting signal | 0.5 | neutral |
3BPP3MA3TCKPPSGGQVZFEHEVRWDLEL | biomed | The failure to maintain articular cartilage in the absence of normal BMPR1A function suggests that ligands or small molecule agonists that interact specifically with this receptor subtype may be particularly good candidates for designing new approaches to maintain or heal articular cartilage at postnatal stages. | receptor subtype | 0.5 | neutral |
3TZDZ3Y0JS6V4PLVPA1A2O462TS91T | biomed | Although individual genes code for each dopamine receptor subtype, there is considerable pharmacological overlap between D1-like and D2-like receptors. | receptor subtype | 0.59375 | neutral |
36KM3FWE3RCRJHCKEUZQANUQ2BY075 | biomed | One further point worthy of note is the striking similarity between the hybrid photoreceptor identified in this study and a naturally occurring photoreceptor found in ground squirrels. | striking similarity | 0.5 | neutral |
36GJS3V78VQHEGO7T5DQY5MF0NNJGY | biomed | Expression has been found in the inner ear and thyroid gland consistent with the clinical signs of deafness and goiter [2,3,8]. | thyroid gland | 0.5 | neutral |
3GS542CVJVNUS7MEQX3M5EHNE9X95B | biomed | A discontinuity of this complex junction in Slc26a4-/- mice would explain the absence of the endocochlear potential. | complex junction | 0.5 | neutral |
3NZ1E5QA6Z1DG01BOHHIWKCD2905BH | biomed | While several transcriptional regulatory proteins have been associated with cell fate determination of bone marrow mesenchymal cells, including peroxisome proliferator–activated receptor γ (PPARγ) and KLF5 [25–30], the role of RNA binding proteins in this process remains unknown. | regulatory proteins | 0.5 | neutral |
3BDORL6HKKDLVSRFZOQGA5NRCCPCR9 | biomed | BCKDH is also associated with two regulatory proteins, a specific kinase and a phosphatase which regulate the activity of this enzyme through a phosphorylation (inactivation) and dephosphorylation (activation) cycle of the E1 α subunit [5,6]. | regulatory proteins | 0.55 | neutral |
3LN3BXKGC0V3K0O604W5NVGN2JWGWQ | biomed | Using this approach, several studies have independently shown that the NC-specific deletion of the Tgfbr2 gene leads to a distinct set of calvarial, facial and cardiac defects [8,9,20,29]. | distinct set | 0.5 | neutral |
35O6H0UNLSGJYJZNC9UZU8VQAE95J2 | biomed | Traditionally, congenic strains are developed by introgressing QTL alleles from a donor strain, whose boundaries are defined by genetic markers, on the genetic background of a recipient strain via 10 backcrosses [4]. | donor strain | 0.5 | neutral |
3DTJ4WT8BDF9UHXK5WQOMWPT65LEZX | biomed | The long term retention of afferents in the cochlear apex in the absence of any apparent differentiation of hair cells raises hopes for cochlear implants in deaf-born children. | term retention | 0.5 | neutral |
3UDTAB6HH6ZVX00DTRXAOJLWX1M90Q | biomed | The findings of Caohuy et al. [37] that annexin A7 mediates membrane aggregation also suggested that annexin A7 is an essential component during vesiculation. | membrane aggregation | 0.5 | neutral |
3FVBZG9CLJEOC6IWR3L210JKGEUH0O | biomed | Thus, our observations provide unexpected starting-points in the search for huntingtin's precise molecular activities, which began with the discovery that this HEAT domain protein hosts the dominant polyglutamine property that is the fundamental basis of HD pathogenesis. | fundamental basis | 0.5 | neutral |
3KQC8JMJGCSKTYHTAQ3L3YHRJQEH3J | biomed | Subsequently, CNS apoptosis was shown to be an indirect result of placental defects and probable hypoxia [12–14]. | placental defects | 0.5 | neutral |
3O71U79SRBPA5T3JR2KZ3BXZSSCMSP | biomed | ET, NM, MI, TO and KY contributed to the generation of knockout mice. | knockout mice | 0.5 | neutral |
33KGGVH24UHL5L3TSQ7OIRQO9WK1X5 | biomed | Our data indicate that DRG neurons undergo a temporal change in their competence to respond to ETS transcription factor signaling, as assessed by changes in gene expression and axonal target invasion (Figure 9). | factor signaling | 0.5 | neutral |
3D0LPO3EABZV1I043OR1D1A54DNYOU | biomed | From the characterization studies completed thus far, the null mutation mouse accurately represents a model of classic MSUD and appears to be a faithful model of the human disease with respect to several biochemical phenotypes [1]. | mutation mouse | 0.5 | neutral |
32TMVRKDGNYCIJZ470EY0QGYU7L48D | biomed | For example, in a previous study, we carried out a genome screen to identify the quantitative trait loci (QTL) in collagen-induced arthritis (CIA), which is a widely used animal model of RA. | genome screen | 0.5 | neutral |
34ZTTGSNJXOC0ZNV81FHG6A2TISHQM | biomed | Based upon classical N-glycosylation maturation it would appear that Abcg5/sterolin-1, in the Abcg8-/- mice, does not exit the endoplasmic reticulum. | endoplasmic reticulum | 0.513158 | neutral |
3MYASTQBG7BVOJITM5WRPLV41QZDQ9 | biomed | Itpr1 is coupled to Ca2+ channels and facilitates Ca2+ release from the endoplasmic reticulum after binding by the intracellular second messenger inositol 1,4,5-triphosphate [9]. | endoplasmic reticulum | 0.733333 | difficult |
3M7OI89LVYOS99TV70NIZAWVGPBC6B | biomed | Moreover, the ablation of GluR-B, but also changes in the extent of Q/R site editing of GluR-B, can alter the strength of excitatory synaptic transmission in the genetically addressed neuronal populations [51,58,60], thus potentially shifting the balance of excitatory and inhibitory transmission in the affected circuits. | neuronal populations | 0.513889 | neutral |
309D674SHZLYFLAQ3R4QAQINUQMCBW | biomed | Transgenic expression of APPswe/ind and consequent overproduction of Aβ42 cause early-onset amyloid deposition in untreated mice, in which deposits appear as early as 2 mo of age. | consequent overproduction | 0.514706 | neutral |
3BAKUKE49HC18PHHJR1WT9408FYR1Y | biomed | Indirect support for this idea is provided by the observation that Fabp7 is up-regulated by microarray analysis in Nrl and Crx mutant retinas as well (unpublished data), suggesting that this change may represent a generalized response to injury in the retina rather than derepression of a cone-enriched gene. | mutant retinas | 0.515625 | neutral |
38B7Q9C28G5QBBMSVGDRXKVNA4896R | biomed | Indeed, organogenesis generally proceeded without detectable abnormality, with few exceptions. | detectable abnormality | 0.515625 | neutral |
3DIIW4IV8PV57PBHGMQPDFACX3PI4Y | biomed | However, computational prediction of the location of 5' upstream exons and the extent of the 3' UTR from genomic sequence has been extremely difficult. | computational prediction | 0.515625 | neutral |
3OEWW2KGQJBS375D7S4N0G04MPHDO1 | biomed | We biochemically measured the amount of aggregated Aβ in the brains of our mice before and after transgene suppression using filter trap analysis of cortical tissue from each animal. | cortical tissue | 0.52381 | neutral |
3XWUWJ18TLQ9XE0WP96L9MWHQBZUU4 | biomed | Altogether, our findings suggest a role for NT-3 in initiation of muscle innervation and spindle differentiation by the proprioceptive axons. | spindle differentiation | 0.525 | neutral |
3WRKFXQBOB7L5WP15TEWT4EJS4OIYJ | biomed | However, no defects in axon pathfinding along the monosynaptic reflex arc or in muscle spindle differentiation have been noted in PV KO mice, which develop normally and show no apparent changes in their behavior or physical activity (Schwaller et al. 1999). | spindle differentiation | 0.785714 | difficult |
3SCKNODZ0XGU4D4RF01OLZQ3A48N72 | biomed | In these instances, only a few null embryos are ever observed and homozygous mutant ES cells could not be isolated. | null embryos | 0.525 | neutral |
31KPKEKW4ADELTFARBB6FPGML1P0BR | biomed | This impairment may also explain the failure of huntingtin deficient embryos to properly restrict the expression of Fgf8, Nodal and Gsc. | deficient embryos | 0.525 | neutral |
3IZPORCT1F9CC02VLG4HLWK7P4UHRN | biomed | Based on the theory that Sertoli cells initiate all downstream testicular differentiation, this might imply that Sertoli differentiation had been initiated in Wnt4 −/− XX gonads. | testicular differentiation | 0.526316 | neutral |
3WJGKMRWVI9RUI8AHNVW5G6NXBYCD3 | biomed | In the case of Csrp1, expression analyses and DNA-binding studies indicate that MTF-1 is required for cadmium induction by binding to an MRE upstream of the transcription start. | cadmium induction | 0.526316 | neutral |
385MDVINFCFDB2E78AH8K883UBDJWX | biomed | To test the hypothesis that a temporal delay in the onset of transcriptional programs is crucial for the control of appropriate neuronal maturation, we studied the development of proprioceptive DRG neurons, since transcriptional effectors regulated by target-derived signals, as well as some of their downstream biological actions, have been identified for these neurons. | neuronal maturation | 0.526316 | neutral |
3BPP3MA3TCKPPSGGQVZFEHEVRWDELE | biomed | The involvement of target-derived signals in induction of ETS transcription factor expression raises the question of the necessity for the observed delay in the onset of ETS signaling for neuronal maturation. | neuronal maturation | 0.546875 | neutral |
3XDSWAMB22SLJRCFM91G5FDMGQNQCM | biomed | Our findings reveal that target-triggered inductive signals provide an effective means of ensuring the late onset of expression of transcription factors, and thus an orderly temporal transcriptional sequence that is crucial for neuronal maturation and circuit assembly. | neuronal maturation | 0.588235 | neutral |
3QI9WAYOGQB8GQIR4MDIEF0D2SX6SZ | biomed | First, these genes are evolutionarily conserved in many phylogenetically divergent species; Second, multiple genes are present in a species; Third, these genes are ubiquitously expressed throughout development and adult tissues (unpublished data). | divergent species | 0.527778 | neutral |
38DCH97KHH28R5ILW1I2SJQH6AWQJ0 | biomed | LCAD−/− mice show more spontaneous deaths and gestational losses than the other deficiencies [21]. | gestational losses | 0.527778 | neutral |
3XH7ZM9YX2UJXUKCN4GP8FMJ6RM9RP | biomed | However, our findings indicate that the coactivator PGC-1α serves a critical role in the normal metabolic function of multiple organs and for appropriate adaptation to physiologic stress during postnatal life. | appropriate adaptation | 0.527778 | neutral |
3UUIU9GZC55DCMVSO383WEIZ8G05T7 | biomed | Positional cloning analysis identified Fog2 (Zfpm2) as a likely candidate, and DNA sequencing revealed a mutation in a splice donor site that generates an abnormal transcript encoding a truncated protein. | abnormal transcript | 0.529412 | neutral |
391JB9X4ZY8CHAQBMTBXCP6PBYZKM6 | biomed | Marginal cells appeared to form a continuous layer. | Marginal cells | 0.529412 | neutral |
3OYHVNTV5TY0HDBNZ9QA4TVU6YEKOL | biomed | This transgene expresses cre very early in limb development, resulting in complete recombination of floxed alleles at early limb bud stages. | complete recombination | 0.529412 | neutral |
3XU80RHWHZGBZIC2VXOLJE0TSLP446 | biomed | In the rodent retina, the production of specific cell types during development progresses in a general order [1,2]. | rodent retina | 0.529412 | neutral |
3PMR2DOWOO1TV1G2927VO667SHK45B | biomed | Data from a number of previous studies also show that different olfactory receptor genes, or even copies of the same olfactory receptor transgene in different genomic locations are expressed in different numbers of cells [14,18,35], but do not address the issue of transcript level per cell. | genomic locations | 0.529412 | neutral |
3TKXBROM5TAVA7U2JTDTJHZVF0FIJP | biomed | Similar conclusions may apply to other gene-targeted animals carrying mutations of genes mapped in the 129-derived susceptibility allele on Chromosome 7 (O'Keefe et al. 1996, 1999). | susceptibility allele | 0.529412 | neutral |
3P7RGTLO6EDBF9HMPQLS3YBPHHAKAM | biomed | These data also demonstrate that genome-wide SNP assay can facilitate rapid detection of structural genomic mutations that may underlie disease. | genomic mutations | 0.529412 | neutral |
33CLA8O0MIBSY4BPQQGHIB8U9PHFRN | biomed | To protect themselves from free radical damage, intermediate cells generate glutathione and melanin pigment [34-37]. | melanin pigment | 0.53125 | neutral |
3NSCTNUR2ZN8XQWJI3HM19S7KRFA5R | biomed | Both PGC-1α-deficient lines exhibit cold intolerance, reduced hepatocyte respiration rates, and neurologic lesions. | neurologic lesions | 0.53125 | neutral |
38RHULDV9YFHGRU1QSW887T3HWOIWK | biomed | This subset of pluripotent neural crest stem cells forms in the dorsal aspect of the neural tube at the level of the mid-otic placode to the third somite [1]. | neural tube | 0.53125 | neutral |
3B286OTISEHG4PB475LG2JBC2SAAJD | biomed | It is not likely that merely the concentration of these components explains the increased rebleeding time and reduced arterial occlusion time in the A/J mice. | occlusion time | 0.533333 | neutral |
3LOJFQ4BOXF9DGKY90CUTZJV2K7DKH | biomed | The genes may interact with components in the Plg network and modulate arterial occlusion time. | occlusion time | 0.642857 | difficult |
3T8DUCXY0N6WD9X4RTLK8UN1UCJT9M | biomed | The defining feature of all PAX proteins is the presence of a 128 amino acid DNA-binding paired domain that has been highly conserved over evolution [1]. | paired domain | 0.533333 | neutral |
3RDTX9JRTY19FB0XEQIJ3YVJ5FS97Q | biomed | In addition, we could not detect full-length or smaller PGC-1α proteins by Western blotting. | Western blotting | 0.533333 | neutral |
3Q9SPIIRWJM2A9B3E44VR95K4OJAW8 | biomed | Olfactory receptors were originally identified in an elegant experiment based on the hypothesis that they would be seven-transmembrane-domain proteins encoded by a large, diverse gene family whose expression is restricted to the olfactory epithelium [3]. | Olfactory receptors | 0.535714 | neutral |
3X7837UUADYFHNZ1HS44ME9Q69K6JJ | biomed | Polymorphisms and mutations in coagulation factors, fibrinolytic factors, platelet surface receptors, methylenetetrahydrofalate reductase, endothelial nitric oxide synthase, and antioxidant enzymes have been implicated as genetic determinants of susceptibility to thrombosis [6,7]. | antioxidant enzymes | 0.535714 | neutral |
3EFNPKWBMSO9IYBXCIW0X6IAX9C030 | biomed | Finally, RanBP2 appears to join other nucleoporins, such as Nup96 [58], in novel physiological functions that are vital for complex organisms and that were not anticipated from cell-based studies. | physiological functions | 0.539474 | neutral |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.