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Shades and Tints of #e18558 |
A shade is achieved by adding black to any pure hue, while a tint is created by mixing white to any pure color. In this example, #100703 is the darkest color, while #fffefe is the lightest one. |
Shade Color Variation |
Tint Color Variation |
Tones of #e18558 |
A tone is produced by adding gray to any pure hue. In this case, #9d9c9c is the less saturated color, while #f87d41 is the most saturated one. |
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Color Blindness Simulator |
Below, you can see how #e18558 is perceived by people affected by a color vision deficiency. This can be useful if you need to ensure your color combinations are accessible to color-blind users. |
• #9b9b9b Achromatopsia 0.005% of the population |
• #a9978e Atypical Achromatopsia 0.001% of the population |
• #afa168 Protanopia 1% of men |
• #c49a5c Deuteranopia 1% of men |
• #e5858e Tritanopia 0.001% of the population |
• #c19762 Protanomaly 1% of men, 0.01% of women |
• #ce925a Deuteranomaly 6% of men, 0.4% of women |
• #e4857a Tritanomaly 0.01% of the population |
Australian Prime Minister Turnbull gets US backing |
By Nick Beams |
24 September 2015 |
The Obama administration has endorsed Malcolm Turnbull as Australian prime minister, seeking to quell concerns that he might pursue a different orientation towards the US anti-China “pivot to Asia” because of his emphasis on the importance of the world’s second largest economy for Australian business. |
The endorsement came in the form of comments by the US ambassador to Australia, John Berry, reported today by Sydney Morning Herald journalist John Garnaut in an article headlined “US envoy: Malcolm Turnbull is our man.” |
According to the report, Berry said Washington had “enormous confidence in the continuity of Australia’s military and intelligence policies” under Turnbull. |
“It’s a story of rock-solid bipartisan support, on both sides of the Pacific, continuing from Abbott to Turnbull,” Berry said in an interview with the newspaper. “I only see hope, I don’t see any fear, and when I talk to everybody in Washington they’re all in absolute agreement.” |
Questions have been raised that Turnbull might pursue a different tack in relation to the pivot because of his previous comments. In a speech following Obama’s official launching of the pivot from the floor of the Australian parliament in November 2011, Turnbull warned that Australia had to be careful not to allow a “d... |
Last January, however, in a major speech in the US as moves were beginning against former Prime Minister Tony Abbott, Turnbull pointedly emphasised the importance of the US pivot, signalling to Washington there would not be a foreign policy shift were he to become leader. At the same time, he has sought to strengthen t... |
In his interview, Berry sought to deflect criticisms that Turnbull’s new security team was inexperienced and might shift towards China at the expense of the United States. |
“We categorically reject this false binary choice. We’re not asking Australia to make a choice,” he said, adding that China was Australia’s largest export market and America’s third-largest economic partner. |
Some of the criticism of the cabinet has been directed to the relatively unknown New South Wales Liberal Senator Marise Payne as Australia’s first female defence minister. But Berry made clear the US was very supportive. |
“We think Marise Payne is a very bold and innovative choice. People know her, they trust her, she is a careful person, she is a person of judgment, and so our side is glad to see this highly professional person with unquestioned integrity and critical skills in this field,” he said. |
Such a ringing endorsement indicates that while her public profile may have been low to this point, Payne is well known in military circles, both in Australia and the US. |
In comments last Tuesday, which were noted by the Wall Street Journal, Payne made clear the continuing support for the US pivot or “rebalance” as the Pentagon refers to it. She said her first priority in her new post would be to meet US Defence Secretary Ashton Carter, Secretary of State John Kerry and that she and Tur... |
“That I hope reinforces for anyone who may have had an alternative view, that that is a key meeting for this government and for Prime Minister Malcolm Turnbull of where we intend to take [foreign relations],” she said. |
On Monday night, in his first major interview on the ABC’s program “7.30,” in response to a question on global security, Turnbull quickly turned to China’s disputes with neighbouring countries and its construction of facilities on shoals in the South China Sea. |
He said it was important to ensure that the rise of China, which was not going to stop, is “conducted in a manner that does not disturb the security and relative harmony of the region upon which China’s prosperity depends.” |
So far Turnbull has not expressed the view that China is an aggressive and expansionist power. But at the same time, he has made clear that he endorses the US pivot. In order to do that he criticised Chinese moves in the region as “counter-productive” to its own longer-term objectives. |
“Pushing the envelope in the South China Sea has had the consequences of exactly the reverse … of what China would seek to achieve,” he told “7.30.” “You would think that what China would seek to achieve is to create a sufficient feeling of trust and confidence among its neighbours that they no longer felt the need to ... |
In fact, Turnbull’s presentation of events stands the situation on its head. It is not Chinese moves in the region, which have provoked the pivot but the reverse. With the coming to power of the Obama administration in 2009, following a decade of rapid Chinese growth—averaging more than 10 percent a year—the US recogni... |
Unable to respond economically, especially in the wake of the American-centred global financial crisis, the US has sought to redress the balance militarily. This led to the pivot to Asia which is underpinned by a military build-up against China. As part of this strategy, the US intervened directly in the long-running b... |
Turnbull’s presentation of the situation is a historical falsification. But it serves a definite political purpose. It enables his government to support the US pivot and its stepped up military pressure, on the one hand while keeping aloof from the branding of China as aggressive on the other. Instead, Turnbull poses h... |
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Could dormancy allow Lyme disease to survive antibiotics? |
“Dormancy is a protective state where diverse bacteria including M. tuberculosis, S. aureus, T. pallidum (syphilis), and B. burgdorferi (Lyme Disease) curtail metabolic activity to survive external stresses including antibiotics,” states Mali from the University of Houston in the Journal Bacteriology. [1] |
by Daniel J. Cameron, MD MPH |
Feng and colleagues from Johns Hopkins University have identified FDA-approved drugs that might work on in vitro B. burgdorferi persisters. [2] |
Persistence may be a subset of dormancy. “Evidence suggests dormancy consists of a continuum of interrelated states including viable but nonculturable (VBNC) and persistence states,” according to Mali. “VBNC and persistence contribute to antibiotic tolerance, reemergence from latent infections, and even quorum sensing ... |
Mali’s definition of persister and VBNC cells offers an insight into dormancy: |
• “Persister cells have been identified as a “small subpopulation of cells that spontaneously enter a dormant, nondividing state,” a definition based on survival after antibiotic treatment of bacterial cell populations. |
• VBNC are “living cells that have lost the ability to grow on routine media.” |
Mali does acknowledge the difficulties differentiating and isolating VBNC and persister cells, pointing out that “both states exhibit enhanced survival under antibiotic treatment.” Persister and VBNC cells may coexist and contribute to reduced metabolic activity, antibiotic tolerance, latent infection, and reemergence ... |
The authors point out the difference between persister and VBNC as a starting point for discussion: |
• “We propose to describe persister cells as proliferation-competent cells that can spontaneously resuscitate after resolution of stress.” |
• “VBNC cells are induced into a non-proliferative state by external stress and will not resuscitate spontaneously until an appropriate external signal is provided.” |
The authors’ work could lead to identification of proteins that drive the dormant state. |
1. Mali S, Mitchell M, Havis S, Bodunrin A, Rangel J, Olson G, Widger WR, Bark SJ. A Proteomic Signature of Dormancy in an Actinobacterium: Micrococcus luteus. J Bacteriol. 2017 May 8. pii: JB.00206-17. doi: 10.1128/JB.00206-17. |
2. Feng J, Auwaerter PG, Zhang Y. Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline. PLoS One. 2015;10(3):e0117207. |
3 Replies to "Could dormancy allow Lyme disease to survive antibiotics?" |
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Good Samaritans |
But a certain Samaritan who was traveling that way came upon him, and when he saw him, his heart was filled with pity.” (Luke 10:33). Provide acts of love and kindness toward those who suffer tragedy or sudden loss – those in need of helping hands as they recover and heal. |
Susan Brady |
The aim of this ministry is to offer immediate and supporting care for families that have experienced sudden loss of spouse or home due to accident, weather, fire or violence. |
By its nature, this is an ad hoc ministry that takes shape when and as circumstances demand. |
• Establish and maintain list of people who the Parish can rely for any number of charitable outreach tasks. For example preparing a meal, mowing a lawn, running an errand, etc. (the list is endless). |
• Institute procedures for parish office to alert the ministry in the event of a request for aid. |
Whether you own, represent, or work for multiple companies, you can have or be part of more than one karma account at any given time. |
You can use a single email address to connect all of the accounts to one login, but the data from each account will be completely separate. |
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Rodney Branigan |
'..the discovery of the year or even the decade,' Crossroads Magazine |
Ever seen someone play 2 guitars at once? Rodney Branigan can play two better than most can play one! US born Rodney Branigan relocated to the UK after learning his craft across the pond and has since been stunning audiences around the world with his jaw dropping guitar skills and delightful song writing ability. |
Having toured the world several times, including support slots for respected performers such as Jack Johnson, Billy Bragg, G-Love and Show of Hands Branigan proves that he's top of his craft and never fails to please an audience with his passionate performances. BBC Cambridge referred to Branigan as l 'Living Legend' a... |
Cornucopia for the Senses |
Imagine it. Boat rigging clanking in the river breeze as ships pull in from long sea journeys, filled with goods to sell. Men shout as they move over the river docks and levees like ants, unloading heavy cargo ready for the stalls. The river laps against the wooden sides of the moored ships. Wagons rattle and horses... |
As you made your way up from the river and into the market itself, you’d encounter all types of humanity. Native Americans, the remnants of once great tribes such as the Choctow, sit selling their herbs alongside Italian fruit merchants and men coming downriver from the interior. Stalls are covered by palmetto fronds ... |
Screen Shot 2017-06-18 at 5.24.34 PM |
Old French Market circa 1920 (photo courtesy of New Orleans Public Library) |
And the smells. Sounds in the air would have competed with all kinds of odors – spices, rotting fruit, horse dung, baking bread, roasting nuts, fresh meat – like a cornucopia to the senses as you moved your way through rows of stalls. Like the bazaars of old, the French Market enticed and offended in equal measure. It... |
Sitting on the same spot since 1791, the French Market in New Orleans was born much earlier as an Indian trading post alongside the Mississippi River. It was the Spanish who first enclosed the market to protect the delicate fruits and vegetables from the elements of subtropic New Orleans. This first enclosed market w... |
fullsizeoutput_1dc7The market would evolve and transform as the city changed hands from Spanish to French to American. As the market evolved, wild game, seafood, and fowl began appearing in the food stalls. The French Market evolved into a crossroads where civilization and wilderness met. Not only could you find item... |
The structure itself would expand, contract, and rebuild again and again over the centuries as hurricanes, war, and sickness affected the port city. Over time and out of necessity, improvements were made. Walls were shored up by brick and then covered over by plaster to resemble stone. Awnings were no longer temporar... |
John James Audubon once came to the market to purchase freshly killed birds to use as models for his paintings. He found it “…the dirtiest place in all the Cities of the United States.” Over the centuries, this contaminated environment allowed sickness to rise out of the sullied stalls like a fog rising from the near... |
Similarly in times of war, both in the War of 1812 and the Civil War, New Orleans was a hot commodity due to her perch at the mouth of the Mississippi. Soldiers came and went, but the market was an ever constant reality, both in times peace and war. |
fullsizeoutput_cf2fullsizeoutput_191cfullsizeoutput_1312Today, as you make your way around the market, you are greeted by boutiques and tourist shops selling all matter of t-shirts, mardi gras beads, and hurricane glasses. Despite that, in some corners, you can still sense that dark, decaying underbelly of the New Orle... |
If you can time it right, come early in the morning and stroll the old aisles before the crowds and heat descend. This is the time of day when merchants hose down their stalls to prepare for the coming crowds. As the water sprays in the sunshine and falls to the pavement, grab a café au lait and a freshly powdered, bu... |
You can’t get much closer to the past. |
All photos by the author except where otherwise indicated. |
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Constrained Deterministic Leader-Follower Mean Field Control |
Lukas Möller, Basilio Gentile, Francesca Parise, Sergio Grammatico, John Lygeros |
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