context stringlengths 124 10.1k | question stringlengths 18 189 | id stringlengths 28 28 | answers dict |
|---|---|---|---|
Influence of terminal differentiation and PACAP on the cytokine, chemokine, and growth factor secretion of mammary epithelial cells. Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide with trophic and cytoprotective effects, has been shown to affect cell survival, proliferation, and also differe... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_001 | {
"answer_start": [
1222
],
"text": [
"epidermal growth factor"
]
} |
Influence of terminal differentiation and PACAP on the cytokine, chemokine, and growth factor secretion of mammary epithelial cells. Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide with trophic and cytoprotective effects, has been shown to affect cell survival, proliferation, and also differe... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_002 | {
"answer_start": [
1279
],
"text": [
"epidermal growth factor"
]
} |
Influence of terminal differentiation and PACAP on the cytokine, chemokine, and growth factor secretion of mammary epithelial cells. Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide with trophic and cytoprotective effects, has been shown to affect cell survival, proliferation, and also differe... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_003 | {
"answer_start": [
1313
],
"text": [
"amphiregulin"
]
} |
Distinct effects of EGFR ligands on human mammary epithelial cell differentiation. Based on gene expression patterns, breast cancers can be divided into subtypes that closely resemble various developmental stages of normal mammary epithelial cells (MECs). Thus, understanding molecular mechanisms of MEC development is e... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_004 | {
"answer_start": [
1236
],
"text": [
"epidermal growth factor"
]
} |
Distinct effects of EGFR ligands on human mammary epithelial cell differentiation. Based on gene expression patterns, breast cancers can be divided into subtypes that closely resemble various developmental stages of normal mammary epithelial cells (MECs). Thus, understanding molecular mechanisms of MEC development is e... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_005 | {
"answer_start": [
1267
],
"text": [
"amphiregulin"
]
} |
Ligand-dependent activation of EGFR in follicular dendritic cells sarcoma is sustained by local production of cognate ligands. PURPOSE: The aim of this study was to investigate the biological and clinical significance of epidermal growth factor receptor (EGFR) signaling pathway in follicular dendritic cell sarcoma (FDC... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_006 | {
"answer_start": [
1100
],
"text": [
"Betacellulin"
]
} |
EGFR ligands as pharmacodynamic biomarkers in metastatic colorectal cancer patients treated with cetuximab and irinotecan. This study was conducted to describe the modulation of plasma epidermal growth factor receptor (EGFR) ligands in EGFR-positive metastatic colorectal cancer (mCRC) patients during treatment with cet... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_007 | {
"answer_start": [
473
],
"text": [
"epidermal growth factor"
]
} |
EGFR ligands as pharmacodynamic biomarkers in metastatic colorectal cancer patients treated with cetuximab and irinotecan. This study was conducted to describe the modulation of plasma epidermal growth factor receptor (EGFR) ligands in EGFR-positive metastatic colorectal cancer (mCRC) patients during treatment with cet... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_008 | {
"answer_start": [
504
],
"text": [
"transforming growth factor-α"
]
} |
EGFR ligands as pharmacodynamic biomarkers in metastatic colorectal cancer patients treated with cetuximab and irinotecan. This study was conducted to describe the modulation of plasma epidermal growth factor receptor (EGFR) ligands in EGFR-positive metastatic colorectal cancer (mCRC) patients during treatment with cet... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_009 | {
"answer_start": [
454
],
"text": [
"amphiregulin"
]
} |
Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor. UNLABELLED: Intrahepatic cholangiocarcinoma (CCA) is characterized by an abundant desmoplastic environment. Poor prognosis of CCA has been associated with the presence of alpha-smooth muscl... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_010 | {
"answer_start": [
513
],
"text": [
"epidermal growth factor"
]
} |
Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor. UNLABELLED: Intrahepatic cholangiocarcinoma (CCA) is characterized by an abundant desmoplastic environment. Poor prognosis of CCA has been associated with the presence of alpha-smooth muscl... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_011 | {
"answer_start": [
497
],
"text": [
"heparin-binding epidermal growth factor"
]
} |
Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. Aberrant epidermal growth factor receptor (EGFR) expression promotes the pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), the most common malignancy ass... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_012 | {
"answer_start": [
962
],
"text": [
"betacellulin"
]
} |
Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. Aberrant epidermal growth factor receptor (EGFR) expression promotes the pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), the most common malignancy ass... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_013 | {
"answer_start": [
976
],
"text": [
"epiregulin"
]
} |
Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. Aberrant epidermal growth factor receptor (EGFR) expression promotes the pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), the most common malignancy ass... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_014 | {
"answer_start": [
1009
],
"text": [
"transforming growth factor-α"
]
} |
Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. Aberrant epidermal growth factor receptor (EGFR) expression promotes the pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), the most common malignancy ass... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_015 | {
"answer_start": [
1047
],
"text": [
"amphiregulin"
]
} |
Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. Aberrant epidermal growth factor receptor (EGFR) expression promotes the pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), the most common malignancy ass... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_016 | {
"answer_start": [
1065
],
"text": [
"epigen"
]
} |
Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling. Prolidase, also known as Xaa-Pro dipeptidase or peptidase D (PEPD), is a ubiquitously expressed cytosolic enzyme that hydrolyzes dipeptides with proline or hydroxyproline at the carboxyl terminus. In this articl... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_017 | {
"answer_start": [
389
],
"text": [
"epidermal growth factor"
]
} |
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Epidermal growth factor (EGF) family peptides are ligands for the EGF receptor (EGFR). Here, we elucidate functional differences among EGFR ligands and mechanisms underlying these distinctions. In 32D/EGFR myeloid and MCF10A bre... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_018 | {
"answer_start": [
92
],
"text": [
"Epidermal growth factor"
]
} |
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Epidermal growth factor (EGF) family peptides are ligands for the EGF receptor (EGFR). Here, we elucidate functional differences among EGFR ligands and mechanisms underlying these distinctions. In 32D/EGFR myeloid and MCF10A bre... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_019 | {
"answer_start": [
514
],
"text": [
"betacellulin"
]
} |
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Epidermal growth factor (EGF) family peptides are ligands for the EGF receptor (EGFR). Here, we elucidate functional differences among EGFR ligands and mechanisms underlying these distinctions. In 32D/EGFR myeloid and MCF10A bre... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_020 | {
"answer_start": [
572
],
"text": [
"epiregulin"
]
} |
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Epidermal growth factor (EGF) family peptides are ligands for the EGF receptor (EGFR). Here, we elucidate functional differences among EGFR ligands and mechanisms underlying these distinctions. In 32D/EGFR myeloid and MCF10A bre... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_021 | {
"answer_start": [
339
],
"text": [
"amphiregulin"
]
} |
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Epidermal growth factor (EGF) family peptides are ligands for the EGF receptor (EGFR). Here, we elucidate functional differences among EGFR ligands and mechanisms underlying these distinctions. In 32D/EGFR myeloid and MCF10A bre... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_022 | {
"answer_start": [
422
],
"text": [
"epigen"
]
} |
Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells. Asthma is a chronic inflammatory disease that is associated with airway remodeling, including hyperplasia of airway epithelial cells and airway smooth muscle cells, and goblet cell differe... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_023 | {
"answer_start": [
613
],
"text": [
"epidermal growth factor"
]
} |
Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells. Asthma is a chronic inflammatory disease that is associated with airway remodeling, including hyperplasia of airway epithelial cells and airway smooth muscle cells, and goblet cell differe... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_024 | {
"answer_start": [
597
],
"text": [
"heparin-binding epidermal growth factor"
]
} |
Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells. Asthma is a chronic inflammatory disease that is associated with airway remodeling, including hyperplasia of airway epithelial cells and airway smooth muscle cells, and goblet cell differe... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_025 | {
"answer_start": [
580
],
"text": [
"amphiregulin"
]
} |
Amphiregulin exosomes increase cancer cell invasion. Autocrine, paracrine, and juxtacrine are recognized modes of action for mammalian EGFR ligands including EGF, TGF-α (TGFα), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin, epiregulin, and epigen. We identify a new mode of EGFR liga... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_026 | {
"answer_start": [
247
],
"text": [
"betacellulin"
]
} |
Amphiregulin exosomes increase cancer cell invasion. Autocrine, paracrine, and juxtacrine are recognized modes of action for mammalian EGFR ligands including EGF, TGF-α (TGFα), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin, epiregulin, and epigen. We identify a new mode of EGFR liga... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_027 | {
"answer_start": [
261
],
"text": [
"epiregulin"
]
} |
Amphiregulin exosomes increase cancer cell invasion. Autocrine, paracrine, and juxtacrine are recognized modes of action for mammalian EGFR ligands including EGF, TGF-α (TGFα), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin, epiregulin, and epigen. We identify a new mode of EGFR liga... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_028 | {
"answer_start": [
177
],
"text": [
"amphiregulin"
]
} |
Amphiregulin exosomes increase cancer cell invasion. Autocrine, paracrine, and juxtacrine are recognized modes of action for mammalian EGFR ligands including EGF, TGF-α (TGFα), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin, epiregulin, and epigen. We identify a new mode of EGFR liga... | List signaling molecules (ligands) that interact with the receptor EGFR? | 55046d5ff8aee20f27000007_029 | {
"answer_start": [
277
],
"text": [
"epigen"
]
} |
Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly du... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_001 | {
"answer_start": [
1198
],
"text": [
"miR-100"
]
} |
Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly du... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_002 | {
"answer_start": [
1466
],
"text": [
"miR-100"
]
} |
Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly du... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_003 | {
"answer_start": [
1207
],
"text": [
"miR-141"
]
} |
Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly du... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_004 | {
"answer_start": [
1343
],
"text": [
"miR-141"
]
} |
Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly du... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_005 | {
"answer_start": [
1188
],
"text": [
"miR-200a"
]
} |
Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly du... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_006 | {
"answer_start": [
1309
],
"text": [
"MiR-200a"
]
} |
Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly du... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_007 | {
"answer_start": [
1216
],
"text": [
"miR-200b"
]
} |
Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly du... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_008 | {
"answer_start": [
1319
],
"text": [
"miR-200b"
]
} |
Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly du... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_009 | {
"answer_start": [
1230
],
"text": [
"miR-200c"
]
} |
Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly du... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_010 | {
"answer_start": [
1329
],
"text": [
"miR-200c"
]
} |
Upregulation of microRNA-203 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer. MicroRNA-203 (miR-203), possessing tumor suppressive or promotive activities, has been found to be downregulated or upregulated in different cancer types. The purpose of this study was to investig... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_011 | {
"answer_start": [
1208
],
"text": [
"miR-203"
]
} |
Upregulation of microRNA-203 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer. MicroRNA-203 (miR-203), possessing tumor suppressive or promotive activities, has been found to be downregulated or upregulated in different cancer types. The purpose of this study was to investig... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_012 | {
"answer_start": [
1411
],
"text": [
"miR-203"
]
} |
The biphasic expression pattern of miR-200a and E-cadherin in epithelial ovarian cancer and its correlation with clinicopathological features. Epithelial ovarian cancer (EOC) is the leading cause of death among gynecologic malignancies. Despite great efforts to improve early detection and optimize chemotherapeutic regi... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_013 | {
"answer_start": [
784
],
"text": [
"miR-200a"
]
} |
The biphasic expression pattern of miR-200a and E-cadherin in epithelial ovarian cancer and its correlation with clinicopathological features. Epithelial ovarian cancer (EOC) is the leading cause of death among gynecologic malignancies. Despite great efforts to improve early detection and optimize chemotherapeutic regi... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_014 | {
"answer_start": [
1522
],
"text": [
"miR-200a"
]
} |
The biphasic expression pattern of miR-200a and E-cadherin in epithelial ovarian cancer and its correlation with clinicopathological features. Epithelial ovarian cancer (EOC) is the leading cause of death among gynecologic malignancies. Despite great efforts to improve early detection and optimize chemotherapeutic regi... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_015 | {
"answer_start": [
1601
],
"text": [
"miR-200a"
]
} |
The biphasic expression pattern of miR-200a and E-cadherin in epithelial ovarian cancer and its correlation with clinicopathological features. Epithelial ovarian cancer (EOC) is the leading cause of death among gynecologic malignancies. Despite great efforts to improve early detection and optimize chemotherapeutic regi... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_016 | {
"answer_start": [
1683
],
"text": [
"miR-200a"
]
} |
MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. One of the best prognostic predictors for patients with epithelial ovarian cancer is the Federation of Obstetrics and Gynecology (FIGO) stage at diagnosis. Advanced-stage ovarian serous carcinoma (OSC) generally have poor p... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_017 | {
"answer_start": [
1539
],
"text": [
"miR-509-5p"
]
} |
MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. One of the best prognostic predictors for patients with epithelial ovarian cancer is the Federation of Obstetrics and Gynecology (FIGO) stage at diagnosis. Advanced-stage ovarian serous carcinoma (OSC) generally have poor p... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_018 | {
"answer_start": [
1777
],
"text": [
"miR-509-5p"
]
} |
MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. One of the best prognostic predictors for patients with epithelial ovarian cancer is the Federation of Obstetrics and Gynecology (FIGO) stage at diagnosis. Advanced-stage ovarian serous carcinoma (OSC) generally have poor p... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_019 | {
"answer_start": [
1515
],
"text": [
"miR-510"
]
} |
MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. One of the best prognostic predictors for patients with epithelial ovarian cancer is the Federation of Obstetrics and Gynecology (FIGO) stage at diagnosis. Advanced-stage ovarian serous carcinoma (OSC) generally have poor p... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_020 | {
"answer_start": [
1765
],
"text": [
"miR-510"
]
} |
MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. One of the best prognostic predictors for patients with epithelial ovarian cancer is the Federation of Obstetrics and Gynecology (FIGO) stage at diagnosis. Advanced-stage ovarian serous carcinoma (OSC) generally have poor p... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_021 | {
"answer_start": [
1296
],
"text": [
"miR-509-5p"
]
} |
MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. One of the best prognostic predictors for patients with epithelial ovarian cancer is the Federation of Obstetrics and Gynecology (FIGO) stage at diagnosis. Advanced-stage ovarian serous carcinoma (OSC) generally have poor p... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_022 | {
"answer_start": [
1287
],
"text": [
"miR-510"
]
} |
Identification of serum microRNA-21 as a biomarker for early detection and prognosis in human epithelial ovarian cancer. Recent investigations have confirmed up-regulation of serum miR-21 and its diagnostic and prognostic value in several human malignancies. In this study, we examined serum miR-21 levels in epithelial ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_023 | {
"answer_start": [
292
],
"text": [
"miR-21"
]
} |
Identification of serum microRNA-21 as a biomarker for early detection and prognosis in human epithelial ovarian cancer. Recent investigations have confirmed up-regulation of serum miR-21 and its diagnostic and prognostic value in several human malignancies. In this study, we examined serum miR-21 levels in epithelial ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_024 | {
"answer_start": [
474
],
"text": [
"miR-21"
]
} |
Identification of serum microRNA-21 as a biomarker for early detection and prognosis in human epithelial ovarian cancer. Recent investigations have confirmed up-regulation of serum miR-21 and its diagnostic and prognostic value in several human malignancies. In this study, we examined serum miR-21 levels in epithelial ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_025 | {
"answer_start": [
559
],
"text": [
"miR-21"
]
} |
Identification of serum microRNA-21 as a biomarker for early detection and prognosis in human epithelial ovarian cancer. Recent investigations have confirmed up-regulation of serum miR-21 and its diagnostic and prognostic value in several human malignancies. In this study, we examined serum miR-21 levels in epithelial ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_026 | {
"answer_start": [
703
],
"text": [
"miR-21"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_027 | {
"answer_start": [
1818
],
"text": [
"let-7b"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_028 | {
"answer_start": [
1809
],
"text": [
"miR-26a"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_029 | {
"answer_start": [
1800
],
"text": [
"miR-132"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_030 | {
"answer_start": [
1830
],
"text": [
"miR-145"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_031 | {
"answer_start": [
1450
],
"text": [
"let-7b"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_032 | {
"answer_start": [
1649
],
"text": [
"let-7b"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_033 | {
"answer_start": [
1441
],
"text": [
"miR-26a"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_034 | {
"answer_start": [
1640
],
"text": [
"miR-26a"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_035 | {
"answer_start": [
1432
],
"text": [
"miR-132"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_036 | {
"answer_start": [
1631
],
"text": [
"miR-132"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_037 | {
"answer_start": [
1458
],
"text": [
"miR-145"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_038 | {
"answer_start": [
1661
],
"text": [
"miR-145"
]
} |
Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer. BACKGROUND: There is a critical need for improved diagnostic markers for high grade serous epithelial ovarian cancer (SEOC). MicroRNAs are stable in the circulation and may have utility as biomarkers of malignanc... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_039 | {
"answer_start": [
868
],
"text": [
"miR-200a"
]
} |
Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer. BACKGROUND: There is a critical need for improved diagnostic markers for high grade serous epithelial ovarian cancer (SEOC). MicroRNAs are stable in the circulation and may have utility as biomarkers of malignanc... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_040 | {
"answer_start": [
878
],
"text": [
"miR-200b"
]
} |
Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer. BACKGROUND: There is a critical need for improved diagnostic markers for high grade serous epithelial ovarian cancer (SEOC). MicroRNAs are stable in the circulation and may have utility as biomarkers of malignanc... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_041 | {
"answer_start": [
891
],
"text": [
"miR-200c"
]
} |
MicroRNA let-7a: a potential marker for selection of paclitaxel in ovarian cancer management. OBJECTIVES: Let-7 is a family of small non-coding RNAs regulating the expression of many genes that control important cellular activities. Let-7 is shown in vitro to sensitize cancer cells to platinum, but induce ovarian cance... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_042 | {
"answer_start": [
9
],
"text": [
"let-7a"
]
} |
MicroRNA let-7a: a potential marker for selection of paclitaxel in ovarian cancer management. OBJECTIVES: Let-7 is a family of small non-coding RNAs regulating the expression of many genes that control important cellular activities. Let-7 is shown in vitro to sensitize cancer cells to platinum, but induce ovarian cance... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_043 | {
"answer_start": [
2203
],
"text": [
"let-7a"
]
} |
MicroRNA let-7a: a potential marker for selection of paclitaxel in ovarian cancer management. OBJECTIVES: Let-7 is a family of small non-coding RNAs regulating the expression of many genes that control important cellular activities. Let-7 is shown in vitro to sensitize cancer cells to platinum, but induce ovarian cance... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_044 | {
"answer_start": [
2242
],
"text": [
"let-7a"
]
} |
Association between miR-200c and the survival of patients with stage I epithelial ovarian cancer: a retrospective study of two independent tumour tissue collections. BACKGROUND: International Federation of Gynecology and Obstetrics stage I epithelial ovarian cancer (EOC) has a significantly better prognosis than stage ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_045 | {
"answer_start": [
2739
],
"text": [
"miR-200c"
]
} |
MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer. MicroRNAs (miRNA) are approximately 22-nucleotide noncoding RNAs that negatively regulate protein-coding gene expression in a sequence-specific manner via translational inhibition or mRNA degradation. O... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_046 | {
"answer_start": [
31
],
"text": [
"Let-7i"
]
} |
MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer. MicroRNAs (miRNA) are approximately 22-nucleotide noncoding RNAs that negatively regulate protein-coding gene expression in a sequence-specific manner via translational inhibition or mRNA degradation. O... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_047 | {
"answer_start": [
1660
],
"text": [
"let-7i"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_048 | {
"answer_start": [
1818
],
"text": [
"let-7b"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_049 | {
"answer_start": [
1809
],
"text": [
"miR-26a"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_050 | {
"answer_start": [
1800
],
"text": [
"miR-132"
]
} |
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients. OBJECTIVE: MicroRNA (miRNA) is an abundant class of small noncoding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression ... | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | 553fa78b1d53b76422000007_051 | {
"answer_start": [
1830
],
"text": [
"miR-145"
]
} |
History central to diagnosing myasthenia gravis. Myasthenia gravis (MG) is caused by failure of chemical transmission at the neuromuscular junction. It is an autoimmune disorder in which antibodies interfere with neuromuscular transmission. It has a prevalence of around 20 per 100,000. The incidence is bimodal with a 2... | Which acetylcholinesterase inhibitors are used for treatment of myasthenia gravis? | 5149199dd24251bc05000040_001 | {
"answer_start": [
1300
],
"text": [
"Pyridostigmine"
]
} |
Benefits from sustained-release pyridostigmine bromide in myasthenia gravis: results of a prospective multicenter open-label trial. INTRODUCTION: For more than 50 years the acetylcholinesterase inhibitor pyridostigmine bromide has been the drug of choice in the symptomatic therapy for myasthenia gravis. The sustained-r... | Which acetylcholinesterase inhibitors are used for treatment of myasthenia gravis? | 5149199dd24251bc05000040_002 | {
"answer_start": [
204
],
"text": [
"pyridostigmine"
]
} |
Treatment of myasthenia gravis: focus on pyridostigmine. Acquired myasthenia gravis (MG) is a chronic autoimmune disorder of the neuromuscular junction, characterized clinically by muscle weakness and abnormal fatigability on exertion. Current guidelines and recommendations for MG treatment are based largely on clinica... | Which acetylcholinesterase inhibitors are used for treatment of myasthenia gravis? | 5149199dd24251bc05000040_003 | {
"answer_start": [
613
],
"text": [
"pyridostigmine"
]
} |
Treatment of myasthenia gravis: focus on pyridostigmine. Acquired myasthenia gravis (MG) is a chronic autoimmune disorder of the neuromuscular junction, characterized clinically by muscle weakness and abnormal fatigability on exertion. Current guidelines and recommendations for MG treatment are based largely on clinica... | Which acetylcholinesterase inhibitors are used for treatment of myasthenia gravis? | 5149199dd24251bc05000040_004 | {
"answer_start": [
737
],
"text": [
"pyridostigmine"
]
} |
Acetylcholinesterase inhibitor treatment for myasthenia gravis. BACKGROUND: In myasthenia gravis, antibody-mediated blockade of acetylcholine receptors at the neuromuscular junction abolishes the naturally occurring 'safety factor' of synaptic transmission. Acetylcholinesterase inhibitors provide temporary symptomatic ... | Which acetylcholinesterase inhibitors are used for treatment of myasthenia gravis? | 5149199dd24251bc05000040_005 | {
"answer_start": [
2596
],
"text": [
"neostigmine"
]
} |
Treatment of myasthenia gravis: focus on pyridostigmine. Acquired myasthenia gravis (MG) is a chronic autoimmune disorder of the neuromuscular junction, characterized clinically by muscle weakness and abnormal fatigability on exertion. Current guidelines and recommendations for MG treatment are based largely on clinica... | Which acetylcholinesterase inhibitors are used for treatment of myasthenia gravis? | 5149199dd24251bc05000040_006 | {
"answer_start": [
825
],
"text": [
"Pyridostigmine"
]
} |
Expression of dishevelled gene in Hirschsprung's disease. UNLABELLED: Hirschsprung's disease (HSCR) is a congenital disorder of the enteric nervous system and is characterized by an absence of enteric ganglion cells in terminal regions of the gut during development. Dishevelled (DVL) protein is a cytoplasmic protein wh... | List the human genes encoding for the dishevelled proteins? | 5709e4b2cf1c32585100001c_001 | {
"answer_start": [
448
],
"text": [
"DVL-1"
]
} |
Expression of dishevelled gene in Hirschsprung's disease. UNLABELLED: Hirschsprung's disease (HSCR) is a congenital disorder of the enteric nervous system and is characterized by an absence of enteric ganglion cells in terminal regions of the gut during development. Dishevelled (DVL) protein is a cytoplasmic protein wh... | List the human genes encoding for the dishevelled proteins? | 5709e4b2cf1c32585100001c_002 | {
"answer_start": [
458
],
"text": [
"DVL-3"
]
} |
cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. The Drosophila dishevelled gene (dsh) encodes a secreted glycoprotein, which regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast... | List the human genes encoding for the dishevelled proteins? | 5709e4b2cf1c32585100001c_003 | {
"answer_start": [
444
],
"text": [
"DVL-1"
]
} |
cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. The Drosophila dishevelled gene (dsh) encodes a secreted glycoprotein, which regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast... | List the human genes encoding for the dishevelled proteins? | 5709e4b2cf1c32585100001c_004 | {
"answer_start": [
454
],
"text": [
"DVL-3"
]
} |
Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. In the Drosophila embryo dishevelled (dsh) function is required by target cells in order to respond to wingless (wg, the homolog of Wnt-1), demonstrating a role for dsh in Wnt signal transduction. We have isolated a m... | List the human genes encoding for the dishevelled proteins? | 5709e4b2cf1c32585100001c_005 | {
"answer_start": [
444
],
"text": [
"Dvl-1"
]
} |
Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma. The Dvl-1 gene on chromosome 1p36 belongs to a family of highly conserved secreted proteins which regulates embryonic induction, generation of cell polarity and specification of cell... | List the human genes encoding for the dishevelled proteins? | 5709e4b2cf1c32585100001c_006 | {
"answer_start": [
142
],
"text": [
"Dvl-1"
]
} |
Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma. The Dvl-1 gene on chromosome 1p36 belongs to a family of highly conserved secreted proteins which regulates embryonic induction, generation of cell polarity and specification of cell... | List the human genes encoding for the dishevelled proteins? | 5709e4b2cf1c32585100001c_007 | {
"answer_start": [
414
],
"text": [
"DVL-1"
]
} |
Wnt-mediated relocalization of dishevelled proteins. The Wnt family of proto-oncogenes encodes secreted signaling proteins that are required for mouse development. The Drosophila Wnt homolog, the wingless (Wg) segment polarity gene, mediates a signal transduction pathway in which the downstream elements appear to be co... | List the human genes encoding for the dishevelled proteins? | 5709e4b2cf1c32585100001c_008 | {
"answer_start": [
551
],
"text": [
"Dvl-1"
]
} |
Notch receptor expression in adult human liver: a possible role in bile duct formation and hepatic neovascularization. Notch signaling is an evolutionarily conserved mechanism, used to regulate cell fate decisions. Four Notch receptors have been identified in man (Notch-1 to -4). In this study, semiquantitative reverse... | Which are the different isoforms of the mammalian Notch receptor? | 55072c803b8a5dc045000001_001 | {
"answer_start": [
265
],
"text": [
"Notch-1"
]
} |
Notch receptor expression in adult human liver: a possible role in bile duct formation and hepatic neovascularization. Notch signaling is an evolutionarily conserved mechanism, used to regulate cell fate decisions. Four Notch receptors have been identified in man (Notch-1 to -4). In this study, semiquantitative reverse... | Which are the different isoforms of the mammalian Notch receptor? | 55072c803b8a5dc045000001_002 | {
"answer_start": [
628
],
"text": [
"Notch-1"
]
} |
Notch receptor expression in adult human liver: a possible role in bile duct formation and hepatic neovascularization. Notch signaling is an evolutionarily conserved mechanism, used to regulate cell fate decisions. Four Notch receptors have been identified in man (Notch-1 to -4). In this study, semiquantitative reverse... | Which are the different isoforms of the mammalian Notch receptor? | 55072c803b8a5dc045000001_003 | {
"answer_start": [
713
],
"text": [
"Notch-3"
]
} |
Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations. Cellular senescence is recognized as a critical cellular response to prolonged rounds of replication and environmental stresses. Its defining characteristics are arrested cell-cycle progression and the development of aberrant gen... | Which are the major characteristics of cellular senescence? | 53061af558348c0f52000002_001 | {
"answer_start": [
253
],
"text": [
"arrested cell-cycle progression"
]
} |
Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations. Cellular senescence is recognized as a critical cellular response to prolonged rounds of replication and environmental stresses. Its defining characteristics are arrested cell-cycle progression and the development of aberrant gen... | Which are the major characteristics of cellular senescence? | 53061af558348c0f52000002_002 | {
"answer_start": [
293
],
"text": [
"development of aberrant gene expression with proinflammatory behavior"
]
} |
Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Although reactive oxygen species have been proposed to play a major role in the aging process, the exact molecular mechanisms remain elusive. ... | Which are the major characteristics of cellular senescence? | 53061af558348c0f52000002_003 | {
"answer_start": [
814
],
"text": [
"altered morphology"
]
} |
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