context stringlengths 124 10.1k | question stringlengths 18 189 | id stringlengths 28 28 | answers dict |
|---|---|---|---|
Efficient generation of integration-free ips cells from human adult peripheral blood using BCL-XL together with Yamanaka factors. The ability to efficiently generate integration-free induced pluripotent stem cells (iPSCs) from the most readily available source-peripheral blood-has the potential to expedite the advances... | Which are the Yamanaka factors? | 53137541e3eabad021000010_001 | {
"answer_start": [
610
],
"text": [
"OCT4"
]
} |
Efficient generation of integration-free ips cells from human adult peripheral blood using BCL-XL together with Yamanaka factors. The ability to efficiently generate integration-free induced pluripotent stem cells (iPSCs) from the most readily available source-peripheral blood-has the potential to expedite the advances... | Which are the Yamanaka factors? | 53137541e3eabad021000010_002 | {
"answer_start": [
616
],
"text": [
"SOX2"
]
} |
Efficient generation of integration-free ips cells from human adult peripheral blood using BCL-XL together with Yamanaka factors. The ability to efficiently generate integration-free induced pluripotent stem cells (iPSCs) from the most readily available source-peripheral blood-has the potential to expedite the advances... | Which are the Yamanaka factors? | 53137541e3eabad021000010_003 | {
"answer_start": [
622
],
"text": [
"MYC"
]
} |
Efficient generation of integration-free ips cells from human adult peripheral blood using BCL-XL together with Yamanaka factors. The ability to efficiently generate integration-free induced pluripotent stem cells (iPSCs) from the most readily available source-peripheral blood-has the potential to expedite the advances... | Which are the Yamanaka factors? | 53137541e3eabad021000010_004 | {
"answer_start": [
631
],
"text": [
"KLF4"
]
} |
Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. The 'Yamanaka factors' (Oct4, Sox2, Klf4 and c-Myc) are able to generate induced pluripotent stem (iPS) cells from different cell types. However, to what degree primary malignant cells can be reprogrammed into a pluripotent state has not been vigorous... | Which are the Yamanaka factors? | 53137541e3eabad021000010_005 | {
"answer_start": [
93
],
"text": [
"Oct4"
]
} |
Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. The 'Yamanaka factors' (Oct4, Sox2, Klf4 and c-Myc) are able to generate induced pluripotent stem (iPS) cells from different cell types. However, to what degree primary malignant cells can be reprogrammed into a pluripotent state has not been vigorous... | Which are the Yamanaka factors? | 53137541e3eabad021000010_006 | {
"answer_start": [
99
],
"text": [
"Sox2"
]
} |
Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. The 'Yamanaka factors' (Oct4, Sox2, Klf4 and c-Myc) are able to generate induced pluripotent stem (iPS) cells from different cell types. However, to what degree primary malignant cells can be reprogrammed into a pluripotent state has not been vigorous... | Which are the Yamanaka factors? | 53137541e3eabad021000010_007 | {
"answer_start": [
116
],
"text": [
"Myc"
]
} |
Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. The 'Yamanaka factors' (Oct4, Sox2, Klf4 and c-Myc) are able to generate induced pluripotent stem (iPS) cells from different cell types. However, to what degree primary malignant cells can be reprogrammed into a pluripotent state has not been vigorous... | Which are the Yamanaka factors? | 53137541e3eabad021000010_009 | {
"answer_start": [
105
],
"text": [
"Klf4"
]
} |
Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation. The recently established reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by Takahashi and Yamanaka represents a valuable tool for future therapeutic applications. To date, the mechanisms under... | Which are the Yamanaka factors? | 53137541e3eabad021000010_010 | {
"answer_start": [
422
],
"text": [
"Oct4"
]
} |
Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation. The recently established reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by Takahashi and Yamanaka represents a valuable tool for future therapeutic applications. To date, the mechanisms under... | Which are the Yamanaka factors? | 53137541e3eabad021000010_011 | {
"answer_start": [
428
],
"text": [
"Sox2"
]
} |
Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation. The recently established reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by Takahashi and Yamanaka represents a valuable tool for future therapeutic applications. To date, the mechanisms under... | Which are the Yamanaka factors? | 53137541e3eabad021000010_012 | {
"answer_start": [
446
],
"text": [
"Myc"
]
} |
Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation. The recently established reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by Takahashi and Yamanaka represents a valuable tool for future therapeutic applications. To date, the mechanisms under... | Which are the Yamanaka factors? | 53137541e3eabad021000010_014 | {
"answer_start": [
434
],
"text": [
"Klf4"
]
} |
Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma. Signal transducer and activator of transcription (STAT) 3, a member of a family of DNA-binding molecules, is a potential target in the treatment of cancer. The highly phosphorylated STAT3 in cancer... | Which are the Yamanaka factors? | 53137541e3eabad021000010_016 | {
"answer_start": [
980
],
"text": [
"SOX2"
]
} |
Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma. Signal transducer and activator of transcription (STAT) 3, a member of a family of DNA-binding molecules, is a potential target in the treatment of cancer. The highly phosphorylated STAT3 in cancer... | Which are the Yamanaka factors? | 53137541e3eabad021000010_017 | {
"answer_start": [
958
],
"text": [
"myc"
]
} |
Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma. Signal transducer and activator of transcription (STAT) 3, a member of a family of DNA-binding molecules, is a potential target in the treatment of cancer. The highly phosphorylated STAT3 in cancer... | Which are the Yamanaka factors? | 53137541e3eabad021000010_019 | {
"answer_start": [
963
],
"text": [
"KLF4"
]
} |
Blood - SeV derived fibroblast generated iPSCs. CytoTune-iPS Reprogramming System uses vectors based on replication in competent Sendai virus (SeV) to safely and effectively deliver and express key genetic factors necessary for reprogramming somatic cells into iPSCs. In contrast to many available protocols, which rely ... | Which are the Yamanaka factors? | 53137541e3eabad021000010_020 | {
"answer_start": [
893
],
"text": [
"Oct4"
]
} |
Blood - SeV derived fibroblast generated iPSCs. CytoTune-iPS Reprogramming System uses vectors based on replication in competent Sendai virus (SeV) to safely and effectively deliver and express key genetic factors necessary for reprogramming somatic cells into iPSCs. In contrast to many available protocols, which rely ... | Which are the Yamanaka factors? | 53137541e3eabad021000010_021 | {
"answer_start": [
899
],
"text": [
"Sox2"
]
} |
Blood - SeV derived fibroblast generated iPSCs. CytoTune-iPS Reprogramming System uses vectors based on replication in competent Sendai virus (SeV) to safely and effectively deliver and express key genetic factors necessary for reprogramming somatic cells into iPSCs. In contrast to many available protocols, which rely ... | Which are the Yamanaka factors? | 53137541e3eabad021000010_022 | {
"answer_start": [
917
],
"text": [
"Myc"
]
} |
Blood - SeV derived fibroblast generated iPSCs. CytoTune-iPS Reprogramming System uses vectors based on replication in competent Sendai virus (SeV) to safely and effectively deliver and express key genetic factors necessary for reprogramming somatic cells into iPSCs. In contrast to many available protocols, which rely ... | Which are the Yamanaka factors? | 53137541e3eabad021000010_024 | {
"answer_start": [
905
],
"text": [
"Klf4"
]
} |
Generation of transgene-free induced pluripotent stem cells with non-viral methods. Induced pluripotent stem (iPS) cells were originally generated from mouse fibroblasts by enforced expression of Yamanaka factors (Oct3/4, Sox2, Klf4, and c-Myc). The technique was quickly reproduced with human fibroblasts or mesenchymal... | Which are the Yamanaka factors? | 53137541e3eabad021000010_026 | {
"answer_start": [
222
],
"text": [
"Sox2"
]
} |
Generation of transgene-free induced pluripotent stem cells with non-viral methods. Induced pluripotent stem (iPS) cells were originally generated from mouse fibroblasts by enforced expression of Yamanaka factors (Oct3/4, Sox2, Klf4, and c-Myc). The technique was quickly reproduced with human fibroblasts or mesenchymal... | Which are the Yamanaka factors? | 53137541e3eabad021000010_027 | {
"answer_start": [
240
],
"text": [
"Myc"
]
} |
Generation of transgene-free induced pluripotent stem cells with non-viral methods. Induced pluripotent stem (iPS) cells were originally generated from mouse fibroblasts by enforced expression of Yamanaka factors (Oct3/4, Sox2, Klf4, and c-Myc). The technique was quickly reproduced with human fibroblasts or mesenchymal... | Which are the Yamanaka factors? | 53137541e3eabad021000010_029 | {
"answer_start": [
228
],
"text": [
"Klf4"
]
} |
HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks. BACKGROUND: Although recent studies have identified genes expressed in human embryonic stem cells (hESCs) that induce pluripotency, the molecular underpinnings of normal stem cell function remain poorly understood... | Which are the Yamanaka factors? | 53137541e3eabad021000010_030 | {
"answer_start": [
964
],
"text": [
"OCT4"
]
} |
HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks. BACKGROUND: Although recent studies have identified genes expressed in human embryonic stem cells (hESCs) that induce pluripotency, the molecular underpinnings of normal stem cell function remain poorly understood... | Which are the Yamanaka factors? | 53137541e3eabad021000010_031 | {
"answer_start": [
970
],
"text": [
"SOX2"
]
} |
HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks. BACKGROUND: Although recent studies have identified genes expressed in human embryonic stem cells (hESCs) that induce pluripotency, the molecular underpinnings of normal stem cell function remain poorly understood... | Which are the Yamanaka factors? | 53137541e3eabad021000010_032 | {
"answer_start": [
983
],
"text": [
"MYC"
]
} |
HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks. BACKGROUND: Although recent studies have identified genes expressed in human embryonic stem cells (hESCs) that induce pluripotency, the molecular underpinnings of normal stem cell function remain poorly understood... | Which are the Yamanaka factors? | 53137541e3eabad021000010_033 | {
"answer_start": [
976
],
"text": [
"KLF4"
]
} |
DNp73 improves generation efficiency of human induced pluripotent stem cells. BACKGROUND: Recent studies have found that p53 and its' associated cell cycle pathways are major inhibitors of human induced pluripotent stem (iPS) cell generation. In the same family as p53 is p73, which shares sequence similarities with p53... | Which are the Yamanaka factors? | 53137541e3eabad021000010_034 | {
"answer_start": [
754
],
"text": [
"Oct4"
]
} |
DNp73 improves generation efficiency of human induced pluripotent stem cells. BACKGROUND: Recent studies have found that p53 and its' associated cell cycle pathways are major inhibitors of human induced pluripotent stem (iPS) cell generation. In the same family as p53 is p73, which shares sequence similarities with p53... | Which are the Yamanaka factors? | 53137541e3eabad021000010_035 | {
"answer_start": [
760
],
"text": [
"Sox2"
]
} |
DNp73 improves generation efficiency of human induced pluripotent stem cells. BACKGROUND: Recent studies have found that p53 and its' associated cell cycle pathways are major inhibitors of human induced pluripotent stem (iPS) cell generation. In the same family as p53 is p73, which shares sequence similarities with p53... | Which are the Yamanaka factors? | 53137541e3eabad021000010_036 | {
"answer_start": [
776
],
"text": [
"Myc"
]
} |
DNp73 improves generation efficiency of human induced pluripotent stem cells. BACKGROUND: Recent studies have found that p53 and its' associated cell cycle pathways are major inhibitors of human induced pluripotent stem (iPS) cell generation. In the same family as p53 is p73, which shares sequence similarities with p53... | Which are the Yamanaka factors? | 53137541e3eabad021000010_037 | {
"answer_start": [
766
],
"text": [
"Klf4"
]
} |
In vitro transformation of mouse testis cells by oncogene transfection. Germ cell tumors (GCTs) are unique in that they exhibit diverse biological characteristics and pathological features. Although several in vivo GCT models are available, studies on GCTs are hampered because in vivo development of GCTs is time consum... | Which are the Yamanaka factors? | 53137541e3eabad021000010_039 | {
"answer_start": [
920
],
"text": [
"Sox2"
]
} |
In vitro transformation of mouse testis cells by oncogene transfection. Germ cell tumors (GCTs) are unique in that they exhibit diverse biological characteristics and pathological features. Although several in vivo GCT models are available, studies on GCTs are hampered because in vivo development of GCTs is time consum... | Which are the Yamanaka factors? | 53137541e3eabad021000010_040 | {
"answer_start": [
905
],
"text": [
"Myc"
]
} |
In vitro transformation of mouse testis cells by oncogene transfection. Germ cell tumors (GCTs) are unique in that they exhibit diverse biological characteristics and pathological features. Although several in vivo GCT models are available, studies on GCTs are hampered because in vivo development of GCTs is time consum... | Which are the Yamanaka factors? | 53137541e3eabad021000010_041 | {
"answer_start": [
910
],
"text": [
"Klf4"
]
} |
Induction of pluripotent stem cells from fetal and adult cynomolgus monkey fibroblasts using four human transcription factors. Induced pluripotent stem (iPS) cells have the potential to become a universal resource for cell-based therapies in regenerative medicine; however, prior to the use of such iPS cell-based therap... | Which are the Yamanaka factors? | 53137541e3eabad021000010_043 | {
"answer_start": [
699
],
"text": [
"Sox2"
]
} |
Induction of pluripotent stem cells from fetal and adult cynomolgus monkey fibroblasts using four human transcription factors. Induced pluripotent stem (iPS) cells have the potential to become a universal resource for cell-based therapies in regenerative medicine; however, prior to the use of such iPS cell-based therap... | Which are the Yamanaka factors? | 53137541e3eabad021000010_044 | {
"answer_start": [
676
],
"text": [
"Myc"
]
} |
Induction of pluripotent stem cells from fetal and adult cynomolgus monkey fibroblasts using four human transcription factors. Induced pluripotent stem (iPS) cells have the potential to become a universal resource for cell-based therapies in regenerative medicine; however, prior to the use of such iPS cell-based therap... | Which are the Yamanaka factors? | 53137541e3eabad021000010_046 | {
"answer_start": [
681
],
"text": [
"Klf4"
]
} |
Induction of pluripotent stem cells from autopsy donor-derived somatic cells. Human induced pluripotent stem cells (iPSCs) have become an intriguing approach for neurological disease modeling, because neural lineage-specific cell types that retain the donors' complex genetics can be established in vitro. The statistica... | Which are the Yamanaka factors? | 53137541e3eabad021000010_048 | {
"answer_start": [
1106
],
"text": [
"Sox2"
]
} |
Induction of pluripotent stem cells from autopsy donor-derived somatic cells. Human induced pluripotent stem cells (iPSCs) have become an intriguing approach for neurological disease modeling, because neural lineage-specific cell types that retain the donors' complex genetics can be established in vitro. The statistica... | Which are the Yamanaka factors? | 53137541e3eabad021000010_049 | {
"answer_start": [
1124
],
"text": [
"Myc"
]
} |
Induction of pluripotent stem cells from autopsy donor-derived somatic cells. Human induced pluripotent stem cells (iPSCs) have become an intriguing approach for neurological disease modeling, because neural lineage-specific cell types that retain the donors' complex genetics can be established in vitro. The statistica... | Which are the Yamanaka factors? | 53137541e3eabad021000010_051 | {
"answer_start": [
1112
],
"text": [
"Klf4"
]
} |
Protein intrinsic disorder and induced pluripotent stem cells. Induced pluripotent stem (iPS) cells can be obtained from terminally differentiated somatic cells by overexpression of defined sets of reprogramming transcription factors. These protein sets have been called the Yamanaka factors, namely Sox2, Oct3/4 (Pou5f1... | Which are the Yamanaka factors? | 53137541e3eabad021000010_054 | {
"answer_start": [
300
],
"text": [
"Sox2"
]
} |
Protein intrinsic disorder and induced pluripotent stem cells. Induced pluripotent stem (iPS) cells can be obtained from terminally differentiated somatic cells by overexpression of defined sets of reprogramming transcription factors. These protein sets have been called the Yamanaka factors, namely Sox2, Oct3/4 (Pou5f1... | Which are the Yamanaka factors? | 53137541e3eabad021000010_055 | {
"answer_start": [
335
],
"text": [
"Myc"
]
} |
Protein intrinsic disorder and induced pluripotent stem cells. Induced pluripotent stem (iPS) cells can be obtained from terminally differentiated somatic cells by overexpression of defined sets of reprogramming transcription factors. These protein sets have been called the Yamanaka factors, namely Sox2, Oct3/4 (Pou5f1... | Which are the Yamanaka factors? | 53137541e3eabad021000010_057 | {
"answer_start": [
323
],
"text": [
"Klf4"
]
} |
Selection of alkaline phosphatase-positive induced pluripotent stem cells from human amniotic fluid-derived cells by feeder-free system. Generation of induced pluripotent stem (iPS) cells from somatic cells has been successfully achieved by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and c-Myc, a... | Which are the Yamanaka factors? | 53137541e3eabad021000010_058 | {
"answer_start": [
291
],
"text": [
"Oct4"
]
} |
Selection of alkaline phosphatase-positive induced pluripotent stem cells from human amniotic fluid-derived cells by feeder-free system. Generation of induced pluripotent stem (iPS) cells from somatic cells has been successfully achieved by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and c-Myc, a... | Which are the Yamanaka factors? | 53137541e3eabad021000010_059 | {
"answer_start": [
297
],
"text": [
"Sox2"
]
} |
Selection of alkaline phosphatase-positive induced pluripotent stem cells from human amniotic fluid-derived cells by feeder-free system. Generation of induced pluripotent stem (iPS) cells from somatic cells has been successfully achieved by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and c-Myc, a... | Which are the Yamanaka factors? | 53137541e3eabad021000010_060 | {
"answer_start": [
314
],
"text": [
"Myc"
]
} |
Selection of alkaline phosphatase-positive induced pluripotent stem cells from human amniotic fluid-derived cells by feeder-free system. Generation of induced pluripotent stem (iPS) cells from somatic cells has been successfully achieved by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and c-Myc, a... | Which are the Yamanaka factors? | 53137541e3eabad021000010_062 | {
"answer_start": [
303
],
"text": [
"Klf4"
]
} |
Generation of human melanocytes from induced pluripotent stem cells. Epidermal melanocytes play an important role in protecting the skin from UV rays, and their functional impairment results in pigment disorders. Additionally, melanomas are considered to arise from mutations that accumulate in melanocyte stem cells. Th... | Which are the Yamanaka factors? | 53137541e3eabad021000010_064 | {
"answer_start": [
738
],
"text": [
"SOX2"
]
} |
Generation of human melanocytes from induced pluripotent stem cells. Epidermal melanocytes play an important role in protecting the skin from UV rays, and their functional impairment results in pigment disorders. Additionally, melanomas are considered to arise from mutations that accumulate in melanocyte stem cells. Th... | Which are the Yamanaka factors? | 53137541e3eabad021000010_065 | {
"answer_start": [
780
],
"text": [
"MYC"
]
} |
Generation of human melanocytes from induced pluripotent stem cells. Epidermal melanocytes play an important role in protecting the skin from UV rays, and their functional impairment results in pigment disorders. Additionally, melanomas are considered to arise from mutations that accumulate in melanocyte stem cells. Th... | Which are the Yamanaka factors? | 53137541e3eabad021000010_067 | {
"answer_start": [
756
],
"text": [
"KLF4"
]
} |
The efficient generation of induced pluripotent stem (iPS) cells from adult mouse adipose tissue-derived and neural stem cells. Ectopic expression of key reprogramming transgenes in somatic cells enables them to adopt the characteristics of pluripotency. Such cells have been termed induced pluripotent stem (iPS) cells ... | Which are the Yamanaka factors? | 53137541e3eabad021000010_068 | {
"answer_start": [
911
],
"text": [
"Oct4"
]
} |
The efficient generation of induced pluripotent stem (iPS) cells from adult mouse adipose tissue-derived and neural stem cells. Ectopic expression of key reprogramming transgenes in somatic cells enables them to adopt the characteristics of pluripotency. Such cells have been termed induced pluripotent stem (iPS) cells ... | Which are the Yamanaka factors? | 53137541e3eabad021000010_069 | {
"answer_start": [
917
],
"text": [
"Sox2"
]
} |
The efficient generation of induced pluripotent stem (iPS) cells from adult mouse adipose tissue-derived and neural stem cells. Ectopic expression of key reprogramming transgenes in somatic cells enables them to adopt the characteristics of pluripotency. Such cells have been termed induced pluripotent stem (iPS) cells ... | Which are the Yamanaka factors? | 53137541e3eabad021000010_070 | {
"answer_start": [
935
],
"text": [
"Myc"
]
} |
The efficient generation of induced pluripotent stem (iPS) cells from adult mouse adipose tissue-derived and neural stem cells. Ectopic expression of key reprogramming transgenes in somatic cells enables them to adopt the characteristics of pluripotency. Such cells have been termed induced pluripotent stem (iPS) cells ... | Which are the Yamanaka factors? | 53137541e3eabad021000010_072 | {
"answer_start": [
923
],
"text": [
"Klf4"
]
} |
Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors r... | Which are the Yamanaka factors? | 53137541e3eabad021000010_074 | {
"answer_start": [
130
],
"text": [
"Sox2"
]
} |
Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors r... | Which are the Yamanaka factors? | 53137541e3eabad021000010_075 | {
"answer_start": [
144
],
"text": [
"Myc"
]
} |
Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors r... | Which are the Yamanaka factors? | 53137541e3eabad021000010_077 | {
"answer_start": [
136
],
"text": [
"Klf4"
]
} |
Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors r... | Which are the Yamanaka factors? | 53137541e3eabad021000010_079 | {
"answer_start": [
130
],
"text": [
"Sox2"
]
} |
Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors r... | Which are the Yamanaka factors? | 53137541e3eabad021000010_080 | {
"answer_start": [
144
],
"text": [
"Myc"
]
} |
Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors r... | Which are the Yamanaka factors? | 53137541e3eabad021000010_082 | {
"answer_start": [
136
],
"text": [
"Klf4"
]
} |
Protein intrinsic disorder and induced pluripotent stem cells. Induced pluripotent stem (iPS) cells can be obtained from terminally differentiated somatic cells by overexpression of defined sets of reprogramming transcription factors. These protein sets have been called the Yamanaka factors, namely Sox2, Oct3/4 (Pou5f1... | Which are the Yamanaka factors? | 53137541e3eabad021000010_085 | {
"answer_start": [
300
],
"text": [
"Sox2"
]
} |
Protein intrinsic disorder and induced pluripotent stem cells. Induced pluripotent stem (iPS) cells can be obtained from terminally differentiated somatic cells by overexpression of defined sets of reprogramming transcription factors. These protein sets have been called the Yamanaka factors, namely Sox2, Oct3/4 (Pou5f1... | Which are the Yamanaka factors? | 53137541e3eabad021000010_086 | {
"answer_start": [
372
],
"text": [
"Sox2"
]
} |
Protein intrinsic disorder and induced pluripotent stem cells. Induced pluripotent stem (iPS) cells can be obtained from terminally differentiated somatic cells by overexpression of defined sets of reprogramming transcription factors. These protein sets have been called the Yamanaka factors, namely Sox2, Oct3/4 (Pou5f1... | Which are the Yamanaka factors? | 53137541e3eabad021000010_087 | {
"answer_start": [
335
],
"text": [
"Myc"
]
} |
Protein intrinsic disorder and induced pluripotent stem cells. Induced pluripotent stem (iPS) cells can be obtained from terminally differentiated somatic cells by overexpression of defined sets of reprogramming transcription factors. These protein sets have been called the Yamanaka factors, namely Sox2, Oct3/4 (Pou5f1... | Which are the Yamanaka factors? | 53137541e3eabad021000010_089 | {
"answer_start": [
323
],
"text": [
"Klf4"
]
} |
Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors r... | Which are the Yamanaka factors? | 53137541e3eabad021000010_091 | {
"answer_start": [
130
],
"text": [
"Sox2"
]
} |
Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors r... | Which are the Yamanaka factors? | 53137541e3eabad021000010_092 | {
"answer_start": [
144
],
"text": [
"Myc"
]
} |
Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors r... | Which are the Yamanaka factors? | 53137541e3eabad021000010_094 | {
"answer_start": [
136
],
"text": [
"Klf4"
]
} |
DNp73 improves generation efficiency of human induced pluripotent stem cells. BACKGROUND: Recent studies have found that p53 and its' associated cell cycle pathways are major inhibitors of human induced pluripotent stem (iPS) cell generation. In the same family as p53 is p73, which shares sequence similarities with p53... | Which are the Yamanaka factors? | 53137541e3eabad021000010_095 | {
"answer_start": [
754
],
"text": [
"Oct4"
]
} |
DNp73 improves generation efficiency of human induced pluripotent stem cells. BACKGROUND: Recent studies have found that p53 and its' associated cell cycle pathways are major inhibitors of human induced pluripotent stem (iPS) cell generation. In the same family as p53 is p73, which shares sequence similarities with p53... | Which are the Yamanaka factors? | 53137541e3eabad021000010_096 | {
"answer_start": [
760
],
"text": [
"Sox2"
]
} |
DNp73 improves generation efficiency of human induced pluripotent stem cells. BACKGROUND: Recent studies have found that p53 and its' associated cell cycle pathways are major inhibitors of human induced pluripotent stem (iPS) cell generation. In the same family as p53 is p73, which shares sequence similarities with p53... | Which are the Yamanaka factors? | 53137541e3eabad021000010_097 | {
"answer_start": [
776
],
"text": [
"Myc"
]
} |
DNp73 improves generation efficiency of human induced pluripotent stem cells. BACKGROUND: Recent studies have found that p53 and its' associated cell cycle pathways are major inhibitors of human induced pluripotent stem (iPS) cell generation. In the same family as p53 is p73, which shares sequence similarities with p53... | Which are the Yamanaka factors? | 53137541e3eabad021000010_098 | {
"answer_start": [
766
],
"text": [
"Klf4"
]
} |
Selection of alkaline phosphatase-positive induced pluripotent stem cells from human amniotic fluid-derived cells by feeder-free system. Generation of induced pluripotent stem (iPS) cells from somatic cells has been successfully achieved by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and c-Myc, a... | Which are the Yamanaka factors? | 53137541e3eabad021000010_099 | {
"answer_start": [
291
],
"text": [
"Oct4"
]
} |
Selection of alkaline phosphatase-positive induced pluripotent stem cells from human amniotic fluid-derived cells by feeder-free system. Generation of induced pluripotent stem (iPS) cells from somatic cells has been successfully achieved by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and c-Myc, a... | Which are the Yamanaka factors? | 53137541e3eabad021000010_100 | {
"answer_start": [
297
],
"text": [
"Sox2"
]
} |
Selection of alkaline phosphatase-positive induced pluripotent stem cells from human amniotic fluid-derived cells by feeder-free system. Generation of induced pluripotent stem (iPS) cells from somatic cells has been successfully achieved by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and c-Myc, a... | Which are the Yamanaka factors? | 53137541e3eabad021000010_101 | {
"answer_start": [
314
],
"text": [
"Myc"
]
} |
Selection of alkaline phosphatase-positive induced pluripotent stem cells from human amniotic fluid-derived cells by feeder-free system. Generation of induced pluripotent stem (iPS) cells from somatic cells has been successfully achieved by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and c-Myc, a... | Which are the Yamanaka factors? | 53137541e3eabad021000010_103 | {
"answer_start": [
303
],
"text": [
"Klf4"
]
} |
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Mutations in the POLG gene have emerged as one of the most common causes of inherited mitochondrial disease in children and adults. They are responsible for a heterogeneous group of at least 6 major phenotypes of neurodegenerative disease ... | Which currently known mitochondrial diseases have been attributed to POLG mutations? | 5718bbb37de986d80d00000b_001 | {
"answer_start": [
337
],
"text": [
"childhood Myocerebrohepatopathy Spectrum disorders (MCHS)"
]
} |
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Mutations in the POLG gene have emerged as one of the most common causes of inherited mitochondrial disease in children and adults. They are responsible for a heterogeneous group of at least 6 major phenotypes of neurodegenerative disease ... | Which currently known mitochondrial diseases have been attributed to POLG mutations? | 5718bbb37de986d80d00000b_002 | {
"answer_start": [
399
],
"text": [
"Alpers syndrome"
]
} |
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Mutations in the POLG gene have emerged as one of the most common causes of inherited mitochondrial disease in children and adults. They are responsible for a heterogeneous group of at least 6 major phenotypes of neurodegenerative disease ... | Which currently known mitochondrial diseases have been attributed to POLG mutations? | 5718bbb37de986d80d00000b_003 | {
"answer_start": [
419
],
"text": [
"Ataxia Neuropathy Spectrum (ANS) disorders"
]
} |
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Mutations in the POLG gene have emerged as one of the most common causes of inherited mitochondrial disease in children and adults. They are responsible for a heterogeneous group of at least 6 major phenotypes of neurodegenerative disease ... | Which currently known mitochondrial diseases have been attributed to POLG mutations? | 5718bbb37de986d80d00000b_004 | {
"answer_start": [
466
],
"text": [
"Myoclonus Epilepsy Myopathy Sensory Ataxia (MEMSA)"
]
} |
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Mutations in the POLG gene have emerged as one of the most common causes of inherited mitochondrial disease in children and adults. They are responsible for a heterogeneous group of at least 6 major phenotypes of neurodegenerative disease ... | Which currently known mitochondrial diseases have been attributed to POLG mutations? | 5718bbb37de986d80d00000b_005 | {
"answer_start": [
521
],
"text": [
"autosomal recessive Progressive External Ophthalmoplegia (arPEO)"
]
} |
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Mutations in the POLG gene have emerged as one of the most common causes of inherited mitochondrial disease in children and adults. They are responsible for a heterogeneous group of at least 6 major phenotypes of neurodegenerative disease ... | Which currently known mitochondrial diseases have been attributed to POLG mutations? | 5718bbb37de986d80d00000b_006 | {
"answer_start": [
594
],
"text": [
"autosomal dominant Progressive External Ophthalmoplegia (adPEO)"
]
} |
Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations. DNA polymerase γ (pol γ), encoded by POLG, is responsible for replicating human mitochondrial DNA. About 150 mutations in the human POLG have been identified in patients with mitochondrial diseases such as Alpers syndrome, progressive ... | Which currently known mitochondrial diseases have been attributed to POLG mutations? | 5718bbb37de986d80d00000b_007 | {
"answer_start": [
291
],
"text": [
"Alpers syndrome"
]
} |
Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes. Calsequestrin (CSQ) is a Ca(2+) storage protein that interacts with triadin (TRN), the ryanodine receptor (RyR), and junctin (JUN) to form a macromolecular tetrameric Ca(2+) signaling complex in the cardiac junctional sarcoplas... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_001 | {
"answer_start": [
180
],
"text": [
"ryanodine receptor"
]
} |
Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes. Calsequestrin (CSQ) is a Ca(2+) storage protein that interacts with triadin (TRN), the ryanodine receptor (RyR), and junctin (JUN) to form a macromolecular tetrameric Ca(2+) signaling complex in the cardiac junctional sarcoplas... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_003 | {
"answer_start": [
93
],
"text": [
"Calsequestrin"
]
} |
Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes. Calsequestrin (CSQ) is a Ca(2+) storage protein that interacts with triadin (TRN), the ryanodine receptor (RyR), and junctin (JUN) to form a macromolecular tetrameric Ca(2+) signaling complex in the cardiac junctional sarcoplas... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_005 | {
"answer_start": [
161
],
"text": [
"triadin"
]
} |
Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes. Calsequestrin (CSQ) is a Ca(2+) storage protein that interacts with triadin (TRN), the ryanodine receptor (RyR), and junctin (JUN) to form a macromolecular tetrameric Ca(2+) signaling complex in the cardiac junctional sarcoplas... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_007 | {
"answer_start": [
210
],
"text": [
"junctin"
]
} |
Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias. RATIONALE: Catecholaminergic polymorphic ventricular tachycardia is an inherited disease that predisposes to cardiac arrest and sudden death. The disease is associated with... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_014 | {
"answer_start": [
620
],
"text": [
"Triadin"
]
} |
Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias. RATIONALE: Catecholaminergic polymorphic ventricular tachycardia is an inherited disease that predisposes to cardiac arrest and sudden death. The disease is associated with... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_016 | {
"answer_start": [
638
],
"text": [
"Junctin"
]
} |
Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. Triadin and junctin are integral sarcoplasmic reticulum membrane proteins that form a macromolecular complex with the skeletal muscle ryanodine receptor (RyR1) but their roles in skeletal muscle calcium homeostasis remain incompletely... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_019 | {
"answer_start": [
220
],
"text": [
"ryanodine receptor"
]
} |
Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. Triadin and junctin are integral sarcoplasmic reticulum membrane proteins that form a macromolecular complex with the skeletal muscle ryanodine receptor (RyR1) but their roles in skeletal muscle calcium homeostasis remain incompletely... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_021 | {
"answer_start": [
86
],
"text": [
"Triadin"
]
} |
Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. Triadin and junctin are integral sarcoplasmic reticulum membrane proteins that form a macromolecular complex with the skeletal muscle ryanodine receptor (RyR1) but their roles in skeletal muscle calcium homeostasis remain incompletely... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_022 | {
"answer_start": [
98
],
"text": [
"junctin"
]
} |
Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes. Junctin, a 26 kDa intra-sarcoplasmic reticulum (SR) protein, forms a quaternary complex with triadin, calsequestrin and the ryanodine receptor (RyR) at the junctional SR membrane. The physiological role fo... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_024 | {
"answer_start": [
239
],
"text": [
"ryanodine receptor"
]
} |
Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes. Junctin, a 26 kDa intra-sarcoplasmic reticulum (SR) protein, forms a quaternary complex with triadin, calsequestrin and the ryanodine receptor (RyR) at the junctional SR membrane. The physiological role fo... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_026 | {
"answer_start": [
217
],
"text": [
"calsequestrin"
]
} |
Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes. Junctin, a 26 kDa intra-sarcoplasmic reticulum (SR) protein, forms a quaternary complex with triadin, calsequestrin and the ryanodine receptor (RyR) at the junctional SR membrane. The physiological role fo... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_027 | {
"answer_start": [
208
],
"text": [
"triadin"
]
} |
Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes. Junctin, a 26 kDa intra-sarcoplasmic reticulum (SR) protein, forms a quaternary complex with triadin, calsequestrin and the ryanodine receptor (RyR) at the junctional SR membrane. The physiological role fo... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_028 | {
"answer_start": [
115
],
"text": [
"Junctin"
]
} |
Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling. In cardiac muscle, junctin forms a quaternary protein complex with the ryanodine receptor (RyR), calsequestrin, and triadin 1 at the luminal face of the junctional sarcoplasmic reticulum (jSR). By binding directly the RyR and calsequ... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_031 | {
"answer_start": [
158
],
"text": [
"ryanodine receptor"
]
} |
Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling. In cardiac muscle, junctin forms a quaternary protein complex with the ryanodine receptor (RyR), calsequestrin, and triadin 1 at the luminal face of the junctional sarcoplasmic reticulum (jSR). By binding directly the RyR and calsequ... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_034 | {
"answer_start": [
184
],
"text": [
"calsequestrin"
]
} |
Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling. In cardiac muscle, junctin forms a quaternary protein complex with the ryanodine receptor (RyR), calsequestrin, and triadin 1 at the luminal face of the junctional sarcoplasmic reticulum (jSR). By binding directly the RyR and calsequ... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_035 | {
"answer_start": [
313
],
"text": [
"calsequestrin"
]
} |
Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling. In cardiac muscle, junctin forms a quaternary protein complex with the ryanodine receptor (RyR), calsequestrin, and triadin 1 at the luminal face of the junctional sarcoplasmic reticulum (jSR). By binding directly the RyR and calsequ... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_036 | {
"answer_start": [
203
],
"text": [
"triadin"
]
} |
Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling. In cardiac muscle, junctin forms a quaternary protein complex with the ryanodine receptor (RyR), calsequestrin, and triadin 1 at the luminal face of the junctional sarcoplasmic reticulum (jSR). By binding directly the RyR and calsequ... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_037 | {
"answer_start": [
106
],
"text": [
"junctin"
]
} |
Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling. In cardiac muscle, junctin forms a quaternary protein complex with the ryanodine receptor (RyR), calsequestrin, and triadin 1 at the luminal face of the junctional sarcoplasmic reticulum (jSR). By binding directly the RyR and calsequ... | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | 54f9d3eedd3fc62544000004_038 | {
"answer_start": [
328
],
"text": [
"junctin"
]
} |
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