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34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-75.0, Mitral Leaflet Prolapse Age > 18 years Degenerative mitral insufficiency with mitral leaflet prolapsed , who are candidates for mitral valve repair according to ESC or ACC/AHA guidelines Patient able and willing to return to the implant center for follow-up visits Able and willing to ... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation age ≥ 18 years signed written consent symptomatic patients (NYHA-stadium ≥ III) for at least 3 months with an exploited medical heart insufficiency therapy increased perioperative risk with a logistic EuroScore ≥ 15 or STS-Score ≥ 15 MR grade ≥ 2, amenable for Mi... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Prolapse Subject has symptomatic or asymptomatic moderate (2+) or severe (3-4+) mitral regurgitation Subject has an ejection fraction (EF) ≥ 30% Subject is of legal age (≥18 years old) Subject is planned to undergo surgical repair or replacement of the mitral valve for s... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Tricuspid Valve Regurgitation, Non-rheumatic Mitral Valve Regurgitation Audible AV valve regurgitation on clinical exam, as noted by most recent clinic note Clinically indicated CMR study scheduled and have had an echocardiogram in the last 6 months Poor quality CMR study Unable to c... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-60.0, Intraarticular Fracture and Post-traumatic Osteoarthritis years of age or older Radiographic evidence of tibial plateau fracture Less than 18 years of age Greater than 60 years of age Any history of pre-existing knee osteoarthritis based on previous diagnosis or suggestive history An... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-85.0, Severe Degenerative Mitral Regurgitation Age 18 years Patients with severe degenerative mitral regurgitation undergoing mitral valve repair at our institution Functional or ischemic mitral regurgitation Presence of relevant (symptomatic) Coronary Artery Disease Inability of exercisin... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 20.0-75.0, Critical Stenosis of Aortic Valve Male or female Age: 20-75 years Moderate to severe aortic stenosis defined as a continuous wave Doppler determined peak aortic valve jet velocity of 3.0 5 m/s, mean pressure gradient of 25 mmHg, or aortic valve area of 0.76 5 cm2 Asymptomatic aortic s... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-70.0, Morbid Obesity Qualify for gastric bypass or sleeve gastrectomy (fertile females with negative pregnancy test) Willing to comply with scheduled follow up appointments Blood pressure < 140/80 and heart rate < 100 measured three times Treated hypertension with blood pressure still > 14... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 20.0-65.0, Pulmonary Hypertension Mitral Regurgitation patients undergoing mitral valve surgery for chronic mitral regurgitation estimated pulmonary hypertension (systolic PAP > 50 mmHg estimated by the velocity of tricuspid valve regurgitation in preoperative transthoracic echocardiography) pat... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Age ≥ 18 years Severe aortic stenosis (AS) based on overall clinical impression, with or without aortic valve mean gradient ≥ 40 mm Hg, EOA < 1.0 cm2, or EOA index < 0.6 cm2/m2 Scheduled for clinically indicated elective aortic valve replacement for a primary di... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Pulmonary Hypertension Mitral Valve Disease Age > 18 years Greater than 6 months post-mechanical or bioprosthetic mitral valve replacement or mitral valve repair (quadrangular resection, triangular resection, sliding plasty, and/or annuloplasty) surgery Dyspnea at rest or with exerti... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Severe Aortic Stenosis Subject must have co-morbidities such that one cardiologist and two cardiac surgeons agree that medical factors preclude operation, based on a conclusion that the probability of death or serious morbidity exceeds the probability of meaningful improvement. Specif... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-85.0, Mitral Regurgitation Mitral Insufficiency Eligible patients must meet all the following 1. Signed Informed Consent Form. 2. Male or female aged ≥18 to ≤ 85 years on the day of screening. Females of childbearing potential (not surgically sterilized or more than one year post-menopausal... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Repair Surgery patients scheduled to undergo elective mitral valve repair surgery more than moderate mitral stenosis left atrial enlargement signed written informed consent agreements urgent or emergency case other concurrent valvular surgery patient age < 18 years redu... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Aortic Valve Stenosis With Insufficiency Regurgitation, Aortic Valve Aortic Valve Incompetence Subjects will be required to meet all 1. Male or female, age 18 years or older 2. Has aortic stenosis or stenosis-insufficiency of an aortic valve requiring a planned ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 20.0-80.0, Mitral Regurgitation asymptomatic patients severe degenerative MR preserved left ventricular systolic function According to the recommendations of the 2006 American College of Cardiology/American Heart Association (ACC/AHA) guidelines for surgical indications of severe MR, the for fr... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Marfan Syndrome Man or woman > 18 years old With a mutation in FBN1 gene Has signed an informed consent form -No affiliated to a Healthcare System | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-75.0, Heart; Disease, Mitral(Valve) Diseases of Mitral Valve Mitral Valve Insufficiency Asymptomatic Severe organic mitral valve regurgitation Preserved left ventricular function (left ventricular ejection fraction >60% and left ventricular end-systolic dimension ≤45 mm) The likelihood of M... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-80.0, Mitral Valve Prolapse Mitral valve prolapse Other mitral valve diseases | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Aortic Insufficiency Subject is 18 years of age or older Subject has tri-leaflet aortic valve morphology Subject has documented aortic valve disease which may or may not 1. aortic valve insufficiency 2. aortic root pathology 3. pathology of the ascending aorta 4. patients with associ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, 3D Transesophageal and Transthoracic Echocardiogram Elective coronary artery bypass grafting surgery, valve repair or replacement surgery, aortic repair or replacement surgery, or any combination of these surgeries years or older for thermodilution assessment are as follows Moderate... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation NYHA II-IV Structurally normal mitral valve At least Grade 2 mitral regurgitation Left ventricular ejection fraction not less than 20% and not greater than 45% Left ventricular end diastolic diameter not less than 5.0 cm and not greater than 7.5 cm Pregnan... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 65.0-999.0, Severe Symptomatic Aortic Stenosis Subject has signed the study Informed Consent Form and Data Protection Form prior to participating in the study. 2. Subject is 65 years of age or older at the time of index procedure, and/or has comorbidities that, in the opinion of the Principal In... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-90.0, Turner Syndrome Bicuspid Aortic Valve Marfan Syndrome Turner syndrome (TS). A TS verified by genotyping Age > 18 years Awaiting operation due to aortic dilation B Previous aortic dissection or operation of the aorta (per-cutaneous or open surgery) Marfan syndrome (MS) A Females with M... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-79.0, Mitral Valve Regurgitation Age >= 18 and < 80 years Candidate for surgical mitral valve repair or replacement Isolated posterior leaflet prolapse Moderate to severe or severe mitral valve regurgitation that is degenerative in nature Anterior or bi-leaflet prolapse Functional or ische... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Mitral Valve Insufficiency Heart Valve Diseases Heart Diseases Cardiovascular Diseases Grade 3+ or 4+ mitral valve regurgitation Heavily calcified valves Valvular retraction with severely reduced mobility Active bacterial endocarditis Complex mechanism of MR (leaflet perforation, etc... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Mitral Valve Repair Patients with Mitral valve prolapse who undergo mitral valve repair using neochorda Nothing | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 21.0-999.0, Mitral Valve Insufficiency Age > 18 or 21 years (Legal age according to the countries involved in this study) Presence of at least moderate chronic OMR defined as an ERO ≥20mm2 and/or a regurgitant volume ≥30mL MR due to ischemic heart disease or cardiomyopathy > mild mitral stenosi... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Age > 18 years Moderate to severe functional Mitral Regurgitation (MR) Symptomatic Patients (NYHA ClassII-IV) despite optimal medical therapy , including Cardiac Resynchronization (CRT) if indicated Left Ventricle Ejection Fraction (LVEF) ≥ 25%, LVEDD ≤ 65mm Subj... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-50.0, Gestational Diabetes Obesity Pregnant years and older Body mass index >=30.0 <20 weeks gestation at presentation for care Prior cesarean History of bariatric surgery Major maternal medical illness (cardiac disease, HIV, hemoglobinopathy, oxygen requirement) Chronic prednisone use Kno... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Aortic Stenosis Severe aortic stenosis, defined as aortic valve area of < 1.0 cm2 (or aortic valve area index of < 0.6 cm2/m2) by the continuity equation, AND mean gradient > 40 mmHg or maximal aortic valve velocity > 4.0 m/sec by resting echocardiogram. 2. Estimated 30 day mortality ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-65.0, Healthy Healthy males and females, non-vegetarians, non-smokers, age 18-65 with BMI 18-35 kg m-2, taking no medication Diabetes Severe gastrointestinal disorders Kidney disease Thromboembolic or coagulation disease Hepatic disease Alcohol or any other substance abuse Gout Eating diso... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Functional Mitral Regurgitation Age >18 years Subjects with clinically significant mitral regurgitation (MR 2+ and above) Ejection Fraction ≥ 25% Stable cardiac medical regimen for heart failure for at least 1 month Stable NYHA Classification for at least 1 month Subject is eligible ... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Cardiovascular Diseases Age > 18 years old Severe secondary mitral regurgitation characterised, according to the European guidelines and recommendations, by a regurgitant volume>30 mL/beat or an effective regurgitant orifice>20 mm² New York heart Association Class≥ II Left ventricula... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Insufficiency Mitral Valve Regurgitation Mitral Valve Incompetence Mitral Regurgitation Mitral Insufficiency Patients screened in II Study will first be screened for high risk (HR) status and enrolled into the HR arm if they meet for this arm of the study. If they do not... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-45.0, Vitamin D3 Deficiency Any mother (18-45 years of age) who presents to her obstetrician or midwife at the Medical University of SC (MUSC), Charleston, SC obstetrical facilities within the first 14 weeks after her last menstrual period (LMP) with confirmation of a singleton pregnancy wi... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Insufficiency Mitral Valve Regurgitation Mitral Valve Incompetence Mitral Regurgitation Mitral Insufficiency Candidates for the high risk arm of the study must meet all of the following Predicted procedural mortality risk calculated using the STS surgical risk calculator... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Insufficiencies Myocardial Protection The study protocol was approved by the local ethical committees. Eligible for operation were: Inclution patients with mitral regurgitation equal to or larger than grade 3 out of 4 Ablation for atrial fibrillation was the only concomitant p... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 13.0-999.0, Marfan Syndrome Male or female, aged 13 years or above at last birthday (note that there is no upper age limit for in this trial) For those aged greater than or equal to 16 years of age at the time of enrolment, participant is willing and, in the opinion of the investigator, able to ... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 30.0-80.0, Mitral Valve Stenosis With Incompetence or Regurgitation diagnosis of mitral valve insufficiency with or without coronary artery disease and a LVEF of ≤ 45 % unstable angina diabetes mellitus treated with insulin, clinical findings of acute or chronic renal failure (sCr > 1.5 mg dL-1... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Disease All patients requiring the use of an mitral anuloplasty device to restore the mitral competence by surgery are potential candidates for study if survival of at least more than 1 year is expected | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 40.0-65.0, Adult Lymphoblastic Lymphoma Disease ALL in complete remission (CR) at the time of transplant. Remission is defined as "less than 5.0% bone marrow lymphoblasts by morphology," as determined by a bone marrow aspirate obtained within 2 weeks of study registration Philadelphia chromosome... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Breast Cancer Nos Metastatic Recurrent Women Aged 18 years and over With an invasive breast cancer diagnosed by cytology or histology Tumors cT0 to cT3, CN0-3 No clinical evidence of metastasis at the time of Untreated including scored for breast cancer surgery in progress Patient re... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Thyroid Cancer Newly diagnosed with a first occurrence of thyroid cancer <2-4 weeks of diagnosis (i.e., histologically confirmed thyroid cancer (papillary, follicular, or medullary type; TNM classification system) Willing to participate in the EG meetings >18 years Alert and capable ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-65.0, Chronic Pain Women Clinical diagnosis of chronic pelvic pain More than eighteen years Non-menstrual or noncyclic pelvic pain Duration of pain of at least 6 months Duration of pain less than 6 months Women who were pregnant in the last 12 months | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Coronary Artery Stenosis Age ≥ 18 years Patient with an indication for PCI including angina (stable or unstable), silent ischemia (in absence of symptoms a visually estimated target lesion diameter stenosis of ≥70%, a positive non-invasive stress test, or FFR ≤0.80 must be present), ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Local Anaesthesia Percutaneous Repair severe mitral regurgitation PMVR using the MitraClip® system | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-50.0, Complication of Surgical Procedure Infant * prior surgical treatment for gut chest surgery (non cardiac) or non-surgical infants who will require a minimum of 2 weeks of non-oral formula/breast milk feedings may be receiving oxygen therapy and intravenous therapy may have previously be... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation severe mitral regurgitation percutaneous mitral valve repair (PMVR) with the MitraClip® system < 18 years Patients considered by the heart team to be unlikely to receive meaningful or durable clinical benefit from the procedure | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-65.0, Atrial Fibrillation Able to sign Informed Consent and Release of Medical Information forms Age ≥ 18 years Clinical indications for mitral valve surgery for organic mitral valve disease Note: May need for surgical management of functional tricuspid regurgitation or patent foramen ovale... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-75.0, Hypertrophic Obstructive Cardiomyopathy Able to sign Informed Consent and Release of Medical Information forms Age ≥ 18 years obstructive hypertrophic cardiomyopathy surgically significant mitral insufficiency II-IV (NYHA) average systolic pressure gradient greater than 50 mm Hg. Art.... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-60.0, Right Ventricular Outflow Tract Stenosis RVOT stenosis who have undergone transannular patch repair with moderate to severe pulmonary regurgitation Isotopic or CMR of and ≤160mL/m2 Age≥18 years and ≤60 years (Zhongshan Hospital age≥18 years and ≤60 years Body weight≥18 kg Pulmonary an... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Hip Osteoarthritis Leg Length Discrepancy Dislocation Any patient who is undergoing a primary total hip arthroplasty at Mount Sinai Hospital Pre-operative flexion contracture >30°, infection, or inability to achieve rigid fixation of instruments intra-operatively | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-5.0, Mitral Valve Disease Damaged Mitral Valve Malfunctioning Mitral Heart Valve Mitral Valve Replacement IDE Cohort - 1. Subject requires mitral valve replacement.* 2. Subject's legally authorized representative gives written consent to participate in the clinical study. 3. Subject is willi... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 21.0-80.0, Osteoarthritis Symptomatic osteoarthritis of the knee indicating primary total knee arthroplasty Between the ages of 21 and 80 inclusive Patients willing and able to comply with follow-up requirements and self-evaluations Ability to give informed consent Active or prior infection Med... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Thoracic Aorta Dilatation Marfan Syndrome Thoracic aorta dilatation Marfan syndrome phenotype as in the Ghent II criteria None of the inclusions criteria | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-50.0, Diabetes Mellitus Metabolic Syndrome Postpartum women with diagnosis of gestational diabetes mellitus Want to use implant contraception or nonhormonal contraceptions such as IUD or tubal sterilization Age less than 18 years old Diagnosis of diabetes mellitus at post partum period Car... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-65.0, Obesity Aged between 18 and 65 years old Morbid obesity with BMI ≥ 40 kg/m2 or BMI ≥ 35 kg/m2 associated with one or more co-morbidities (type 2 diabetes, arterial hypertension, sleep apnea, dyslipidemia, arthritis) Patient who has benefited from an upper GI endoscopy with biopsies Pa... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Nasal Valve Collapse Eligible participants are: 1. Adult patients seeking treatment for nasal obstruction on one or both sides of the nose who are willing to undergo an office-based or intraoperative nasal implant procedure in lieu of alternative treatments (ie, surgical repair or us... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-60.0, Marfan Syndrome Loeys-Dietz Syndrome Thoracic Aortic Aneurysm and Dissection Syndromes Ehlers-Danlos Type IV Syndrome Turner Syndrome To be in the study, the participant must meet the following 1. Diagnosis of hereditary aortopathy based upon Confirmation of a disease causing mutation ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Pre-Eclampsia Severe PE was defined as at least one of the following systolic pressure ≥160 mmHg or diastolic pressure ≥110 mmHg, severe proteinuria (>5 g/24 h), oliguria (<500 ml/24 h), cerebral or visual disturbances, pulmonary edema, epigastric pain, hepatic rupture, impaired live... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 60.0-999.0, Patients Waiting for Elective Isolated Coronary Artery Bypass Grafting (CABG) Patients Waiting for Aortic Valve Repair/Replacement for Moderate Aortic Stenosis or Severe Regurgitation Patients Waiting for Mitral Valve Repair/Replacement for Moderate Stenosis or Severe Regurgitation P... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Severe symptomatic mitral regurgitation (Stage D) High surgical risk for open mitral valve surgery Subject meets the anatomical for available size(s) NYHA Class III or IV heart failure DMR deemed by the heart team to be operable Prohibitive risk, deemed to... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-65.0, Morbid Obesity Subject is willing to give consent and comply with evaluation and treatment schedule 2. 18 to 65 years of age 3. Have a BMI > 30 with one or more significant co-morbid medical conditions which are generally expected to be improved, reversed, or resolved by weight loss. ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Macular Disease Patients who visit Department of Ophthalmology, Kagawa University Hospital with macular diseases, such as AMD, PCV, RAP, RVO, DME, ERM, MH, VMTS Patients who are agreed with the participation of this study None | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Severe mitral regurgitation of primary or secondary etiology 2. NYHA functional Class ≥ II. If IV, patient must be ambulatory 3. Heart team determines patient is not a suitable candidate for traditional surgical treatment 4. Age 18 years or older Severe mi... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Cataract Extraction The patient is in good general and ocular health, having a vision-reducing cataract in the intended operative eye The intended operative eye has a Snellen best corrected visual of 20/40 or worse for distance or the refraction worsens to this level with glare testi... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Failed Back Surgery Syndrome Subject is at least 18 years old 2. Subject is able and willing to comply with the follow-up schedule and protocol 3. Chronic pain following surgical lumbar discectomy for at least 6 months 4. Failed conservative treatments for chronic pain including but ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-75.0, Psoriasis Have a diagnosis of generalized chronic plaque and/or guttate psoriasis; 2. Are male and female patients aged between 18 and 75 years inclusive; 3. Have a psoriasis area and severity index (PASI) greater than 7 despite use of topical therapies; 4. Are due to undergo NB-UVB l... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 20.0-40.0, Hemorrhage of Cesarean Section and/or Perineal Wound Pregnant women aged 20-40 with singleton fetus 38 or more weeks Uncomplicated pregnancy, up to 3rd parity Women undergoing scheduled elective C.S Causes of uterine over-distention such as polyhydramnios or macrosomia Grand multi pa... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Mitral Regurgitation (1) All patients with asymptomatic chronic, severe primary degenerative MR known to the Queen Elizabeth Hospital Birmingham (of note, the aetiology and severity of MR will be based on the echocardiography findings , interpreted accordin... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Tricuspid (Valve); Deformity all patients 18 years of age or older undergoing minimally invasive, isolated mitral valve annuloplasty concomitant tricuspid valve surgery atrial fibrillation at the moment of surgery poor echocardiographic windows | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-70.0, Heart Septal Defects, Ventricular Double Outlet Right Ventricle, Noncommitted VSD Double Outlet Right Ventricle, Subaortic VSD Double Outlet Right Ventricle, Subpulmonary VSD Supracristal Ventricular Septal Defect (1) patients with single IVSD indicated by TTE，without concomitant cardi... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 22.0-999.0, Mitral Valve Disease in Native Mitral Valve arm All Candidates must meet the following 1. Patient has severe calcific native mitral valve stenosis with mitral annular calcification with echocardiographically derived mitral valve area (MVA) of ≤1.5 cm2, or severe mitral regurgitation ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Heart Valve Diseases Mitral Valve Insufficiency Heart; Dysfunction Postoperative, Cardiac Surgery Heart; Disease, Mitral(Valve) Diseases of Mitral Valve Age ≥18 years Male or female from all ethnicities At least 6 months post successful, isolated MV repair. S Asymptomatic Pulmonary ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Mitral Valve or Aortic Valve Replacement The patients who implanted with Perimount Heart Valve (Type: 6900P and 2900) during 2001-2007 in Guangdong General Hospital in China The patients agree to join the study and sign the ICF No specific | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Insufficiency Key Severe mitral regurgitation (MR Grade 3-4+) Symptomatic mitral regurgitation (NYHA Class II-IV) Trans-apical access deemed feasible by the treating physician Native mitral valve geometry and size compatible with the Twelve TMVR Key Left ventricular eje... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Mitral Valve Prolapse Mitral Valve Insufficiency All subjects referred for mitral valve surgery Presence of severe mitral regurgitation as read on an echocardiographic study performed within 60 days prior to procedure. Assessment of mitral regurgitation wil... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Hypertension, Pulmonary Diseases of Mitral Valve New York Heart Association Functional class (NYHA Fc) ≥ 2 dyspnea which was sustained till one year after the previous mitral valve surgery (repair or replacement) TR Vmax ≥ 3.5m/s by echocardiography Normal left ventricle ejection frac... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-65.0, Obesity, Severe Cesarean Section Women > 18 years old undergoing cesarean delivery 2. BMI of >/= 40 kg/m2 as determined by height and weight reported during their admission 3. Live gestation 23 weeks or greater 4. Women who are able to follow-up 7-14 days after hospital discharge for ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-90.0, Atrial Fibrillation Rheumatic Heart Disease rheumatic mitral valve lesion the absence a history of AF sinus rhythm left atrium size more than 6.0 cm refusal to participate in the study aortic stenosis / regurgitation coronary atherosclerosis | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 50.0-999.0, Aortic Valve Stenosis Age > 50 years 2. Male or female sex 3. Aortic valve area greater than 1.0 cm2 but less than 2.0 cm2 4. Aortic valve calcium levels greater than 300 AU from chest CT 5. Ejection fraction >50% Orthostatic intolerance or symptomatic hypotension prior to study or ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 6.0-80.0, Mitral Valve Prolapse MVP diagnosis Signing consent form (By parents if the patient is a minor) Other congenital or acquired cardiac problems other than MVP Patients with other diseases that can affect the exercise capacity | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Diastolic Heart Failure Diastolic Dysfunction Clinical 1. Adult (age > 18 years) 2. Diagnosis of heart failure with preserved ejection fraction 3. NYHA F. Class III or IV or documented history of at least two heart failure hospitalization in the past year prior to enrollment. 4. No c... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 25.0-90.0, Mitral Valve Insufficiency severe mitral regurgitation symptomatic (NYHA class>1) despite optimal medical therapy suitable anatomy for mitraclip implantation too high risk for cardiac surgery <1 year life expectancy | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Insufficiency Heart Valve Disease Cardiovascular Disease Heart Disease Key NYHA Classification ≥ III Left Ventricular Ejection Fraction ≥ 30% Mitral Regurgitation ≥ Grade 3+ Subject meets anatomical and for the investigational device See Protocol | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Mitral Valve or Aortic Valve Replacement The patients who implanted with Magna Ease Heart Valve (Type:7300TFX and 3300TFX) in Fuwai Hospital in China The patients agree to sign the inform consent form (ICF) No specific | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Arthroplasty, Replacement, Knee Patients requiring primary TKA, suitable for the use of the Scorpio NRG with X3 insert or Triathlon Total Knee System with X3 insert, or, patients requiring partial knee resurfacing (unicompartmental knee) suitable for the use of the Triathlon PKR (Part... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-20.0, Child Development children with their families and pregnant women of the area of Leipzig severe diseases | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-90.0, Aortic Valve Stenosis Echocardiography considered as normal and / or age-related Patients who have received prior clinical examination Patient receiving a social security scheme or entitled, or CMU After having giving written informed consent Patients symptomatic with indication of su... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Mitral Valve Prolapse Patients with mitral regurgitation and mitral valve prolapse who are scheduled for elective mitral valve repair by an experienced mitral valve repair surgeon (>15 degenerative mitral valve repairs per year, with a repair rate>90%, and able to perform mitral repai... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Hypereosinophilic Syndrome Patient having one of the three following hypereosinophilia> 1500 / mm3, checked on at least two samples (interval between 2 samples at the discretion of the clinician) or hypereosinophilia> 500 cells / mm3 and organ damage with infiltration NCB proven by p... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 65.0-99.0, Mitral Valve Insufficiency Mitral Regurgitation Prior surgery for degenerative mitral regurgitation (DMR) at Northwestern Memorial Hospital performed by a single surgeon. 2. Male and female ≥ 65 years of age at time of index procedure. 3. Mitral Valve surgery performed > 6 months and ... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 30.0-85.0, Mitral Valve Insufficiency Presence of symptomatic severe MR (effective regurgitant orifice (ERO) ≥0.2 cm2 for Secondary MR, ERO ≥0.4 cm2 for Primary MR) The New York Heart Association Functional Class II, III or ambulatory IV Left Ventricular Ejection Fraction (LVEF) is ≥20% and ≤50%... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-99.0, Pulmonary Edema >= 18 years of age urgent surgery | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mild Tricuspid Regurgitation Moderate Tricuspid Regurgitation Tricuspid Regurgitation Undergoing MVS for degenerative MR with (a) Moderate TR as determined by transthoracic 2D echocardiography, or (b) Tricuspid annular dimension ≥ 40 mm (index: ≥21mm/M2 BSA) and trace/mild TR, determ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Heart Failure Symptomatic while on optimal medical therapy (NYHA Class III-IV) Mitral regurgitation of functional etiology Suitable Mitraclip candidate Life expectancy >12 months Mitral regurgitation of primary etiology Refusal to sign the informed consent Demen... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis Severe aortic stenosis, defined as follows: 1. For symptomatic patients: Aortic valve area ≤1.0 cm2 (or aortic valve area index of ≤0.6 cm2/m2), OR mean gradient ≥40 mmHg, OR Maximal aortic valve velocity ≥4.0 m/sec by transthoracic echocardiography at rest 2. Fo... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Insufficiency Cardiac Valve Annuloplasty Mitral Valve Annuloplasty Cardiovascular Diseases Heart Diseases Heart Valve Diseases Mitral Regurgitation Age ≥18 years 2. Severe (3+ to 4+) secondary Mitral Regurgitation 3. Symptomatic heart failure (NYHA Class III-IVa) despite... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation (Degenerative or Functional) Clinically significant, symptomatic mitral regurgitation High risk for open-heart surgery Meets anatomical Unsuitable anatomy Patient is inoperable | 2 |
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