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34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Symptomatic ≥3+ degenerative or functional mitral regurgitation of either ischemic or non-ischemic etiology based by a qualifying echocardiography obtained within 90 days prior to the procedure New York Heart Association (NYHA) Functional Class III or IV Hi... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation NYHA ≥ II Moderate/severe or severe mitral regurgitation Prohibitive risk for open-heart surgery Meets anatomical Unsuitable anatomy Need for emergent or urgent surgery Prior mechanical aortic valve replacement Any prior surgical or transcatheter repair (e... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Heart Valve Diseases Aortic Valve Disease ≥ 18 years of age Severe aortic stenosis defined as aortic valve area of less than 1 cm2 or index area of 0.6 cm2/m2 or mean gradient greater than 40 mmHg by echocardiography or double lesion with predominant stenosis Re... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Metastatic Pancreatic Cancer Must have histologic or cytologic confirmation of recurrent metastatic pancreatic adenocarcinoma based on standard diagnostic criteria. Recurrence must be documented by diagnostic biopsy Have measurable disease as defined by Response Evaluation in Solid T... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis Severe aortic stenosis, defined as aortic valve area of < 1.0 cm2 (or aortic valve area index of < 0.6 cm2/m2) by the continuity equation, AND mean gradient > 40 mmHg or maximal aortic valve velocity > 4.0 m/sec by resting echocardiogram. Subjects with low-flow/l... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-80.0, Heart; Decompensation, Right Ventricle Echocardiography Hypercapnia scheduled mitral valve prolapse repair surgery able to give informed consent preoperative right ventricular dysfunction or pulmonary hypertension significant tricuspid regurgitation congenital heart defect ventricula... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 50.0-85.0, Heart Valve Diseases Coronary Artery Disease Patient indicated for first-time non-emergent procedure under cardiopulmonary bypass which is expected to last up to 6 hours. 2. Patient undergoing an elective isolated coronary artery bypass surgery (CABG), or an elective isolated aortic/m... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Has severe mitral regurgitation New York Heart Association (NYHA) Class II, III, IVa or heart failure High risk for cardiovascular surgery Excessive calcification or thickening of mitral valve annulus, severe mitral stenosis, fused commissures, valvular ve... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Mitral Valve Prolapse Mitral Valve Insufficiency Age ≥ 18 years Patient referred for mitral valve surgery Presence of severe MR as read on an echocardiographic study performed within 60 days prior to procedure Estimated post-ePTFE chordae tendineae implanta... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Mitral Valve Prolapse Mitral Valve Insufficiency All subjects referred for mitral valve surgery Presence of severe mitral regurgitation as read on an echocardiographic study performed within 60 days prior to procedure. Assessment of mitral regurgitation wil... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 21.0-999.0, Mitral Valve Insufficiency Is a candidate for mitral valve repair with cardiopulmonary bypass Has Grade III moderate or Grade IV severe degenerative mitral valve regurgitation Primary segmental prolapse of the A2 or P2 segment or prolapse extending to an adjacent segment (P1, P3, A1,... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 20.0-999.0, The Episodes of Gastric Regurgitation Patients who will receive scheduled surgery under SAD-based general anesthesia 2. Aged >= 20 Major systemic disease, such as congestive heart failure, liver cirrhosis, end stage renal disease and malignancy. 2. Patients who have the risk of diff... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 21.0-60.0, Marfan's Syndrome Patient that are under the care of the cardiologist and diagnosed with Marfan's syndrome or who had underwent Fontan palliation | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 20.0-79.0, Type B Aortic Dissection a) In case of acute Type B dissection (14 days from first dissection) Maximum aortic diameter >40 mm or Increase in aortic diameter >2 mm from baseline b) In case of subacute (15~90 days) or chronic (90 days ~ 1 year) Type B Maximum aortic diameter >55 mm or I... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Cardiovascular Diseases Severe primary mitral regurgitation (grade 3+ or 4+) Class I indication for MV Surgery according to ESC/EACTS and AHA/ACC guidelines: 1. Symptomatic patients and/or 2. LV (Left Ventricular) dysfunction : LVESD ≥45 mm and/or 30≤ LVEF ≤60% Leaflet prolapse of P2... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 22.0-999.0, Mitral Annular Calcification Subject has severe native mitral annular calcification associated with mitral stenosis and/or regurgitation. Qualifying echo must be within 60 days of the date of the procedure Subject has a clinical indication for mitral valve replacement, as demonstrate... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-15.0, Retrograde Femoral Catheterism requirement of retrograde femoral arterial catheterism none | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Prolapse Mitral valve prolapse diagnosed in echocardiography Signed written consent Affiliation to social security No contraindication to MRI or exercise ECG Age above 18 Mitral valve prolapse with severe regurgitation and instable hemodynamic state requiring urgent sur... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Bicuspid Aortic Valve bicuspid aortic valve, confirmed by transthoracic or transesophageal echocardiography With or without an aneurysm of the ascending thoracic aorta nonsyndromic aortic syndromic pathology antecedent of acute articular rhumatism | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 1.0-80.0, Data Collecting and Analyzing of Different Treatment of Structural Heart Diseases atrial septal defect 20ventricular septal defect 3.patent ductus arteriosis 4.pulmonary stenosis 5.residual leakage after surgical treatment for congenital heart disease 6.coronary artery fistula 7.pulmon... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Males or females, 18 years of age or older. 2. Negative pregnancy test (serum or urine β-HCG) within 24 hours of gadolinium contrast administration, if female and of child-bearing potential. In addition, all female patients of childbearing potential must agree to... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Disease Aged over 18 years Presenting with severe mitral valve stenosis or regurgitation regardless of etiology (primary mitral regurgitation, secondary mitral regurgitation, deterioration of mitral valve repair or bioprosthesis, mitral annular calcification) Symptomatic... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-95.0, Mitral Valve Regurgitation Organic mitral valve regurgitation with effective regurgitation orifice (ERO)>0.3 cm2 Age > 18 years Left ventricular ejection fraction (LVEF) > 60% assessed by echocardiography Signed informed consent Poor echocardiographic window Inability to perform bicy... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Tricuspid Disease Mitral Regurgitation age > 18 years ability to provide informed consent patients scheduled for mitral valve regurgitation TR ≤ 2+ with annular dilation Tricuspid diastolic diameter ≥ 40 mm or 21 mm/m2 patient's refusal non-elective cardiac surgery organic disease o... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Insufficiency Age 18 years and older Able to give informed consent Undergoing lone mitral valve surgery for chronic primary mitral regurgitation within 30 days Indication for mitral valve surgery is a class I or IIa according to the 2014 ACC/AHA guidelines for the manage... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Atrial Fibrillation Age 18+ on index date Patients must have been prescribed either dabigatran, rivaroxaban, or apixaban identified by pharmacy claim during the study period. The first dispensing date of either study drug will be defined as the index date Patients must be treatment n... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Mitral Regurgitation Ischemic cardiomyopathy Ischemic mitral regurgitation Degenerative mitral valve disease Unstable angina Recent myocardial infarction (< 6 months) Papillary muscles rupture Severe right ventricular dysfunction Multiple organ failures Concomitant left ventricular r... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Severe mitral regurgitation High surgical risk for open mitral valve surgery Subject meets anatomical Deemed too frail by objective frailty assessments Previous cardiac procedures: any mitral valve replacement surgery and cardiac transplant Unsuitable card... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Subject has provided written informed consent prior to uploading CT scan to core lab. 2. Subject is ≥ 18 years of age or legal age in host country. 3. Subject's aortic annulus diameter meets the range indicated in the Instructions for Use as measured by multisli... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Insufficiency Coronary Artery Disease Randomized patients in the MMR and SMR trials who were still alive at 2 years after the index cardiac surgical intervention Patients participating in the MMR and SMR trials who withdrew consent prior to the 2-year follow-up evaluati... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation mitral valve regurgitation transcatheter mitral valve repair no written informed consent | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Acute Myocardial Infarction Patient ≥ 18 year-old Transmural myocardial infarction in the previous 4 weeks (managed under current guideline's recommendations) Symptomatic severe mitral regurgitation diagnosed by left ventriculography, transthoracic echo or trans-... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Tricuspid (Valve) Insufficiency (Rheumatic) Patients undergoing mitral valve surgery (either repair or replacement) with less/equal than moderate (≤+2) tricuspid regurgitation and dilated tricuspid annulus (>21mm/m2 BSA) at preoperative echocardiography and fulfilling the following s... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Functional Mitral Regurgitation Heart Failure Mitral Valve Insufficiency Heart Diseases Cardiovascular Diseases Heart Valve Diseases Diagnosis of ischemic or non-ischemic cardiomyopathy 2. Symptomatic functional (secondary) mitral regurgitation defined as both (Moderate), 3+ (Moderat... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Pulmonary Hypertension symptomatic, severe mitral regurgitation referral for diagnostic work-up and heart team discussion declaration of informed consent contra-indication for cardiopulmonary stress examination (unstable angina pectoris, left main disease,... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-85.0, Mitral Regurgitation Pulmonary Hypertension Patients listed for surgery for severe primary mitral regurgitation +/ concomitant coronary artery bypass grafting for bystander disease +/ tricuspid valve surgery +/- atrial fibrillation surgery Secondary mitral regurgitation. Significant ... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 75.0-999.0, Aortic Valve Stenosis Patient with severe symptomatic aortic stenosis defined by a mean aortic gradient > 40 mmHg or peak jet velocity > 4.0 m/s or an aortic valve area (AVA) < 1cm2 or AVA indexed to body surface area (BSA) of <0.6 cm2/m2 Patient is symptomatic (heart failure with Ne... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 10.0-15.0, Children Cardiovascular Risk Factors The study was conducted in children attending 5th and 6th grade in all 20 public schools of the Municipality of Puente Alto, Santiago, Chile. All students were invited to participate in the study. Parents or their representatives signed an informed... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-90.0, Coronary Artery Disease Aortic Valve Disease Mitral Valve Disease Coronary artery bypass graft, and mitral/aortic valve replacement patients recovering from sternotomy procedure eligible for cardiac rehabilitation Able to provide written informed consent Male or female 18 years of age... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 30.0-70.0, Cardiovascular Risk Factor Metabolic Syndrome Hypertension Presence of at least one of the following formerly assessed through routine medical examination dyslipidemia, defined as the presence of either: elevated total cholesterol (>5.2 mmoL/L), and/or elevated LDL-cholesterol (>3.4 m... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation moderate to severe or severe symptomatic mitral regurgitation Local site multidisciplinary heart team experienced in mitral valve therapies agrees that the subject may not be optimally treated with approved transcatheter repair or conventional mitral valve ... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Primary Mitral Regurgitation grade 3+ or 4+ Patients in class II to IV NYHA Mitral valve anatomy appropriate to MitraClip® therapy and mitral valve surgery Adult patients judged eligible for mitral valve surgery by the local heart team but at high surgical risk d... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation severe primary mitral regurgitation due to degenerative mitral valve disease previous open cardiac surgery indication for concomitant aortic valve replacement left ventricle impairment (ejection fraction < 40%) | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Regurgitation Mitral Valve Prolapse Mitral Valve Insufficiency Age ≥ 18 years Patient referred for mitral valve surgery Presence of severe MR as read on an echocardiographic study performed within 60 days prior to procedure Estimated post-ePTFE cordal implantation coapta... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-85.0, Mitral Valve Regurgitation of Any Grade both genders age between 18 and 85 years old (adult, senior) sinus rhythm hHemodynamic stable mitral valve regurgitation (MVR) of any grade i.e., from mild to severe as determined by assessment of a qualifying TransThoracic Echocardiography (TTE... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Severe ischemic mitral valve regurgitation years of age, and able to provide informed consent Mixed mitral valve pathology Acute ischemic mitral regurgitation | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Outcomes of Trabeculectomy With MMC Fesh trabeculectomy surgeries recurrent surgeries | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Aortic Stenosis Myocardial Fibrosis Left Ventricular Hypertrophy (aortic stenosis group) Age over 18 Severe aortic stenosis with planned aortic valve replacement (control group) Age over 18 Planned non-aortic valve cardiac or elective ascending aorta surgery (aortic stenosis group) ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Mitral Valve Disease General 1. Age ≥ 18 years 2. NYHA functional II, III or ambulatory IV 3. Severe mitral regurgitation (MR grade 3-4+) 4. Subject is on optimal guideline-directed medical therapy for heart failure for at least 30 days or CRT if indicated. 5. El... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Cardiomyopathy Cardiovascular Diseases Congestive Heart Failure Coronary Artery Disease Heart Disease Valvular Heart Disease Mitral Valve Disease Patients with functional mitral regurgitation (FMR) from either ischemic or non-ischemic cardiomyopathies, referred for surgical or transc... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-75.0, Degenerative Mitral Regurgitation (MR) Due to Leaflet Prolapse Asymptomatic patients according history or an exercise test in those able to perform it if there is a doubt about the absence of symptoms Severe (grade IV) degenerative MR due to leaflet prolapse assessed by echocardiograp... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Gastroesophageal Reflux Males and non-pregnant females over the age of 18 years Gastro-oesophageal symptoms in accordance with Montreal criteria49 Patients who had oesophageal physiology testing at Guy's and St Thomas' NHS Foundation Trust Oesophageal manometry based on Chicago class... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-35.0, Failed Induction Cervical Dystocia Age (18-35) years. 2. Singleton pregnancy. 3. (37-42) weeks gestation. 4. Living fetus. 5. Cephalic presentation. 6. Absence of active labour. 7. No contraindication to vaginal delivery. 8. Average amount of clear liquor. 9. No history of uterine sca... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Mitral Insufficiency Mitral Valve Insufficiency Cardiovascular Diseases Valve Disease, Heart Heart Valve Diseases Functional Mitral Regurgitation Degenerative Mitral Valve Disease Symptomatic, moderate-to-severe or severe mitral regurgitation, or severe mitral an... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Aortopathies Thoracic Aortic Aneurysm Aortic Valve Disease Thoracic Aortic Disease Thoracic Aortic Dissection Thoracic Aortic Rupture Ascending Aortic Disease Descending Aortic Disease Ascending Aortic Aneurysm Descending Aortic Aneurysm Marfan Syndrome Loeys-Dietz Syndrome Ehlers-Dan... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 20.0-85.0, Atrial Functional Mitral Regurgitation Heart Failure NYHA(New York Heart Association) Class III and, Functional Mitral Regurgitation 3+ (Moderate/Severe) or 4+ (Severe) in spite of optimal medical treatment. (For optimal medical treatments, ①ACE inhibitor or angiotensin receptor block... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Insufficiency Left Ventricular Systolic Dysfunction Mitral Valve Prolapse functional mitral valve insufficiency with reduced mobility of leaflets during systole (type IIIb) effective regurgitation orifice area > 20 mm2 / regurgitant volume > 30 ml/beat left ventricular e... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 21.0-999.0, Heart Failure Subjects either hospitalized for decompensated systolic, diastolic, or combined heart failure or subjects presenting at an outpatient clinic with a history of hospital discharge for decompensated systolic, diastolic, or combined heart failure within the previous 10 days... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Mitral Valve Regurgitation Refer to MitraClip IFU Refer to MitraClip IFU | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-65.0, Mitral Valve Prolapse All patients that surgical for Neochord implantation with transapical mini-thoracotomy are prolapsus or chordae rupture in posterior, anterior areas or in both leaflets were included are active endocarditis, functional or ischemic mitral insufficiency (MI), exce... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 21.0-999.0, Mitral Regurgitation Patients moderate to severe, symptomatic functional (ischemic or dilated cardiomyopathies) mitral regurgitation or mitral regurgitation caused by dilation of the mitral annulus who qualify for mitral valve repair with cardiopulmonary bypass Mitral regurgitation m... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 12.0-999.0, Diet Modification Substance Use Disorders Diabetes Mellitus Risk Cardiovascular Risk Factor Lifestyle Risk Reduction Parenting Youth: ages 12-14 Youth: Enrolled in 6th,7th, or 8th grade at the time of recruitment from the American Dream Academy (ADA) programs Adults: Age 18 or older ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-90.0, Mitral Regurgitation Patients who are eligible for Mitraclip device according to current national and international guidelines (and their future revisions) and per investigator evaluation Patients who are willing and capable of providing informed consent, participating in all Follow-u... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Gestational Diabetes Women with a history of GDM in previous pregnancies Age ≥ 18 years Singleton pregnancy ≤ 16 weeks gestation • Women unable or unwilling to give consent Pre-gestational diabetes or use of anti-diabetic medication in the first visit Significant chronic medical con... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 20.0-65.0, Obesity Metabolic Syndrome Male or female patients with schizophrenia or mood disorders, followed at Taipei City Psychiatric Center will be the targeted study population. The subjects should fulfill the following 1. Age between 20 to 65 years. 2. Currently taking antipsychotics or moo... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Right Ventricular Dysfunction Rheumatic Heart Disease All ages will be accepted Isolated mitral valve lesion either stenosis or regurge Good LV function (EF <45%) Any degree of tricuspid valve regurge Concomitant Aortic valve lesion needs replacement Poor LV function (Low EF> 45%) Ot... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Heart Failure Cardiomyopathy, Dilated Study patient is at least 18-years old Severity of FMR: ≥ Moderate (i.e., ≥2+, according to Stone et al Clinical Trial Design Principles and Endpoint Definitions for Transcatheter Mitral Valve Repair and Replacement: Part 1: Clinical Trial Design... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Anastomotic Leak Colorectal Surgery Patients submitted to laparoscopic/robotic/open/converted ileo-colo-rectal resection with anastomosis (both intra and/or extra-corporeal), including planned Hartmann's reversals. 2. American Society of Anesthesiologists' (ASA) class I, II or III 3. ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Diabetic Retinopathy Patients with diabetes mellitus type 2 with and without diabetic retinopathy who needs cataract surgery Patients who need cataract surgery without any intravitreal injections Absence of any ocular disease other than diabetes mellitus Cataract density allowing goo... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 5.0-19.0, Marfan Syndrome 19 years of age (patient) seen in at least 2 prior clinic visits Marfan syndrome by revised Ghent presence of parent at home prior aortic surgery known cardiomyopathy known arrhythmia aortic root > 4.5 cm in prior clinic visit pregnancy | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Mitral Regurgitation Patient has undergone percutaneous mitral valve repair with MitraClip Clip Delivery System in Canada none | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-80.0, Mitral Valve Prolapse Mitral Regurgitation Mitral Valve Disease Patients undergo mitral valve repair with either surgery of MitraClip techniques Over 18 years old Unable to place TEE probe Refuse consent | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Subject has documented severe aortic stenosis defined as initial AVA ≤1.0 cm2 (or AVA index ≤0.6 cm2/m2) AND a mean pressure gradient ≥40 mm Hg OR maximal aortic valve velocity ≥4.0 m/s OR Doppler velocity index ≤0.25 as measured by echocardiography and/or invas... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-45.0, Infertility Patients initiating an autologous IVF cycle 2. Patient age 18-45; partner age 18-60 3. Partner planning to provide fresh semen sample on day of oocyte retrieval 4. Patients planning to undergo preimplantation genetic screening (PGS) of embryos with single embryo transfer (... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-44.0, Gestational Diabetes Study group women between 24 weeks' gestation who were diagnosed with gestational diabetes mellitus or known with type I or type II diabetes mellitus. Control group women between 24 weeks' gestation who do not have diabetes women who did not complete a glucose ch... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Mitral Valve Disease Mitral Valve Failure Mitral Disease Valve Heart Disease Valve Disease, Heart Has severe mitral regurgitation New York Heart Association (NYHA) Class II, III, IVa or heart failure High risk for cardiovascular surgery Excessive calcification o... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Valvular Heart Disease (Aortic and Mitral Valves) Patients with clinically diagnosed valvular heart disease and confirmed by echocardiography Patients with known contraindication to MRI including the presence of paramagnetic Surgical clips, or pacemakers Severely ill patients Claustr... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Degenerative Mitral Valve Disease Isolated type II mitral valve insufficiency by A. Carpentier 2. Mitral regurgitation degree >2 3. Age >18 years 4. Signed informed consent to participate in the study Any other cardiac surgeries 2. Age <18 years 3. Multiple organ failure 4. ReDo pro... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Myocardial Function of the Stenosis Aortic Valve Before and Beyond Valve Replacement major patient freely accepting to participate in the study non-opposition signed aortic surface <1cm² or <0.6cm² / m² of indication surgical restraint oriented to short interventional management surg... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Degenerative Mitral Valve Disease Mitral Regurgitation Mitral Insufficiency Functional Mitral Regurgitation Eighteen (18) years of age or older Patient is able and willing to give informed consent and follow protocol procedures, and comply with follow-up visit requirements Patient is... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation General 2. NYHA functional II, III or ambulatory IV 3. Severe mitral regurgitation (MR grade 3-4+) with pronounced secondary MR etiology 4. Subject is on optimal guideline-directed medical therapy for heart failure for at least 30 days or CRT if indicated. 5. Ele... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Cystocele Vaginal Vault Prolapse Rectocele Enterocele Symptomatic prolapse stage >1 (cystocele, vaginal vault prolapse, enterocele, rectocele) according to POP-Q System Negative Pap-smear Asymptomatic prolapse prolapse stage <=1 prolapse of uterus presence of any type of genital infe... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 21.0-99.0, Dry Eye Patients with dry eye symptoms, who cannot be satisfactorily managed by currently available dry eye medication 2. TBUT ≤10s 3. Presence of corneal fluorescein staining 4. Visual acuity affected by poor tear film quality 5. No contraindication for blood extraction/ plasmapheres... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 5.0-15.0, Metabolic Syndrome Cancer survivors Treatment with chemotherapy and/or radiation therapy for a primary ALL/NHL diagnosed prior to age 17 years ≤ 15 years of age at the time of enrollment No cytostatic drugs uptake during the study Diagnosis of diabetes mellitus types 1 or 2 types befo... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-84.0, Mitral Regurgitation Age ≥ 18 years Symptomatic (Stage D) severe MR confirmed by the echo core lab Cardiac Index > 2.0 Left Ventricular Ejection Fraction (LVEF) is ≥ 30% (within 90 days prior to subject enrollment based upon TTE) New York Heart Association (NYHA) Functional Class II, ... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-85.0, Gastroesophageal Reflux Disease Patients submitted to primary minimally invasive surgery for gastroesophageal reflux diseases or hiatus hernia Age > 18 years Patients already submitted to minimally invasive surgery for gastroesophageal reflux diseases or hiatus hernia for recurrence ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 15.0-50.0, Hypertension, Pregnancy-Induced Hypertension, Essential Hypertension Hypertension; Pre-Eclampsia Hypertension in Pregnancy High risk pregnancy At 12-16 weeks of gestation Aged between 15 to 50 years Living in Matlab bangladesh Have congenital malformation/anomaly in current pregnancy... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-71.0, Revisions After MGB/OAGB Morbidities Morality They have a BMI of 40 kg/m2 or more, or between 35 kg/m2 and 40 kg/m2 and other significant disease (for example, type 2 diabetes or high blood pressure) that could be improved if they lost weight. 2. All appropriate non-surgical measures ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 20.0-40.0, Long QT Syndrome Hypoglycemia Healthy men and women Age ≥20 and ≤40 years BMI ≥18,5 and ≤27,5 Chronic diseases (cardiac, metabolic, liver) including a family history of congenital Long QT syndrome QTc values >440 ms (men) and >450 ms (women) Clinical important and/or symptomatic brad... | 1 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-75.0, Advanced Solid Tumors Males and/or females age from 18 to 75; 2. Histologically or cytologically confirmed patients with advanced malignant solid tumors, eligible patients must have failed standard treatment, no standard treatment, or not suitable for standard treatment at this stage ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 0.0-999.0, Mitral Valve Prolapse Genetic Disease Patients of any age with typical mitral valve prolapse relatives examined during familial screening Refusal of the patient | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-75.0, Mitral Valve Replacement Transfusion Reaction Blood Transfusion Complication Patients undergoing "mitral valve replacement" surgery; 2. Age 18-75 years old; 3. 48h biochemical indicators before surgery, blood general indicators, coagulation indicators are complete Lack of necessary t... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 21.0-999.0, Mitral Valve Regurgitation Patients must meet ALL the following : 1. with primary or secondary mitral regurgitation recorded by TTE and confirmed during TEE where surgery for mitral valve repair is required with indications consistent with AHA/ACC and ESC/EACTS guidelines : 1. primar... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 1.0-99.0, Malaria FOR 1,2,3: All of the following must be fulfilled for a volunteer to participate in this trial: 1. Meets age requirements for Arm currently being enrolled. 2. Available for the duration of the trial. 3. Family compound known resident or long-term resident (more than 1 year) of ... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Tricuspid Regurgitation Age > 18 years 2. Indication left-side valve surgery Unwillingness to give informed consent and to enter a regular follow-up program. 2. Prior surgical or percutaneous mitral valve intervention 3. Contraindication to cardiopulmonary bypass (CPB) 4. Clinical s... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Regurgitation Age ≥ 18 years NYHA functional II, III or ambulatory IV Severe mitral regurgitation (MR grade 3-4+) High risk for conventional open mitral valve repair or replacement surgery in the consideration of the site Heart Team (including a cardiac surgeon, a cardiologist... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Mitral Valve Insufficiency Any patient with primary mitral insufficiency by prolapse (any grade) diagnosed by Trans-Thoracic Echocardiography (TTE) From November 2010 to April 2019 (retrospective cohort) From May 2019 to May 2024 (prospective cohort) No previous surgery of the mitral... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Severe Mitral Regurgitation Preserved Ventricular Ejection Fraction Stage 3 or 4, primary and chronic mitral regurgitation, going for a planned surgery, with pre-operative left ventricular ejection fraction > 60% and left ventricular end-systolic dimension < 45mm Able to consent With... | 2 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-999.0, Acute Ischaemic Stroke Patients aged 18 and older at onset of an acute ischaemic stroke Availability of at least one pre-therapeutic MRI performed in our centre within 12 h of stroke onset, including a post-contrast 3D TSE T1-weighted sequence Patients with posterior fossa strokes P... | 0 |
34 year old woman with Marfan's syndrome and known severe mitral valve prolapse with regurgitation, who was planned for a MV repair but was lost to follow-up. She remains symptomatic and is now prepared to undergo mitral valve repair/replacement surgery. EF of 65% on TTE. Past Medical History: Marfans Syndrome MVP with... | eligible ages (years): 18.0-75.0, Mitral Regurgitation 75 years Asymptomatic patients. "Asymptomatic" is defined as absence of subjective limitations of exercise capacity or complaints expressed by the patient and confirmed by the treating cardiologist Severe organic mitral valve regurgitation. "Severe organic mitral ... | 0 |
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