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siditom
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AMELI_PAIR_DB

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E3_UniProtID
string
Sub_UniProtID
string
Reference
string
Source
string
E3_Gene_Name
string
E3_Sequence
string
E3_Species
string
E3_Subcellular_Location
string
E3_HPA_Expression
string
E3_scRNA_Data
string
E3_PDB_IDs
string
E3_GTEx_expression
string
Sub_Gene_Name
string
Sub_Sequence
string
Sub_Species
string
Sub_Subcellular_Location
string
Sub_HPA_Expression
string
Sub_scRNA_Data
string
Sub_PDB_IDs
string
Sub_GTEx_expression
string
E3_Confidence_Scores
string
E3_Relative_SASA
string
Sub_Confidence_Scores
string
Sub_Relative_SASA
string
E3_Type
string
E3_Complex
string
Complex_name
string
Susbtrate_specificity
string
E3_Known_direct_interactions
string
E3_Substrates
string
PolyUb_Lys
string
C/N_end
string
Associated_E2
string
Self_oligomerization
string
Atypical_AA_ubi
string
E3_Confidence_Scores_Avg
float64
E3_Relative_SASA_Avg
float64
Sub_Confidence_Scores_Avg
float64
Sub_Relative_SASA_Avg
float64
ClusterID
int64
O60260
O96020
12628165
UbiNet, UbiBrowser
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
CCNE2
MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAALCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTHTNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH
Homo sapiens
Nucleus
Tissue enhanced (bone marrow, brain)
{'Ciliated cells': '0.7', 'Basal respiratory cells': '2.2', 'Club cells': '1.3', 'Ionocytes': '0.4', 'Mucus glandular cells': '1.2', 'Serous glandular cells': '0.7', 'Gastric mucus-secreting cells': '4.1', 'Proximal enterocytes': '5.0', 'Paneth cells': '2.7', 'Distal enterocytes': '5.6', 'Intestinal goblet cells': '4.7', 'Exocrine glandular cells': '-0.668', 'Basal prostatic cells': '1.1', 'Prostatic glandular cells': '1.7', 'Breast glandular cells': '0.364', 'Breast myoepithelial cells': '0.194', 'Glandular and luminal cells': '2.4', 'Secretory cells': '0.3', 'Basal keratinocytes': '4.7', 'Suprabasal keratinocytes': '4.7', 'Basal squamous epithelial cells': '8.0', 'Squamous epithelial cells': '7.9', 'Alveolar cells type 1': '-0.051', 'Alveolar cells type 2': '-0.178', 'Salivary duct cells': '1.9', 'Ductal cells': '0.540', 'Hepatocytes': '0.141', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.182', 'Distal tubular cells': '0.0', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.000', 'Sertoli cells': '-0.008', 'Granulosa cells': '3.1', 'Enteroendocrine cells': '1.4', 'Pancreatic endocrine cells': '3.4', 'Leydig cells': '-0.050', 'Excitatory neurons': '2.2', 'Inhibitory neurons': '2.5', 'Cone photoreceptor cells': '3.4', 'Rod photoreceptor cells': '4.8', 'Bipolar cells': '3.7', 'Horizontal cells': '5.7', 'Astrocytes': '0.6', 'Oligodendrocyte precursor cells': '1.4', 'Oligodendrocytes': '32.1', 'Microglial cells': '0.0', 'Muller glia cells': '0.5', 'Schwann cells': '0.136', 'Spermatogonia': '0.359', 'Spermatocytes': '0.828', 'Early spermatids': '0.462', 'Late spermatids': '0.051', 'Oocytes': '0.0', 'Cytotrophoblasts': '7.6', 'Syncytiotrophoblasts': '2.1', 'Extravillous trophoblasts': '6.8', 'Endothelial cells': '3.6', 'Lymphatic endothelial cells': '2.6', 'Cardiomyocytes': '0.426', 'Skeletal myocytes': '-0.135', 'Smooth muscle cells': '2.4', 'Adipocytes': '5.6', 'Melanocytes': '0.260', 'Fibroblasts': '2.0', 'Peritubular cells': '-0.036', 'Endometrial stromal cells': '2.1', 'Ovarian stromal cells': '0.6', 'Undifferentiated cells': '6.8', 'T-cells': '6.2', 'B-cells': '2.3', 'Plasma cells': '13.9', 'Nk-cells': '3.3', 'Granulocytes': '0.6', 'Monocytes': '5.0', 'Macrophages': '4.9', 'Hofbauer cells': '3.3', 'Kupffer cells': '2.2', 'Dendritic cells': '0.8', 'Langerhans cells': '0.266', 'Erythroid cells': '0.022', 'Adipocytes (Subcutaneous)': '-0.088', 'Adipocytes (Visceral)': '-0.256', 'Breast glandular cells (progenitors)': '0.180', 'Adipocytes (Breast)': '-0.303', 'Colon enterocytes': '0.167', 'Colon enteroendocrine cells': '-0.027', 'Enteric glia cells': '-0.038', 'Mitotic cells (Colon)': '0.206', 'Mitotic cells (Heart)': '0.485', 'Podocytes': '-0.092', 'Ascending Loop of Henle cells': '0.275', 'Intercalated cells': '-0.058', 'Cholangiocyte': '0.253', 'NK-cells (Liver)': '-0.095', 'Respiratory ciliated cells': '0.060', 'Mitotic cells (Lung)': '0.310', 'NK-cells (Lung)': '0.190', 'B-cells (Lung)': '0.114', 'Alpha cells': '0.280', 'Beta cells': '0.158', 'Prostate glandular cells': '-0.145', 'Prostate basal glandular cells': '0.314', 'Urothelial cells': '0.364', 'Keratinocyte (other)': '0.212', 'Keratinocyte (granular)': '-0.132', 'Hair cortex cells': '-0.003', 'Inner root sheath cells': '0.087', 'Outer root sheath cells': '0.187', 'Sebaceous gland cells': '0.160', 'Eccrine sweat gland cells': '-0.083', 'Adipocytes (Skin)': '-0.060', 'Mitotic cells (Skin)': '0.471', 'Parietal cells': '0.210', 'Chief cells': '0.333', 'Gastric mucous cells': '0.378', 'Gastric enteroendocrine cells': '0.377', 'Mitotic cells (Stomach)': '0.405', 'Parafollicular cells': '-0.023', 'Thyroid glandular cells': '-0.026', 'Mitotic cells (Thyroid)': '0.177', 'Adrenal cortex cells': '0.052', 'Adrenal medulla cells': '0.072', 'Mitotic cells (Adrenal gland)': '0.479', 'Minor salivary glandular cells': '0.198', 'Minor salivary gland ductal cells': '-0.142', 'Minor salivary gland basal cells': '0.633', 'Mitotic cells (Minor salivary gland)': '0.688', 'Adipocytes (Minor salivary gland)': '0.126', 'Somatotropes': '0.078', 'Lactotropes': '0.034', 'Gonadotropes': '0.048', 'Corticotropes': '0.095', 'Thyrotropes': '0.095', 'Undifferentiated cells (Pituitary gland)': '-0.063', 'Mitotic cells (Spleen)': '0.335', 'Platelets': '-0.133', 'Erythrocytes': '0.092', 'Hematopoietic stem cells': '-0.064', 'B-cells (Spleen)': '0.132', 'NK-cells (Spleen)': '0.122', 'Amygdala excitatory': '3.2', 'Cerebellar inhibitory': '7.4', 'Cge interneuron': '5.7', 'Deep-layer corticothalamic and 6b': '2.7', 'Deep-layer intratelencephalic': '3.3', 'Deep-layer near-projecting': '5.8', 'Eccentric medium spiny neuron': '5.1', 'Hippocampal ca1-3': '3.1', 'Hippocampal ca4': '3.9', 'Hippocampal dentate gyrus': '7.5', 'Lamp5-lhx6 and chandelier': '4.5', 'Lower rhombic lip': '6.4', 'Mammillary body': '10.0', 'Medium spiny neuron': '4.9', 'Mge interneuron': '4.8', 'Midbrain-derived inhibitory': '5.5', 'Miscellaneous': '2.8', 'Splatter': '6.0', 'Thalamic excitatory': '4.8', 'Upper rhombic lip': '9.5', 'Upper-layer intratelencephalic': '4.5', 'Astrocyte': '2.7', 'Bergmann glia': '3.0', 'Central nervous system macrophage': '2.5', 'Choroid plexus epithelial cell': '6.6', 'Committed oligodendrocyte precursor': '23.4', 'Ependymal cell': '2.2', 'Oligodendrocyte': '49.8', 'Oligodendrocyte precursor cell': '8.0', 'Endothelial cell': '2.6', 'Pericyte': '4.3', 'Vascular associated smooth muscle cell': '1.2', 'Fibroblast': '3.2', 'Leukocyte': '4.2', 'Basophil': '2.3', 'Eosinophil': '0.1', 'Neutrophil': '2.6', 'Classical monocyte': '1.3', 'Non-classical monocyte': '1.6', 'Intermediate monocyte': '0.5', 'T-reg': '9.4', 'GdT-cell': '0.8', 'MAIT T-cell': '0.9', 'Memory CD4 T-cell': '1.1', 'Naive CD4 T-cell': '5.0', 'Memory CD8 T-cell': '1.3', 'Naive CD8 T-cell': '3.7', 'Memory B-cell': '0.3', 'Naive B-cell': '4.3', 'Plasmacytoid DC': '0.6', 'Myeloid DC': '0.5', 'NK-cell': '3.3', 'Total PBMC': '3.2', 'Vd2 gdTCR': '4.3', 'Memory CD4 T-cell Th1\\/Th17': '3.7', 'Memory CD4 T-cell Th17': '3.9', 'Memory CD4 T-cell Th2': '4.8', 'Non-Vd2 gdTCR': '2.3', 'Memory CD4 T-cell Th1': '3.4', 'Memory CD4 T-cell TFH': '3.3', 'Terminal effector memory CD4 T-cell': '5.7', 'Central memory CD8 T-cell': '3.7', 'Effector memory CD8 T-cell': '9.0', 'Terminal effector memory CD8 T-cell': '6.7', 'Non-switched memory B-cell': '1.0', 'Plasmablast': '16.6', 'Switched memory B-cell': '1.4', 'Exhausted memory B-cell': '4.8', 'Progenitor cell': '5.4', 'Memory T-reg': '5.3', 'Naive CD4 T-cell activated': '1.3', 'Naive CD8 T-cell activated': '0.9', 'Naive T-reg': '6.0'}
8HN9
{'Adipose Tissue': 1.1964255813953488, 'Adrenal Gland': 0.6601131550387597, 'Bladder': 1.2086238095238095, 'Blood': 1.5119590635091495, 'Blood Vessel': 0.8560257752808988, 'Brain': 2.5396083724451173, 'Breast': 1.0775217864923747, 'Cervix Uteri': 2.529842105263158, 'Colon': 1.471318485237484, 'Esophagus': 1.8664956401384083, 'Fallopian Tube': 1.2943222222222224, 'Heart': 0.4022545296167247, 'Kidney': 0.5598865168539326, 'Liver': 0.52388, 'Lung': 2.024080795847751, 'Muscle': 0.3246810709838107, 'Nerve': 1.4850854604200323, 'Ovary': 1.722728888888889, 'Pancreas': 0.9261698170731708, 'Pituitary': 1.1781925795053003, 'Prostate': 1.5638497959183673, 'Salivary Gland': 1.4026746913580246, 'Skin': 2.7663494195688227, 'Small Intestine': 2.0915090909090908, 'Spleen': 1.9683709543568464, 'Stomach': 1.4714626740947074, 'Testis': 8.977138504155125, 'Thyroid': 1.528176875957121, 'Uterus': 1.645343661971831, 'Vagina': 2.4700858974358972}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
77.4725
0.481238
1,939
O60260
P00387
33082525, 23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
CYB5R3
MGAQLSTLGHMVLFPVWFLYSLLMKLFQRSTPAITLESPDIKYPLRLIDREIISHDTRRFRFALPSPQHILGLPVGQHIYLSARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDTHPKFPAGGKMSQYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAGGTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSARFKLWYTLDRAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDHVGHPTERCFVF
Homo sapiens
Endoplasmic reticulum membrane, Mitochondrion outer membrane, Cytoplasm
Low tissue specificity
{'Ciliated cells': '62.9', 'Basal respiratory cells': '180.5', 'Club cells': '96.1', 'Ionocytes': '121.9', 'Mucus glandular cells': '60.9', 'Serous glandular cells': '40.7', 'Gastric mucus-secreting cells': '35.4', 'Proximal enterocytes': '121.0', 'Paneth cells': '75.8', 'Distal enterocytes': '86.2', 'Intestinal goblet cells': '41.6', 'Exocrine glandular cells': '-0.687', 'Basal prostatic cells': '204.5', 'Prostatic glandular cells': '68.9', 'Breast glandular cells': '-0.453', 'Breast myoepithelial cells': '-0.312', 'Glandular and luminal cells': '69.9', 'Secretory cells': '73.1', 'Basal keratinocytes': '96.2', 'Suprabasal keratinocytes': '114.3', 'Basal squamous epithelial cells': '39.9', 'Squamous epithelial cells': '59.7', 'Alveolar cells type 1': '0.131', 'Alveolar cells type 2': '-0.229', 'Salivary duct cells': '81.9', 'Ductal cells': '0.691', 'Hepatocytes': '0.501', 'Cholangiocytes': '112.6', 'Proximal tubular cells': '0.247', 'Distal tubular cells': '36.9', 'Collecting duct cells': '62.2', 'Mesothelial cells': '0.087', 'Sertoli cells': '0.762', 'Granulosa cells': '84.6', 'Enteroendocrine cells': '81.2', 'Pancreatic endocrine cells': '176.6', 'Leydig cells': '0.746', 'Excitatory neurons': '11.8', 'Inhibitory neurons': '15.4', 'Cone photoreceptor cells': '11.9', 'Rod photoreceptor cells': '15.1', 'Bipolar cells': '17.5', 'Horizontal cells': '21.4', 'Astrocytes': '16.1', 'Oligodendrocyte precursor cells': '6.6', 'Oligodendrocytes': '24.5', 'Microglial cells': '24.2', 'Muller glia cells': '100.6', 'Schwann cells': '0.153', 'Spermatogonia': '0.554', 'Spermatocytes': '0.057', 'Early spermatids': '-0.559', 'Late spermatids': '-0.702', 'Oocytes': '74.3', 'Cytotrophoblasts': '111.0', 'Syncytiotrophoblasts': '121.1', 'Extravillous trophoblasts': '226.4', 'Endothelial cells': '188.3', 'Lymphatic endothelial cells': '275.8', 'Cardiomyocytes': '0.634', 'Skeletal myocytes': '-0.118', 'Smooth muscle cells': '256.8', 'Adipocytes': '226.2', 'Melanocytes': '0.103', 'Fibroblasts': '205.0', 'Peritubular cells': '0.559', 'Endometrial stromal cells': '83.8', 'Ovarian stromal cells': '124.0', 'Undifferentiated cells': '53.7', 'T-cells': '43.5', 'B-cells': '64.0', 'Plasma cells': '46.3', 'Nk-cells': '35.3', 'Granulocytes': '55.3', 'Monocytes': '87.4', 'Macrophages': '65.6', 'Hofbauer cells': '100.7', 'Kupffer cells': '76.9', 'Dendritic cells': '42.2', 'Langerhans cells': '0.232', 'Erythroid cells': '-0.046', 'Adipocytes (Subcutaneous)': '0.384', 'Adipocytes (Visceral)': '0.290', 'Breast glandular cells (progenitors)': '-0.379', 'Adipocytes (Breast)': '0.630', 'Colon enterocytes': '-0.208', 'Colon enteroendocrine cells': '0.283', 'Enteric glia cells': '0.310', 'Mitotic cells (Colon)': '0.015', 'Mitotic cells (Heart)': '0.564', 'Podocytes': '-0.044', 'Ascending Loop of Henle cells': '0.380', 'Intercalated cells': '-0.023', 'Cholangiocyte': '0.344', 'NK-cells (Liver)': '-0.466', 'Respiratory ciliated cells': '-0.021', 'Mitotic cells (Lung)': '-0.032', 'NK-cells (Lung)': '-0.005', 'B-cells (Lung)': '-0.069', 'Alpha cells': '0.483', 'Beta cells': '0.278', 'Prostate glandular cells': '-0.386', 'Prostate basal glandular cells': '-0.215', 'Urothelial cells': '-0.099', 'Keratinocyte (other)': '0.045', 'Keratinocyte (granular)': '-0.027', 'Hair cortex cells': '0.025', 'Inner root sheath cells': '-0.009', 'Outer root sheath cells': '0.101', 'Sebaceous gland cells': '-0.013', 'Eccrine sweat gland cells': '0.078', 'Adipocytes (Skin)': '0.089', 'Mitotic cells (Skin)': '-0.016', 'Parietal cells': '-0.672', 'Chief cells': '-0.499', 'Gastric mucous cells': '-0.562', 'Gastric enteroendocrine cells': '-0.411', 'Mitotic cells (Stomach)': '-0.116', 'Parafollicular cells': '0.049', 'Thyroid glandular cells': '0.206', 'Mitotic cells (Thyroid)': '0.067', 'Adrenal cortex cells': '0.711', 'Adrenal medulla cells': '0.202', 'Mitotic cells (Adrenal gland)': '0.421', 'Minor salivary glandular cells': '0.267', 'Minor salivary gland ductal cells': '0.092', 'Minor salivary gland basal cells': '0.427', 'Mitotic cells (Minor salivary gland)': '0.425', 'Adipocytes (Minor salivary gland)': '0.382', 'Somatotropes': '-0.313', 'Lactotropes': '-0.129', 'Gonadotropes': '0.028', 'Corticotropes': '0.252', 'Thyrotropes': '0.312', 'Undifferentiated cells (Pituitary gland)': '0.214', 'Mitotic cells (Spleen)': '-0.400', 'Platelets': '-0.085', 'Erythrocytes': '-0.111', 'Hematopoietic stem cells': '-0.132', 'B-cells (Spleen)': '0.021', 'NK-cells (Spleen)': '0.063', 'Amygdala excitatory': '22.2', 'Cerebellar inhibitory': '32.1', 'Cge interneuron': '30.5', 'Deep-layer corticothalamic and 6b': '24.9', 'Deep-layer intratelencephalic': '23.0', 'Deep-layer near-projecting': '33.5', 'Eccentric medium spiny neuron': '22.0', 'Hippocampal ca1-3': '19.9', 'Hippocampal ca4': '19.4', 'Hippocampal dentate gyrus': '18.1', 'Lamp5-lhx6 and chandelier': '31.3', 'Lower rhombic lip': '35.0', 'Mammillary body': '23.2', 'Medium spiny neuron': '19.0', 'Mge interneuron': '24.6', 'Midbrain-derived inhibitory': '21.1', 'Miscellaneous': '21.0', 'Splatter': '31.8', 'Thalamic excitatory': '23.5', 'Upper rhombic lip': '24.8', 'Upper-layer intratelencephalic': '19.5', 'Astrocyte': '28.7', 'Bergmann glia': '30.1', 'Central nervous system macrophage': '21.5', 'Choroid plexus epithelial cell': '18.3', 'Committed oligodendrocyte precursor': '36.4', 'Ependymal cell': '40.2', 'Oligodendrocyte': '51.8', 'Oligodendrocyte precursor cell': '31.4', 'Endothelial cell': '121.7', 'Pericyte': '191.9', 'Vascular associated smooth muscle cell': '147.5', 'Fibroblast': '61.7', 'Leukocyte': '33.7', 'Basophil': '105.5', 'Eosinophil': '296.0', 'Neutrophil': '108.1', 'Classical monocyte': '38.6', 'Non-classical monocyte': '39.7', 'Intermediate monocyte': '150.2', 'T-reg': '50.3', 'GdT-cell': '73.1', 'MAIT T-cell': '72.5', 'Memory CD4 T-cell': '69.5', 'Naive CD4 T-cell': '13.1', 'Memory CD8 T-cell': '81.3', 'Naive CD8 T-cell': '15.9', 'Memory B-cell': '101.1', 'Naive B-cell': '21.5', 'Plasmacytoid DC': '183.1', 'Myeloid DC': '221.3', 'NK-cell': '33.1', 'Total PBMC': '135.0', 'Vd2 gdTCR': '61.5', 'Memory CD4 T-cell TFH': '36.1', 'Memory CD4 T-cell Th2': '26.7', 'Memory CD4 T-cell Th17': '26.7', 'Memory CD4 T-cell Th1\\/Th17': '18.6', 'Non-Vd2 gdTCR': '69.9', 'Memory CD4 T-cell Th1': '28.1', 'Terminal effector memory CD4 T-cell': '79.8', 'Central memory CD8 T-cell': '48.2', 'Effector memory CD8 T-cell': '79.5', 'Terminal effector memory CD8 T-cell': '76.6', 'Switched memory B-cell': '136.0', 'Plasmablast': '91.8', 'Non-switched memory B-cell': '186.8', 'Exhausted memory B-cell': '134.0', 'Progenitor cell': '129.4', 'Naive CD4 T-cell activated': '16.8', 'Naive CD8 T-cell activated': '19.2', 'Memory T-reg': '39.5', 'Naive T-reg': '18.9'}
1UMK, 7THG, 7TNV, 7TSW, 7W3O
{'Adipose Tissue': 342.4728405315615, 'Adrenal Gland': 239.28953488372093, 'Bladder': 236.8571428571429, 'Blood': 60.165411194833155, 'Blood Vessel': 633.6901123595507, 'Brain': 79.55132475397427, 'Breast': 267.4728976034858, 'Cervix Uteri': 296.12105263157895, 'Colon': 168.11706033376123, 'Esophagus': 197.94473356401383, 'Fallopian Tube': 221.84444444444443, 'Heart': 150.08017421602787, 'Kidney': 115.8561797752809, 'Liver': 113.02353982300885, 'Lung': 234.77006920415224, 'Muscle': 88.39433374844333, 'Nerve': 277.86510500807753, 'Ovary': 259.8855555555556, 'Pancreas': 35.061189024390245, 'Pituitary': 149.19445229681978, 'Prostate': 203.0671020408163, 'Salivary Gland': 130.9862962962963, 'Skin': 241.49233278054177, 'Small Intestine': 129.0434759358289, 'Spleen': 99.71244813278008, 'Stomach': 142.6635097493036, 'Testis': 183.9140997229917, 'Thyroid': 199.42643185298624, 'Uterus': 276.55774647887324, 'Vagina': 243.94961538461536}
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[46.4, 43.38, 49.12, 52.21, 49.04, 54.69, 54.39, 49.39, 48.99, 51.11, 52.42, 56.07, 59.35, 70.43, 76.38, 78.67, 79.05, 83.23, 80.54, 80.95, 77.57, 78.09, 76.19, 73.0, 64.0, 63.75, 60.66, 55.42, 58.57, 70.14, 85.83, 93.05, 96.91, 97.92, 98.51, 98.06, 96.74, 96.01, 95.45, 95.49, 97.61, 98.02, 98.52, 98.5, 98.82, 98.77, 98.89, 98.71, 98.71, 98.37, 97.34, 95.5, 90.51, 87.37, 90.09, 93.47, 93.27, 96.69, 97.64, 98.71, 98.85, 98.91, 98.85, 98.85, 98.45, 98.2, 97.78, 97.57, 98.43, 98.51, 98.62, 98.28, 98.53, 98.23, 98.61, 98.05, 98.57, 98.67, 98.77, 98.72, 98.76, 98.47, 98.08, 97.54, 96.95, 94.65, 95.28, 97.02, 97.88, 98.4, 98.28, 98.32, 98.29, 98.56, 98.6, 98.5, 97.12, 97.68, 97.7, 97.72, 96.43, 97.92, 98.15, 98.48, 98.83, 98.86, 98.67, 98.52, 97.04, 96.49, 95.31, 96.99, 95.84, 97.35, 97.31, 96.3, 92.97, 89.69, 91.67, 92.13, 93.48, 96.2, 97.14, 97.01, 96.87, 98.17, 98.5, 98.12, 98.56, 98.55, 98.48, 98.31, 98.17, 98.48, 98.5, 98.69, 98.61, 98.59, 98.63, 98.76, 98.67, 98.78, 98.37, 97.79, 97.84, 97.65, 97.66, 98.28, 98.59, 98.71, 98.8, 98.56, 98.48, 98.5, 98.54, 98.77, 98.79, 98.62, 98.45, 97.73, 96.04, 96.19, 93.72, 95.21, 96.82, 97.3, 97.68, 97.79, 98.31, 97.35, 98.45, 98.62, 98.68, 98.76, 98.91, 98.92, 98.95, 98.92, 98.84, 98.11, 94.66, 94.15, 97.25, 98.2, 98.17, 98.55, 98.73, 98.43, 98.54, 98.77, 98.78, 98.41, 98.49, 98.64, 98.43, 97.21, 98.25, 97.78, 98.39, 98.63, 98.53, 98.83, 98.89, 98.93, 98.93, 98.93, 98.92, 98.82, 98.72, 97.17, 94.26, 94.62, 95.63, 92.34, 92.04, 95.48, 94.32, 94.6, 96.17, 95.11, 95.1, 98.3, 98.22, 98.07, 98.25, 98.38, 98.13, 98.16, 98.34, 97.81, 98.32, 98.56, 98.86, 98.82, 98.84, 98.83, 98.84, 98.78, 98.44, 97.01, 96.75, 96.69, 97.2, 95.61, 96.77, 97.91, 97.14, 98.36, 97.89, 98.18, 97.76, 98.05, 98.67, 98.63, 98.57, 98.56, 98.73, 98.82, 98.67, 98.61, 98.75, 98.75, 98.62, 98.48, 98.33, 97.94, 98.01, 98.19, 98.65, 98.72, 98.87, 98.9, 98.83, 98.67, 97.89, 95.91, 96.97, 97.09, 98.37, 98.54, 98.21, 98.08, 98.39, 98.67, 98.46, 98.4, 98.71, 98.72, 98.3, 98.25, 98.45, 98.44, 98.47, 97.15, 95.06, 95.23, 96.74, 98.24, 98.49, 98.16, 97.91]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
94.126877
0.353223
2,251
O60260
P00558
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PGK1
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI
Homo sapiens
Cytoplasm
Low tissue specificity
{'Ciliated cells': '170.3', 'Basal respiratory cells': '1039.3', 'Club cells': '302.6', 'Ionocytes': '520.6', 'Mucus glandular cells': '139.3', 'Serous glandular cells': '194.1', 'Gastric mucus-secreting cells': '92.0', 'Proximal enterocytes': '230.2', 'Paneth cells': '139.3', 'Distal enterocytes': '208.8', 'Intestinal goblet cells': '139.1', 'Exocrine glandular cells': '-0.718', 'Basal prostatic cells': '231.1', 'Prostatic glandular cells': '111.3', 'Breast glandular cells': '-0.165', 'Breast myoepithelial cells': '-0.216', 'Glandular and luminal cells': '158.9', 'Secretory cells': '171.5', 'Basal keratinocytes': '203.6', 'Suprabasal keratinocytes': '335.4', 'Basal squamous epithelial cells': '132.1', 'Squamous epithelial cells': '131.0', 'Alveolar cells type 1': '-0.048', 'Alveolar cells type 2': '0.105', 'Salivary duct cells': '158.8', 'Ductal cells': '0.698', 'Hepatocytes': '0.478', 'Cholangiocytes': '141.2', 'Proximal tubular cells': '0.393', 'Distal tubular cells': '344.2', 'Collecting duct cells': '173.1', 'Mesothelial cells': '-0.016', 'Sertoli cells': '0.579', 'Granulosa cells': '78.4', 'Enteroendocrine cells': '143.5', 'Pancreatic endocrine cells': '623.2', 'Leydig cells': '0.708', 'Excitatory neurons': '31.4', 'Inhibitory neurons': '35.5', 'Cone photoreceptor cells': '384.0', 'Rod photoreceptor cells': '130.9', 'Bipolar cells': '198.7', 'Horizontal cells': '209.6', 'Astrocytes': '19.2', 'Oligodendrocyte precursor cells': '18.9', 'Oligodendrocytes': '20.3', 'Microglial cells': '24.2', 'Muller glia cells': '237.7', 'Schwann cells': '0.050', 'Spermatogonia': '0.565', 'Spermatocytes': '0.081', 'Early spermatids': '-0.556', 'Late spermatids': '-0.666', 'Oocytes': '252.2', 'Cytotrophoblasts': '307.6', 'Syncytiotrophoblasts': '351.3', 'Extravillous trophoblasts': '825.4', 'Endothelial cells': '168.7', 'Lymphatic endothelial cells': '85.8', 'Cardiomyocytes': '0.715', 'Skeletal myocytes': '0.366', 'Smooth muscle cells': '132.6', 'Adipocytes': '154.7', 'Melanocytes': '0.099', 'Fibroblasts': '163.4', 'Peritubular cells': '0.511', 'Endometrial stromal cells': '112.7', 'Ovarian stromal cells': '88.3', 'Undifferentiated cells': '181.2', 'T-cells': '251.9', 'B-cells': '154.5', 'Plasma cells': '242.6', 'Nk-cells': '203.4', 'Granulocytes': '188.8', 'Monocytes': '646.3', 'Macrophages': '295.7', 'Hofbauer cells': '506.9', 'Kupffer cells': '353.8', 'Dendritic cells': '146.3', 'Langerhans cells': '0.055', 'Erythroid cells': '-0.031', 'Adipocytes (Subcutaneous)': '0.083', 'Adipocytes (Visceral)': '0.058', 'Breast glandular cells (progenitors)': '-0.385', 'Adipocytes (Breast)': '0.266', 'Colon enterocytes': '0.005', 'Colon enteroendocrine cells': '0.090', 'Enteric glia cells': '-0.246', 'Mitotic cells (Colon)': '0.224', 'Mitotic cells (Heart)': '0.491', 'Podocytes': '0.071', 'Ascending Loop of Henle cells': '0.264', 'Intercalated cells': '0.029', 'Cholangiocyte': '0.377', 'NK-cells (Liver)': '-0.455', 'Respiratory ciliated cells': '-0.149', 'Mitotic cells (Lung)': '0.153', 'NK-cells (Lung)': '-0.016', 'B-cells (Lung)': '-0.114', 'Alpha cells': '0.378', 'Beta cells': '0.211', 'Prostate glandular cells': '-0.138', 'Prostate basal glandular cells': '0.022', 'Urothelial cells': '-0.009', 'Keratinocyte (other)': '0.082', 'Keratinocyte (granular)': '-0.273', 'Hair cortex cells': '0.140', 'Inner root sheath cells': '0.176', 'Outer root sheath cells': '0.265', 'Sebaceous gland cells': '0.133', 'Eccrine sweat gland cells': '0.099', 'Adipocytes (Skin)': '-0.045', 'Mitotic cells (Skin)': '0.279', 'Parietal cells': '-0.559', 'Chief cells': '-0.521', 'Gastric mucous cells': '-0.157', 'Gastric enteroendocrine cells': '-0.397', 'Mitotic cells (Stomach)': '0.280', 'Parafollicular cells': '0.120', 'Thyroid glandular cells': '0.340', 'Mitotic cells (Thyroid)': '0.024', 'Adrenal cortex cells': '0.526', 'Adrenal medulla cells': '0.064', 'Mitotic cells (Adrenal gland)': '0.365', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '-0.294', 'Minor salivary gland basal cells': '0.669', 'Mitotic cells (Minor salivary gland)': '0.685', 'Adipocytes (Minor salivary gland)': '0.226', 'Somatotropes': '-0.050', 'Lactotropes': '-0.145', 'Gonadotropes': '-0.147', 'Corticotropes': '-0.043', 'Thyrotropes': '0.104', 'Undifferentiated cells (Pituitary gland)': '0.187', 'Mitotic cells (Spleen)': '-0.003', 'Platelets': '0.072', 'Erythrocytes': '-0.081', 'Hematopoietic stem cells': '0.143', 'B-cells (Spleen)': '0.019', 'NK-cells (Spleen)': '-0.106', 'Amygdala excitatory': '31.3', 'Cerebellar inhibitory': '93.1', 'Cge interneuron': '54.6', 'Deep-layer corticothalamic and 6b': '36.4', 'Deep-layer intratelencephalic': '39.7', 'Deep-layer near-projecting': '50.4', 'Eccentric medium spiny neuron': '34.8', 'Hippocampal ca1-3': '38.7', 'Hippocampal ca4': '36.3', 'Hippocampal dentate gyrus': '31.7', 'Lamp5-lhx6 and chandelier': '66.5', 'Lower rhombic lip': '59.1', 'Mammillary body': '73.0', 'Medium spiny neuron': '34.5', 'Mge interneuron': '62.5', 'Midbrain-derived inhibitory': '63.2', 'Miscellaneous': '45.7', 'Splatter': '59.3', 'Thalamic excitatory': '69.9', 'Upper rhombic lip': '64.8', 'Upper-layer intratelencephalic': '43.9', 'Astrocyte': '45.4', 'Bergmann glia': '42.9', 'Central nervous system macrophage': '80.0', 'Choroid plexus epithelial cell': '65.6', 'Committed oligodendrocyte precursor': '34.4', 'Ependymal cell': '40.8', 'Oligodendrocyte': '31.8', 'Oligodendrocyte precursor cell': '34.3', 'Endothelial cell': '91.3', 'Pericyte': '74.1', 'Vascular associated smooth muscle cell': '75.2', 'Fibroblast': '42.6', 'Leukocyte': '106.2', 'Basophil': '480.3', 'Eosinophil': '321.6', 'Neutrophil': '1094.7', 'Classical monocyte': '376.7', 'Non-classical monocyte': '623.9', 'Intermediate monocyte': '1236.0', 'T-reg': '375.4', 'GdT-cell': '122.1', 'MAIT T-cell': '444.2', 'Memory CD4 T-cell': '144.6', 'Naive CD4 T-cell': '198.3', 'Memory CD8 T-cell': '132.8', 'Naive CD8 T-cell': '211.1', 'Memory B-cell': '128.8', 'Naive B-cell': '112.0', 'Plasmacytoid DC': '728.0', 'Myeloid DC': '962.9', 'NK-cell': '188.0', 'Total PBMC': '638.2', 'Vd2 gdTCR': '418.9', 'Memory CD4 T-cell Th1\\/Th17': '235.6', 'Memory CD4 T-cell Th17': '241.0', 'Memory CD4 T-cell Th2': '240.6', 'Non-Vd2 gdTCR': '428.8', 'Memory CD4 T-cell Th1': '212.7', 'Memory CD4 T-cell TFH': '216.3', 'Terminal effector memory CD4 T-cell': '412.4', 'Central memory CD8 T-cell': '440.0', 'Effector memory CD8 T-cell': '458.9', 'Terminal effector memory CD8 T-cell': '418.7', 'Non-switched memory B-cell': '381.9', 'Plasmablast': '751.5', 'Switched memory B-cell': '443.2', 'Exhausted memory B-cell': '365.4', 'Progenitor cell': '358.7', 'Memory T-reg': '207.6', 'Naive CD4 T-cell activated': '557.0', 'Naive CD8 T-cell activated': '578.4', 'Naive T-reg': '172.4'}
2WZB, 2WZC, 2WZD, 2X13, 2X14, 2X15, 2XE6, 2XE7, 2XE8, 2Y3I, 2YBE, 2ZGV, 3C39, 3C3A, 3C3B, 3C3C, 3ZOZ, 4AXX, 4O33, 5M1R, 5M3U, 5M6Z, 5MXM, 5NP8, 5O7D, 8YHP
{'Adipose Tissue': 125.14246677740864, 'Adrenal Gland': 132.23275193798452, 'Bladder': 118.84142857142858, 'Blood': 353.6018622174381, 'Blood Vessel': 144.50428464419477, 'Brain': 82.81007797123391, 'Breast': 106.51581699346406, 'Cervix Uteri': 108.49315789473684, 'Colon': 91.54413350449296, 'Esophagus': 155.73878892733563, 'Fallopian Tube': 102.36555555555556, 'Heart': 105.07325087108016, 'Kidney': 109.75011235955056, 'Liver': 59.75872566371681, 'Lung': 147.78505190311418, 'Muscle': 146.73891656288916, 'Nerve': 108.76877221324716, 'Ovary': 94.76777777777778, 'Pancreas': 27.62601524390244, 'Pituitary': 96.489222614841, 'Prostate': 88.5474693877551, 'Salivary Gland': 111.174012345679, 'Skin': 188.3184300718629, 'Small Intestine': 98.7881818181818, 'Spleen': 127.44149377593362, 'Stomach': 78.99392757660166, 'Testis': 37.02085872576178, 'Thyroid': 111.92630934150075, 'Uterus': 95.42302816901407, 'Vagina': 146.8651282051282}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
96.53012
0.277218
1,903
O60260
P04075
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ALDOA
MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVSNHAY
Homo sapiens
Cytoplasm, myofibril, sarcomere, I band, Cytoplasm, myofibril, sarcomere, M line
Group enriched (skeletal muscle, tongue)
{'Ciliated cells': '16.4', 'Basal respiratory cells': '91.1', 'Club cells': '40.4', 'Ionocytes': '46.0', 'Mucus glandular cells': '16.3', 'Serous glandular cells': '19.0', 'Gastric mucus-secreting cells': '358.4', 'Proximal enterocytes': '109.2', 'Paneth cells': '80.9', 'Distal enterocytes': '158.3', 'Intestinal goblet cells': '37.7', 'Exocrine glandular cells': '-0.809', 'Basal prostatic cells': '25.0', 'Prostatic glandular cells': '14.5', 'Breast glandular cells': '0.003', 'Breast myoepithelial cells': '-0.134', 'Glandular and luminal cells': '13.5', 'Secretory cells': '16.1', 'Basal keratinocytes': '62.5', 'Suprabasal keratinocytes': '80.3', 'Basal squamous epithelial cells': '779.8', 'Squamous epithelial cells': '1033.3', 'Alveolar cells type 1': '-0.213', 'Alveolar cells type 2': '0.111', 'Salivary duct cells': '21.0', 'Ductal cells': '0.524', 'Hepatocytes': '0.271', 'Cholangiocytes': '13.4', 'Proximal tubular cells': '0.181', 'Distal tubular cells': '95.3', 'Collecting duct cells': '40.8', 'Mesothelial cells': '0.046', 'Sertoli cells': '0.083', 'Granulosa cells': '20.1', 'Enteroendocrine cells': '37.3', 'Pancreatic endocrine cells': '134.1', 'Leydig cells': '0.266', 'Excitatory neurons': '64.0', 'Inhibitory neurons': '67.0', 'Cone photoreceptor cells': '11.9', 'Rod photoreceptor cells': '6.9', 'Bipolar cells': '7.3', 'Horizontal cells': '10.7', 'Astrocytes': '79.0', 'Oligodendrocyte precursor cells': '37.7', 'Oligodendrocytes': '56.6', 'Microglial cells': '48.3', 'Muller glia cells': '16.8', 'Schwann cells': '0.024', 'Spermatogonia': '0.223', 'Spermatocytes': '-0.238', 'Early spermatids': '-0.181', 'Late spermatids': '-0.077', 'Oocytes': '6.6', 'Cytotrophoblasts': '49.3', 'Syncytiotrophoblasts': '55.9', 'Extravillous trophoblasts': '87.5', 'Endothelial cells': '34.0', 'Lymphatic endothelial cells': '5.0', 'Cardiomyocytes': '0.785', 'Skeletal myocytes': '0.725', 'Smooth muscle cells': '62.5', 'Adipocytes': '11.5', 'Melanocytes': '-0.036', 'Fibroblasts': '63.0', 'Peritubular cells': '0.356', 'Endometrial stromal cells': '9.6', 'Ovarian stromal cells': '18.7', 'Undifferentiated cells': '45.4', 'T-cells': '94.6', 'B-cells': '102.3', 'Plasma cells': '219.6', 'Nk-cells': '20.8', 'Granulocytes': '13.8', 'Monocytes': '51.2', 'Macrophages': '133.0', 'Hofbauer cells': '50.8', 'Kupffer cells': '26.0', 'Dendritic cells': '11.9', 'Langerhans cells': '-0.002', 'Erythroid cells': '0.049', 'Adipocytes (Subcutaneous)': '0.307', 'Adipocytes (Visceral)': '0.348', 'Breast glandular cells (progenitors)': '-0.240', 'Adipocytes (Breast)': '0.199', 'Colon enterocytes': '-0.244', 'Colon enteroendocrine cells': '0.041', 'Enteric glia cells': '-0.072', 'Mitotic cells (Colon)': '-0.132', 'Mitotic cells (Heart)': '0.404', 'Podocytes': '-0.069', 'Ascending Loop of Henle cells': '0.359', 'Intercalated cells': '-0.073', 'Cholangiocyte': '0.446', 'NK-cells (Liver)': '-0.397', 'Respiratory ciliated cells': '-0.153', 'Mitotic cells (Lung)': '0.140', 'NK-cells (Lung)': '-0.216', 'B-cells (Lung)': '-0.177', 'Alpha cells': '0.350', 'Beta cells': '0.136', 'Prostate glandular cells': '-0.297', 'Prostate basal glandular cells': '-0.058', 'Urothelial cells': '-0.022', 'Keratinocyte (other)': '-0.003', 'Keratinocyte (granular)': '-0.200', 'Hair cortex cells': '0.115', 'Inner root sheath cells': '0.119', 'Outer root sheath cells': '0.205', 'Sebaceous gland cells': '0.170', 'Eccrine sweat gland cells': '0.089', 'Adipocytes (Skin)': '-0.026', 'Mitotic cells (Skin)': '0.137', 'Parietal cells': '-0.636', 'Chief cells': '-0.605', 'Gastric mucous cells': '-0.235', 'Gastric enteroendocrine cells': '-0.486', 'Mitotic cells (Stomach)': '0.159', 'Parafollicular cells': '0.159', 'Thyroid glandular cells': '0.422', 'Mitotic cells (Thyroid)': '-0.089', 'Adrenal cortex cells': '0.462', 'Adrenal medulla cells': '0.089', 'Mitotic cells (Adrenal gland)': '0.351', 'Minor salivary glandular cells': '0.048', 'Minor salivary gland ductal cells': '-0.165', 'Minor salivary gland basal cells': '0.505', 'Mitotic cells (Minor salivary gland)': '0.482', 'Adipocytes (Minor salivary gland)': '0.299', 'Somatotropes': '-0.019', 'Lactotropes': '-0.032', 'Gonadotropes': '-0.162', 'Corticotropes': '0.060', 'Thyrotropes': '0.107', 'Undifferentiated cells (Pituitary gland)': '0.061', 'Mitotic cells (Spleen)': '-0.248', 'Platelets': '-0.046', 'Erythrocytes': '-0.080', 'Hematopoietic stem cells': '0.058', 'B-cells (Spleen)': '0.017', 'NK-cells (Spleen)': '-0.067', 'Amygdala excitatory': '58.0', 'Cerebellar inhibitory': '187.6', 'Cge interneuron': '163.1', 'Deep-layer corticothalamic and 6b': '100.0', 'Deep-layer intratelencephalic': '102.6', 'Deep-layer near-projecting': '117.9', 'Eccentric medium spiny neuron': '88.8', 'Hippocampal ca1-3': '59.2', 'Hippocampal ca4': '182.9', 'Hippocampal dentate gyrus': '88.4', 'Lamp5-lhx6 and chandelier': '169.2', 'Lower rhombic lip': '201.0', 'Mammillary body': '127.0', 'Medium spiny neuron': '60.3', 'Mge interneuron': '113.7', 'Midbrain-derived inhibitory': '188.7', 'Miscellaneous': '124.8', 'Splatter': '165.5', 'Thalamic excitatory': '169.8', 'Upper rhombic lip': '169.2', 'Upper-layer intratelencephalic': '91.6', 'Astrocyte': '107.4', 'Bergmann glia': '164.7', 'Central nervous system macrophage': '56.9', 'Choroid plexus epithelial cell': '140.6', 'Committed oligodendrocyte precursor': '83.0', 'Ependymal cell': '115.9', 'Oligodendrocyte': '100.7', 'Oligodendrocyte precursor cell': '68.3', 'Endothelial cell': '95.9', 'Pericyte': '415.6', 'Vascular associated smooth muscle cell': '180.1', 'Fibroblast': '84.1', 'Leukocyte': '120.2', 'Basophil': '1201.8', 'Eosinophil': '2087.0', 'Neutrophil': '3024.3', 'Classical monocyte': '338.4', 'Non-classical monocyte': '318.9', 'Intermediate monocyte': '2411.5', 'T-reg': '988.1', 'GdT-cell': '1010.4', 'MAIT T-cell': '1048.3', 'Memory CD4 T-cell': '1093.7', 'Naive CD4 T-cell': '93.9', 'Memory CD8 T-cell': '1046.1', 'Naive CD8 T-cell': '124.9', 'Memory B-cell': '910.0', 'Naive B-cell': '46.7', 'Plasmacytoid DC': '905.9', 'Myeloid DC': '2040.0', 'NK-cell': '139.1', 'Total PBMC': '1763.4', 'Vd2 gdTCR': '1126.6', 'Memory CD4 T-cell Th1\\/Th17': '119.8', 'Memory CD4 T-cell Th17': '172.0', 'Memory CD4 T-cell Th2': '175.8', 'Non-Vd2 gdTCR': '1095.3', 'Memory CD4 T-cell Th1': '181.8', 'Memory CD4 T-cell TFH': '245.1', 'Terminal effector memory CD4 T-cell': '830.2', 'Central memory CD8 T-cell': '947.7', 'Effector memory CD8 T-cell': '1100.2', 'Terminal effector memory CD8 T-cell': '1041.7', 'Non-switched memory B-cell': '862.6', 'Plasmablast': '1463.5', 'Switched memory B-cell': '960.2', 'Exhausted memory B-cell': '896.2', 'Progenitor cell': '912.8', 'Memory T-reg': '264.8', 'Naive CD4 T-cell activated': '176.7', 'Naive CD8 T-cell activated': '240.8', 'Naive T-reg': '152.4'}
1ALD, 2ALD, 4ALD, 5KY6, 6XMH, 6XML, 6XMM, 6XMO
{'Adipose Tissue': 441.3689368770763, 'Adrenal Gland': 451.0937984496124, 'Bladder': 691.4, 'Blood': 768.1367384284176, 'Blood Vessel': 634.6471910112359, 'Brain': 438.23729371688114, 'Breast': 427.5934640522876, 'Cervix Uteri': 464.0473684210526, 'Colon': 567.8991014120668, 'Esophagus': 774.1091349480969, 'Fallopian Tube': 454.05555555555554, 'Heart': 792.1133449477352, 'Kidney': 360.81910112359554, 'Liver': 82.69097345132744, 'Lung': 398.0015570934256, 'Muscle': 3399.557907845579, 'Nerve': 351.79224555735055, 'Ovary': 476.5177777777778, 'Pancreas': 122.66024390243902, 'Pituitary': 459.6017667844523, 'Prostate': 440.4395918367347, 'Salivary Gland': 608.020987654321, 'Skin': 589.6222222222223, 'Small Intestine': 353.45828877005346, 'Spleen': 335.9182572614108, 'Stomach': 384.00027855153206, 'Testis': 196.3905540166205, 'Thyroid': 453.0323124042879, 'Uterus': 467.4077464788732, 'Vagina': 657.0602564102563}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
96.409011
0.260852
2,119
O60260
P04792
33082525
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
HSPB1
MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAK
Homo sapiens
Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, spindle
Tissue enhanced (esophagus)
{'Ciliated cells': '938.0', 'Basal respiratory cells': '2996.5', 'Club cells': '1527.0', 'Ionocytes': '1689.4', 'Mucus glandular cells': '700.8', 'Serous glandular cells': '594.7', 'Gastric mucus-secreting cells': '196.9', 'Proximal enterocytes': '70.4', 'Paneth cells': '1624.6', 'Distal enterocytes': '1421.9', 'Intestinal goblet cells': '252.5', 'Exocrine glandular cells': '-0.549', 'Basal prostatic cells': '521.3', 'Prostatic glandular cells': '507.2', 'Breast glandular cells': '-0.016', 'Breast myoepithelial cells': '0.031', 'Glandular and luminal cells': '1085.6', 'Secretory cells': '757.2', 'Basal keratinocytes': '2230.6', 'Suprabasal keratinocytes': '4840.6', 'Basal squamous epithelial cells': '2594.8', 'Squamous epithelial cells': '6790.4', 'Alveolar cells type 1': '-0.017', 'Alveolar cells type 2': '-0.591', 'Salivary duct cells': '950.3', 'Ductal cells': '0.442', 'Hepatocytes': '0.125', 'Cholangiocytes': '246.1', 'Proximal tubular cells': '0.066', 'Distal tubular cells': '1128.0', 'Collecting duct cells': '1114.4', 'Mesothelial cells': '0.120', 'Sertoli cells': '0.525', 'Granulosa cells': '885.8', 'Enteroendocrine cells': '289.5', 'Pancreatic endocrine cells': '3375.6', 'Leydig cells': '0.570', 'Excitatory neurons': '4.1', 'Inhibitory neurons': '2.1', 'Cone photoreceptor cells': '203.9', 'Rod photoreceptor cells': '39.0', 'Bipolar cells': '217.1', 'Horizontal cells': '107.0', 'Astrocytes': '74.3', 'Oligodendrocyte precursor cells': '7.5', 'Oligodendrocytes': '2.5', 'Microglial cells': '34.0', 'Muller glia cells': '161.6', 'Schwann cells': '-0.042', 'Spermatogonia': '0.362', 'Spermatocytes': '-0.182', 'Early spermatids': '-0.635', 'Late spermatids': '-0.546', 'Oocytes': '501.4', 'Cytotrophoblasts': '139.6', 'Syncytiotrophoblasts': '3385.0', 'Extravillous trophoblasts': '372.7', 'Endothelial cells': '900.4', 'Lymphatic endothelial cells': '1632.0', 'Cardiomyocytes': '0.432', 'Skeletal myocytes': '-0.124', 'Smooth muscle cells': '1446.2', 'Adipocytes': '675.1', 'Melanocytes': '0.115', 'Fibroblasts': '653.1', 'Peritubular cells': '0.487', 'Endometrial stromal cells': '942.6', 'Ovarian stromal cells': '1368.2', 'Undifferentiated cells': '217.0', 'T-cells': '215.5', 'B-cells': '204.3', 'Plasma cells': '368.9', 'Nk-cells': '37.6', 'Granulocytes': '412.3', 'Monocytes': '73.7', 'Macrophages': '548.4', 'Hofbauer cells': '1034.0', 'Kupffer cells': '116.1', 'Dendritic cells': '44.0', 'Langerhans cells': '0.112', 'Erythroid cells': '0.146', 'Adipocytes (Subcutaneous)': '-0.385', 'Adipocytes (Visceral)': '-0.183', 'Breast glandular cells (progenitors)': '-0.209', 'Adipocytes (Breast)': '0.011', 'Colon enterocytes': '-0.173', 'Colon enteroendocrine cells': '0.036', 'Enteric glia cells': '0.182', 'Mitotic cells (Colon)': '-0.101', 'Mitotic cells (Heart)': '0.395', 'Podocytes': '-0.017', 'Ascending Loop of Henle cells': '0.112', 'Intercalated cells': '-0.096', 'Cholangiocyte': '0.284', 'NK-cells (Liver)': '0.078', 'Respiratory ciliated cells': '0.091', 'Mitotic cells (Lung)': '-0.129', 'NK-cells (Lung)': '0.290', 'B-cells (Lung)': '0.223', 'Alpha cells': '0.163', 'Beta cells': '0.015', 'Prostate glandular cells': '-0.385', 'Prostate basal glandular cells': '-0.201', 'Urothelial cells': '0.060', 'Keratinocyte (other)': '0.563', 'Keratinocyte (granular)': '0.126', 'Hair cortex cells': '-0.046', 'Inner root sheath cells': '-0.113', 'Outer root sheath cells': '0.025', 'Sebaceous gland cells': '-0.233', 'Eccrine sweat gland cells': '-0.276', 'Adipocytes (Skin)': '-0.421', 'Mitotic cells (Skin)': '0.137', 'Parietal cells': '-0.728', 'Chief cells': '-0.561', 'Gastric mucous cells': '-0.611', 'Gastric enteroendocrine cells': '-0.431', 'Mitotic cells (Stomach)': '-0.198', 'Parafollicular cells': '0.015', 'Thyroid glandular cells': '0.147', 'Mitotic cells (Thyroid)': '0.098', 'Adrenal cortex cells': '0.114', 'Adrenal medulla cells': '-0.125', 'Mitotic cells (Adrenal gland)': '0.183', 'Minor salivary glandular cells': '0.078', 'Minor salivary gland ductal cells': '-0.288', 'Minor salivary gland basal cells': '0.688', 'Mitotic cells (Minor salivary gland)': '0.679', 'Adipocytes (Minor salivary gland)': '0.259', 'Somatotropes': '-0.368', 'Lactotropes': '-0.194', 'Gonadotropes': '0.085', 'Corticotropes': '-0.088', 'Thyrotropes': '0.025', 'Undifferentiated cells (Pituitary gland)': '0.330', 'Mitotic cells (Spleen)': '-0.269', 'Platelets': '-0.247', 'Erythrocytes': '-0.048', 'Hematopoietic stem cells': '-0.218', 'B-cells (Spleen)': '0.002', 'NK-cells (Spleen)': '0.101', 'Amygdala excitatory': '4.7', 'Cerebellar inhibitory': '5.7', 'Cge interneuron': '6.4', 'Deep-layer corticothalamic and 6b': '2.5', 'Deep-layer intratelencephalic': '4.9', 'Deep-layer near-projecting': '1.6', 'Eccentric medium spiny neuron': '5.2', 'Hippocampal ca1-3': '3.2', 'Hippocampal ca4': '6.7', 'Hippocampal dentate gyrus': '2.3', 'Lamp5-lhx6 and chandelier': '8.7', 'Lower rhombic lip': '43.6', 'Mammillary body': '4.2', 'Medium spiny neuron': '4.4', 'Mge interneuron': '5.2', 'Midbrain-derived inhibitory': '7.0', 'Miscellaneous': '2.9', 'Splatter': '15.7', 'Thalamic excitatory': '18.1', 'Upper rhombic lip': '6.0', 'Upper-layer intratelencephalic': '6.6', 'Astrocyte': '205.4', 'Bergmann glia': '42.5', 'Central nervous system macrophage': '111.4', 'Choroid plexus epithelial cell': '70.3', 'Committed oligodendrocyte precursor': '17.7', 'Ependymal cell': '103.1', 'Oligodendrocyte': '4.0', 'Oligodendrocyte precursor cell': '15.9', 'Endothelial cell': '342.9', 'Pericyte': '180.4', 'Vascular associated smooth muscle cell': '632.2', 'Fibroblast': '74.7', 'Leukocyte': '65.7', 'Basophil': '1.0', 'Eosinophil': '11.0', 'Neutrophil': '0.0', 'Classical monocyte': '4.6', 'Non-classical monocyte': '14.0', 'Intermediate monocyte': '13.7', 'T-reg': '9.2', 'GdT-cell': '59.0', 'MAIT T-cell': '2.8', 'Memory CD4 T-cell': '92.7', 'Naive CD4 T-cell': '22.6', 'Memory CD8 T-cell': '62.1', 'Naive CD8 T-cell': '39.7', 'Memory B-cell': '115.6', 'Naive B-cell': '7.3', 'Plasmacytoid DC': '7.3', 'Myeloid DC': '2.5', 'NK-cell': '10.7', 'Total PBMC': '9.1', 'Vd2 gdTCR': '7.5', 'Memory CD4 T-cell Th1\\/Th17': '15.3', 'Memory CD4 T-cell Th17': '32.8', 'Memory CD4 T-cell Th2': '36.3', 'Non-Vd2 gdTCR': '8.0', 'Memory CD4 T-cell Th1': '36.3', 'Memory CD4 T-cell TFH': '68.7', 'Terminal effector memory CD4 T-cell': '7.0', 'Central memory CD8 T-cell': '6.9', 'Effector memory CD8 T-cell': '5.1', 'Terminal effector memory CD8 T-cell': '8.8', 'Non-switched memory B-cell': '4.6', 'Plasmablast': '1.0', 'Switched memory B-cell': '7.4', 'Exhausted memory B-cell': '29.1', 'Progenitor cell': '10.9', 'Memory T-reg': '45.4', 'Naive CD4 T-cell activated': '25.2', 'Naive CD8 T-cell activated': '31.5', 'Naive T-reg': '42.7'}
2N3J, 3Q9P, 3Q9Q, 4MJH, 6DV5, 6GJH
{'Adipose Tissue': 733.9707641196013, 'Adrenal Gland': 661.2176356589147, 'Bladder': 1668.3761904761905, 'Blood': 194.10298600645856, 'Blood Vessel': 3369.0042696629216, 'Brain': 234.118485995458, 'Breast': 558.0772113289761, 'Cervix Uteri': 1572.0842105263157, 'Colon': 1377.93, 'Esophagus': 2709.4579238754327, 'Fallopian Tube': 1219.5555555555557, 'Heart': 1085.3725551684088, 'Kidney': 623.4247191011236, 'Liver': 241.9483628318584, 'Lung': 1015.1904844290656, 'Muscle': 1460.1612702366126, 'Nerve': 531.051857835218, 'Ovary': 937.43, 'Pancreas': 300.48893292682925, 'Pituitary': 366.5570671378091, 'Prostate': 1063.744081632653, 'Salivary Gland': 823.2987654320988, 'Skin': 1423.4473742399114, 'Small Intestine': 492.8503743315508, 'Spleen': 234.18663900414936, 'Stomach': 641.9988579387186, 'Testis': 131.79085872576178, 'Thyroid': 801.7191424196018, 'Uterus': 2522.325352112676, 'Vagina': 3408.8512820512824}
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[41.93, 51.52, 52.88, 65.56, 70.56, 60.29, 53.05, 51.81, 53.25, 46.02, 43.14, 38.66, 44.94, 39.04, 44.58, 34.93, 42.07, 40.44, 50.42, 49.43, 40.33, 38.28, 37.69, 38.38, 29.27, 30.37, 39.79, 39.95, 35.42, 38.74, 48.05, 43.84, 40.32, 40.28, 45.16, 43.05, 44.13, 51.29, 49.37, 55.76, 51.06, 51.23, 53.05, 45.25, 47.76, 49.16, 49.02, 42.9, 46.96, 42.36, 45.9, 40.82, 50.18, 47.76, 46.59, 50.94, 45.98, 49.73, 51.64, 39.97, 46.77, 42.12, 41.77, 42.41, 42.05, 42.02, 39.7, 44.83, 45.94, 51.19, 47.37, 51.37, 45.57, 56.17, 57.32, 54.56, 55.0, 56.26, 55.37, 47.95, 46.29, 47.87, 52.08, 53.75, 62.53, 74.64, 79.91, 83.95, 81.3, 80.15, 81.01, 80.88, 87.73, 91.28, 92.77, 94.11, 91.97, 92.39, 91.23, 89.97, 91.0, 88.96, 88.54, 92.01, 92.49, 94.99, 96.03, 95.31, 96.38, 97.56, 97.08, 96.82, 95.6, 93.32, 93.28, 92.05, 94.6, 95.6, 95.69, 95.35, 95.9, 95.48, 96.04, 92.88, 94.01, 93.61, 89.04, 88.82, 82.87, 80.94, 81.19, 88.56, 88.09, 87.33, 90.8, 90.14, 91.94, 92.63, 92.33, 91.28, 93.44, 92.33, 92.84, 92.62, 91.45, 89.71, 90.1, 92.06, 92.0, 93.11, 92.79, 93.88, 95.73, 96.47, 96.37, 96.57, 95.55, 93.19, 90.84, 87.96, 89.75, 92.28, 95.16, 95.46, 95.99, 95.76, 95.29, 94.62, 91.64, 87.05, 80.35, 66.85, 57.39, 52.11, 50.32, 50.8, 61.52, 70.97, 78.08, 81.9, 83.67, 85.66, 82.65, 82.4, 81.61, 75.49, 70.5, 58.84, 54.53, 54.52, 54.92, 52.78, 54.91, 57.75, 52.69, 51.6, 56.54, 54.66, 59.8, 57.92, 58.7, 45.02, 55.46, 60.1, 45.95]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
68.055171
0.61239
2,719
O60260
P06576
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ATP5F1B
MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHSS
Homo sapiens
Mitochondrion inner membrane
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '237.7', 'Basal respiratory cells': '998.3', 'Club cells': '375.3', 'Ionocytes': '635.1', 'Mucus glandular cells': '154.4', 'Serous glandular cells': '237.4', 'Gastric mucus-secreting cells': '264.1', 'Proximal enterocytes': '961.7', 'Paneth cells': '568.2', 'Distal enterocytes': '1190.3', 'Intestinal goblet cells': '531.2', 'Exocrine glandular cells': '-0.704', 'Basal prostatic cells': '277.1', 'Prostatic glandular cells': '128.4', 'Breast glandular cells': '-0.284', 'Breast myoepithelial cells': '-0.408', 'Glandular and luminal cells': '175.8', 'Secretory cells': '310.6', 'Basal keratinocytes': '405.9', 'Suprabasal keratinocytes': '399.6', 'Basal squamous epithelial cells': '247.1', 'Squamous epithelial cells': '356.4', 'Alveolar cells type 1': '-0.094', 'Alveolar cells type 2': '0.196', 'Salivary duct cells': '311.5', 'Ductal cells': '0.579', 'Hepatocytes': '0.540', 'Cholangiocytes': '335.8', 'Proximal tubular cells': '0.364', 'Distal tubular cells': '946.6', 'Collecting duct cells': '262.6', 'Mesothelial cells': '-0.054', 'Sertoli cells': '0.371', 'Granulosa cells': '172.7', 'Enteroendocrine cells': '608.4', 'Pancreatic endocrine cells': '451.7', 'Leydig cells': '0.319', 'Excitatory neurons': '42.2', 'Inhibitory neurons': '49.1', 'Cone photoreceptor cells': '577.7', 'Rod photoreceptor cells': '212.9', 'Bipolar cells': '205.5', 'Horizontal cells': '134.1', 'Astrocytes': '42.7', 'Oligodendrocyte precursor cells': '19.8', 'Oligodendrocytes': '32.3', 'Microglial cells': '35.8', 'Muller glia cells': '236.8', 'Schwann cells': '0.005', 'Spermatogonia': '0.483', 'Spermatocytes': '0.542', 'Early spermatids': '0.220', 'Late spermatids': '-0.185', 'Oocytes': '297.0', 'Cytotrophoblasts': '852.4', 'Syncytiotrophoblasts': '1167.9', 'Extravillous trophoblasts': '566.7', 'Endothelial cells': '206.3', 'Lymphatic endothelial cells': '194.1', 'Cardiomyocytes': '0.817', 'Skeletal myocytes': '0.494', 'Smooth muscle cells': '259.9', 'Adipocytes': '163.8', 'Melanocytes': '0.059', 'Fibroblasts': '221.5', 'Peritubular cells': '0.128', 'Endometrial stromal cells': '170.0', 'Ovarian stromal cells': '187.1', 'Undifferentiated cells': '830.4', 'T-cells': '190.5', 'B-cells': '182.5', 'Plasma cells': '344.8', 'Nk-cells': '164.0', 'Granulocytes': '195.6', 'Monocytes': '405.0', 'Macrophages': '236.6', 'Hofbauer cells': '540.5', 'Kupffer cells': '260.0', 'Dendritic cells': '232.1', 'Langerhans cells': '0.044', 'Erythroid cells': '-0.059', 'Adipocytes (Subcutaneous)': '0.543', 'Adipocytes (Visceral)': '0.625', 'Breast glandular cells (progenitors)': '-0.244', 'Adipocytes (Breast)': '0.567', 'Colon enterocytes': '0.147', 'Colon enteroendocrine cells': '-0.034', 'Enteric glia cells': '-0.586', 'Mitotic cells (Colon)': '0.099', 'Mitotic cells (Heart)': '0.327', 'Podocytes': '-0.002', 'Ascending Loop of Henle cells': '0.406', 'Intercalated cells': '0.165', 'Cholangiocyte': '0.368', 'NK-cells (Liver)': '-0.416', 'Respiratory ciliated cells': '-0.105', 'Mitotic cells (Lung)': '0.236', 'NK-cells (Lung)': '-0.189', 'B-cells (Lung)': '-0.254', 'Alpha cells': '0.382', 'Beta cells': '0.202', 'Prostate glandular cells': '-0.108', 'Prostate basal glandular cells': '0.124', 'Urothelial cells': '0.044', 'Keratinocyte (other)': '0.055', 'Keratinocyte (granular)': '-0.145', 'Hair cortex cells': '0.093', 'Inner root sheath cells': '0.149', 'Outer root sheath cells': '0.152', 'Sebaceous gland cells': '0.336', 'Eccrine sweat gland cells': '0.127', 'Adipocytes (Skin)': '0.028', 'Mitotic cells (Skin)': '0.221', 'Parietal cells': '0.411', 'Chief cells': '0.055', 'Gastric mucous cells': '0.456', 'Gastric enteroendocrine cells': '0.037', 'Mitotic cells (Stomach)': '0.383', 'Parafollicular cells': '0.090', 'Thyroid glandular cells': '0.379', 'Mitotic cells (Thyroid)': '-0.044', 'Adrenal cortex cells': '0.595', 'Adrenal medulla cells': '0.070', 'Mitotic cells (Adrenal gland)': '0.439', 'Minor salivary glandular cells': '-0.010', 'Minor salivary gland ductal cells': '-0.092', 'Minor salivary gland basal cells': '0.585', 'Mitotic cells (Minor salivary gland)': '0.567', 'Adipocytes (Minor salivary gland)': '0.342', 'Somatotropes': '0.081', 'Lactotropes': '0.093', 'Gonadotropes': '0.119', 'Corticotropes': '0.097', 'Thyrotropes': '0.219', 'Undifferentiated cells (Pituitary gland)': '0.053', 'Mitotic cells (Spleen)': '0.043', 'Platelets': '0.011', 'Erythrocytes': '-0.148', 'Hematopoietic stem cells': '0.041', 'B-cells (Spleen)': '0.145', 'NK-cells (Spleen)': '-0.045', 'Amygdala excitatory': '38.2', 'Cerebellar inhibitory': '144.4', 'Cge interneuron': '76.9', 'Deep-layer corticothalamic and 6b': '50.3', 'Deep-layer intratelencephalic': '46.9', 'Deep-layer near-projecting': '59.9', 'Eccentric medium spiny neuron': '50.4', 'Hippocampal ca1-3': '54.1', 'Hippocampal ca4': '61.1', 'Hippocampal dentate gyrus': '40.5', 'Lamp5-lhx6 and chandelier': '85.5', 'Lower rhombic lip': '97.6', 'Mammillary body': '93.6', 'Medium spiny neuron': '48.2', 'Mge interneuron': '80.4', 'Midbrain-derived inhibitory': '96.0', 'Miscellaneous': '67.7', 'Splatter': '75.1', 'Thalamic excitatory': '98.0', 'Upper rhombic lip': '123.5', 'Upper-layer intratelencephalic': '45.7', 'Astrocyte': '45.1', 'Bergmann glia': '75.7', 'Central nervous system macrophage': '44.7', 'Choroid plexus epithelial cell': '110.9', 'Committed oligodendrocyte precursor': '57.7', 'Ependymal cell': '75.0', 'Oligodendrocyte': '41.3', 'Oligodendrocyte precursor cell': '51.4', 'Endothelial cell': '62.3', 'Pericyte': '154.7', 'Vascular associated smooth muscle cell': '104.1', 'Fibroblast': '49.2', 'Leukocyte': '58.9', 'Basophil': '814.7', 'Eosinophil': '282.4', 'Neutrophil': '591.3', 'Classical monocyte': '745.7', 'Non-classical monocyte': '1160.9', 'Intermediate monocyte': '2078.1', 'T-reg': '904.9', 'GdT-cell': '294.0', 'MAIT T-cell': '1205.3', 'Memory CD4 T-cell': '276.2', 'Naive CD4 T-cell': '589.4', 'Memory CD8 T-cell': '313.6', 'Naive CD8 T-cell': '623.9', 'Memory B-cell': '304.2', 'Naive B-cell': '421.2', 'Plasmacytoid DC': '1833.4', 'Myeloid DC': '2195.2', 'NK-cell': '767.3', 'Total PBMC': '1261.7', 'Vd2 gdTCR': '1086.1', 'Memory CD4 T-cell Th1\\/Th17': '693.7', 'Memory CD4 T-cell Th17': '708.7', 'Memory CD4 T-cell Th2': '679.2', 'Non-Vd2 gdTCR': '1200.0', 'Memory CD4 T-cell Th1': '630.7', 'Memory CD4 T-cell TFH': '591.5', 'Terminal effector memory CD4 T-cell': '1062.9', 'Central memory CD8 T-cell': '1014.6', 'Effector memory CD8 T-cell': '1338.8', 'Terminal effector memory CD8 T-cell': '1164.9', 'Non-switched memory B-cell': '1003.3', 'Plasmablast': '2559.4', 'Switched memory B-cell': '1195.0', 'Exhausted memory B-cell': '1091.0', 'Progenitor cell': '1229.0', 'Memory T-reg': '657.1', 'Naive CD4 T-cell activated': '951.2', 'Naive CD8 T-cell activated': '1037.3', 'Naive T-reg': '510.4'}
8H9E, 8H9I, 8H9L, 8H9P, 8H9S, 8H9T, 8H9U, 8H9V, 8KI3
{}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
85.334764
0.34966
1,482
O60260
P06733
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ENO1
MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK
Homo sapiens
Cytoplasm, Cell membrane, Cytoplasm, myofibril, sarcomere, M line, Nucleus
Low tissue specificity
{'Ciliated cells': '234.0', 'Basal respiratory cells': '1786.3', 'Club cells': '435.6', 'Ionocytes': '609.7', 'Mucus glandular cells': '309.6', 'Serous glandular cells': '387.6', 'Gastric mucus-secreting cells': '141.5', 'Proximal enterocytes': '821.6', 'Paneth cells': '284.8', 'Distal enterocytes': '460.5', 'Intestinal goblet cells': '217.2', 'Exocrine glandular cells': '-0.740', 'Basal prostatic cells': '238.1', 'Prostatic glandular cells': '97.4', 'Breast glandular cells': '0.280', 'Breast myoepithelial cells': '0.139', 'Glandular and luminal cells': '271.7', 'Secretory cells': '408.7', 'Basal keratinocytes': '687.1', 'Suprabasal keratinocytes': '760.5', 'Basal squamous epithelial cells': '394.7', 'Squamous epithelial cells': '448.5', 'Alveolar cells type 1': '-0.164', 'Alveolar cells type 2': '0.488', 'Salivary duct cells': '439.3', 'Ductal cells': '0.699', 'Hepatocytes': '0.332', 'Cholangiocytes': '274.7', 'Proximal tubular cells': '0.183', 'Distal tubular cells': '670.0', 'Collecting duct cells': '548.4', 'Mesothelial cells': '-0.071', 'Sertoli cells': '-0.097', 'Granulosa cells': '254.9', 'Enteroendocrine cells': '329.2', 'Pancreatic endocrine cells': '1609.7', 'Leydig cells': '-0.063', 'Excitatory neurons': '30.9', 'Inhibitory neurons': '31.8', 'Cone photoreceptor cells': '290.6', 'Rod photoreceptor cells': '140.9', 'Bipolar cells': '182.8', 'Horizontal cells': '251.8', 'Astrocytes': '94.4', 'Oligodendrocyte precursor cells': '26.9', 'Oligodendrocytes': '25.0', 'Microglial cells': '29.5', 'Muller glia cells': '2541.6', 'Schwann cells': '-0.001', 'Spermatogonia': '0.102', 'Spermatocytes': '0.139', 'Early spermatids': '0.454', 'Late spermatids': '0.319', 'Oocytes': '189.0', 'Cytotrophoblasts': '1143.3', 'Syncytiotrophoblasts': '919.3', 'Extravillous trophoblasts': '2170.5', 'Endothelial cells': '273.2', 'Lymphatic endothelial cells': '187.7', 'Cardiomyocytes': '0.391', 'Skeletal myocytes': '-0.224', 'Smooth muscle cells': '210.5', 'Adipocytes': '130.2', 'Melanocytes': '0.042', 'Fibroblasts': '374.6', 'Peritubular cells': '-0.102', 'Endometrial stromal cells': '232.0', 'Ovarian stromal cells': '212.6', 'Undifferentiated cells': '583.6', 'T-cells': '271.2', 'B-cells': '207.3', 'Plasma cells': '306.0', 'Nk-cells': '241.4', 'Granulocytes': '256.7', 'Monocytes': '493.0', 'Macrophages': '444.0', 'Hofbauer cells': '1095.9', 'Kupffer cells': '342.3', 'Dendritic cells': '150.6', 'Langerhans cells': '-0.097', 'Erythroid cells': '-0.059', 'Adipocytes (Subcutaneous)': '0.140', 'Adipocytes (Visceral)': '0.185', 'Breast glandular cells (progenitors)': '0.168', 'Adipocytes (Breast)': '-0.128', 'Colon enterocytes': '-0.068', 'Colon enteroendocrine cells': '-0.028', 'Enteric glia cells': '-0.217', 'Mitotic cells (Colon)': '0.163', 'Mitotic cells (Heart)': '0.479', 'Podocytes': '-0.193', 'Ascending Loop of Henle cells': '0.382', 'Intercalated cells': '-0.182', 'Cholangiocyte': '0.371', 'NK-cells (Liver)': '-0.478', 'Respiratory ciliated cells': '-0.207', 'Mitotic cells (Lung)': '0.245', 'NK-cells (Lung)': '-0.367', 'B-cells (Lung)': '-0.293', 'Alpha cells': '0.360', 'Beta cells': '0.199', 'Prostate glandular cells': '-0.164', 'Prostate basal glandular cells': '0.155', 'Urothelial cells': '0.094', 'Keratinocyte (other)': '-0.091', 'Keratinocyte (granular)': '-0.334', 'Hair cortex cells': '0.234', 'Inner root sheath cells': '0.237', 'Outer root sheath cells': '0.306', 'Sebaceous gland cells': '0.138', 'Eccrine sweat gland cells': '0.236', 'Adipocytes (Skin)': '0.073', 'Mitotic cells (Skin)': '0.197', 'Parietal cells': '-0.556', 'Chief cells': '-0.508', 'Gastric mucous cells': '-0.155', 'Gastric enteroendocrine cells': '-0.378', 'Mitotic cells (Stomach)': '0.315', 'Parafollicular cells': '0.047', 'Thyroid glandular cells': '0.309', 'Mitotic cells (Thyroid)': '0.011', 'Adrenal cortex cells': '0.372', 'Adrenal medulla cells': '0.058', 'Mitotic cells (Adrenal gland)': '0.220', 'Minor salivary glandular cells': '0.421', 'Minor salivary gland ductal cells': '-0.165', 'Minor salivary gland basal cells': '0.693', 'Mitotic cells (Minor salivary gland)': '0.686', 'Adipocytes (Minor salivary gland)': '0.230', 'Somatotropes': '-0.268', 'Lactotropes': '-0.301', 'Gonadotropes': '-0.218', 'Corticotropes': '-0.077', 'Thyrotropes': '-0.040', 'Undifferentiated cells (Pituitary gland)': '0.360', 'Mitotic cells (Spleen)': '0.031', 'Platelets': '0.029', 'Erythrocytes': '-0.050', 'Hematopoietic stem cells': '0.115', 'B-cells (Spleen)': '0.124', 'NK-cells (Spleen)': '-0.152', 'Amygdala excitatory': '48.1', 'Cerebellar inhibitory': '88.0', 'Cge interneuron': '53.3', 'Deep-layer corticothalamic and 6b': '53.2', 'Deep-layer intratelencephalic': '48.0', 'Deep-layer near-projecting': '54.3', 'Eccentric medium spiny neuron': '62.2', 'Hippocampal ca1-3': '58.9', 'Hippocampal ca4': '69.4', 'Hippocampal dentate gyrus': '53.1', 'Lamp5-lhx6 and chandelier': '51.8', 'Lower rhombic lip': '77.7', 'Mammillary body': '48.2', 'Medium spiny neuron': '54.6', 'Mge interneuron': '50.5', 'Midbrain-derived inhibitory': '59.0', 'Miscellaneous': '60.5', 'Splatter': '62.4', 'Thalamic excitatory': '54.8', 'Upper rhombic lip': '46.5', 'Upper-layer intratelencephalic': '44.6', 'Astrocyte': '164.0', 'Bergmann glia': '246.1', 'Central nervous system macrophage': '51.7', 'Choroid plexus epithelial cell': '101.2', 'Committed oligodendrocyte precursor': '47.9', 'Ependymal cell': '149.6', 'Oligodendrocyte': '38.3', 'Oligodendrocyte precursor cell': '62.8', 'Endothelial cell': '37.1', 'Pericyte': '54.1', 'Vascular associated smooth muscle cell': '58.2', 'Fibroblast': '55.4', 'Leukocyte': '91.5', 'Basophil': '189.7', 'Eosinophil': '232.9', 'Neutrophil': '312.9', 'Classical monocyte': '658.2', 'Non-classical monocyte': '549.8', 'Intermediate monocyte': '1340.7', 'T-reg': '710.7', 'GdT-cell': '529.5', 'MAIT T-cell': '896.7', 'Memory CD4 T-cell': '554.0', 'Naive CD4 T-cell': '250.2', 'Memory CD8 T-cell': '543.2', 'Naive CD8 T-cell': '297.6', 'Memory B-cell': '412.7', 'Naive B-cell': '112.9', 'Plasmacytoid DC': '849.0', 'Myeloid DC': '1893.9', 'NK-cell': '321.3', 'Total PBMC': '1125.3', 'Vd2 gdTCR': '810.9', 'Memory CD4 T-cell Th1\\/Th17': '333.9', 'Memory CD4 T-cell Th17': '385.6', 'Memory CD4 T-cell Th2': '335.5', 'Non-Vd2 gdTCR': '850.9', 'Memory CD4 T-cell Th1': '364.1', 'Memory CD4 T-cell TFH': '395.0', 'Terminal effector memory CD4 T-cell': '774.4', 'Central memory CD8 T-cell': '751.2', 'Effector memory CD8 T-cell': '917.3', 'Terminal effector memory CD8 T-cell': '817.0', 'Non-switched memory B-cell': '638.0', 'Plasmablast': '1271.1', 'Switched memory B-cell': '710.8', 'Exhausted memory B-cell': '635.9', 'Progenitor cell': '1755.0', 'Memory T-reg': '468.4', 'Naive CD4 T-cell activated': '2375.0', 'Naive CD8 T-cell activated': '2447.7', 'Naive T-reg': '281.4'}
2PSN, 3B97, 5JLZ, 5LAX, 5NI9, 5NIG, 5OCK
{'Adipose Tissue': 647.2210963455149, 'Adrenal Gland': 488.95531007751936, 'Bladder': 741.1095238095238, 'Blood': 1305.9258772874057, 'Blood Vessel': 995.8647191011236, 'Brain': 540.5707191521575, 'Breast': 601.6150326797385, 'Cervix Uteri': 541.0, 'Colon': 496.06867779204106, 'Esophagus': 947.7308788927336, 'Fallopian Tube': 520.8777777777777, 'Heart': 201.86211962833912, 'Kidney': 719.1280898876405, 'Liver': 390.111592920354, 'Lung': 780.8975778546712, 'Muscle': 160.2435491905355, 'Nerve': 752.8483037156705, 'Ovary': 530.285, 'Pancreas': 129.6220731707317, 'Pituitary': 398.69611307420496, 'Prostate': 479.05795918367346, 'Salivary Gland': 754.574074074074, 'Skin': 1312.5953012714206, 'Small Intestine': 514.2347593582888, 'Spleen': 556.3053941908714, 'Stomach': 374.65434540389975, 'Testis': 395.1728531855955, 'Thyroid': 504.83215926493114, 'Uterus': 533.1887323943662, 'Vagina': 811.0608974358975}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
97.562419
0.23424
1,793
O60260
P07437
12716939, E3Net
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
TUBB
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA
Homo sapiens
Cytoplasm, cytoskeleton
Low tissue specificity
{'Ciliated cells': '82.1', 'Basal respiratory cells': '636.2', 'Club cells': '209.6', 'Ionocytes': '221.6', 'Mucus glandular cells': '154.0', 'Serous glandular cells': '197.9', 'Gastric mucus-secreting cells': '99.0', 'Proximal enterocytes': '112.3', 'Paneth cells': '114.5', 'Distal enterocytes': '98.3', 'Intestinal goblet cells': '162.7', 'Exocrine glandular cells': '-0.738', 'Basal prostatic cells': '123.7', 'Prostatic glandular cells': '85.1', 'Breast glandular cells': '-0.132', 'Breast myoepithelial cells': '-0.037', 'Glandular and luminal cells': '145.8', 'Secretory cells': '299.8', 'Basal keratinocytes': '428.1', 'Suprabasal keratinocytes': '339.4', 'Basal squamous epithelial cells': '370.7', 'Squamous epithelial cells': '423.4', 'Alveolar cells type 1': '-0.212', 'Alveolar cells type 2': '-0.091', 'Salivary duct cells': '158.5', 'Ductal cells': '0.663', 'Hepatocytes': '0.485', 'Cholangiocytes': '242.3', 'Proximal tubular cells': '0.149', 'Distal tubular cells': '153.7', 'Collecting duct cells': '165.3', 'Mesothelial cells': '0.229', 'Sertoli cells': '0.682', 'Granulosa cells': '345.3', 'Enteroendocrine cells': '113.4', 'Pancreatic endocrine cells': '976.3', 'Leydig cells': '0.763', 'Excitatory neurons': '27.2', 'Inhibitory neurons': '23.9', 'Cone photoreceptor cells': '107.0', 'Rod photoreceptor cells': '55.6', 'Bipolar cells': '78.4', 'Horizontal cells': '86.2', 'Astrocytes': '20.4', 'Oligodendrocyte precursor cells': '18.9', 'Oligodendrocytes': '21.3', 'Microglial cells': '29.5', 'Muller glia cells': '198.7', 'Schwann cells': '0.107', 'Spermatogonia': '0.589', 'Spermatocytes': '0.123', 'Early spermatids': '-0.530', 'Late spermatids': '-0.682', 'Oocytes': '55.1', 'Cytotrophoblasts': '876.9', 'Syncytiotrophoblasts': '220.7', 'Extravillous trophoblasts': '2539.2', 'Endothelial cells': '307.9', 'Lymphatic endothelial cells': '304.2', 'Cardiomyocytes': '0.540', 'Skeletal myocytes': '-0.099', 'Smooth muscle cells': '316.6', 'Adipocytes': '206.6', 'Melanocytes': '0.247', 'Fibroblasts': '439.4', 'Peritubular cells': '0.588', 'Endometrial stromal cells': '254.5', 'Ovarian stromal cells': '653.8', 'Undifferentiated cells': '483.1', 'T-cells': '209.2', 'B-cells': '223.7', 'Plasma cells': '367.2', 'Nk-cells': '167.8', 'Granulocytes': '196.2', 'Monocytes': '182.1', 'Macrophages': '280.1', 'Hofbauer cells': '816.2', 'Kupffer cells': '321.3', 'Dendritic cells': '201.8', 'Langerhans cells': '0.079', 'Erythroid cells': '-0.184', 'Adipocytes (Subcutaneous)': '-0.205', 'Adipocytes (Visceral)': '-0.024', 'Breast glandular cells (progenitors)': '-0.074', 'Adipocytes (Breast)': '0.238', 'Colon enterocytes': '-0.154', 'Colon enteroendocrine cells': '0.214', 'Enteric glia cells': '-0.033', 'Mitotic cells (Colon)': '-0.015', 'Mitotic cells (Heart)': '0.553', 'Podocytes': '-0.166', 'Ascending Loop of Henle cells': '0.415', 'Intercalated cells': '-0.108', 'Cholangiocyte': '0.245', 'NK-cells (Liver)': '-0.366', 'Respiratory ciliated cells': '-0.051', 'Mitotic cells (Lung)': '0.288', 'NK-cells (Lung)': '0.105', 'B-cells (Lung)': '0.068', 'Alpha cells': '0.351', 'Beta cells': '0.202', 'Prostate glandular cells': '-0.398', 'Prostate basal glandular cells': '-0.136', 'Urothelial cells': '-0.084', 'Keratinocyte (other)': '-0.144', 'Keratinocyte (granular)': '-0.314', 'Hair cortex cells': '0.361', 'Inner root sheath cells': '0.408', 'Outer root sheath cells': '0.474', 'Sebaceous gland cells': '0.209', 'Eccrine sweat gland cells': '0.180', 'Adipocytes (Skin)': '0.159', 'Mitotic cells (Skin)': '0.353', 'Parietal cells': '-0.706', 'Chief cells': '-0.546', 'Gastric mucous cells': '-0.311', 'Gastric enteroendocrine cells': '-0.432', 'Mitotic cells (Stomach)': '0.272', 'Parafollicular cells': '0.034', 'Thyroid glandular cells': '0.255', 'Mitotic cells (Thyroid)': '0.050', 'Adrenal cortex cells': '0.289', 'Adrenal medulla cells': '0.051', 'Mitotic cells (Adrenal gland)': '0.219', 'Minor salivary glandular cells': '0.445', 'Minor salivary gland ductal cells': '-0.159', 'Minor salivary gland basal cells': '0.534', 'Mitotic cells (Minor salivary gland)': '0.685', 'Adipocytes (Minor salivary gland)': '0.266', 'Somatotropes': '-0.382', 'Lactotropes': '-0.304', 'Gonadotropes': '-0.049', 'Corticotropes': '-0.245', 'Thyrotropes': '-0.037', 'Undifferentiated cells (Pituitary gland)': '0.397', 'Mitotic cells (Spleen)': '0.354', 'Platelets': '0.169', 'Erythrocytes': '0.105', 'Hematopoietic stem cells': '0.183', 'B-cells (Spleen)': '-0.074', 'NK-cells (Spleen)': '-0.125', 'Amygdala excitatory': '46.0', 'Cerebellar inhibitory': '39.9', 'Cge interneuron': '67.7', 'Deep-layer corticothalamic and 6b': '56.5', 'Deep-layer intratelencephalic': '49.9', 'Deep-layer near-projecting': '70.1', 'Eccentric medium spiny neuron': '66.1', 'Hippocampal ca1-3': '39.4', 'Hippocampal ca4': '71.9', 'Hippocampal dentate gyrus': '31.0', 'Lamp5-lhx6 and chandelier': '63.1', 'Lower rhombic lip': '88.2', 'Mammillary body': '65.9', 'Medium spiny neuron': '36.0', 'Mge interneuron': '45.7', 'Midbrain-derived inhibitory': '72.7', 'Miscellaneous': '60.2', 'Splatter': '95.7', 'Thalamic excitatory': '117.7', 'Upper rhombic lip': '76.2', 'Upper-layer intratelencephalic': '31.8', 'Astrocyte': '19.8', 'Bergmann glia': '34.4', 'Central nervous system macrophage': '53.7', 'Choroid plexus epithelial cell': '42.3', 'Committed oligodendrocyte precursor': '57.3', 'Ependymal cell': '29.3', 'Oligodendrocyte': '38.1', 'Oligodendrocyte precursor cell': '39.0', 'Endothelial cell': '91.0', 'Pericyte': '79.0', 'Vascular associated smooth muscle cell': '83.2', 'Fibroblast': '64.1', 'Leukocyte': '53.9', 'Basophil': '194.8', 'Eosinophil': '123.0', 'Neutrophil': '122.1', 'Classical monocyte': '79.5', 'Non-classical monocyte': '206.6', 'Intermediate monocyte': '325.8', 'T-reg': '259.3', 'GdT-cell': '187.7', 'MAIT T-cell': '236.9', 'Memory CD4 T-cell': '152.8', 'Naive CD4 T-cell': '81.7', 'Memory CD8 T-cell': '188.7', 'Naive CD8 T-cell': '74.8', 'Memory B-cell': '166.5', 'Naive B-cell': '30.5', 'Plasmacytoid DC': '514.8', 'Myeloid DC': '166.2', 'NK-cell': '103.2', 'Total PBMC': '257.6', 'Vd2 gdTCR': '188.9', 'Memory CD4 T-cell Th1\\/Th17': '75.4', 'Memory CD4 T-cell Th17': '101.5', 'Memory CD4 T-cell Th2': '93.8', 'Non-Vd2 gdTCR': '247.5', 'Memory CD4 T-cell Th1': '85.3', 'Memory CD4 T-cell TFH': '87.2', 'Terminal effector memory CD4 T-cell': '288.2', 'Central memory CD8 T-cell': '194.3', 'Effector memory CD8 T-cell': '258.4', 'Terminal effector memory CD8 T-cell': '276.7', 'Non-switched memory B-cell': '184.7', 'Plasmablast': '352.2', 'Switched memory B-cell': '297.6', 'Exhausted memory B-cell': '225.0', 'Progenitor cell': '349.7', 'Memory T-reg': '125.8', 'Naive CD4 T-cell activated': '223.1', 'Naive CD8 T-cell activated': '254.1', 'Naive T-reg': '103.5'}
3QNZ, 3QO0, 5N5N, 6I2I, 6QUS, 6QUY, 6QVE, 6QVJ, 7TRG, 7TTN, 7TTT, 7TUB, 7X0S, 8BPO, 9BP6
{'Adipose Tissue': 283.1232059800665, 'Adrenal Gland': 166.123992248062, 'Bladder': 285.0238095238095, 'Blood': 330.50600968783635, 'Blood Vessel': 318.90352059925095, 'Brain': 152.46971612414836, 'Breast': 241.25383442265797, 'Cervix Uteri': 361.3894736842105, 'Colon': 274.2903209242619, 'Esophagus': 271.70677508650516, 'Fallopian Tube': 368.9888888888889, 'Heart': 119.31530778164924, 'Kidney': 104.02168539325844, 'Liver': 130.86685840707963, 'Lung': 302.7294117647059, 'Muscle': 94.07353673723536, 'Nerve': 320.56187399030694, 'Ovary': 583.1377777777778, 'Pancreas': 69.42807926829268, 'Pituitary': 135.93102473498234, 'Prostate': 200.24718367346935, 'Salivary Gland': 182.1066049382716, 'Skin': 455.7026257600885, 'Small Intestine': 199.778128342246, 'Spleen': 249.4435684647303, 'Stomach': 175.88364902506964, 'Testis': 136.2153462603878, 'Thyroid': 229.16019908116385, 'Uterus': 482.7366197183099, 'Vagina': 314.01}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
91.793896
0.265045
1,765
O60260
P07951
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
TPM2
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
Homo sapiens
Cytoplasm, cytoskeleton
Group enriched (skeletal muscle, tongue)
{'Ciliated cells': '80.0', 'Basal respiratory cells': '261.7', 'Club cells': '39.2', 'Ionocytes': '60.0', 'Mucus glandular cells': '40.2', 'Serous glandular cells': '33.3', 'Gastric mucus-secreting cells': '94.9', 'Proximal enterocytes': '0.0', 'Paneth cells': '0.1', 'Distal enterocytes': '2.5', 'Intestinal goblet cells': '1.4', 'Exocrine glandular cells': '-0.477', 'Basal prostatic cells': '25.1', 'Prostatic glandular cells': '1.7', 'Breast glandular cells': '0.372', 'Breast myoepithelial cells': '0.631', 'Glandular and luminal cells': '19.7', 'Secretory cells': '49.1', 'Basal keratinocytes': '22.7', 'Suprabasal keratinocytes': '7.1', 'Basal squamous epithelial cells': '17.3', 'Squamous epithelial cells': '4.4', 'Alveolar cells type 1': '-0.049', 'Alveolar cells type 2': '-0.536', 'Salivary duct cells': '167.7', 'Ductal cells': '0.416', 'Hepatocytes': '-0.131', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.015', 'Distal tubular cells': '0.0', 'Collecting duct cells': '9.7', 'Mesothelial cells': '0.293', 'Sertoli cells': '0.461', 'Granulosa cells': '97.0', 'Enteroendocrine cells': '4.3', 'Pancreatic endocrine cells': '1091.8', 'Leydig cells': '0.545', 'Excitatory neurons': '2.5', 'Inhibitory neurons': '4.4', 'Cone photoreceptor cells': '0.0', 'Rod photoreceptor cells': '0.6', 'Bipolar cells': '1.6', 'Horizontal cells': '3.8', 'Astrocytes': '9.9', 'Oligodendrocyte precursor cells': '2.8', 'Oligodendrocytes': '0.4', 'Microglial cells': '8.9', 'Muller glia cells': '36.2', 'Schwann cells': '-0.042', 'Spermatogonia': '0.272', 'Spermatocytes': '-0.204', 'Early spermatids': '-0.613', 'Late spermatids': '-0.596', 'Oocytes': '23.5', 'Cytotrophoblasts': '11.5', 'Syncytiotrophoblasts': '8.5', 'Extravillous trophoblasts': '112.9', 'Endothelial cells': '79.1', 'Lymphatic endothelial cells': '47.4', 'Cardiomyocytes': '0.783', 'Skeletal myocytes': '0.637', 'Smooth muscle cells': '3613.2', 'Adipocytes': '98.9', 'Melanocytes': '-0.181', 'Fibroblasts': '517.6', 'Peritubular cells': '0.626', 'Endometrial stromal cells': '515.1', 'Ovarian stromal cells': '689.3', 'Undifferentiated cells': '41.2', 'T-cells': '21.4', 'B-cells': '14.0', 'Plasma cells': '19.4', 'Nk-cells': '1.7', 'Granulocytes': '41.7', 'Monocytes': '1.1', 'Macrophages': '40.7', 'Hofbauer cells': '22.4', 'Kupffer cells': '3.5', 'Dendritic cells': '295.2', 'Langerhans cells': '-0.145', 'Erythroid cells': '0.177', 'Adipocytes (Subcutaneous)': '-0.508', 'Adipocytes (Visceral)': '-0.462', 'Breast glandular cells (progenitors)': '0.340', 'Adipocytes (Breast)': '-0.536', 'Colon enterocytes': '-0.278', 'Colon enteroendocrine cells': '0.068', 'Enteric glia cells': '0.376', 'Mitotic cells (Colon)': '-0.199', 'Mitotic cells (Heart)': '0.421', 'Podocytes': '0.045', 'Ascending Loop of Henle cells': '0.406', 'Intercalated cells': '0.006', 'Cholangiocyte': '0.425', 'NK-cells (Liver)': '-0.012', 'Respiratory ciliated cells': '0.261', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.146', 'B-cells (Lung)': '0.102', 'Alpha cells': '0.409', 'Beta cells': '0.224', 'Prostate glandular cells': '-0.363', 'Prostate basal glandular cells': '-0.245', 'Urothelial cells': '-0.294', 'Keratinocyte (other)': '-0.414', 'Keratinocyte (granular)': '-0.382', 'Hair cortex cells': '0.291', 'Inner root sheath cells': '0.234', 'Outer root sheath cells': '0.401', 'Sebaceous gland cells': '0.125', 'Eccrine sweat gland cells': '0.461', 'Adipocytes (Skin)': '0.381', 'Mitotic cells (Skin)': '-0.002', 'Parietal cells': '-0.724', 'Chief cells': '-0.592', 'Gastric mucous cells': '-0.662', 'Gastric enteroendocrine cells': '-0.462', 'Mitotic cells (Stomach)': '-0.270', 'Parafollicular cells': '-0.082', 'Thyroid glandular cells': '-0.155', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.190', 'Adrenal medulla cells': '-0.091', 'Mitotic cells (Adrenal gland)': '-0.202', 'Minor salivary glandular cells': '0.046', 'Minor salivary gland ductal cells': '-0.013', 'Minor salivary gland basal cells': '0.097', 'Mitotic cells (Minor salivary gland)': '0.108', 'Adipocytes (Minor salivary gland)': '0.180', 'Somatotropes': '-0.300', 'Lactotropes': '-0.309', 'Gonadotropes': '0.037', 'Corticotropes': '-0.218', 'Thyrotropes': '-0.058', 'Undifferentiated cells (Pituitary gland)': '0.416', 'Mitotic cells (Spleen)': '-0.327', 'Platelets': '-0.077', 'Erythrocytes': '0.108', 'Hematopoietic stem cells': '-0.154', 'B-cells (Spleen)': '0.037', 'NK-cells (Spleen)': '0.139', 'Amygdala excitatory': '8.7', 'Cerebellar inhibitory': '5.7', 'Cge interneuron': '5.5', 'Deep-layer corticothalamic and 6b': '0.8', 'Deep-layer intratelencephalic': '4.3', 'Deep-layer near-projecting': '1.3', 'Eccentric medium spiny neuron': '5.0', 'Hippocampal ca1-3': '16.0', 'Hippocampal ca4': '4.5', 'Hippocampal dentate gyrus': '1.6', 'Lamp5-lhx6 and chandelier': '5.0', 'Lower rhombic lip': '2.6', 'Mammillary body': '1.8', 'Medium spiny neuron': '4.6', 'Mge interneuron': '9.4', 'Midbrain-derived inhibitory': '11.1', 'Miscellaneous': '4.4', 'Splatter': '3.3', 'Thalamic excitatory': '4.9', 'Upper rhombic lip': '7.6', 'Upper-layer intratelencephalic': '6.9', 'Astrocyte': '25.1', 'Bergmann glia': '11.6', 'Central nervous system macrophage': '7.3', 'Choroid plexus epithelial cell': '19.0', 'Committed oligodendrocyte precursor': '7.5', 'Ependymal cell': '14.1', 'Oligodendrocyte': '1.1', 'Oligodendrocyte precursor cell': '11.0', 'Endothelial cell': '24.2', 'Pericyte': '168.9', 'Vascular associated smooth muscle cell': '1056.0', 'Fibroblast': '40.4', 'Leukocyte': '3.6', 'Basophil': '0.9', 'Eosinophil': '0.0', 'Neutrophil': '1.5', 'Classical monocyte': '2.9', 'Non-classical monocyte': '0.9', 'Intermediate monocyte': '0.0', 'T-reg': '2.7', 'GdT-cell': '0.2', 'MAIT T-cell': '10.4', 'Memory CD4 T-cell': '0.0', 'Naive CD4 T-cell': '53.3', 'Memory CD8 T-cell': '0.3', 'Naive CD8 T-cell': '30.1', 'Memory B-cell': '0.1', 'Naive B-cell': '1.3', 'Plasmacytoid DC': '408.5', 'Myeloid DC': '2.5', 'NK-cell': '20.7', 'Total PBMC': '4.2', 'Vd2 gdTCR': '5.7', 'Memory CD4 T-cell Th1\\/Th17': '48.2', 'Memory CD4 T-cell Th17': '37.9', 'Memory CD4 T-cell Th2': '35.1', 'Non-Vd2 gdTCR': '1.2', 'Memory CD4 T-cell Th1': '46.8', 'Memory CD4 T-cell TFH': '37.3', 'Terminal effector memory CD4 T-cell': '3.1', 'Central memory CD8 T-cell': '2.9', 'Effector memory CD8 T-cell': '3.2', 'Terminal effector memory CD8 T-cell': '2.2', 'Non-switched memory B-cell': '1.4', 'Plasmablast': '1.3', 'Switched memory B-cell': '4.0', 'Exhausted memory B-cell': '1.1', 'Progenitor cell': '6.1', 'Memory T-reg': '27.7', 'Naive CD4 T-cell activated': '10.4', 'Naive CD8 T-cell activated': '6.5', 'Naive T-reg': '30.1'}
null
{'Adipose Tissue': 278.8157392026578, 'Adrenal Gland': 186.5467441860465, 'Bladder': 1515.2142857142858, 'Blood': 12.708446716899893, 'Blood Vessel': 3734.9731835205994, 'Brain': 37.18635844057532, 'Breast': 259.27263616557735, 'Cervix Uteri': 759.7552631578948, 'Colon': 2040.8442362002563, 'Esophagus': 2484.862034602076, 'Fallopian Tube': 976.1777777777778, 'Heart': 297.97249709639954, 'Kidney': 88.47112359550562, 'Liver': 16.135615044247785, 'Lung': 293.5692387543252, 'Muscle': 4111.7021170610205, 'Nerve': 293.31066235864296, 'Ovary': 463.29611111111114, 'Pancreas': 27.95624085365854, 'Pituitary': 90.34480565371024, 'Prostate': 1259.905306122449, 'Salivary Gland': 221.61777777777775, 'Skin': 207.29669430624656, 'Small Intestine': 525.5027272727273, 'Spleen': 133.59917012448133, 'Stomach': 978.9352646239556, 'Testis': 102.97285318559555, 'Thyroid': 167.4394027565084, 'Uterus': 1762.0753521126762, 'Vagina': 511.09121794871794}
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[52.2, 53.15, 58.19, 57.5, 59.48, 66.87, 69.12, 73.46, 70.85, 74.03, 70.67, 76.84, 78.17, 77.54, 78.75, 77.13, 78.72, 79.28, 81.02, 78.52, 79.49, 80.7, 81.27, 82.24, 82.19, 83.7, 84.96, 84.57, 87.84, 86.74, 86.88, 84.82, 87.79, 87.04, 87.75, 88.69, 90.13, 89.15, 89.36, 89.45, 89.65, 90.33, 91.11, 91.25, 91.6, 92.48, 92.34, 93.29, 93.25, 93.3, 93.69, 93.87, 93.76, 94.19, 94.47, 94.81, 95.12, 95.12, 95.38, 94.8, 94.92, 95.54, 95.98, 96.27, 95.74, 95.91, 96.05, 96.4, 96.34, 96.43, 96.31, 96.06, 96.22, 96.57, 96.81, 96.5, 96.8, 96.69, 96.58, 96.77, 96.65, 96.26, 96.71, 97.5, 97.82, 97.21, 97.48, 98.11, 98.14, 97.18, 98.0, 98.09, 97.82, 97.78, 98.3, 98.11, 97.4, 98.12, 98.19, 98.07, 97.68, 98.18, 98.26, 97.95, 97.88, 98.02, 98.34, 98.14, 98.39, 98.38, 98.4, 98.37, 98.25, 98.2, 97.94, 98.18, 98.22, 98.16, 97.81, 98.05, 97.95, 97.81, 97.8, 98.19, 98.08, 98.0, 98.07, 98.19, 98.31, 97.6, 97.86, 98.09, 98.42, 98.28, 98.22, 98.25, 98.34, 98.25, 98.13, 98.27, 98.08, 98.42, 98.36, 98.19, 98.42, 98.36, 98.4, 98.25, 98.44, 98.01, 98.31, 98.48, 98.06, 98.26, 98.38, 97.95, 98.23, 98.31, 98.39, 98.29, 98.28, 97.98, 98.12, 98.29, 98.38, 98.3, 98.22, 98.5, 98.3, 98.65, 98.34, 98.45, 98.26, 98.4, 98.43, 98.43, 98.49, 98.11, 98.55, 98.43, 98.37, 98.08, 98.19, 98.27, 98.33, 97.68, 98.28, 98.09, 98.22, 97.93, 97.72, 97.99, 98.05, 98.11, 97.89, 97.64, 97.93, 98.08, 98.21, 98.23, 98.22, 98.17, 98.09, 97.76, 97.2, 97.08, 97.01, 96.41, 96.37, 96.23, 95.99, 95.13, 95.88, 95.47, 95.85, 95.55, 95.91, 95.65, 95.62, 95.81, 94.81, 95.91, 95.86, 96.33, 96.15, 95.95, 95.84, 96.11, 96.71, 96.06, 95.71, 95.14, 95.6, 94.63, 94.8, 94.48, 93.56, 94.1, 93.54, 92.77, 93.63, 92.78, 91.22, 89.9, 92.49, 92.0, 89.89, 92.06, 90.97, 89.75, 90.52, 89.63, 89.54, 87.2, 87.89, 86.83, 85.35, 85.8, 85.26, 83.81, 83.31, 83.06, 78.57, 79.68, 80.0, 78.23, 77.59, 77.15, 76.06, 74.87, 71.23, 70.93, 73.62, 65.11, 66.9, 67.09, 65.72, 57.14, 58.85, 60.39, 56.0, 55.49, 53.78, 44.64]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
91.415423
0.573944
2,445
O60260
P08238
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
HSP90AB1
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
Homo sapiens
Cytoplasm, Melanosome, Nucleus, Secreted, Cell membrane, Dynein axonemal particle, Cell surface
Low tissue specificity
{'Ciliated cells': '1089.4', 'Basal respiratory cells': '816.4', 'Club cells': '756.7', 'Ionocytes': '520.9', 'Mucus glandular cells': '969.3', 'Serous glandular cells': '753.2', 'Gastric mucus-secreting cells': '614.3', 'Proximal enterocytes': '331.1', 'Paneth cells': '415.0', 'Distal enterocytes': '579.5', 'Intestinal goblet cells': '418.1', 'Exocrine glandular cells': '-0.625', 'Basal prostatic cells': '1621.0', 'Prostatic glandular cells': '1093.9', 'Breast glandular cells': '0.373', 'Breast myoepithelial cells': '0.419', 'Glandular and luminal cells': '1578.2', 'Secretory cells': '2132.4', 'Basal keratinocytes': '1205.0', 'Suprabasal keratinocytes': '1271.2', 'Basal squamous epithelial cells': '1283.1', 'Squamous epithelial cells': '1141.7', 'Alveolar cells type 1': '0.081', 'Alveolar cells type 2': '-0.355', 'Salivary duct cells': '1225.0', 'Ductal cells': '0.307', 'Hepatocytes': '0.359', 'Cholangiocytes': '513.2', 'Proximal tubular cells': '0.162', 'Distal tubular cells': '666.9', 'Collecting duct cells': '416.2', 'Mesothelial cells': '0.180', 'Sertoli cells': '0.537', 'Granulosa cells': '1639.2', 'Enteroendocrine cells': '574.9', 'Pancreatic endocrine cells': '837.1', 'Leydig cells': '0.583', 'Excitatory neurons': '99.9', 'Inhibitory neurons': '144.5', 'Cone photoreceptor cells': '356.8', 'Rod photoreceptor cells': '223.4', 'Bipolar cells': '297.1', 'Horizontal cells': '281.4', 'Astrocytes': '66.9', 'Oligodendrocyte precursor cells': '65.6', 'Oligodendrocytes': '118.6', 'Microglial cells': '73.4', 'Muller glia cells': '340.1', 'Schwann cells': '0.009', 'Spermatogonia': '0.747', 'Spermatocytes': '0.299', 'Early spermatids': '-0.478', 'Late spermatids': '-0.530', 'Oocytes': '899.9', 'Cytotrophoblasts': '1195.5', 'Syncytiotrophoblasts': '1133.4', 'Extravillous trophoblasts': '1088.2', 'Endothelial cells': '1079.1', 'Lymphatic endothelial cells': '1157.5', 'Cardiomyocytes': '0.603', 'Skeletal myocytes': '-0.223', 'Smooth muscle cells': '1032.7', 'Adipocytes': '1133.2', 'Melanocytes': '0.176', 'Fibroblasts': '1037.5', 'Peritubular cells': '0.396', 'Endometrial stromal cells': '1389.4', 'Ovarian stromal cells': '1790.9', 'Undifferentiated cells': '949.9', 'T-cells': '1067.7', 'B-cells': '996.7', 'Plasma cells': '965.9', 'Nk-cells': '519.8', 'Granulocytes': '2106.6', 'Monocytes': '780.1', 'Macrophages': '1002.2', 'Hofbauer cells': '727.5', 'Kupffer cells': '287.4', 'Dendritic cells': '537.0', 'Langerhans cells': '0.086', 'Erythroid cells': '-0.070', 'Adipocytes (Subcutaneous)': '-0.078', 'Adipocytes (Visceral)': '-0.180', 'Breast glandular cells (progenitors)': '0.368', 'Adipocytes (Breast)': '-0.458', 'Colon enterocytes': '-0.181', 'Colon enteroendocrine cells': '0.234', 'Enteric glia cells': '0.140', 'Mitotic cells (Colon)': '-0.107', 'Mitotic cells (Heart)': '0.430', 'Podocytes': '0.032', 'Ascending Loop of Henle cells': '0.244', 'Intercalated cells': '0.052', 'Cholangiocyte': '0.419', 'NK-cells (Liver)': '-0.301', 'Respiratory ciliated cells': '0.042', 'Mitotic cells (Lung)': '-0.148', 'NK-cells (Lung)': '0.272', 'B-cells (Lung)': '0.127', 'Alpha cells': '0.221', 'Beta cells': '0.087', 'Prostate glandular cells': '-0.066', 'Prostate basal glandular cells': '0.057', 'Urothelial cells': '0.135', 'Keratinocyte (other)': '0.223', 'Keratinocyte (granular)': '-0.093', 'Hair cortex cells': '0.020', 'Inner root sheath cells': '0.133', 'Outer root sheath cells': '0.077', 'Sebaceous gland cells': '-0.016', 'Eccrine sweat gland cells': '0.007', 'Adipocytes (Skin)': '-0.128', 'Mitotic cells (Skin)': '0.245', 'Parietal cells': '-0.521', 'Chief cells': '-0.284', 'Gastric mucous cells': '-0.363', 'Gastric enteroendocrine cells': '-0.260', 'Mitotic cells (Stomach)': '-0.048', 'Parafollicular cells': '0.102', 'Thyroid glandular cells': '0.356', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.523', 'Adrenal medulla cells': '0.011', 'Mitotic cells (Adrenal gland)': '0.198', 'Minor salivary glandular cells': '0.518', 'Minor salivary gland ductal cells': '-0.006', 'Minor salivary gland basal cells': '0.248', 'Mitotic cells (Minor salivary gland)': '0.362', 'Adipocytes (Minor salivary gland)': '0.211', 'Somatotropes': '0.014', 'Lactotropes': '0.103', 'Gonadotropes': '0.086', 'Corticotropes': '0.036', 'Thyrotropes': '0.241', 'Undifferentiated cells (Pituitary gland)': '0.164', 'Mitotic cells (Spleen)': '-0.082', 'Platelets': '-0.269', 'Erythrocytes': '-0.116', 'Hematopoietic stem cells': '-0.231', 'B-cells (Spleen)': '0.330', 'NK-cells (Spleen)': '0.074', 'Amygdala excitatory': '151.4', 'Cerebellar inhibitory': '384.7', 'Cge interneuron': '408.1', 'Deep-layer corticothalamic and 6b': '220.9', 'Deep-layer intratelencephalic': '192.7', 'Deep-layer near-projecting': '292.1', 'Eccentric medium spiny neuron': '205.2', 'Hippocampal ca1-3': '148.0', 'Hippocampal ca4': '255.6', 'Hippocampal dentate gyrus': '203.4', 'Lamp5-lhx6 and chandelier': '393.4', 'Lower rhombic lip': '393.3', 'Mammillary body': '291.3', 'Medium spiny neuron': '143.1', 'Mge interneuron': '274.6', 'Midbrain-derived inhibitory': '326.5', 'Miscellaneous': '237.1', 'Splatter': '350.9', 'Thalamic excitatory': '318.1', 'Upper rhombic lip': '311.9', 'Upper-layer intratelencephalic': '176.6', 'Astrocyte': '112.9', 'Bergmann glia': '148.7', 'Central nervous system macrophage': '157.9', 'Choroid plexus epithelial cell': '147.6', 'Committed oligodendrocyte precursor': '177.4', 'Ependymal cell': '211.4', 'Oligodendrocyte': '189.3', 'Oligodendrocyte precursor cell': '139.7', 'Endothelial cell': '338.9', 'Pericyte': '299.0', 'Vascular associated smooth muscle cell': '263.0', 'Fibroblast': '142.0', 'Leukocyte': '250.3', 'Basophil': '177.3', 'Eosinophil': '52.9', 'Neutrophil': '54.1', 'Classical monocyte': '430.7', 'Non-classical monocyte': '539.5', 'Intermediate monocyte': '612.9', 'T-reg': '781.5', 'GdT-cell': '344.4', 'MAIT T-cell': '1034.4', 'Memory CD4 T-cell': '381.3', 'Naive CD4 T-cell': '980.8', 'Memory CD8 T-cell': '394.9', 'Naive CD8 T-cell': '1121.9', 'Memory B-cell': '545.9', 'Naive B-cell': '1032.8', 'Plasmacytoid DC': '896.1', 'Myeloid DC': '676.6', 'NK-cell': '607.9', 'Total PBMC': '607.7', 'Vd2 gdTCR': '873.3', 'Memory CD4 T-cell Th1\\/Th17': '1080.5', 'Memory CD4 T-cell Th17': '1036.5', 'Memory CD4 T-cell Th2': '1002.0', 'Non-Vd2 gdTCR': '676.2', 'Memory CD4 T-cell Th1': '945.2', 'Memory CD4 T-cell TFH': '933.3', 'Terminal effector memory CD4 T-cell': '585.6', 'Central memory CD8 T-cell': '787.3', 'Effector memory CD8 T-cell': '777.5', 'Terminal effector memory CD8 T-cell': '682.6', 'Non-switched memory B-cell': '855.1', 'Plasmablast': '883.7', 'Switched memory B-cell': '764.0', 'Exhausted memory B-cell': '771.3', 'Progenitor cell': '1556.5', 'Memory T-reg': '786.5', 'Naive CD4 T-cell activated': '5057.9', 'Naive CD8 T-cell activated': '4974.7', 'Naive T-reg': '1021.0'}
1QZ2, 1UYM, 2L6J, 3FWV, 3NMQ, 3PRY, 3UQ3, 5FWK, 5FWL, 5FWM, 5FWP, 5UC4, 5UCH, 5UCI, 5UCJ, 6N8W, 6N8Y, 7ULJ, 7Z37, 7Z38, 7ZR0, 7ZR5, 7ZR6, 7ZUB, 8EOA, 8EOB, 8GAE, 8GFT, 8QMO
{'Adipose Tissue': 807.7548172757475, 'Adrenal Gland': 944.0635658914728, 'Bladder': 947.0571428571428, 'Blood': 536.8842841765339, 'Blood Vessel': 1003.7087640449438, 'Brain': 633.3272331566994, 'Breast': 795.354248366013, 'Cervix Uteri': 1223.057894736842, 'Colon': 630.3150192554557, 'Esophagus': 636.9689965397923, 'Fallopian Tube': 1105.2444444444443, 'Heart': 555.026806039489, 'Kidney': 472.3044943820225, 'Liver': 275.49845132743366, 'Lung': 1019.2501730103804, 'Muscle': 995.1388542963886, 'Nerve': 862.5090468497576, 'Ovary': 2019.5794444444443, 'Pancreas': 453.2039634146342, 'Pituitary': 1034.2858657243817, 'Prostate': 735.4461224489795, 'Salivary Gland': 591.4302469135803, 'Skin': 817.7583747927031, 'Small Intestine': 535.2529411764706, 'Spleen': 553.5883817427385, 'Stomach': 666.3075208913649, 'Testis': 552.2146814404432, 'Thyroid': 918.815773353752, 'Uterus': 1187.699295774648, 'Vagina': 959.7205128205128}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
84.099489
0.382845
938
O60260
P08247
16135753
UbiNet, UbiBrowser
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
SYP
MLLLADMDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTESDLSIEVEFEYPFRLHQVYFDAPTCRGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPVCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPAGSGGSGYGPQGDYGQQGYGPQGAPTSFSNQM
Homo sapiens
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Synapse, synaptosome
Tissue enhanced (brain, retina)
{'Ciliated cells': '1.2', 'Basal respiratory cells': '1.1', 'Club cells': '2.8', 'Ionocytes': '2.9', 'Mucus glandular cells': '0.8', 'Serous glandular cells': '0.8', 'Gastric mucus-secreting cells': '10.6', 'Proximal enterocytes': '16.4', 'Paneth cells': '3.2', 'Distal enterocytes': '7.4', 'Intestinal goblet cells': '30.5', 'Exocrine glandular cells': '-0.406', 'Basal prostatic cells': '2.9', 'Prostatic glandular cells': '0.9', 'Breast glandular cells': '0.218', 'Breast myoepithelial cells': '0.258', 'Glandular and luminal cells': '2.9', 'Secretory cells': '1.5', 'Basal keratinocytes': '2.7', 'Suprabasal keratinocytes': '2.0', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '3.5', 'Alveolar cells type 1': '0.254', 'Alveolar cells type 2': '-0.087', 'Salivary duct cells': '1.8', 'Ductal cells': '0.382', 'Hepatocytes': '0.109', 'Cholangiocytes': '1.9', 'Proximal tubular cells': '-0.119', 'Distal tubular cells': '0.0', 'Collecting duct cells': '7.8', 'Mesothelial cells': '0.230', 'Sertoli cells': '-0.099', 'Granulosa cells': '9.1', 'Enteroendocrine cells': '48.6', 'Pancreatic endocrine cells': '15.3', 'Leydig cells': '-0.042', 'Excitatory neurons': '111.3', 'Inhibitory neurons': '113.5', 'Cone photoreceptor cells': '462.2', 'Rod photoreceptor cells': '588.2', 'Bipolar cells': '471.7', 'Horizontal cells': '235.4', 'Astrocytes': '22.9', 'Oligodendrocyte precursor cells': '26.4', 'Oligodendrocytes': '31.4', 'Microglial cells': '17.0', 'Muller glia cells': '40.1', 'Schwann cells': '0.354', 'Spermatogonia': '0.069', 'Spermatocytes': '-0.004', 'Early spermatids': '0.027', 'Late spermatids': '0.174', 'Oocytes': '3.7', 'Cytotrophoblasts': '1.1', 'Syncytiotrophoblasts': '1.7', 'Extravillous trophoblasts': '0.6', 'Endothelial cells': '4.3', 'Lymphatic endothelial cells': '4.0', 'Cardiomyocytes': '0.351', 'Skeletal myocytes': '-0.107', 'Smooth muscle cells': '8.2', 'Adipocytes': '7.1', 'Melanocytes': '0.050', 'Fibroblasts': '3.6', 'Peritubular cells': '0.089', 'Endometrial stromal cells': '3.2', 'Ovarian stromal cells': '3.9', 'Undifferentiated cells': '7.1', 'T-cells': '2.7', 'B-cells': '4.1', 'Plasma cells': '2.0', 'Nk-cells': '2.4', 'Granulocytes': '1.5', 'Monocytes': '1.1', 'Macrophages': '3.8', 'Hofbauer cells': '0.9', 'Kupffer cells': '3.4', 'Dendritic cells': '0.8', 'Langerhans cells': '0.175', 'Erythroid cells': '-0.056', 'Adipocytes (Subcutaneous)': '-0.396', 'Adipocytes (Visceral)': '-0.205', 'Breast glandular cells (progenitors)': '0.253', 'Adipocytes (Breast)': '-0.129', 'Colon enterocytes': '0.071', 'Colon enteroendocrine cells': '0.928', 'Enteric glia cells': '0.438', 'Mitotic cells (Colon)': '-0.047', 'Mitotic cells (Heart)': '0.376', 'Podocytes': '-0.187', 'Ascending Loop of Henle cells': '0.674', 'Intercalated cells': '0.040', 'Cholangiocyte': '0.225', 'NK-cells (Liver)': '-0.007', 'Respiratory ciliated cells': '0.111', 'Mitotic cells (Lung)': '-0.053', 'NK-cells (Lung)': '0.179', 'B-cells (Lung)': '-0.068', 'Alpha cells': '0.649', 'Beta cells': '0.654', 'Prostate glandular cells': '-0.074', 'Prostate basal glandular cells': '0.024', 'Urothelial cells': '0.026', 'Keratinocyte (other)': '-0.127', 'Keratinocyte (granular)': '-0.023', 'Hair cortex cells': '0.149', 'Inner root sheath cells': '0.082', 'Outer root sheath cells': '0.245', 'Sebaceous gland cells': '0.130', 'Eccrine sweat gland cells': '0.224', 'Adipocytes (Skin)': '0.174', 'Mitotic cells (Skin)': '0.097', 'Parietal cells': '-0.581', 'Chief cells': '-0.317', 'Gastric mucous cells': '-0.516', 'Gastric enteroendocrine cells': '-0.154', 'Mitotic cells (Stomach)': '-0.134', 'Parafollicular cells': '0.208', 'Thyroid glandular cells': '0.351', 'Mitotic cells (Thyroid)': '0.024', 'Adrenal cortex cells': '0.322', 'Adrenal medulla cells': '0.527', 'Mitotic cells (Adrenal gland)': '0.272', 'Minor salivary glandular cells': '0.122', 'Minor salivary gland ductal cells': '0.354', 'Minor salivary gland basal cells': '0.095', 'Mitotic cells (Minor salivary gland)': '0.085', 'Adipocytes (Minor salivary gland)': '0.297', 'Somatotropes': '0.236', 'Lactotropes': '0.405', 'Gonadotropes': '0.110', 'Corticotropes': '0.432', 'Thyrotropes': '0.259', 'Undifferentiated cells (Pituitary gland)': '-0.366', 'Mitotic cells (Spleen)': '-0.263', 'Platelets': '-0.234', 'Erythrocytes': '-0.168', 'Hematopoietic stem cells': '-0.181', 'B-cells (Spleen)': '0.116', 'NK-cells (Spleen)': '0.206', 'Amygdala excitatory': '158.1', 'Cerebellar inhibitory': '245.3', 'Cge interneuron': '205.9', 'Deep-layer corticothalamic and 6b': '176.6', 'Deep-layer intratelencephalic': '185.6', 'Deep-layer near-projecting': '185.5', 'Eccentric medium spiny neuron': '153.8', 'Hippocampal ca1-3': '166.5', 'Hippocampal ca4': '153.1', 'Hippocampal dentate gyrus': '142.6', 'Lamp5-lhx6 and chandelier': '238.9', 'Lower rhombic lip': '136.1', 'Mammillary body': '164.6', 'Medium spiny neuron': '99.8', 'Mge interneuron': '200.3', 'Midbrain-derived inhibitory': '210.8', 'Miscellaneous': '185.7', 'Splatter': '148.3', 'Thalamic excitatory': '170.2', 'Upper rhombic lip': '165.8', 'Upper-layer intratelencephalic': '174.5', 'Astrocyte': '25.6', 'Bergmann glia': '34.0', 'Central nervous system macrophage': '16.4', 'Choroid plexus epithelial cell': '11.9', 'Committed oligodendrocyte precursor': '51.5', 'Ependymal cell': '13.0', 'Oligodendrocyte': '41.3', 'Oligodendrocyte precursor cell': '46.4', 'Endothelial cell': '14.2', 'Pericyte': '27.2', 'Vascular associated smooth muscle cell': '22.6', 'Fibroblast': '15.1', 'Leukocyte': '11.2', 'Basophil': '1.2', 'Eosinophil': '0.1', 'Neutrophil': '1.4', 'Classical monocyte': '0.7', 'Non-classical monocyte': '0.9', 'Intermediate monocyte': '1.1', 'T-reg': '1.2', 'GdT-cell': '0.0', 'MAIT T-cell': '0.3', 'Memory CD4 T-cell': '0.0', 'Naive CD4 T-cell': '1.0', 'Memory CD8 T-cell': '0.2', 'Naive CD8 T-cell': '1.0', 'Memory B-cell': '0.2', 'Naive B-cell': '0.8', 'Plasmacytoid DC': '1.5', 'Myeloid DC': '1.4', 'NK-cell': '0.6', 'Total PBMC': '0.8', 'Vd2 gdTCR': '0.5', 'Memory CD4 T-cell Th1\\/Th17': '0.5', 'Memory CD4 T-cell Th17': '0.8', 'Memory CD4 T-cell Th2': '0.7', 'Non-Vd2 gdTCR': '0.2', 'Memory CD4 T-cell Th1': '0.6', 'Memory CD4 T-cell TFH': '1.3', 'Terminal effector memory CD4 T-cell': '0.7', 'Central memory CD8 T-cell': '0.9', 'Effector memory CD8 T-cell': '0.3', 'Terminal effector memory CD8 T-cell': '0.3', 'Non-switched memory B-cell': '0.6', 'Plasmablast': '0.4', 'Switched memory B-cell': '0.7', 'Exhausted memory B-cell': '0.1', 'Progenitor cell': '2.0', 'Memory T-reg': '2.0', 'Naive CD4 T-cell activated': '0.8', 'Naive CD8 T-cell activated': '0.7', 'Naive T-reg': '1.9'}
null
{'Adipose Tissue': 2.774092857142857, 'Adrenal Gland': 13.91348527131783, 'Bladder': 2.0017619047619046, 'Blood': 1.1581048439181916, 'Blood Vessel': 6.120213483146067, 'Brain': 213.8520492051476, 'Breast': 2.5922172113289763, 'Cervix Uteri': 2.899347368421053, 'Colon': 8.419663671373556, 'Esophagus': 3.5407353633217995, 'Fallopian Tube': 2.8013333333333335, 'Heart': 1.4808163763066202, 'Kidney': 2.419978651685393, 'Liver': 0.3877515486725664, 'Lung': 4.524702422145328, 'Muscle': 0.6563473225404733, 'Nerve': 8.080247172859451, 'Ovary': 2.662568333333333, 'Pancreas': 3.444146341463415, 'Pituitary': 143.6155477031802, 'Prostate': 2.335274693877551, 'Salivary Gland': 1.434104938271605, 'Skin': 1.6590567164179104, 'Small Intestine': 8.389946524064172, 'Spleen': 2.47088755186722, 'Stomach': 5.224543175487465, 'Testis': 3.0306592797783933, 'Thyroid': 3.8134529862174578, 'Uterus': 3.126231690140845, 'Vagina': 3.6185339743589746}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
77.170575
0.499712
2,331
O60260
P09936
25403879
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
UCHL1
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
Homo sapiens
Cytoplasm, Endoplasmic reticulum membrane
Group enriched (brain, pituitary gland)
{'Ciliated cells': '5.9', 'Basal respiratory cells': '1.0', 'Club cells': '1.2', 'Ionocytes': '1.5', 'Mucus glandular cells': '0.9', 'Serous glandular cells': '0.4', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '0.0', 'Paneth cells': '0.0', 'Distal enterocytes': '0.3', 'Intestinal goblet cells': '0.0', 'Exocrine glandular cells': '-0.404', 'Basal prostatic cells': '1.1', 'Prostatic glandular cells': '2.5', 'Breast glandular cells': '-0.426', 'Breast myoepithelial cells': '-0.302', 'Glandular and luminal cells': '0.5', 'Secretory cells': '1.0', 'Basal keratinocytes': '2.5', 'Suprabasal keratinocytes': '1.3', 'Basal squamous epithelial cells': '0.2', 'Squamous epithelial cells': '0.6', 'Alveolar cells type 1': '-0.443', 'Alveolar cells type 2': '-0.045', 'Salivary duct cells': '1.0', 'Ductal cells': '0.427', 'Hepatocytes': '0.141', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.063', 'Distal tubular cells': '227.4', 'Collecting duct cells': '130.3', 'Mesothelial cells': '0.218', 'Sertoli cells': '0.415', 'Granulosa cells': '66.0', 'Enteroendocrine cells': '1.2', 'Pancreatic endocrine cells': '122.3', 'Leydig cells': '0.546', 'Excitatory neurons': '142.2', 'Inhibitory neurons': '113.4', 'Cone photoreceptor cells': '11.9', 'Rod photoreceptor cells': '23.4', 'Bipolar cells': '32.2', 'Horizontal cells': '177.5', 'Astrocytes': '27.6', 'Oligodendrocyte precursor cells': '52.4', 'Oligodendrocytes': '50.8', 'Microglial cells': '34.0', 'Muller glia cells': '16.2', 'Schwann cells': '0.378', 'Spermatogonia': '0.627', 'Spermatocytes': '0.134', 'Early spermatids': '-0.472', 'Late spermatids': '-0.527', 'Oocytes': '1677.8', 'Cytotrophoblasts': '3.5', 'Syncytiotrophoblasts': '1.6', 'Extravillous trophoblasts': '0.6', 'Endothelial cells': '2.6', 'Lymphatic endothelial cells': '6.0', 'Cardiomyocytes': '0.342', 'Skeletal myocytes': '0.074', 'Smooth muscle cells': '8.5', 'Adipocytes': '0.7', 'Melanocytes': '0.156', 'Fibroblasts': '37.9', 'Peritubular cells': '0.425', 'Endometrial stromal cells': '10.0', 'Ovarian stromal cells': '67.2', 'Undifferentiated cells': '0.0', 'T-cells': '0.7', 'B-cells': '0.5', 'Plasma cells': '18.4', 'Nk-cells': '0.0', 'Granulocytes': '0.2', 'Monocytes': '0.0', 'Macrophages': '3.3', 'Hofbauer cells': '3.6', 'Kupffer cells': '0.0', 'Dendritic cells': '0.0', 'Langerhans cells': '0.150', 'Erythroid cells': '0.022', 'Adipocytes (Subcutaneous)': '0.339', 'Adipocytes (Visceral)': '0.161', 'Breast glandular cells (progenitors)': '-0.347', 'Adipocytes (Breast)': '0.501', 'Colon enterocytes': '-0.004', 'Colon enteroendocrine cells': '0.932', 'Enteric glia cells': '0.535', 'Mitotic cells (Colon)': '-0.128', 'Mitotic cells (Heart)': '0.450', 'Podocytes': '-0.078', 'Ascending Loop of Henle cells': '0.457', 'Intercalated cells': '-0.071', 'Cholangiocyte': '0.471', 'NK-cells (Liver)': '-0.261', 'Respiratory ciliated cells': '-0.033', 'Mitotic cells (Lung)': '0.382', 'NK-cells (Lung)': '-0.194', 'B-cells (Lung)': '-0.032', 'Alpha cells': '0.633', 'Beta cells': '0.765', 'Prostate glandular cells': '-0.362', 'Prostate basal glandular cells': '-0.340', 'Urothelial cells': '-0.217', 'Keratinocyte (other)': '-0.192', 'Keratinocyte (granular)': '-0.193', 'Hair cortex cells': '0.259', 'Inner root sheath cells': '0.260', 'Outer root sheath cells': '0.350', 'Sebaceous gland cells': '0.064', 'Eccrine sweat gland cells': '0.178', 'Adipocytes (Skin)': '0.138', 'Mitotic cells (Skin)': '0.200', 'Parietal cells': '-0.736', 'Chief cells': '-0.573', 'Gastric mucous cells': '-0.623', 'Gastric enteroendocrine cells': '-0.419', 'Mitotic cells (Stomach)': '-0.197', 'Parafollicular cells': '0.100', 'Thyroid glandular cells': '0.166', 'Mitotic cells (Thyroid)': '0.086', 'Adrenal cortex cells': '0.262', 'Adrenal medulla cells': '0.456', 'Mitotic cells (Adrenal gland)': '0.445', 'Minor salivary glandular cells': '0.309', 'Minor salivary gland ductal cells': '-0.077', 'Minor salivary gland basal cells': '0.133', 'Mitotic cells (Minor salivary gland)': '0.394', 'Adipocytes (Minor salivary gland)': '0.245', 'Somatotropes': '0.136', 'Lactotropes': '0.359', 'Gonadotropes': '-0.041', 'Corticotropes': '0.214', 'Thyrotropes': '0.241', 'Undifferentiated cells (Pituitary gland)': '-0.205', 'Mitotic cells (Spleen)': '0.495', 'Platelets': '0.068', 'Erythrocytes': '0.118', 'Hematopoietic stem cells': '0.110', 'B-cells (Spleen)': '-0.160', 'NK-cells (Spleen)': '-0.291', 'Amygdala excitatory': '254.6', 'Cerebellar inhibitory': '171.8', 'Cge interneuron': '204.0', 'Deep-layer corticothalamic and 6b': '293.6', 'Deep-layer intratelencephalic': '291.7', 'Deep-layer near-projecting': '253.7', 'Eccentric medium spiny neuron': '232.9', 'Hippocampal ca1-3': '272.5', 'Hippocampal ca4': '451.7', 'Hippocampal dentate gyrus': '216.8', 'Lamp5-lhx6 and chandelier': '231.6', 'Lower rhombic lip': '381.6', 'Mammillary body': '242.6', 'Medium spiny neuron': '204.8', 'Mge interneuron': '232.7', 'Midbrain-derived inhibitory': '203.5', 'Miscellaneous': '274.7', 'Splatter': '320.1', 'Thalamic excitatory': '400.1', 'Upper rhombic lip': '79.8', 'Upper-layer intratelencephalic': '215.8', 'Astrocyte': '33.2', 'Bergmann glia': '78.8', 'Central nervous system macrophage': '39.3', 'Choroid plexus epithelial cell': '25.8', 'Committed oligodendrocyte precursor': '77.0', 'Ependymal cell': '118.3', 'Oligodendrocyte': '79.6', 'Oligodendrocyte precursor cell': '62.4', 'Endothelial cell': '31.8', 'Pericyte': '37.4', 'Vascular associated smooth muscle cell': '49.4', 'Fibroblast': '51.0', 'Leukocyte': '30.3', 'Basophil': '0.0', 'Eosinophil': '0.0', 'Neutrophil': '0.0', 'Classical monocyte': '0.0', 'Non-classical monocyte': '0.0', 'Intermediate monocyte': '0.0', 'T-reg': '0.0', 'GdT-cell': '0.0', 'MAIT T-cell': '0.0', 'Memory CD4 T-cell': '0.0', 'Naive CD4 T-cell': '0.0', 'Memory CD8 T-cell': '0.0', 'Naive CD8 T-cell': '0.0', 'Memory B-cell': '0.8', 'Naive B-cell': '0.0', 'Plasmacytoid DC': '0.0', 'Myeloid DC': '0.0', 'NK-cell': '0.0', 'Total PBMC': '0.2', 'Vd2 gdTCR': '0.0', 'Memory CD4 T-cell Th1\\/Th17': '0.0', 'Memory CD4 T-cell Th17': '0.0', 'Memory CD4 T-cell Th2': '0.0', 'Non-Vd2 gdTCR': '0.0', 'Memory CD4 T-cell Th1': '0.0', 'Memory CD4 T-cell TFH': '0.0', 'Terminal effector memory CD4 T-cell': '0.0', 'Central memory CD8 T-cell': '0.0', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '0.0', 'Non-switched memory B-cell': '0.0', 'Plasmablast': '7.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.2', 'Progenitor cell': '3.8', 'Memory T-reg': '0.0', 'Naive CD4 T-cell activated': '0.0', 'Naive CD8 T-cell activated': '0.1', 'Naive T-reg': '0.0'}
2ETL, 2LEN, 3IFW, 3IRT, 3KVF, 3KW5, 4DM9, 4JKJ, 7ZM0, 8DY8, 8EDE, 8PW1, 8XI7
{'Adipose Tissue': 51.706907807308966, 'Adrenal Gland': 59.691600775193805, 'Bladder': 65.70285714285714, 'Blood': 7.462225791173305, 'Blood Vessel': 79.85514531835206, 'Brain': 628.7773796366389, 'Breast': 26.281316557734204, 'Cervix Uteri': 36.69021052631579, 'Colon': 70.85547394094993, 'Esophagus': 24.46132456747405, 'Fallopian Tube': 12.42477777777778, 'Heart': 18.041137282229965, 'Kidney': 58.8208988764045, 'Liver': 2.147167787610619, 'Lung': 18.328262975778543, 'Muscle': 23.44805105853051, 'Nerve': 92.08342487883684, 'Ovary': 91.28861111111112, 'Pancreas': 8.686917987804877, 'Pituitary': 670.2939929328622, 'Prostate': 29.285718367346934, 'Salivary Gland': 7.584592592592592, 'Skin': 37.601221006080706, 'Small Intestine': 34.59463101604278, 'Spleen': 5.599460580912863, 'Stomach': 24.34014428969359, 'Testis': 54.46008310249307, 'Thyroid': 28.343027565084224, 'Uterus': 28.14147887323944, 'Vagina': 65.12390384615385}
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[81.34, 88.55, 91.54, 90.6, 88.11, 88.45, 86.78, 87.17, 91.69, 95.17, 95.58, 94.78, 95.96, 97.06, 96.78, 96.84, 96.92, 96.97, 97.34, 98.05, 97.73, 97.34, 94.75, 89.26, 92.26, 97.57, 97.42, 97.62, 97.33, 97.03, 96.8, 94.83, 94.35, 94.99, 93.93, 89.74, 90.89, 92.61, 94.77, 92.75, 92.86, 95.98, 95.45, 93.86, 96.25, 97.28, 98.0, 98.39, 98.25, 97.59, 96.16, 93.16, 91.08, 88.44, 85.47, 87.29, 87.02, 88.23, 88.33, 88.62, 90.36, 90.67, 91.71, 91.37, 92.47, 91.71, 90.72, 91.13, 91.96, 91.37, 84.36, 79.91, 88.17, 87.55, 95.02, 96.38, 95.64, 97.24, 98.25, 98.64, 98.33, 98.1, 97.47, 95.51, 94.65, 93.24, 90.52, 88.74, 93.03, 91.42, 92.32, 95.41, 96.61, 96.13, 97.08, 98.13, 98.34, 98.13, 98.05, 98.32, 98.45, 97.91, 96.67, 95.2, 95.3, 96.4, 95.3, 97.67, 96.48, 96.06, 95.48, 98.12, 98.2, 98.35, 98.11, 98.31, 98.67, 98.44, 97.92, 98.11, 98.47, 97.71, 97.18, 98.2, 97.8, 98.07, 97.95, 98.43, 98.66, 98.11, 98.12, 98.3, 98.19, 97.5, 96.99, 97.57, 97.19, 97.86, 98.0, 97.21, 97.08, 97.18, 96.44, 95.19, 96.1, 95.81, 92.72, 91.94, 92.79, 84.74, 81.41, 75.2, 71.13, 70.19, 68.91, 68.31, 68.59, 66.16, 77.51, 84.23, 88.23, 89.63, 93.83, 97.94, 98.49, 98.15, 98.27, 98.09, 96.34, 97.11, 98.16, 98.43, 98.48, 97.89, 97.92, 95.75, 94.81, 92.38, 93.84, 94.18, 95.82, 97.19, 96.98, 97.08, 96.3, 95.86, 97.53, 98.08, 96.96, 93.61, 94.93, 96.52, 97.84, 97.1, 97.22, 98.01, 98.2, 97.34, 97.21, 96.4, 95.62, 93.57, 92.31, 89.03, 87.65, 88.86, 88.44, 85.18, 77.56, 82.26, 87.19, 86.38, 89.93, 91.91, 93.71, 96.55, 97.54, 97.76, 98.03, 97.51, 95.48, 83.2, 66.44]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
93.461973
0.309731
2,593
O60260
P0DMV8
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
HSPA1A
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
Homo sapiens
Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Secreted
Low tissue specificity
{'Ciliated cells': '504.4', 'Basal respiratory cells': '119.8', 'Club cells': '313.4', 'Ionocytes': '138.4', 'Mucus glandular cells': '349.5', 'Serous glandular cells': '247.6', 'Gastric mucus-secreting cells': '494.0', 'Proximal enterocytes': '66.2', 'Paneth cells': '377.2', 'Distal enterocytes': '918.7', 'Intestinal goblet cells': '356.5', 'Exocrine glandular cells': '-0.145', 'Basal prostatic cells': '555.1', 'Prostatic glandular cells': '695.7', 'Breast glandular cells': '0.103', 'Breast myoepithelial cells': '0.125', 'Glandular and luminal cells': '791.7', 'Secretory cells': '759.2', 'Basal keratinocytes': '367.0', 'Suprabasal keratinocytes': '436.7', 'Basal squamous epithelial cells': '853.0', 'Squamous epithelial cells': '979.7', 'Alveolar cells type 1': '0.078', 'Alveolar cells type 2': '-0.644', 'Salivary duct cells': '209.6', 'Ductal cells': '0.218', 'Hepatocytes': '0.156', 'Cholangiocytes': '57.2', 'Proximal tubular cells': '0.073', 'Distal tubular cells': '18.4', 'Collecting duct cells': '140.0', 'Mesothelial cells': '0.217', 'Sertoli cells': '0.011', 'Granulosa cells': '1619.2', 'Enteroendocrine cells': '330.5', 'Pancreatic endocrine cells': '44.1', 'Leydig cells': '0.071', 'Excitatory neurons': '9.4', 'Inhibitory neurons': '10.9', 'Cone photoreceptor cells': '579.4', 'Rod photoreceptor cells': '690.3', 'Bipolar cells': '362.3', 'Horizontal cells': '303.4', 'Astrocytes': '405.3', 'Oligodendrocyte precursor cells': '16.0', 'Oligodendrocytes': '192.8', 'Microglial cells': '380.2', 'Muller glia cells': '712.2', 'Schwann cells': '0.015', 'Spermatogonia': '0.036', 'Spermatocytes': '-0.071', 'Early spermatids': '-0.106', 'Late spermatids': '-0.089', 'Oocytes': '34.6', 'Cytotrophoblasts': '54.7', 'Syncytiotrophoblasts': '122.0', 'Extravillous trophoblasts': '166.0', 'Endothelial cells': '1185.9', 'Lymphatic endothelial cells': '1082.8', 'Cardiomyocytes': '0.081', 'Skeletal myocytes': '0.312', 'Smooth muscle cells': '1253.1', 'Adipocytes': '1232.4', 'Melanocytes': '0.034', 'Fibroblasts': '785.5', 'Peritubular cells': '0.121', 'Endometrial stromal cells': '454.2', 'Ovarian stromal cells': '1158.4', 'Undifferentiated cells': '363.5', 'T-cells': '970.6', 'B-cells': '394.7', 'Plasma cells': '1272.7', 'Nk-cells': '54.4', 'Granulocytes': '1844.0', 'Monocytes': '613.1', 'Macrophages': '2004.5', 'Hofbauer cells': '283.5', 'Kupffer cells': '284.0', 'Dendritic cells': '62.1', 'Langerhans cells': '0.145', 'Erythroid cells': '0.198', 'Adipocytes (Subcutaneous)': '-0.219', 'Adipocytes (Visceral)': '-0.357', 'Breast glandular cells (progenitors)': '0.096', 'Adipocytes (Breast)': '-0.161', 'Colon enterocytes': '-0.222', 'Colon enteroendocrine cells': '0.172', 'Enteric glia cells': '0.502', 'Mitotic cells (Colon)': '-0.178', 'Mitotic cells (Heart)': '0.090', 'Podocytes': '0.159', 'Ascending Loop of Henle cells': '-0.117', 'Intercalated cells': '0.125', 'Cholangiocyte': '0.057', 'NK-cells (Liver)': '0.264', 'Respiratory ciliated cells': '0.105', 'Mitotic cells (Lung)': '-0.176', 'NK-cells (Lung)': '0.451', 'B-cells (Lung)': '0.266', 'Alpha cells': '0.146', 'Beta cells': '0.043', 'Prostate glandular cells': '-0.110', 'Prostate basal glandular cells': '-0.221', 'Urothelial cells': '0.046', 'Keratinocyte (other)': '0.293', 'Keratinocyte (granular)': '0.058', 'Hair cortex cells': '-0.163', 'Inner root sheath cells': '-0.103', 'Outer root sheath cells': '-0.074', 'Sebaceous gland cells': '-0.065', 'Eccrine sweat gland cells': '-0.128', 'Adipocytes (Skin)': '-0.242', 'Mitotic cells (Skin)': '0.027', 'Parietal cells': '-0.613', 'Chief cells': '-0.433', 'Gastric mucous cells': '-0.508', 'Gastric enteroendocrine cells': '-0.316', 'Mitotic cells (Stomach)': '-0.258', 'Parafollicular cells': '0.036', 'Thyroid glandular cells': '0.170', 'Mitotic cells (Thyroid)': '0.065', 'Adrenal cortex cells': '0.273', 'Adrenal medulla cells': '-0.098', 'Mitotic cells (Adrenal gland)': '-0.270', 'Minor salivary glandular cells': '0.043', 'Minor salivary gland ductal cells': '-0.084', 'Minor salivary gland basal cells': '0.344', 'Mitotic cells (Minor salivary gland)': '0.259', 'Adipocytes (Minor salivary gland)': '0.057', 'Somatotropes': '-0.220', 'Lactotropes': '0.014', 'Gonadotropes': '0.154', 'Corticotropes': '0.026', 'Thyrotropes': '0.157', 'Undifferentiated cells (Pituitary gland)': '0.180', 'Mitotic cells (Spleen)': '-0.093', 'Platelets': '-0.237', 'Erythrocytes': '0.079', 'Hematopoietic stem cells': '-0.096', 'B-cells (Spleen)': '-0.058', 'NK-cells (Spleen)': '0.120', 'Amygdala excitatory': '9.8', 'Cerebellar inhibitory': '22.4', 'Cge interneuron': '19.0', 'Deep-layer corticothalamic and 6b': '10.6', 'Deep-layer intratelencephalic': '9.6', 'Deep-layer near-projecting': '13.8', 'Eccentric medium spiny neuron': '15.3', 'Hippocampal ca1-3': '8.1', 'Hippocampal ca4': '24.5', 'Hippocampal dentate gyrus': '16.1', 'Lamp5-lhx6 and chandelier': '19.1', 'Lower rhombic lip': '18.2', 'Mammillary body': '8.5', 'Medium spiny neuron': '10.4', 'Mge interneuron': '12.3', 'Midbrain-derived inhibitory': '10.6', 'Miscellaneous': '13.2', 'Splatter': '16.6', 'Thalamic excitatory': '15.0', 'Upper rhombic lip': '23.0', 'Upper-layer intratelencephalic': '8.5', 'Astrocyte': '667.4', 'Bergmann glia': '350.7', 'Central nervous system macrophage': '1466.5', 'Choroid plexus epithelial cell': '22.4', 'Committed oligodendrocyte precursor': '81.0', 'Ependymal cell': '457.3', 'Oligodendrocyte': '293.4', 'Oligodendrocyte precursor cell': '43.6', 'Endothelial cell': '1181.6', 'Pericyte': '99.1', 'Vascular associated smooth muscle cell': '506.6', 'Fibroblast': '131.6', 'Leukocyte': '483.6', 'Basophil': '23.9', 'Eosinophil': '3.2', 'Neutrophil': '77.9', 'Classical monocyte': '16.2', 'Non-classical monocyte': '13.6', 'Intermediate monocyte': '14.0', 'T-reg': '4.1', 'GdT-cell': '1.1', 'MAIT T-cell': '0.2', 'Memory CD4 T-cell': '1.6', 'Naive CD4 T-cell': '1.4', 'Memory CD8 T-cell': '1.4', 'Naive CD8 T-cell': '1.2', 'Memory B-cell': '0.6', 'Naive B-cell': '0.6', 'Plasmacytoid DC': '1.8', 'Myeloid DC': '5.5', 'NK-cell': '5.3', 'Total PBMC': '8.7', 'Vd2 gdTCR': '3.6', 'Memory CD4 T-cell Th1\\/Th17': '6.3', 'Memory CD4 T-cell Th17': '7.2', 'Memory CD4 T-cell Th2': '8.4', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '8.0', 'Memory CD4 T-cell TFH': '7.7', 'Terminal effector memory CD4 T-cell': '10.3', 'Central memory CD8 T-cell': '2.3', 'Effector memory CD8 T-cell': '1.7', 'Terminal effector memory CD8 T-cell': '5.2', 'Non-switched memory B-cell': '0.5', 'Plasmablast': '0.0', 'Switched memory B-cell': '2.1', 'Exhausted memory B-cell': '4.3', 'Progenitor cell': '6.5', 'Memory T-reg': '12.0', 'Naive CD4 T-cell activated': '79.2', 'Naive CD8 T-cell activated': '78.0', 'Naive T-reg': '4.2'}
1HJO, 1S3X, 1XQS, 2E88, 2E8A, 2LMG, 3A8Y, 3ATU, 3ATV, 3AY9, 3D2E, 3D2F, 3JXU, 3LOF, 3Q49, 4IO8, 4J8F, 4PO2, 4WV5, 4WV7, 5AQW, 5AQX, 5AQY, 5AQZ, 5AR0, 5BN8, 5BN9, 5BPL, 5BPM, 5BPN, 5GJJ, 5MKR, 5MKS, 5XI9, 5XIR, 6FHK, 6G3R, 6G3S, 6JPV, 6K39, 6ZYI, 7FGM, 7KW7, 7Q4R
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
88.758175
0.315413
1,068
O60260
P10415
20889974, UNIPROT
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
BCL2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Homo sapiens
Mitochondrion outer membrane, Nucleus membrane, Endoplasmic reticulum membrane, Cytoplasm
Low tissue specificity
{'Ciliated cells': '6.2', 'Basal respiratory cells': '2.0', 'Club cells': '20.6', 'Ionocytes': '5.9', 'Mucus glandular cells': '11.6', 'Serous glandular cells': '9.3', 'Gastric mucus-secreting cells': '4.7', 'Proximal enterocytes': '0.4', 'Paneth cells': '5.2', 'Distal enterocytes': '3.2', 'Intestinal goblet cells': '11.6', 'Exocrine glandular cells': '-0.444', 'Basal prostatic cells': '29.0', 'Prostatic glandular cells': '6.8', 'Breast glandular cells': '0.433', 'Breast myoepithelial cells': '0.327', 'Glandular and luminal cells': '22.7', 'Secretory cells': '30.3', 'Basal keratinocytes': '16.6', 'Suprabasal keratinocytes': '14.5', 'Basal squamous epithelial cells': '10.6', 'Squamous epithelial cells': '5.6', 'Alveolar cells type 1': '0.156', 'Alveolar cells type 2': '-0.484', 'Salivary duct cells': '25.9', 'Ductal cells': '0.692', 'Hepatocytes': '0.133', 'Cholangiocytes': '21.0', 'Proximal tubular cells': '0.157', 'Distal tubular cells': '12.3', 'Collecting duct cells': '7.8', 'Mesothelial cells': '0.074', 'Sertoli cells': '0.638', 'Granulosa cells': '44.1', 'Enteroendocrine cells': '10.2', 'Pancreatic endocrine cells': '3.4', 'Leydig cells': '0.551', 'Excitatory neurons': '58.5', 'Inhibitory neurons': '97.7', 'Cone photoreceptor cells': '0.0', 'Rod photoreceptor cells': '0.0', 'Bipolar cells': '1.2', 'Horizontal cells': '6.3', 'Astrocytes': '257.6', 'Oligodendrocyte precursor cells': '71.7', 'Oligodendrocytes': '52.8', 'Microglial cells': '84.1', 'Muller glia cells': '18.1', 'Schwann cells': '0.623', 'Spermatogonia': '0.458', 'Spermatocytes': '0.023', 'Early spermatids': '-0.523', 'Late spermatids': '-0.693', 'Oocytes': '0.7', 'Cytotrophoblasts': '14.0', 'Syncytiotrophoblasts': '50.7', 'Extravillous trophoblasts': '0.4', 'Endothelial cells': '4.3', 'Lymphatic endothelial cells': '11.8', 'Cardiomyocytes': '0.543', 'Skeletal myocytes': '0.651', 'Smooth muscle cells': '22.2', 'Adipocytes': '6.4', 'Melanocytes': '0.188', 'Fibroblasts': '24.5', 'Peritubular cells': '0.573', 'Endometrial stromal cells': '9.4', 'Ovarian stromal cells': '23.9', 'Undifferentiated cells': '12.3', 'T-cells': '102.3', 'B-cells': '98.1', 'Plasma cells': '62.8', 'Nk-cells': '46.0', 'Granulocytes': '43.5', 'Monocytes': '25.6', 'Macrophages': '35.6', 'Hofbauer cells': '9.1', 'Kupffer cells': '15.4', 'Dendritic cells': '12.1', 'Langerhans cells': '0.311', 'Erythroid cells': '0.057', 'Adipocytes (Subcutaneous)': '0.585', 'Adipocytes (Visceral)': '0.394', 'Breast glandular cells (progenitors)': '0.193', 'Adipocytes (Breast)': '-0.112', 'Colon enterocytes': '-0.098', 'Colon enteroendocrine cells': '0.494', 'Enteric glia cells': '0.727', 'Mitotic cells (Colon)': '-0.133', 'Mitotic cells (Heart)': '0.478', 'Podocytes': '-0.071', 'Ascending Loop of Henle cells': '0.559', 'Intercalated cells': '0.082', 'Cholangiocyte': '0.538', 'NK-cells (Liver)': '0.083', 'Respiratory ciliated cells': '0.106', 'Mitotic cells (Lung)': '-0.135', 'NK-cells (Lung)': '0.430', 'B-cells (Lung)': '0.340', 'Alpha cells': '0.393', 'Beta cells': '0.220', 'Prostate glandular cells': '-0.291', 'Prostate basal glandular cells': '0.183', 'Urothelial cells': '0.279', 'Keratinocyte (other)': '0.290', 'Keratinocyte (granular)': '-0.059', 'Hair cortex cells': '-0.083', 'Inner root sheath cells': '-0.054', 'Outer root sheath cells': '0.064', 'Sebaceous gland cells': '-0.045', 'Eccrine sweat gland cells': '0.222', 'Adipocytes (Skin)': '-0.023', 'Mitotic cells (Skin)': '0.337', 'Parietal cells': '-0.726', 'Chief cells': '-0.650', 'Gastric mucous cells': '-0.614', 'Gastric enteroendocrine cells': '-0.471', 'Mitotic cells (Stomach)': '-0.232', 'Parafollicular cells': '0.188', 'Thyroid glandular cells': '0.734', 'Mitotic cells (Thyroid)': '-0.096', 'Adrenal cortex cells': '0.152', 'Adrenal medulla cells': '0.457', 'Mitotic cells (Adrenal gland)': '0.133', 'Minor salivary glandular cells': '0.298', 'Minor salivary gland ductal cells': '0.469', 'Minor salivary gland basal cells': '0.048', 'Mitotic cells (Minor salivary gland)': '0.072', 'Adipocytes (Minor salivary gland)': '0.408', 'Somatotropes': '-0.243', 'Lactotropes': '-0.096', 'Gonadotropes': '0.044', 'Corticotropes': '-0.236', 'Thyrotropes': '0.110', 'Undifferentiated cells (Pituitary gland)': '0.745', 'Mitotic cells (Spleen)': '-0.102', 'Platelets': '-0.118', 'Erythrocytes': '-0.106', 'Hematopoietic stem cells': '-0.192', 'B-cells (Spleen)': '0.493', 'NK-cells (Spleen)': '0.362', 'Amygdala excitatory': '118.2', 'Cerebellar inhibitory': '56.6', 'Cge interneuron': '172.1', 'Deep-layer corticothalamic and 6b': '116.8', 'Deep-layer intratelencephalic': '76.8', 'Deep-layer near-projecting': '235.3', 'Eccentric medium spiny neuron': '109.1', 'Hippocampal ca1-3': '104.9', 'Hippocampal ca4': '17.0', 'Hippocampal dentate gyrus': '34.4', 'Lamp5-lhx6 and chandelier': '151.5', 'Lower rhombic lip': '15.7', 'Mammillary body': '41.6', 'Medium spiny neuron': '45.8', 'Mge interneuron': '99.9', 'Midbrain-derived inhibitory': '117.9', 'Miscellaneous': '126.9', 'Splatter': '90.8', 'Thalamic excitatory': '134.9', 'Upper rhombic lip': '27.0', 'Upper-layer intratelencephalic': '168.1', 'Astrocyte': '797.6', 'Bergmann glia': '402.4', 'Central nervous system macrophage': '455.4', 'Choroid plexus epithelial cell': '97.8', 'Committed oligodendrocyte precursor': '55.0', 'Ependymal cell': '353.2', 'Oligodendrocyte': '159.3', 'Oligodendrocyte precursor cell': '112.4', 'Endothelial cell': '13.2', 'Pericyte': '624.4', 'Vascular associated smooth muscle cell': '377.4', 'Fibroblast': '117.6', 'Leukocyte': '1345.4', 'Basophil': '34.1', 'Eosinophil': '0.0', 'Neutrophil': '0.2', 'Classical monocyte': '4.0', 'Non-classical monocyte': '0.8', 'Intermediate monocyte': '1.0', 'T-reg': '31.7', 'GdT-cell': '1.9', 'MAIT T-cell': '23.7', 'Memory CD4 T-cell': '6.3', 'Naive CD4 T-cell': '95.1', 'Memory CD8 T-cell': '3.4', 'Naive CD8 T-cell': '73.1', 'Memory B-cell': '5.4', 'Naive B-cell': '79.6', 'Plasmacytoid DC': '0.5', 'Myeloid DC': '5.6', 'NK-cell': '25.4', 'Total PBMC': '8.3', 'Vd2 gdTCR': '5.6', 'Memory CD4 T-cell Th1\\/Th17': '117.8', 'Memory CD4 T-cell Th17': '96.2', 'Memory CD4 T-cell Th2': '68.8', 'Non-Vd2 gdTCR': '14.6', 'Memory CD4 T-cell Th1': '80.7', 'Memory CD4 T-cell TFH': '92.7', 'Terminal effector memory CD4 T-cell': '16.4', 'Central memory CD8 T-cell': '26.2', 'Effector memory CD8 T-cell': '14.9', 'Terminal effector memory CD8 T-cell': '9.2', 'Non-switched memory B-cell': '32.0', 'Plasmablast': '8.8', 'Switched memory B-cell': '23.8', 'Exhausted memory B-cell': '19.9', 'Progenitor cell': '4.6', 'Memory T-reg': '58.7', 'Naive CD4 T-cell activated': '144.4', 'Naive CD8 T-cell activated': '140.3', 'Naive T-reg': '133.0'}
1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG, 5JSN, 5VAU, 5VAX, 5VAY, 6GL8, 6IWB, 6O0K, 6O0L, 6O0M, 6O0O, 6O0P, 7LHB, 7Y90, 7YA5, 8FY1, 8FY2, 8HLL, 8HLM, 8HLN, 8HOG, 8HOH, 8HOI, 8IQL, 8U27
{'Adipose Tissue': 10.18636046511628, 'Adrenal Gland': 0.7040096899224806, 'Bladder': 7.231, 'Blood': 12.855593606027988, 'Blood Vessel': 8.182552059925094, 'Brain': 3.756474110522331, 'Breast': 11.74893899782135, 'Cervix Uteri': 17.16536842105263, 'Colon': 6.847372272143774, 'Esophagus': 6.077867958477509, 'Fallopian Tube': 13.311333333333334, 'Heart': 1.8932833914053424, 'Kidney': 3.5379516853932587, 'Liver': 0.5239336283185841, 'Lung': 5.0846453287197235, 'Muscle': 4.888150062266501, 'Nerve': 25.21318578352181, 'Ovary': 16.15117777777778, 'Pancreas': 0.8610923780487806, 'Pituitary': 6.484777385159011, 'Prostate': 8.462518367346938, 'Salivary Gland': 4.007416049382717, 'Skin': 4.218661746821448, 'Small Intestine': 9.950946524064172, 'Spleen': 12.007443983402489, 'Stomach': 3.614492479108635, 'Testis': 2.3471296398891965, 'Thyroid': 21.916324655436448, 'Uterus': 20.057894366197186, 'Vagina': 11.536673076923076}
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[34.47, 35.51, 38.9, 44.66, 44.75, 55.33, 58.5, 73.72, 88.52, 91.05, 94.35, 94.95, 94.56, 96.72, 97.7, 96.23, 96.01, 97.87, 97.68, 96.55, 97.25, 95.68, 96.16, 95.56, 93.51, 91.67, 93.19, 91.95, 90.5, 90.58, 83.18, 70.52, 60.28, 46.99, 49.95, 37.31, 35.2, 37.7, 38.46, 40.03, 42.39, 42.36, 40.08, 46.38, 48.97, 49.88, 46.22, 55.23, 51.28, 47.41, 42.03, 38.86, 39.93, 38.86, 45.38, 46.03, 39.55, 45.52, 47.68, 37.31, 44.01, 47.62, 44.99, 45.25, 47.97, 50.69, 46.94, 44.76, 47.95, 50.79, 44.83, 44.14, 46.69, 53.32, 51.5, 47.09, 54.05, 50.66, 44.58, 44.51, 42.95, 49.44, 52.96, 58.89, 61.62, 71.44, 76.96, 84.29, 90.71, 92.18, 93.64, 94.41, 95.4, 96.3, 95.7, 95.05, 95.96, 95.87, 94.07, 92.25, 92.55, 92.22, 89.21, 85.43, 85.47, 87.1, 80.8, 73.45, 79.7, 77.74, 71.62, 72.0, 76.81, 74.08, 69.32, 73.51, 74.89, 71.17, 72.56, 73.09, 77.83, 80.58, 80.12, 84.25, 86.71, 89.78, 91.75, 90.41, 87.25, 91.07, 91.64, 87.1, 86.62, 90.43, 90.32, 85.6, 86.48, 90.83, 90.67, 87.05, 90.32, 92.64, 90.81, 93.39, 89.62, 91.64, 94.44, 93.18, 90.02, 94.22, 96.25, 92.47, 91.34, 94.66, 94.49, 90.57, 92.03, 94.64, 92.73, 89.6, 91.98, 92.94, 89.55, 88.79, 90.06, 88.96, 90.0, 90.88, 92.27, 95.66, 95.21, 95.55, 95.89, 97.49, 97.08, 97.61, 98.27, 97.89, 97.33, 97.29, 96.95, 95.88, 95.44, 95.14, 96.24, 94.61, 94.57, 95.78, 95.7, 94.68, 95.0, 94.37, 93.2, 94.54, 95.31, 92.85, 92.69, 93.57, 93.42, 91.42, 88.31, 86.23, 78.99, 68.45, 60.11, 52.83, 55.84, 53.74, 55.42, 57.46, 53.68, 54.29, 58.17, 61.21, 62.37, 62.64, 60.57, 63.05, 66.67, 61.77, 61.66, 67.79, 64.54, 59.67, 60.97, 58.43, 51.77, 49.18, 44.76, 48.9, 49.29, 43.48, 38.12, 41.67, 40.85, 51.25, 39.64, 42.3, 36.88]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
73.601506
0.459289
2,596
O60260
P11142
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
HSPA8
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
Homo sapiens
Cytoplasm, Melanosome, Nucleus, nucleolus, Cell membrane, Lysosome membrane
Low tissue specificity
{'Ciliated cells': '517.6', 'Basal respiratory cells': '293.9', 'Club cells': '366.5', 'Ionocytes': '245.9', 'Mucus glandular cells': '420.2', 'Serous glandular cells': '293.3', 'Gastric mucus-secreting cells': '347.2', 'Proximal enterocytes': '834.0', 'Paneth cells': '488.4', 'Distal enterocytes': '588.6', 'Intestinal goblet cells': '404.8', 'Exocrine glandular cells': '-0.587', 'Basal prostatic cells': '398.2', 'Prostatic glandular cells': '402.3', 'Breast glandular cells': '-0.348', 'Breast myoepithelial cells': '-0.470', 'Glandular and luminal cells': '410.9', 'Secretory cells': '524.3', 'Basal keratinocytes': '312.4', 'Suprabasal keratinocytes': '477.2', 'Basal squamous epithelial cells': '500.8', 'Squamous epithelial cells': '568.0', 'Alveolar cells type 1': '0.019', 'Alveolar cells type 2': '-0.263', 'Salivary duct cells': '345.6', 'Ductal cells': '0.307', 'Hepatocytes': '0.536', 'Cholangiocytes': '274.7', 'Proximal tubular cells': '0.282', 'Distal tubular cells': '411.8', 'Collecting duct cells': '159.5', 'Mesothelial cells': '-0.076', 'Sertoli cells': '0.467', 'Granulosa cells': '729.7', 'Enteroendocrine cells': '498.1', 'Pancreatic endocrine cells': '504.3', 'Leydig cells': '0.483', 'Excitatory neurons': '32.3', 'Inhibitory neurons': '43.6', 'Cone photoreceptor cells': '321.1', 'Rod photoreceptor cells': '207.0', 'Bipolar cells': '193.7', 'Horizontal cells': '149.8', 'Astrocytes': '68.7', 'Oligodendrocyte precursor cells': '26.4', 'Oligodendrocytes': '46.8', 'Microglial cells': '34.0', 'Muller glia cells': '282.0', 'Schwann cells': '0.063', 'Spermatogonia': '0.740', 'Spermatocytes': '0.515', 'Early spermatids': '-0.295', 'Late spermatids': '-0.400', 'Oocytes': '396.3', 'Cytotrophoblasts': '985.0', 'Syncytiotrophoblasts': '1533.6', 'Extravillous trophoblasts': '1032.5', 'Endothelial cells': '523.1', 'Lymphatic endothelial cells': '581.6', 'Cardiomyocytes': '0.615', 'Skeletal myocytes': '0.010', 'Smooth muscle cells': '436.6', 'Adipocytes': '684.4', 'Melanocytes': '0.016', 'Fibroblasts': '514.9', 'Peritubular cells': '0.299', 'Endometrial stromal cells': '382.3', 'Ovarian stromal cells': '389.3', 'Undifferentiated cells': '689.6', 'T-cells': '1033.6', 'B-cells': '635.7', 'Plasma cells': '721.3', 'Nk-cells': '596.5', 'Granulocytes': '710.5', 'Monocytes': '558.5', 'Macrophages': '616.7', 'Hofbauer cells': '727.5', 'Kupffer cells': '343.7', 'Dendritic cells': '295.8', 'Langerhans cells': '-0.021', 'Erythroid cells': '-0.115', 'Adipocytes (Subcutaneous)': '0.228', 'Adipocytes (Visceral)': '0.165', 'Breast glandular cells (progenitors)': '-0.290', 'Adipocytes (Breast)': '0.528', 'Colon enterocytes': '-0.046', 'Colon enteroendocrine cells': '0.122', 'Enteric glia cells': '-0.244', 'Mitotic cells (Colon)': '0.000', 'Mitotic cells (Heart)': '0.425', 'Podocytes': '0.016', 'Ascending Loop of Henle cells': '0.217', 'Intercalated cells': '0.123', 'Cholangiocyte': '0.311', 'NK-cells (Liver)': '-0.234', 'Respiratory ciliated cells': '-0.011', 'Mitotic cells (Lung)': '0.046', 'NK-cells (Lung)': '0.184', 'B-cells (Lung)': '0.060', 'Alpha cells': '0.167', 'Beta cells': '0.101', 'Prostate glandular cells': '0.089', 'Prostate basal glandular cells': '-0.001', 'Urothelial cells': '-0.033', 'Keratinocyte (other)': '-0.349', 'Keratinocyte (granular)': '-0.007', 'Hair cortex cells': '0.290', 'Inner root sheath cells': '0.325', 'Outer root sheath cells': '0.212', 'Sebaceous gland cells': '0.326', 'Eccrine sweat gland cells': '0.231', 'Adipocytes (Skin)': '0.352', 'Mitotic cells (Skin)': '0.034', 'Parietal cells': '-0.275', 'Chief cells': '-0.016', 'Gastric mucous cells': '-0.184', 'Gastric enteroendocrine cells': '-0.094', 'Mitotic cells (Stomach)': '0.054', 'Parafollicular cells': '0.053', 'Thyroid glandular cells': '0.216', 'Mitotic cells (Thyroid)': '0.134', 'Adrenal cortex cells': '0.433', 'Adrenal medulla cells': '0.046', 'Mitotic cells (Adrenal gland)': '0.116', 'Minor salivary glandular cells': '0.425', 'Minor salivary gland ductal cells': '-0.106', 'Minor salivary gland basal cells': '0.185', 'Mitotic cells (Minor salivary gland)': '0.329', 'Adipocytes (Minor salivary gland)': '0.090', 'Somatotropes': '-0.120', 'Lactotropes': '-0.036', 'Gonadotropes': '0.084', 'Corticotropes': '-0.033', 'Thyrotropes': '0.147', 'Undifferentiated cells (Pituitary gland)': '0.352', 'Mitotic cells (Spleen)': '0.129', 'Platelets': '-0.051', 'Erythrocytes': '0.010', 'Hematopoietic stem cells': '-0.057', 'B-cells (Spleen)': '0.143', 'NK-cells (Spleen)': '0.112', 'Amygdala excitatory': '30.8', 'Cerebellar inhibitory': '159.8', 'Cge interneuron': '98.9', 'Deep-layer corticothalamic and 6b': '48.5', 'Deep-layer intratelencephalic': '41.8', 'Deep-layer near-projecting': '59.5', 'Eccentric medium spiny neuron': '35.4', 'Hippocampal ca1-3': '27.8', 'Hippocampal ca4': '74.3', 'Hippocampal dentate gyrus': '63.2', 'Lamp5-lhx6 and chandelier': '92.4', 'Lower rhombic lip': '93.3', 'Mammillary body': '71.6', 'Medium spiny neuron': '28.9', 'Mge interneuron': '58.1', 'Midbrain-derived inhibitory': '75.7', 'Miscellaneous': '56.6', 'Splatter': '99.2', 'Thalamic excitatory': '81.3', 'Upper rhombic lip': '113.7', 'Upper-layer intratelencephalic': '40.7', 'Astrocyte': '78.1', 'Bergmann glia': '123.0', 'Central nervous system macrophage': '69.0', 'Choroid plexus epithelial cell': '84.7', 'Committed oligodendrocyte precursor': '69.1', 'Ependymal cell': '95.9', 'Oligodendrocyte': '74.3', 'Oligodendrocyte precursor cell': '58.4', 'Endothelial cell': '169.9', 'Pericyte': '119.7', 'Vascular associated smooth muscle cell': '111.6', 'Fibroblast': '57.7', 'Leukocyte': '187.7', 'Basophil': '789.4', 'Eosinophil': '589.0', 'Neutrophil': '361.7', 'Classical monocyte': '260.9', 'Non-classical monocyte': '515.3', 'Intermediate monocyte': '2318.2', 'T-reg': '2206.7', 'GdT-cell': '1248.0', 'MAIT T-cell': '2265.6', 'Memory CD4 T-cell': '1445.5', 'Naive CD4 T-cell': '854.7', 'Memory CD8 T-cell': '1366.0', 'Naive CD8 T-cell': '755.9', 'Memory B-cell': '1012.5', 'Naive B-cell': '175.7', 'Plasmacytoid DC': '1793.3', 'Myeloid DC': '1679.1', 'NK-cell': '555.6', 'Total PBMC': '1537.0', 'Vd2 gdTCR': '1927.2', 'Memory CD4 T-cell Th1\\/Th17': '840.9', 'Memory CD4 T-cell Th17': '898.9', 'Memory CD4 T-cell Th2': '835.0', 'Non-Vd2 gdTCR': '2109.6', 'Memory CD4 T-cell Th1': '722.2', 'Memory CD4 T-cell TFH': '759.7', 'Terminal effector memory CD4 T-cell': '2214.3', 'Central memory CD8 T-cell': '2025.0', 'Effector memory CD8 T-cell': '2336.3', 'Terminal effector memory CD8 T-cell': '2065.4', 'Non-switched memory B-cell': '1245.8', 'Plasmablast': '3227.7', 'Switched memory B-cell': '1967.9', 'Exhausted memory B-cell': '1633.0', 'Progenitor cell': '1086.4', 'Memory T-reg': '868.7', 'Naive CD4 T-cell activated': '2278.9', 'Naive CD8 T-cell activated': '2596.9', 'Naive T-reg': '766.8'}
3AGY, 3AGZ, 3ESK, 3FZF, 3FZH, 3FZK, 3FZL, 3FZM, 3LDQ, 3M3Z, 4H5N, 4H5R, 4H5T, 4H5V, 4H5W, 4HWI, 4KBQ, 5AQF, 5AQG, 5AQH, 5AQI, 5AQJ, 5AQK, 5AQL, 5AQM, 5AQN, 5AQO, 5AQP, 5AQQ, 5AQR, 5AQS, 5AQT, 5AQU, 5AQV, 6B1I, 6B1M, 6B1N, 6ZYJ
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
88.46517
0.319118
1,068
O60260
P14618
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PKM
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
Homo sapiens
Cytoplasm, Nucleus, Cytoplasm
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '294.8', 'Basal respiratory cells': '1894.9', 'Club cells': '694.1', 'Ionocytes': '775.7', 'Mucus glandular cells': '263.7', 'Serous glandular cells': '272.9', 'Gastric mucus-secreting cells': '134.4', 'Proximal enterocytes': '415.3', 'Paneth cells': '251.8', 'Distal enterocytes': '409.5', 'Intestinal goblet cells': '117.9', 'Exocrine glandular cells': '-0.658', 'Basal prostatic cells': '281.8', 'Prostatic glandular cells': '216.0', 'Breast glandular cells': '0.472', 'Breast myoepithelial cells': '0.419', 'Glandular and luminal cells': '196.7', 'Secretory cells': '338.6', 'Basal keratinocytes': '609.0', 'Suprabasal keratinocytes': '587.3', 'Basal squamous epithelial cells': '321.8', 'Squamous epithelial cells': '328.0', 'Alveolar cells type 1': '-0.196', 'Alveolar cells type 2': '0.275', 'Salivary duct cells': '468.6', 'Ductal cells': '0.725', 'Hepatocytes': '0.338', 'Cholangiocytes': '99.2', 'Proximal tubular cells': '0.065', 'Distal tubular cells': '528.6', 'Collecting duct cells': '832.4', 'Mesothelial cells': '0.148', 'Sertoli cells': '0.103', 'Granulosa cells': '123.9', 'Enteroendocrine cells': '364.7', 'Pancreatic endocrine cells': '1370.3', 'Leydig cells': '0.049', 'Excitatory neurons': '87.2', 'Inhibitory neurons': '93.6', 'Cone photoreceptor cells': '1779.0', 'Rod photoreceptor cells': '498.6', 'Bipolar cells': '476.7', 'Horizontal cells': '560.2', 'Astrocytes': '102.2', 'Oligodendrocyte precursor cells': '50.0', 'Oligodendrocytes': '31.1', 'Microglial cells': '36.7', 'Muller glia cells': '648.5', 'Schwann cells': '0.030', 'Spermatogonia': '0.211', 'Spermatocytes': '0.054', 'Early spermatids': '0.030', 'Late spermatids': '0.326', 'Oocytes': '66.9', 'Cytotrophoblasts': '598.7', 'Syncytiotrophoblasts': '512.0', 'Extravillous trophoblasts': '1559.9', 'Endothelial cells': '180.0', 'Lymphatic endothelial cells': '144.3', 'Cardiomyocytes': '0.760', 'Skeletal myocytes': '0.640', 'Smooth muscle cells': '197.1', 'Adipocytes': '93.4', 'Melanocytes': '0.257', 'Fibroblasts': '309.8', 'Peritubular cells': '-0.023', 'Endometrial stromal cells': '76.9', 'Ovarian stromal cells': '144.5', 'Undifferentiated cells': '354.8', 'T-cells': '180.8', 'B-cells': '171.7', 'Plasma cells': '253.7', 'Nk-cells': '66.8', 'Granulocytes': '195.9', 'Monocytes': '209.0', 'Macrophages': '470.7', 'Hofbauer cells': '744.6', 'Kupffer cells': '275.9', 'Dendritic cells': '79.0', 'Langerhans cells': '0.205', 'Erythroid cells': '0.021', 'Adipocytes (Subcutaneous)': '-0.446', 'Adipocytes (Visceral)': '-0.179', 'Breast glandular cells (progenitors)': '0.200', 'Adipocytes (Breast)': '-0.445', 'Colon enterocytes': '-0.088', 'Colon enteroendocrine cells': '0.167', 'Enteric glia cells': '0.073', 'Mitotic cells (Colon)': '0.149', 'Mitotic cells (Heart)': '0.511', 'Podocytes': '-0.231', 'Ascending Loop of Henle cells': '0.448', 'Intercalated cells': '-0.158', 'Cholangiocyte': '0.515', 'NK-cells (Liver)': '-0.317', 'Respiratory ciliated cells': '-0.079', 'Mitotic cells (Lung)': '0.395', 'NK-cells (Lung)': '-0.244', 'B-cells (Lung)': '-0.174', 'Alpha cells': '0.462', 'Beta cells': '0.269', 'Prostate glandular cells': '-0.122', 'Prostate basal glandular cells': '0.275', 'Urothelial cells': '0.266', 'Keratinocyte (other)': '0.290', 'Keratinocyte (granular)': '-0.201', 'Hair cortex cells': '0.098', 'Inner root sheath cells': '0.078', 'Outer root sheath cells': '0.181', 'Sebaceous gland cells': '0.020', 'Eccrine sweat gland cells': '-0.052', 'Adipocytes (Skin)': '-0.239', 'Mitotic cells (Skin)': '0.336', 'Parietal cells': '-0.509', 'Chief cells': '-0.441', 'Gastric mucous cells': '-0.141', 'Gastric enteroendocrine cells': '-0.339', 'Mitotic cells (Stomach)': '0.351', 'Parafollicular cells': '0.115', 'Thyroid glandular cells': '0.425', 'Mitotic cells (Thyroid)': '0.122', 'Adrenal cortex cells': '0.563', 'Adrenal medulla cells': '0.004', 'Mitotic cells (Adrenal gland)': '0.416', 'Minor salivary glandular cells': '0.318', 'Minor salivary gland ductal cells': '-0.130', 'Minor salivary gland basal cells': '0.542', 'Mitotic cells (Minor salivary gland)': '0.650', 'Adipocytes (Minor salivary gland)': '0.259', 'Somatotropes': '-0.451', 'Lactotropes': '-0.259', 'Gonadotropes': '-0.041', 'Corticotropes': '-0.015', 'Thyrotropes': '0.159', 'Undifferentiated cells (Pituitary gland)': '0.505', 'Mitotic cells (Spleen)': '0.163', 'Platelets': '0.129', 'Erythrocytes': '-0.006', 'Hematopoietic stem cells': '0.185', 'B-cells (Spleen)': '0.077', 'NK-cells (Spleen)': '-0.129', 'Amygdala excitatory': '105.7', 'Cerebellar inhibitory': '369.3', 'Cge interneuron': '150.8', 'Deep-layer corticothalamic and 6b': '104.4', 'Deep-layer intratelencephalic': '113.0', 'Deep-layer near-projecting': '129.4', 'Eccentric medium spiny neuron': '150.3', 'Hippocampal ca1-3': '117.1', 'Hippocampal ca4': '149.8', 'Hippocampal dentate gyrus': '104.1', 'Lamp5-lhx6 and chandelier': '166.8', 'Lower rhombic lip': '208.9', 'Mammillary body': '175.2', 'Medium spiny neuron': '131.9', 'Mge interneuron': '148.1', 'Midbrain-derived inhibitory': '187.5', 'Miscellaneous': '138.5', 'Splatter': '176.2', 'Thalamic excitatory': '224.5', 'Upper rhombic lip': '178.9', 'Upper-layer intratelencephalic': '121.1', 'Astrocyte': '170.8', 'Bergmann glia': '104.2', 'Central nervous system macrophage': '79.2', 'Choroid plexus epithelial cell': '310.7', 'Committed oligodendrocyte precursor': '99.8', 'Ependymal cell': '299.2', 'Oligodendrocyte': '40.7', 'Oligodendrocyte precursor cell': '99.2', 'Endothelial cell': '120.4', 'Pericyte': '130.7', 'Vascular associated smooth muscle cell': '123.3', 'Fibroblast': '68.7', 'Leukocyte': '109.7', 'Basophil': '225.2', 'Eosinophil': '138.8', 'Neutrophil': '148.5', 'Classical monocyte': '358.7', 'Non-classical monocyte': '192.5', 'Intermediate monocyte': '672.7', 'T-reg': '391.1', 'GdT-cell': '193.0', 'MAIT T-cell': '304.4', 'Memory CD4 T-cell': '254.7', 'Naive CD4 T-cell': '159.4', 'Memory CD8 T-cell': '190.5', 'Naive CD8 T-cell': '124.9', 'Memory B-cell': '205.4', 'Naive B-cell': '53.6', 'Plasmacytoid DC': '343.7', 'Myeloid DC': '986.2', 'NK-cell': '90.2', 'Total PBMC': '672.7', 'Vd2 gdTCR': '307.7', 'Memory CD4 T-cell Th1\\/Th17': '132.7', 'Memory CD4 T-cell Th17': '231.9', 'Memory CD4 T-cell Th2': '235.3', 'Non-Vd2 gdTCR': '355.0', 'Memory CD4 T-cell Th1': '174.5', 'Memory CD4 T-cell TFH': '256.6', 'Terminal effector memory CD4 T-cell': '303.4', 'Central memory CD8 T-cell': '380.0', 'Effector memory CD8 T-cell': '352.1', 'Terminal effector memory CD8 T-cell': '299.1', 'Non-switched memory B-cell': '407.3', 'Plasmablast': '645.3', 'Switched memory B-cell': '421.9', 'Exhausted memory B-cell': '374.2', 'Progenitor cell': '186.5', 'Memory T-reg': '265.9', 'Naive CD4 T-cell activated': '1125.1', 'Naive CD8 T-cell activated': '1121.5', 'Naive T-reg': '159.6'}
1T5A, 1ZJH, 3BJF, 3BJT, 3G2G, 3GQY, 3GR4, 3H6O, 3ME3, 3SRD, 3SRF, 3SRH, 3U2Z, 4B2D, 4FXF, 4FXJ, 4G1N, 4JPG, 4QG6, 4QG8, 4QG9, 4QGC, 4RPP, 4WJ8, 4YJ5, 5X0I, 5X1V, 5X1W, 6B6U, 6GG3, 6GG4, 6GG5, 6GG6, 6JFB, 6NU1, 6NU5, 6NUB, 6TTF, 6TTH, 6TTI, 6TTQ, 6V74, 6V75, 6V76, 6WP3, 6WP4, 6WP5, 6WP6, 7L21, 8G2E, 8HGF, 8HMQ, 8HMR, 8HMS, 8HMU
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
96.680226
0.280038
1,474
O60260
P14635
26387737
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
CCNB1
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAKV
Homo sapiens
Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Tissue enhanced (bone marrow, lymphoid tissue)
{'Ciliated cells': '12.6', 'Basal respiratory cells': '33.5', 'Club cells': '9.1', 'Ionocytes': '13.3', 'Mucus glandular cells': '5.9', 'Serous glandular cells': '7.9', 'Gastric mucus-secreting cells': '22.4', 'Proximal enterocytes': '1.1', 'Paneth cells': '6.0', 'Distal enterocytes': '2.9', 'Intestinal goblet cells': '11.9', 'Exocrine glandular cells': '-0.453', 'Basal prostatic cells': '2.5', 'Prostatic glandular cells': '2.7', 'Breast glandular cells': '0.501', 'Breast myoepithelial cells': '0.525', 'Glandular and luminal cells': '14.5', 'Secretory cells': '8.1', 'Basal keratinocytes': '32.2', 'Suprabasal keratinocytes': '15.5', 'Basal squamous epithelial cells': '14.2', 'Squamous epithelial cells': '35.8', 'Alveolar cells type 1': '-0.244', 'Alveolar cells type 2': '0.232', 'Salivary duct cells': '7.2', 'Ductal cells': '0.446', 'Hepatocytes': '0.439', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.257', 'Distal tubular cells': '0.0', 'Collecting duct cells': '5.8', 'Mesothelial cells': '0.215', 'Sertoli cells': '-0.066', 'Granulosa cells': '20.0', 'Enteroendocrine cells': '6.1', 'Pancreatic endocrine cells': '23.8', 'Leydig cells': '-0.102', 'Excitatory neurons': '2.6', 'Inhibitory neurons': '2.0', 'Cone photoreceptor cells': '3.4', 'Rod photoreceptor cells': '1.8', 'Bipolar cells': '2.5', 'Horizontal cells': '3.8', 'Astrocytes': '1.9', 'Oligodendrocyte precursor cells': '0.5', 'Oligodendrocytes': '1.0', 'Microglial cells': '0.9', 'Muller glia cells': '3.1', 'Schwann cells': '0.064', 'Spermatogonia': '0.428', 'Spermatocytes': '0.569', 'Early spermatids': '0.479', 'Late spermatids': '0.165', 'Oocytes': '341.9', 'Cytotrophoblasts': '131.3', 'Syncytiotrophoblasts': '32.8', 'Extravillous trophoblasts': '819.0', 'Endothelial cells': '5.4', 'Lymphatic endothelial cells': '2.6', 'Cardiomyocytes': '0.596', 'Skeletal myocytes': '-0.059', 'Smooth muscle cells': '6.7', 'Adipocytes': '3.2', 'Melanocytes': '0.445', 'Fibroblasts': '13.2', 'Peritubular cells': '-0.070', 'Endometrial stromal cells': '6.4', 'Ovarian stromal cells': '6.9', 'Undifferentiated cells': '66.1', 'T-cells': '6.8', 'B-cells': '4.6', 'Plasma cells': '33.5', 'Nk-cells': '3.2', 'Granulocytes': '3.0', 'Monocytes': '2.4', 'Macrophages': '9.5', 'Hofbauer cells': '43.5', 'Kupffer cells': '8.6', 'Dendritic cells': '6.8', 'Langerhans cells': '0.123', 'Erythroid cells': '0.077', 'Adipocytes (Subcutaneous)': '-0.045', 'Adipocytes (Visceral)': '-0.127', 'Breast glandular cells (progenitors)': '0.436', 'Adipocytes (Breast)': '-0.447', 'Colon enterocytes': '0.352', 'Colon enteroendocrine cells': '0.018', 'Enteric glia cells': '-0.227', 'Mitotic cells (Colon)': '0.479', 'Mitotic cells (Heart)': '0.610', 'Podocytes': '-0.153', 'Ascending Loop of Henle cells': '0.476', 'Intercalated cells': '-0.063', 'Cholangiocyte': '0.407', 'NK-cells (Liver)': '-0.227', 'Respiratory ciliated cells': '0.083', 'Mitotic cells (Lung)': '0.752', 'NK-cells (Lung)': '-0.249', 'B-cells (Lung)': '-0.118', 'Alpha cells': '0.257', 'Beta cells': '0.125', 'Prostate glandular cells': '-0.008', 'Prostate basal glandular cells': '0.333', 'Urothelial cells': '0.209', 'Keratinocyte (other)': '0.170', 'Keratinocyte (granular)': '-0.174', 'Hair cortex cells': '0.142', 'Inner root sheath cells': '0.280', 'Outer root sheath cells': '0.277', 'Sebaceous gland cells': '0.150', 'Eccrine sweat gland cells': '0.033', 'Adipocytes (Skin)': '-0.047', 'Mitotic cells (Skin)': '0.894', 'Parietal cells': '-0.004', 'Chief cells': '-0.023', 'Gastric mucous cells': '0.410', 'Gastric enteroendocrine cells': '0.101', 'Mitotic cells (Stomach)': '0.864', 'Parafollicular cells': '0.083', 'Thyroid glandular cells': '0.476', 'Mitotic cells (Thyroid)': '0.162', 'Adrenal cortex cells': '0.519', 'Adrenal medulla cells': '0.068', 'Mitotic cells (Adrenal gland)': '0.807', 'Minor salivary glandular cells': '0.170', 'Minor salivary gland ductal cells': '-0.281', 'Minor salivary gland basal cells': '0.715', 'Mitotic cells (Minor salivary gland)': '0.890', 'Adipocytes (Minor salivary gland)': '0.192', 'Somatotropes': '-0.063', 'Lactotropes': '0.011', 'Gonadotropes': '0.161', 'Corticotropes': '-0.107', 'Thyrotropes': '0.219', 'Undifferentiated cells (Pituitary gland)': '0.378', 'Mitotic cells (Spleen)': '0.900', 'Platelets': '0.199', 'Erythrocytes': '0.259', 'Hematopoietic stem cells': '0.364', 'B-cells (Spleen)': '-0.072', 'NK-cells (Spleen)': '-0.244', 'Amygdala excitatory': '3.4', 'Cerebellar inhibitory': '6.0', 'Cge interneuron': '3.4', 'Deep-layer corticothalamic and 6b': '4.5', 'Deep-layer intratelencephalic': '3.7', 'Deep-layer near-projecting': '5.3', 'Eccentric medium spiny neuron': '3.9', 'Hippocampal ca1-3': '4.4', 'Hippocampal ca4': '4.4', 'Hippocampal dentate gyrus': '3.9', 'Lamp5-lhx6 and chandelier': '3.9', 'Lower rhombic lip': '10.4', 'Mammillary body': '3.8', 'Medium spiny neuron': '4.0', 'Mge interneuron': '3.6', 'Midbrain-derived inhibitory': '4.1', 'Miscellaneous': '4.8', 'Splatter': '5.9', 'Thalamic excitatory': '7.5', 'Upper rhombic lip': '6.1', 'Upper-layer intratelencephalic': '3.3', 'Astrocyte': '1.5', 'Bergmann glia': '2.3', 'Central nervous system macrophage': '1.3', 'Choroid plexus epithelial cell': '1.5', 'Committed oligodendrocyte precursor': '1.8', 'Ependymal cell': '4.5', 'Oligodendrocyte': '1.6', 'Oligodendrocyte precursor cell': '2.1', 'Endothelial cell': '1.7', 'Pericyte': '1.7', 'Vascular associated smooth muscle cell': '1.7', 'Fibroblast': '2.6', 'Leukocyte': '0.9', 'Basophil': '4.3', 'Eosinophil': '1.5', 'Neutrophil': '1.7', 'Classical monocyte': '0.9', 'Non-classical monocyte': '1.7', 'Intermediate monocyte': '9.7', 'T-reg': '10.6', 'GdT-cell': '3.2', 'MAIT T-cell': '8.4', 'Memory CD4 T-cell': '8.4', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '7.4', 'Naive CD8 T-cell': '2.5', 'Memory B-cell': '15.4', 'Naive B-cell': '3.7', 'Plasmacytoid DC': '13.2', 'Myeloid DC': '14.1', 'NK-cell': '3.4', 'Total PBMC': '14.1', 'Vd2 gdTCR': '8.1', 'Memory CD4 T-cell Th1\\/Th17': '2.4', 'Memory CD4 T-cell Th17': '2.6', 'Memory CD4 T-cell Th2': '2.6', 'Non-Vd2 gdTCR': '6.0', 'Memory CD4 T-cell Th1': '2.9', 'Memory CD4 T-cell TFH': '2.2', 'Terminal effector memory CD4 T-cell': '8.3', 'Central memory CD8 T-cell': '8.2', 'Effector memory CD8 T-cell': '18.3', 'Terminal effector memory CD8 T-cell': '6.0', 'Non-switched memory B-cell': '11.3', 'Plasmablast': '98.3', 'Switched memory B-cell': '12.8', 'Exhausted memory B-cell': '17.0', 'Progenitor cell': '21.5', 'Memory T-reg': '4.6', 'Naive CD4 T-cell activated': '8.5', 'Naive CD8 T-cell activated': '14.6', 'Naive T-reg': '2.6'}
2B9R, 2JGZ, 4Y72, 4YC3, 5HQ0, 5LQF, 6GU2, 6GU3, 6GU4, 7NJ0, 8TAR, 8TAU
{'Adipose Tissue': 3.471605897009967, 'Adrenal Gland': 4.868292635658914, 'Bladder': 4.231428571428571, 'Blood': 27.753815274488694, 'Blood Vessel': 2.457598426966292, 'Brain': 4.443561468584406, 'Breast': 4.344958823529412, 'Cervix Uteri': 6.517894736842106, 'Colon': 7.593514762516046, 'Esophagus': 15.178753425605535, 'Fallopian Tube': 5.192666666666667, 'Heart': 1.2794448780487804, 'Kidney': 3.2647191011235956, 'Liver': 1.9414774336283185, 'Lung': 5.595865743944637, 'Muscle': 1.3092511830635118, 'Nerve': 3.738533117932149, 'Ovary': 6.13905, 'Pancreas': 1.6150481707317077, 'Pituitary': 3.8263169611307424, 'Prostate': 3.7488726530612246, 'Salivary Gland': 6.814722222222222, 'Skin': 41.45389275843007, 'Small Intestine': 12.582085561497326, 'Spleen': 12.003697095435683, 'Stomach': 8.000085793871866, 'Testis': 41.52831024930748, 'Thyroid': 8.046928024502298, 'Uterus': 4.830894366197183, 'Vagina': 13.33153846153846}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
76.75224
0.481755
1,831
O60260
P15311
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
EZR
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
Homo sapiens
Apical cell membrane, Cell projection, Cell projection, microvillus membrane, Cell projection, ruffle membrane, Cytoplasm, cell cortex, Cytoplasm, cytoskeleton, Cell projection, microvillus
Low tissue specificity
{'Ciliated cells': '657.2', 'Basal respiratory cells': '188.3', 'Club cells': '456.7', 'Ionocytes': '339.1', 'Mucus glandular cells': '511.3', 'Serous glandular cells': '222.3', 'Gastric mucus-secreting cells': '487.0', 'Proximal enterocytes': '655.0', 'Paneth cells': '389.6', 'Distal enterocytes': '721.8', 'Intestinal goblet cells': '373.4', 'Exocrine glandular cells': '-0.658', 'Basal prostatic cells': '247.2', 'Prostatic glandular cells': '130.9', 'Breast glandular cells': '0.703', 'Breast myoepithelial cells': '0.615', 'Glandular and luminal cells': '876.3', 'Secretory cells': '423.0', 'Basal keratinocytes': '565.6', 'Suprabasal keratinocytes': '793.7', 'Basal squamous epithelial cells': '287.6', 'Squamous epithelial cells': '442.5', 'Alveolar cells type 1': '0.469', 'Alveolar cells type 2': '0.430', 'Salivary duct cells': '349.5', 'Ductal cells': '0.667', 'Hepatocytes': '0.213', 'Cholangiocytes': '158.4', 'Proximal tubular cells': '0.425', 'Distal tubular cells': '70.7', 'Collecting duct cells': '177.0', 'Mesothelial cells': '0.865', 'Sertoli cells': '0.742', 'Granulosa cells': '116.5', 'Enteroendocrine cells': '231.1', 'Pancreatic endocrine cells': '139.2', 'Leydig cells': '0.694', 'Excitatory neurons': '0.4', 'Inhibitory neurons': '0.5', 'Cone photoreceptor cells': '1.7', 'Rod photoreceptor cells': '3.3', 'Bipolar cells': '10.1', 'Horizontal cells': '0.6', 'Astrocytes': '105.6', 'Oligodendrocyte precursor cells': '1.9', 'Oligodendrocytes': '0.7', 'Microglial cells': '11.6', 'Muller glia cells': '37.6', 'Schwann cells': '-0.037', 'Spermatogonia': '0.638', 'Spermatocytes': '0.226', 'Early spermatids': '-0.582', 'Late spermatids': '-0.727', 'Oocytes': '475.7', 'Cytotrophoblasts': '398.2', 'Syncytiotrophoblasts': '1528.6', 'Extravillous trophoblasts': '627.1', 'Endothelial cells': '64.0', 'Lymphatic endothelial cells': '39.6', 'Cardiomyocytes': '0.701', 'Skeletal myocytes': '-0.199', 'Smooth muscle cells': '115.9', 'Adipocytes': '46.0', 'Melanocytes': '0.213', 'Fibroblasts': '90.7', 'Peritubular cells': '0.508', 'Endometrial stromal cells': '76.8', 'Ovarian stromal cells': '45.1', 'Undifferentiated cells': '196.1', 'T-cells': '467.7', 'B-cells': '730.1', 'Plasma cells': '597.0', 'Nk-cells': '322.0', 'Granulocytes': '204.0', 'Monocytes': '565.4', 'Macrophages': '320.0', 'Hofbauer cells': '103.2', 'Kupffer cells': '86.2', 'Dendritic cells': '1618.0', 'Langerhans cells': '0.200', 'Erythroid cells': '0.142', 'Adipocytes (Subcutaneous)': '-0.307', 'Adipocytes (Visceral)': '-0.137', 'Breast glandular cells (progenitors)': '0.497', 'Adipocytes (Breast)': '-0.638', 'Colon enterocytes': '0.238', 'Colon enteroendocrine cells': '0.118', 'Enteric glia cells': '-0.170', 'Mitotic cells (Colon)': '0.206', 'Mitotic cells (Heart)': '0.459', 'Podocytes': '0.053', 'Ascending Loop of Henle cells': '0.263', 'Intercalated cells': '0.053', 'Cholangiocyte': '0.403', 'NK-cells (Liver)': '-0.287', 'Respiratory ciliated cells': '0.156', 'Mitotic cells (Lung)': '-0.132', 'NK-cells (Lung)': '-0.074', 'B-cells (Lung)': '-0.108', 'Alpha cells': '0.275', 'Beta cells': '0.115', 'Prostate glandular cells': '-0.054', 'Prostate basal glandular cells': '0.190', 'Urothelial cells': '0.328', 'Keratinocyte (other)': '0.576', 'Keratinocyte (granular)': '0.353', 'Hair cortex cells': '-0.202', 'Inner root sheath cells': '-0.185', 'Outer root sheath cells': '-0.262', 'Sebaceous gland cells': '-0.235', 'Eccrine sweat gland cells': '-0.418', 'Adipocytes (Skin)': '-0.451', 'Mitotic cells (Skin)': '0.004', 'Parietal cells': '0.736', 'Chief cells': '0.494', 'Gastric mucous cells': '0.753', 'Gastric enteroendocrine cells': '0.482', 'Mitotic cells (Stomach)': '0.324', 'Parafollicular cells': '0.088', 'Thyroid glandular cells': '0.574', 'Mitotic cells (Thyroid)': '-0.079', 'Adrenal cortex cells': '0.735', 'Adrenal medulla cells': '0.056', 'Mitotic cells (Adrenal gland)': '0.389', 'Minor salivary glandular cells': '0.262', 'Minor salivary gland ductal cells': '-0.252', 'Minor salivary gland basal cells': '0.750', 'Mitotic cells (Minor salivary gland)': '0.696', 'Adipocytes (Minor salivary gland)': '0.193', 'Somatotropes': '-0.111', 'Lactotropes': '-0.181', 'Gonadotropes': '0.058', 'Corticotropes': '0.271', 'Thyrotropes': '0.117', 'Undifferentiated cells (Pituitary gland)': '0.123', 'Mitotic cells (Spleen)': '-0.005', 'Platelets': '-0.096', 'Erythrocytes': '-0.274', 'Hematopoietic stem cells': '-0.137', 'B-cells (Spleen)': '0.654', 'NK-cells (Spleen)': '0.139', 'Amygdala excitatory': '0.7', 'Cerebellar inhibitory': '2.5', 'Cge interneuron': '0.8', 'Deep-layer corticothalamic and 6b': '0.9', 'Deep-layer intratelencephalic': '0.6', 'Deep-layer near-projecting': '3.2', 'Eccentric medium spiny neuron': '0.9', 'Hippocampal ca1-3': '1.1', 'Hippocampal ca4': '1.9', 'Hippocampal dentate gyrus': '1.4', 'Lamp5-lhx6 and chandelier': '0.5', 'Lower rhombic lip': '3.8', 'Mammillary body': '1.5', 'Medium spiny neuron': '1.8', 'Mge interneuron': '1.2', 'Midbrain-derived inhibitory': '0.6', 'Miscellaneous': '0.7', 'Splatter': '5.1', 'Thalamic excitatory': '0.7', 'Upper rhombic lip': '1.4', 'Upper-layer intratelencephalic': '0.7', 'Astrocyte': '190.9', 'Bergmann glia': '34.1', 'Central nervous system macrophage': '44.6', 'Choroid plexus epithelial cell': '490.9', 'Committed oligodendrocyte precursor': '15.9', 'Ependymal cell': '300.3', 'Oligodendrocyte': '1.4', 'Oligodendrocyte precursor cell': '4.1', 'Endothelial cell': '19.0', 'Pericyte': '52.7', 'Vascular associated smooth muscle cell': '33.7', 'Fibroblast': '68.8', 'Leukocyte': '200.5', 'Basophil': '358.7', 'Eosinophil': '103.8', 'Neutrophil': '91.4', 'Classical monocyte': '212.0', 'Non-classical monocyte': '259.2', 'Intermediate monocyte': '347.5', 'T-reg': '384.3', 'GdT-cell': '196.2', 'MAIT T-cell': '393.1', 'Memory CD4 T-cell': '206.0', 'Naive CD4 T-cell': '175.3', 'Memory CD8 T-cell': '245.0', 'Naive CD8 T-cell': '209.9', 'Memory B-cell': '467.8', 'Naive B-cell': '1063.1', 'Plasmacytoid DC': '266.9', 'Myeloid DC': '363.0', 'NK-cell': '200.6', 'Total PBMC': '333.8', 'Vd2 gdTCR': '374.6', 'Memory CD4 T-cell Th1\\/Th17': '400.7', 'Memory CD4 T-cell Th17': '467.2', 'Memory CD4 T-cell Th2': '455.8', 'Non-Vd2 gdTCR': '392.4', 'Memory CD4 T-cell Th1': '447.1', 'Memory CD4 T-cell TFH': '510.9', 'Terminal effector memory CD4 T-cell': '403.2', 'Central memory CD8 T-cell': '432.7', 'Effector memory CD8 T-cell': '565.3', 'Terminal effector memory CD8 T-cell': '474.9', 'Non-switched memory B-cell': '690.7', 'Plasmablast': '556.7', 'Switched memory B-cell': '911.4', 'Exhausted memory B-cell': '910.8', 'Progenitor cell': '116.2', 'Memory T-reg': '783.3', 'Naive CD4 T-cell activated': '742.7', 'Naive CD8 T-cell activated': '1110.0', 'Naive T-reg': '270.0'}
1NI2, 4RM8, 4RM9, 4RMA, 7T1K, 7T1L
{'Adipose Tissue': 99.82331395348838, 'Adrenal Gland': 268.4604263565891, 'Bladder': 196.64857142857144, 'Blood': 127.9972012917115, 'Blood Vessel': 74.63850187265918, 'Brain': 62.81278879636639, 'Breast': 68.85849673202614, 'Cervix Uteri': 94.13473684210526, 'Colon': 111.23869062901156, 'Esophagus': 247.9766089965398, 'Fallopian Tube': 119.93666666666668, 'Heart': 92.42921486643438, 'Kidney': 136.7208988764045, 'Liver': 42.662544247787615, 'Lung': 327.611401384083, 'Muscle': 40.142439601494395, 'Nerve': 165.340549273021, 'Ovary': 97.42461111111112, 'Pancreas': 59.648201219512195, 'Pituitary': 85.58441696113074, 'Prostate': 140.75542857142858, 'Salivary Gland': 144.43623456790124, 'Skin': 237.53214372581536, 'Small Intestine': 266.6870053475936, 'Spleen': 129.3896265560166, 'Stomach': 233.99518105849583, 'Testis': 123.093324099723, 'Thyroid': 236.8523124042879, 'Uterus': 68.06014084507042, 'Vagina': 185.50108974358977}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
88.084113
0.368396
1,247
O60260
P17980
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PSMC3
MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
Homo sapiens
Cytoplasm, Nucleus
Low tissue specificity
{'Ciliated cells': '78.3', 'Basal respiratory cells': '193.8', 'Club cells': '98.5', 'Ionocytes': '116.0', 'Mucus glandular cells': '87.8', 'Serous glandular cells': '102.6', 'Gastric mucus-secreting cells': '49.5', 'Proximal enterocytes': '126.7', 'Paneth cells': '102.6', 'Distal enterocytes': '137.8', 'Intestinal goblet cells': '91.1', 'Exocrine glandular cells': '-0.786', 'Basal prostatic cells': '73.2', 'Prostatic glandular cells': '49.3', 'Breast glandular cells': '0.027', 'Breast myoepithelial cells': '-0.129', 'Glandular and luminal cells': '74.3', 'Secretory cells': '93.6', 'Basal keratinocytes': '103.2', 'Suprabasal keratinocytes': '116.3', 'Basal squamous epithelial cells': '55.0', 'Squamous epithelial cells': '47.9', 'Alveolar cells type 1': '-0.016', 'Alveolar cells type 2': '-0.055', 'Salivary duct cells': '77.4', 'Ductal cells': '0.607', 'Hepatocytes': '0.455', 'Cholangiocytes': '89.7', 'Proximal tubular cells': '0.200', 'Distal tubular cells': '116.8', 'Collecting duct cells': '64.2', 'Mesothelial cells': '0.225', 'Sertoli cells': '-0.453', 'Granulosa cells': '63.8', 'Enteroendocrine cells': '74.6', 'Pancreatic endocrine cells': '268.3', 'Leydig cells': '-0.470', 'Excitatory neurons': '6.1', 'Inhibitory neurons': '5.1', 'Cone photoreceptor cells': '54.4', 'Rod photoreceptor cells': '27.9', 'Bipolar cells': '43.3', 'Horizontal cells': '26.4', 'Astrocytes': '3.7', 'Oligodendrocyte precursor cells': '2.8', 'Oligodendrocytes': '4.8', 'Microglial cells': '1.8', 'Muller glia cells': '101.2', 'Schwann cells': '0.048', 'Spermatogonia': '-0.246', 'Spermatocytes': '0.082', 'Early spermatids': '0.750', 'Late spermatids': '0.594', 'Oocytes': '44.8', 'Cytotrophoblasts': '272.7', 'Syncytiotrophoblasts': '374.5', 'Extravillous trophoblasts': '271.3', 'Endothelial cells': '92.6', 'Lymphatic endothelial cells': '105.7', 'Cardiomyocytes': '0.669', 'Skeletal myocytes': '-0.284', 'Smooth muscle cells': '114.6', 'Adipocytes': '77.2', 'Melanocytes': '0.340', 'Fibroblasts': '108.2', 'Peritubular cells': '-0.379', 'Endometrial stromal cells': '75.1', 'Ovarian stromal cells': '84.4', 'Undifferentiated cells': '108.8', 'T-cells': '59.0', 'B-cells': '46.0', 'Plasma cells': '123.3', 'Nk-cells': '66.8', 'Granulocytes': '80.8', 'Monocytes': '75.9', 'Macrophages': '65.3', 'Hofbauer cells': '136.8', 'Kupffer cells': '56.7', 'Dendritic cells': '48.3', 'Langerhans cells': '0.216', 'Erythroid cells': '-0.078', 'Adipocytes (Subcutaneous)': '0.071', 'Adipocytes (Visceral)': '-0.005', 'Breast glandular cells (progenitors)': '-0.063', 'Adipocytes (Breast)': '0.154', 'Colon enterocytes': '-0.329', 'Colon enteroendocrine cells': '0.145', 'Enteric glia cells': '0.245', 'Mitotic cells (Colon)': '-0.354', 'Mitotic cells (Heart)': '0.454', 'Podocytes': '-0.019', 'Ascending Loop of Henle cells': '0.398', 'Intercalated cells': '0.040', 'Cholangiocyte': '0.344', 'NK-cells (Liver)': '-0.394', 'Respiratory ciliated cells': '-0.063', 'Mitotic cells (Lung)': '0.044', 'NK-cells (Lung)': '-0.054', 'B-cells (Lung)': '-0.208', 'Alpha cells': '0.352', 'Beta cells': '0.187', 'Prostate glandular cells': '-0.247', 'Prostate basal glandular cells': '-0.016', 'Urothelial cells': '-0.082', 'Keratinocyte (other)': '0.270', 'Keratinocyte (granular)': '0.200', 'Hair cortex cells': '0.203', 'Inner root sheath cells': '0.215', 'Outer root sheath cells': '0.101', 'Sebaceous gland cells': '-0.035', 'Eccrine sweat gland cells': '-0.265', 'Adipocytes (Skin)': '-0.178', 'Mitotic cells (Skin)': '0.287', 'Parietal cells': '-0.736', 'Chief cells': '-0.522', 'Gastric mucous cells': '-0.414', 'Gastric enteroendocrine cells': '-0.465', 'Mitotic cells (Stomach)': '0.095', 'Parafollicular cells': '0.104', 'Thyroid glandular cells': '0.372', 'Mitotic cells (Thyroid)': '-0.105', 'Adrenal cortex cells': '0.409', 'Adrenal medulla cells': '0.052', 'Mitotic cells (Adrenal gland)': '0.287', 'Minor salivary glandular cells': '0.540', 'Minor salivary gland ductal cells': '-0.158', 'Minor salivary gland basal cells': '0.354', 'Mitotic cells (Minor salivary gland)': '0.504', 'Adipocytes (Minor salivary gland)': '0.221', 'Somatotropes': '-0.135', 'Lactotropes': '-0.271', 'Gonadotropes': '-0.119', 'Corticotropes': '-0.206', 'Thyrotropes': '-0.037', 'Undifferentiated cells (Pituitary gland)': '0.365', 'Mitotic cells (Spleen)': '-0.129', 'Platelets': '-0.087', 'Erythrocytes': '-0.064', 'Hematopoietic stem cells': '-0.115', 'B-cells (Spleen)': '0.047', 'NK-cells (Spleen)': '-0.046', 'Amygdala excitatory': '11.1', 'Cerebellar inhibitory': '20.5', 'Cge interneuron': '19.5', 'Deep-layer corticothalamic and 6b': '18.6', 'Deep-layer intratelencephalic': '20.0', 'Deep-layer near-projecting': '20.1', 'Eccentric medium spiny neuron': '13.3', 'Hippocampal ca1-3': '12.6', 'Hippocampal ca4': '32.3', 'Hippocampal dentate gyrus': '20.7', 'Lamp5-lhx6 and chandelier': '20.6', 'Lower rhombic lip': '25.2', 'Mammillary body': '12.2', 'Medium spiny neuron': '19.2', 'Mge interneuron': '17.1', 'Midbrain-derived inhibitory': '15.8', 'Miscellaneous': '19.4', 'Splatter': '19.4', 'Thalamic excitatory': '25.4', 'Upper rhombic lip': '25.0', 'Upper-layer intratelencephalic': '16.1', 'Astrocyte': '10.4', 'Bergmann glia': '17.7', 'Central nervous system macrophage': '11.9', 'Choroid plexus epithelial cell': '19.2', 'Committed oligodendrocyte precursor': '21.2', 'Ependymal cell': '16.4', 'Oligodendrocyte': '19.1', 'Oligodendrocyte precursor cell': '15.3', 'Endothelial cell': '26.9', 'Pericyte': '36.1', 'Vascular associated smooth muscle cell': '31.2', 'Fibroblast': '16.6', 'Leukocyte': '19.0', 'Basophil': '81.2', 'Eosinophil': '122.1', 'Neutrophil': '26.7', 'Classical monocyte': '64.4', 'Non-classical monocyte': '79.9', 'Intermediate monocyte': '197.8', 'T-reg': '148.9', 'GdT-cell': '161.2', 'MAIT T-cell': '177.8', 'Memory CD4 T-cell': '133.3', 'Naive CD4 T-cell': '55.1', 'Memory CD8 T-cell': '147.8', 'Naive CD8 T-cell': '55.4', 'Memory B-cell': '147.4', 'Naive B-cell': '44.4', 'Plasmacytoid DC': '241.9', 'Myeloid DC': '164.2', 'NK-cell': '95.2', 'Total PBMC': '189.7', 'Vd2 gdTCR': '172.2', 'Memory CD4 T-cell Th1\\/Th17': '64.5', 'Memory CD4 T-cell Th17': '76.5', 'Memory CD4 T-cell Th2': '74.8', 'Non-Vd2 gdTCR': '188.6', 'Memory CD4 T-cell Th1': '76.7', 'Memory CD4 T-cell TFH': '84.9', 'Terminal effector memory CD4 T-cell': '140.0', 'Central memory CD8 T-cell': '114.9', 'Effector memory CD8 T-cell': '194.0', 'Terminal effector memory CD8 T-cell': '186.8', 'Non-switched memory B-cell': '135.8', 'Plasmablast': '315.8', 'Switched memory B-cell': '125.4', 'Exhausted memory B-cell': '129.7', 'Progenitor cell': '130.9', 'Memory T-reg': '101.9', 'Naive CD4 T-cell activated': '125.5', 'Naive CD8 T-cell activated': '148.3', 'Naive T-reg': '57.8'}
5GJQ, 5GJR, 5L4G, 5LN3, 5M32, 5T0C, 5T0G, 5T0H, 5T0I, 5T0J, 5VFP, 5VFQ, 5VFR, 5VFS, 5VFT, 5VFU, 5VGZ, 5VHF, 5VHH, 5VHI, 5VHJ, 5VHM, 5VHN, 5VHO, 5VHP, 5VHQ, 5VHR, 5VHS, 6MSB, 6MSD, 6MSE, 6MSG, 6MSH, 6MSJ, 6MSK, 6WJD, 6WJN, 7QXN, 7QXP, 7QXU, 7QXW, 7QXX, 7QY7, 7QYA, 7QYB, 7W37, 7W38, 7W39, 7W3A, 7W3B, 7W3C, 7W3F, 7W3G, 7W3H, 7W3I, 7W3J, 7W3K, 7W3M, 8CVT
{'Adipose Tissue': 123.53630398671096, 'Adrenal Gland': 104.53697674418603, 'Bladder': 132.75714285714287, 'Blood': 57.491658772874054, 'Blood Vessel': 186.01937078651684, 'Brain': 113.29203255109763, 'Breast': 120.96904139433552, 'Cervix Uteri': 140.43842105263158, 'Colon': 138.03836970474967, 'Esophagus': 147.47575778546712, 'Fallopian Tube': 136.47777777777776, 'Heart': 93.7328037166086, 'Kidney': 68.75505617977528, 'Liver': 71.77450884955752, 'Lung': 138.5949134948097, 'Muscle': 201.02277708592777, 'Nerve': 171.75360258481422, 'Ovary': 107.72922222222222, 'Pancreas': 46.06743902439025, 'Pituitary': 93.5783038869258, 'Prostate': 124.4195918367347, 'Salivary Gland': 99.14666666666666, 'Skin': 163.94273631840795, 'Small Intestine': 91.98604278074866, 'Spleen': 99.75186721991702, 'Stomach': 103.69130919220056, 'Testis': 152.06293628808865, 'Thyroid': 133.6210719754977, 'Uterus': 163.85084507042254, 'Vagina': 123.28378205128206}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
80.466629
0.414237
1,812
O60260
P18206
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
VCL
MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ
Homo sapiens
Cell membrane, Cell junction, adherens junction, Cell junction, focal adhesion, Cytoplasm, cytoskeleton, Cell membrane, sarcolemma, Cell projection, podosome
Low tissue specificity
{'Ciliated cells': '48.2', 'Basal respiratory cells': '69.9', 'Club cells': '56.0', 'Ionocytes': '57.4', 'Mucus glandular cells': '94.1', 'Serous glandular cells': '60.8', 'Gastric mucus-secreting cells': '65.4', 'Proximal enterocytes': '13.4', 'Paneth cells': '35.6', 'Distal enterocytes': '75.2', 'Intestinal goblet cells': '36.3', 'Exocrine glandular cells': '-0.393', 'Basal prostatic cells': '23.5', 'Prostatic glandular cells': '18.6', 'Breast glandular cells': '0.166', 'Breast myoepithelial cells': '0.496', 'Glandular and luminal cells': '119.2', 'Secretory cells': '101.3', 'Basal keratinocytes': '95.9', 'Suprabasal keratinocytes': '80.3', 'Basal squamous epithelial cells': '29.5', 'Squamous epithelial cells': '45.9', 'Alveolar cells type 1': '0.261', 'Alveolar cells type 2': '-0.102', 'Salivary duct cells': '71.4', 'Ductal cells': '0.540', 'Hepatocytes': '0.260', 'Cholangiocytes': '34.3', 'Proximal tubular cells': '0.121', 'Distal tubular cells': '9.2', 'Collecting duct cells': '38.9', 'Mesothelial cells': '0.103', 'Sertoli cells': '0.783', 'Granulosa cells': '19.7', 'Enteroendocrine cells': '42.3', 'Pancreatic endocrine cells': '54.3', 'Leydig cells': '0.677', 'Excitatory neurons': '61.1', 'Inhibitory neurons': '45.5', 'Cone photoreceptor cells': '39.1', 'Rod photoreceptor cells': '39.1', 'Bipolar cells': '17.1', 'Horizontal cells': '11.3', 'Astrocytes': '53.6', 'Oligodendrocyte precursor cells': '17.5', 'Oligodendrocytes': '4.2', 'Microglial cells': '52.8', 'Muller glia cells': '14.6', 'Schwann cells': '0.260', 'Spermatogonia': '0.591', 'Spermatocytes': '0.264', 'Early spermatids': '-0.529', 'Late spermatids': '-0.705', 'Oocytes': '9.6', 'Cytotrophoblasts': '54.4', 'Syncytiotrophoblasts': '41.9', 'Extravillous trophoblasts': '80.1', 'Endothelial cells': '56.2', 'Lymphatic endothelial cells': '52.5', 'Cardiomyocytes': '0.659', 'Skeletal myocytes': '-0.051', 'Smooth muscle cells': '181.4', 'Adipocytes': '63.0', 'Melanocytes': '0.185', 'Fibroblasts': '68.7', 'Peritubular cells': '0.456', 'Endometrial stromal cells': '154.7', 'Ovarian stromal cells': '42.5', 'Undifferentiated cells': '32.7', 'T-cells': '15.6', 'B-cells': '20.4', 'Plasma cells': '9.5', 'Nk-cells': '50.0', 'Granulocytes': '56.4', 'Monocytes': '168.7', 'Macrophages': '33.0', 'Hofbauer cells': '24.6', 'Kupffer cells': '37.1', 'Dendritic cells': '50.0', 'Langerhans cells': '0.139', 'Erythroid cells': '0.118', 'Adipocytes (Subcutaneous)': '-0.498', 'Adipocytes (Visceral)': '-0.202', 'Breast glandular cells (progenitors)': '0.080', 'Adipocytes (Breast)': '-0.268', 'Colon enterocytes': '-0.134', 'Colon enteroendocrine cells': '0.139', 'Enteric glia cells': '-0.173', 'Mitotic cells (Colon)': '-0.111', 'Mitotic cells (Heart)': '0.480', 'Podocytes': '-0.109', 'Ascending Loop of Henle cells': '0.448', 'Intercalated cells': '-0.058', 'Cholangiocyte': '0.502', 'NK-cells (Liver)': '-0.222', 'Respiratory ciliated cells': '-0.035', 'Mitotic cells (Lung)': '-0.071', 'NK-cells (Lung)': '0.245', 'B-cells (Lung)': '-0.021', 'Alpha cells': '0.316', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.401', 'Prostate basal glandular cells': '-0.218', 'Urothelial cells': '-0.238', 'Keratinocyte (other)': '0.038', 'Keratinocyte (granular)': '-0.226', 'Hair cortex cells': '0.221', 'Inner root sheath cells': '0.282', 'Outer root sheath cells': '0.366', 'Sebaceous gland cells': '0.046', 'Eccrine sweat gland cells': '0.175', 'Adipocytes (Skin)': '0.082', 'Mitotic cells (Skin)': '0.411', 'Parietal cells': '-0.730', 'Chief cells': '-0.630', 'Gastric mucous cells': '-0.522', 'Gastric enteroendocrine cells': '-0.495', 'Mitotic cells (Stomach)': '-0.092', 'Parafollicular cells': '0.035', 'Thyroid glandular cells': '0.182', 'Mitotic cells (Thyroid)': '0.117', 'Adrenal cortex cells': '0.473', 'Adrenal medulla cells': '0.162', 'Mitotic cells (Adrenal gland)': '0.300', 'Minor salivary glandular cells': '0.591', 'Minor salivary gland ductal cells': '0.019', 'Minor salivary gland basal cells': '0.345', 'Mitotic cells (Minor salivary gland)': '0.443', 'Adipocytes (Minor salivary gland)': '0.257', 'Somatotropes': '-0.265', 'Lactotropes': '-0.331', 'Gonadotropes': '0.122', 'Corticotropes': '-0.322', 'Thyrotropes': '-0.068', 'Undifferentiated cells (Pituitary gland)': '0.421', 'Mitotic cells (Spleen)': '-0.238', 'Platelets': '0.129', 'Erythrocytes': '0.036', 'Hematopoietic stem cells': '-0.056', 'B-cells (Spleen)': '-0.022', 'NK-cells (Spleen)': '0.100', 'Amygdala excitatory': '72.5', 'Cerebellar inhibitory': '43.7', 'Cge interneuron': '38.1', 'Deep-layer corticothalamic and 6b': '58.1', 'Deep-layer intratelencephalic': '58.7', 'Deep-layer near-projecting': '33.7', 'Eccentric medium spiny neuron': '75.8', 'Hippocampal ca1-3': '93.1', 'Hippocampal ca4': '76.8', 'Hippocampal dentate gyrus': '71.5', 'Lamp5-lhx6 and chandelier': '67.6', 'Lower rhombic lip': '53.1', 'Mammillary body': '65.0', 'Medium spiny neuron': '78.6', 'Mge interneuron': '68.3', 'Midbrain-derived inhibitory': '19.8', 'Miscellaneous': '51.7', 'Splatter': '56.4', 'Thalamic excitatory': '69.2', 'Upper rhombic lip': '70.9', 'Upper-layer intratelencephalic': '78.1', 'Astrocyte': '91.0', 'Bergmann glia': '56.4', 'Central nervous system macrophage': '82.6', 'Choroid plexus epithelial cell': '99.0', 'Committed oligodendrocyte precursor': '28.6', 'Ependymal cell': '84.1', 'Oligodendrocyte': '6.3', 'Oligodendrocyte precursor cell': '32.1', 'Endothelial cell': '147.7', 'Pericyte': '313.1', 'Vascular associated smooth muscle cell': '474.8', 'Fibroblast': '163.4', 'Leukocyte': '102.5', 'Basophil': '199.8', 'Eosinophil': '36.3', 'Neutrophil': '127.6', 'Classical monocyte': '69.5', 'Non-classical monocyte': '105.1', 'Intermediate monocyte': '155.4', 'T-reg': '32.2', 'GdT-cell': '14.9', 'MAIT T-cell': '56.7', 'Memory CD4 T-cell': '7.1', 'Naive CD4 T-cell': '17.8', 'Memory CD8 T-cell': '7.8', 'Naive CD8 T-cell': '9.7', 'Memory B-cell': '5.6', 'Naive B-cell': '20.7', 'Plasmacytoid DC': '113.2', 'Myeloid DC': '129.0', 'NK-cell': '98.4', 'Total PBMC': '121.4', 'Vd2 gdTCR': '62.7', 'Memory CD4 T-cell Th1\\/Th17': '64.4', 'Memory CD4 T-cell Th17': '76.0', 'Memory CD4 T-cell Th2': '50.4', 'Non-Vd2 gdTCR': '81.6', 'Memory CD4 T-cell Th1': '40.6', 'Memory CD4 T-cell TFH': '36.0', 'Terminal effector memory CD4 T-cell': '134.3', 'Central memory CD8 T-cell': '35.0', 'Effector memory CD8 T-cell': '74.6', 'Terminal effector memory CD8 T-cell': '101.3', 'Non-switched memory B-cell': '46.6', 'Plasmablast': '16.6', 'Switched memory B-cell': '50.4', 'Exhausted memory B-cell': '36.6', 'Progenitor cell': '82.9', 'Memory T-reg': '31.0', 'Naive CD4 T-cell activated': '4.4', 'Naive CD8 T-cell activated': '4.1', 'Naive T-reg': '16.6'}
1RKC, 1RKE, 1SYQ, 1TR2, 1YDI, 2GWW, 2HSQ, 2IBF, 3H2U, 3H2V, 3JBK, 3MYI, 3RF3, 3S90, 3TJ5, 3TJ6, 3VF0, 4DJ9, 4EHP, 4LN2, 4LNP, 4PR9, 5L0C, 5L0D, 5L0F, 5L0G, 5L0H, 5L0I, 5L0J, 5O2Q, 6FUY, 6UPW, 7KTT, 7KTU, 7KTV, 7KTW
{'Adipose Tissue': 83.484219269103, 'Adrenal Gland': 17.2004496124031, 'Bladder': 194.49190476190475, 'Blood': 19.07888137782562, 'Blood Vessel': 282.63898876404494, 'Brain': 8.236747501892506, 'Breast': 67.49050108932462, 'Cervix Uteri': 131.9878947368421, 'Colon': 182.8004749679076, 'Esophagus': 156.16977162629755, 'Fallopian Tube': 130.18555555555557, 'Heart': 61.75932520325203, 'Kidney': 25.387359550561797, 'Liver': 7.885022123893806, 'Lung': 111.16482698961936, 'Muscle': 83.76521793275218, 'Nerve': 87.1335056542811, 'Ovary': 73.85783333333333, 'Pancreas': 12.293838414634148, 'Pituitary': 21.84202473498233, 'Prostate': 108.36965306122448, 'Salivary Gland': 38.797777777777775, 'Skin': 81.15232172470978, 'Small Intestine': 69.7263101604278, 'Spleen': 40.17311203319502, 'Stomach': 77.44966852367688, 'Testis': 52.150027700831025, 'Thyroid': 57.2366921898928, 'Uterus': 237.99661971830983, 'Vagina': 91.61314102564104}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
87.025767
0.339101
383
O60260
P19174
18671761
UbiNet, UbiBrowser
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PLCG1
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
Homo sapiens
Cell projection, lamellipodium, Cell projection, ruffle
Low tissue specificity
{'Ciliated cells': '3.0', 'Basal respiratory cells': '4.9', 'Club cells': '3.6', 'Ionocytes': '5.9', 'Mucus glandular cells': '5.5', 'Serous glandular cells': '2.4', 'Gastric mucus-secreting cells': '13.0', 'Proximal enterocytes': '6.3', 'Paneth cells': '5.6', 'Distal enterocytes': '5.9', 'Intestinal goblet cells': '9.9', 'Exocrine glandular cells': '-0.378', 'Basal prostatic cells': '6.8', 'Prostatic glandular cells': '6.4', 'Breast glandular cells': '0.452', 'Breast myoepithelial cells': '0.340', 'Glandular and luminal cells': '8.3', 'Secretory cells': '1.9', 'Basal keratinocytes': '5.5', 'Suprabasal keratinocytes': '5.8', 'Basal squamous epithelial cells': '10.2', 'Squamous epithelial cells': '5.0', 'Alveolar cells type 1': '0.182', 'Alveolar cells type 2': '-0.472', 'Salivary duct cells': '6.4', 'Ductal cells': '0.496', 'Hepatocytes': '0.165', 'Cholangiocytes': '1.9', 'Proximal tubular cells': '0.153', 'Distal tubular cells': '0.0', 'Collecting duct cells': '3.9', 'Mesothelial cells': '0.305', 'Sertoli cells': '0.223', 'Granulosa cells': '3.8', 'Enteroendocrine cells': '4.1', 'Pancreatic endocrine cells': '1.7', 'Leydig cells': '0.231', 'Excitatory neurons': '9.4', 'Inhibitory neurons': '8.7', 'Cone photoreceptor cells': '6.8', 'Rod photoreceptor cells': '4.4', 'Bipolar cells': '3.0', 'Horizontal cells': '6.3', 'Astrocytes': '65.6', 'Oligodendrocyte precursor cells': '12.3', 'Oligodendrocytes': '15.3', 'Microglial cells': '16.1', 'Muller glia cells': '6.4', 'Schwann cells': '0.207', 'Spermatogonia': '0.444', 'Spermatocytes': '0.459', 'Early spermatids': '-0.183', 'Late spermatids': '-0.311', 'Oocytes': '5.9', 'Cytotrophoblasts': '1.9', 'Syncytiotrophoblasts': '1.1', 'Extravillous trophoblasts': '1.8', 'Endothelial cells': '27.6', 'Lymphatic endothelial cells': '26.1', 'Cardiomyocytes': '0.339', 'Skeletal myocytes': '-0.243', 'Smooth muscle cells': '8.7', 'Adipocytes': '32.2', 'Melanocytes': '-0.015', 'Fibroblasts': '11.0', 'Peritubular cells': '0.333', 'Endometrial stromal cells': '14.9', 'Ovarian stromal cells': '7.7', 'Undifferentiated cells': '4.3', 'T-cells': '21.1', 'B-cells': '5.7', 'Plasma cells': '5.1', 'Nk-cells': '3.5', 'Granulocytes': '3.2', 'Monocytes': '0.7', 'Macrophages': '2.0', 'Hofbauer cells': '3.3', 'Kupffer cells': '2.6', 'Dendritic cells': '0.4', 'Langerhans cells': '-0.019', 'Erythroid cells': '0.060', 'Adipocytes (Subcutaneous)': '-0.322', 'Adipocytes (Visceral)': '-0.419', 'Breast glandular cells (progenitors)': '0.267', 'Adipocytes (Breast)': '-0.402', 'Colon enterocytes': '-0.110', 'Colon enteroendocrine cells': '0.262', 'Enteric glia cells': '0.419', 'Mitotic cells (Colon)': '-0.126', 'Mitotic cells (Heart)': '0.418', 'Podocytes': '-0.128', 'Ascending Loop of Henle cells': '0.373', 'Intercalated cells': '-0.140', 'Cholangiocyte': '0.374', 'NK-cells (Liver)': '-0.062', 'Respiratory ciliated cells': '0.079', 'Mitotic cells (Lung)': '-0.142', 'NK-cells (Lung)': '0.341', 'B-cells (Lung)': '0.153', 'Alpha cells': '0.423', 'Beta cells': '0.310', 'Prostate glandular cells': '-0.304', 'Prostate basal glandular cells': '0.043', 'Urothelial cells': '0.147', 'Keratinocyte (other)': '-0.048', 'Keratinocyte (granular)': '-0.247', 'Hair cortex cells': '0.144', 'Inner root sheath cells': '0.146', 'Outer root sheath cells': '0.404', 'Sebaceous gland cells': '-0.043', 'Eccrine sweat gland cells': '0.048', 'Adipocytes (Skin)': '-0.038', 'Mitotic cells (Skin)': '0.227', 'Parietal cells': '-0.677', 'Chief cells': '-0.661', 'Gastric mucous cells': '-0.494', 'Gastric enteroendocrine cells': '-0.421', 'Mitotic cells (Stomach)': '-0.108', 'Parafollicular cells': '-0.043', 'Thyroid glandular cells': '0.296', 'Mitotic cells (Thyroid)': '-0.077', 'Adrenal cortex cells': '0.297', 'Adrenal medulla cells': '-0.030', 'Mitotic cells (Adrenal gland)': '0.212', 'Minor salivary glandular cells': '0.403', 'Minor salivary gland ductal cells': '0.297', 'Minor salivary gland basal cells': '0.141', 'Mitotic cells (Minor salivary gland)': '0.097', 'Adipocytes (Minor salivary gland)': '0.199', 'Somatotropes': '-0.257', 'Lactotropes': '-0.273', 'Gonadotropes': '0.064', 'Corticotropes': '-0.315', 'Thyrotropes': '-0.072', 'Undifferentiated cells (Pituitary gland)': '0.543', 'Mitotic cells (Spleen)': '-0.239', 'Platelets': '-0.211', 'Erythrocytes': '-0.049', 'Hematopoietic stem cells': '-0.317', 'B-cells (Spleen)': '0.435', 'NK-cells (Spleen)': '0.354', 'Amygdala excitatory': '20.8', 'Cerebellar inhibitory': '18.0', 'Cge interneuron': '22.4', 'Deep-layer corticothalamic and 6b': '21.6', 'Deep-layer intratelencephalic': '20.6', 'Deep-layer near-projecting': '20.3', 'Eccentric medium spiny neuron': '25.2', 'Hippocampal ca1-3': '18.8', 'Hippocampal ca4': '23.7', 'Hippocampal dentate gyrus': '23.4', 'Lamp5-lhx6 and chandelier': '21.5', 'Lower rhombic lip': '21.0', 'Mammillary body': '21.6', 'Medium spiny neuron': '26.9', 'Mge interneuron': '20.8', 'Midbrain-derived inhibitory': '14.2', 'Miscellaneous': '18.5', 'Splatter': '20.3', 'Thalamic excitatory': '21.7', 'Upper rhombic lip': '40.8', 'Upper-layer intratelencephalic': '22.9', 'Astrocyte': '93.6', 'Bergmann glia': '107.1', 'Central nervous system macrophage': '13.9', 'Choroid plexus epithelial cell': '15.7', 'Committed oligodendrocyte precursor': '31.5', 'Ependymal cell': '22.8', 'Oligodendrocyte': '45.5', 'Oligodendrocyte precursor cell': '40.2', 'Endothelial cell': '66.7', 'Pericyte': '12.1', 'Vascular associated smooth muscle cell': '22.8', 'Fibroblast': '31.5', 'Leukocyte': '48.6', 'Basophil': '0.0', 'Eosinophil': '0.0', 'Neutrophil': '0.5', 'Classical monocyte': '1.2', 'Non-classical monocyte': '0.7', 'Intermediate monocyte': '0.5', 'T-reg': '81.0', 'GdT-cell': '4.7', 'MAIT T-cell': '91.5', 'Memory CD4 T-cell': '4.1', 'Naive CD4 T-cell': '245.1', 'Memory CD8 T-cell': '3.9', 'Naive CD8 T-cell': '302.7', 'Memory B-cell': '0.2', 'Naive B-cell': '36.3', 'Plasmacytoid DC': '1.2', 'Myeloid DC': '0.0', 'NK-cell': '93.4', 'Total PBMC': '22.1', 'Vd2 gdTCR': '65.5', 'Memory CD4 T-cell Th1\\/Th17': '220.3', 'Memory CD4 T-cell Th17': '252.7', 'Memory CD4 T-cell Th2': '254.0', 'Non-Vd2 gdTCR': '37.4', 'Memory CD4 T-cell Th1': '255.4', 'Memory CD4 T-cell TFH': '294.2', 'Terminal effector memory CD4 T-cell': '46.9', 'Central memory CD8 T-cell': '82.9', 'Effector memory CD8 T-cell': '56.0', 'Terminal effector memory CD8 T-cell': '38.2', 'Non-switched memory B-cell': '8.8', 'Plasmablast': '1.7', 'Switched memory B-cell': '5.0', 'Exhausted memory B-cell': '8.9', 'Progenitor cell': '3.7', 'Memory T-reg': '328.6', 'Naive CD4 T-cell activated': '40.0', 'Naive CD8 T-cell activated': '56.6', 'Naive T-reg': '259.2'}
1HSQ, 2HSP, 4EY0, 4FBN, 7NXE
{'Adipose Tissue': 50.96083056478405, 'Adrenal Gland': 27.33750387596899, 'Bladder': 51.21619047619048, 'Blood': 17.629483423035524, 'Blood Vessel': 46.63618651685393, 'Brain': 40.25761165783497, 'Breast': 53.47065359477124, 'Cervix Uteri': 87.53315789473683, 'Colon': 35.630504492939664, 'Esophagus': 40.43072802768166, 'Fallopian Tube': 64.47555555555556, 'Heart': 19.66252729384437, 'Kidney': 24.26584269662921, 'Liver': 6.249402654867256, 'Lung': 61.27811418685121, 'Muscle': 13.09290909090909, 'Nerve': 70.38667205169628, 'Ovary': 80.90027777777777, 'Pancreas': 7.613365853658538, 'Pituitary': 37.241731448763254, 'Prostate': 53.32424489795918, 'Salivary Gland': 28.471543209876547, 'Skin': 43.83182531785517, 'Small Intestine': 44.4920320855615, 'Spleen': 47.92323651452282, 'Stomach': 24.86525905292479, 'Testis': 55.185013850415515, 'Thyroid': 91.0143797856049, 'Uterus': 85.57197183098592, 'Vagina': 59.95967948717948}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
82.872295
0.355543
280
O60260
P19367
23068103, 23503661
UbiNet, UbiBrowser, DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
HK1
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Homo sapiens
Mitochondrion outer membrane, Cytoplasm, cytosol
Low tissue specificity
{'Ciliated cells': '32.6', 'Basal respiratory cells': '35.3', 'Club cells': '38.5', 'Ionocytes': '26.9', 'Mucus glandular cells': '28.6', 'Serous glandular cells': '48.8', 'Gastric mucus-secreting cells': '38.9', 'Proximal enterocytes': '0.5', 'Paneth cells': '10.9', 'Distal enterocytes': '28.5', 'Intestinal goblet cells': '28.5', 'Exocrine glandular cells': '-0.686', 'Basal prostatic cells': '44.2', 'Prostatic glandular cells': '60.3', 'Breast glandular cells': '0.429', 'Breast myoepithelial cells': '0.276', 'Glandular and luminal cells': '32.5', 'Secretory cells': '15.4', 'Basal keratinocytes': '86.4', 'Suprabasal keratinocytes': '122.9', 'Basal squamous epithelial cells': '52.5', 'Squamous epithelial cells': '89.2', 'Alveolar cells type 1': '0.022', 'Alveolar cells type 2': '0.137', 'Salivary duct cells': '47.5', 'Ductal cells': '0.677', 'Hepatocytes': '0.305', 'Cholangiocytes': '5.7', 'Proximal tubular cells': '-0.065', 'Distal tubular cells': '18.4', 'Collecting duct cells': '23.3', 'Mesothelial cells': '-0.138', 'Sertoli cells': '-0.471', 'Granulosa cells': '19.5', 'Enteroendocrine cells': '15.1', 'Pancreatic endocrine cells': '27.2', 'Leydig cells': '-0.524', 'Excitatory neurons': '52.0', 'Inhibitory neurons': '47.8', 'Cone photoreceptor cells': '90.1', 'Rod photoreceptor cells': '76.7', 'Bipolar cells': '83.1', 'Horizontal cells': '125.3', 'Astrocytes': '36.2', 'Oligodendrocyte precursor cells': '13.2', 'Oligodendrocytes': '3.2', 'Microglial cells': '27.7', 'Muller glia cells': '29.5', 'Schwann cells': '0.212', 'Spermatogonia': '-0.236', 'Spermatocytes': '0.049', 'Early spermatids': '0.653', 'Late spermatids': '0.784', 'Oocytes': '3.7', 'Cytotrophoblasts': '69.5', 'Syncytiotrophoblasts': '115.0', 'Extravillous trophoblasts': '97.4', 'Endothelial cells': '34.2', 'Lymphatic endothelial cells': '26.6', 'Cardiomyocytes': '0.673', 'Skeletal myocytes': '-0.229', 'Smooth muscle cells': '32.4', 'Adipocytes': '25.1', 'Melanocytes': '0.229', 'Fibroblasts': '30.0', 'Peritubular cells': '-0.348', 'Endometrial stromal cells': '27.4', 'Ovarian stromal cells': '7.1', 'Undifferentiated cells': '11.2', 'T-cells': '33.1', 'B-cells': '25.3', 'Plasma cells': '17.6', 'Nk-cells': '18.1', 'Granulocytes': '32.8', 'Monocytes': '66.8', 'Macrophages': '48.5', 'Hofbauer cells': '50.9', 'Kupffer cells': '41.5', 'Dendritic cells': '4.1', 'Langerhans cells': '0.191', 'Erythroid cells': '0.050', 'Adipocytes (Subcutaneous)': '-0.028', 'Adipocytes (Visceral)': '-0.126', 'Breast glandular cells (progenitors)': '0.135', 'Adipocytes (Breast)': '-0.318', 'Colon enterocytes': '-0.107', 'Colon enteroendocrine cells': '0.158', 'Enteric glia cells': '-0.341', 'Mitotic cells (Colon)': '-0.080', 'Mitotic cells (Heart)': '0.488', 'Podocytes': '-0.189', 'Ascending Loop of Henle cells': '0.377', 'Intercalated cells': '-0.177', 'Cholangiocyte': '0.528', 'NK-cells (Liver)': '-0.215', 'Respiratory ciliated cells': '-0.105', 'Mitotic cells (Lung)': '0.118', 'NK-cells (Lung)': '0.003', 'B-cells (Lung)': '-0.131', 'Alpha cells': '0.337', 'Beta cells': '0.136', 'Prostate glandular cells': '0.045', 'Prostate basal glandular cells': '0.307', 'Urothelial cells': '0.110', 'Keratinocyte (other)': '0.653', 'Keratinocyte (granular)': '0.167', 'Hair cortex cells': '-0.240', 'Inner root sheath cells': '-0.199', 'Outer root sheath cells': '-0.228', 'Sebaceous gland cells': '-0.223', 'Eccrine sweat gland cells': '-0.377', 'Adipocytes (Skin)': '-0.477', 'Mitotic cells (Skin)': '0.178', 'Parietal cells': '-0.455', 'Chief cells': '-0.570', 'Gastric mucous cells': '-0.112', 'Gastric enteroendocrine cells': '-0.481', 'Mitotic cells (Stomach)': '0.240', 'Parafollicular cells': '0.115', 'Thyroid glandular cells': '0.504', 'Mitotic cells (Thyroid)': '-0.164', 'Adrenal cortex cells': '0.237', 'Adrenal medulla cells': '0.193', 'Mitotic cells (Adrenal gland)': '0.219', 'Minor salivary glandular cells': '0.087', 'Minor salivary gland ductal cells': '-0.173', 'Minor salivary gland basal cells': '0.721', 'Mitotic cells (Minor salivary gland)': '0.659', 'Adipocytes (Minor salivary gland)': '0.326', 'Somatotropes': '0.018', 'Lactotropes': '0.014', 'Gonadotropes': '0.090', 'Corticotropes': '-0.054', 'Thyrotropes': '0.096', 'Undifferentiated cells (Pituitary gland)': '0.172', 'Mitotic cells (Spleen)': '-0.169', 'Platelets': '0.095', 'Erythrocytes': '-0.074', 'Hematopoietic stem cells': '0.014', 'B-cells (Spleen)': '0.130', 'NK-cells (Spleen)': '0.058', 'Amygdala excitatory': '100.0', 'Cerebellar inhibitory': '110.4', 'Cge interneuron': '81.7', 'Deep-layer corticothalamic and 6b': '106.7', 'Deep-layer intratelencephalic': '116.4', 'Deep-layer near-projecting': '107.1', 'Eccentric medium spiny neuron': '91.2', 'Hippocampal ca1-3': '93.7', 'Hippocampal ca4': '94.7', 'Hippocampal dentate gyrus': '90.3', 'Lamp5-lhx6 and chandelier': '87.4', 'Lower rhombic lip': '78.7', 'Mammillary body': '97.0', 'Medium spiny neuron': '74.2', 'Mge interneuron': '97.8', 'Midbrain-derived inhibitory': '72.9', 'Miscellaneous': '106.4', 'Splatter': '84.0', 'Thalamic excitatory': '73.0', 'Upper rhombic lip': '100.1', 'Upper-layer intratelencephalic': '98.5', 'Astrocyte': '70.0', 'Bergmann glia': '71.5', 'Central nervous system macrophage': '107.6', 'Choroid plexus epithelial cell': '176.5', 'Committed oligodendrocyte precursor': '20.6', 'Ependymal cell': '136.9', 'Oligodendrocyte': '3.8', 'Oligodendrocyte precursor cell': '27.2', 'Endothelial cell': '65.2', 'Pericyte': '83.1', 'Vascular associated smooth muscle cell': '92.6', 'Fibroblast': '57.5', 'Leukocyte': '85.6', 'Basophil': '185.5', 'Eosinophil': '44.5', 'Neutrophil': '110.9', 'Classical monocyte': '127.7', 'Non-classical monocyte': '224.6', 'Intermediate monocyte': '376.9', 'T-reg': '133.8', 'GdT-cell': '41.3', 'MAIT T-cell': '195.0', 'Memory CD4 T-cell': '47.9', 'Naive CD4 T-cell': '75.5', 'Memory CD8 T-cell': '47.7', 'Naive CD8 T-cell': '72.8', 'Memory B-cell': '33.1', 'Naive B-cell': '32.3', 'Plasmacytoid DC': '29.9', 'Myeloid DC': '212.1', 'NK-cell': '59.5', 'Total PBMC': '185.9', 'Vd2 gdTCR': '116.4', 'Memory CD4 T-cell Th1\\/Th17': '96.1', 'Memory CD4 T-cell Th17': '112.9', 'Memory CD4 T-cell Th2': '111.5', 'Non-Vd2 gdTCR': '119.0', 'Memory CD4 T-cell Th1': '89.3', 'Memory CD4 T-cell TFH': '98.2', 'Terminal effector memory CD4 T-cell': '111.4', 'Central memory CD8 T-cell': '133.5', 'Effector memory CD8 T-cell': '134.7', 'Terminal effector memory CD8 T-cell': '115.9', 'Non-switched memory B-cell': '127.2', 'Plasmablast': '55.1', 'Switched memory B-cell': '128.0', 'Exhausted memory B-cell': '104.8', 'Progenitor cell': '91.6', 'Memory T-reg': '115.5', 'Naive CD4 T-cell activated': '118.4', 'Naive CD8 T-cell activated': '129.5', 'Naive T-reg': '70.3'}
1CZA, 1DGK, 1HKB, 1HKC, 1QHA, 4F9O, 4FOE, 4FOI, 4FPA, 4FPB
{'Adipose Tissue': 49.867433554817275, 'Adrenal Gland': 22.95891085271318, 'Bladder': 96.82333333333334, 'Blood': 49.77777825618945, 'Blood Vessel': 105.28752808988764, 'Brain': 65.18826570779711, 'Breast': 50.439433551198256, 'Cervix Uteri': 64.74578947368421, 'Colon': 58.27415917843389, 'Esophagus': 103.47295640138408, 'Fallopian Tube': 56.02, 'Heart': 76.44933101045295, 'Kidney': 24.82375280898876, 'Liver': 3.946217699115044, 'Lung': 66.51368512110727, 'Muscle': 98.91911581569116, 'Nerve': 43.64924071082391, 'Ovary': 28.471611111111113, 'Pancreas': 5.886263109756097, 'Pituitary': 57.22618374558304, 'Prostate': 69.79057142857143, 'Salivary Gland': 68.31012345679012, 'Skin': 108.72415146489772, 'Small Intestine': 33.957903743315505, 'Spleen': 45.90477178423236, 'Stomach': 56.266, 'Testis': 98.76445983379502, 'Thyroid': 94.38137825421131, 'Uterus': 55.6562676056338, 'Vagina': 102.09192307692308}
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0.35, 0.15, 0.42, 0.12, 0.53, 0.01, 0.5, 0.25, 0.38, 0.03, 0.0, 0.0, 0.0, 0.12, 0.0, 0.2, 0.29, 0.54, 0.65, 0.0, 0.17, 0.02, 0.0, 0.03, 0.0, 0.26, 0.0, 0.42, 0.42, 0.64, 1.0, 0.85, 0.53, 0.5, 0.33, 0.45, 0.3, 0.36, 0.43, 0.3, 0.63, 0.12, 0.68, 0.04, 0.42, 0.52, 0.76, 0.22, 0.04, 0.48, 0.18, 0.35, 0.04, 0.56, 0.51, 0.0, 0.01, 0.34, 0.22, 0.0, 0.01, 0.37, 0.05, 0.0, 0.02, 0.39, 0.0, 0.03, 0.55, 0.68, 0.27, 0.76, 0.22, 0.31, 0.83, 0.65, 0.62, 0.1, 0.22, 0.0, 0.0, 0.0, 0.0, 0.01, 0.1, 0.01, 0.08, 0.08, 0.49, 0.15, 0.63, 0.32, 0.15, 0.24, 0.18, 0.0, 0.38, 0.01, 0.38, 0.53, 0.12, 0.1, 0.12, 0.21, 0.03, 0.47, 0.04, 0.52, 0.67, 0.01, 0.48, 0.62, 0.46, 0.2, 0.0, 0.0, 0.42, 0.17, 0.0, 0.32, 0.36, 0.02, 0.06, 0.68, 0.44, 0.37, 0.84, 0.52, 0.14, 0.54, 0.06, 0.26, 0.01, 0.02, 0.0, 0.03, 0.05, 0.08, 0.2, 0.0, 0.02, 0.0, 0.0, 0.0, 0.0, 0.06, 0.07, 0.05, 0.11, 0.79, 0.32, 0.77, 0.36, 0.0, 0.15, 0.0, 0.0, 0.0, 0.13, 0.0, 0.05, 0.43, 0.13, 0.03, 0.09, 0.0, 0.0, 0.0, 0.03, 0.0, 0.23, 0.01, 0.63, 0.28, 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0.42, 0.58, 0.04, 0.41, 0.14, 0.0, 0.21, 0.6, 0.1, 0.0, 0.35, 0.5, 0.08, 0.01, 0.75, 0.5, 0.05, 0.0, 0.69, 0.53, 0.07, 0.47, 0.22, 0.45, 0.18, 0.39, 0.48, 0.05, 0.8, 0.31, 0.0, 0.06, 0.0, 0.13, 0.0, 0.0, 0.0, 0.0, 0.02, 0.0, 0.08, 0.11, 0.06, 0.35, 0.24, 0.38, 0.36, 0.61, 0.48, 0.77, 0.8, 0.76]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
94.534635
0.256412
620
O60260
P21796
22199232, hUbiquitome, 33082525, 23503661
UbiNet, UbiBrowser, 31181401, DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
VDAC1
MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA
Homo sapiens
Mitochondrion outer membrane, Cell membrane, Membrane raft
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '106.7', 'Basal respiratory cells': '227.0', 'Club cells': '141.4', 'Ionocytes': '121.9', 'Mucus glandular cells': '101.3', 'Serous glandular cells': '151.9', 'Gastric mucus-secreting cells': '235.2', 'Proximal enterocytes': '428.5', 'Paneth cells': '221.9', 'Distal enterocytes': '406.7', 'Intestinal goblet cells': '157.9', 'Exocrine glandular cells': '-0.728', 'Basal prostatic cells': '153.2', 'Prostatic glandular cells': '125.1', 'Breast glandular cells': '0.090', 'Breast myoepithelial cells': '-0.087', 'Glandular and luminal cells': '198.5', 'Secretory cells': '134.5', 'Basal keratinocytes': '229.0', 'Suprabasal keratinocytes': '321.4', 'Basal squamous epithelial cells': '169.8', 'Squamous epithelial cells': '283.7', 'Alveolar cells type 1': '-0.152', 'Alveolar cells type 2': '0.062', 'Salivary duct cells': '140.4', 'Ductal cells': '0.663', 'Hepatocytes': '0.417', 'Cholangiocytes': '177.4', 'Proximal tubular cells': '0.386', 'Distal tubular cells': '639.3', 'Collecting duct cells': '138.1', 'Mesothelial cells': '-0.073', 'Sertoli cells': '0.742', 'Granulosa cells': '113.9', 'Enteroendocrine cells': '192.1', 'Pancreatic endocrine cells': '373.6', 'Leydig cells': '0.720', 'Excitatory neurons': '40.1', 'Inhibitory neurons': '38.9', 'Cone photoreceptor cells': '295.7', 'Rod photoreceptor cells': '150.7', 'Bipolar cells': '419.0', 'Horizontal cells': '310.3', 'Astrocytes': '20.1', 'Oligodendrocyte precursor cells': '22.6', 'Oligodendrocytes': '22.2', 'Microglial cells': '30.4', 'Muller glia cells': '237.4', 'Schwann cells': '-0.004', 'Spermatogonia': '0.523', 'Spermatocytes': '0.128', 'Early spermatids': '-0.476', 'Late spermatids': '-0.690', 'Oocytes': '112.5', 'Cytotrophoblasts': '395.0', 'Syncytiotrophoblasts': '288.3', 'Extravillous trophoblasts': '466.5', 'Endothelial cells': '98.5', 'Lymphatic endothelial cells': '109.7', 'Cardiomyocytes': '0.783', 'Skeletal myocytes': '0.358', 'Smooth muscle cells': '125.2', 'Adipocytes': '82.0', 'Melanocytes': '0.227', 'Fibroblasts': '140.0', 'Peritubular cells': '0.506', 'Endometrial stromal cells': '160.7', 'Ovarian stromal cells': '74.6', 'Undifferentiated cells': '293.8', 'T-cells': '102.8', 'B-cells': '95.2', 'Plasma cells': '174.7', 'Nk-cells': '82.1', 'Granulocytes': '126.3', 'Monocytes': '209.0', 'Macrophages': '153.3', 'Hofbauer cells': '299.3', 'Kupffer cells': '109.8', 'Dendritic cells': '70.0', 'Langerhans cells': '0.143', 'Erythroid cells': '-0.066', 'Adipocytes (Subcutaneous)': '0.305', 'Adipocytes (Visceral)': '0.265', 'Breast glandular cells (progenitors)': '-0.057', 'Adipocytes (Breast)': '0.057', 'Colon enterocytes': '0.089', 'Colon enteroendocrine cells': '0.103', 'Enteric glia cells': '-0.134', 'Mitotic cells (Colon)': '0.223', 'Mitotic cells (Heart)': '0.430', 'Podocytes': '0.210', 'Ascending Loop of Henle cells': '0.288', 'Intercalated cells': '0.213', 'Cholangiocyte': '0.363', 'NK-cells (Liver)': '-0.430', 'Respiratory ciliated cells': '-0.094', 'Mitotic cells (Lung)': '0.229', 'NK-cells (Lung)': '-0.206', 'B-cells (Lung)': '-0.204', 'Alpha cells': '0.377', 'Beta cells': '0.178', 'Prostate glandular cells': '0.170', 'Prostate basal glandular cells': '0.205', 'Urothelial cells': '0.096', 'Keratinocyte (other)': '0.334', 'Keratinocyte (granular)': '-0.066', 'Hair cortex cells': '0.039', 'Inner root sheath cells': '0.132', 'Outer root sheath cells': '0.086', 'Sebaceous gland cells': '0.127', 'Eccrine sweat gland cells': '-0.069', 'Adipocytes (Skin)': '-0.207', 'Mitotic cells (Skin)': '0.329', 'Parietal cells': '0.455', 'Chief cells': '0.276', 'Gastric mucous cells': '0.679', 'Gastric enteroendocrine cells': '0.291', 'Mitotic cells (Stomach)': '0.539', 'Parafollicular cells': '0.094', 'Thyroid glandular cells': '0.303', 'Mitotic cells (Thyroid)': '0.005', 'Adrenal cortex cells': '0.566', 'Adrenal medulla cells': '0.011', 'Mitotic cells (Adrenal gland)': '0.192', 'Minor salivary glandular cells': '0.140', 'Minor salivary gland ductal cells': '-0.296', 'Minor salivary gland basal cells': '0.623', 'Mitotic cells (Minor salivary gland)': '0.708', 'Adipocytes (Minor salivary gland)': '0.212', 'Somatotropes': '-0.467', 'Lactotropes': '-0.205', 'Gonadotropes': '0.012', 'Corticotropes': '0.030', 'Thyrotropes': '0.173', 'Undifferentiated cells (Pituitary gland)': '0.481', 'Mitotic cells (Spleen)': '0.152', 'Platelets': '-0.074', 'Erythrocytes': '-0.081', 'Hematopoietic stem cells': '-0.058', 'B-cells (Spleen)': '0.144', 'NK-cells (Spleen)': '-0.035', 'Amygdala excitatory': '47.0', 'Cerebellar inhibitory': '99.3', 'Cge interneuron': '65.8', 'Deep-layer corticothalamic and 6b': '55.3', 'Deep-layer intratelencephalic': '59.9', 'Deep-layer near-projecting': '59.9', 'Eccentric medium spiny neuron': '56.7', 'Hippocampal ca1-3': '56.0', 'Hippocampal ca4': '84.9', 'Hippocampal dentate gyrus': '52.3', 'Lamp5-lhx6 and chandelier': '69.4', 'Lower rhombic lip': '81.1', 'Mammillary body': '77.4', 'Medium spiny neuron': '58.7', 'Mge interneuron': '62.5', 'Midbrain-derived inhibitory': '86.1', 'Miscellaneous': '74.4', 'Splatter': '71.4', 'Thalamic excitatory': '75.3', 'Upper rhombic lip': '68.2', 'Upper-layer intratelencephalic': '60.3', 'Astrocyte': '30.5', 'Bergmann glia': '41.4', 'Central nervous system macrophage': '69.3', 'Choroid plexus epithelial cell': '79.6', 'Committed oligodendrocyte precursor': '45.4', 'Ependymal cell': '56.7', 'Oligodendrocyte': '30.8', 'Oligodendrocyte precursor cell': '47.8', 'Endothelial cell': '41.4', 'Pericyte': '45.8', 'Vascular associated smooth muscle cell': '56.1', 'Fibroblast': '33.4', 'Leukocyte': '33.1', 'Basophil': '38.0', 'Eosinophil': '30.4', 'Neutrophil': '13.1', 'Classical monocyte': '93.0', 'Non-classical monocyte': '125.9', 'Intermediate monocyte': '271.3', 'T-reg': '120.2', 'GdT-cell': '54.6', 'MAIT T-cell': '163.5', 'Memory CD4 T-cell': '55.7', 'Naive CD4 T-cell': '49.7', 'Memory CD8 T-cell': '57.3', 'Naive CD8 T-cell': '42.7', 'Memory B-cell': '58.5', 'Naive B-cell': '39.8', 'Plasmacytoid DC': '148.4', 'Myeloid DC': '356.0', 'NK-cell': '74.2', 'Total PBMC': '160.1', 'Vd2 gdTCR': '138.0', 'Memory CD4 T-cell Th1\\/Th17': '77.8', 'Memory CD4 T-cell Th17': '76.9', 'Memory CD4 T-cell Th2': '71.5', 'Non-Vd2 gdTCR': '173.7', 'Memory CD4 T-cell Th1': '63.9', 'Memory CD4 T-cell TFH': '64.2', 'Terminal effector memory CD4 T-cell': '151.1', 'Central memory CD8 T-cell': '132.7', 'Effector memory CD8 T-cell': '180.0', 'Terminal effector memory CD8 T-cell': '157.8', 'Non-switched memory B-cell': '114.6', 'Plasmablast': '399.7', 'Switched memory B-cell': '189.3', 'Exhausted memory B-cell': '161.1', 'Progenitor cell': '156.2', 'Memory T-reg': '70.2', 'Naive CD4 T-cell activated': '304.6', 'Naive CD8 T-cell activated': '282.8', 'Naive T-reg': '49.0'}
2JK4, 2K4T, 5JDP, 5XDN, 5XDO, 6G6U, 6G73, 6TIQ, 6TIR, 7QI2, 8J0O
{'Adipose Tissue': 97.51971760797343, 'Adrenal Gland': 119.55104651162792, 'Bladder': 103.30857142857144, 'Blood': 98.56667814854684, 'Blood Vessel': 108.75246441947566, 'Brain': 111.7165098410295, 'Breast': 91.15420479302831, 'Cervix Uteri': 78.23842105263158, 'Colon': 101.72327342747111, 'Esophagus': 118.05557093425604, 'Fallopian Tube': 80.13888888888889, 'Heart': 164.28348432055748, 'Kidney': 114.151797752809, 'Liver': 87.0141592920354, 'Lung': 108.65842560553634, 'Muscle': 391.2288916562889, 'Nerve': 85.05313408723748, 'Ovary': 85.49494444444444, 'Pancreas': 42.47103658536585, 'Pituitary': 81.96360424028269, 'Prostate': 97.79485714285715, 'Salivary Gland': 113.48172839506174, 'Skin': 172.97153676064124, 'Small Intestine': 110.04732620320854, 'Spleen': 68.12821576763486, 'Stomach': 119.20877437325905, 'Testis': 56.069252077562325, 'Thyroid': 92.60699846860643, 'Uterus': 74.135, 'Vagina': 114.25326923076922}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
93.366042
0.383922
2,404
O60260
P21860
15632191
UbiNet, UbiBrowser
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ERBB3
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT
Homo sapiens
Cell membrane, Secreted
Low tissue specificity
{'Ciliated cells': '45.5', 'Basal respiratory cells': '22.5', 'Club cells': '102.6', 'Ionocytes': '63.0', 'Mucus glandular cells': '116.3', 'Serous glandular cells': '112.1', 'Gastric mucus-secreting cells': '93.7', 'Proximal enterocytes': '207.6', 'Paneth cells': '156.0', 'Distal enterocytes': '151.0', 'Intestinal goblet cells': '153.9', 'Exocrine glandular cells': '-0.567', 'Basal prostatic cells': '27.5', 'Prostatic glandular cells': '99.5', 'Breast glandular cells': '0.847', 'Breast myoepithelial cells': '0.511', 'Glandular and luminal cells': '86.1', 'Secretory cells': '34.6', 'Basal keratinocytes': '33.4', 'Suprabasal keratinocytes': '71.3', 'Basal squamous epithelial cells': '42.3', 'Squamous epithelial cells': '90.5', 'Alveolar cells type 1': '0.450', 'Alveolar cells type 2': '0.653', 'Salivary duct cells': '51.9', 'Ductal cells': '0.555', 'Hepatocytes': '0.383', 'Cholangiocytes': '169.8', 'Proximal tubular cells': '0.547', 'Distal tubular cells': '3.1', 'Collecting duct cells': '35.0', 'Mesothelial cells': '0.649', 'Sertoli cells': '0.172', 'Granulosa cells': '0.5', 'Enteroendocrine cells': '116.1', 'Pancreatic endocrine cells': '8.5', 'Leydig cells': '0.217', 'Excitatory neurons': '0.7', 'Inhibitory neurons': '1.9', 'Cone photoreceptor cells': '0.0', 'Rod photoreceptor cells': '1.3', 'Bipolar cells': '1.1', 'Horizontal cells': '1.9', 'Astrocytes': '0.9', 'Oligodendrocyte precursor cells': '46.7', 'Oligodendrocytes': '174.1', 'Microglial cells': '0.9', 'Muller glia cells': '6.2', 'Schwann cells': '0.866', 'Spermatogonia': '0.359', 'Spermatocytes': '0.530', 'Early spermatids': '-0.128', 'Late spermatids': '-0.219', 'Oocytes': '0.0', 'Cytotrophoblasts': '54.3', 'Syncytiotrophoblasts': '109.3', 'Extravillous trophoblasts': '94.5', 'Endothelial cells': '4.0', 'Lymphatic endothelial cells': '3.0', 'Cardiomyocytes': '0.488', 'Skeletal myocytes': '0.245', 'Smooth muscle cells': '5.2', 'Adipocytes': '1.9', 'Melanocytes': '-0.015', 'Fibroblasts': '5.7', 'Peritubular cells': '0.157', 'Endometrial stromal cells': '10.2', 'Ovarian stromal cells': '0.8', 'Undifferentiated cells': '104.7', 'T-cells': '2.9', 'B-cells': '0.9', 'Plasma cells': '2.7', 'Nk-cells': '0.7', 'Granulocytes': '1.2', 'Monocytes': '0.0', 'Macrophages': '2.7', 'Hofbauer cells': '2.2', 'Kupffer cells': '4.9', 'Dendritic cells': '0.0', 'Langerhans cells': '0.112', 'Erythroid cells': '-0.020', 'Adipocytes (Subcutaneous)': '-0.289', 'Adipocytes (Visceral)': '-0.257', 'Breast glandular cells (progenitors)': '0.550', 'Adipocytes (Breast)': '-0.615', 'Colon enterocytes': '0.202', 'Colon enteroendocrine cells': '0.200', 'Enteric glia cells': '0.620', 'Mitotic cells (Colon)': '0.047', 'Mitotic cells (Heart)': '0.299', 'Podocytes': '0.104', 'Ascending Loop of Henle cells': '0.215', 'Intercalated cells': '0.128', 'Cholangiocyte': '-0.084', 'NK-cells (Liver)': '0.036', 'Respiratory ciliated cells': '0.117', 'Mitotic cells (Lung)': '-0.002', 'NK-cells (Lung)': '-0.188', 'B-cells (Lung)': '-0.218', 'Alpha cells': '0.279', 'Beta cells': '0.140', 'Prostate glandular cells': '0.590', 'Prostate basal glandular cells': '0.525', 'Urothelial cells': '0.263', 'Keratinocyte (other)': '0.283', 'Keratinocyte (granular)': '0.451', 'Hair cortex cells': '-0.177', 'Inner root sheath cells': '-0.174', 'Outer root sheath cells': '-0.204', 'Sebaceous gland cells': '0.024', 'Eccrine sweat gland cells': '-0.241', 'Adipocytes (Skin)': '-0.111', 'Mitotic cells (Skin)': '0.005', 'Parietal cells': '0.612', 'Chief cells': '0.536', 'Gastric mucous cells': '0.761', 'Gastric enteroendocrine cells': '0.578', 'Mitotic cells (Stomach)': '0.376', 'Parafollicular cells': '-0.013', 'Thyroid glandular cells': '0.108', 'Mitotic cells (Thyroid)': '-0.095', 'Adrenal cortex cells': '0.126', 'Adrenal medulla cells': '0.550', 'Mitotic cells (Adrenal gland)': '0.150', 'Minor salivary glandular cells': '0.584', 'Minor salivary gland ductal cells': '0.037', 'Minor salivary gland basal cells': '0.083', 'Mitotic cells (Minor salivary gland)': '0.193', 'Adipocytes (Minor salivary gland)': '-0.119', 'Somatotropes': '-0.216', 'Lactotropes': '-0.185', 'Gonadotropes': '-0.065', 'Corticotropes': '-0.133', 'Thyrotropes': '0.058', 'Undifferentiated cells (Pituitary gland)': '0.410', 'Mitotic cells (Spleen)': '0.097', 'Platelets': '0.026', 'Erythrocytes': '0.003', 'Hematopoietic stem cells': '-0.050', 'B-cells (Spleen)': '0.204', 'NK-cells (Spleen)': '-0.010', 'Amygdala excitatory': '6.2', 'Cerebellar inhibitory': '2.2', 'Cge interneuron': '1.5', 'Deep-layer corticothalamic and 6b': '1.3', 'Deep-layer intratelencephalic': '0.9', 'Deep-layer near-projecting': '6.6', 'Eccentric medium spiny neuron': '1.2', 'Hippocampal ca1-3': '1.0', 'Hippocampal ca4': '0.7', 'Hippocampal dentate gyrus': '14.0', 'Lamp5-lhx6 and chandelier': '0.9', 'Lower rhombic lip': '2.2', 'Mammillary body': '1.2', 'Medium spiny neuron': '1.5', 'Mge interneuron': '4.4', 'Midbrain-derived inhibitory': '0.6', 'Miscellaneous': '9.2', 'Splatter': '2.1', 'Thalamic excitatory': '1.4', 'Upper rhombic lip': '1.3', 'Upper-layer intratelencephalic': '1.6', 'Astrocyte': '4.8', 'Bergmann glia': '7.9', 'Central nervous system macrophage': '4.2', 'Choroid plexus epithelial cell': '10.6', 'Committed oligodendrocyte precursor': '315.9', 'Ependymal cell': '2.5', 'Oligodendrocyte': '330.4', 'Oligodendrocyte precursor cell': '87.7', 'Endothelial cell': '3.1', 'Pericyte': '3.2', 'Vascular associated smooth muscle cell': '2.5', 'Fibroblast': '3.9', 'Leukocyte': '6.6', 'Basophil': '1.9', 'Eosinophil': '0.1', 'Neutrophil': '3.1', 'Classical monocyte': '0.0', 'Non-classical monocyte': '0.1', 'Intermediate monocyte': '0.9', 'T-reg': '1.6', 'GdT-cell': '0.1', 'MAIT T-cell': '2.0', 'Memory CD4 T-cell': '0.1', 'Naive CD4 T-cell': '0.9', 'Memory CD8 T-cell': '0.0', 'Naive CD8 T-cell': '2.6', 'Memory B-cell': '0.0', 'Naive B-cell': '0.1', 'Plasmacytoid DC': '0.7', 'Myeloid DC': '0.6', 'NK-cell': '0.3', 'Total PBMC': '0.7', 'Vd2 gdTCR': '1.2', 'Memory CD4 T-cell Th1\\/Th17': '1.2', 'Memory CD4 T-cell Th17': '0.4', 'Memory CD4 T-cell Th2': '0.4', 'Non-Vd2 gdTCR': '1.5', 'Memory CD4 T-cell Th1': '1.2', 'Memory CD4 T-cell TFH': '0.5', 'Terminal effector memory CD4 T-cell': '1.2', 'Central memory CD8 T-cell': '2.0', 'Effector memory CD8 T-cell': '1.8', 'Terminal effector memory CD8 T-cell': '1.2', 'Non-switched memory B-cell': '1.7', 'Plasmablast': '0.4', 'Switched memory B-cell': '1.5', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '1.1', 'Memory T-reg': '0.6', 'Naive CD4 T-cell activated': '1.0', 'Naive CD8 T-cell activated': '2.6', 'Naive T-reg': '1.3'}
1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4P59, 4RIW, 4RIX, 4RIY, 5CUS, 5O4O, 5O7P, 6KBI, 6OP9, 7BHE, 7BHF, 7D85, 7MN5, 7MN6, 7MN8
{'Adipose Tissue': 2.3008836877076413, 'Adrenal Gland': 0.9487278294573644, 'Bladder': 25.60119047619047, 'Blood': 0.1082347082884822, 'Blood Vessel': 2.453802129588015, 'Brain': 14.20401896290689, 'Breast': 30.94611098039216, 'Cervix Uteri': 19.55547368421053, 'Colon': 35.85655584082157, 'Esophagus': 34.01696332179931, 'Fallopian Tube': 7.758111111111112, 'Heart': 2.9367721602787453, 'Kidney': 18.393449438202246, 'Liver': 33.997827433628316, 'Lung': 20.344531660899655, 'Muscle': 1.276661917808219, 'Nerve': 124.11210016155088, 'Ovary': 1.9042777777777775, 'Pancreas': 22.232506097560975, 'Pituitary': 2.473519434628975, 'Prostate': 39.386991836734694, 'Salivary Gland': 62.52296296296296, 'Skin': 52.372110026534, 'Small Intestine': 46.869445454545456, 'Spleen': 0.2683490456431535, 'Stomach': 46.50203064066852, 'Testis': 2.8948512465373963, 'Thyroid': 11.5731, 'Uterus': 2.8969140845070425, 'Vagina': 46.60019871794872}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
72.392168
0.493107
258
O60260
P22392
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
NME2
MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE
Homo sapiens
Cytoplasm, Cell projection, lamellipodium, Cell projection, ruffle, Cytoplasm, Cytoplasm, perinuclear region, Nucleus, Cytoplasm, Cytoplasm, perinuclear region, Nucleus
Low tissue specificity
{'Ciliated cells': '5.0', 'Basal respiratory cells': '18.1', 'Club cells': '8.9', 'Ionocytes': '9.6', 'Mucus glandular cells': '4.3', 'Serous glandular cells': '8.3', 'Gastric mucus-secreting cells': '428.6', 'Proximal enterocytes': '3.9', 'Paneth cells': '5.7', 'Distal enterocytes': '8.2', 'Intestinal goblet cells': '8.3', 'Exocrine glandular cells': '-0.702', 'Basal prostatic cells': '6.7', 'Prostatic glandular cells': '6.2', 'Breast glandular cells': '0.247', 'Breast myoepithelial cells': '0.125', 'Glandular and luminal cells': '17.4', 'Secretory cells': '9.6', 'Basal keratinocytes': '29.9', 'Suprabasal keratinocytes': '37.0', 'Basal squamous epithelial cells': '998.8', 'Squamous epithelial cells': '1241.1', 'Alveolar cells type 1': '-0.333', 'Alveolar cells type 2': '-0.058', 'Salivary duct cells': '9.1', 'Ductal cells': '0.627', 'Hepatocytes': '0.348', 'Cholangiocytes': '9.5', 'Proximal tubular cells': '0.199', 'Distal tubular cells': '46.1', 'Collecting duct cells': '5.8', 'Mesothelial cells': '0.189', 'Sertoli cells': '0.582', 'Granulosa cells': '7.2', 'Enteroendocrine cells': '10.6', 'Pancreatic endocrine cells': '18.7', 'Leydig cells': '0.747', 'Excitatory neurons': '0.0', 'Inhibitory neurons': '0.0', 'Cone photoreceptor cells': '3.4', 'Rod photoreceptor cells': '1.0', 'Bipolar cells': '0.9', 'Horizontal cells': '0.6', 'Astrocytes': '0.0', 'Oligodendrocyte precursor cells': '0.0', 'Oligodendrocytes': '0.0', 'Microglial cells': '0.0', 'Muller glia cells': '0.5', 'Schwann cells': '0.038', 'Spermatogonia': '0.444', 'Spermatocytes': '-0.064', 'Early spermatids': '-0.588', 'Late spermatids': '-0.661', 'Oocytes': '2.2', 'Cytotrophoblasts': '8.0', 'Syncytiotrophoblasts': '5.9', 'Extravillous trophoblasts': '18.6', 'Endothelial cells': '44.4', 'Lymphatic endothelial cells': '7.5', 'Cardiomyocytes': '0.462', 'Skeletal myocytes': '-0.423', 'Smooth muscle cells': '36.5', 'Adipocytes': '5.9', 'Melanocytes': '0.043', 'Fibroblasts': '60.4', 'Peritubular cells': '0.552', 'Endometrial stromal cells': '26.1', 'Ovarian stromal cells': '11.4', 'Undifferentiated cells': '11.7', 'T-cells': '62.2', 'B-cells': '131.2', 'Plasma cells': '479.2', 'Nk-cells': '4.7', 'Granulocytes': '4.7', 'Monocytes': '12.4', 'Macrophages': '92.9', 'Hofbauer cells': '10.9', 'Kupffer cells': '14.3', 'Dendritic cells': '9.0', 'Langerhans cells': '-0.012', 'Erythroid cells': '-0.120', 'Adipocytes (Subcutaneous)': '-0.075', 'Adipocytes (Visceral)': '-0.057', 'Breast glandular cells (progenitors)': '0.232', 'Adipocytes (Breast)': '-0.152', 'Colon enterocytes': '-0.211', 'Colon enteroendocrine cells': '-0.041', 'Enteric glia cells': '0.041', 'Mitotic cells (Colon)': '0.064', 'Mitotic cells (Heart)': '0.539', 'Podocytes': '-0.015', 'Ascending Loop of Henle cells': '0.314', 'Intercalated cells': '-0.044', 'Cholangiocyte': '0.384', 'NK-cells (Liver)': '-0.459', 'Respiratory ciliated cells': '-0.105', 'Mitotic cells (Lung)': '0.196', 'NK-cells (Lung)': '-0.311', 'B-cells (Lung)': '-0.225', 'Alpha cells': '0.274', 'Beta cells': '0.165', 'Prostate glandular cells': '-0.318', 'Prostate basal glandular cells': '0.090', 'Urothelial cells': '0.194', 'Keratinocyte (other)': '0.057', 'Keratinocyte (granular)': '-0.079', 'Hair cortex cells': '-0.005', 'Inner root sheath cells': '0.045', 'Outer root sheath cells': '0.001', 'Sebaceous gland cells': '0.076', 'Eccrine sweat gland cells': '-0.105', 'Adipocytes (Skin)': '-0.123', 'Mitotic cells (Skin)': '0.041', 'Parietal cells': '-0.595', 'Chief cells': '-0.389', 'Gastric mucous cells': '-0.194', 'Gastric enteroendocrine cells': '-0.271', 'Mitotic cells (Stomach)': '0.285', 'Parafollicular cells': '0.001', 'Thyroid glandular cells': '0.152', 'Mitotic cells (Thyroid)': '0.004', 'Adrenal cortex cells': '0.269', 'Adrenal medulla cells': '-0.075', 'Mitotic cells (Adrenal gland)': '0.008', 'Minor salivary glandular cells': '0.204', 'Minor salivary gland ductal cells': '-0.071', 'Minor salivary gland basal cells': '0.420', 'Mitotic cells (Minor salivary gland)': '0.427', 'Adipocytes (Minor salivary gland)': '0.180', 'Somatotropes': '0.088', 'Lactotropes': '-0.262', 'Gonadotropes': '-0.225', 'Corticotropes': '-0.273', 'Thyrotropes': '-0.077', 'Undifferentiated cells (Pituitary gland)': '0.167', 'Mitotic cells (Spleen)': '-0.177', 'Platelets': '-0.226', 'Erythrocytes': '-0.144', 'Hematopoietic stem cells': '-0.178', 'B-cells (Spleen)': '0.156', 'NK-cells (Spleen)': '-0.037', 'Amygdala excitatory': '26.4', 'Cerebellar inhibitory': '44.2', 'Cge interneuron': '47.6', 'Deep-layer corticothalamic and 6b': '33.2', 'Deep-layer intratelencephalic': '37.0', 'Deep-layer near-projecting': '34.5', 'Eccentric medium spiny neuron': '23.8', 'Hippocampal ca1-3': '42.8', 'Hippocampal ca4': '91.9', 'Hippocampal dentate gyrus': '58.9', 'Lamp5-lhx6 and chandelier': '51.6', 'Lower rhombic lip': '107.2', 'Mammillary body': '47.6', 'Medium spiny neuron': '27.1', 'Mge interneuron': '43.0', 'Midbrain-derived inhibitory': '30.2', 'Miscellaneous': '52.7', 'Splatter': '52.1', 'Thalamic excitatory': '54.8', 'Upper rhombic lip': '45.4', 'Upper-layer intratelencephalic': '40.2', 'Astrocyte': '26.8', 'Bergmann glia': '31.9', 'Central nervous system macrophage': '55.0', 'Choroid plexus epithelial cell': '113.6', 'Committed oligodendrocyte precursor': '53.3', 'Ependymal cell': '30.5', 'Oligodendrocyte': '45.7', 'Oligodendrocyte precursor cell': '31.6', 'Endothelial cell': '72.3', 'Pericyte': '80.9', 'Vascular associated smooth muscle cell': '85.5', 'Fibroblast': '47.7', 'Leukocyte': '41.5', 'Basophil': '8.1', 'Eosinophil': '14.1', 'Neutrophil': '0.2', 'Classical monocyte': '1.3', 'Non-classical monocyte': '2.1', 'Intermediate monocyte': '164.3', 'T-reg': '98.0', 'GdT-cell': '167.2', 'MAIT T-cell': '101.0', 'Memory CD4 T-cell': '212.6', 'Naive CD4 T-cell': '0.9', 'Memory CD8 T-cell': '183.4', 'Naive CD8 T-cell': '1.0', 'Memory B-cell': '340.3', 'Naive B-cell': '1.2', 'Plasmacytoid DC': '175.9', 'Myeloid DC': '234.9', 'NK-cell': '1.2', 'Total PBMC': '116.5', 'Vd2 gdTCR': '135.0', 'Memory CD4 T-cell Th1\\/Th17': '0.9', 'Memory CD4 T-cell Th17': '0.9', 'Memory CD4 T-cell Th2': '0.9', 'Non-Vd2 gdTCR': '75.5', 'Memory CD4 T-cell Th1': '0.7', 'Memory CD4 T-cell TFH': '0.8', 'Terminal effector memory CD4 T-cell': '43.3', 'Central memory CD8 T-cell': '95.5', 'Effector memory CD8 T-cell': '47.4', 'Terminal effector memory CD8 T-cell': '108.9', 'Non-switched memory B-cell': '101.2', 'Plasmablast': '311.9', 'Switched memory B-cell': '143.7', 'Exhausted memory B-cell': '161.1', 'Progenitor cell': '106.2', 'Memory T-reg': '0.8', 'Naive CD4 T-cell activated': '11.5', 'Naive CD8 T-cell activated': '10.4', 'Naive T-reg': '0.7'}
1NSK, 1NUE, 3BBB, 3BBC, 3BBF, 7KPF, 8PYW
{'Adipose Tissue': 395.4166943521595, 'Adrenal Gland': 288.4317829457364, 'Bladder': 424.45238095238096, 'Blood': 180.60152206673845, 'Blood Vessel': 410.39176029962545, 'Brain': 142.3336298258895, 'Breast': 423.0930283224401, 'Cervix Uteri': 456.0578947368421, 'Colon': 309.57406931964056, 'Esophagus': 376.2157785467128, 'Fallopian Tube': 387.1555555555556, 'Heart': 148.3532055749129, 'Kidney': 245.0952808988764, 'Liver': 150.66402654867255, 'Lung': 337.93771626297575, 'Muscle': 208.19144458281448, 'Nerve': 366.8907915993538, 'Ovary': 499.72166666666664, 'Pancreas': 204.26868902439023, 'Pituitary': 224.36890459363957, 'Prostate': 345.32081632653063, 'Salivary Gland': 320.8117283950617, 'Skin': 512.2782752902156, 'Small Intestine': 245.98508021390373, 'Spleen': 274.37427385892113, 'Stomach': 258.7041782729805, 'Testis': 90.6976731301939, 'Thyroid': 327.3486983154671, 'Uterus': 433.1330985915493, 'Vagina': 436.6269230769231}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
97.654276
0.352039
2,616
O60260
P23396
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
RPS3
MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPVPTA
Homo sapiens
Cytoplasm, Nucleus, Nucleus, nucleolus, Mitochondrion inner membrane, Cytoplasm, cytoskeleton, spindle
Low tissue specificity
{'Ciliated cells': '1298.9', 'Basal respiratory cells': '5245.5', 'Club cells': '2878.6', 'Ionocytes': '1948.6', 'Mucus glandular cells': '1314.6', 'Serous glandular cells': '2667.9', 'Gastric mucus-secreting cells': '1706.2', 'Proximal enterocytes': '2700.1', 'Paneth cells': '4262.5', 'Distal enterocytes': '2760.5', 'Intestinal goblet cells': '4402.3', 'Exocrine glandular cells': '-0.746', 'Basal prostatic cells': '2298.5', 'Prostatic glandular cells': '2349.5', 'Breast glandular cells': '0.606', 'Breast myoepithelial cells': '0.501', 'Glandular and luminal cells': '1567.0', 'Secretory cells': '6815.6', 'Basal keratinocytes': '5285.4', 'Suprabasal keratinocytes': '6573.4', 'Basal squamous epithelial cells': '5438.4', 'Squamous epithelial cells': '5514.0', 'Alveolar cells type 1': '-0.149', 'Alveolar cells type 2': '-0.036', 'Salivary duct cells': '2358.6', 'Ductal cells': '0.600', 'Hepatocytes': '0.037', 'Cholangiocytes': '2045.2', 'Proximal tubular cells': '0.096', 'Distal tubular cells': '1994.7', 'Collecting duct cells': '793.5', 'Mesothelial cells': '0.480', 'Sertoli cells': '0.607', 'Granulosa cells': '6039.8', 'Enteroendocrine cells': '4240.4', 'Pancreatic endocrine cells': '2957.9', 'Leydig cells': '0.633', 'Excitatory neurons': '27.3', 'Inhibitory neurons': '31.2', 'Cone photoreceptor cells': '693.2', 'Rod photoreceptor cells': '369.2', 'Bipolar cells': '428.6', 'Horizontal cells': '113.9', 'Astrocytes': '17.6', 'Oligodendrocyte precursor cells': '18.4', 'Oligodendrocytes': '44.2', 'Microglial cells': '36.7', 'Muller glia cells': '938.4', 'Schwann cells': '0.079', 'Spermatogonia': '0.374', 'Spermatocytes': '-0.159', 'Early spermatids': '-0.539', 'Late spermatids': '-0.572', 'Oocytes': '999.9', 'Cytotrophoblasts': '6817.3', 'Syncytiotrophoblasts': '5641.3', 'Extravillous trophoblasts': '9839.9', 'Endothelial cells': '2673.5', 'Lymphatic endothelial cells': '2130.2', 'Cardiomyocytes': '0.469', 'Skeletal myocytes': '-0.157', 'Smooth muscle cells': '2638.2', 'Adipocytes': '2333.8', 'Melanocytes': '0.052', 'Fibroblasts': '2272.5', 'Peritubular cells': '0.511', 'Endometrial stromal cells': '3217.0', 'Ovarian stromal cells': '8480.6', 'Undifferentiated cells': '7575.7', 'T-cells': '5270.8', 'B-cells': '5179.9', 'Plasma cells': '3255.5', 'Nk-cells': '3774.7', 'Granulocytes': '4290.2', 'Monocytes': '2765.7', 'Macrophages': '2143.1', 'Hofbauer cells': '3826.1', 'Kupffer cells': '2608.7', 'Dendritic cells': '2965.2', 'Langerhans cells': '0.155', 'Erythroid cells': '-0.092', 'Adipocytes (Subcutaneous)': '-0.449', 'Adipocytes (Visceral)': '-0.456', 'Breast glandular cells (progenitors)': '0.565', 'Adipocytes (Breast)': '-0.548', 'Colon enterocytes': '-0.244', 'Colon enteroendocrine cells': '0.093', 'Enteric glia cells': '0.285', 'Mitotic cells (Colon)': '-0.125', 'Mitotic cells (Heart)': '0.455', 'Podocytes': '0.047', 'Ascending Loop of Henle cells': '0.332', 'Intercalated cells': '0.061', 'Cholangiocyte': '0.327', 'NK-cells (Liver)': '-0.258', 'Respiratory ciliated cells': '-0.046', 'Mitotic cells (Lung)': '0.056', 'NK-cells (Lung)': '-0.283', 'B-cells (Lung)': '-0.154', 'Alpha cells': '0.313', 'Beta cells': '0.165', 'Prostate glandular cells': '-0.220', 'Prostate basal glandular cells': '0.239', 'Urothelial cells': '0.369', 'Keratinocyte (other)': '0.309', 'Keratinocyte (granular)': '0.060', 'Hair cortex cells': '-0.250', 'Inner root sheath cells': '-0.139', 'Outer root sheath cells': '-0.196', 'Sebaceous gland cells': '0.052', 'Eccrine sweat gland cells': '-0.330', 'Adipocytes (Skin)': '-0.262', 'Mitotic cells (Skin)': '0.095', 'Parietal cells': '-0.621', 'Chief cells': '-0.431', 'Gastric mucous cells': '-0.279', 'Gastric enteroendocrine cells': '-0.293', 'Mitotic cells (Stomach)': '0.111', 'Parafollicular cells': '0.019', 'Thyroid glandular cells': '0.193', 'Mitotic cells (Thyroid)': '0.024', 'Adrenal cortex cells': '0.103', 'Adrenal medulla cells': '-0.007', 'Mitotic cells (Adrenal gland)': '-0.198', 'Minor salivary glandular cells': '0.324', 'Minor salivary gland ductal cells': '0.033', 'Minor salivary gland basal cells': '0.455', 'Mitotic cells (Minor salivary gland)': '0.382', 'Adipocytes (Minor salivary gland)': '0.280', 'Somatotropes': '0.239', 'Lactotropes': '0.139', 'Gonadotropes': '-0.035', 'Corticotropes': '-0.093', 'Thyrotropes': '0.114', 'Undifferentiated cells (Pituitary gland)': '0.046', 'Mitotic cells (Spleen)': '-0.368', 'Platelets': '-0.270', 'Erythrocytes': '-0.257', 'Hematopoietic stem cells': '-0.227', 'B-cells (Spleen)': '0.605', 'NK-cells (Spleen)': '0.190', 'Amygdala excitatory': '50.5', 'Cerebellar inhibitory': '62.6', 'Cge interneuron': '83.1', 'Deep-layer corticothalamic and 6b': '68.8', 'Deep-layer intratelencephalic': '68.6', 'Deep-layer near-projecting': '74.4', 'Eccentric medium spiny neuron': '55.3', 'Hippocampal ca1-3': '42.7', 'Hippocampal ca4': '59.7', 'Hippocampal dentate gyrus': '91.7', 'Lamp5-lhx6 and chandelier': '68.3', 'Lower rhombic lip': '44.7', 'Mammillary body': '37.4', 'Medium spiny neuron': '62.4', 'Mge interneuron': '59.2', 'Midbrain-derived inhibitory': '64.1', 'Miscellaneous': '63.9', 'Splatter': '59.4', 'Thalamic excitatory': '44.3', 'Upper rhombic lip': '107.1', 'Upper-layer intratelencephalic': '60.6', 'Astrocyte': '36.8', 'Bergmann glia': '44.6', 'Central nervous system macrophage': '175.7', 'Choroid plexus epithelial cell': '81.4', 'Committed oligodendrocyte precursor': '78.7', 'Ependymal cell': '60.4', 'Oligodendrocyte': '97.0', 'Oligodendrocyte precursor cell': '60.4', 'Endothelial cell': '153.3', 'Pericyte': '114.5', 'Vascular associated smooth muscle cell': '190.1', 'Fibroblast': '93.3', 'Leukocyte': '412.2', 'Basophil': '195.6', 'Eosinophil': '245.9', 'Neutrophil': '103.8', 'Classical monocyte': '331.3', 'Non-classical monocyte': '289.6', 'Intermediate monocyte': '533.4', 'T-reg': '1598.3', 'GdT-cell': '1408.2', 'MAIT T-cell': '1417.1', 'Memory CD4 T-cell': '1827.6', 'Naive CD4 T-cell': '1348.1', 'Memory CD8 T-cell': '1489.0', 'Naive CD8 T-cell': '1410.2', 'Memory B-cell': '1607.5', 'Naive B-cell': '632.2', 'Plasmacytoid DC': '705.2', 'Myeloid DC': '745.0', 'NK-cell': '586.5', 'Total PBMC': '1134.8', 'Vd2 gdTCR': '1845.0', 'Memory CD4 T-cell Th1\\/Th17': '1281.3', 'Memory CD4 T-cell Th17': '1358.0', 'Memory CD4 T-cell Th2': '1306.6', 'Non-Vd2 gdTCR': '1052.8', 'Memory CD4 T-cell Th1': '1407.8', 'Memory CD4 T-cell TFH': '1448.5', 'Terminal effector memory CD4 T-cell': '1058.5', 'Central memory CD8 T-cell': '1479.1', 'Effector memory CD8 T-cell': '706.6', 'Terminal effector memory CD8 T-cell': '1387.7', 'Non-switched memory B-cell': '1117.0', 'Plasmablast': '784.1', 'Switched memory B-cell': '1156.3', 'Exhausted memory B-cell': '1039.7', 'Progenitor cell': '1074.3', 'Memory T-reg': '1078.1', 'Naive CD4 T-cell activated': '780.9', 'Naive CD8 T-cell activated': '899.5', 'Naive T-reg': '1327.8'}
1WH9, 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 5LKS, 5OA3, 5T2C, 5VYC, 6FEC, 6G51, 6G53, 6G5H, 6G5I, 6IP5, 6IP6, 6IP8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6XA1, 6Y0G, 6Y2L, 6Y57, 6YBS, 6Z6L, 6Z6M, 6Z6N, 6ZLW, 6ZM7, 6ZME, 6ZMI, 6ZMO, 6ZMT, 6ZMW, 6ZN5, 6ZOJ, 6ZOL, 6ZON, 6ZP4, 6ZUO, 6ZV6, 6ZVH, 6ZVJ, 6ZXD, 6ZXE, 6ZXF, 6ZXG, 6ZXH, 7A09, 7K5I, 7QP6, 7QP7, 7QVP, 7R4X, 7TQL, 7XNX, 7XNY, 8G5Y, 8G5Z, 8G60, 8G61, 8G6J, 8GLP, 8IFD, 8IFE, 8JDJ, 8JDK, 8JDL, 8JDM, 8OZ0, 8PPK, 8PPL, 8QOI, 8T4S, 8XXL, 8XXM, 8XXN, 8Y0W, 8Y0X
{'Adipose Tissue': 393.0514950166113, 'Adrenal Gland': 227.2653488372093, 'Bladder': 467.45238095238096, 'Blood': 358.9664262648009, 'Blood Vessel': 385.0052434456929, 'Brain': 108.33327781983348, 'Breast': 504.44422657952066, 'Cervix Uteri': 768.3684210526316, 'Colon': 373.1322207958922, 'Esophagus': 409.9186851211073, 'Fallopian Tube': 625.8333333333334, 'Heart': 127.77997677119627, 'Kidney': 184.32629213483148, 'Liver': 109.04725663716816, 'Lung': 387.01626297577855, 'Muscle': 161.35921544209216, 'Nerve': 424.9641357027463, 'Ovary': 1354.49, 'Pancreas': 267.52259146341464, 'Pituitary': 318.41204946996464, 'Prostate': 451.8089795918367, 'Salivary Gland': 339.4074074074074, 'Skin': 654.4767274737424, 'Small Intestine': 421.1283422459893, 'Spleen': 528.6597510373444, 'Stomach': 315.97465181058493, 'Testis': 166.24886426592798, 'Thyroid': 386.4756508422665, 'Uterus': 671.8570422535211, 'Vagina': 604.9506410256411}
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[46.29, 70.22, 84.46, 86.65, 93.46, 95.25, 95.23, 96.25, 95.69, 94.4, 96.01, 96.87, 94.72, 94.71, 96.42, 96.97, 95.68, 96.53, 97.22, 97.14, 96.38, 96.64, 96.71, 96.86, 95.85, 95.43, 93.71, 93.9, 95.09, 91.23, 91.2, 93.46, 91.79, 95.56, 93.18, 94.22, 95.98, 95.51, 95.7, 94.64, 91.73, 90.48, 87.38, 88.89, 91.54, 94.0, 95.29, 96.02, 96.18, 96.31, 95.61, 95.39, 94.48, 93.05, 94.49, 94.23, 93.86, 94.12, 93.97, 92.43, 94.15, 93.59, 92.96, 95.72, 94.59, 94.59, 94.74, 95.26, 95.62, 94.99, 94.93, 95.58, 94.69, 93.47, 95.34, 95.07, 93.11, 91.13, 90.5, 91.04, 89.34, 88.31, 91.98, 94.5, 94.02, 95.08, 94.72, 95.01, 95.58, 94.79, 92.81, 87.41, 91.19, 92.47, 93.95, 94.8, 94.7, 96.19, 95.75, 94.53, 96.33, 96.5, 95.12, 94.65, 96.57, 96.22, 95.06, 95.81, 95.42, 94.86, 95.07, 93.13, 95.53, 95.36, 95.75, 96.04, 97.06, 97.15, 97.35, 97.73, 96.73, 96.84, 97.02, 97.33, 97.37, 97.34, 96.87, 96.8, 95.63, 94.72, 96.56, 96.2, 97.31, 97.37, 98.08, 98.14, 97.75, 97.49, 96.75, 95.97, 94.62, 89.22, 88.57, 90.63, 92.9, 95.05, 95.94, 96.26, 96.26, 96.26, 97.42, 97.61, 97.41, 97.55, 96.66, 95.72, 96.65, 96.15, 96.44, 96.19, 95.79, 95.43, 96.0, 95.98, 95.23, 94.01, 95.98, 96.82, 95.99, 97.3, 96.94, 97.1, 96.08, 96.66, 95.46, 94.83, 93.78, 92.42, 91.85, 94.08, 96.55, 96.48, 97.66, 97.46, 98.24, 98.01, 98.18, 97.89, 97.22, 96.32, 95.58, 94.4, 91.44, 91.26, 91.69, 87.38, 87.11, 89.08, 88.74, 93.26, 93.72, 92.44, 93.51, 93.61, 93.62, 93.29, 91.0, 93.07, 91.17, 93.46, 92.66, 92.59, 92.06, 91.69, 87.1, 85.22, 84.11, 83.69, 83.32, 85.92, 85.45, 85.9, 81.8, 83.89, 80.46, 73.24, 64.06, 63.06, 49.52, 50.54, 52.43, 52.28, 53.98, 55.03, 49.9, 50.76, 53.11, 57.16, 53.68, 59.78, 56.3, 61.54, 52.85]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
91.00823
0.464568
2,580
O60260
P24539
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ATP5PB
MLSRVVLSAAATAAPSLKNAAFLGPGVLQATRTFHTGQPHLVPVPPLPEYGGKVRYGLIPEEFFQFLYPKTGVTGPYVLGTGLILYALSKEIYVISAETFTALSVLGVMVYGIKKYGPFVADFADKLNEQKLAQLEEAKQASIQHIQNAIDTEKSQQALVQKRHYLFDVQRNNIAMALEVTYRERLYRVYKEVKNRLDYHISVQNMMRRKEQEHMINWVEKHVVQSISTQQEKETIAKCIADLKLLAKKAQAQPVM
Homo sapiens
Mitochondrion, Mitochondrion inner membrane
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '133.0', 'Basal respiratory cells': '496.8', 'Club cells': '186.6', 'Ionocytes': '245.6', 'Mucus glandular cells': '93.4', 'Serous glandular cells': '186.0', 'Gastric mucus-secreting cells': '171.0', 'Proximal enterocytes': '312.7', 'Paneth cells': '183.4', 'Distal enterocytes': '390.6', 'Intestinal goblet cells': '235.6', 'Exocrine glandular cells': '-0.694', 'Basal prostatic cells': '136.4', 'Prostatic glandular cells': '100.5', 'Breast glandular cells': '-0.057', 'Breast myoepithelial cells': '-0.111', 'Glandular and luminal cells': '134.6', 'Secretory cells': '176.7', 'Basal keratinocytes': '182.1', 'Suprabasal keratinocytes': '227.9', 'Basal squamous epithelial cells': '178.6', 'Squamous epithelial cells': '273.7', 'Alveolar cells type 1': '-0.153', 'Alveolar cells type 2': '0.233', 'Salivary duct cells': '132.2', 'Ductal cells': '0.563', 'Hepatocytes': '0.581', 'Cholangiocytes': '104.9', 'Proximal tubular cells': '0.328', 'Distal tubular cells': '408.8', 'Collecting duct cells': '126.4', 'Mesothelial cells': '0.129', 'Sertoli cells': '-0.023', 'Granulosa cells': '89.3', 'Enteroendocrine cells': '231.8', 'Pancreatic endocrine cells': '229.2', 'Leydig cells': '-0.049', 'Excitatory neurons': '23.1', 'Inhibitory neurons': '30.8', 'Cone photoreceptor cells': '137.6', 'Rod photoreceptor cells': '64.1', 'Bipolar cells': '79.5', 'Horizontal cells': '60.4', 'Astrocytes': '26.3', 'Oligodendrocyte precursor cells': '20.3', 'Oligodendrocytes': '30.5', 'Microglial cells': '16.1', 'Muller glia cells': '152.8', 'Schwann cells': '0.035', 'Spermatogonia': '0.160', 'Spermatocytes': '0.430', 'Early spermatids': '0.663', 'Late spermatids': '0.191', 'Oocytes': '316.1', 'Cytotrophoblasts': '370.0', 'Syncytiotrophoblasts': '357.5', 'Extravillous trophoblasts': '427.4', 'Endothelial cells': '111.3', 'Lymphatic endothelial cells': '101.1', 'Cardiomyocytes': '0.824', 'Skeletal myocytes': '0.258', 'Smooth muscle cells': '119.3', 'Adipocytes': '76.0', 'Melanocytes': '0.178', 'Fibroblasts': '132.5', 'Peritubular cells': '-0.088', 'Endometrial stromal cells': '112.4', 'Ovarian stromal cells': '127.8', 'Undifferentiated cells': '375.2', 'T-cells': '121.2', 'B-cells': '131.0', 'Plasma cells': '194.1', 'Nk-cells': '111.6', 'Granulocytes': '156.4', 'Monocytes': '192.1', 'Macrophages': '171.9', 'Hofbauer cells': '381.0', 'Kupffer cells': '203.4', 'Dendritic cells': '149.2', 'Langerhans cells': '0.242', 'Erythroid cells': '-0.076', 'Adipocytes (Subcutaneous)': '0.079', 'Adipocytes (Visceral)': '0.242', 'Breast glandular cells (progenitors)': '-0.068', 'Adipocytes (Breast)': '0.225', 'Colon enterocytes': '0.085', 'Colon enteroendocrine cells': '0.002', 'Enteric glia cells': '-0.430', 'Mitotic cells (Colon)': '0.196', 'Mitotic cells (Heart)': '0.377', 'Podocytes': '0.094', 'Ascending Loop of Henle cells': '0.409', 'Intercalated cells': '0.197', 'Cholangiocyte': '0.325', 'NK-cells (Liver)': '-0.383', 'Respiratory ciliated cells': '-0.077', 'Mitotic cells (Lung)': '0.357', 'NK-cells (Lung)': '-0.260', 'B-cells (Lung)': '-0.281', 'Alpha cells': '0.351', 'Beta cells': '0.190', 'Prostate glandular cells': '-0.009', 'Prostate basal glandular cells': '0.142', 'Urothelial cells': '0.050', 'Keratinocyte (other)': '0.113', 'Keratinocyte (granular)': '-0.210', 'Hair cortex cells': '0.109', 'Inner root sheath cells': '0.207', 'Outer root sheath cells': '0.319', 'Sebaceous gland cells': '0.314', 'Eccrine sweat gland cells': '0.076', 'Adipocytes (Skin)': '-0.033', 'Mitotic cells (Skin)': '0.423', 'Parietal cells': '0.199', 'Chief cells': '-0.032', 'Gastric mucous cells': '0.292', 'Gastric enteroendocrine cells': '-0.037', 'Mitotic cells (Stomach)': '0.427', 'Parafollicular cells': '0.113', 'Thyroid glandular cells': '0.547', 'Mitotic cells (Thyroid)': '-0.029', 'Adrenal cortex cells': '0.598', 'Adrenal medulla cells': '0.036', 'Mitotic cells (Adrenal gland)': '0.454', 'Minor salivary glandular cells': '0.021', 'Minor salivary gland ductal cells': '-0.154', 'Minor salivary gland basal cells': '0.479', 'Mitotic cells (Minor salivary gland)': '0.567', 'Adipocytes (Minor salivary gland)': '0.168', 'Somatotropes': '-0.103', 'Lactotropes': '-0.055', 'Gonadotropes': '0.017', 'Corticotropes': '0.101', 'Thyrotropes': '0.252', 'Undifferentiated cells (Pituitary gland)': '0.231', 'Mitotic cells (Spleen)': '0.130', 'Platelets': '0.109', 'Erythrocytes': '-0.096', 'Hematopoietic stem cells': '0.138', 'B-cells (Spleen)': '0.099', 'NK-cells (Spleen)': '-0.049', 'Amygdala excitatory': '24.0', 'Cerebellar inhibitory': '56.9', 'Cge interneuron': '40.7', 'Deep-layer corticothalamic and 6b': '31.2', 'Deep-layer intratelencephalic': '26.5', 'Deep-layer near-projecting': '35.9', 'Eccentric medium spiny neuron': '29.7', 'Hippocampal ca1-3': '32.1', 'Hippocampal ca4': '44.6', 'Hippocampal dentate gyrus': '29.3', 'Lamp5-lhx6 and chandelier': '54.9', 'Lower rhombic lip': '42.4', 'Mammillary body': '39.9', 'Medium spiny neuron': '29.9', 'Mge interneuron': '41.8', 'Midbrain-derived inhibitory': '38.0', 'Miscellaneous': '32.8', 'Splatter': '41.1', 'Thalamic excitatory': '36.8', 'Upper rhombic lip': '48.8', 'Upper-layer intratelencephalic': '26.6', 'Astrocyte': '28.0', 'Bergmann glia': '43.4', 'Central nervous system macrophage': '33.2', 'Choroid plexus epithelial cell': '58.4', 'Committed oligodendrocyte precursor': '34.3', 'Ependymal cell': '37.1', 'Oligodendrocyte': '44.2', 'Oligodendrocyte precursor cell': '38.9', 'Endothelial cell': '37.8', 'Pericyte': '66.7', 'Vascular associated smooth muscle cell': '55.8', 'Fibroblast': '29.4', 'Leukocyte': '37.8', 'Basophil': '69.6', 'Eosinophil': '7.2', 'Neutrophil': '70.1', 'Classical monocyte': '127.1', 'Non-classical monocyte': '145.0', 'Intermediate monocyte': '143.7', 'T-reg': '94.3', 'GdT-cell': '15.0', 'MAIT T-cell': '105.9', 'Memory CD4 T-cell': '15.2', 'Naive CD4 T-cell': '80.2', 'Memory CD8 T-cell': '13.4', 'Naive CD8 T-cell': '72.6', 'Memory B-cell': '13.1', 'Naive B-cell': '55.7', 'Plasmacytoid DC': '179.7', 'Myeloid DC': '147.0', 'NK-cell': '103.1', 'Total PBMC': '147.5', 'Vd2 gdTCR': '94.4', 'Memory CD4 T-cell Th1\\/Th17': '88.5', 'Memory CD4 T-cell Th17': '96.3', 'Memory CD4 T-cell Th2': '87.4', 'Non-Vd2 gdTCR': '102.7', 'Memory CD4 T-cell Th1': '73.1', 'Memory CD4 T-cell TFH': '72.9', 'Terminal effector memory CD4 T-cell': '81.7', 'Central memory CD8 T-cell': '82.6', 'Effector memory CD8 T-cell': '97.5', 'Terminal effector memory CD8 T-cell': '138.1', 'Non-switched memory B-cell': '101.7', 'Plasmablast': '116.6', 'Switched memory B-cell': '94.3', 'Exhausted memory B-cell': '86.8', 'Progenitor cell': '94.5', 'Memory T-reg': '87.4', 'Naive CD4 T-cell activated': '130.5', 'Naive CD8 T-cell activated': '138.4', 'Naive T-reg': '74.1'}
8H9F, 8H9G, 8H9J, 8H9K, 8H9M, 8H9N, 8H9Q, 8H9R, 8H9S, 8H9T, 8H9U, 8H9V, 8KHF, 8KI3
{}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
82.896563
0.627852
2,538
O60260
P24864
12628165, 19946270, BioGrid E3Net
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
CCNE1
MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
Homo sapiens
Nucleus
Tissue enhanced (bone marrow, placenta)
{'Ciliated cells': '2.1', 'Basal respiratory cells': '0.1', 'Club cells': '0.8', 'Ionocytes': '0.0', 'Mucus glandular cells': '1.2', 'Serous glandular cells': '5.0', 'Gastric mucus-secreting cells': '2.9', 'Proximal enterocytes': '0.8', 'Paneth cells': '1.2', 'Distal enterocytes': '2.7', 'Intestinal goblet cells': '5.9', 'Exocrine glandular cells': '-0.191', 'Basal prostatic cells': '0.6', 'Prostatic glandular cells': '0.3', 'Breast glandular cells': '0.079', 'Breast myoepithelial cells': '-0.118', 'Glandular and luminal cells': '18.5', 'Secretory cells': '1.3', 'Basal keratinocytes': '3.9', 'Suprabasal keratinocytes': '6.6', 'Basal squamous epithelial cells': '4.4', 'Squamous epithelial cells': '8.6', 'Alveolar cells type 1': '-0.226', 'Alveolar cells type 2': '-0.038', 'Salivary duct cells': '1.1', 'Ductal cells': '0.186', 'Hepatocytes': '0.196', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.000', 'Distal tubular cells': '0.0', 'Collecting duct cells': '0.0', 'Mesothelial cells': '-0.160', 'Sertoli cells': '-0.159', 'Granulosa cells': '4.5', 'Enteroendocrine cells': '3.7', 'Pancreatic endocrine cells': '1.7', 'Leydig cells': '-0.261', 'Excitatory neurons': '2.8', 'Inhibitory neurons': '4.9', 'Cone photoreceptor cells': '1.7', 'Rod photoreceptor cells': '1.6', 'Bipolar cells': '2.2', 'Horizontal cells': '6.3', 'Astrocytes': '0.6', 'Oligodendrocyte precursor cells': '2.4', 'Oligodendrocytes': '1.3', 'Microglial cells': '0.0', 'Muller glia cells': '2.0', 'Schwann cells': '-0.041', 'Spermatogonia': '0.005', 'Spermatocytes': '0.442', 'Early spermatids': '0.503', 'Late spermatids': '0.156', 'Oocytes': '10.3', 'Cytotrophoblasts': '146.9', 'Syncytiotrophoblasts': '85.1', 'Extravillous trophoblasts': '2071.7', 'Endothelial cells': '0.9', 'Lymphatic endothelial cells': '0.2', 'Cardiomyocytes': '0.549', 'Skeletal myocytes': '-0.336', 'Smooth muscle cells': '3.0', 'Adipocytes': '2.7', 'Melanocytes': '0.133', 'Fibroblasts': '2.6', 'Peritubular cells': '-0.143', 'Endometrial stromal cells': '3.7', 'Ovarian stromal cells': '0.6', 'Undifferentiated cells': '10.7', 'T-cells': '3.4', 'B-cells': '2.6', 'Plasma cells': '16.0', 'Nk-cells': '0.7', 'Granulocytes': '0.7', 'Monocytes': '6.1', 'Macrophages': '4.1', 'Hofbauer cells': '17.8', 'Kupffer cells': '0.3', 'Dendritic cells': '0.8', 'Langerhans cells': '0.179', 'Erythroid cells': '-0.009', 'Adipocytes (Subcutaneous)': '0.210', 'Adipocytes (Visceral)': '0.208', 'Breast glandular cells (progenitors)': '0.014', 'Adipocytes (Breast)': '0.050', 'Colon enterocytes': '0.075', 'Colon enteroendocrine cells': '-0.075', 'Enteric glia cells': '-0.225', 'Mitotic cells (Colon)': '0.087', 'Mitotic cells (Heart)': '0.459', 'Podocytes': '-0.265', 'Ascending Loop of Henle cells': '0.401', 'Intercalated cells': '-0.152', 'Cholangiocyte': '0.368', 'NK-cells (Liver)': '-0.153', 'Respiratory ciliated cells': '0.008', 'Mitotic cells (Lung)': '0.543', 'NK-cells (Lung)': '0.031', 'B-cells (Lung)': '0.136', 'Alpha cells': '0.153', 'Beta cells': '0.121', 'Prostate glandular cells': '-0.198', 'Prostate basal glandular cells': '0.064', 'Urothelial cells': '0.035', 'Keratinocyte (other)': '0.238', 'Keratinocyte (granular)': '0.508', 'Hair cortex cells': '-0.217', 'Inner root sheath cells': '-0.195', 'Outer root sheath cells': '-0.287', 'Sebaceous gland cells': '-0.025', 'Eccrine sweat gland cells': '-0.357', 'Adipocytes (Skin)': '-0.214', 'Mitotic cells (Skin)': '-0.007', 'Parietal cells': '-0.243', 'Chief cells': '-0.309', 'Gastric mucous cells': '0.172', 'Gastric enteroendocrine cells': '-0.187', 'Mitotic cells (Stomach)': '0.476', 'Parafollicular cells': '0.031', 'Thyroid glandular cells': '0.242', 'Mitotic cells (Thyroid)': '0.008', 'Adrenal cortex cells': '0.210', 'Adrenal medulla cells': '-0.121', 'Mitotic cells (Adrenal gland)': '0.299', 'Minor salivary glandular cells': '0.217', 'Minor salivary gland ductal cells': '-0.211', 'Minor salivary gland basal cells': '0.648', 'Mitotic cells (Minor salivary gland)': '0.738', 'Adipocytes (Minor salivary gland)': '0.191', 'Somatotropes': '-0.203', 'Lactotropes': '-0.290', 'Gonadotropes': '-0.184', 'Corticotropes': '-0.056', 'Thyrotropes': '0.008', 'Undifferentiated cells (Pituitary gland)': '0.247', 'Mitotic cells (Spleen)': '0.761', 'Platelets': '0.137', 'Erythrocytes': '0.250', 'Hematopoietic stem cells': '0.248', 'B-cells (Spleen)': '-0.045', 'NK-cells (Spleen)': '-0.184', 'Amygdala excitatory': '3.2', 'Cerebellar inhibitory': '6.3', 'Cge interneuron': '8.4', 'Deep-layer corticothalamic and 6b': '3.9', 'Deep-layer intratelencephalic': '2.6', 'Deep-layer near-projecting': '4.0', 'Eccentric medium spiny neuron': '4.0', 'Hippocampal ca1-3': '4.4', 'Hippocampal ca4': '3.1', 'Hippocampal dentate gyrus': '4.7', 'Lamp5-lhx6 and chandelier': '5.7', 'Lower rhombic lip': '4.8', 'Mammillary body': '5.1', 'Medium spiny neuron': '4.8', 'Mge interneuron': '9.2', 'Midbrain-derived inhibitory': '7.4', 'Miscellaneous': '3.6', 'Splatter': '5.2', 'Thalamic excitatory': '6.0', 'Upper rhombic lip': '4.9', 'Upper-layer intratelencephalic': '2.8', 'Astrocyte': '2.7', 'Bergmann glia': '0.4', 'Central nervous system macrophage': '1.4', 'Choroid plexus epithelial cell': '0.5', 'Committed oligodendrocyte precursor': '3.0', 'Ependymal cell': '0.8', 'Oligodendrocyte': '1.7', 'Oligodendrocyte precursor cell': '2.7', 'Endothelial cell': '0.6', 'Pericyte': '1.1', 'Vascular associated smooth muscle cell': '0.5', 'Fibroblast': '1.1', 'Leukocyte': '1.8', 'Basophil': '0.0', 'Eosinophil': '0.0', 'Neutrophil': '0.4', 'Classical monocyte': '1.4', 'Non-classical monocyte': '22.1', 'Intermediate monocyte': '1.6', 'T-reg': '2.4', 'GdT-cell': '0.1', 'MAIT T-cell': '0.2', 'Memory CD4 T-cell': '0.1', 'Naive CD4 T-cell': '10.9', 'Memory CD8 T-cell': '0.0', 'Naive CD8 T-cell': '10.9', 'Memory B-cell': '0.6', 'Naive B-cell': '2.6', 'Plasmacytoid DC': '0.8', 'Myeloid DC': '0.4', 'NK-cell': '2.3', 'Total PBMC': '0.4', 'Vd2 gdTCR': '0.7', 'Memory CD4 T-cell Th1\\/Th17': '3.5', 'Memory CD4 T-cell Th17': '10.0', 'Memory CD4 T-cell Th2': '12.6', 'Non-Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1': '6.7', 'Memory CD4 T-cell TFH': '11.4', 'Terminal effector memory CD4 T-cell': '1.5', 'Central memory CD8 T-cell': '1.4', 'Effector memory CD8 T-cell': '0.1', 'Terminal effector memory CD8 T-cell': '0.6', 'Non-switched memory B-cell': '2.7', 'Plasmablast': '12.6', 'Switched memory B-cell': '2.9', 'Exhausted memory B-cell': '3.0', 'Progenitor cell': '0.9', 'Memory T-reg': '20.3', 'Naive CD4 T-cell activated': '4.2', 'Naive CD8 T-cell activated': '6.7', 'Naive T-reg': '13.8'}
1W98, 5L2W, 7KJS, 7XQK, 8H4R, 8H6P, 8H6T, 8VQ3, 8VQ4
{'Adipose Tissue': 1.399527242524917, 'Adrenal Gland': 8.372401937984497, 'Bladder': 3.9990238095238095, 'Blood': 6.10497487621098, 'Blood Vessel': 1.0825937078651686, 'Brain': 4.232462679788039, 'Breast': 1.310756448801743, 'Cervix Uteri': 1.7519052631578949, 'Colon': 4.156634017971759, 'Esophagus': 4.5748903114186845, 'Fallopian Tube': 1.487766666666667, 'Heart': 1.7322625783972128, 'Kidney': 1.1923685393258427, 'Liver': 0.5951428761061947, 'Lung': 2.3483027681660897, 'Muscle': 1.6197785678704857, 'Nerve': 4.278850888529887, 'Ovary': 1.5761694444444443, 'Pancreas': 0.8909765243902439, 'Pituitary': 2.0698681978798588, 'Prostate': 2.322377142857143, 'Salivary Gland': 2.538495061728395, 'Skin': 6.624410503040354, 'Small Intestine': 4.073737967914439, 'Spleen': 7.507618257261411, 'Stomach': 2.616608635097493, 'Testis': 28.481880886426595, 'Thyroid': 3.492701071975498, 'Uterus': 1.3871647887323943, 'Vagina': 3.5122333333333335}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
79.345439
0.44061
1,939
O60260
P24928
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
POLR2A
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN
Homo sapiens
Nucleus, Cytoplasm, Chromosome
Not found
{}
2GHQ, 2GHT, 2LTO, 3D9K, 3D9L, 3D9M, 3D9N, 3D9O, 3D9P, 4JXT, 5IY6, 5IY7, 5IY8, 5IY9, 5IYA, 5IYB, 5IYC, 5IYD, 5M3H, 5M3J, 6DRD, 6F5P, 6G0R, 6IC8, 6IC9, 6O9L, 6Q5Y, 6XKB, 6XRE, 7EGB, 7EGC, 7LBM, 7YCX, 7Z1K, 7Z42, 8PNQ, 8R3K, 8R3L, 8R60, 8R65
{'Adipose Tissue': 77.78716777408638, 'Adrenal Gland': 90.9481007751938, 'Bladder': 78.77571428571429, 'Blood': 65.17822497308934, 'Blood Vessel': 78.1478052434457, 'Brain': 48.11606813020439, 'Breast': 84.13681917211329, 'Cervix Uteri': 125.84842105263158, 'Colon': 51.8198973042362, 'Esophagus': 75.01076816608996, 'Fallopian Tube': 98.08333333333331, 'Heart': 27.163594657375143, 'Kidney': 43.35259550561798, 'Liver': 25.38924336283186, 'Lung': 80.23965397923875, 'Muscle': 42.78077210460772, 'Nerve': 107.99715670436188, 'Ovary': 105.96327777777778, 'Pancreas': 29.901740853658534, 'Pituitary': 101.51159010600706, 'Prostate': 74.05261224489796, 'Salivary Gland': 81.15882716049383, 'Skin': 117.04950801547815, 'Small Intestine': 77.3731550802139, 'Spleen': 84.70195020746887, 'Stomach': 52.70721448467967, 'Testis': 216.85739612188368, 'Thyroid': 106.25516079632465, 'Uterus': 116.68915492957748, 'Vagina': 115.0249358974359}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
75.637462
0.441589
106
O60260
P27338
33082525, 23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
MAOB
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
Homo sapiens
Mitochondrion outer membrane
Tissue enhanced (liver)
{'Ciliated cells': '21.8', 'Basal respiratory cells': '1.1', 'Club cells': '0.1', 'Ionocytes': '1.8', 'Mucus glandular cells': '1.9', 'Serous glandular cells': '34.4', 'Gastric mucus-secreting cells': '18.3', 'Proximal enterocytes': '179.7', 'Paneth cells': '10.4', 'Distal enterocytes': '6.7', 'Intestinal goblet cells': '3.5', 'Exocrine glandular cells': '-0.354', 'Basal prostatic cells': '0.4', 'Prostatic glandular cells': '0.0', 'Breast glandular cells': '0.121', 'Breast myoepithelial cells': '0.259', 'Glandular and luminal cells': '6.1', 'Secretory cells': '17.9', 'Basal keratinocytes': '4.6', 'Suprabasal keratinocytes': '2.4', 'Basal squamous epithelial cells': '2.7', 'Squamous epithelial cells': '2.1', 'Alveolar cells type 1': '0.187', 'Alveolar cells type 2': '-0.534', 'Salivary duct cells': '8.7', 'Ductal cells': '0.556', 'Hepatocytes': '0.743', 'Cholangiocytes': '51.5', 'Proximal tubular cells': '0.563', 'Distal tubular cells': '30.7', 'Collecting duct cells': '3.9', 'Mesothelial cells': '-0.052', 'Sertoli cells': '0.550', 'Granulosa cells': '54.9', 'Enteroendocrine cells': '5.6', 'Pancreatic endocrine cells': '8.5', 'Leydig cells': '0.682', 'Excitatory neurons': '35.7', 'Inhibitory neurons': '7.2', 'Cone photoreceptor cells': '1.7', 'Rod photoreceptor cells': '0.9', 'Bipolar cells': '2.3', 'Horizontal cells': '5.7', 'Astrocytes': '50.8', 'Oligodendrocyte precursor cells': '10.8', 'Oligodendrocytes': '1.2', 'Microglial cells': '8.9', 'Muller glia cells': '26.2', 'Schwann cells': '0.092', 'Spermatogonia': '0.472', 'Spermatocytes': '0.048', 'Early spermatids': '-0.557', 'Late spermatids': '-0.652', 'Oocytes': '1.5', 'Cytotrophoblasts': '0.2', 'Syncytiotrophoblasts': '0.4', 'Extravillous trophoblasts': '0.4', 'Endothelial cells': '10.9', 'Lymphatic endothelial cells': '7.4', 'Cardiomyocytes': '0.807', 'Skeletal myocytes': '0.404', 'Smooth muscle cells': '27.9', 'Adipocytes': '5.7', 'Melanocytes': '0.021', 'Fibroblasts': '13.6', 'Peritubular cells': '0.704', 'Endometrial stromal cells': '83.2', 'Ovarian stromal cells': '154.7', 'Undifferentiated cells': '10.5', 'T-cells': '3.1', 'B-cells': '1.1', 'Plasma cells': '1.8', 'Nk-cells': '0.0', 'Granulocytes': '213.3', 'Monocytes': '0.0', 'Macrophages': '1.7', 'Hofbauer cells': '1.2', 'Kupffer cells': '11.9', 'Dendritic cells': '0.0', 'Langerhans cells': '0.155', 'Erythroid cells': '-0.024', 'Adipocytes (Subcutaneous)': '0.637', 'Adipocytes (Visceral)': '0.680', 'Breast glandular cells (progenitors)': '-0.012', 'Adipocytes (Breast)': '0.114', 'Colon enterocytes': '-0.175', 'Colon enteroendocrine cells': '0.157', 'Enteric glia cells': '0.021', 'Mitotic cells (Colon)': '-0.134', 'Mitotic cells (Heart)': '0.326', 'Podocytes': '0.076', 'Ascending Loop of Henle cells': '0.265', 'Intercalated cells': '0.150', 'Cholangiocyte': '0.034', 'NK-cells (Liver)': '0.002', 'Respiratory ciliated cells': '0.102', 'Mitotic cells (Lung)': '-0.175', 'NK-cells (Lung)': '0.408', 'B-cells (Lung)': '0.166', 'Alpha cells': '0.449', 'Beta cells': '0.256', 'Prostate glandular cells': '-0.273', 'Prostate basal glandular cells': '-0.180', 'Urothelial cells': '-0.253', 'Keratinocyte (other)': '-0.232', 'Keratinocyte (granular)': '-0.305', 'Hair cortex cells': '0.219', 'Inner root sheath cells': '0.193', 'Outer root sheath cells': '0.381', 'Sebaceous gland cells': '0.162', 'Eccrine sweat gland cells': '0.473', 'Adipocytes (Skin)': '0.428', 'Mitotic cells (Skin)': '0.133', 'Parietal cells': '-0.561', 'Chief cells': '-0.532', 'Gastric mucous cells': '-0.595', 'Gastric enteroendocrine cells': '-0.268', 'Mitotic cells (Stomach)': '-0.241', 'Parafollicular cells': '-0.017', 'Thyroid glandular cells': '0.208', 'Mitotic cells (Thyroid)': '0.224', 'Adrenal cortex cells': '0.651', 'Adrenal medulla cells': '0.028', 'Mitotic cells (Adrenal gland)': '0.282', 'Minor salivary glandular cells': '0.075', 'Minor salivary gland ductal cells': '0.081', 'Minor salivary gland basal cells': '0.599', 'Mitotic cells (Minor salivary gland)': '0.486', 'Adipocytes (Minor salivary gland)': '0.314', 'Somatotropes': '-0.043', 'Lactotropes': '0.552', 'Gonadotropes': '0.465', 'Corticotropes': '0.087', 'Thyrotropes': '0.469', 'Undifferentiated cells (Pituitary gland)': '0.052', 'Mitotic cells (Spleen)': '-0.110', 'Platelets': '0.063', 'Erythrocytes': '-0.059', 'Hematopoietic stem cells': '0.061', 'B-cells (Spleen)': '0.055', 'NK-cells (Spleen)': '-0.065', 'Amygdala excitatory': '68.8', 'Cerebellar inhibitory': '1.8', 'Cge interneuron': '33.8', 'Deep-layer corticothalamic and 6b': '100.4', 'Deep-layer intratelencephalic': '65.3', 'Deep-layer near-projecting': '57.8', 'Eccentric medium spiny neuron': '120.0', 'Hippocampal ca1-3': '105.7', 'Hippocampal ca4': '52.9', 'Hippocampal dentate gyrus': '153.6', 'Lamp5-lhx6 and chandelier': '16.2', 'Lower rhombic lip': '56.3', 'Mammillary body': '91.0', 'Medium spiny neuron': '113.0', 'Mge interneuron': '15.7', 'Midbrain-derived inhibitory': '2.6', 'Miscellaneous': '55.6', 'Splatter': '67.8', 'Thalamic excitatory': '68.9', 'Upper rhombic lip': '15.3', 'Upper-layer intratelencephalic': '76.9', 'Astrocyte': '193.1', 'Bergmann glia': '16.1', 'Central nervous system macrophage': '2.9', 'Choroid plexus epithelial cell': '70.7', 'Committed oligodendrocyte precursor': '17.0', 'Ependymal cell': '315.8', 'Oligodendrocyte': '2.2', 'Oligodendrocyte precursor cell': '38.0', 'Endothelial cell': '17.0', 'Pericyte': '2.1', 'Vascular associated smooth muscle cell': '6.4', 'Fibroblast': '26.2', 'Leukocyte': '3.8', 'Basophil': '0.0', 'Eosinophil': '0.0', 'Neutrophil': '0.0', 'Classical monocyte': '0.0', 'Non-classical monocyte': '0.0', 'Intermediate monocyte': '0.0', 'T-reg': '0.5', 'GdT-cell': '0.0', 'MAIT T-cell': '0.0', 'Memory CD4 T-cell': '0.0', 'Naive CD4 T-cell': '0.0', 'Memory CD8 T-cell': '0.0', 'Naive CD8 T-cell': '0.1', 'Memory B-cell': '0.0', 'Naive B-cell': '0.0', 'Plasmacytoid DC': '0.0', 'Myeloid DC': '0.0', 'NK-cell': '0.0', 'Total PBMC': '0.4', 'Vd2 gdTCR': '0.0', 'Memory CD4 T-cell Th1\\/Th17': '0.0', 'Memory CD4 T-cell Th17': '0.0', 'Memory CD4 T-cell Th2': '0.0', 'Non-Vd2 gdTCR': '0.4', 'Memory CD4 T-cell Th1': '0.0', 'Memory CD4 T-cell TFH': '0.0', 'Terminal effector memory CD4 T-cell': '0.0', 'Central memory CD8 T-cell': '0.0', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '0.0', 'Non-switched memory B-cell': '0.0', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.0', 'Exhausted memory B-cell': '0.0', 'Progenitor cell': '1.5', 'Memory T-reg': '0.1', 'Naive CD4 T-cell activated': '0.0', 'Naive CD8 T-cell activated': '0.0', 'Naive T-reg': '0.4'}
1GOS, 1OJ9, 1OJA, 1OJC, 1OJD, 1S2Q, 1S2Y, 1S3B, 1S3E, 2BK3, 2BK4, 2BK5, 2BYB, 2C64, 2C65, 2C66, 2C67, 2C70, 2C72, 2C73, 2C75, 2C76, 2V5Z, 2V60, 2V61, 2VRL, 2VRM, 2VZ2, 2XCG, 2XFN, 2XFO, 2XFP, 2XFQ, 2XFU, 3PO7, 3ZYX, 4A79, 4A7A, 4CRT, 5MRL, 6FVZ, 6FW0, 6FWC, 6RKB, 6RKP, 6RLE, 6YT2, 7B0V, 7B0Z, 7P4F, 7P4H, 7ZW3
{'Adipose Tissue': 74.01206976744187, 'Adrenal Gland': 64.48266279069767, 'Bladder': 51.27985714285714, 'Blood': 0.6246943487621098, 'Blood Vessel': 130.844531835206, 'Brain': 73.56233762301287, 'Breast': 78.07946187363834, 'Cervix Uteri': 62.81894736842105, 'Colon': 58.93475353016689, 'Esophagus': 65.94564775086505, 'Fallopian Tube': 175.12444444444444, 'Heart': 44.40159605110337, 'Kidney': 42.80875280898877, 'Liver': 103.0282168141593, 'Lung': 66.34917474048443, 'Muscle': 60.76687795765878, 'Nerve': 49.89639741518578, 'Ovary': 245.38677777777775, 'Pancreas': 5.238100609756097, 'Pituitary': 47.44128268551237, 'Prostate': 80.9309469387755, 'Salivary Gland': 30.194277777777778, 'Skin': 11.32986484798231, 'Small Intestine': 73.92404278074866, 'Spleen': 3.0469842323651455, 'Stomach': 32.08146796657381, 'Testis': 14.734562326869804, 'Thyroid': 12.269402603369066, 'Uterus': 250.39387323943663, 'Vagina': 51.3395}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
95.628058
0.266481
1,508
O60260
P31949
33082525
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
S100A11
MAKISSPTETERCIESLIAVFQKYAGKDGYNYTLSKTEFLSFMNTELAAFTKNQKDPGVLDRMMKKLDTNSDGQLDFSEFLNLIGGLAMACHDSFLKAVPSQKRT
Homo sapiens
Cytoplasm, Nucleus
Tissue enhanced (esophagus)
{'Ciliated cells': '2404.7', 'Basal respiratory cells': '5108.4', 'Club cells': '2793.2', 'Ionocytes': '2949.2', 'Mucus glandular cells': '1275.0', 'Serous glandular cells': '1475.0', 'Gastric mucus-secreting cells': '631.4', 'Proximal enterocytes': '369.8', 'Paneth cells': '672.1', 'Distal enterocytes': '380.2', 'Intestinal goblet cells': '320.4', 'Exocrine glandular cells': '-0.756', 'Basal prostatic cells': '1681.3', 'Prostatic glandular cells': '470.8', 'Breast glandular cells': '-0.093', 'Breast myoepithelial cells': '0.022', 'Glandular and luminal cells': '1630.1', 'Secretory cells': '1597.2', 'Basal keratinocytes': '2818.3', 'Suprabasal keratinocytes': '6422.6', 'Basal squamous epithelial cells': '1502.7', 'Squamous epithelial cells': '4671.6', 'Alveolar cells type 1': '-0.212', 'Alveolar cells type 2': '0.095', 'Salivary duct cells': '1312.8', 'Ductal cells': '0.780', 'Hepatocytes': '0.243', 'Cholangiocytes': '555.2', 'Proximal tubular cells': '0.144', 'Distal tubular cells': '1355.4', 'Collecting duct cells': '2221.0', 'Mesothelial cells': '-0.093', 'Sertoli cells': '0.371', 'Granulosa cells': '66.4', 'Enteroendocrine cells': '511.0', 'Pancreatic endocrine cells': '4842.6', 'Leydig cells': '0.469', 'Excitatory neurons': '0.0', 'Inhibitory neurons': '0.0', 'Cone photoreceptor cells': '0.0', 'Rod photoreceptor cells': '0.6', 'Bipolar cells': '0.2', 'Horizontal cells': '0.6', 'Astrocytes': '1.2', 'Oligodendrocyte precursor cells': '0.0', 'Oligodendrocytes': '0.0', 'Microglial cells': '15.2', 'Muller glia cells': '29.2', 'Schwann cells': '0.109', 'Spermatogonia': '0.230', 'Spermatocytes': '-0.180', 'Early spermatids': '-0.387', 'Late spermatids': '-0.264', 'Oocytes': '12.5', 'Cytotrophoblasts': '3326.3', 'Syncytiotrophoblasts': '3831.6', 'Extravillous trophoblasts': '6895.5', 'Endothelial cells': '641.2', 'Lymphatic endothelial cells': '363.8', 'Cardiomyocytes': '-0.010', 'Skeletal myocytes': '0.053', 'Smooth muscle cells': '608.8', 'Adipocytes': '625.5', 'Melanocytes': '0.150', 'Fibroblasts': '963.5', 'Peritubular cells': '0.305', 'Endometrial stromal cells': '568.7', 'Ovarian stromal cells': '226.5', 'Undifferentiated cells': '314.1', 'T-cells': '443.8', 'B-cells': '184.6', 'Plasma cells': '171.7', 'Nk-cells': '325.7', 'Granulocytes': '1002.7', 'Monocytes': '3326.8', 'Macrophages': '2132.2', 'Hofbauer cells': '3942.7', 'Kupffer cells': '1080.1', 'Dendritic cells': '275.0', 'Langerhans cells': '0.094', 'Erythroid cells': '0.058', 'Adipocytes (Subcutaneous)': '-0.062', 'Adipocytes (Visceral)': '0.075', 'Breast glandular cells (progenitors)': '-0.178', 'Adipocytes (Breast)': '0.034', 'Colon enterocytes': '-0.192', 'Colon enteroendocrine cells': '0.063', 'Enteric glia cells': '0.305', 'Mitotic cells (Colon)': '0.143', 'Mitotic cells (Heart)': '0.454', 'Podocytes': '-0.009', 'Ascending Loop of Henle cells': '0.159', 'Intercalated cells': '-0.167', 'Cholangiocyte': '0.532', 'NK-cells (Liver)': '-0.251', 'Respiratory ciliated cells': '0.035', 'Mitotic cells (Lung)': '0.318', 'NK-cells (Lung)': '-0.131', 'B-cells (Lung)': '-0.156', 'Alpha cells': '0.331', 'Beta cells': '0.206', 'Prostate glandular cells': '-0.006', 'Prostate basal glandular cells': '0.431', 'Urothelial cells': '0.505', 'Keratinocyte (other)': '0.365', 'Keratinocyte (granular)': '-0.121', 'Hair cortex cells': '0.039', 'Inner root sheath cells': '0.049', 'Outer root sheath cells': '0.073', 'Sebaceous gland cells': '-0.106', 'Eccrine sweat gland cells': '-0.152', 'Adipocytes (Skin)': '-0.264', 'Mitotic cells (Skin)': '0.256', 'Parietal cells': '-0.358', 'Chief cells': '-0.285', 'Gastric mucous cells': '0.202', 'Gastric enteroendocrine cells': '-0.101', 'Mitotic cells (Stomach)': '0.514', 'Parafollicular cells': '-0.021', 'Thyroid glandular cells': '-0.034', 'Mitotic cells (Thyroid)': '0.181', 'Adrenal cortex cells': '0.122', 'Adrenal medulla cells': '0.061', 'Mitotic cells (Adrenal gland)': '0.341', 'Minor salivary glandular cells': '0.293', 'Minor salivary gland ductal cells': '-0.289', 'Minor salivary gland basal cells': '0.744', 'Mitotic cells (Minor salivary gland)': '0.780', 'Adipocytes (Minor salivary gland)': '0.179', 'Somatotropes': '-0.149', 'Lactotropes': '-0.306', 'Gonadotropes': '-0.164', 'Corticotropes': '-0.133', 'Thyrotropes': '-0.006', 'Undifferentiated cells (Pituitary gland)': '0.263', 'Mitotic cells (Spleen)': '-0.105', 'Platelets': '0.101', 'Erythrocytes': '0.037', 'Hematopoietic stem cells': '0.197', 'B-cells (Spleen)': '-0.296', 'NK-cells (Spleen)': '0.017', 'Amygdala excitatory': '0.2', 'Cerebellar inhibitory': '0.9', 'Cge interneuron': '0.3', 'Deep-layer corticothalamic and 6b': '0.1', 'Deep-layer intratelencephalic': '0.1', 'Deep-layer near-projecting': '0.2', 'Eccentric medium spiny neuron': '0.1', 'Hippocampal ca1-3': '0.0', 'Hippocampal ca4': '0.4', 'Hippocampal dentate gyrus': '0.1', 'Lamp5-lhx6 and chandelier': '0.1', 'Lower rhombic lip': '0.6', 'Mammillary body': '0.1', 'Medium spiny neuron': '0.1', 'Mge interneuron': '0.2', 'Midbrain-derived inhibitory': '0.1', 'Miscellaneous': '0.1', 'Splatter': '0.3', 'Thalamic excitatory': '0.1', 'Upper rhombic lip': '0.6', 'Upper-layer intratelencephalic': '0.2', 'Astrocyte': '1.4', 'Bergmann glia': '3.0', 'Central nervous system macrophage': '104.7', 'Choroid plexus epithelial cell': '17.8', 'Committed oligodendrocyte precursor': '3.7', 'Ependymal cell': '19.5', 'Oligodendrocyte': '0.7', 'Oligodendrocyte precursor cell': '0.5', 'Endothelial cell': '87.2', 'Pericyte': '115.3', 'Vascular associated smooth muscle cell': '138.2', 'Fibroblast': '80.9', 'Leukocyte': '98.4', 'Basophil': '668.0', 'Eosinophil': '7236.5', 'Neutrophil': '4549.3', 'Classical monocyte': '1704.7', 'Non-classical monocyte': '1998.1', 'Intermediate monocyte': '924.2', 'T-reg': '86.6', 'GdT-cell': '715.7', 'MAIT T-cell': '77.1', 'Memory CD4 T-cell': '1350.9', 'Naive CD4 T-cell': '33.1', 'Memory CD8 T-cell': '845.5', 'Naive CD8 T-cell': '17.0', 'Memory B-cell': '356.6', 'Naive B-cell': '2.9', 'Plasmacytoid DC': '141.6', 'Myeloid DC': '472.3', 'NK-cell': '176.4', 'Total PBMC': '463.6', 'Vd2 gdTCR': '117.4', 'Memory CD4 T-cell Th1\\/Th17': '167.6', 'Memory CD4 T-cell Th17': '231.3', 'Memory CD4 T-cell Th2': '170.1', 'Non-Vd2 gdTCR': '67.2', 'Memory CD4 T-cell Th1': '151.6', 'Memory CD4 T-cell TFH': '199.2', 'Terminal effector memory CD4 T-cell': '102.8', 'Central memory CD8 T-cell': '76.4', 'Effector memory CD8 T-cell': '70.9', 'Terminal effector memory CD8 T-cell': '106.5', 'Non-switched memory B-cell': '51.1', 'Plasmablast': '43.2', 'Switched memory B-cell': '53.9', 'Exhausted memory B-cell': '95.7', 'Progenitor cell': '31.9', 'Memory T-reg': '287.0', 'Naive CD4 T-cell activated': '160.7', 'Naive CD8 T-cell activated': '165.1', 'Naive T-reg': '54.4'}
1V4Z, 1V50, 2LUC
{'Adipose Tissue': 745.940365448505, 'Adrenal Gland': 207.0258527131783, 'Bladder': 1056.9095238095238, 'Blood': 3699.550581270183, 'Blood Vessel': 903.419850187266, 'Brain': 44.59161998485995, 'Breast': 691.0891067538126, 'Cervix Uteri': 957.3052631578948, 'Colon': 323.2188061617458, 'Esophagus': 1936.9192802768168, 'Fallopian Tube': 573.8777777777777, 'Heart': 176.2000348432056, 'Kidney': 544.4224719101123, 'Liver': 58.155309734513274, 'Lung': 1070.1835640138409, 'Muscle': 51.11340224159402, 'Nerve': 581.7048465266558, 'Ovary': 219.01677777777775, 'Pancreas': 133.62420731707317, 'Pituitary': 279.35173144876325, 'Prostate': 716.7020408163265, 'Salivary Gland': 1312.735802469136, 'Skin': 1109.6910447761195, 'Small Intestine': 272.43085561497327, 'Spleen': 813.8, 'Stomach': 422.6875487465181, 'Testis': 149.68531855955678, 'Thyroid': 486.7378254211332, 'Uterus': 440.8401408450704, 'Vagina': 2189.726282051282}
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[51.2, 65.76, 65.56, 76.14, 85.04, 90.05, 92.03, 96.43, 96.4, 96.44, 96.16, 96.9, 96.63, 96.61, 95.68, 96.53, 96.43, 95.69, 94.82, 95.71, 95.77, 93.45, 93.78, 95.22, 93.7, 81.42, 79.1, 75.32, 73.69, 74.69, 76.88, 89.21, 95.43, 96.34, 94.87, 93.53, 93.84, 95.65, 95.91, 94.17, 94.79, 96.17, 95.6, 93.73, 95.12, 95.02, 92.84, 92.44, 89.92, 87.14, 87.43, 88.53, 89.65, 86.28, 87.22, 90.77, 82.75, 91.28, 93.04, 93.63, 93.95, 94.44, 94.55, 95.04, 95.7, 96.2, 96.63, 97.21, 96.19, 96.26, 94.71, 94.76, 93.76, 94.82, 96.76, 96.47, 96.03, 96.96, 97.7, 96.91, 97.46, 96.72, 95.69, 96.3, 96.32, 95.23, 92.59, 95.07, 95.8, 92.57, 90.81, 93.18, 95.24, 92.25, 90.26, 92.02, 90.86, 85.37, 75.21, 63.35, 62.7, 57.85, 49.22, 52.96, 47.84]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
89.423333
0.476
2,980
O60260
P32189
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
GK
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIYGLMKISHSVKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP
Homo sapiens
Mitochondrion outer membrane, Nucleus, Cytoplasm, cytosol, Mitochondrion outer membrane, Nucleus, Cytoplasm, cytosol
Tissue enhanced (intestine, kidney, liver)
{'Ciliated cells': '24.8', 'Basal respiratory cells': '15.8', 'Club cells': '16.7', 'Ionocytes': '20.6', 'Mucus glandular cells': '21.7', 'Serous glandular cells': '13.7', 'Gastric mucus-secreting cells': '14.7', 'Proximal enterocytes': '138.9', 'Paneth cells': '19.0', 'Distal enterocytes': '31.5', 'Intestinal goblet cells': '13.3', 'Exocrine glandular cells': '-0.510', 'Basal prostatic cells': '3.9', 'Prostatic glandular cells': '5.0', 'Breast glandular cells': '0.477', 'Breast myoepithelial cells': '0.428', 'Glandular and luminal cells': '1.4', 'Secretory cells': '2.9', 'Basal keratinocytes': '8.0', 'Suprabasal keratinocytes': '11.8', 'Basal squamous epithelial cells': '7.1', 'Squamous epithelial cells': '14.6', 'Alveolar cells type 1': '-0.115', 'Alveolar cells type 2': '0.150', 'Salivary duct cells': '8.0', 'Ductal cells': '0.625', 'Hepatocytes': '0.225', 'Cholangiocytes': '15.3', 'Proximal tubular cells': '0.762', 'Distal tubular cells': '15.4', 'Collecting duct cells': '9.7', 'Mesothelial cells': '-0.094', 'Sertoli cells': '-0.421', 'Granulosa cells': '4.9', 'Enteroendocrine cells': '15.9', 'Pancreatic endocrine cells': '10.2', 'Leydig cells': '-0.337', 'Excitatory neurons': '40.1', 'Inhibitory neurons': '35.7', 'Cone photoreceptor cells': '11.9', 'Rod photoreceptor cells': '15.3', 'Bipolar cells': '5.8', 'Horizontal cells': '1.9', 'Astrocytes': '18.6', 'Oligodendrocyte precursor cells': '26.9', 'Oligodendrocytes': '18.2', 'Microglial cells': '9.8', 'Muller glia cells': '25.0', 'Schwann cells': '-0.040', 'Spermatogonia': '-0.122', 'Spermatocytes': '0.262', 'Early spermatids': '0.626', 'Late spermatids': '0.503', 'Oocytes': '1.5', 'Cytotrophoblasts': '1.1', 'Syncytiotrophoblasts': '1.0', 'Extravillous trophoblasts': '0.9', 'Endothelial cells': '3.1', 'Lymphatic endothelial cells': '2.1', 'Cardiomyocytes': '0.587', 'Skeletal myocytes': '0.345', 'Smooth muscle cells': '4.0', 'Adipocytes': '1.7', 'Melanocytes': '0.187', 'Fibroblasts': '4.7', 'Peritubular cells': '-0.221', 'Endometrial stromal cells': '2.3', 'Ovarian stromal cells': '4.4', 'Undifferentiated cells': '8.4', 'T-cells': '10.7', 'B-cells': '14.1', 'Plasma cells': '9.2', 'Nk-cells': '4.5', 'Granulocytes': '21.3', 'Monocytes': '392.2', 'Macrophages': '115.5', 'Hofbauer cells': '46.1', 'Kupffer cells': '21.6', 'Dendritic cells': '7.1', 'Langerhans cells': '0.384', 'Erythroid cells': '-0.086', 'Adipocytes (Subcutaneous)': '-0.209', 'Adipocytes (Visceral)': '-0.043', 'Breast glandular cells (progenitors)': '0.217', 'Adipocytes (Breast)': '-0.599', 'Colon enterocytes': '0.183', 'Colon enteroendocrine cells': '0.061', 'Enteric glia cells': '-0.104', 'Mitotic cells (Colon)': '0.254', 'Mitotic cells (Heart)': '0.441', 'Podocytes': '0.235', 'Ascending Loop of Henle cells': '-0.082', 'Intercalated cells': '0.264', 'Cholangiocyte': '0.254', 'NK-cells (Liver)': '-0.242', 'Respiratory ciliated cells': '-0.035', 'Mitotic cells (Lung)': '0.140', 'NK-cells (Lung)': '0.144', 'B-cells (Lung)': '0.099', 'Alpha cells': '0.313', 'Beta cells': '0.201', 'Prostate glandular cells': '-0.111', 'Prostate basal glandular cells': '0.172', 'Urothelial cells': '0.219', 'Keratinocyte (other)': '0.236', 'Keratinocyte (granular)': '0.010', 'Hair cortex cells': '-0.148', 'Inner root sheath cells': '-0.154', 'Outer root sheath cells': '0.080', 'Sebaceous gland cells': '0.424', 'Eccrine sweat gland cells': '-0.128', 'Adipocytes (Skin)': '-0.105', 'Mitotic cells (Skin)': '0.357', 'Parietal cells': '-0.369', 'Chief cells': '-0.418', 'Gastric mucous cells': '-0.015', 'Gastric enteroendocrine cells': '-0.248', 'Mitotic cells (Stomach)': '0.257', 'Parafollicular cells': '0.160', 'Thyroid glandular cells': '0.350', 'Mitotic cells (Thyroid)': '0.140', 'Adrenal cortex cells': '0.613', 'Adrenal medulla cells': '-0.062', 'Mitotic cells (Adrenal gland)': '-0.074', 'Minor salivary glandular cells': '0.501', 'Minor salivary gland ductal cells': '0.201', 'Minor salivary gland basal cells': '-0.251', 'Mitotic cells (Minor salivary gland)': '-0.289', 'Adipocytes (Minor salivary gland)': '-0.327', 'Somatotropes': '0.195', 'Lactotropes': '0.178', 'Gonadotropes': '0.163', 'Corticotropes': '-0.229', 'Thyrotropes': '-0.048', 'Undifferentiated cells (Pituitary gland)': '-0.029', 'Mitotic cells (Spleen)': '0.026', 'Platelets': '0.259', 'Erythrocytes': '-0.057', 'Hematopoietic stem cells': '0.095', 'B-cells (Spleen)': '0.025', 'NK-cells (Spleen)': '0.042', 'Amygdala excitatory': '23.1', 'Cerebellar inhibitory': '52.6', 'Cge interneuron': '26.8', 'Deep-layer corticothalamic and 6b': '24.2', 'Deep-layer intratelencephalic': '26.2', 'Deep-layer near-projecting': '30.7', 'Eccentric medium spiny neuron': '29.3', 'Hippocampal ca1-3': '36.8', 'Hippocampal ca4': '32.9', 'Hippocampal dentate gyrus': '15.4', 'Lamp5-lhx6 and chandelier': '28.8', 'Lower rhombic lip': '41.3', 'Mammillary body': '54.0', 'Medium spiny neuron': '26.3', 'Mge interneuron': '33.9', 'Midbrain-derived inhibitory': '31.3', 'Miscellaneous': '26.1', 'Splatter': '34.4', 'Thalamic excitatory': '41.6', 'Upper rhombic lip': '29.2', 'Upper-layer intratelencephalic': '25.8', 'Astrocyte': '31.4', 'Bergmann glia': '33.2', 'Central nervous system macrophage': '41.1', 'Choroid plexus epithelial cell': '36.7', 'Committed oligodendrocyte precursor': '21.3', 'Ependymal cell': '52.4', 'Oligodendrocyte': '27.4', 'Oligodendrocyte precursor cell': '32.9', 'Endothelial cell': '7.2', 'Pericyte': '16.3', 'Vascular associated smooth muscle cell': '11.5', 'Fibroblast': '20.3', 'Leukocyte': '55.4', 'Basophil': '29.6', 'Eosinophil': '7.2', 'Neutrophil': '738.5', 'Classical monocyte': '16.3', 'Non-classical monocyte': '9.8', 'Intermediate monocyte': '31.7', 'T-reg': '15.2', 'GdT-cell': '1.7', 'MAIT T-cell': '4.3', 'Memory CD4 T-cell': '3.0', 'Naive CD4 T-cell': '3.6', 'Memory CD8 T-cell': '2.1', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '2.9', 'Naive B-cell': '11.0', 'Plasmacytoid DC': '11.2', 'Myeloid DC': '52.9', 'NK-cell': '3.2', 'Total PBMC': '32.6', 'Vd2 gdTCR': '5.5', 'Memory CD4 T-cell Th1\\/Th17': '3.6', 'Memory CD4 T-cell Th17': '3.9', 'Memory CD4 T-cell Th2': '4.8', 'Non-Vd2 gdTCR': '8.9', 'Memory CD4 T-cell Th1': '3.2', 'Memory CD4 T-cell TFH': '3.6', 'Terminal effector memory CD4 T-cell': '8.0', 'Central memory CD8 T-cell': '6.1', 'Effector memory CD8 T-cell': '8.9', 'Terminal effector memory CD8 T-cell': '4.8', 'Non-switched memory B-cell': '16.7', 'Plasmablast': '13.0', 'Switched memory B-cell': '10.7', 'Exhausted memory B-cell': '18.7', 'Progenitor cell': '20.5', 'Memory T-reg': '9.0', 'Naive CD4 T-cell activated': '26.3', 'Naive CD8 T-cell activated': '5.8', 'Naive T-reg': '7.0'}
null
{'Adipose Tissue': 2.9668999169435217, 'Adrenal Gland': 6.069182170542636, 'Bladder': 2.88152380952381, 'Blood': 28.077578040904196, 'Blood Vessel': 3.2800273408239704, 'Brain': 2.442224905374716, 'Breast': 2.5281444444444445, 'Cervix Uteri': 2.4315263157894735, 'Colon': 3.268350962772786, 'Esophagus': 3.235918339100346, 'Fallopian Tube': 4.590777777777777, 'Heart': 1.9063397444831591, 'Kidney': 9.3729202247191, 'Liver': 20.74442477876106, 'Lung': 17.468671280276816, 'Muscle': 0.9070352552926524, 'Nerve': 4.384954765751211, 'Ovary': 3.1586555555555553, 'Pancreas': 0.9995600609756098, 'Pituitary': 6.051696113074206, 'Prostate': 2.786025714285714, 'Salivary Gland': 7.504037037037037, 'Skin': 6.1314943062465455, 'Small Intestine': 10.477860962566844, 'Spleen': 8.241116182572613, 'Stomach': 2.0785103064066854, 'Testis': 4.09887811634349, 'Thyroid': 3.481977029096478, 'Uterus': 3.153507042253521, 'Vagina': 2.611797435897436}
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[0.99, 0.94, 0.86, 0.72, 0.93, 0.56, 0.64, 0.84, 0.28, 0.42, 0.26, 0.0, 0.0, 0.0, 0.0, 0.01, 0.04, 0.0, 0.3, 0.1, 0.31, 0.16, 0.0, 0.2, 0.0, 0.01, 0.0, 0.0, 0.1, 0.07, 0.67, 0.5, 0.19, 0.54, 0.23, 0.15, 0.09, 0.51, 0.21, 0.56, 0.19, 0.84, 0.09, 0.61, 0.23, 0.33, 0.64, 0.56, 0.7, 0.9, 0.29, 0.17, 0.09, 0.04, 0.0, 0.36, 0.01, 0.43, 0.32, 0.0, 0.15, 0.63, 0.03, 0.0, 0.34, 0.36, 0.0, 0.02, 0.34, 0.39, 0.0, 0.03, 0.4, 0.35, 0.0, 0.49, 0.65, 0.56, 0.57, 0.14, 0.34, 0.17, 0.49, 0.24, 0.02, 0.45, 0.0, 0.01, 0.0, 0.0, 0.0, 0.0, 0.01, 0.02, 0.02, 0.0, 0.0, 0.0, 0.02, 0.0, 0.07, 0.45, 0.69, 0.56, 0.2, 0.48, 0.24, 0.12, 0.3, 0.32, 0.0, 0.0, 0.0, 0.04, 0.12, 0.0, 0.18, 0.07, 0.0, 0.32, 0.61, 0.14, 0.1, 0.42, 0.42, 0.04, 0.44, 0.83, 0.63, 0.24, 0.56, 0.88, 0.55, 0.8, 0.52, 0.17, 0.06, 0.27, 0.43, 0.16, 0.0, 0.01, 0.0, 0.3, 0.22, 0.13, 0.07, 0.01, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.2, 0.12, 0.0, 0.1, 0.66, 0.62, 0.09, 0.81, 0.67, 0.01, 0.44, 0.55, 0.0, 0.22, 0.64, 0.49, 0.74, 0.22, 0.03, 0.09, 0.01, 0.0, 0.03, 0.0, 0.0, 0.0, 0.02, 0.0, 0.0, 0.05, 0.12, 0.02, 0.04, 0.21, 0.12, 0.49, 0.74, 0.66, 0.21, 0.23, 0.14, 0.01, 0.01, 0.0, 0.04, 0.0, 0.0, 0.01, 0.01, 0.0, 0.02, 0.0, 0.0, 0.0, 0.14, 0.0, 0.54, 0.57, 0.22, 0.64, 0.17, 0.13, 0.62, 0.54, 0.0, 0.02, 0.62, 0.18, 0.01, 0.44, 0.06, 0.28, 0.41, 0.85, 0.05, 0.09, 0.02, 0.62, 0.29, 0.29, 0.05, 0.0, 0.03, 0.24, 0.38, 0.03, 0.15, 0.54, 0.02, 0.44, 0.2, 0.84, 0.95, 0.76, 0.42, 0.73, 0.03, 0.5, 0.45, 0.0, 0.48, 0.48, 0.09, 0.16, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.19, 0.04, 0.0, 0.0, 0.0, 0.0, 0.0, 0.09, 0.1, 0.22, 0.01, 0.19, 0.65, 0.72, 0.41, 0.31, 0.05, 0.0, 0.0, 0.1, 0.0, 0.34, 0.12, 0.03, 0.02, 0.07, 0.02, 0.0, 0.03, 0.01, 0.1, 0.06, 0.52, 0.76, 0.26, 0.29, 0.39, 0.01, 0.88, 0.32, 0.21, 0.03, 0.0, 0.0, 0.0, 0.0, 0.0, 0.02, 0.12, 0.18, 0.12, 0.76, 0.95, 0.66, 0.54, 0.16, 0.28, 0.04, 0.01, 0.0, 0.0, 0.0, 0.0, 0.03, 0.04, 0.05, 0.0, 0.09, 0.15, 0.01, 0.06, 0.24, 0.28, 0.0, 0.36, 0.84, 0.7, 0.49, 0.64, 0.15, 0.03, 0.85, 0.51, 0.39, 0.69, 0.27, 0.01, 0.29, 0.68, 0.06, 0.01, 0.75, 0.69, 0.2, 0.57, 0.36, 0.05, 0.54, 0.4, 0.01, 0.11, 0.01, 0.0, 0.01, 0.0, 0.29, 0.16, 0.05, 0.08, 0.06, 0.09, 0.24, 0.29, 0.22, 0.31, 0.4, 0.17, 0.0, 0.24, 0.47, 0.13, 0.34, 0.32, 0.48, 0.59, 0.58, 0.97, 0.6, 0.25, 0.46, 0.51, 0.08, 0.01, 0.16, 0.0, 0.05, 0.02, 0.0, 0.0, 0.03, 0.01, 0.0, 0.0, 0.01, 0.08, 0.02, 0.07, 0.05, 0.01, 0.06, 0.29, 0.0, 0.01, 0.23, 0.59, 0.2, 0.35, 0.67, 0.78, 0.76, 0.14, 0.74, 0.41, 0.0, 0.16, 0.0, 0.01, 0.14, 0.6, 0.12, 0.01, 0.63, 0.11, 0.57, 0.18, 0.0, 0.0, 0.2, 0.06, 0.0, 0.0, 0.08, 0.01, 0.11, 0.53, 0.17, 0.12, 0.0, 0.09, 0.18, 0.07, 0.56, 0.27, 0.33, 0.23, 0.01, 0.12, 0.01, 0.05, 0.0, 0.0, 0.0, 0.01, 0.0, 0.0, 0.0, 0.29, 0.01, 0.81, 0.88, 0.19, 0.69, 0.13, 0.08, 0.35, 0.21, 0.65, 0.64, 0.89, 0.58, 0.19, 0.42, 0.9, 0.32, 0.68, 0.6, 0.41, 0.57, 0.12, 0.51, 0.3, 0.75, 0.19, 0.62, 0.38, 0.69, 0.41, 0.03, 0.56, 0.55, 0.16, 0.11, 0.44, 0.34, 0.01, 0.36, 0.63, 0.05, 0.01, 0.65, 0.69, 0.0, 0.25, 0.6, 0.64, 0.49, 0.73, 0.8, 0.83, 0.86, 0.85, 0.94, 0.91, 0.73, 0.68, 0.86, 0.42, 0.88, 0.9, 0.72, 0.8, 0.61, 0.65, 0.67, 0.55, 0.66, 0.59, 0.49, 0.59, 0.41, 0.36, 0.56, 0.62, 0.73, 0.67, 0.62, 0.37, 0.48, 0.55, 0.87, 0.84, 0.5, 0.71, 0.68, 0.81]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
91.156905
0.278479
1,386
O60260
P33121
33082525, 23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ACSL1
MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV
Homo sapiens
Mitochondrion outer membrane, Peroxisome membrane, Microsome membrane, Endoplasmic reticulum membrane
Tissue enhanced (adipose tissue, liver, skeletal muscle)
{'Ciliated cells': '19.7', 'Basal respiratory cells': '13.3', 'Club cells': '30.9', 'Ionocytes': '43.8', 'Mucus glandular cells': '87.1', 'Serous glandular cells': '102.8', 'Gastric mucus-secreting cells': '40.7', 'Proximal enterocytes': '1.6', 'Paneth cells': '1.7', 'Distal enterocytes': '4.1', 'Intestinal goblet cells': '5.2', 'Exocrine glandular cells': '-0.374', 'Basal prostatic cells': '17.2', 'Prostatic glandular cells': '86.4', 'Breast glandular cells': '-0.477', 'Breast myoepithelial cells': '-0.591', 'Glandular and luminal cells': '22.6', 'Secretory cells': '3.4', 'Basal keratinocytes': '25.8', 'Suprabasal keratinocytes': '44.6', 'Basal squamous epithelial cells': '9.1', 'Squamous epithelial cells': '29.8', 'Alveolar cells type 1': '-0.012', 'Alveolar cells type 2': '0.028', 'Salivary duct cells': '39.0', 'Ductal cells': '0.402', 'Hepatocytes': '0.511', 'Cholangiocytes': '19.1', 'Proximal tubular cells': '0.520', 'Distal tubular cells': '61.5', 'Collecting duct cells': '33.1', 'Mesothelial cells': '-0.346', 'Sertoli cells': '-0.495', 'Granulosa cells': '1.1', 'Enteroendocrine cells': '3.2', 'Pancreatic endocrine cells': '11.9', 'Leydig cells': '-0.432', 'Excitatory neurons': '14.7', 'Inhibitory neurons': '21.9', 'Cone photoreceptor cells': '10.2', 'Rod photoreceptor cells': '10.7', 'Bipolar cells': '7.3', 'Horizontal cells': '5.7', 'Astrocytes': '6.2', 'Oligodendrocyte precursor cells': '8.0', 'Oligodendrocytes': '83.6', 'Microglial cells': '6.3', 'Muller glia cells': '5.1', 'Schwann cells': '-0.012', 'Spermatogonia': '-0.129', 'Spermatocytes': '0.164', 'Early spermatids': '0.546', 'Late spermatids': '0.655', 'Oocytes': '4.4', 'Cytotrophoblasts': '10.0', 'Syncytiotrophoblasts': '2.7', 'Extravillous trophoblasts': '2.3', 'Endothelial cells': '10.5', 'Lymphatic endothelial cells': '1.5', 'Cardiomyocytes': '0.700', 'Skeletal myocytes': '-0.354', 'Smooth muscle cells': '16.3', 'Adipocytes': '6.5', 'Melanocytes': '-0.092', 'Fibroblasts': '26.7', 'Peritubular cells': '-0.331', 'Endometrial stromal cells': '24.9', 'Ovarian stromal cells': '2.7', 'Undifferentiated cells': '1.8', 'T-cells': '8.7', 'B-cells': '16.1', 'Plasma cells': '10.8', 'Nk-cells': '5.1', 'Granulocytes': '15.3', 'Monocytes': '519.5', 'Macrophages': '200.2', 'Hofbauer cells': '67.8', 'Kupffer cells': '183.1', 'Dendritic cells': '69.8', 'Langerhans cells': '-0.009', 'Erythroid cells': '0.019', 'Adipocytes (Subcutaneous)': '0.772', 'Adipocytes (Visceral)': '0.813', 'Breast glandular cells (progenitors)': '-0.396', 'Adipocytes (Breast)': '0.894', 'Colon enterocytes': '-0.085', 'Colon enteroendocrine cells': '0.170', 'Enteric glia cells': '-0.310', 'Mitotic cells (Colon)': '0.055', 'Mitotic cells (Heart)': '0.402', 'Podocytes': '-0.117', 'Ascending Loop of Henle cells': '0.183', 'Intercalated cells': '-0.134', 'Cholangiocyte': '0.008', 'NK-cells (Liver)': '-0.056', 'Respiratory ciliated cells': '-0.117', 'Mitotic cells (Lung)': '-0.103', 'NK-cells (Lung)': '0.050', 'B-cells (Lung)': '0.014', 'Alpha cells': '0.245', 'Beta cells': '0.228', 'Prostate glandular cells': '0.714', 'Prostate basal glandular cells': '0.316', 'Urothelial cells': '-0.081', 'Keratinocyte (other)': '-0.130', 'Keratinocyte (granular)': '0.091', 'Hair cortex cells': '-0.035', 'Inner root sheath cells': '0.050', 'Outer root sheath cells': '0.055', 'Sebaceous gland cells': '0.587', 'Eccrine sweat gland cells': '0.056', 'Adipocytes (Skin)': '0.189', 'Mitotic cells (Skin)': '0.044', 'Parietal cells': '-0.215', 'Chief cells': '-0.049', 'Gastric mucous cells': '-0.131', 'Gastric enteroendocrine cells': '0.088', 'Mitotic cells (Stomach)': '0.121', 'Parafollicular cells': '-0.093', 'Thyroid glandular cells': '0.382', 'Mitotic cells (Thyroid)': '0.024', 'Adrenal cortex cells': '0.389', 'Adrenal medulla cells': '-0.028', 'Mitotic cells (Adrenal gland)': '0.354', 'Minor salivary glandular cells': '0.548', 'Minor salivary gland ductal cells': '-0.078', 'Minor salivary gland basal cells': '0.251', 'Mitotic cells (Minor salivary gland)': '0.358', 'Adipocytes (Minor salivary gland)': '0.448', 'Somatotropes': '0.109', 'Lactotropes': '-0.152', 'Gonadotropes': '-0.229', 'Corticotropes': '0.292', 'Thyrotropes': '-0.071', 'Undifferentiated cells (Pituitary gland)': '-0.237', 'Mitotic cells (Spleen)': '-0.113', 'Platelets': '0.244', 'Erythrocytes': '-0.023', 'Hematopoietic stem cells': '0.170', 'B-cells (Spleen)': '-0.061', 'NK-cells (Spleen)': '0.002', 'Amygdala excitatory': '28.8', 'Cerebellar inhibitory': '28.6', 'Cge interneuron': '28.4', 'Deep-layer corticothalamic and 6b': '32.2', 'Deep-layer intratelencephalic': '22.5', 'Deep-layer near-projecting': '35.8', 'Eccentric medium spiny neuron': '55.4', 'Hippocampal ca1-3': '38.4', 'Hippocampal ca4': '41.3', 'Hippocampal dentate gyrus': '32.7', 'Lamp5-lhx6 and chandelier': '28.5', 'Lower rhombic lip': '26.4', 'Mammillary body': '27.5', 'Medium spiny neuron': '39.9', 'Mge interneuron': '40.6', 'Midbrain-derived inhibitory': '31.6', 'Miscellaneous': '26.3', 'Splatter': '31.3', 'Thalamic excitatory': '28.1', 'Upper rhombic lip': '24.8', 'Upper-layer intratelencephalic': '20.4', 'Astrocyte': '9.9', 'Bergmann glia': '14.7', 'Central nervous system macrophage': '113.2', 'Choroid plexus epithelial cell': '117.0', 'Committed oligodendrocyte precursor': '42.5', 'Ependymal cell': '10.8', 'Oligodendrocyte': '122.6', 'Oligodendrocyte precursor cell': '14.9', 'Endothelial cell': '14.1', 'Pericyte': '9.0', 'Vascular associated smooth muscle cell': '23.2', 'Fibroblast': '21.3', 'Leukocyte': '68.9', 'Basophil': '93.3', 'Eosinophil': '17.2', 'Neutrophil': '4446.8', 'Classical monocyte': '302.4', 'Non-classical monocyte': '103.7', 'Intermediate monocyte': '143.0', 'T-reg': '8.6', 'GdT-cell': '3.2', 'MAIT T-cell': '9.5', 'Memory CD4 T-cell': '2.2', 'Naive CD4 T-cell': '16.5', 'Memory CD8 T-cell': '1.3', 'Naive CD8 T-cell': '9.9', 'Memory B-cell': '3.0', 'Naive B-cell': '18.3', 'Plasmacytoid DC': '11.6', 'Myeloid DC': '43.3', 'NK-cell': '16.8', 'Total PBMC': '96.4', 'Vd2 gdTCR': '8.9', 'Memory CD4 T-cell Th1\\/Th17': '14.1', 'Memory CD4 T-cell Th17': '12.2', 'Memory CD4 T-cell Th2': '15.3', 'Non-Vd2 gdTCR': '10.5', 'Memory CD4 T-cell Th1': '13.9', 'Memory CD4 T-cell TFH': '12.2', 'Terminal effector memory CD4 T-cell': '17.2', 'Central memory CD8 T-cell': '6.2', 'Effector memory CD8 T-cell': '6.2', 'Terminal effector memory CD8 T-cell': '11.4', 'Non-switched memory B-cell': '25.5', 'Plasmablast': '12.7', 'Switched memory B-cell': '27.8', 'Exhausted memory B-cell': '24.3', 'Progenitor cell': '39.0', 'Memory T-reg': '23.7', 'Naive CD4 T-cell activated': '63.9', 'Naive CD8 T-cell activated': '41.9', 'Naive T-reg': '17.9'}
null
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
90.526977
0.287536
1,031
O60260
P35232
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PHB1
MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ
Homo sapiens
Mitochondrion inner membrane, Nucleus, Cytoplasm, Cell membrane
Low tissue specificity
{'Ciliated cells': '79.5', 'Basal respiratory cells': '177.9', 'Club cells': '124.0', 'Ionocytes': '130.0', 'Mucus glandular cells': '136.4', 'Serous glandular cells': '218.9', 'Gastric mucus-secreting cells': '71.9', 'Proximal enterocytes': '149.9', 'Paneth cells': '170.8', 'Distal enterocytes': '240.4', 'Intestinal goblet cells': '208.4', 'Exocrine glandular cells': '-0.673', 'Basal prostatic cells': '103.6', 'Prostatic glandular cells': '110.3', 'Breast glandular cells': '0.168', 'Breast myoepithelial cells': '-0.135', 'Glandular and luminal cells': '141.1', 'Secretory cells': '148.3', 'Basal keratinocytes': '129.9', 'Suprabasal keratinocytes': '139.4', 'Basal squamous epithelial cells': '77.6', 'Squamous epithelial cells': '109.2', 'Alveolar cells type 1': '-0.095', 'Alveolar cells type 2': '0.314', 'Salivary duct cells': '97.3', 'Ductal cells': '0.603', 'Hepatocytes': '0.580', 'Cholangiocytes': '95.4', 'Proximal tubular cells': '0.444', 'Distal tubular cells': '341.2', 'Collecting duct cells': '89.5', 'Mesothelial cells': '0.019', 'Sertoli cells': '0.746', 'Granulosa cells': '94.9', 'Enteroendocrine cells': '215.7', 'Pancreatic endocrine cells': '205.5', 'Leydig cells': '0.699', 'Excitatory neurons': '7.6', 'Inhibitory neurons': '9.6', 'Cone photoreceptor cells': '61.2', 'Rod photoreceptor cells': '30.9', 'Bipolar cells': '39.8', 'Horizontal cells': '29.6', 'Astrocytes': '8.4', 'Oligodendrocyte precursor cells': '10.4', 'Oligodendrocytes': '14.3', 'Microglial cells': '1.8', 'Muller glia cells': '77.0', 'Schwann cells': '-0.009', 'Spermatogonia': '0.633', 'Spermatocytes': '0.169', 'Early spermatids': '-0.570', 'Late spermatids': '-0.644', 'Oocytes': '186.0', 'Cytotrophoblasts': '252.6', 'Syncytiotrophoblasts': '143.4', 'Extravillous trophoblasts': '288.6', 'Endothelial cells': '94.5', 'Lymphatic endothelial cells': '97.9', 'Cardiomyocytes': '0.741', 'Skeletal myocytes': '-0.042', 'Smooth muscle cells': '95.9', 'Adipocytes': '85.0', 'Melanocytes': '-0.009', 'Fibroblasts': '102.2', 'Peritubular cells': '0.509', 'Endometrial stromal cells': '90.3', 'Ovarian stromal cells': '114.2', 'Undifferentiated cells': '307.8', 'T-cells': '71.9', 'B-cells': '75.4', 'Plasma cells': '119.7', 'Nk-cells': '75.8', 'Granulocytes': '87.0', 'Monocytes': '44.7', 'Macrophages': '78.2', 'Hofbauer cells': '209.3', 'Kupffer cells': '47.8', 'Dendritic cells': '214.8', 'Langerhans cells': '-0.033', 'Erythroid cells': '-0.107', 'Adipocytes (Subcutaneous)': '0.440', 'Adipocytes (Visceral)': '0.367', 'Breast glandular cells (progenitors)': '0.101', 'Adipocytes (Breast)': '0.148', 'Colon enterocytes': '0.034', 'Colon enteroendocrine cells': '0.014', 'Enteric glia cells': '-0.266', 'Mitotic cells (Colon)': '0.049', 'Mitotic cells (Heart)': '0.460', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.331', 'Intercalated cells': '0.184', 'Cholangiocyte': '0.356', 'NK-cells (Liver)': '-0.412', 'Respiratory ciliated cells': '-0.127', 'Mitotic cells (Lung)': '0.194', 'NK-cells (Lung)': '-0.352', 'B-cells (Lung)': '-0.356', 'Alpha cells': '0.373', 'Beta cells': '0.218', 'Prostate glandular cells': '0.142', 'Prostate basal glandular cells': '0.203', 'Urothelial cells': '-0.059', 'Keratinocyte (other)': '-0.201', 'Keratinocyte (granular)': '-0.236', 'Hair cortex cells': '0.330', 'Inner root sheath cells': '0.347', 'Outer root sheath cells': '0.339', 'Sebaceous gland cells': '0.303', 'Eccrine sweat gland cells': '0.431', 'Adipocytes (Skin)': '0.248', 'Mitotic cells (Skin)': '0.258', 'Parietal cells': '-0.381', 'Chief cells': '-0.377', 'Gastric mucous cells': '-0.080', 'Gastric enteroendocrine cells': '-0.306', 'Mitotic cells (Stomach)': '0.363', 'Parafollicular cells': '0.102', 'Thyroid glandular cells': '0.522', 'Mitotic cells (Thyroid)': '-0.023', 'Adrenal cortex cells': '0.564', 'Adrenal medulla cells': '0.000', 'Mitotic cells (Adrenal gland)': '0.421', 'Minor salivary glandular cells': '0.498', 'Minor salivary gland ductal cells': '0.283', 'Minor salivary gland basal cells': '-0.452', 'Mitotic cells (Minor salivary gland)': '-0.421', 'Adipocytes (Minor salivary gland)': '-0.215', 'Somatotropes': '-0.131', 'Lactotropes': '-0.169', 'Gonadotropes': '-0.173', 'Corticotropes': '0.151', 'Thyrotropes': '0.173', 'Undifferentiated cells (Pituitary gland)': '0.264', 'Mitotic cells (Spleen)': '0.112', 'Platelets': '0.016', 'Erythrocytes': '-0.102', 'Hematopoietic stem cells': '0.024', 'B-cells (Spleen)': '0.198', 'NK-cells (Spleen)': '-0.090', 'Amygdala excitatory': '8.3', 'Cerebellar inhibitory': '22.1', 'Cge interneuron': '17.3', 'Deep-layer corticothalamic and 6b': '12.1', 'Deep-layer intratelencephalic': '10.2', 'Deep-layer near-projecting': '15.2', 'Eccentric medium spiny neuron': '11.0', 'Hippocampal ca1-3': '11.1', 'Hippocampal ca4': '15.5', 'Hippocampal dentate gyrus': '13.7', 'Lamp5-lhx6 and chandelier': '18.6', 'Lower rhombic lip': '16.9', 'Mammillary body': '12.5', 'Medium spiny neuron': '9.6', 'Mge interneuron': '16.7', 'Midbrain-derived inhibitory': '16.4', 'Miscellaneous': '13.5', 'Splatter': '18.3', 'Thalamic excitatory': '22.7', 'Upper rhombic lip': '15.7', 'Upper-layer intratelencephalic': '10.2', 'Astrocyte': '11.0', 'Bergmann glia': '19.1', 'Central nervous system macrophage': '12.1', 'Choroid plexus epithelial cell': '20.0', 'Committed oligodendrocyte precursor': '17.4', 'Ependymal cell': '18.1', 'Oligodendrocyte': '27.4', 'Oligodendrocyte precursor cell': '18.1', 'Endothelial cell': '21.1', 'Pericyte': '23.6', 'Vascular associated smooth muscle cell': '25.5', 'Fibroblast': '15.2', 'Leukocyte': '20.4', 'Basophil': '19.9', 'Eosinophil': '13.2', 'Neutrophil': '6.9', 'Classical monocyte': '14.2', 'Non-classical monocyte': '13.9', 'Intermediate monocyte': '65.2', 'T-reg': '75.3', 'GdT-cell': '61.9', 'MAIT T-cell': '83.4', 'Memory CD4 T-cell': '56.8', 'Naive CD4 T-cell': '17.1', 'Memory CD8 T-cell': '56.3', 'Naive CD8 T-cell': '18.9', 'Memory B-cell': '61.5', 'Naive B-cell': '9.3', 'Plasmacytoid DC': '221.6', 'Myeloid DC': '93.0', 'NK-cell': '22.7', 'Total PBMC': '83.4', 'Vd2 gdTCR': '97.9', 'Memory CD4 T-cell Th1\\/Th17': '17.0', 'Memory CD4 T-cell Th17': '19.2', 'Memory CD4 T-cell Th2': '18.2', 'Non-Vd2 gdTCR': '99.0', 'Memory CD4 T-cell Th1': '19.0', 'Memory CD4 T-cell TFH': '19.9', 'Terminal effector memory CD4 T-cell': '75.8', 'Central memory CD8 T-cell': '68.5', 'Effector memory CD8 T-cell': '81.2', 'Terminal effector memory CD8 T-cell': '97.6', 'Non-switched memory B-cell': '77.9', 'Plasmablast': '79.7', 'Switched memory B-cell': '86.3', 'Exhausted memory B-cell': '68.5', 'Progenitor cell': '55.7', 'Memory T-reg': '20.1', 'Naive CD4 T-cell activated': '90.6', 'Naive CD8 T-cell activated': '97.1', 'Naive T-reg': '18.2'}
null
{}
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[57.87, 65.42, 72.52, 71.83, 77.52, 77.99, 80.46, 81.32, 83.83, 84.21, 87.35, 87.01, 88.08, 88.92, 87.51, 89.34, 88.11, 87.45, 84.96, 85.47, 84.4, 83.5, 82.38, 81.24, 81.13, 82.56, 86.36, 86.22, 88.27, 89.74, 89.35, 88.5, 89.04, 92.04, 91.58, 90.25, 90.56, 89.41, 88.59, 88.05, 84.83, 86.58, 82.89, 87.68, 86.23, 85.34, 84.05, 85.84, 88.21, 89.39, 89.02, 89.39, 91.11, 89.11, 88.5, 87.57, 86.96, 86.33, 80.81, 81.89, 86.43, 88.16, 88.28, 89.46, 89.6, 90.97, 90.88, 91.07, 90.93, 92.96, 94.01, 93.51, 94.48, 92.74, 93.95, 93.7, 94.11, 94.13, 93.27, 92.43, 92.35, 92.25, 93.25, 92.99, 89.73, 90.54, 92.5, 93.27, 93.74, 93.96, 94.19, 94.34, 94.92, 94.75, 95.44, 94.84, 94.12, 94.03, 91.95, 89.14, 89.49, 89.19, 90.1, 90.77, 90.86, 91.43, 89.98, 89.5, 89.07, 89.64, 88.34, 86.14, 88.39, 87.42, 87.44, 88.88, 87.98, 90.29, 90.46, 92.41, 92.45, 93.97, 94.17, 93.66, 94.7, 95.26, 94.31, 94.19, 94.09, 93.78, 93.52, 93.77, 94.24, 94.41, 93.16, 90.49, 88.87, 91.92, 91.38, 89.0, 90.4, 92.18, 90.66, 91.97, 92.8, 92.82, 92.94, 93.77, 94.05, 95.37, 95.03, 95.09, 95.2, 95.23, 94.53, 94.67, 94.14, 93.65, 92.56, 91.93, 91.88, 91.48, 93.61, 93.76, 94.71, 93.04, 93.08, 94.04, 92.08, 92.17, 88.72, 86.08, 89.26, 91.19, 90.56, 88.19, 89.54, 89.46, 89.6, 89.25, 92.16, 90.15, 89.09, 90.94, 94.92, 91.71, 91.89, 95.18, 95.46, 94.74, 94.92, 96.04, 95.67, 96.26, 96.16, 95.99, 96.03, 96.42, 96.57, 95.46, 96.18, 96.55, 95.85, 96.17, 96.02, 95.77, 95.92, 96.06, 95.45, 96.4, 96.57, 95.9, 94.39, 95.46, 95.35, 96.32, 93.59, 94.22, 93.79, 92.72, 92.19, 91.78, 90.54, 86.81, 86.29, 87.43, 85.01, 81.82, 80.47, 81.58, 72.73, 75.54, 80.21, 81.58, 81.47, 83.55, 85.15, 86.78, 85.54, 90.11, 92.48, 93.6, 93.92, 90.89, 91.75, 91.64, 89.87, 86.61, 87.21, 87.63, 84.68, 80.54, 81.36, 82.04, 74.21, 76.28, 67.76, 70.69, 68.4, 70.33, 67.13, 62.03, 66.09, 61.4, 54.92, 53.64, 49.81, 57.19, 44.65, 48.45, 49.3, 43.56]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
88.015919
0.456801
2,388
O60260
P35998
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PSMC2
MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
Homo sapiens
Cytoplasm
Low tissue specificity
{'Ciliated cells': '45.8', 'Basal respiratory cells': '128.7', 'Club cells': '60.0', 'Ionocytes': '87.6', 'Mucus glandular cells': '32.0', 'Serous glandular cells': '55.1', 'Gastric mucus-secreting cells': '24.8', 'Proximal enterocytes': '44.9', 'Paneth cells': '32.2', 'Distal enterocytes': '34.5', 'Intestinal goblet cells': '37.3', 'Exocrine glandular cells': '-0.588', 'Basal prostatic cells': '40.7', 'Prostatic glandular cells': '43.7', 'Breast glandular cells': '-0.023', 'Breast myoepithelial cells': '-0.018', 'Glandular and luminal cells': '26.5', 'Secretory cells': '43.5', 'Basal keratinocytes': '50.9', 'Suprabasal keratinocytes': '68.2', 'Basal squamous epithelial cells': '24.4', 'Squamous epithelial cells': '23.9', 'Alveolar cells type 1': '-0.056', 'Alveolar cells type 2': '0.288', 'Salivary duct cells': '32.5', 'Ductal cells': '0.625', 'Hepatocytes': '0.585', 'Cholangiocytes': '40.1', 'Proximal tubular cells': '0.260', 'Distal tubular cells': '33.8', 'Collecting duct cells': '31.1', 'Mesothelial cells': '0.168', 'Sertoli cells': '-0.184', 'Granulosa cells': '38.1', 'Enteroendocrine cells': '30.1', 'Pancreatic endocrine cells': '101.9', 'Leydig cells': '-0.086', 'Excitatory neurons': '27.0', 'Inhibitory neurons': '24.0', 'Cone photoreceptor cells': '49.3', 'Rod photoreceptor cells': '45.6', 'Bipolar cells': '41.3', 'Horizontal cells': '28.3', 'Astrocytes': '17.3', 'Oligodendrocyte precursor cells': '19.8', 'Oligodendrocytes': '30.6', 'Microglial cells': '15.2', 'Muller glia cells': '65.2', 'Schwann cells': '0.068', 'Spermatogonia': '0.197', 'Spermatocytes': '0.448', 'Early spermatids': '0.711', 'Late spermatids': '0.222', 'Oocytes': '73.5', 'Cytotrophoblasts': '176.5', 'Syncytiotrophoblasts': '236.6', 'Extravillous trophoblasts': '116.2', 'Endothelial cells': '45.8', 'Lymphatic endothelial cells': '35.1', 'Cardiomyocytes': '0.699', 'Skeletal myocytes': '-0.263', 'Smooth muscle cells': '51.2', 'Adipocytes': '35.0', 'Melanocytes': '0.385', 'Fibroblasts': '53.6', 'Peritubular cells': '-0.048', 'Endometrial stromal cells': '34.4', 'Ovarian stromal cells': '46.8', 'Undifferentiated cells': '43.6', 'T-cells': '38.3', 'B-cells': '29.5', 'Plasma cells': '63.8', 'Nk-cells': '39.1', 'Granulocytes': '65.7', 'Monocytes': '36.4', 'Macrophages': '50.2', 'Hofbauer cells': '117.2', 'Kupffer cells': '45.9', 'Dendritic cells': '41.5', 'Langerhans cells': '0.338', 'Erythroid cells': '-0.108', 'Adipocytes (Subcutaneous)': '0.073', 'Adipocytes (Visceral)': '0.111', 'Breast glandular cells (progenitors)': '-0.146', 'Adipocytes (Breast)': '0.174', 'Colon enterocytes': '-0.165', 'Colon enteroendocrine cells': '0.220', 'Enteric glia cells': '-0.259', 'Mitotic cells (Colon)': '-0.103', 'Mitotic cells (Heart)': '0.496', 'Podocytes': '-0.028', 'Ascending Loop of Henle cells': '0.426', 'Intercalated cells': '0.045', 'Cholangiocyte': '0.340', 'NK-cells (Liver)': '-0.368', 'Respiratory ciliated cells': '-0.127', 'Mitotic cells (Lung)': '0.237', 'NK-cells (Lung)': '-0.184', 'B-cells (Lung)': '-0.267', 'Alpha cells': '0.373', 'Beta cells': '0.239', 'Prostate glandular cells': '0.027', 'Prostate basal glandular cells': '0.068', 'Urothelial cells': '-0.167', 'Keratinocyte (other)': '0.353', 'Keratinocyte (granular)': '0.061', 'Hair cortex cells': '0.150', 'Inner root sheath cells': '0.206', 'Outer root sheath cells': '0.192', 'Sebaceous gland cells': '0.061', 'Eccrine sweat gland cells': '-0.163', 'Adipocytes (Skin)': '-0.208', 'Mitotic cells (Skin)': '0.436', 'Parietal cells': '-0.591', 'Chief cells': '-0.537', 'Gastric mucous cells': '-0.235', 'Gastric enteroendocrine cells': '-0.438', 'Mitotic cells (Stomach)': '0.223', 'Parafollicular cells': '0.093', 'Thyroid glandular cells': '0.311', 'Mitotic cells (Thyroid)': '-0.043', 'Adrenal cortex cells': '0.554', 'Adrenal medulla cells': '0.099', 'Mitotic cells (Adrenal gland)': '0.429', 'Minor salivary glandular cells': '0.195', 'Minor salivary gland ductal cells': '-0.281', 'Minor salivary gland basal cells': '0.563', 'Mitotic cells (Minor salivary gland)': '0.642', 'Adipocytes (Minor salivary gland)': '0.169', 'Somatotropes': '-0.002', 'Lactotropes': '0.013', 'Gonadotropes': '0.072', 'Corticotropes': '0.015', 'Thyrotropes': '0.219', 'Undifferentiated cells (Pituitary gland)': '0.153', 'Mitotic cells (Spleen)': '0.105', 'Platelets': '0.066', 'Erythrocytes': '-0.065', 'Hematopoietic stem cells': '0.029', 'B-cells (Spleen)': '0.005', 'NK-cells (Spleen)': '-0.006', 'Amygdala excitatory': '33.1', 'Cerebellar inhibitory': '37.9', 'Cge interneuron': '32.8', 'Deep-layer corticothalamic and 6b': '32.2', 'Deep-layer intratelencephalic': '35.1', 'Deep-layer near-projecting': '35.8', 'Eccentric medium spiny neuron': '35.4', 'Hippocampal ca1-3': '35.7', 'Hippocampal ca4': '38.4', 'Hippocampal dentate gyrus': '42.7', 'Lamp5-lhx6 and chandelier': '33.7', 'Lower rhombic lip': '42.4', 'Mammillary body': '40.9', 'Medium spiny neuron': '34.3', 'Mge interneuron': '33.4', 'Midbrain-derived inhibitory': '41.2', 'Miscellaneous': '34.4', 'Splatter': '36.4', 'Thalamic excitatory': '41.5', 'Upper rhombic lip': '42.5', 'Upper-layer intratelencephalic': '34.3', 'Astrocyte': '31.9', 'Bergmann glia': '40.0', 'Central nervous system macrophage': '30.8', 'Choroid plexus epithelial cell': '33.9', 'Committed oligodendrocyte precursor': '34.2', 'Ependymal cell': '23.2', 'Oligodendrocyte': '46.8', 'Oligodendrocyte precursor cell': '36.8', 'Endothelial cell': '32.4', 'Pericyte': '41.8', 'Vascular associated smooth muscle cell': '21.8', 'Fibroblast': '32.7', 'Leukocyte': '25.7', 'Basophil': '53.7', 'Eosinophil': '52.9', 'Neutrophil': '9.6', 'Classical monocyte': '49.8', 'Non-classical monocyte': '102.0', 'Intermediate monocyte': '83.2', 'T-reg': '29.1', 'GdT-cell': '44.8', 'MAIT T-cell': '22.1', 'Memory CD4 T-cell': '51.2', 'Naive CD4 T-cell': '71.3', 'Memory CD8 T-cell': '47.9', 'Naive CD8 T-cell': '57.6', 'Memory B-cell': '47.7', 'Naive B-cell': '48.9', 'Plasmacytoid DC': '52.0', 'Myeloid DC': '88.3', 'NK-cell': '87.0', 'Total PBMC': '43.8', 'Vd2 gdTCR': '26.5', 'Memory CD4 T-cell TFH': '82.3', 'Memory CD4 T-cell Th2': '99.2', 'Memory CD4 T-cell Th17': '92.3', 'Memory CD4 T-cell Th1\\/Th17': '86.6', 'Non-Vd2 gdTCR': '21.9', 'Memory CD4 T-cell Th1': '82.3', 'Terminal effector memory CD4 T-cell': '28.4', 'Central memory CD8 T-cell': '17.9', 'Effector memory CD8 T-cell': '49.9', 'Terminal effector memory CD8 T-cell': '21.6', 'Switched memory B-cell': '25.4', 'Plasmablast': '116.6', 'Non-switched memory B-cell': '18.9', 'Exhausted memory B-cell': '26.1', 'Progenitor cell': '35.9', 'Naive CD4 T-cell activated': '95.1', 'Naive CD8 T-cell activated': '101.9', 'Memory T-reg': '97.0', 'Naive T-reg': '70.8'}
5GJQ, 5GJR, 5L4G, 5LN3, 5M32, 5T0C, 5T0G, 5T0H, 5T0I, 5T0J, 5VFP, 5VFQ, 5VFR, 5VFS, 5VFT, 5VFU, 5VGZ, 5VHF, 5VHH, 5VHI, 5VHJ, 5VHM, 5VHN, 5VHO, 5VHP, 5VHQ, 5VHR, 5VHS, 6MSB, 6MSD, 6MSE, 6MSG, 6MSH, 6MSJ, 6MSK, 6WJD, 6WJN, 7QXN, 7QXP, 7QXU, 7QXW, 7QXX, 7QY7, 7QYA, 7QYB, 7W37, 7W38, 7W39, 7W3A, 7W3B, 7W3C, 7W3F, 7W3G, 7W3H, 7W3I, 7W3J, 7W3K, 7W3M, 8CVT
{'Adipose Tissue': 51.02107973421926, 'Adrenal Gland': 51.17467441860465, 'Bladder': 48.86, 'Blood': 26.092794402583426, 'Blood Vessel': 63.62797752808989, 'Brain': 32.760683194549586, 'Breast': 49.00389978213508, 'Cervix Uteri': 50.602631578947374, 'Colon': 43.082888318356865, 'Esophagus': 47.84765951557094, 'Fallopian Tube': 52.696666666666665, 'Heart': 28.212132404181187, 'Kidney': 26.52248314606742, 'Liver': 31.233920353982302, 'Lung': 52.796730103806226, 'Muscle': 74.37696139476961, 'Nerve': 57.8980775444265, 'Ovary': 46.153055555555554, 'Pancreas': 13.581698170731704, 'Pituitary': 49.76024734982333, 'Prostate': 43.80118367346939, 'Salivary Gland': 38.84358024691358, 'Skin': 62.98060254284135, 'Small Intestine': 39.05395721925134, 'Spleen': 47.677468879668055, 'Stomach': 36.100949860724235, 'Testis': 52.91279778393352, 'Thyroid': 50.467932618683, 'Uterus': 56.406549295774646, 'Vagina': 47.328141025641024}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
79.648822
0.428568
1,808
O60260
P37840
11431533, 17883392, E3Net
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
SNCA
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
Homo sapiens
Cytoplasm, Membrane, Nucleus, Synapse, Secreted, Cell projection, axon
Group enriched (bone marrow, brain)
{'Ciliated cells': '4.7', 'Basal respiratory cells': '163.5', 'Club cells': '16.7', 'Ionocytes': '44.2', 'Mucus glandular cells': '3.0', 'Serous glandular cells': '5.7', 'Gastric mucus-secreting cells': '0.0', 'Proximal enterocytes': '0.1', 'Paneth cells': '0.0', 'Distal enterocytes': '0.0', 'Intestinal goblet cells': '0.2', 'Exocrine glandular cells': '-0.480', 'Basal prostatic cells': '7.8', 'Prostatic glandular cells': '11.9', 'Breast glandular cells': '0.369', 'Breast myoepithelial cells': '0.612', 'Glandular and luminal cells': '0.3', 'Secretory cells': '0.8', 'Basal keratinocytes': '55.5', 'Suprabasal keratinocytes': '18.3', 'Basal squamous epithelial cells': '50.1', 'Squamous epithelial cells': '1.4', 'Alveolar cells type 1': '0.188', 'Alveolar cells type 2': '-0.391', 'Salivary duct cells': '18.1', 'Ductal cells': '0.560', 'Hepatocytes': '-0.038', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.043', 'Distal tubular cells': '3.1', 'Collecting duct cells': '11.7', 'Mesothelial cells': '0.759', 'Sertoli cells': '0.297', 'Granulosa cells': '39.1', 'Enteroendocrine cells': '0.6', 'Pancreatic endocrine cells': '3.4', 'Leydig cells': '0.486', 'Excitatory neurons': '243.0', 'Inhibitory neurons': '51.5', 'Cone photoreceptor cells': '0.0', 'Rod photoreceptor cells': '3.6', 'Bipolar cells': '5.3', 'Horizontal cells': '32.7', 'Astrocytes': '38.1', 'Oligodendrocyte precursor cells': '89.6', 'Oligodendrocytes': '181.8', 'Microglial cells': '73.4', 'Muller glia cells': '16.7', 'Schwann cells': '0.515', 'Spermatogonia': '0.413', 'Spermatocytes': '0.308', 'Early spermatids': '-0.305', 'Late spermatids': '-0.403', 'Oocytes': '1.5', 'Cytotrophoblasts': '20.1', 'Syncytiotrophoblasts': '7.6', 'Extravillous trophoblasts': '1.3', 'Endothelial cells': '22.6', 'Lymphatic endothelial cells': '71.4', 'Cardiomyocytes': '0.541', 'Skeletal myocytes': '-0.062', 'Smooth muscle cells': '4.1', 'Adipocytes': '1.9', 'Melanocytes': '0.285', 'Fibroblasts': '10.2', 'Peritubular cells': '0.307', 'Endometrial stromal cells': '1.0', 'Ovarian stromal cells': '45.0', 'Undifferentiated cells': '0.2', 'T-cells': '3.6', 'B-cells': '3.0', 'Plasma cells': '0.7', 'Nk-cells': '2.7', 'Granulocytes': '5.9', 'Monocytes': '9.8', 'Macrophages': '34.2', 'Hofbauer cells': '57.8', 'Kupffer cells': '11.8', 'Dendritic cells': '44.9', 'Langerhans cells': '-0.001', 'Erythroid cells': '0.629', 'Adipocytes (Subcutaneous)': '-0.352', 'Adipocytes (Visceral)': '-0.353', 'Breast glandular cells (progenitors)': '0.303', 'Adipocytes (Breast)': '-0.413', 'Colon enterocytes': '-0.222', 'Colon enteroendocrine cells': '0.446', 'Enteric glia cells': '0.885', 'Mitotic cells (Colon)': '-0.170', 'Mitotic cells (Heart)': '0.353', 'Podocytes': '0.574', 'Ascending Loop of Henle cells': '0.037', 'Intercalated cells': '0.278', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.124', 'Respiratory ciliated cells': '-0.033', 'Mitotic cells (Lung)': '-0.078', 'NK-cells (Lung)': '0.291', 'B-cells (Lung)': '0.102', 'Alpha cells': '0.459', 'Beta cells': '0.256', 'Prostate glandular cells': '0.037', 'Prostate basal glandular cells': '-0.020', 'Urothelial cells': '-0.048', 'Keratinocyte (other)': '-0.015', 'Keratinocyte (granular)': '-0.136', 'Hair cortex cells': '0.087', 'Inner root sheath cells': '0.123', 'Outer root sheath cells': '0.144', 'Sebaceous gland cells': '-0.011', 'Eccrine sweat gland cells': '0.502', 'Adipocytes (Skin)': '0.108', 'Mitotic cells (Skin)': '0.333', 'Parietal cells': '-0.770', 'Chief cells': '-0.580', 'Gastric mucous cells': '-0.653', 'Gastric enteroendocrine cells': '-0.399', 'Mitotic cells (Stomach)': '-0.250', 'Parafollicular cells': '0.134', 'Thyroid glandular cells': '0.428', 'Mitotic cells (Thyroid)': '0.084', 'Adrenal cortex cells': '0.250', 'Adrenal medulla cells': '0.517', 'Mitotic cells (Adrenal gland)': '0.313', 'Minor salivary glandular cells': '0.307', 'Minor salivary gland ductal cells': '0.347', 'Minor salivary gland basal cells': '-0.062', 'Mitotic cells (Minor salivary gland)': '-0.149', 'Adipocytes (Minor salivary gland)': '-0.035', 'Somatotropes': '0.071', 'Lactotropes': '0.543', 'Gonadotropes': '0.333', 'Corticotropes': '0.250', 'Thyrotropes': '0.415', 'Undifferentiated cells (Pituitary gland)': '-0.149', 'Mitotic cells (Spleen)': '0.134', 'Platelets': '0.278', 'Erythrocytes': '0.767', 'Hematopoietic stem cells': '0.295', 'B-cells (Spleen)': '-0.194', 'NK-cells (Spleen)': '0.124', 'Amygdala excitatory': '297.2', 'Cerebellar inhibitory': '73.3', 'Cge interneuron': '95.3', 'Deep-layer corticothalamic and 6b': '333.1', 'Deep-layer intratelencephalic': '395.0', 'Deep-layer near-projecting': '341.2', 'Eccentric medium spiny neuron': '229.3', 'Hippocampal ca1-3': '245.8', 'Hippocampal ca4': '318.2', 'Hippocampal dentate gyrus': '244.4', 'Lamp5-lhx6 and chandelier': '41.2', 'Lower rhombic lip': '362.4', 'Mammillary body': '497.0', 'Medium spiny neuron': '207.3', 'Mge interneuron': '72.8', 'Midbrain-derived inhibitory': '63.1', 'Miscellaneous': '202.6', 'Splatter': '109.2', 'Thalamic excitatory': '174.8', 'Upper rhombic lip': '378.1', 'Upper-layer intratelencephalic': '272.3', 'Astrocyte': '31.5', 'Bergmann glia': '64.5', 'Central nervous system macrophage': '326.0', 'Choroid plexus epithelial cell': '43.1', 'Committed oligodendrocyte precursor': '126.6', 'Ependymal cell': '126.1', 'Oligodendrocyte': '222.1', 'Oligodendrocyte precursor cell': '145.9', 'Endothelial cell': '12.0', 'Pericyte': '7.5', 'Vascular associated smooth muscle cell': '12.2', 'Fibroblast': '16.6', 'Leukocyte': '14.8', 'Basophil': '14.6', 'Eosinophil': '0.1', 'Neutrophil': '27.0', 'Classical monocyte': '5.7', 'Non-classical monocyte': '0.9', 'Intermediate monocyte': '22.3', 'T-reg': '0.6', 'GdT-cell': '0.3', 'MAIT T-cell': '0.4', 'Memory CD4 T-cell': '1.9', 'Naive CD4 T-cell': '0.0', 'Memory CD8 T-cell': '0.3', 'Naive CD8 T-cell': '0.0', 'Memory B-cell': '4.2', 'Naive B-cell': '0.2', 'Plasmacytoid DC': '128.3', 'Myeloid DC': '64.3', 'NK-cell': '0.1', 'Total PBMC': '218.8', 'Vd2 gdTCR': '1.1', 'Memory CD4 T-cell Th1\\/Th17': '0.1', 'Memory CD4 T-cell Th17': '0.1', 'Memory CD4 T-cell Th2': '0.1', 'Non-Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1': '0.3', 'Memory CD4 T-cell TFH': '0.1', 'Terminal effector memory CD4 T-cell': '0.4', 'Central memory CD8 T-cell': '0.7', 'Effector memory CD8 T-cell': '0.2', 'Terminal effector memory CD8 T-cell': '0.4', 'Non-switched memory B-cell': '130.3', 'Plasmablast': '31.1', 'Switched memory B-cell': '122.8', 'Exhausted memory B-cell': '107.7', 'Progenitor cell': '100.3', 'Memory T-reg': '0.0', 'Naive CD4 T-cell activated': '0.0', 'Naive CD8 T-cell activated': '0.0', 'Naive T-reg': '0.1'}
1XQ8, 2JN5, 2KKW, 2M55, 2N0A, 2X6M, 3Q25, 3Q26, 3Q27, 3Q28, 3Q29, 4BXL, 4R0U, 4R0W, 4RIK, 4RIL, 4ZNN, 5CRW, 6A6B, 6CT7, 6CU7, 6CU8, 6H6B, 6I42, 6L1T, 6L1U, 6L4S, 6LRQ, 6OSJ, 6OSL, 6OSM, 6PEO, 6PES, 6RT0, 6RTB, 6SST, 6SSX, 6UFR, 6XYO, 6XYP, 6XYQ, 7C1D, 7E0F, 7L7H, 7LC9, 7NCA, 7NCG, 7NCH, 7NCI, 7NCJ, 7NCK, 7OZG, 7OZH, 7STX, 7UAK, 7V47, 7V48, 7V49, 7V4A, 7V4B, 7V4C, 7V4D, 7WMM, 7WNZ, 7WO0, 7XJX, 7XO0, 7XO1, 7XO2, 7XO3, 7YK2, 7YK8, 7YNF, 7YNG, 7YNL, 7YNM, 7YNN, 7YNO, 7YNP, 7YNQ, 7YNR, 7YNS, 7YNT, 8A4L, 8A9L, 8ADS, 8ADU, 8ADV, 8ADW, 8AEX, 8B9V, 8BQV, 8BQW, 8CE7, 8CEB, 8CYR, 8CYS, 8CYT, 8CYV, 8CYW, 8CYX, 8CYY, 8CZ0, 8CZ1, 8CZ2, 8CZ3, 8CZ6, 8FPT, 8G0L, 8GF7, 8H03, 8H04, 8H05, 8HZB, 8HZC, 8HZS, 8JEX, 8JEY, 8JJV, 8JLY, 8OG0, 8OJR, 8OQI, 8PIC, 8PIX, 8PJO, 8PK2, 8PK4, 8RI9, 8RQM, 8RRR, 9EUU
{'Adipose Tissue': 5.085204235880399, 'Adrenal Gland': 1.590537984496124, 'Bladder': 4.148190476190476, 'Blood': 37.00204484176534, 'Blood Vessel': 2.890340674157303, 'Brain': 57.2600340651022, 'Breast': 3.567399782135076, 'Cervix Uteri': 13.350473684210526, 'Colon': 9.627345057766368, 'Esophagus': 5.795383598615916, 'Fallopian Tube': 6.501111111111111, 'Heart': 1.9446371080139373, 'Kidney': 3.261140449438202, 'Liver': 0.4120822566371681, 'Lung': 7.752586505190311, 'Muscle': 0.2176021170610211, 'Nerve': 70.22833602584815, 'Ovary': 14.524172222222225, 'Pancreas': 0.3556800609756098, 'Pituitary': 13.279452296819787, 'Prostate': 8.63124081632653, 'Salivary Gland': 5.64714938271605, 'Skin': 4.770989058043118, 'Small Intestine': 4.111259893048128, 'Spleen': 5.624929460580913, 'Stomach': 2.570770529247911, 'Testis': 1.40186648199446, 'Thyroid': 4.875612251148546, 'Uterus': 21.73145774647887, 'Vagina': 12.69951923076923}
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[76.65, 84.26, 82.34, 81.61, 85.45, 82.64, 85.83, 88.01, 87.03, 84.94, 84.96, 88.35, 86.01, 87.98, 89.88, 91.1, 89.83, 88.53, 89.62, 89.99, 92.69, 90.61, 90.72, 91.31, 89.9, 92.5, 92.13, 91.25, 91.24, 91.13, 92.47, 93.85, 91.16, 92.67, 90.38, 92.69, 92.93, 93.68, 92.8, 91.54, 91.7, 91.12, 91.02, 88.65, 87.88, 84.13, 87.36, 90.26, 87.91, 87.27, 87.48, 88.6, 86.55, 86.69, 87.34, 83.47, 85.55, 88.94, 86.83, 85.14, 82.11, 80.68, 85.16, 85.07, 85.24, 86.36, 85.79, 86.88, 87.11, 91.8, 88.93, 87.99, 87.81, 91.44, 88.74, 88.15, 89.89, 87.49, 86.91, 87.57, 83.77, 82.39, 78.05, 76.85, 73.7, 69.85, 76.46, 70.11, 58.92, 59.54, 62.77, 63.19, 54.69, 52.57, 53.29, 53.73, 52.62, 46.07, 45.5, 46.03, 40.58, 41.18, 43.31, 45.25, 44.45, 40.58, 46.38, 49.3, 43.98, 45.44, 43.78, 46.74, 47.63, 45.07, 49.82, 49.1, 53.5, 55.02, 53.52, 59.23, 56.16, 54.82, 53.31, 51.31, 57.59, 52.18, 50.28, 54.72, 52.75, 53.81, 52.12, 49.58, 50.67, 50.41, 56.11, 57.11, 61.68, 63.85, 61.75, 59.16]
[0.79, 0.78, 0.84, 0.81, 0.63, 0.66, 0.47, 0.52, 0.44, 0.65, 0.48, 0.59, 0.64, 0.46, 0.65, 0.56, 0.54, 0.49, 0.44, 0.57, 0.74, 0.57, 0.7, 0.62, 0.45, 0.61, 0.58, 0.61, 0.48, 0.46, 0.42, 0.69, 0.59, 0.68, 0.7, 0.39, 0.64, 0.65, 0.65, 0.61, 0.45, 0.49, 0.49, 0.54, 0.69, 0.55, 0.51, 0.54, 0.59, 0.68, 0.33, 0.62, 0.49, 0.38, 0.61, 0.55, 0.56, 0.62, 0.48, 0.63, 0.61, 0.67, 0.64, 0.67, 0.68, 0.62, 0.37, 0.38, 0.56, 0.57, 0.62, 0.64, 0.4, 0.6, 0.45, 0.4, 0.62, 0.48, 0.57, 0.72, 0.59, 0.71, 0.67, 0.3, 0.5, 0.47, 0.56, 0.61, 0.39, 0.67, 0.78, 0.63, 0.62, 0.79, 0.6, 0.78, 0.86, 0.87, 0.95, 0.97, 0.87, 0.97, 0.98, 0.93, 0.96, 0.72, 0.79, 0.82, 0.9, 0.84, 0.65, 0.8, 0.88, 0.81, 0.88, 0.85, 0.82, 0.83, 0.63, 0.81, 0.81, 0.65, 0.82, 0.6, 0.89, 0.9, 0.82, 0.84, 0.73, 0.69, 0.89, 0.81, 0.82, 0.85, 0.84, 0.87, 0.84, 0.84, 0.95, 0.95]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
74.007143
0.659929
2,916
O60260
P40222
33082525
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
TXLNA
MKNQDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSAGGQGSLTDSGPERRPEGPGAQAPSSPRVTEAPCYPGAPSTEASGQTGPQEPTSARA
Homo sapiens
null
Low tissue specificity
{'Ciliated cells': '23.6', 'Basal respiratory cells': '13.4', 'Club cells': '18.6', 'Ionocytes': '10.7', 'Mucus glandular cells': '25.3', 'Serous glandular cells': '25.8', 'Gastric mucus-secreting cells': '21.2', 'Proximal enterocytes': '7.0', 'Paneth cells': '6.7', 'Distal enterocytes': '13.7', 'Intestinal goblet cells': '14.6', 'Exocrine glandular cells': '-0.739', 'Basal prostatic cells': '26.0', 'Prostatic glandular cells': '24.8', 'Breast glandular cells': '0.433', 'Breast myoepithelial cells': '0.315', 'Glandular and luminal cells': '26.1', 'Secretory cells': '21.7', 'Basal keratinocytes': '19.9', 'Suprabasal keratinocytes': '18.3', 'Basal squamous epithelial cells': '18.2', 'Squamous epithelial cells': '20.4', 'Alveolar cells type 1': '-0.061', 'Alveolar cells type 2': '-0.190', 'Salivary duct cells': '27.2', 'Ductal cells': '0.667', 'Hepatocytes': '0.258', 'Cholangiocytes': '11.4', 'Proximal tubular cells': '0.185', 'Distal tubular cells': '3.1', 'Collecting duct cells': '11.7', 'Mesothelial cells': '0.104', 'Sertoli cells': '0.241', 'Granulosa cells': '16.5', 'Enteroendocrine cells': '22.9', 'Pancreatic endocrine cells': '8.5', 'Leydig cells': '0.209', 'Excitatory neurons': '9.4', 'Inhibitory neurons': '9.1', 'Cone photoreceptor cells': '17.0', 'Rod photoreceptor cells': '28.3', 'Bipolar cells': '16.7', 'Horizontal cells': '20.8', 'Astrocytes': '12.7', 'Oligodendrocyte precursor cells': '9.0', 'Oligodendrocytes': '12.0', 'Microglial cells': '7.2', 'Muller glia cells': '13.2', 'Schwann cells': '0.095', 'Spermatogonia': '0.328', 'Spermatocytes': '0.438', 'Early spermatids': '-0.027', 'Late spermatids': '-0.215', 'Oocytes': '4.4', 'Cytotrophoblasts': '10.7', 'Syncytiotrophoblasts': '7.6', 'Extravillous trophoblasts': '14.6', 'Endothelial cells': '26.2', 'Lymphatic endothelial cells': '21.8', 'Cardiomyocytes': '0.317', 'Skeletal myocytes': '-0.206', 'Smooth muscle cells': '27.3', 'Adipocytes': '24.1', 'Melanocytes': '-0.027', 'Fibroblasts': '31.7', 'Peritubular cells': '0.152', 'Endometrial stromal cells': '43.0', 'Ovarian stromal cells': '15.0', 'Undifferentiated cells': '14.0', 'T-cells': '17.9', 'B-cells': '11.8', 'Plasma cells': '29.4', 'Nk-cells': '20.3', 'Granulocytes': '26.8', 'Monocytes': '28.8', 'Macrophages': '19.7', 'Hofbauer cells': '17.2', 'Kupffer cells': '12.2', 'Dendritic cells': '24.9', 'Langerhans cells': '0.145', 'Erythroid cells': '-0.193', 'Adipocytes (Subcutaneous)': '-0.076', 'Adipocytes (Visceral)': '-0.056', 'Breast glandular cells (progenitors)': '0.366', 'Adipocytes (Breast)': '-0.299', 'Colon enterocytes': '-0.180', 'Colon enteroendocrine cells': '0.147', 'Enteric glia cells': '0.126', 'Mitotic cells (Colon)': '-0.136', 'Mitotic cells (Heart)': '0.435', 'Podocytes': '-0.161', 'Ascending Loop of Henle cells': '0.343', 'Intercalated cells': '-0.138', 'Cholangiocyte': '0.177', 'NK-cells (Liver)': '-0.301', 'Respiratory ciliated cells': '0.005', 'Mitotic cells (Lung)': '0.036', 'NK-cells (Lung)': '0.081', 'B-cells (Lung)': '-0.059', 'Alpha cells': '0.418', 'Beta cells': '0.264', 'Prostate glandular cells': '-0.257', 'Prostate basal glandular cells': '0.225', 'Urothelial cells': '0.336', 'Keratinocyte (other)': '-0.137', 'Keratinocyte (granular)': '0.229', 'Hair cortex cells': '-0.055', 'Inner root sheath cells': '-0.055', 'Outer root sheath cells': '-0.090', 'Sebaceous gland cells': '0.389', 'Eccrine sweat gland cells': '-0.060', 'Adipocytes (Skin)': '0.231', 'Mitotic cells (Skin)': '0.012', 'Parietal cells': '-0.683', 'Chief cells': '-0.551', 'Gastric mucous cells': '-0.351', 'Gastric enteroendocrine cells': '-0.397', 'Mitotic cells (Stomach)': '0.107', 'Parafollicular cells': '0.038', 'Thyroid glandular cells': '0.156', 'Mitotic cells (Thyroid)': '-0.001', 'Adrenal cortex cells': '0.292', 'Adrenal medulla cells': '-0.021', 'Mitotic cells (Adrenal gland)': '0.195', 'Minor salivary glandular cells': '0.619', 'Minor salivary gland ductal cells': '0.158', 'Minor salivary gland basal cells': '0.166', 'Mitotic cells (Minor salivary gland)': '0.258', 'Adipocytes (Minor salivary gland)': '0.063', 'Somatotropes': '-0.093', 'Lactotropes': '-0.215', 'Gonadotropes': '-0.042', 'Corticotropes': '0.026', 'Thyrotropes': '-0.026', 'Undifferentiated cells (Pituitary gland)': '0.202', 'Mitotic cells (Spleen)': '-0.050', 'Platelets': '-0.133', 'Erythrocytes': '-0.041', 'Hematopoietic stem cells': '-0.293', 'B-cells (Spleen)': '0.243', 'NK-cells (Spleen)': '0.130', 'Amygdala excitatory': '15.6', 'Cerebellar inhibitory': '14.8', 'Cge interneuron': '17.9', 'Deep-layer corticothalamic and 6b': '15.9', 'Deep-layer intratelencephalic': '16.7', 'Deep-layer near-projecting': '13.7', 'Eccentric medium spiny neuron': '18.3', 'Hippocampal ca1-3': '16.1', 'Hippocampal ca4': '15.3', 'Hippocampal dentate gyrus': '14.7', 'Lamp5-lhx6 and chandelier': '15.2', 'Lower rhombic lip': '11.3', 'Mammillary body': '16.7', 'Medium spiny neuron': '18.6', 'Mge interneuron': '12.7', 'Midbrain-derived inhibitory': '13.5', 'Miscellaneous': '18.5', 'Splatter': '13.5', 'Thalamic excitatory': '15.4', 'Upper rhombic lip': '15.4', 'Upper-layer intratelencephalic': '16.8', 'Astrocyte': '22.8', 'Bergmann glia': '24.0', 'Central nervous system macrophage': '23.2', 'Choroid plexus epithelial cell': '23.7', 'Committed oligodendrocyte precursor': '20.7', 'Ependymal cell': '25.9', 'Oligodendrocyte': '19.6', 'Oligodendrocyte precursor cell': '19.8', 'Endothelial cell': '19.7', 'Pericyte': '30.3', 'Vascular associated smooth muscle cell': '26.0', 'Fibroblast': '27.7', 'Leukocyte': '27.9', 'Basophil': '46.1', 'Eosinophil': '4.6', 'Neutrophil': '14.7', 'Classical monocyte': '28.3', 'Non-classical monocyte': '36.7', 'Intermediate monocyte': '58.7', 'T-reg': '49.6', 'GdT-cell': '12.9', 'MAIT T-cell': '71.4', 'Memory CD4 T-cell': '8.8', 'Naive CD4 T-cell': '40.6', 'Memory CD8 T-cell': '9.7', 'Naive CD8 T-cell': '36.0', 'Memory B-cell': '6.8', 'Naive B-cell': '30.1', 'Plasmacytoid DC': '89.6', 'Myeloid DC': '57.5', 'NK-cell': '53.7', 'Total PBMC': '49.1', 'Vd2 gdTCR': '63.9', 'Memory CD4 T-cell Th1\\/Th17': '34.5', 'Memory CD4 T-cell Th17': '39.8', 'Memory CD4 T-cell Th2': '38.0', 'Non-Vd2 gdTCR': '75.6', 'Memory CD4 T-cell Th1': '38.6', 'Memory CD4 T-cell TFH': '49.4', 'Terminal effector memory CD4 T-cell': '67.3', 'Central memory CD8 T-cell': '53.5', 'Effector memory CD8 T-cell': '71.0', 'Terminal effector memory CD8 T-cell': '74.8', 'Non-switched memory B-cell': '61.3', 'Plasmablast': '97.4', 'Switched memory B-cell': '65.1', 'Exhausted memory B-cell': '62.8', 'Progenitor cell': '62.2', 'Memory T-reg': '53.4', 'Naive CD4 T-cell activated': '180.5', 'Naive CD8 T-cell activated': '155.8', 'Naive T-reg': '53.1'}
null
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
73.43619
0.707051
1,424
O60260
P42566
16862145
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
EPS15
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
Homo sapiens
Cytoplasm, Cell membrane, Membrane, clathrin-coated pit, Early endosome membrane
Low tissue specificity
{'Ciliated cells': '28.1', 'Basal respiratory cells': '16.8', 'Club cells': '28.6', 'Ionocytes': '18.0', 'Mucus glandular cells': '34.9', 'Serous glandular cells': '46.1', 'Gastric mucus-secreting cells': '35.4', 'Proximal enterocytes': '19.5', 'Paneth cells': '23.2', 'Distal enterocytes': '31.2', 'Intestinal goblet cells': '31.1', 'Exocrine glandular cells': '-0.628', 'Basal prostatic cells': '42.7', 'Prostatic glandular cells': '52.7', 'Breast glandular cells': '0.265', 'Breast myoepithelial cells': '0.309', 'Glandular and luminal cells': '30.7', 'Secretory cells': '23.6', 'Basal keratinocytes': '30.9', 'Suprabasal keratinocytes': '40.0', 'Basal squamous epithelial cells': '30.4', 'Squamous epithelial cells': '33.3', 'Alveolar cells type 1': '0.294', 'Alveolar cells type 2': '-0.366', 'Salivary duct cells': '25.6', 'Ductal cells': '0.645', 'Hepatocytes': '0.427', 'Cholangiocytes': '26.7', 'Proximal tubular cells': '0.167', 'Distal tubular cells': '24.6', 'Collecting duct cells': '42.8', 'Mesothelial cells': '0.362', 'Sertoli cells': '0.038', 'Granulosa cells': '20.9', 'Enteroendocrine cells': '28.5', 'Pancreatic endocrine cells': '11.9', 'Leydig cells': '0.087', 'Excitatory neurons': '74.4', 'Inhibitory neurons': '58.0', 'Cone photoreceptor cells': '23.8', 'Rod photoreceptor cells': '24.8', 'Bipolar cells': '14.4', 'Horizontal cells': '27.7', 'Astrocytes': '135.0', 'Oligodendrocyte precursor cells': '27.8', 'Oligodendrocytes': '292.4', 'Microglial cells': '105.6', 'Muller glia cells': '31.0', 'Schwann cells': '0.070', 'Spermatogonia': '0.413', 'Spermatocytes': '0.651', 'Early spermatids': '0.461', 'Late spermatids': '-0.043', 'Oocytes': '17.6', 'Cytotrophoblasts': '22.5', 'Syncytiotrophoblasts': '30.8', 'Extravillous trophoblasts': '19.3', 'Endothelial cells': '42.4', 'Lymphatic endothelial cells': '76.5', 'Cardiomyocytes': '0.633', 'Skeletal myocytes': '0.046', 'Smooth muscle cells': '38.7', 'Adipocytes': '49.4', 'Melanocytes': '0.103', 'Fibroblasts': '55.5', 'Peritubular cells': '0.153', 'Endometrial stromal cells': '46.1', 'Ovarian stromal cells': '24.0', 'Undifferentiated cells': '18.0', 'T-cells': '75.3', 'B-cells': '74.0', 'Plasma cells': '63.0', 'Nk-cells': '59.3', 'Granulocytes': '55.6', 'Monocytes': '79.8', 'Macrophages': '76.7', 'Hofbauer cells': '82.0', 'Kupffer cells': '73.9', 'Dendritic cells': '56.8', 'Langerhans cells': '0.129', 'Erythroid cells': '0.027', 'Adipocytes (Subcutaneous)': '-0.042', 'Adipocytes (Visceral)': '-0.278', 'Breast glandular cells (progenitors)': '0.183', 'Adipocytes (Breast)': '-0.175', 'Colon enterocytes': '-0.177', 'Colon enteroendocrine cells': '0.403', 'Enteric glia cells': '0.396', 'Mitotic cells (Colon)': '-0.025', 'Mitotic cells (Heart)': '0.474', 'Podocytes': '0.121', 'Ascending Loop of Henle cells': '0.383', 'Intercalated cells': '0.092', 'Cholangiocyte': '0.366', 'NK-cells (Liver)': '-0.174', 'Respiratory ciliated cells': '0.073', 'Mitotic cells (Lung)': '-0.147', 'NK-cells (Lung)': '0.413', 'B-cells (Lung)': '0.235', 'Alpha cells': '0.439', 'Beta cells': '0.276', 'Prostate glandular cells': '-0.210', 'Prostate basal glandular cells': '-0.133', 'Urothelial cells': '-0.025', 'Keratinocyte (other)': '0.091', 'Keratinocyte (granular)': '-0.008', 'Hair cortex cells': '-0.102', 'Inner root sheath cells': '-0.017', 'Outer root sheath cells': '-0.020', 'Sebaceous gland cells': '-0.040', 'Eccrine sweat gland cells': '0.058', 'Adipocytes (Skin)': '0.001', 'Mitotic cells (Skin)': '0.116', 'Parietal cells': '-0.592', 'Chief cells': '-0.570', 'Gastric mucous cells': '-0.426', 'Gastric enteroendocrine cells': '-0.400', 'Mitotic cells (Stomach)': '-0.047', 'Parafollicular cells': '0.059', 'Thyroid glandular cells': '0.222', 'Mitotic cells (Thyroid)': '0.209', 'Adrenal cortex cells': '0.583', 'Adrenal medulla cells': '-0.069', 'Mitotic cells (Adrenal gland)': '0.281', 'Minor salivary glandular cells': '0.401', 'Minor salivary gland ductal cells': '0.128', 'Minor salivary gland basal cells': '0.398', 'Mitotic cells (Minor salivary gland)': '0.415', 'Adipocytes (Minor salivary gland)': '0.260', 'Somatotropes': '-0.420', 'Lactotropes': '-0.124', 'Gonadotropes': '0.038', 'Corticotropes': '0.323', 'Thyrotropes': '0.332', 'Undifferentiated cells (Pituitary gland)': '0.273', 'Mitotic cells (Spleen)': '-0.236', 'Platelets': '-0.188', 'Erythrocytes': '-0.111', 'Hematopoietic stem cells': '-0.279', 'B-cells (Spleen)': '0.303', 'NK-cells (Spleen)': '0.360', 'Amygdala excitatory': '70.0', 'Cerebellar inhibitory': '143.4', 'Cge interneuron': '86.6', 'Deep-layer corticothalamic and 6b': '105.7', 'Deep-layer intratelencephalic': '100.2', 'Deep-layer near-projecting': '154.5', 'Eccentric medium spiny neuron': '47.9', 'Hippocampal ca1-3': '118.1', 'Hippocampal ca4': '227.4', 'Hippocampal dentate gyrus': '50.3', 'Lamp5-lhx6 and chandelier': '94.1', 'Lower rhombic lip': '156.6', 'Mammillary body': '117.2', 'Medium spiny neuron': '51.9', 'Mge interneuron': '84.2', 'Midbrain-derived inhibitory': '136.8', 'Miscellaneous': '76.8', 'Splatter': '80.4', 'Thalamic excitatory': '151.2', 'Upper rhombic lip': '81.1', 'Upper-layer intratelencephalic': '70.1', 'Astrocyte': '289.4', 'Bergmann glia': '381.1', 'Central nervous system macrophage': '284.8', 'Choroid plexus epithelial cell': '193.3', 'Committed oligodendrocyte precursor': '213.6', 'Ependymal cell': '175.9', 'Oligodendrocyte': '456.5', 'Oligodendrocyte precursor cell': '50.9', 'Endothelial cell': '235.5', 'Pericyte': '226.1', 'Vascular associated smooth muscle cell': '229.4', 'Fibroblast': '255.9', 'Leukocyte': '380.5', 'Basophil': '107.1', 'Eosinophil': '7.2', 'Neutrophil': '90.7', 'Classical monocyte': '49.6', 'Non-classical monocyte': '77.4', 'Intermediate monocyte': '79.5', 'T-reg': '58.7', 'GdT-cell': '5.8', 'MAIT T-cell': '88.8', 'Memory CD4 T-cell': '6.3', 'Naive CD4 T-cell': '52.8', 'Memory CD8 T-cell': '8.9', 'Naive CD8 T-cell': '41.6', 'Memory B-cell': '9.8', 'Naive B-cell': '75.8', 'Plasmacytoid DC': '72.5', 'Myeloid DC': '53.9', 'NK-cell': '69.0', 'Total PBMC': '62.8', 'Vd2 gdTCR': '67.0', 'Memory CD4 T-cell Th1\\/Th17': '83.9', 'Memory CD4 T-cell Th17': '74.3', 'Memory CD4 T-cell Th2': '70.0', 'Non-Vd2 gdTCR': '98.7', 'Memory CD4 T-cell Th1': '73.1', 'Memory CD4 T-cell TFH': '65.2', 'Terminal effector memory CD4 T-cell': '123.6', 'Central memory CD8 T-cell': '85.6', 'Effector memory CD8 T-cell': '113.6', 'Terminal effector memory CD8 T-cell': '119.3', 'Non-switched memory B-cell': '90.2', 'Plasmablast': '89.4', 'Switched memory B-cell': '111.8', 'Exhausted memory B-cell': '106.7', 'Progenitor cell': '64.5', 'Memory T-reg': '80.7', 'Naive CD4 T-cell activated': '27.8', 'Naive CD8 T-cell activated': '31.4', 'Naive T-reg': '57.2'}
1C07, 1EH2, 1F8H, 1FF1, 2IV9, 2JXC, 4RH5, 4RH9, 4RHG, 4S0G, 5AWT, 5AWU, 5JP2
{'Adipose Tissue': 42.8265622923588, 'Adrenal Gland': 40.604786821705424, 'Bladder': 33.013333333333335, 'Blood': 27.36608503767492, 'Blood Vessel': 50.21630711610487, 'Brain': 40.34111468584406, 'Breast': 38.342244008714594, 'Cervix Uteri': 47.98157894736842, 'Colon': 29.45359948652118, 'Esophagus': 27.195384083044985, 'Fallopian Tube': 40.26444444444444, 'Heart': 15.772191986062715, 'Kidney': 16.997415730337078, 'Liver': 9.87733185840708, 'Lung': 44.00965397923875, 'Muscle': 27.20817683686177, 'Nerve': 56.47327948303715, 'Ovary': 42.94427777777778, 'Pancreas': 8.897780487804878, 'Pituitary': 29.684593639575972, 'Prostate': 35.22767346938776, 'Salivary Gland': 23.182098765432094, 'Skin': 36.88782697622996, 'Small Intestine': 29.591390374331553, 'Spleen': 38.6056846473029, 'Stomach': 21.7284791086351, 'Testis': 48.09692520775624, 'Thyroid': 39.37453292496171, 'Uterus': 50.24021126760563, 'Vagina': 43.341987179487184}
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0.46, 0.59, 0.5, 0.58, 0.59, 0.53, 0.52, 0.56, 0.62, 0.55, 0.36, 0.67, 0.64, 0.53, 0.47, 0.51, 0.71, 0.56, 0.47, 0.44, 0.49, 0.56, 0.55, 0.61, 0.47, 0.72, 0.73, 0.76, 0.89, 0.79]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
67.543672
0.639018
654
O60260
P45880
33082525, 23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
VDAC2
MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA
Homo sapiens
Mitochondrion outer membrane, Membrane
Low tissue specificity
{'Ciliated cells': '144.9', 'Basal respiratory cells': '526.6', 'Club cells': '223.6', 'Ionocytes': '254.4', 'Mucus glandular cells': '115.6', 'Serous glandular cells': '228.1', 'Gastric mucus-secreting cells': '163.3', 'Proximal enterocytes': '614.4', 'Paneth cells': '287.5', 'Distal enterocytes': '634.1', 'Intestinal goblet cells': '250.8', 'Exocrine glandular cells': '-0.659', 'Basal prostatic cells': '181.4', 'Prostatic glandular cells': '95.3', 'Breast glandular cells': '-0.038', 'Breast myoepithelial cells': '-0.101', 'Glandular and luminal cells': '202.2', 'Secretory cells': '275.6', 'Basal keratinocytes': '396.8', 'Suprabasal keratinocytes': '548.7', 'Basal squamous epithelial cells': '350.1', 'Squamous epithelial cells': '505.6', 'Alveolar cells type 1': '0.176', 'Alveolar cells type 2': '-0.184', 'Salivary duct cells': '175.0', 'Ductal cells': '0.459', 'Hepatocytes': '0.397', 'Cholangiocytes': '137.4', 'Proximal tubular cells': '0.183', 'Distal tubular cells': '421.1', 'Collecting duct cells': '134.2', 'Mesothelial cells': '0.132', 'Sertoli cells': '0.027', 'Granulosa cells': '234.8', 'Enteroendocrine cells': '212.3', 'Pancreatic endocrine cells': '448.3', 'Leydig cells': '-0.015', 'Excitatory neurons': '21.4', 'Inhibitory neurons': '29.4', 'Cone photoreceptor cells': '282.1', 'Rod photoreceptor cells': '116.5', 'Bipolar cells': '144.6', 'Horizontal cells': '85.6', 'Astrocytes': '28.8', 'Oligodendrocyte precursor cells': '21.7', 'Oligodendrocytes': '24.1', 'Microglial cells': '16.1', 'Muller glia cells': '249.2', 'Schwann cells': '0.043', 'Spermatogonia': '0.274', 'Spermatocytes': '0.440', 'Early spermatids': '0.567', 'Late spermatids': '0.062', 'Oocytes': '169.1', 'Cytotrophoblasts': '334.2', 'Syncytiotrophoblasts': '399.4', 'Extravillous trophoblasts': '470.9', 'Endothelial cells': '139.1', 'Lymphatic endothelial cells': '136.6', 'Cardiomyocytes': '0.760', 'Skeletal myocytes': '0.019', 'Smooth muscle cells': '198.3', 'Adipocytes': '123.9', 'Melanocytes': '0.173', 'Fibroblasts': '163.1', 'Peritubular cells': '-0.019', 'Endometrial stromal cells': '107.0', 'Ovarian stromal cells': '247.0', 'Undifferentiated cells': '318.1', 'T-cells': '121.6', 'B-cells': '114.8', 'Plasma cells': '188.1', 'Nk-cells': '104.5', 'Granulocytes': '177.3', 'Monocytes': '256.1', 'Macrophages': '160.8', 'Hofbauer cells': '258.7', 'Kupffer cells': '140.9', 'Dendritic cells': '132.3', 'Langerhans cells': '0.065', 'Erythroid cells': '-0.045', 'Adipocytes (Subcutaneous)': '0.087', 'Adipocytes (Visceral)': '0.152', 'Breast glandular cells (progenitors)': '-0.060', 'Adipocytes (Breast)': '0.190', 'Colon enterocytes': '-0.270', 'Colon enteroendocrine cells': '0.149', 'Enteric glia cells': '-0.170', 'Mitotic cells (Colon)': '-0.218', 'Mitotic cells (Heart)': '0.452', 'Podocytes': '0.088', 'Ascending Loop of Henle cells': '0.453', 'Intercalated cells': '0.142', 'Cholangiocyte': '0.420', 'NK-cells (Liver)': '-0.418', 'Respiratory ciliated cells': '0.009', 'Mitotic cells (Lung)': '-0.075', 'NK-cells (Lung)': '-0.022', 'B-cells (Lung)': '-0.152', 'Alpha cells': '0.233', 'Beta cells': '0.084', 'Prostate glandular cells': '-0.292', 'Prostate basal glandular cells': '0.007', 'Urothelial cells': '0.013', 'Keratinocyte (other)': '0.268', 'Keratinocyte (granular)': '-0.104', 'Hair cortex cells': '0.054', 'Inner root sheath cells': '0.144', 'Outer root sheath cells': '0.132', 'Sebaceous gland cells': '-0.011', 'Eccrine sweat gland cells': '-0.069', 'Adipocytes (Skin)': '-0.140', 'Mitotic cells (Skin)': '0.277', 'Parietal cells': '-0.496', 'Chief cells': '-0.423', 'Gastric mucous cells': '-0.291', 'Gastric enteroendocrine cells': '-0.409', 'Mitotic cells (Stomach)': '0.065', 'Parafollicular cells': '0.053', 'Thyroid glandular cells': '0.451', 'Mitotic cells (Thyroid)': '-0.051', 'Adrenal cortex cells': '0.510', 'Adrenal medulla cells': '0.069', 'Mitotic cells (Adrenal gland)': '0.404', 'Minor salivary glandular cells': '0.054', 'Minor salivary gland ductal cells': '-0.297', 'Minor salivary gland basal cells': '0.660', 'Mitotic cells (Minor salivary gland)': '0.675', 'Adipocytes (Minor salivary gland)': '0.217', 'Somatotropes': '-0.083', 'Lactotropes': '0.019', 'Gonadotropes': '-0.025', 'Corticotropes': '0.063', 'Thyrotropes': '0.257', 'Undifferentiated cells (Pituitary gland)': '0.214', 'Mitotic cells (Spleen)': '-0.135', 'Platelets': '-0.122', 'Erythrocytes': '-0.089', 'Hematopoietic stem cells': '-0.123', 'B-cells (Spleen)': '0.144', 'NK-cells (Spleen)': '0.104', 'Amygdala excitatory': '18.1', 'Cerebellar inhibitory': '64.3', 'Cge interneuron': '39.4', 'Deep-layer corticothalamic and 6b': '23.9', 'Deep-layer intratelencephalic': '22.0', 'Deep-layer near-projecting': '29.5', 'Eccentric medium spiny neuron': '21.5', 'Hippocampal ca1-3': '20.6', 'Hippocampal ca4': '30.4', 'Hippocampal dentate gyrus': '28.3', 'Lamp5-lhx6 and chandelier': '41.7', 'Lower rhombic lip': '43.5', 'Mammillary body': '36.4', 'Medium spiny neuron': '19.8', 'Mge interneuron': '31.8', 'Midbrain-derived inhibitory': '39.3', 'Miscellaneous': '30.5', 'Splatter': '38.2', 'Thalamic excitatory': '34.0', 'Upper rhombic lip': '51.6', 'Upper-layer intratelencephalic': '23.0', 'Astrocyte': '25.9', 'Bergmann glia': '49.9', 'Central nervous system macrophage': '35.2', 'Choroid plexus epithelial cell': '41.0', 'Committed oligodendrocyte precursor': '31.0', 'Ependymal cell': '27.8', 'Oligodendrocyte': '32.1', 'Oligodendrocyte precursor cell': '35.6', 'Endothelial cell': '44.3', 'Pericyte': '66.1', 'Vascular associated smooth muscle cell': '48.4', 'Fibroblast': '30.6', 'Leukocyte': '27.3', 'Basophil': '120.7', 'Eosinophil': '134.1', 'Neutrophil': '85.9', 'Classical monocyte': '80.5', 'Non-classical monocyte': '83.2', 'Intermediate monocyte': '283.9', 'T-reg': '196.2', 'GdT-cell': '103.5', 'MAIT T-cell': '203.3', 'Memory CD4 T-cell': '139.9', 'Naive CD4 T-cell': '62.7', 'Memory CD8 T-cell': '115.5', 'Naive CD8 T-cell': '54.5', 'Memory B-cell': '150.2', 'Naive B-cell': '41.4', 'Plasmacytoid DC': '222.7', 'Myeloid DC': '298.7', 'NK-cell': '58.1', 'Total PBMC': '249.5', 'Vd2 gdTCR': '189.0', 'Memory CD4 T-cell Th1\\/Th17': '66.4', 'Memory CD4 T-cell Th17': '62.5', 'Memory CD4 T-cell Th2': '63.1', 'Non-Vd2 gdTCR': '186.2', 'Memory CD4 T-cell Th1': '56.1', 'Memory CD4 T-cell TFH': '48.3', 'Terminal effector memory CD4 T-cell': '173.0', 'Central memory CD8 T-cell': '178.0', 'Effector memory CD8 T-cell': '204.9', 'Terminal effector memory CD8 T-cell': '179.0', 'Non-switched memory B-cell': '189.1', 'Plasmablast': '292.8', 'Switched memory B-cell': '203.3', 'Exhausted memory B-cell': '169.6', 'Progenitor cell': '208.3', 'Memory T-reg': '47.5', 'Naive CD4 T-cell activated': '105.1', 'Naive CD8 T-cell activated': '101.1', 'Naive T-reg': '56.0'}
null
{'Adipose Tissue': 98.08798172757474, 'Adrenal Gland': 89.60577519379845, 'Bladder': 135.78142857142856, 'Blood': 55.323006458557586, 'Blood Vessel': 128.66316853932582, 'Brain': 65.70960370931112, 'Breast': 90.04237472766884, 'Cervix Uteri': 121.4121052631579, 'Colon': 136.12247753530167, 'Esophagus': 160.5505051903114, 'Fallopian Tube': 114.15555555555557, 'Heart': 119.84253077816491, 'Kidney': 65.34629213483146, 'Liver': 28.272061946902653, 'Lung': 96.6884429065744, 'Muscle': 169.80429638854298, 'Nerve': 99.2965266558966, 'Ovary': 121.3446111111111, 'Pancreas': 47.35585365853658, 'Pituitary': 69.97667844522968, 'Prostate': 81.28208163265306, 'Salivary Gland': 98.12061728395062, 'Skin': 127.86974018794912, 'Small Intestine': 85.43620320855615, 'Spleen': 57.54253112033195, 'Stomach': 92.00027855153203, 'Testis': 87.54772853185595, 'Thyroid': 86.0552833078101, 'Uterus': 113.60267605633804, 'Vagina': 167.68166666666667}
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[35.2, 33.82, 34.78, 36.39, 33.99, 34.49, 35.07, 31.88, 42.07, 49.02, 50.93, 59.01, 83.1, 92.12, 94.67, 95.27, 96.11, 96.67, 94.99, 95.73, 95.21, 94.37, 95.87, 94.94, 96.0, 96.17, 96.89, 97.02, 96.88, 96.06, 95.23, 93.6, 95.55, 94.31, 95.07, 95.09, 96.19, 97.43, 97.39, 97.92, 97.75, 98.21, 97.83, 97.12, 95.86, 93.15, 88.95, 88.33, 90.47, 95.64, 97.28, 97.68, 97.83, 97.74, 97.12, 96.9, 95.62, 95.84, 94.13, 90.44, 89.1, 91.44, 90.3, 92.51, 94.17, 94.57, 96.6, 97.17, 97.71, 98.02, 97.71, 97.71, 96.23, 93.53, 90.97, 86.06, 86.85, 89.94, 90.45, 95.01, 96.77, 97.26, 97.88, 97.83, 97.26, 96.68, 94.52, 93.55, 88.98, 91.2, 93.38, 96.11, 96.06, 97.4, 97.54, 97.33, 97.32, 96.17, 94.97, 91.53, 88.2, 87.66, 89.28, 90.87, 91.59, 96.04, 97.17, 97.38, 97.41, 96.8, 95.54, 94.78, 93.27, 93.14, 92.3, 89.86, 88.7, 87.8, 86.26, 87.73, 89.92, 90.26, 92.83, 95.05, 96.4, 96.94, 97.1, 97.17, 96.96, 95.6, 93.11, 92.42, 92.55, 95.8, 97.69, 97.8, 97.41, 97.4, 95.72, 95.46, 90.6, 86.26, 74.5, 70.58, 74.09, 79.96, 90.03, 93.13, 95.68, 96.38, 97.81, 98.15, 98.2, 98.16, 97.03, 95.78, 93.62, 90.6, 91.39, 95.69, 96.8, 97.72, 98.13, 98.26, 97.93, 97.4, 96.65, 95.25, 92.88, 90.28, 88.97, 89.82, 90.9, 93.79, 93.05, 93.8, 95.34, 96.57, 98.07, 97.86, 97.93, 97.59, 96.55, 95.7, 92.35, 89.65, 84.32, 89.79, 93.96, 95.49, 96.75, 97.22, 97.65, 97.17, 97.12, 95.89, 94.56, 91.87, 93.42, 95.0, 96.63, 96.56, 97.1, 97.43, 97.53, 97.72, 97.28, 96.17, 94.92, 92.92, 92.5, 95.85, 97.09, 97.19, 97.8, 97.73, 97.87, 96.78, 96.48, 95.63, 95.07, 94.05, 89.25, 87.54, 88.29, 82.56, 86.81, 93.62, 93.27, 96.35, 97.6, 98.02, 98.31, 98.2, 98.09, 97.92, 97.28, 95.81, 94.91, 94.2, 95.99, 97.48, 97.8, 98.07, 98.1, 98.31, 97.91, 97.71, 95.61, 93.76, 91.91, 93.36, 95.42, 96.97, 97.85, 98.17, 98.3, 98.29, 98.16, 98.15, 97.85, 96.36, 95.5, 95.06, 95.0, 97.69, 97.76, 98.11, 98.25, 98.21, 97.95, 97.32, 97.15, 96.22, 94.36, 90.98, 89.92, 88.52, 86.3, 88.16, 83.89, 83.98, 84.39, 92.75, 95.19, 95.75, 97.24, 97.81, 97.79, 97.83, 97.89, 97.78, 95.67, 89.72]
[0.97, 0.93, 0.92, 0.92, 0.79, 0.89, 0.88, 0.83, 0.83, 0.74, 0.86, 0.55, 0.65, 0.59, 0.07, 0.3, 0.32, 0.12, 0.63, 0.41, 0.08, 0.13, 0.39, 0.21, 0.04, 0.44, 0.23, 0.1, 0.18, 0.63, 0.58, 0.25, 0.16, 0.23, 0.21, 0.01, 0.36, 0.44, 0.37, 0.45, 0.2, 0.29, 0.53, 0.38, 0.62, 0.35, 0.99, 0.69, 0.28, 0.17, 0.26, 0.37, 0.28, 0.44, 0.24, 0.3, 0.23, 0.32, 0.3, 0.53, 0.64, 0.75, 0.57, 0.57, 0.7, 0.36, 0.23, 0.42, 0.41, 0.28, 0.29, 0.27, 0.44, 0.45, 0.43, 0.72, 0.86, 0.55, 0.18, 0.2, 0.25, 0.35, 0.02, 0.5, 0.41, 0.52, 0.38, 0.54, 0.56, 0.38, 0.24, 0.39, 0.16, 0.31, 0.27, 0.34, 0.06, 0.35, 0.45, 0.53, 0.55, 0.69, 0.4, 0.64, 0.18, 0.22, 0.35, 0.35, 0.11, 0.49, 0.13, 0.33, 0.4, 0.38, 0.24, 0.47, 0.73, 0.75, 0.47, 0.56, 0.62, 0.3, 0.2, 0.34, 0.44, 0.37, 0.29, 0.24, 0.3, 0.45, 0.35, 0.64, 0.19, 0.24, 0.06, 0.38, 0.24, 0.44, 0.3, 0.24, 0.23, 0.44, 0.52, 0.84, 0.71, 0.39, 0.34, 0.22, 0.41, 0.27, 0.19, 0.29, 0.21, 0.0, 0.53, 0.16, 0.73, 0.69, 0.31, 0.6, 0.17, 0.44, 0.08, 0.29, 0.24, 0.42, 0.07, 0.41, 0.16, 0.32, 0.63, 0.62, 0.66, 0.51, 0.45, 0.42, 0.5, 0.26, 0.06, 0.52, 0.07, 0.5, 0.07, 0.25, 0.61, 0.31, 0.93, 0.54, 0.44, 0.28, 0.43, 0.16, 0.43, 0.25, 0.31, 0.23, 0.47, 0.5, 0.44, 0.48, 0.37, 0.19, 0.28, 0.1, 0.47, 0.16, 0.49, 0.43, 0.5, 0.49, 0.86, 0.44, 0.28, 0.21, 0.25, 0.01, 0.39, 0.44, 0.53, 0.27, 0.38, 0.18, 0.4, 0.87, 0.68, 0.68, 0.35, 0.49, 0.51, 0.41, 0.05, 0.43, 0.02, 0.29, 0.35, 0.47, 0.31, 0.49, 0.49, 0.91, 0.41, 0.01, 0.08, 0.43, 0.05, 0.41, 0.23, 0.45, 0.41, 0.51, 0.46, 0.36, 0.31, 0.43, 0.01, 0.42, 0.08, 0.42, 0.1, 0.2, 0.39, 0.59, 0.75, 0.96, 0.36, 0.15, 0.33, 0.28, 0.1, 0.46, 0.06, 0.25, 0.19, 0.38, 0.24, 0.34, 0.69, 0.36, 0.6, 0.99, 0.81, 0.3, 0.64, 0.44, 0.35, 0.69, 0.04, 0.41, 0.17, 0.27, 0.37, 0.32, 0.68, 0.64]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
92.219864
0.398537
2,404
O60260
P45974
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
USP5
MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVERHFNKTGQRVYLHLRRTRRPKEEDPATGTGDPPRKKPTRLAIGVEGGFDLSEEKFELDEDVKIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSASRKQEVQAWDGEVRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGVPLKPLFGPGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKKRQAEEEKMALPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGTGLQPGEEELPDIAPPLVTPDEPKGSLGFYGNEDEDSFCSPHFSSPTSPMLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLILPGSSGPGSTSAAADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHIDDLDAEAAMDISEGRSAADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKVCASEKPPKDLGYIYFYQRVAS
Homo sapiens
null
Low tissue specificity
{'Ciliated cells': '10.7', 'Basal respiratory cells': '17.2', 'Club cells': '14.8', 'Ionocytes': '11.8', 'Mucus glandular cells': '9.4', 'Serous glandular cells': '20.4', 'Gastric mucus-secreting cells': '12.4', 'Proximal enterocytes': '19.4', 'Paneth cells': '13.3', 'Distal enterocytes': '21.1', 'Intestinal goblet cells': '18.4', 'Exocrine glandular cells': '-0.628', 'Basal prostatic cells': '10.9', 'Prostatic glandular cells': '23.0', 'Breast glandular cells': '0.195', 'Breast myoepithelial cells': '0.055', 'Glandular and luminal cells': '13.8', 'Secretory cells': '10.3', 'Basal keratinocytes': '25.4', 'Suprabasal keratinocytes': '34.3', 'Basal squamous epithelial cells': '9.3', 'Squamous epithelial cells': '18.5', 'Alveolar cells type 1': '-0.134', 'Alveolar cells type 2': '0.225', 'Salivary duct cells': '9.0', 'Ductal cells': '0.630', 'Hepatocytes': '0.587', 'Cholangiocytes': '24.8', 'Proximal tubular cells': '0.227', 'Distal tubular cells': '12.3', 'Collecting duct cells': '25.3', 'Mesothelial cells': '0.187', 'Sertoli cells': '-0.049', 'Granulosa cells': '11.4', 'Enteroendocrine cells': '18.6', 'Pancreatic endocrine cells': '25.5', 'Leydig cells': '-0.127', 'Excitatory neurons': '11.1', 'Inhibitory neurons': '11.4', 'Cone photoreceptor cells': '25.5', 'Rod photoreceptor cells': '15.7', 'Bipolar cells': '20.5', 'Horizontal cells': '23.9', 'Astrocytes': '7.1', 'Oligodendrocyte precursor cells': '5.7', 'Oligodendrocytes': '11.1', 'Microglial cells': '8.9', 'Muller glia cells': '15.0', 'Schwann cells': '0.013', 'Spermatogonia': '0.161', 'Spermatocytes': '0.361', 'Early spermatids': '0.474', 'Late spermatids': '0.181', 'Oocytes': '13.2', 'Cytotrophoblasts': '45.5', 'Syncytiotrophoblasts': '54.9', 'Extravillous trophoblasts': '29.2', 'Endothelial cells': '14.4', 'Lymphatic endothelial cells': '16.2', 'Cardiomyocytes': '0.704', 'Skeletal myocytes': '-0.301', 'Smooth muscle cells': '17.1', 'Adipocytes': '11.1', 'Melanocytes': '0.374', 'Fibroblasts': '16.2', 'Peritubular cells': '-0.197', 'Endometrial stromal cells': '13.4', 'Ovarian stromal cells': '12.0', 'Undifferentiated cells': '26.3', 'T-cells': '15.2', 'B-cells': '12.5', 'Plasma cells': '15.7', 'Nk-cells': '11.0', 'Granulocytes': '14.0', 'Monocytes': '9.8', 'Macrophages': '12.6', 'Hofbauer cells': '23.2', 'Kupffer cells': '11.0', 'Dendritic cells': '15.9', 'Langerhans cells': '0.339', 'Erythroid cells': '-0.142', 'Adipocytes (Subcutaneous)': '0.236', 'Adipocytes (Visceral)': '0.264', 'Breast glandular cells (progenitors)': '0.071', 'Adipocytes (Breast)': '0.141', 'Colon enterocytes': '-0.117', 'Colon enteroendocrine cells': '0.116', 'Enteric glia cells': '-0.252', 'Mitotic cells (Colon)': '-0.145', 'Mitotic cells (Heart)': '0.491', 'Podocytes': '-0.184', 'Ascending Loop of Henle cells': '0.491', 'Intercalated cells': '-0.036', 'Cholangiocyte': '0.258', 'NK-cells (Liver)': '-0.351', 'Respiratory ciliated cells': '-0.065', 'Mitotic cells (Lung)': '0.262', 'NK-cells (Lung)': '-0.245', 'B-cells (Lung)': '-0.271', 'Alpha cells': '0.426', 'Beta cells': '0.289', 'Prostate glandular cells': '0.114', 'Prostate basal glandular cells': '0.150', 'Urothelial cells': '-0.058', 'Keratinocyte (other)': '0.609', 'Keratinocyte (granular)': '0.224', 'Hair cortex cells': '-0.044', 'Inner root sheath cells': '-0.041', 'Outer root sheath cells': '-0.090', 'Sebaceous gland cells': '-0.057', 'Eccrine sweat gland cells': '-0.479', 'Adipocytes (Skin)': '-0.381', 'Mitotic cells (Skin)': '0.307', 'Parietal cells': '-0.565', 'Chief cells': '-0.573', 'Gastric mucous cells': '-0.278', 'Gastric enteroendocrine cells': '-0.454', 'Mitotic cells (Stomach)': '0.208', 'Parafollicular cells': '0.101', 'Thyroid glandular cells': '0.393', 'Mitotic cells (Thyroid)': '-0.057', 'Adrenal cortex cells': '0.461', 'Adrenal medulla cells': '0.039', 'Mitotic cells (Adrenal gland)': '0.381', 'Minor salivary glandular cells': '0.158', 'Minor salivary gland ductal cells': '-0.296', 'Minor salivary gland basal cells': '0.659', 'Mitotic cells (Minor salivary gland)': '0.774', 'Adipocytes (Minor salivary gland)': '0.245', 'Somatotropes': '0.194', 'Lactotropes': '0.069', 'Gonadotropes': '0.003', 'Corticotropes': '0.214', 'Thyrotropes': '0.147', 'Undifferentiated cells (Pituitary gland)': '-0.031', 'Mitotic cells (Spleen)': '-0.047', 'Platelets': '0.002', 'Erythrocytes': '-0.057', 'Hematopoietic stem cells': '-0.120', 'B-cells (Spleen)': '0.282', 'NK-cells (Spleen)': '0.078', 'Amygdala excitatory': '19.4', 'Cerebellar inhibitory': '20.6', 'Cge interneuron': '23.7', 'Deep-layer corticothalamic and 6b': '19.7', 'Deep-layer intratelencephalic': '21.6', 'Deep-layer near-projecting': '24.5', 'Eccentric medium spiny neuron': '21.2', 'Hippocampal ca1-3': '19.2', 'Hippocampal ca4': '21.6', 'Hippocampal dentate gyrus': '16.2', 'Lamp5-lhx6 and chandelier': '25.9', 'Lower rhombic lip': '19.6', 'Mammillary body': '17.6', 'Medium spiny neuron': '17.5', 'Mge interneuron': '20.1', 'Midbrain-derived inhibitory': '19.7', 'Miscellaneous': '19.7', 'Splatter': '22.4', 'Thalamic excitatory': '30.4', 'Upper rhombic lip': '13.7', 'Upper-layer intratelencephalic': '18.4', 'Astrocyte': '13.8', 'Bergmann glia': '15.2', 'Central nervous system macrophage': '9.7', 'Choroid plexus epithelial cell': '6.5', 'Committed oligodendrocyte precursor': '20.7', 'Ependymal cell': '9.8', 'Oligodendrocyte': '20.7', 'Oligodendrocyte precursor cell': '14.0', 'Endothelial cell': '12.2', 'Pericyte': '14.9', 'Vascular associated smooth muscle cell': '14.4', 'Fibroblast': '11.7', 'Leukocyte': '14.0', 'Basophil': '10.0', 'Eosinophil': '8.3', 'Neutrophil': '1.8', 'Classical monocyte': '34.4', 'Non-classical monocyte': '41.8', 'Intermediate monocyte': '59.9', 'T-reg': '62.3', 'GdT-cell': '24.4', 'MAIT T-cell': '57.3', 'Memory CD4 T-cell': '21.8', 'Naive CD4 T-cell': '67.6', 'Memory CD8 T-cell': '20.8', 'Naive CD8 T-cell': '75.8', 'Memory B-cell': '15.1', 'Naive B-cell': '26.4', 'Plasmacytoid DC': '94.9', 'Myeloid DC': '71.7', 'NK-cell': '64.6', 'Total PBMC': '54.8', 'Vd2 gdTCR': '63.6', 'Memory CD4 T-cell Th1\\/Th17': '58.4', 'Memory CD4 T-cell Th17': '89.4', 'Memory CD4 T-cell Th2': '85.7', 'Non-Vd2 gdTCR': '70.9', 'Memory CD4 T-cell Th1': '77.1', 'Memory CD4 T-cell TFH': '104.1', 'Terminal effector memory CD4 T-cell': '54.8', 'Central memory CD8 T-cell': '69.6', 'Effector memory CD8 T-cell': '67.6', 'Terminal effector memory CD8 T-cell': '68.2', 'Non-switched memory B-cell': '65.1', 'Plasmablast': '81.7', 'Switched memory B-cell': '58.5', 'Exhausted memory B-cell': '56.2', 'Progenitor cell': '67.2', 'Memory T-reg': '96.1', 'Naive CD4 T-cell activated': '41.4', 'Naive CD8 T-cell activated': '53.9', 'Naive T-reg': '75.4'}
2DAG, 2DAK, 2G43, 2G45, 3IHP, 6DXH, 6DXT, 6NFT, 6P9G, 7MS5, 7MS6, 7MS7
{'Adipose Tissue': 42.32282392026578, 'Adrenal Gland': 69.43356589147287, 'Bladder': 69.66619047619048, 'Blood': 24.89395866523143, 'Blood Vessel': 75.33397752808989, 'Brain': 54.43386790310371, 'Breast': 42.7559477124183, 'Cervix Uteri': 60.17368421052631, 'Colon': 51.57318356867779, 'Esophagus': 59.69758269896194, 'Fallopian Tube': 60.32888888888889, 'Heart': 25.23332171893147, 'Kidney': 29.457292134831462, 'Liver': 23.37032300884956, 'Lung': 44.32024221453287, 'Muscle': 58.00564134495641, 'Nerve': 68.18399030694668, 'Ovary': 48.81422222222222, 'Pancreas': 14.596057926829268, 'Pituitary': 70.73098939929328, 'Prostate': 54.87763265306123, 'Salivary Gland': 35.437901234567896, 'Skin': 76.09693200663351, 'Small Intestine': 44.863315508021394, 'Spleen': 45.234813278008296, 'Stomach': 39.38373259052925, 'Testis': 125.9135457063712, 'Thyroid': 58.28433384379785, 'Uterus': 70.59387323943662, 'Vagina': 57.06153846153846}
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57.22, 58.19, 61.7, 51.34, 53.34, 53.52, 54.24, 45.85, 50.21, 46.8, 46.39, 45.67, 43.92, 50.48, 54.51, 63.38, 65.4, 64.1, 69.25, 71.3, 72.54, 73.48, 64.8, 64.1, 71.33, 75.19, 84.95, 89.77, 90.48, 92.24, 93.12, 93.12, 95.48, 95.18, 96.47, 95.83, 93.7, 93.68, 86.34, 80.16, 75.56, 66.08, 74.08, 82.22, 86.66, 90.8, 95.61, 95.41, 97.03, 98.56, 98.24, 98.22, 98.57, 98.4, 98.43, 98.2, 98.3, 97.54, 97.54, 98.15, 98.02, 97.74, 97.12, 97.91, 97.6, 97.43, 96.21, 96.32, 96.19, 95.77, 96.0, 96.26, 94.33, 93.48, 94.58, 93.73, 91.25, 93.41, 95.61, 93.51, 92.65, 95.04, 95.77, 96.65, 97.22, 97.99, 98.1, 97.95, 97.95, 97.9, 97.6, 97.55, 96.34, 97.03, 97.43, 94.36, 91.08, 89.09, 90.32, 91.1, 85.2, 75.82, 66.01, 55.54, 46.3, 44.66, 35.22, 33.53, 34.42, 33.87, 30.88, 34.17, 32.67, 37.58, 40.23, 48.05, 56.01, 63.37, 78.37, 76.69, 87.93, 93.62, 91.51, 93.55, 87.44, 91.74, 95.64, 92.12, 89.22, 93.99, 94.1, 90.86, 89.03, 80.79, 87.29, 80.21, 80.9, 87.71, 81.84, 74.5, 71.82, 66.84, 74.24, 82.65, 90.46, 94.27, 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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
80.475455
0.374476
704
O60260
P46527
25591737
UbiBrowser
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
CDKN1B
MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT
Homo sapiens
Nucleus, Cytoplasm, Endosome
Low tissue specificity
{'Ciliated cells': '25.5', 'Basal respiratory cells': '19.8', 'Club cells': '33.9', 'Ionocytes': '17.3', 'Mucus glandular cells': '26.7', 'Serous glandular cells': '25.5', 'Gastric mucus-secreting cells': '21.2', 'Proximal enterocytes': '32.3', 'Paneth cells': '26.7', 'Distal enterocytes': '26.4', 'Intestinal goblet cells': '43.2', 'Exocrine glandular cells': '-0.402', 'Basal prostatic cells': '53.1', 'Prostatic glandular cells': '52.2', 'Breast glandular cells': '0.569', 'Breast myoepithelial cells': '0.552', 'Glandular and luminal cells': '35.5', 'Secretory cells': '17.9', 'Basal keratinocytes': '48.9', 'Suprabasal keratinocytes': '45.4', 'Basal squamous epithelial cells': '108.4', 'Squamous epithelial cells': '94.2', 'Alveolar cells type 1': '0.268', 'Alveolar cells type 2': '-0.454', 'Salivary duct cells': '18.6', 'Ductal cells': '0.390', 'Hepatocytes': '0.427', 'Cholangiocytes': '24.8', 'Proximal tubular cells': '0.182', 'Distal tubular cells': '12.3', 'Collecting duct cells': '7.8', 'Mesothelial cells': '0.360', 'Sertoli cells': '0.710', 'Granulosa cells': '34.9', 'Enteroendocrine cells': '46.9', 'Pancreatic endocrine cells': '10.2', 'Leydig cells': '0.570', 'Excitatory neurons': '7.8', 'Inhibitory neurons': '12.8', 'Cone photoreceptor cells': '37.4', 'Rod photoreceptor cells': '22.9', 'Bipolar cells': '40.5', 'Horizontal cells': '33.4', 'Astrocytes': '5.9', 'Oligodendrocyte precursor cells': '5.7', 'Oligodendrocytes': '27.4', 'Microglial cells': '22.4', 'Muller glia cells': '161.0', 'Schwann cells': '0.203', 'Spermatogonia': '0.605', 'Spermatocytes': '0.208', 'Early spermatids': '-0.390', 'Late spermatids': '-0.600', 'Oocytes': '34.6', 'Cytotrophoblasts': '42.9', 'Syncytiotrophoblasts': '39.3', 'Extravillous trophoblasts': '47.9', 'Endothelial cells': '48.3', 'Lymphatic endothelial cells': '35.6', 'Cardiomyocytes': '0.591', 'Skeletal myocytes': '0.056', 'Smooth muscle cells': '59.7', 'Adipocytes': '59.8', 'Melanocytes': '0.231', 'Fibroblasts': '42.7', 'Peritubular cells': '0.470', 'Endometrial stromal cells': '35.7', 'Ovarian stromal cells': '41.7', 'Undifferentiated cells': '47.6', 'T-cells': '190.6', 'B-cells': '126.4', 'Plasma cells': '104.9', 'Nk-cells': '112.4', 'Granulocytes': '60.0', 'Monocytes': '214.6', 'Macrophages': '64.1', 'Hofbauer cells': '29.4', 'Kupffer cells': '45.2', 'Dendritic cells': '34.0', 'Langerhans cells': '0.223', 'Erythroid cells': '0.094', 'Adipocytes (Subcutaneous)': '-0.517', 'Adipocytes (Visceral)': '-0.477', 'Breast glandular cells (progenitors)': '0.368', 'Adipocytes (Breast)': '-0.627', 'Colon enterocytes': '-0.181', 'Colon enteroendocrine cells': '0.273', 'Enteric glia cells': '0.274', 'Mitotic cells (Colon)': '-0.154', 'Mitotic cells (Heart)': '0.432', 'Podocytes': '0.231', 'Ascending Loop of Henle cells': '0.387', 'Intercalated cells': '0.157', 'Cholangiocyte': '0.289', 'NK-cells (Liver)': '-0.151', 'Respiratory ciliated cells': '0.124', 'Mitotic cells (Lung)': '-0.198', 'NK-cells (Lung)': '0.460', 'B-cells (Lung)': '0.301', 'Alpha cells': '0.322', 'Beta cells': '0.167', 'Prostate glandular cells': '-0.143', 'Prostate basal glandular cells': '-0.077', 'Urothelial cells': '-0.007', 'Keratinocyte (other)': '0.422', 'Keratinocyte (granular)': '-0.212', 'Hair cortex cells': '-0.070', 'Inner root sheath cells': '0.013', 'Outer root sheath cells': '0.228', 'Sebaceous gland cells': '-0.068', 'Eccrine sweat gland cells': '0.016', 'Adipocytes (Skin)': '-0.310', 'Mitotic cells (Skin)': '0.433', 'Parietal cells': '-0.533', 'Chief cells': '-0.430', 'Gastric mucous cells': '-0.374', 'Gastric enteroendocrine cells': '-0.297', 'Mitotic cells (Stomach)': '-0.041', 'Parafollicular cells': '0.037', 'Thyroid glandular cells': '0.270', 'Mitotic cells (Thyroid)': '0.117', 'Adrenal cortex cells': '0.464', 'Adrenal medulla cells': '0.086', 'Mitotic cells (Adrenal gland)': '0.262', 'Minor salivary glandular cells': '0.329', 'Minor salivary gland ductal cells': '0.195', 'Minor salivary gland basal cells': '0.233', 'Mitotic cells (Minor salivary gland)': '0.325', 'Adipocytes (Minor salivary gland)': '0.264', 'Somatotropes': '-0.125', 'Lactotropes': '-0.147', 'Gonadotropes': '0.003', 'Corticotropes': '-0.198', 'Thyrotropes': '0.077', 'Undifferentiated cells (Pituitary gland)': '0.405', 'Mitotic cells (Spleen)': '-0.100', 'Platelets': '-0.172', 'Erythrocytes': '-0.125', 'Hematopoietic stem cells': '-0.154', 'B-cells (Spleen)': '0.316', 'NK-cells (Spleen)': '0.264', 'Amygdala excitatory': '7.2', 'Cerebellar inhibitory': '17.8', 'Cge interneuron': '24.8', 'Deep-layer corticothalamic and 6b': '7.4', 'Deep-layer intratelencephalic': '8.1', 'Deep-layer near-projecting': '6.0', 'Eccentric medium spiny neuron': '7.2', 'Hippocampal ca1-3': '6.8', 'Hippocampal ca4': '7.4', 'Hippocampal dentate gyrus': '7.4', 'Lamp5-lhx6 and chandelier': '21.3', 'Lower rhombic lip': '16.1', 'Mammillary body': '17.5', 'Medium spiny neuron': '7.2', 'Mge interneuron': '18.5', 'Midbrain-derived inhibitory': '21.4', 'Miscellaneous': '8.8', 'Splatter': '14.0', 'Thalamic excitatory': '13.8', 'Upper rhombic lip': '38.3', 'Upper-layer intratelencephalic': '7.4', 'Astrocyte': '10.5', 'Bergmann glia': '20.7', 'Central nervous system macrophage': '22.7', 'Choroid plexus epithelial cell': '13.8', 'Committed oligodendrocyte precursor': '20.0', 'Ependymal cell': '19.3', 'Oligodendrocyte': '39.1', 'Oligodendrocyte precursor cell': '18.7', 'Endothelial cell': '55.0', 'Pericyte': '61.5', 'Vascular associated smooth muscle cell': '58.1', 'Fibroblast': '28.4', 'Leukocyte': '63.4', 'Basophil': '146.3', 'Eosinophil': '8.2', 'Neutrophil': '108.3', 'Classical monocyte': '115.3', 'Non-classical monocyte': '165.4', 'Intermediate monocyte': '55.0', 'T-reg': '96.6', 'GdT-cell': '5.8', 'MAIT T-cell': '112.3', 'Memory CD4 T-cell': '7.5', 'Naive CD4 T-cell': '437.3', 'Memory CD8 T-cell': '6.9', 'Naive CD8 T-cell': '336.0', 'Memory B-cell': '6.7', 'Naive B-cell': '180.8', 'Plasmacytoid DC': '17.6', 'Myeloid DC': '69.7', 'NK-cell': '141.8', 'Total PBMC': '64.5', 'Vd2 gdTCR': '53.3', 'Memory CD4 T-cell Th1\\/Th17': '454.5', 'Memory CD4 T-cell Th17': '375.9', 'Memory CD4 T-cell Th2': '438.1', 'Non-Vd2 gdTCR': '73.3', 'Memory CD4 T-cell Th1': '377.8', 'Memory CD4 T-cell TFH': '436.6', 'Terminal effector memory CD4 T-cell': '50.5', 'Central memory CD8 T-cell': '100.1', 'Effector memory CD8 T-cell': '58.9', 'Terminal effector memory CD8 T-cell': '54.5', 'Non-switched memory B-cell': '46.9', 'Plasmablast': '53.8', 'Switched memory B-cell': '50.0', 'Exhausted memory B-cell': '46.7', 'Progenitor cell': '20.4', 'Memory T-reg': '447.2', 'Naive CD4 T-cell activated': '97.4', 'Naive CD8 T-cell activated': '93.6', 'Naive T-reg': '713.8'}
1H27, 1JSU, 2AST, 5UQ3, 6ATH, 6P8E, 6P8F, 6P8G, 7B5L, 7B5M, 7B5R, 7OR8, 7ORG, 7ORH, 7ORS, 7ORT, 8BYA, 8BYL, 8BZO
{'Adipose Tissue': 89.28307308970099, 'Adrenal Gland': 49.201007751937986, 'Bladder': 63.78047619047619, 'Blood': 68.55482454251884, 'Blood Vessel': 122.23632958801498, 'Brain': 69.23933762301286, 'Breast': 97.70257080610024, 'Cervix Uteri': 117.59052631578946, 'Colon': 69.30115532734274, 'Esophagus': 56.005737024221446, 'Fallopian Tube': 110.25333333333332, 'Heart': 23.158851335656216, 'Kidney': 27.414337078651688, 'Liver': 24.55152654867257, 'Lung': 82.52216262975779, 'Muscle': 43.84146575342466, 'Nerve': 139.4383198707593, 'Ovary': 106.24844444444444, 'Pancreas': 16.517003048780488, 'Pituitary': 49.177385159010605, 'Prostate': 57.263387755102045, 'Salivary Gland': 48.443765432098765, 'Skin': 63.90882808181316, 'Small Intestine': 65.75898395721926, 'Spleen': 75.991244813278, 'Stomach': 39.69147632311978, 'Testis': 51.55265927977839, 'Thyroid': 78.49858499234303, 'Uterus': 118.09823943661972, 'Vagina': 94.36891025641025}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
69.051313
0.809899
2,742
O60260
P46937
32863938
UbiBrowser
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
YAP1
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL
Homo sapiens
Cytoplasm, Nucleus, Cell junction, tight junction
Low tissue specificity
{'Ciliated cells': '47.2', 'Basal respiratory cells': '41.8', 'Club cells': '41.2', 'Ionocytes': '30.6', 'Mucus glandular cells': '55.6', 'Serous glandular cells': '30.7', 'Gastric mucus-secreting cells': '24.2', 'Proximal enterocytes': '23.3', 'Paneth cells': '12.5', 'Distal enterocytes': '19.8', 'Intestinal goblet cells': '12.5', 'Exocrine glandular cells': '-0.624', 'Basal prostatic cells': '75.5', 'Prostatic glandular cells': '36.3', 'Breast glandular cells': '0.343', 'Breast myoepithelial cells': '0.532', 'Glandular and luminal cells': '75.2', 'Secretory cells': '44.5', 'Basal keratinocytes': '89.6', 'Suprabasal keratinocytes': '100.8', 'Basal squamous epithelial cells': '65.6', 'Squamous epithelial cells': '56.0', 'Alveolar cells type 1': '0.263', 'Alveolar cells type 2': '-0.196', 'Salivary duct cells': '59.5', 'Ductal cells': '0.696', 'Hepatocytes': '0.333', 'Cholangiocytes': '57.2', 'Proximal tubular cells': '0.162', 'Distal tubular cells': '3.1', 'Collecting duct cells': '87.5', 'Mesothelial cells': '0.390', 'Sertoli cells': '0.635', 'Granulosa cells': '62.4', 'Enteroendocrine cells': '11.3', 'Pancreatic endocrine cells': '13.6', 'Leydig cells': '0.665', 'Excitatory neurons': '1.5', 'Inhibitory neurons': '1.6', 'Cone photoreceptor cells': '0.0', 'Rod photoreceptor cells': '1.0', 'Bipolar cells': '0.2', 'Horizontal cells': '0.0', 'Astrocytes': '137.8', 'Oligodendrocyte precursor cells': '4.7', 'Oligodendrocytes': '0.7', 'Microglial cells': '57.3', 'Muller glia cells': '26.6', 'Schwann cells': '0.106', 'Spermatogonia': '0.559', 'Spermatocytes': '0.123', 'Early spermatids': '-0.500', 'Late spermatids': '-0.700', 'Oocytes': '8.8', 'Cytotrophoblasts': '89.5', 'Syncytiotrophoblasts': '65.5', 'Extravillous trophoblasts': '16.4', 'Endothelial cells': '28.7', 'Lymphatic endothelial cells': '34.8', 'Cardiomyocytes': '0.583', 'Skeletal myocytes': '0.290', 'Smooth muscle cells': '67.3', 'Adipocytes': '26.3', 'Melanocytes': '0.191', 'Fibroblasts': '41.5', 'Peritubular cells': '0.639', 'Endometrial stromal cells': '48.3', 'Ovarian stromal cells': '43.2', 'Undifferentiated cells': '27.9', 'T-cells': '2.9', 'B-cells': '1.6', 'Plasma cells': '2.0', 'Nk-cells': '0.1', 'Granulocytes': '5.5', 'Monocytes': '0.4', 'Macrophages': '3.4', 'Hofbauer cells': '3.6', 'Kupffer cells': '2.9', 'Dendritic cells': '0.0', 'Langerhans cells': '0.151', 'Erythroid cells': '-0.079', 'Adipocytes (Subcutaneous)': '-0.202', 'Adipocytes (Visceral)': '-0.240', 'Breast glandular cells (progenitors)': '0.270', 'Adipocytes (Breast)': '-0.376', 'Colon enterocytes': '-0.124', 'Colon enteroendocrine cells': '0.236', 'Enteric glia cells': '-0.224', 'Mitotic cells (Colon)': '0.010', 'Mitotic cells (Heart)': '0.494', 'Podocytes': '0.039', 'Ascending Loop of Henle cells': '0.381', 'Intercalated cells': '0.013', 'Cholangiocyte': '0.339', 'NK-cells (Liver)': '-0.284', 'Respiratory ciliated cells': '0.020', 'Mitotic cells (Lung)': '-0.147', 'NK-cells (Lung)': '0.236', 'B-cells (Lung)': '0.039', 'Alpha cells': '0.430', 'Beta cells': '0.243', 'Prostate glandular cells': '-0.449', 'Prostate basal glandular cells': '-0.030', 'Urothelial cells': '0.068', 'Keratinocyte (other)': '0.283', 'Keratinocyte (granular)': '-0.148', 'Hair cortex cells': '-0.061', 'Inner root sheath cells': '0.021', 'Outer root sheath cells': '0.130', 'Sebaceous gland cells': '-0.015', 'Eccrine sweat gland cells': '-0.029', 'Adipocytes (Skin)': '-0.169', 'Mitotic cells (Skin)': '0.388', 'Parietal cells': '-0.659', 'Chief cells': '-0.472', 'Gastric mucous cells': '-0.537', 'Gastric enteroendocrine cells': '-0.374', 'Mitotic cells (Stomach)': '-0.081', 'Parafollicular cells': '0.095', 'Thyroid glandular cells': '0.431', 'Mitotic cells (Thyroid)': '0.063', 'Adrenal cortex cells': '0.577', 'Adrenal medulla cells': '-0.060', 'Mitotic cells (Adrenal gland)': '0.268', 'Minor salivary glandular cells': '0.482', 'Minor salivary gland ductal cells': '0.013', 'Minor salivary gland basal cells': '0.534', 'Mitotic cells (Minor salivary gland)': '0.546', 'Adipocytes (Minor salivary gland)': '0.185', 'Somatotropes': '-0.336', 'Lactotropes': '-0.380', 'Gonadotropes': '-0.054', 'Corticotropes': '-0.326', 'Thyrotropes': '-0.089', 'Undifferentiated cells (Pituitary gland)': '0.630', 'Mitotic cells (Spleen)': '-0.264', 'Platelets': '-0.176', 'Erythrocytes': '-0.109', 'Hematopoietic stem cells': '-0.273', 'B-cells (Spleen)': '0.084', 'NK-cells (Spleen)': '0.143', 'Amygdala excitatory': '2.4', 'Cerebellar inhibitory': '2.4', 'Cge interneuron': '1.5', 'Deep-layer corticothalamic and 6b': '2.2', 'Deep-layer intratelencephalic': '1.6', 'Deep-layer near-projecting': '1.3', 'Eccentric medium spiny neuron': '1.0', 'Hippocampal ca1-3': '2.2', 'Hippocampal ca4': '2.3', 'Hippocampal dentate gyrus': '1.5', 'Lamp5-lhx6 and chandelier': '1.6', 'Lower rhombic lip': '1.8', 'Mammillary body': '1.8', 'Medium spiny neuron': '2.1', 'Mge interneuron': '1.7', 'Midbrain-derived inhibitory': '2.3', 'Miscellaneous': '1.8', 'Splatter': '4.2', 'Thalamic excitatory': '3.2', 'Upper rhombic lip': '0.7', 'Upper-layer intratelencephalic': '1.6', 'Astrocyte': '275.7', 'Bergmann glia': '354.0', 'Central nervous system macrophage': '1.7', 'Choroid plexus epithelial cell': '404.0', 'Committed oligodendrocyte precursor': '15.6', 'Ependymal cell': '371.9', 'Oligodendrocyte': '1.2', 'Oligodendrocyte precursor cell': '3.0', 'Endothelial cell': '232.3', 'Pericyte': '191.6', 'Vascular associated smooth muscle cell': '263.5', 'Fibroblast': '351.3', 'Leukocyte': '2.5', 'Basophil': '0.4', 'Eosinophil': '0.0', 'Neutrophil': '0.0', 'Classical monocyte': '0.0', 'Non-classical monocyte': '0.0', 'Intermediate monocyte': '0.0', 'T-reg': '0.0', 'GdT-cell': '0.0', 'MAIT T-cell': '0.0', 'Memory CD4 T-cell': '0.0', 'Naive CD4 T-cell': '0.1', 'Memory CD8 T-cell': '0.0', 'Naive CD8 T-cell': '0.2', 'Memory B-cell': '0.0', 'Naive B-cell': '0.1', 'Plasmacytoid DC': '0.0', 'Myeloid DC': '0.0', 'NK-cell': '0.0', 'Total PBMC': '0.0', 'Vd2 gdTCR': '0.0', 'Memory CD4 T-cell Th1\\/Th17': '0.3', 'Memory CD4 T-cell Th17': '0.3', 'Memory CD4 T-cell Th2': '0.1', 'Non-Vd2 gdTCR': '0.0', 'Memory CD4 T-cell Th1': '0.2', 'Memory CD4 T-cell TFH': '0.1', 'Terminal effector memory CD4 T-cell': '0.0', 'Central memory CD8 T-cell': '0.0', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '0.0', 'Non-switched memory B-cell': '0.0', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.0', 'Exhausted memory B-cell': '0.0', 'Progenitor cell': '0.2', 'Memory T-reg': '0.0', 'Naive CD4 T-cell activated': '0.2', 'Naive CD8 T-cell activated': '0.2', 'Naive T-reg': '0.1'}
1JMQ, 1K5R, 1K9Q, 1K9R, 2LAW, 2LAX, 2LAY, 2LTV, 2LTW, 3KYS, 3MHR, 4RE1, 4REX, 5OAQ, 5YDX, 5YDY, 6G6X, 6G8I, 6G8J, 6G8K, 6G8L, 6G8P, 6G8Q, 6GE3, 6GE4, 6GE5, 6GE6, 6GEC, 6GEE, 6GEG, 6GEI, 6GEK, 6HIK, 6HIL, 6Q2X, 7O07, 8A8Q, 8A8R, 8C2F
{'Adipose Tissue': 73.8536046511628, 'Adrenal Gland': 33.60143410852713, 'Bladder': 111.05428571428573, 'Blood': 0.2135388223896663, 'Blood Vessel': 178.68831460674156, 'Brain': 9.898443149129449, 'Breast': 66.49812636165578, 'Cervix Uteri': 113.88473684210526, 'Colon': 58.737486521181005, 'Esophagus': 79.3780276816609, 'Fallopian Tube': 97.30555555555556, 'Heart': 21.664954703832755, 'Kidney': 27.92830337078652, 'Liver': 18.31645132743363, 'Lung': 81.08551903114187, 'Muscle': 28.741813200498132, 'Nerve': 83.94423263327948, 'Ovary': 109.28972222222222, 'Pancreas': 9.944716463414634, 'Pituitary': 19.81635335689046, 'Prostate': 68.85097959183675, 'Salivary Gland': 54.89944444444444, 'Skin': 85.25377003869542, 'Small Intestine': 36.9027807486631, 'Spleen': 15.17898755186722, 'Stomach': 42.14091922005571, 'Testis': 21.02172299168975, 'Thyroid': 74.55444104134763, 'Uterus': 146.15845070422534, 'Vagina': 102.06948717948718}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
56.946964
0.77252
1,566
O60260
P46940
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
IQGAP1
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
Homo sapiens
Cell membrane, Nucleus, Cytoplasm, Apical cell membrane, Basolateral cell membrane
Low tissue specificity
{'Ciliated cells': '110.2', 'Basal respiratory cells': '87.5', 'Club cells': '127.6', 'Ionocytes': '78.4', 'Mucus glandular cells': '234.9', 'Serous glandular cells': '194.0', 'Gastric mucus-secreting cells': '81.9', 'Proximal enterocytes': '62.0', 'Paneth cells': '93.4', 'Distal enterocytes': '183.5', 'Intestinal goblet cells': '104.5', 'Exocrine glandular cells': '-0.613', 'Basal prostatic cells': '109.8', 'Prostatic glandular cells': '74.8', 'Breast glandular cells': '0.276', 'Breast myoepithelial cells': '0.465', 'Glandular and luminal cells': '231.4', 'Secretory cells': '145.2', 'Basal keratinocytes': '146.0', 'Suprabasal keratinocytes': '197.3', 'Basal squamous epithelial cells': '67.1', 'Squamous epithelial cells': '101.2', 'Alveolar cells type 1': '0.262', 'Alveolar cells type 2': '0.180', 'Salivary duct cells': '196.6', 'Ductal cells': '0.678', 'Hepatocytes': '0.412', 'Cholangiocytes': '53.4', 'Proximal tubular cells': '0.111', 'Distal tubular cells': '9.2', 'Collecting duct cells': '73.9', 'Mesothelial cells': '0.293', 'Sertoli cells': '0.476', 'Granulosa cells': '65.2', 'Enteroendocrine cells': '91.6', 'Pancreatic endocrine cells': '61.1', 'Leydig cells': '0.592', 'Excitatory neurons': '38.3', 'Inhibitory neurons': '23.3', 'Cone photoreceptor cells': '8.5', 'Rod photoreceptor cells': '33.1', 'Bipolar cells': '3.2', 'Horizontal cells': '12.0', 'Astrocytes': '34.4', 'Oligodendrocyte precursor cells': '9.0', 'Oligodendrocytes': '294.0', 'Microglial cells': '58.2', 'Muller glia cells': '20.4', 'Schwann cells': '0.097', 'Spermatogonia': '0.628', 'Spermatocytes': '0.358', 'Early spermatids': '-0.389', 'Late spermatids': '-0.611', 'Oocytes': '44.1', 'Cytotrophoblasts': '90.6', 'Syncytiotrophoblasts': '98.8', 'Extravillous trophoblasts': '162.6', 'Endothelial cells': '144.5', 'Lymphatic endothelial cells': '121.9', 'Cardiomyocytes': '0.359', 'Skeletal myocytes': '-0.241', 'Smooth muscle cells': '140.5', 'Adipocytes': '174.4', 'Melanocytes': '0.309', 'Fibroblasts': '105.0', 'Peritubular cells': '0.510', 'Endometrial stromal cells': '123.5', 'Ovarian stromal cells': '73.2', 'Undifferentiated cells': '93.7', 'T-cells': '193.9', 'B-cells': '128.2', 'Plasma cells': '121.1', 'Nk-cells': '276.4', 'Granulocytes': '202.4', 'Monocytes': '524.7', 'Macrophages': '305.9', 'Hofbauer cells': '173.3', 'Kupffer cells': '377.8', 'Dendritic cells': '158.5', 'Langerhans cells': '0.338', 'Erythroid cells': '0.043', 'Adipocytes (Subcutaneous)': '-0.381', 'Adipocytes (Visceral)': '-0.322', 'Breast glandular cells (progenitors)': '0.190', 'Adipocytes (Breast)': '-0.301', 'Colon enterocytes': '-0.105', 'Colon enteroendocrine cells': '0.160', 'Enteric glia cells': '-0.172', 'Mitotic cells (Colon)': '0.043', 'Mitotic cells (Heart)': '0.559', 'Podocytes': '-0.065', 'Ascending Loop of Henle cells': '0.421', 'Intercalated cells': '-0.038', 'Cholangiocyte': '0.509', 'NK-cells (Liver)': '-0.196', 'Respiratory ciliated cells': '-0.053', 'Mitotic cells (Lung)': '0.075', 'NK-cells (Lung)': '0.101', 'B-cells (Lung)': '-0.114', 'Alpha cells': '0.350', 'Beta cells': '0.180', 'Prostate glandular cells': '-0.433', 'Prostate basal glandular cells': '-0.044', 'Urothelial cells': '0.102', 'Keratinocyte (other)': '0.459', 'Keratinocyte (granular)': '-0.006', 'Hair cortex cells': '-0.005', 'Inner root sheath cells': '0.053', 'Outer root sheath cells': '0.163', 'Sebaceous gland cells': '-0.013', 'Eccrine sweat gland cells': '0.011', 'Adipocytes (Skin)': '-0.149', 'Mitotic cells (Skin)': '0.436', 'Parietal cells': '-0.670', 'Chief cells': '-0.601', 'Gastric mucous cells': '-0.365', 'Gastric enteroendocrine cells': '-0.445', 'Mitotic cells (Stomach)': '0.102', 'Parafollicular cells': '0.108', 'Thyroid glandular cells': '0.363', 'Mitotic cells (Thyroid)': '0.100', 'Adrenal cortex cells': '0.698', 'Adrenal medulla cells': '0.023', 'Mitotic cells (Adrenal gland)': '0.442', 'Minor salivary glandular cells': '0.481', 'Minor salivary gland ductal cells': '0.008', 'Minor salivary gland basal cells': '0.498', 'Mitotic cells (Minor salivary gland)': '0.558', 'Adipocytes (Minor salivary gland)': '0.145', 'Somatotropes': '-0.026', 'Lactotropes': '-0.198', 'Gonadotropes': '0.001', 'Corticotropes': '-0.197', 'Thyrotropes': '0.005', 'Undifferentiated cells (Pituitary gland)': '0.273', 'Mitotic cells (Spleen)': '0.017', 'Platelets': '0.148', 'Erythrocytes': '-0.082', 'Hematopoietic stem cells': '0.061', 'B-cells (Spleen)': '0.020', 'NK-cells (Spleen)': '0.156', 'Amygdala excitatory': '82.4', 'Cerebellar inhibitory': '17.9', 'Cge interneuron': '48.3', 'Deep-layer corticothalamic and 6b': '85.0', 'Deep-layer intratelencephalic': '96.1', 'Deep-layer near-projecting': '50.1', 'Eccentric medium spiny neuron': '101.8', 'Hippocampal ca1-3': '74.3', 'Hippocampal ca4': '71.9', 'Hippocampal dentate gyrus': '46.8', 'Lamp5-lhx6 and chandelier': '48.8', 'Lower rhombic lip': '101.2', 'Mammillary body': '162.7', 'Medium spiny neuron': '47.9', 'Mge interneuron': '43.1', 'Midbrain-derived inhibitory': '63.8', 'Miscellaneous': '82.2', 'Splatter': '49.5', 'Thalamic excitatory': '66.1', 'Upper rhombic lip': '53.4', 'Upper-layer intratelencephalic': '67.9', 'Astrocyte': '96.6', 'Bergmann glia': '22.2', 'Central nervous system macrophage': '49.2', 'Choroid plexus epithelial cell': '82.0', 'Committed oligodendrocyte precursor': '156.2', 'Ependymal cell': '91.5', 'Oligodendrocyte': '555.0', 'Oligodendrocyte precursor cell': '22.5', 'Endothelial cell': '398.1', 'Pericyte': '147.2', 'Vascular associated smooth muscle cell': '211.1', 'Fibroblast': '121.8', 'Leukocyte': '346.8', 'Basophil': '465.2', 'Eosinophil': '20.1', 'Neutrophil': '994.6', 'Classical monocyte': '274.5', 'Non-classical monocyte': '305.6', 'Intermediate monocyte': '338.7', 'T-reg': '123.7', 'GdT-cell': '21.8', 'MAIT T-cell': '160.5', 'Memory CD4 T-cell': '13.5', 'Naive CD4 T-cell': '75.4', 'Memory CD8 T-cell': '18.9', 'Naive CD8 T-cell': '64.9', 'Memory B-cell': '12.7', 'Naive B-cell': '125.0', 'Plasmacytoid DC': '123.9', 'Myeloid DC': '278.2', 'NK-cell': '337.4', 'Total PBMC': '189.2', 'Vd2 gdTCR': '193.9', 'Memory CD4 T-cell Th1\\/Th17': '130.4', 'Memory CD4 T-cell Th17': '117.4', 'Memory CD4 T-cell Th2': '124.2', 'Non-Vd2 gdTCR': '220.6', 'Memory CD4 T-cell Th1': '120.0', 'Memory CD4 T-cell TFH': '96.3', 'Terminal effector memory CD4 T-cell': '236.0', 'Central memory CD8 T-cell': '127.9', 'Effector memory CD8 T-cell': '212.2', 'Terminal effector memory CD8 T-cell': '239.3', 'Non-switched memory B-cell': '186.9', 'Plasmablast': '90.1', 'Switched memory B-cell': '174.1', 'Exhausted memory B-cell': '186.4', 'Progenitor cell': '64.3', 'Memory T-reg': '153.7', 'Naive CD4 T-cell activated': '61.8', 'Naive CD8 T-cell activated': '77.3', 'Naive T-reg': '88.6'}
1X0H, 2RR8, 3FAY, 3I6X, 5L0O
{'Adipose Tissue': 81.94789867109635, 'Adrenal Gland': 40.998368217054264, 'Bladder': 83.63238095238096, 'Blood': 96.53464370290637, 'Blood Vessel': 132.00652434456927, 'Brain': 12.24287547312642, 'Breast': 72.54605664488017, 'Cervix Uteri': 92.91368421052633, 'Colon': 62.90734274711168, 'Esophagus': 74.18680968858132, 'Fallopian Tube': 92.48555555555556, 'Heart': 16.25897793263647, 'Kidney': 24.87947191011236, 'Liver': 4.852884955752212, 'Lung': 93.89686851211071, 'Muscle': 21.982628891656287, 'Nerve': 70.42211631663974, 'Ovary': 61.36877777777777, 'Pancreas': 15.447667682926827, 'Pituitary': 37.873250883392224, 'Prostate': 48.533469387755105, 'Salivary Gland': 73.58166666666666, 'Skin': 101.34321171918188, 'Small Intestine': 51.24272727272727, 'Spleen': 55.820290456431536, 'Stomach': 37.450863509749304, 'Testis': 16.56965650969529, 'Thyroid': 73.60836140888209, 'Uterus': 148.63021126760563, 'Vagina': 89.26711538461538}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
78.484062
0.37513
156
O60260
P47756
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
CAPZB
MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC
Homo sapiens
Cytoplasm, cytoskeleton, Cytoplasm, myofibril, sarcomere
Low tissue specificity
{'Ciliated cells': '106.8', 'Basal respiratory cells': '246.9', 'Club cells': '137.2', 'Ionocytes': '161.2', 'Mucus glandular cells': '93.6', 'Serous glandular cells': '84.1', 'Gastric mucus-secreting cells': '113.8', 'Proximal enterocytes': '252.3', 'Paneth cells': '219.6', 'Distal enterocytes': '299.7', 'Intestinal goblet cells': '234.3', 'Exocrine glandular cells': '-0.711', 'Basal prostatic cells': '82.1', 'Prostatic glandular cells': '163.1', 'Breast glandular cells': '0.185', 'Breast myoepithelial cells': '0.178', 'Glandular and luminal cells': '110.5', 'Secretory cells': '106.0', 'Basal keratinocytes': '154.4', 'Suprabasal keratinocytes': '236.6', 'Basal squamous epithelial cells': '104.8', 'Squamous epithelial cells': '164.5', 'Alveolar cells type 1': '-0.056', 'Alveolar cells type 2': '-0.463', 'Salivary duct cells': '97.0', 'Ductal cells': '0.736', 'Hepatocytes': '0.517', 'Cholangiocytes': '116.4', 'Proximal tubular cells': '0.214', 'Distal tubular cells': '248.9', 'Collecting duct cells': '95.3', 'Mesothelial cells': '0.245', 'Sertoli cells': '-0.453', 'Granulosa cells': '111.9', 'Enteroendocrine cells': '132.0', 'Pancreatic endocrine cells': '373.6', 'Leydig cells': '-0.433', 'Excitatory neurons': '48.2', 'Inhibitory neurons': '64.7', 'Cone photoreceptor cells': '88.4', 'Rod photoreceptor cells': '97.8', 'Bipolar cells': '100.6', 'Horizontal cells': '73.0', 'Astrocytes': '50.2', 'Oligodendrocyte precursor cells': '40.1', 'Oligodendrocytes': '60.4', 'Microglial cells': '119.0', 'Muller glia cells': '150.7', 'Schwann cells': '0.104', 'Spermatogonia': '-0.218', 'Spermatocytes': '-0.005', 'Early spermatids': '0.655', 'Late spermatids': '0.762', 'Oocytes': '150.7', 'Cytotrophoblasts': '353.3', 'Syncytiotrophoblasts': '352.7', 'Extravillous trophoblasts': '436.5', 'Endothelial cells': '165.5', 'Lymphatic endothelial cells': '199.4', 'Cardiomyocytes': '0.668', 'Skeletal myocytes': '-0.093', 'Smooth muscle cells': '183.8', 'Adipocytes': '191.9', 'Melanocytes': '0.335', 'Fibroblasts': '187.8', 'Peritubular cells': '-0.352', 'Endometrial stromal cells': '132.4', 'Ovarian stromal cells': '225.0', 'Undifferentiated cells': '157.6', 'T-cells': '254.2', 'B-cells': '159.9', 'Plasma cells': '120.5', 'Nk-cells': '267.9', 'Granulocytes': '167.2', 'Monocytes': '448.2', 'Macrophages': '296.6', 'Hofbauer cells': '778.0', 'Kupffer cells': '326.6', 'Dendritic cells': '173.9', 'Langerhans cells': '0.328', 'Erythroid cells': '-0.038', 'Adipocytes (Subcutaneous)': '-0.444', 'Adipocytes (Visceral)': '-0.349', 'Breast glandular cells (progenitors)': '-0.002', 'Adipocytes (Breast)': '-0.180', 'Colon enterocytes': '-0.221', 'Colon enteroendocrine cells': '0.242', 'Enteric glia cells': '-0.156', 'Mitotic cells (Colon)': '-0.218', 'Mitotic cells (Heart)': '0.559', 'Podocytes': '0.003', 'Ascending Loop of Henle cells': '0.403', 'Intercalated cells': '0.025', 'Cholangiocyte': '0.419', 'NK-cells (Liver)': '-0.361', 'Respiratory ciliated cells': '-0.041', 'Mitotic cells (Lung)': '0.083', 'NK-cells (Lung)': '0.243', 'B-cells (Lung)': '0.103', 'Alpha cells': '0.459', 'Beta cells': '0.236', 'Prostate glandular cells': '-0.091', 'Prostate basal glandular cells': '-0.078', 'Urothelial cells': '-0.140', 'Keratinocyte (other)': '0.489', 'Keratinocyte (granular)': '-0.109', 'Hair cortex cells': '0.028', 'Inner root sheath cells': '0.110', 'Outer root sheath cells': '0.200', 'Sebaceous gland cells': '-0.120', 'Eccrine sweat gland cells': '-0.182', 'Adipocytes (Skin)': '-0.323', 'Mitotic cells (Skin)': '0.370', 'Parietal cells': '-0.734', 'Chief cells': '-0.670', 'Gastric mucous cells': '-0.361', 'Gastric enteroendocrine cells': '-0.503', 'Mitotic cells (Stomach)': '0.093', 'Parafollicular cells': '0.156', 'Thyroid glandular cells': '0.452', 'Mitotic cells (Thyroid)': '0.111', 'Adrenal cortex cells': '0.589', 'Adrenal medulla cells': '0.117', 'Mitotic cells (Adrenal gland)': '0.381', 'Minor salivary glandular cells': '0.231', 'Minor salivary gland ductal cells': '-0.283', 'Minor salivary gland basal cells': '0.699', 'Mitotic cells (Minor salivary gland)': '0.808', 'Adipocytes (Minor salivary gland)': '0.289', 'Somatotropes': '-0.162', 'Lactotropes': '-0.169', 'Gonadotropes': '0.009', 'Corticotropes': '-0.173', 'Thyrotropes': '0.225', 'Undifferentiated cells (Pituitary gland)': '0.374', 'Mitotic cells (Spleen)': '-0.191', 'Platelets': '0.002', 'Erythrocytes': '-0.155', 'Hematopoietic stem cells': '0.013', 'B-cells (Spleen)': '0.096', 'NK-cells (Spleen)': '0.106', 'Amygdala excitatory': '116.0', 'Cerebellar inhibitory': '143.5', 'Cge interneuron': '124.2', 'Deep-layer corticothalamic and 6b': '119.3', 'Deep-layer intratelencephalic': '115.4', 'Deep-layer near-projecting': '109.0', 'Eccentric medium spiny neuron': '82.8', 'Hippocampal ca1-3': '123.4', 'Hippocampal ca4': '154.2', 'Hippocampal dentate gyrus': '119.0', 'Lamp5-lhx6 and chandelier': '131.4', 'Lower rhombic lip': '89.9', 'Mammillary body': '90.6', 'Medium spiny neuron': '80.0', 'Mge interneuron': '135.3', 'Midbrain-derived inhibitory': '98.1', 'Miscellaneous': '114.3', 'Splatter': '95.7', 'Thalamic excitatory': '90.8', 'Upper rhombic lip': '80.1', 'Upper-layer intratelencephalic': '111.5', 'Astrocyte': '115.7', 'Bergmann glia': '93.6', 'Central nervous system macrophage': '696.6', 'Choroid plexus epithelial cell': '110.6', 'Committed oligodendrocyte precursor': '113.8', 'Ependymal cell': '101.1', 'Oligodendrocyte': '134.8', 'Oligodendrocyte precursor cell': '96.2', 'Endothelial cell': '141.8', 'Pericyte': '234.3', 'Vascular associated smooth muscle cell': '204.5', 'Fibroblast': '223.7', 'Leukocyte': '329.1', 'Basophil': '334.0', 'Eosinophil': '1078.9', 'Neutrophil': '690.9', 'Classical monocyte': '295.6', 'Non-classical monocyte': '530.1', 'Intermediate monocyte': '532.3', 'T-reg': '306.5', 'GdT-cell': '304.6', 'MAIT T-cell': '301.0', 'Memory CD4 T-cell': '319.3', 'Naive CD4 T-cell': '213.7', 'Memory CD8 T-cell': '329.2', 'Naive CD8 T-cell': '226.3', 'Memory B-cell': '266.9', 'Naive B-cell': '83.9', 'Plasmacytoid DC': '280.5', 'Myeloid DC': '368.7', 'NK-cell': '324.7', 'Total PBMC': '400.0', 'Vd2 gdTCR': '330.0', 'Memory CD4 T-cell Th1\\/Th17': '218.9', 'Memory CD4 T-cell Th17': '309.1', 'Memory CD4 T-cell Th2': '293.9', 'Non-Vd2 gdTCR': '352.4', 'Memory CD4 T-cell Th1': '260.6', 'Memory CD4 T-cell TFH': '326.4', 'Terminal effector memory CD4 T-cell': '349.5', 'Central memory CD8 T-cell': '292.0', 'Effector memory CD8 T-cell': '364.0', 'Terminal effector memory CD8 T-cell': '349.7', 'Non-switched memory B-cell': '250.8', 'Plasmablast': '232.1', 'Switched memory B-cell': '315.1', 'Exhausted memory B-cell': '292.9', 'Progenitor cell': '144.5', 'Memory T-reg': '373.7', 'Naive CD4 T-cell activated': '188.7', 'Naive CD8 T-cell activated': '256.7', 'Naive T-reg': '170.0'}
8F8Q
{'Adipose Tissue': 152.23308139534885, 'Adrenal Gland': 117.69317829457364, 'Bladder': 197.14761904761903, 'Blood': 229.92766415500537, 'Blood Vessel': 241.41531835205993, 'Brain': 79.50700605601817, 'Breast': 147.1051416122004, 'Cervix Uteri': 215.3421052631579, 'Colon': 204.83037227214376, 'Esophagus': 198.92045674740484, 'Fallopian Tube': 195.07777777777775, 'Heart': 75.94128919860627, 'Kidney': 78.77921348314607, 'Liver': 40.321473451327435, 'Lung': 190.1949480968858, 'Muscle': 118.67265255292652, 'Nerve': 157.4924394184168, 'Ovary': 187.8705555555555, 'Pancreas': 28.68883231707317, 'Pituitary': 102.94106007067138, 'Prostate': 185.65942857142855, 'Salivary Gland': 100.25796296296296, 'Skin': 164.72781094527363, 'Small Intestine': 159.7973796791444, 'Spleen': 157.78684647302904, 'Stomach': 120.0565181058496, 'Testis': 208.4711911357341, 'Thyroid': 148.67085758039818, 'Uterus': 226.8352112676056, 'Vagina': 191.71410256410255}
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[52.84, 77.13, 84.93, 92.38, 92.26, 91.18, 92.91, 94.34, 92.77, 91.05, 93.28, 93.8, 90.08, 88.63, 90.97, 91.13, 85.96, 83.74, 80.04, 85.93, 86.21, 86.44, 91.62, 91.97, 91.08, 92.09, 94.76, 93.11, 92.33, 94.26, 94.51, 92.91, 92.97, 93.17, 91.08, 87.92, 85.79, 87.92, 88.19, 85.27, 83.65, 85.11, 85.09, 81.79, 84.09, 88.08, 93.39, 92.47, 95.23, 96.05, 96.69, 96.26, 94.86, 94.41, 95.16, 95.0, 95.8, 97.51, 97.97, 97.73, 95.31, 91.47, 88.37, 91.05, 94.26, 92.96, 91.19, 88.67, 89.92, 94.14, 96.61, 97.37, 97.71, 97.64, 97.07, 96.02, 96.36, 95.75, 96.57, 95.21, 95.35, 94.14, 92.39, 86.04, 88.48, 88.33, 92.12, 94.1, 95.52, 96.09, 95.54, 94.13, 96.0, 97.54, 96.85, 95.69, 98.02, 97.93, 96.8, 97.72, 98.1, 97.18, 97.11, 97.72, 97.04, 97.0, 97.57, 96.66, 96.14, 96.61, 96.08, 94.25, 93.17, 92.31, 94.34, 96.85, 97.73, 98.2, 98.42, 98.01, 97.71, 96.15, 95.27, 94.65, 90.87, 91.2, 94.48, 96.69, 97.16, 96.87, 97.22, 98.17, 97.8, 97.53, 96.38, 94.98, 90.17, 84.15, 74.95, 64.9, 71.04, 66.99, 77.86, 81.77, 87.5, 88.41, 91.68, 94.16, 94.76, 95.94, 96.67, 97.4, 96.66, 97.58, 97.54, 97.25, 95.83, 92.4, 89.88, 82.92, 81.69, 80.12, 88.27, 93.61, 95.88, 96.92, 97.44, 97.81, 97.56, 96.35, 96.1, 93.69, 94.03, 91.04, 90.65, 86.63, 88.06, 87.55, 87.38, 87.35, 87.65, 84.43, 87.32, 86.77, 90.54, 88.64, 87.01, 87.63, 85.25, 85.14, 84.0, 87.8, 90.05, 91.31, 93.6, 94.61, 94.82, 96.23, 95.68, 95.28, 95.07, 94.67, 94.33, 91.63, 86.63, 87.76, 90.29, 93.73, 95.14, 95.54, 95.86, 96.25, 96.96, 96.8, 96.19, 96.06, 97.35, 96.85, 96.36, 95.25, 94.1, 94.73, 95.1, 94.71, 92.55, 93.87, 92.53, 89.8, 89.76, 91.25, 88.78, 85.61, 86.57, 89.82, 88.6, 87.68, 88.87, 90.03, 91.3, 90.26, 88.32, 86.9, 89.99, 85.09, 80.55, 80.98, 75.86, 64.69, 67.64, 58.9, 56.69, 63.94, 65.31, 73.02, 73.1, 75.56, 84.21, 83.82, 82.63, 86.88, 89.5, 88.46, 88.4, 88.97, 89.14, 86.67, 83.62, 81.06, 75.96, 67.72, 64.76, 59.05, 59.63, 51.93, 51.83, 56.02, 44.06]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
89.628664
0.407076
2,480
O60260
P48449
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
LSS
MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDTKNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGHP
Homo sapiens
Endoplasmic reticulum membrane
Low tissue specificity
{'Ciliated cells': '9.0', 'Basal respiratory cells': '31.6', 'Club cells': '18.1', 'Ionocytes': '49.3', 'Mucus glandular cells': '7.4', 'Serous glandular cells': '8.3', 'Gastric mucus-secreting cells': '17.7', 'Proximal enterocytes': '4.3', 'Paneth cells': '3.4', 'Distal enterocytes': '18.3', 'Intestinal goblet cells': '9.9', 'Exocrine glandular cells': '-0.451', 'Basal prostatic cells': '8.8', 'Prostatic glandular cells': '21.6', 'Breast glandular cells': '-0.164', 'Breast myoepithelial cells': '-0.372', 'Glandular and luminal cells': '12.2', 'Secretory cells': '3.4', 'Basal keratinocytes': '30.7', 'Suprabasal keratinocytes': '55.1', 'Basal squamous epithelial cells': '7.3', 'Squamous epithelial cells': '13.2', 'Alveolar cells type 1': '-0.005', 'Alveolar cells type 2': '0.541', 'Salivary duct cells': '7.8', 'Ductal cells': '0.543', 'Hepatocytes': '0.499', 'Cholangiocytes': '19.1', 'Proximal tubular cells': '0.181', 'Distal tubular cells': '0.0', 'Collecting duct cells': '9.7', 'Mesothelial cells': '0.070', 'Sertoli cells': '0.435', 'Granulosa cells': '9.4', 'Enteroendocrine cells': '13.7', 'Pancreatic endocrine cells': '1.7', 'Leydig cells': '0.476', 'Excitatory neurons': '20.5', 'Inhibitory neurons': '23.1', 'Cone photoreceptor cells': '5.1', 'Rod photoreceptor cells': '10.5', 'Bipolar cells': '18.0', 'Horizontal cells': '42.2', 'Astrocytes': '63.2', 'Oligodendrocyte precursor cells': '20.8', 'Oligodendrocytes': '147.8', 'Microglial cells': '20.6', 'Muller glia cells': '7.7', 'Schwann cells': '0.007', 'Spermatogonia': '0.360', 'Spermatocytes': '0.215', 'Early spermatids': '-0.428', 'Late spermatids': '-0.534', 'Oocytes': '22.8', 'Cytotrophoblasts': '3.6', 'Syncytiotrophoblasts': '8.3', 'Extravillous trophoblasts': '6.6', 'Endothelial cells': '16.6', 'Lymphatic endothelial cells': '9.9', 'Cardiomyocytes': '0.658', 'Skeletal myocytes': '0.070', 'Smooth muscle cells': '10.3', 'Adipocytes': '12.9', 'Melanocytes': '-0.101', 'Fibroblasts': '14.7', 'Peritubular cells': '0.441', 'Endometrial stromal cells': '14.9', 'Ovarian stromal cells': '14.1', 'Undifferentiated cells': '7.7', 'T-cells': '7.3', 'B-cells': '5.5', 'Plasma cells': '12.6', 'Nk-cells': '7.9', 'Granulocytes': '2.9', 'Monocytes': '5.6', 'Macrophages': '6.1', 'Hofbauer cells': '8.1', 'Kupffer cells': '54.3', 'Dendritic cells': '11.5', 'Langerhans cells': '0.004', 'Erythroid cells': '0.118', 'Adipocytes (Subcutaneous)': '0.592', 'Adipocytes (Visceral)': '0.379', 'Breast glandular cells (progenitors)': '-0.187', 'Adipocytes (Breast)': '0.510', 'Colon enterocytes': '-0.004', 'Colon enteroendocrine cells': '0.203', 'Enteric glia cells': '0.123', 'Mitotic cells (Colon)': '-0.010', 'Mitotic cells (Heart)': '0.451', 'Podocytes': '-0.190', 'Ascending Loop of Henle cells': '0.514', 'Intercalated cells': '-0.043', 'Cholangiocyte': '-0.161', 'NK-cells (Liver)': '0.157', 'Respiratory ciliated cells': '-0.106', 'Mitotic cells (Lung)': '0.141', 'NK-cells (Lung)': '-0.426', 'B-cells (Lung)': '-0.344', 'Alpha cells': '0.357', 'Beta cells': '0.254', 'Prostate glandular cells': '0.618', 'Prostate basal glandular cells': '0.220', 'Urothelial cells': '-0.158', 'Keratinocyte (other)': '-0.070', 'Keratinocyte (granular)': '0.365', 'Hair cortex cells': '-0.210', 'Inner root sheath cells': '-0.280', 'Outer root sheath cells': '-0.379', 'Sebaceous gland cells': '0.045', 'Eccrine sweat gland cells': '-0.224', 'Adipocytes (Skin)': '0.080', 'Mitotic cells (Skin)': '-0.248', 'Parietal cells': '-0.493', 'Chief cells': '-0.435', 'Gastric mucous cells': '-0.164', 'Gastric enteroendocrine cells': '-0.335', 'Mitotic cells (Stomach)': '0.224', 'Parafollicular cells': '-0.014', 'Thyroid glandular cells': '0.174', 'Mitotic cells (Thyroid)': '0.040', 'Adrenal cortex cells': '0.533', 'Adrenal medulla cells': '0.115', 'Mitotic cells (Adrenal gland)': '0.249', 'Minor salivary glandular cells': '0.088', 'Minor salivary gland ductal cells': '-0.024', 'Minor salivary gland basal cells': '0.376', 'Mitotic cells (Minor salivary gland)': '0.309', 'Adipocytes (Minor salivary gland)': '0.255', 'Somatotropes': '0.183', 'Lactotropes': '0.248', 'Gonadotropes': '0.206', 'Corticotropes': '0.368', 'Thyrotropes': '0.182', 'Undifferentiated cells (Pituitary gland)': '-0.186', 'Mitotic cells (Spleen)': '-0.206', 'Platelets': '-0.045', 'Erythrocytes': '-0.037', 'Hematopoietic stem cells': '-0.188', 'B-cells (Spleen)': '0.339', 'NK-cells (Spleen)': '0.212', 'Amygdala excitatory': '28.8', 'Cerebellar inhibitory': '35.0', 'Cge interneuron': '43.0', 'Deep-layer corticothalamic and 6b': '42.3', 'Deep-layer intratelencephalic': '31.0', 'Deep-layer near-projecting': '67.3', 'Eccentric medium spiny neuron': '34.5', 'Hippocampal ca1-3': '41.2', 'Hippocampal ca4': '14.9', 'Hippocampal dentate gyrus': '13.7', 'Lamp5-lhx6 and chandelier': '41.0', 'Lower rhombic lip': '115.6', 'Mammillary body': '44.7', 'Medium spiny neuron': '45.6', 'Mge interneuron': '32.3', 'Midbrain-derived inhibitory': '78.7', 'Miscellaneous': '33.2', 'Splatter': '70.4', 'Thalamic excitatory': '81.7', 'Upper rhombic lip': '39.6', 'Upper-layer intratelencephalic': '23.7', 'Astrocyte': '82.2', 'Bergmann glia': '63.5', 'Central nervous system macrophage': '22.0', 'Choroid plexus epithelial cell': '47.1', 'Committed oligodendrocyte precursor': '146.3', 'Ependymal cell': '27.4', 'Oligodendrocyte': '270.1', 'Oligodendrocyte precursor cell': '53.5', 'Endothelial cell': '67.3', 'Pericyte': '14.4', 'Vascular associated smooth muscle cell': '26.4', 'Fibroblast': '78.6', 'Leukocyte': '31.5', 'Basophil': '12.6', 'Eosinophil': '2.2', 'Neutrophil': '1.0', 'Classical monocyte': '7.0', 'Non-classical monocyte': '9.6', 'Intermediate monocyte': '7.8', 'T-reg': '22.2', 'GdT-cell': '4.0', 'MAIT T-cell': '15.0', 'Memory CD4 T-cell': '2.9', 'Naive CD4 T-cell': '22.4', 'Memory CD8 T-cell': '4.9', 'Naive CD8 T-cell': '27.3', 'Memory B-cell': '3.1', 'Naive B-cell': '12.3', 'Plasmacytoid DC': '35.2', 'Myeloid DC': '9.0', 'NK-cell': '46.2', 'Total PBMC': '12.7', 'Vd2 gdTCR': '15.9', 'Memory CD4 T-cell Th1\\/Th17': '20.5', 'Memory CD4 T-cell Th17': '31.1', 'Memory CD4 T-cell Th2': '31.4', 'Non-Vd2 gdTCR': '31.4', 'Memory CD4 T-cell Th1': '32.3', 'Memory CD4 T-cell TFH': '43.8', 'Terminal effector memory CD4 T-cell': '31.1', 'Central memory CD8 T-cell': '20.9', 'Effector memory CD8 T-cell': '29.1', 'Terminal effector memory CD8 T-cell': '42.4', 'Non-switched memory B-cell': '20.4', 'Plasmablast': '13.2', 'Switched memory B-cell': '15.2', 'Exhausted memory B-cell': '16.3', 'Progenitor cell': '20.5', 'Memory T-reg': '39.8', 'Naive CD4 T-cell activated': '7.7', 'Naive CD8 T-cell activated': '12.1', 'Naive T-reg': '30.3'}
1W6J, 1W6K
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[0.85, 0.75, 0.97, 0.94, 0.55, 0.59, 0.49, 0.19, 0.33, 0.25, 0.09, 0.14, 0.13, 0.48, 0.63, 0.33, 0.92, 0.48, 0.52, 0.16, 0.47, 0.1, 0.35, 0.23, 0.0, 0.12, 0.07, 0.44, 0.15, 0.8, 0.59, 0.0, 0.34, 0.06, 0.19, 0.02, 0.43, 0.15, 0.19, 0.66, 0.58, 0.57, 0.93, 0.75, 0.44, 0.48, 0.9, 0.14, 0.35, 0.1, 0.13, 0.01, 0.01, 0.2, 0.12, 0.01, 0.22, 0.31, 0.7, 0.14, 0.71, 0.99, 0.46, 0.14, 0.75, 0.72, 0.21, 0.81, 0.76, 0.09, 0.64, 0.15, 0.0, 0.27, 0.39, 0.0, 0.02, 0.22, 0.1, 0.0, 0.01, 0.41, 0.01, 0.04, 0.17, 0.42, 0.05, 0.2, 0.09, 0.64, 0.18, 0.0, 0.0, 0.01, 0.11, 0.06, 0.08, 0.08, 0.01, 0.03, 0.06, 0.05, 0.05, 0.07, 0.04, 0.02, 0.0, 0.0, 0.03, 0.01, 0.0, 0.08, 0.13, 0.08, 0.08, 0.58, 0.12, 0.87, 0.23, 0.48, 0.46, 0.09, 0.01, 0.52, 0.44, 0.0, 0.0, 0.14, 0.06, 0.03, 0.0, 0.3, 0.22, 0.09, 0.06, 0.03, 0.49, 0.27, 0.0, 0.0, 0.0, 0.03, 0.08, 0.01, 0.11, 0.01, 0.14, 0.51, 0.13, 0.09, 0.0, 0.02, 0.04, 0.0, 0.0, 0.0, 0.0, 0.01, 0.0, 0.01, 0.0, 0.11, 0.2, 0.08, 0.65, 0.1, 0.48, 0.28, 0.82, 0.26, 0.69, 0.25, 0.0, 0.3, 0.34, 0.0, 0.2, 0.58, 0.13, 0.0, 0.31, 0.63, 0.31, 0.39, 0.0, 0.0, 0.06, 0.06, 0.0, 0.01, 0.23, 0.09, 0.0, 0.01, 0.01, 0.03, 0.0, 0.01, 0.0, 0.0, 0.18, 0.0, 0.03, 0.29, 0.07, 0.4, 0.0, 0.04, 0.1, 0.03, 0.2, 0.14, 0.0, 0.05, 0.21, 0.04, 0.25, 0.43, 0.48, 0.48, 0.85, 0.11, 0.81, 0.17, 0.0, 0.03, 0.1, 0.18, 0.14, 0.08, 0.0, 0.23, 0.06, 0.02, 0.07, 0.07, 0.15, 0.02, 0.0, 0.01, 0.03, 0.07, 0.0, 0.02, 0.17, 0.3, 0.3, 0.02, 0.46, 0.06, 0.64, 0.53, 0.21, 0.75, 0.21, 0.0, 0.52, 0.32, 0.0, 0.17, 0.74, 0.08, 0.0, 0.05, 0.59, 0.44, 0.64, 0.17, 0.87, 0.65, 0.07, 0.55, 0.16, 0.56, 0.61, 0.12, 0.17, 0.67, 0.33, 0.16, 0.1, 0.75, 0.94, 0.13, 0.32, 0.32, 0.25, 0.58, 0.11, 0.22, 0.75, 0.35, 0.03, 0.64, 0.52, 0.31, 0.11, 0.59, 0.63, 0.2, 0.14, 0.6, 0.29, 0.06, 0.89, 0.75, 0.38, 0.38, 0.62, 0.74, 0.41, 0.07, 0.69, 0.62, 0.0, 0.17, 0.53, 0.25, 0.0, 0.2, 0.36, 0.06, 0.0, 0.15, 0.0, 0.04, 0.03, 0.61, 0.11, 0.0, 0.45, 0.02, 0.0, 0.0, 0.04, 0.09, 0.07, 0.12, 0.01, 0.0, 0.01, 0.0, 0.02, 0.0, 0.0, 0.0, 0.07, 0.25, 0.56, 0.49, 0.38, 0.27, 0.55, 0.82, 0.18, 0.75, 0.2, 0.06, 0.5, 0.38, 0.0, 0.29, 0.49, 0.1, 0.04, 0.17, 0.05, 0.0, 0.02, 0.03, 0.0, 0.04, 0.22, 0.04, 0.0, 0.0, 0.03, 0.03, 0.02, 0.2, 0.11, 0.03, 0.0, 0.03, 0.01, 0.0, 0.06, 0.01, 0.0, 0.02, 0.02, 0.01, 0.0, 0.04, 0.02, 0.02, 0.04, 0.22, 0.16, 0.11, 0.02, 0.14, 0.84, 0.24, 0.75, 0.74, 0.07, 0.26, 0.67, 0.06, 0.01, 0.21, 0.35, 0.0, 0.0, 0.26, 0.02, 0.0, 0.19, 0.47, 0.03, 0.09, 0.03, 0.62, 0.61, 0.37, 0.09, 0.8, 0.64, 0.2, 0.81, 0.59, 0.15, 0.09, 0.08, 0.12, 0.29, 0.09, 0.39, 0.03, 0.0, 0.02, 0.01, 0.1, 0.03, 0.04, 0.26, 0.28, 0.03, 0.02, 0.04, 0.03, 0.05, 0.0, 0.11, 0.03, 0.0, 0.0, 0.02, 0.0, 0.02, 0.09, 0.0, 0.01, 0.06, 0.15, 0.0, 0.2, 0.48, 0.45, 0.01, 0.88, 0.37, 0.06, 0.64, 0.63, 0.46, 0.04, 0.49, 0.55, 0.58, 0.36, 0.04, 0.11, 0.25, 0.01, 0.0, 0.25, 0.0, 0.0, 0.05, 0.48, 0.0, 0.28, 0.08, 0.95, 0.27, 0.09, 0.01, 0.01, 0.0, 0.05, 0.11, 0.01, 0.22, 0.25, 0.29, 0.12, 0.54, 0.53, 0.73, 0.11, 0.19, 0.32, 0.19, 0.02, 0.11, 0.0, 0.01, 0.05, 0.04, 0.08, 0.24, 0.04, 0.07, 0.01, 0.02, 0.12, 0.13, 0.12, 0.07, 0.02, 0.0, 0.0, 0.0, 0.01, 0.0, 0.01, 0.16, 0.0, 0.0, 0.4, 0.18, 0.0, 0.18, 0.71, 0.64, 0.24, 0.53, 0.93, 0.22, 0.4, 0.13, 0.65, 0.27, 0.0, 0.5, 0.47, 0.04, 0.03, 0.56, 0.34, 0.0, 0.1, 0.38, 0.01, 0.0, 0.32, 0.6, 0.52, 0.15, 0.31, 0.84, 0.46, 0.0, 0.0, 0.01, 0.17, 0.04, 0.16, 0.18, 0.0, 0.0, 0.0, 0.02, 0.0, 0.01, 0.0, 0.0, 0.03, 0.04, 0.0, 0.0, 0.1, 0.0, 0.01, 0.21, 0.22, 0.25, 0.63, 0.39, 0.2, 0.11, 0.73, 0.96, 0.63, 0.63, 0.29, 0.27, 0.5, 0.16, 0.0, 0.31, 0.37, 0.0, 0.01, 0.64, 0.04, 0.01, 0.24, 0.72, 0.31, 0.2, 0.22, 0.99, 0.48, 0.02, 0.0, 0.01, 0.0, 0.01, 0.19, 0.02, 0.17, 0.0, 0.02, 0.25, 0.54, 0.44, 0.52, 0.16, 0.27, 0.52, 0.08, 0.91, 0.78, 0.02, 0.03, 0.02, 0.07, 0.0, 0.0, 0.0, 0.0, 0.0, 0.01, 0.0, 0.0, 0.01, 0.0, 0.07, 0.0, 0.48, 0.13, 0.54, 0.36, 0.18, 0.62, 0.0, 0.0, 0.14, 0.42, 0.0, 0.0, 0.58, 0.05, 0.0, 0.1, 0.84, 0.19, 0.16, 0.44, 0.57, 0.15, 0.01, 0.08, 0.01, 0.35, 0.39, 0.2, 0.2, 0.02, 0.06, 0.0, 0.03, 0.26, 0.1, 0.08, 0.06, 0.0, 0.0, 0.04, 0.02, 0.1, 0.16, 0.02, 0.01, 0.16, 0.01, 0.0, 0.0, 0.0, 0.01, 0.04, 0.0, 0.0, 0.0, 0.09, 0.0, 0.05, 0.52, 0.33, 0.09, 0.47, 0.88, 0.35, 0.72, 0.1, 0.0, 0.23, 0.8, 0.43]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
97.994208
0.218893
940
O60260
P48556
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PSMD8
MFIKGRAPRAPPRERRRATRGGLRQVVAPPRALGSTSRPHFRRASVCRRRCRKSGGLLAASRKMAAAAVNGAAGFSSSGPAATSGAVLQAATGMYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMTDYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV
Homo sapiens
null
Tissue enhanced (skeletal)
{'Ciliated cells': '162.7', 'Basal respiratory cells': '282.0', 'Club cells': '175.2', 'Ionocytes': '172.3', 'Mucus glandular cells': '128.1', 'Serous glandular cells': '202.9', 'Gastric mucus-secreting cells': '74.3', 'Proximal enterocytes': '323.1', 'Paneth cells': '160.7', 'Distal enterocytes': '209.9', 'Intestinal goblet cells': '147.0', 'Exocrine glandular cells': '-0.733', 'Basal prostatic cells': '137.2', 'Prostatic glandular cells': '166.0', 'Breast glandular cells': '-0.322', 'Breast myoepithelial cells': '-0.508', 'Glandular and luminal cells': '140.6', 'Secretory cells': '214.7', 'Basal keratinocytes': '244.3', 'Suprabasal keratinocytes': '327.9', 'Basal squamous epithelial cells': '87.8', 'Squamous epithelial cells': '122.5', 'Alveolar cells type 1': '-0.126', 'Alveolar cells type 2': '0.252', 'Salivary duct cells': '139.0', 'Ductal cells': '0.471', 'Hepatocytes': '0.523', 'Cholangiocytes': '70.6', 'Proximal tubular cells': '0.260', 'Distal tubular cells': '288.9', 'Collecting duct cells': '81.7', 'Mesothelial cells': '-0.246', 'Sertoli cells': '-0.334', 'Granulosa cells': '127.0', 'Enteroendocrine cells': '146.4', 'Pancreatic endocrine cells': '363.4', 'Leydig cells': '-0.402', 'Excitatory neurons': '14.2', 'Inhibitory neurons': '14.8', 'Cone photoreceptor cells': '144.4', 'Rod photoreceptor cells': '83.6', 'Bipolar cells': '103.6', 'Horizontal cells': '72.4', 'Astrocytes': '7.7', 'Oligodendrocyte precursor cells': '7.5', 'Oligodendrocytes': '18.4', 'Microglial cells': '9.8', 'Muller glia cells': '181.9', 'Schwann cells': '-0.014', 'Spermatogonia': '-0.126', 'Spermatocytes': '0.137', 'Early spermatids': '0.714', 'Late spermatids': '0.625', 'Oocytes': '194.8', 'Cytotrophoblasts': '384.8', 'Syncytiotrophoblasts': '583.4', 'Extravillous trophoblasts': '349.6', 'Endothelial cells': '124.3', 'Lymphatic endothelial cells': '113.3', 'Cardiomyocytes': '0.695', 'Skeletal myocytes': '-0.400', 'Smooth muscle cells': '167.5', 'Adipocytes': '130.8', 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ductal cells': '-0.344', 'Minor salivary gland basal cells': '0.552', 'Mitotic cells (Minor salivary gland)': '0.633', 'Adipocytes (Minor salivary gland)': '0.224', 'Somatotropes': '0.354', 'Lactotropes': '0.107', 'Gonadotropes': '-0.050', 'Corticotropes': '0.088', 'Thyrotropes': '0.077', 'Undifferentiated cells (Pituitary gland)': '-0.200', 'Mitotic cells (Spleen)': '-0.058', 'Platelets': '-0.071', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.045', 'B-cells (Spleen)': '0.080', 'NK-cells (Spleen)': '-0.100', 'Amygdala excitatory': '23.1', 'Cerebellar inhibitory': '39.4', 'Cge interneuron': '33.8', 'Deep-layer corticothalamic and 6b': '23.5', 'Deep-layer intratelencephalic': '26.0', 'Deep-layer near-projecting': '29.6', 'Eccentric medium spiny neuron': '20.8', 'Hippocampal ca1-3': '21.7', 'Hippocampal ca4': '53.0', 'Hippocampal dentate gyrus': '29.2', 'Lamp5-lhx6 and chandelier': '33.2', 'Lower rhombic lip': '34.3', 'Mammillary body': '21.2', 'Medium spiny neuron': '18.7', 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'Naive B-cell': '44.4', 'Plasmacytoid DC': '205.2', 'Myeloid DC': '199.9', 'NK-cell': '99.2', 'Total PBMC': '191.9', 'Vd2 gdTCR': '178.9', 'Memory CD4 T-cell TFH': '89.8', 'Memory CD4 T-cell Th2': '86.4', 'Memory CD4 T-cell Th17': '84.6', 'Memory CD4 T-cell Th1\\/Th17': '65.8', 'Non-Vd2 gdTCR': '165.7', 'Memory CD4 T-cell Th1': '82.3', 'Terminal effector memory CD4 T-cell': '119.7', 'Central memory CD8 T-cell': '137.8', 'Effector memory CD8 T-cell': '169.8', 'Terminal effector memory CD8 T-cell': '186.5', 'Switched memory B-cell': '139.1', 'Plasmablast': '291.1', 'Non-switched memory B-cell': '117.8', 'Exhausted memory B-cell': '153.1', 'Progenitor cell': '99.7', 'Naive CD4 T-cell activated': '125.3', 'Naive CD8 T-cell activated': '128.7', 'Memory T-reg': '120.4', 'Naive T-reg': '65.4'}
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[39.1, 32.23, 32.64, 37.73, 32.69, 28.4, 28.43, 34.48, 26.97, 27.67, 34.75, 33.22, 26.69, 27.28, 22.85, 29.34, 25.06, 24.27, 26.76, 23.59, 24.0, 22.71, 31.82, 24.11, 28.91, 25.68, 28.42, 29.2, 29.92, 33.45, 30.96, 27.58, 31.63, 22.47, 30.28, 29.36, 27.9, 27.38, 33.01, 30.84, 23.91, 27.77, 24.79, 30.06, 31.52, 28.09, 26.19, 24.91, 29.53, 24.1, 20.7, 28.55, 25.57, 29.38, 22.25, 26.86, 26.41, 28.94, 24.9, 29.6, 33.73, 30.72, 32.51, 24.29, 30.55, 24.13, 25.52, 25.54, 25.25, 31.63, 19.46, 27.58, 22.4, 21.49, 20.94, 24.18, 31.06, 29.28, 31.3, 48.3, 37.88, 42.38, 52.64, 56.0, 62.79, 68.26, 68.41, 67.41, 75.29, 75.46, 72.55, 78.43, 79.36, 72.21, 71.45, 77.95, 76.07, 71.79, 74.9, 72.95, 68.7, 62.23, 67.06, 65.42, 57.05, 51.63, 57.35, 57.86, 66.99, 73.64, 73.08, 72.12, 75.7, 81.91, 79.49, 79.73, 81.45, 82.71, 80.67, 80.57, 80.77, 77.66, 72.39, 72.33, 70.27, 60.84, 56.0, 49.11, 41.35, 45.16, 46.5, 44.48, 47.63, 51.53, 53.74, 56.21, 66.12, 71.48, 73.84, 75.17, 76.29, 79.73, 80.46, 81.11, 82.78, 83.36, 84.87, 85.45, 86.27, 85.0, 86.1, 85.6, 84.42, 84.4, 83.48, 83.83, 81.49, 82.13, 78.94, 82.32, 82.93, 87.94, 85.87, 87.98, 87.64, 88.87, 87.42, 86.18, 86.32, 84.61, 82.81, 80.66, 75.12, 69.48, 69.59, 65.05, 64.8, 57.26, 57.93, 51.82, 49.76, 54.38, 56.32, 60.02, 60.33, 65.79, 71.78, 78.63, 79.77, 83.24, 85.05, 84.46, 87.29, 86.81, 87.59, 88.38, 86.88, 87.11, 88.91, 88.22, 83.99, 87.58, 86.4, 87.46, 87.57, 90.36, 89.81, 90.58, 90.4, 89.63, 85.66, 85.18, 87.13, 83.92, 79.0, 74.06, 69.17, 67.55, 68.62, 67.91, 65.6, 68.9, 73.82, 79.08, 79.53, 82.29, 84.23, 84.4, 86.48, 87.58, 87.32, 87.64, 87.63, 90.13, 88.23, 86.41, 86.97, 86.46, 84.69, 83.54, 83.01, 83.67, 83.32, 82.98, 78.86, 79.48, 77.76, 70.83, 70.24, 70.26, 66.86, 65.94, 66.75, 71.65, 72.81, 76.36, 81.57, 81.31, 82.83, 83.16, 84.0, 86.94, 85.74, 83.6, 85.44, 86.64, 85.71, 85.24, 85.38, 85.91, 84.72, 82.81, 84.36, 85.29, 83.08, 79.95, 83.49, 81.77, 78.66, 76.02, 76.06, 79.96, 78.59, 73.98, 79.13, 81.21, 75.83, 78.95, 79.83, 78.88, 72.47, 68.93, 66.27, 66.3, 70.81, 69.04, 73.71, 73.56, 68.56, 73.18, 77.72, 70.37, 72.94, 74.24, 76.68, 67.95, 66.87, 73.31, 67.82, 64.59, 66.73, 59.9, 59.41, 65.66, 65.0, 62.8, 57.24, 60.37, 54.5, 50.99, 47.85, 46.23, 39.83, 40.05, 49.8, 46.91, 50.94, 57.3, 64.17, 71.37, 81.11, 84.42, 88.25, 90.89, 90.78, 92.15, 94.33, 93.37, 94.52, 93.38, 93.79, 91.81, 92.49, 91.21, 90.53, 89.25, 85.9, 83.87, 76.7, 62.83]
[0.99, 0.96, 0.98, 0.96, 0.98, 1.0, 0.95, 1.0, 0.97, 1.0, 1.0, 0.98, 0.94, 0.88, 0.93, 0.91, 0.98, 0.99, 0.95, 1.0, 0.97, 1.0, 0.98, 0.96, 0.96, 0.91, 0.98, 0.97, 0.96, 0.98, 0.95, 0.95, 0.95, 0.91, 0.97, 0.99, 0.97, 0.99, 0.93, 0.96, 0.89, 0.94, 0.94, 0.86, 0.92, 0.85, 0.82, 0.92, 0.92, 0.99, 0.99, 0.98, 1.0, 0.96, 0.99, 1.0, 0.95, 0.97, 0.9, 0.96, 0.88, 0.99, 0.91, 0.95, 0.95, 0.91, 0.96, 0.96, 0.97, 0.93, 0.87, 0.91, 0.99, 0.81, 0.94, 0.73, 0.81, 0.82, 0.61, 0.69, 0.69, 0.75, 0.6, 0.31, 0.33, 0.55, 0.25, 0.16, 0.72, 0.41, 0.0, 0.41, 0.36, 0.1, 0.16, 0.7, 0.53, 0.01, 0.48, 0.52, 0.3, 0.21, 0.74, 0.6, 0.93, 0.74, 0.21, 0.33, 0.44, 0.65, 0.55, 0.02, 0.31, 0.66, 0.2, 0.02, 0.38, 0.45, 0.0, 0.29, 0.61, 0.12, 0.14, 0.55, 0.72, 0.13, 0.47, 0.6, 0.75, 0.72, 0.78, 0.64, 0.82, 0.61, 0.92, 0.28, 0.44, 0.59, 0.7, 0.14, 0.09, 0.32, 0.09, 0.08, 0.11, 0.22, 0.03, 0.08, 0.04, 0.12, 0.0, 0.0, 0.28, 0.09, 0.01, 0.12, 0.53, 0.47, 0.6, 0.26, 0.35, 0.67, 0.12, 0.02, 0.55, 0.57, 0.03, 0.04, 0.49, 0.32, 0.0, 0.23, 0.51, 0.18, 0.16, 0.35, 0.76, 0.26, 0.56, 1.0, 0.56, 0.17, 0.69, 0.59, 0.11, 0.73, 0.52, 0.16, 0.13, 0.25, 0.04, 0.16, 0.0, 0.02, 0.06, 0.0, 0.02, 0.04, 0.06, 0.11, 0.11, 0.4, 0.68, 0.3, 0.36, 0.7, 0.42, 0.02, 0.47, 0.53, 0.13, 0.18, 0.82, 0.54, 0.16, 0.38, 0.6, 0.8, 0.23, 0.23, 0.84, 0.77, 0.18, 0.69, 0.25, 0.01, 0.6, 0.2, 0.02, 0.29, 0.27, 0.04, 0.16, 0.55, 0.25, 0.3, 0.7, 0.49, 0.38, 0.23, 0.24, 0.56, 0.4, 0.05, 0.27, 0.74, 0.18, 0.4, 0.76, 0.73, 0.28, 0.5, 0.28, 0.84, 0.38, 0.07, 0.38, 0.27, 0.03, 0.06, 0.39, 0.34, 0.03, 0.05, 0.47, 0.36, 0.06, 0.28, 0.5, 0.59, 0.05, 0.07, 0.18, 0.52, 0.04, 0.31, 0.72, 0.81, 0.53, 0.75, 0.7, 0.04, 0.38, 0.25, 0.53, 0.42, 0.0, 0.2, 0.67, 0.27, 0.07, 0.33, 0.12, 0.9, 0.42, 0.51, 0.73, 0.53, 0.01, 0.39, 0.5, 0.31, 0.04, 0.76, 0.76, 0.45, 0.65, 0.12, 0.55, 0.62, 0.35, 0.98, 0.75, 0.54, 0.46, 0.03, 0.24, 0.15, 0.73, 0.94, 0.92, 0.7, 0.9, 0.79, 0.75, 0.84, 0.69, 0.8, 0.66, 0.72, 0.43, 0.6, 0.68, 0.56, 0.44, 0.42, 0.63, 0.52, 0.66, 0.64, 0.58, 0.63, 0.42, 0.74, 0.54, 0.5, 0.72, 0.8, 0.79, 0.81]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
64.464286
0.5254
2,173
O60260
P49327
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
FASN
MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGPEVQQVPAGERPLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG
Homo sapiens
Cytoplasm, Melanosome
Tissue enhanced (adipose tissue, breast)
{'Ciliated cells': '28.0', 'Basal respiratory cells': '32.1', 'Club cells': '50.8', 'Ionocytes': '41.2', 'Mucus glandular cells': '14.2', 'Serous glandular cells': '26.8', 'Gastric mucus-secreting cells': '32.4', 'Proximal enterocytes': '6.1', 'Paneth cells': '9.2', 'Distal enterocytes': '32.4', 'Intestinal goblet cells': '17.1', 'Exocrine glandular cells': '-0.566', 'Basal prostatic cells': '38.8', 'Prostatic glandular cells': '52.7', 'Breast glandular cells': '-0.135', 'Breast myoepithelial cells': '-0.446', 'Glandular and luminal cells': '14.2', 'Secretory cells': '9.1', 'Basal keratinocytes': '36.1', 'Suprabasal keratinocytes': '74.8', 'Basal squamous epithelial cells': '14.4', 'Squamous epithelial cells': '36.1', 'Alveolar cells type 1': '-0.056', 'Alveolar cells type 2': '0.788', 'Salivary duct cells': '10.6', 'Ductal cells': '0.532', 'Hepatocytes': '0.508', 'Cholangiocytes': '21.0', 'Proximal tubular cells': '0.178', 'Distal tubular cells': '6.1', 'Collecting duct cells': '11.7', 'Mesothelial cells': '-0.246', 'Sertoli cells': '0.425', 'Granulosa cells': '9.1', 'Enteroendocrine cells': '23.1', 'Pancreatic endocrine cells': '18.7', 'Leydig cells': '0.498', 'Excitatory neurons': '11.5', 'Inhibitory neurons': '12.0', 'Cone photoreceptor cells': '6.8', 'Rod photoreceptor cells': '8.7', 'Bipolar cells': '33.9', 'Horizontal cells': '79.9', 'Astrocytes': '26.9', 'Oligodendrocyte precursor cells': '10.8', 'Oligodendrocytes': '16.4', 'Microglial cells': '4.5', 'Muller glia cells': '11.5', 'Schwann cells': '-0.094', 'Spermatogonia': '0.478', 'Spermatocytes': '0.202', 'Early spermatids': '-0.419', 'Late spermatids': '-0.490', 'Oocytes': '2.2', 'Cytotrophoblasts': '33.7', 'Syncytiotrophoblasts': '27.6', 'Extravillous trophoblasts': '78.9', 'Endothelial cells': '17.4', 'Lymphatic endothelial cells': '12.9', 'Cardiomyocytes': '0.397', 'Skeletal myocytes': '-0.159', 'Smooth muscle cells': '14.8', 'Adipocytes': '8.5', 'Melanocytes': '-0.101', 'Fibroblasts': '19.0', 'Peritubular cells': '0.355', 'Endometrial stromal cells': '18.7', 'Ovarian stromal cells': '4.5', 'Undifferentiated cells': '26.1', 'T-cells': '12.4', 'B-cells': '5.9', 'Plasma cells': '15.4', 'Nk-cells': '9.3', 'Granulocytes': '10.3', 'Monocytes': '5.0', 'Macrophages': '8.8', 'Hofbauer cells': '9.2', 'Kupffer cells': '42.3', 'Dendritic cells': '11.5', 'Langerhans cells': '-0.045', 'Erythroid cells': '0.077', 'Adipocytes (Subcutaneous)': '0.727', 'Adipocytes (Visceral)': '0.774', 'Breast glandular cells (progenitors)': '-0.200', 'Adipocytes (Breast)': '0.608', 'Colon enterocytes': '0.091', 'Colon enteroendocrine cells': '0.065', 'Enteric glia cells': '-0.407', 'Mitotic cells (Colon)': '0.098', 'Mitotic cells (Heart)': '0.447', 'Podocytes': '-0.236', 'Ascending Loop of Henle cells': '0.360', 'Intercalated cells': '-0.260', 'Cholangiocyte': '-0.102', 'NK-cells (Liver)': '0.099', 'Respiratory ciliated cells': '-0.151', 'Mitotic cells (Lung)': '0.197', 'NK-cells (Lung)': '-0.512', 'B-cells (Lung)': '-0.334', 'Alpha cells': '0.282', 'Beta cells': '0.256', 'Prostate glandular cells': '0.736', 'Prostate basal glandular cells': '0.310', 'Urothelial cells': '-0.016', 'Keratinocyte (other)': '-0.323', 'Keratinocyte (granular)': '0.111', 'Hair cortex cells': '0.112', 'Inner root sheath cells': '0.101', 'Outer root sheath cells': '0.136', 'Sebaceous gland cells': '0.778', 'Eccrine sweat gland cells': '0.081', 'Adipocytes (Skin)': '0.304', 'Mitotic cells (Skin)': '0.000', 'Parietal cells': '0.333', 'Chief cells': '0.443', 'Gastric mucous cells': '0.395', 'Gastric enteroendocrine cells': '0.344', 'Mitotic cells (Stomach)': '0.278', 'Parafollicular cells': '-0.040', 'Thyroid glandular cells': '0.567', 'Mitotic cells (Thyroid)': '-0.102', 'Adrenal cortex cells': '0.502', 'Adrenal medulla cells': '0.046', 'Mitotic cells (Adrenal gland)': '0.226', 'Minor salivary glandular cells': '0.023', 'Minor salivary gland ductal cells': '-0.108', 'Minor salivary gland basal cells': '0.248', 'Mitotic cells (Minor salivary gland)': '0.198', 'Adipocytes (Minor salivary gland)': '0.213', 'Somatotropes': '0.007', 'Lactotropes': '-0.007', 'Gonadotropes': '-0.197', 'Corticotropes': '0.728', 'Thyrotropes': '0.170', 'Undifferentiated cells (Pituitary gland)': '-0.238', 'Mitotic cells (Spleen)': '0.141', 'Platelets': '-0.085', 'Erythrocytes': '-0.059', 'Hematopoietic stem cells': '-0.195', 'B-cells (Spleen)': '0.351', 'NK-cells (Spleen)': '0.062', 'Amygdala excitatory': '19.4', 'Cerebellar inhibitory': '93.4', 'Cge interneuron': '27.0', 'Deep-layer corticothalamic and 6b': '17.8', 'Deep-layer intratelencephalic': '23.4', 'Deep-layer near-projecting': '25.9', 'Eccentric medium spiny neuron': '18.5', 'Hippocampal ca1-3': '17.3', 'Hippocampal ca4': '21.2', 'Hippocampal dentate gyrus': '14.2', 'Lamp5-lhx6 and chandelier': '23.5', 'Lower rhombic lip': '32.4', 'Mammillary body': '10.0', 'Medium spiny neuron': '16.0', 'Mge interneuron': '18.7', 'Midbrain-derived inhibitory': '52.4', 'Miscellaneous': '22.0', 'Splatter': '23.3', 'Thalamic excitatory': '29.0', 'Upper rhombic lip': '25.9', 'Upper-layer intratelencephalic': '17.0', 'Astrocyte': '36.2', 'Bergmann glia': '17.8', 'Central nervous system macrophage': '6.9', 'Choroid plexus epithelial cell': '12.1', 'Committed oligodendrocyte precursor': '34.7', 'Ependymal cell': '18.8', 'Oligodendrocyte': '32.1', 'Oligodendrocyte precursor cell': '21.7', 'Endothelial cell': '5.5', 'Pericyte': '9.9', 'Vascular associated smooth muscle cell': '15.4', 'Fibroblast': '15.2', 'Leukocyte': '10.9', 'Basophil': '0.1', 'Eosinophil': '0.0', 'Neutrophil': '0.2', 'Classical monocyte': '5.3', 'Non-classical monocyte': '4.1', 'Intermediate monocyte': '3.5', 'T-reg': '6.3', 'GdT-cell': '0.1', 'MAIT T-cell': '3.7', 'Memory CD4 T-cell': '0.2', 'Naive CD4 T-cell': '11.3', 'Memory CD8 T-cell': '0.2', 'Naive CD8 T-cell': '19.7', 'Memory B-cell': '0.0', 'Naive B-cell': '3.7', 'Plasmacytoid DC': '3.9', 'Myeloid DC': '3.5', 'NK-cell': '13.6', 'Total PBMC': '2.2', 'Vd2 gdTCR': '4.5', 'Memory CD4 T-cell Th1\\/Th17': '14.9', 'Memory CD4 T-cell Th17': '27.5', 'Memory CD4 T-cell Th2': '35.8', 'Non-Vd2 gdTCR': '11.0', 'Memory CD4 T-cell Th1': '36.0', 'Memory CD4 T-cell TFH': '69.9', 'Terminal effector memory CD4 T-cell': '4.6', 'Central memory CD8 T-cell': '4.1', 'Effector memory CD8 T-cell': '3.4', 'Terminal effector memory CD8 T-cell': '3.3', 'Non-switched memory B-cell': '2.5', 'Plasmablast': '5.0', 'Switched memory B-cell': '1.5', 'Exhausted memory B-cell': '1.8', 'Progenitor cell': '5.7', 'Memory T-reg': '36.3', 'Naive CD4 T-cell activated': '77.4', 'Naive CD8 T-cell activated': '86.4', 'Naive T-reg': '20.6'}
1XKT, 2CG5, 2JFD, 2JFK, 2PX6, 3HHD, 3TJM, 4PIV, 4W82, 4W9N, 4Z49, 5C37, 6NNA, 7MHD, 7MHE, 8EYI, 8EYK, 8G7X, 8GKC
{'Adipose Tissue': 643.0579235880399, 'Adrenal Gland': 50.82914728682171, 'Bladder': 61.9547619047619, 'Blood': 20.211749407965552, 'Blood Vessel': 63.16825617977528, 'Brain': 60.582436790310375, 'Breast': 523.2381481481482, 'Cervix Uteri': 49.59578947368421, 'Colon': 38.83715532734275, 'Esophagus': 66.04310865051903, 'Fallopian Tube': 39.621111111111105, 'Heart': 15.84287781649245, 'Kidney': 16.600123595505618, 'Liver': 146.771296460177, 'Lung': 128.46955017301036, 'Muscle': 27.402997509339976, 'Nerve': 110.618901453958, 'Ovary': 39.32761111111111, 'Pancreas': 15.425536585365856, 'Pituitary': 158.83374558303885, 'Prostate': 157.39608163265308, 'Salivary Gland': 65.55281481481482, 'Skin': 131.1030458817026, 'Small Intestine': 54.713422459893046, 'Spleen': 18.278008298755186, 'Stomach': 92.0099860724234, 'Testis': 33.143326869806096, 'Thyroid': 53.63954058192956, 'Uterus': 40.136267605633805, 'Vagina': 69.89929487179488}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
85.71039
0.277025
56
O60260
P49792
16332688, BioGrid E3Net
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
RANBP2
MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDPKAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYANLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKMGQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLTRYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIHRKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIGRSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVNGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGPVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDDYFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLPTQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDGYSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKSVFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGSDRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAVRIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNPSNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQNTKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCAACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANATRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLKCVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFKFGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGTGFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFSSQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRVKLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTERVWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSESVKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELQKVQEAQKSQTEEITSTTDSVYTGGTEVMVPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFSNIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCRRITITECGQI
Homo sapiens
Nucleus, Nucleus membrane, Nucleus, nuclear pore complex, Nucleus envelope
Low tissue specificity
{'Ciliated cells': '61.0', 'Basal respiratory cells': '40.0', 'Club cells': '48.3', 'Ionocytes': '42.3', 'Mucus glandular cells': '107.6', 'Serous glandular cells': '64.1', 'Gastric mucus-secreting cells': '62.5', 'Proximal enterocytes': '23.6', 'Paneth cells': '34.0', 'Distal enterocytes': '22.3', 'Intestinal goblet cells': '50.6', 'Exocrine glandular cells': '-0.617', 'Basal prostatic cells': '91.4', 'Prostatic glandular cells': '130.3', 'Breast glandular cells': '0.489', 'Breast myoepithelial cells': '0.508', 'Glandular and luminal cells': '130.5', 'Secretory cells': '49.9', 'Basal keratinocytes': '59.5', 'Suprabasal keratinocytes': '61.0', 'Basal squamous epithelial cells': '55.0', 'Squamous epithelial cells': '51.4', 'Alveolar cells type 1': '0.272', 'Alveolar cells type 2': '-0.201', 'Salivary duct cells': '65.7', 'Ductal cells': '0.630', 'Hepatocytes': '0.401', 'Cholangiocytes': '40.1', 'Proximal tubular cells': '0.138', 'Distal tubular cells': '0.0', 'Collecting duct cells': '48.6', 'Mesothelial cells': '0.111', 'Sertoli cells': '0.092', 'Granulosa cells': '38.6', 'Enteroendocrine cells': '60.6', 'Pancreatic endocrine cells': '27.2', 'Leydig cells': '0.072', 'Excitatory neurons': '121.3', 'Inhibitory neurons': '88.3', 'Cone photoreceptor cells': '62.9', 'Rod photoreceptor cells': '36.6', 'Bipolar cells': '44.7', 'Horizontal cells': '30.2', 'Astrocytes': '46.1', 'Oligodendrocyte precursor cells': '41.5', 'Oligodendrocytes': '74.4', 'Microglial cells': '52.8', 'Muller glia cells': '20.0', 'Schwann cells': '0.148', 'Spermatogonia': '0.480', 'Spermatocytes': '0.644', 'Early spermatids': '0.077', 'Late spermatids': '-0.123', 'Oocytes': '19.9', 'Cytotrophoblasts': '28.3', 'Syncytiotrophoblasts': '44.4', 'Extravillous trophoblasts': '16.0', 'Endothelial cells': '56.5', 'Lymphatic endothelial cells': '55.1', 'Cardiomyocytes': '0.635', 'Skeletal myocytes': '-0.194', 'Smooth muscle cells': '55.8', 'Adipocytes': '50.7', 'Melanocytes': '0.089', 'Fibroblasts': '47.1', 'Peritubular cells': '0.077', 'Endometrial stromal cells': '59.9', 'Ovarian stromal cells': '32.7', 'Undifferentiated cells': '31.6', 'T-cells': '110.4', 'B-cells': '80.9', 'Plasma cells': '96.1', 'Nk-cells': '88.2', 'Granulocytes': '164.7', 'Monocytes': '113.2', 'Macrophages': '133.4', 'Hofbauer cells': '55.4', 'Kupffer cells': '36.2', 'Dendritic cells': '310.2', 'Langerhans cells': '0.083', 'Erythroid cells': '-0.077', 'Adipocytes (Subcutaneous)': '-0.034', 'Adipocytes (Visceral)': '-0.111', 'Breast glandular cells (progenitors)': '0.344', 'Adipocytes (Breast)': '-0.437', 'Colon enterocytes': '-0.137', 'Colon enteroendocrine cells': '0.224', 'Enteric glia cells': '-0.135', 'Mitotic cells (Colon)': '-0.073', 'Mitotic cells (Heart)': '0.479', 'Podocytes': '-0.098', 'Ascending Loop of Henle cells': '0.464', 'Intercalated cells': '-0.020', 'Cholangiocyte': '0.374', 'NK-cells (Liver)': '-0.359', 'Respiratory ciliated cells': '0.039', 'Mitotic cells (Lung)': '-0.232', 'NK-cells (Lung)': '0.315', 'B-cells (Lung)': '0.119', 'Alpha cells': '0.373', 'Beta cells': '0.265', 'Prostate glandular cells': '0.248', 'Prostate basal glandular cells': '0.184', 'Urothelial cells': '0.008', 'Keratinocyte (other)': '0.198', 'Keratinocyte (granular)': '0.052', 'Hair cortex cells': '-0.076', 'Inner root sheath cells': '0.010', 'Outer root sheath cells': '0.012', 'Sebaceous gland cells': '-0.040', 'Eccrine sweat gland cells': '0.033', 'Adipocytes (Skin)': '-0.095', 'Mitotic cells (Skin)': '0.144', 'Parietal cells': '-0.487', 'Chief cells': '-0.285', 'Gastric mucous cells': '-0.342', 'Gastric enteroendocrine cells': '-0.265', 'Mitotic cells (Stomach)': '-0.009', 'Parafollicular cells': '0.093', 'Thyroid glandular cells': '0.434', 'Mitotic cells (Thyroid)': '-0.027', 'Adrenal cortex cells': '0.270', 'Adrenal medulla cells': '0.083', 'Mitotic cells (Adrenal gland)': '-0.062', 'Minor salivary glandular cells': '0.494', 'Minor salivary gland ductal cells': '0.287', 'Minor salivary gland basal cells': '0.038', 'Mitotic cells (Minor salivary gland)': '0.006', 'Adipocytes (Minor salivary gland)': '-0.060', 'Somatotropes': '0.043', 'Lactotropes': '0.063', 'Gonadotropes': '0.106', 'Corticotropes': '0.142', 'Thyrotropes': '0.082', 'Undifferentiated cells (Pituitary gland)': '-0.006', 'Mitotic cells (Spleen)': '-0.097', 'Platelets': '-0.198', 'Erythrocytes': '-0.080', 'Hematopoietic stem cells': '-0.304', 'B-cells (Spleen)': '0.350', 'NK-cells (Spleen)': '0.278', 'Amygdala excitatory': '105.5', 'Cerebellar inhibitory': '110.1', 'Cge interneuron': '96.7', 'Deep-layer corticothalamic and 6b': '109.9', 'Deep-layer intratelencephalic': '113.7', 'Deep-layer near-projecting': '91.7', 'Eccentric medium spiny neuron': '104.7', 'Hippocampal ca1-3': '125.0', 'Hippocampal ca4': '94.0', 'Hippocampal dentate gyrus': '98.9', 'Lamp5-lhx6 and chandelier': '103.6', 'Lower rhombic lip': '107.4', 'Mammillary body': '113.3', 'Medium spiny neuron': '107.2', 'Mge interneuron': '117.3', 'Midbrain-derived inhibitory': '112.2', 'Miscellaneous': '98.5', 'Splatter': '99.3', 'Thalamic excitatory': '128.0', 'Upper rhombic lip': '115.6', 'Upper-layer intratelencephalic': '120.9', 'Astrocyte': '75.9', 'Bergmann glia': '50.1', 'Central nervous system macrophage': '209.5', 'Choroid plexus epithelial cell': '89.4', 'Committed oligodendrocyte precursor': '75.9', 'Ependymal cell': '81.2', 'Oligodendrocyte': '95.4', 'Oligodendrocyte precursor cell': '68.3', 'Endothelial cell': '135.7', 'Pericyte': '105.1', 'Vascular associated smooth muscle cell': '317.4', 'Fibroblast': '124.7', 'Leukocyte': '163.9', 'Basophil': '14.4', 'Eosinophil': '0.9', 'Neutrophil': '9.1', 'Classical monocyte': '46.8', 'Non-classical monocyte': '24.7', 'Intermediate monocyte': '10.7', 'T-reg': '15.4', 'GdT-cell': '2.1', 'MAIT T-cell': '18.6', 'Memory CD4 T-cell': '1.7', 'Naive CD4 T-cell': '63.3', 'Memory CD8 T-cell': '2.3', 'Naive CD8 T-cell': '55.6', 'Memory B-cell': '1.8', 'Naive B-cell': '44.7', 'Plasmacytoid DC': '15.4', 'Myeloid DC': '14.7', 'NK-cell': '34.1', 'Total PBMC': '12.8', 'Vd2 gdTCR': '15.3', 'Memory CD4 T-cell Th1\\/Th17': '65.4', 'Memory CD4 T-cell Th17': '51.6', 'Memory CD4 T-cell Th2': '56.9', 'Non-Vd2 gdTCR': '17.5', 'Memory CD4 T-cell Th1': '54.3', 'Memory CD4 T-cell TFH': '42.8', 'Terminal effector memory CD4 T-cell': '19.0', 'Central memory CD8 T-cell': '16.6', 'Effector memory CD8 T-cell': '16.3', 'Terminal effector memory CD8 T-cell': '13.7', 'Non-switched memory B-cell': '11.9', 'Plasmablast': '19.0', 'Switched memory B-cell': '13.5', 'Exhausted memory B-cell': '14.2', 'Progenitor cell': '14.6', 'Memory T-reg': '41.1', 'Naive CD4 T-cell activated': '148.5', 'Naive CD8 T-cell activated': '165.9', 'Naive T-reg': '62.7'}
1RRP, 1XKE, 1Z5S, 2LAS, 3UIN, 3UIO, 3UIP, 4GA0, 4I9Y, 4L6E, 4LQW, 5CLL, 5CLQ, 7MNJ, 7MNK, 7MNL, 7MNM, 7MNN, 7MNO, 7MNP, 7MNQ, 7MNR, 7MNS, 7MNT, 7MNU, 7MNV, 7MNW, 7MNX, 7MNY, 7MNZ, 7R5J, 7R5K
{'Adipose Tissue': 24.739202657807308, 'Adrenal Gland': 30.81093410852713, 'Bladder': 26.040000000000003, 'Blood': 12.393133153928956, 'Blood Vessel': 34.570389513108616, 'Brain': 14.24924753974262, 'Breast': 24.58944008714597, 'Cervix Uteri': 30.84263157894737, 'Colon': 23.63215019255456, 'Esophagus': 24.572831833910033, 'Fallopian Tube': 34.68222222222222, 'Heart': 11.87585737514518, 'Kidney': 12.025662921348314, 'Liver': 9.990641592920356, 'Lung': 30.473131487889276, 'Muscle': 24.74682689912827, 'Nerve': 28.60599353796446, 'Ovary': 53.131055555555555, 'Pancreas': 13.00122256097561, 'Pituitary': 43.481307420494694, 'Prostate': 31.88008163265306, 'Salivary Gland': 24.11623456790123, 'Skin': 28.130817025981205, 'Small Intestine': 23.6158128342246, 'Spleen': 21.623091286307055, 'Stomach': 23.202038997214483, 'Testis': 40.93897506925207, 'Thyroid': 34.26866768759571, 'Uterus': 35.537887323943664, 'Vagina': 25.881282051282053}
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null
null
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
null
null
26
O60260
P50416
33082525, 23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
CPT1A
MAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKINRTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYILPTHIQAARAGNAIHAILLYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSRIPGEETDTIQHMRDSKHIVVYHRGRYFKVWLYHDGRLLKPREMEQQMQRILDNTSEPQPGEARLAALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTLDETEEGYRSEDPDTSMDSYAKSLLHGRCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQEVIETSLNTANLLANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMVDPAQTVEQRLKLFKLASEKHQHMYRLAMTGSGIDRHLFCLYVVSKYLAVESPFLKEVLSEPWRLSTSQTPQQQVELFDLENNPEYVSSGGGFGPVADDGYGVSYILVGENLINFHISSKFSCPETDSHRFGRHLKEAMTDIITLFGLSSNSKK
Homo sapiens
Mitochondrion outer membrane
Low tissue specificity
{'Ciliated cells': '19.4', 'Basal respiratory cells': '8.3', 'Club cells': '11.4', 'Ionocytes': '9.9', 'Mucus glandular cells': '11.2', 'Serous glandular cells': '38.2', 'Gastric mucus-secreting cells': '27.7', 'Proximal enterocytes': '79.1', 'Paneth cells': '36.3', 'Distal enterocytes': '119.3', 'Intestinal goblet cells': '40.4', 'Exocrine glandular cells': '-0.395', 'Basal prostatic cells': '25.5', 'Prostatic glandular cells': '13.7', 'Breast glandular cells': '0.186', 'Breast myoepithelial cells': '0.083', 'Glandular and luminal cells': '51.3', 'Secretory cells': '14.7', 'Basal keratinocytes': '13.3', 'Suprabasal keratinocytes': '8.1', 'Basal squamous epithelial cells': '21.1', 'Squamous epithelial cells': '13.2', 'Alveolar cells type 1': '0.109', 'Alveolar cells type 2': '-0.062', 'Salivary duct cells': '25.0', 'Ductal cells': '0.370', 'Hepatocytes': '0.411', 'Cholangiocytes': '28.6', 'Proximal tubular cells': '0.198', 'Distal tubular cells': '12.3', 'Collecting duct cells': '25.3', 'Mesothelial cells': '0.356', 'Sertoli cells': '0.647', 'Granulosa cells': '23.5', 'Enteroendocrine cells': '42.1', 'Pancreatic endocrine cells': '8.5', 'Leydig cells': '0.511', 'Excitatory neurons': '5.4', 'Inhibitory neurons': '5.5', 'Cone photoreceptor cells': '47.6', 'Rod photoreceptor cells': '42.5', 'Bipolar cells': '5.5', 'Horizontal cells': '0.6', 'Astrocytes': '33.8', 'Oligodendrocyte precursor cells': '6.6', 'Oligodendrocytes': '1.6', 'Microglial cells': '26.8', 'Muller glia cells': '13.2', 'Schwann cells': '0.068', 'Spermatogonia': '0.486', 'Spermatocytes': '0.209', 'Early spermatids': '-0.272', 'Late spermatids': '-0.522', 'Oocytes': '4.4', 'Cytotrophoblasts': '15.8', 'Syncytiotrophoblasts': '6.9', 'Extravillous trophoblasts': '3.7', 'Endothelial cells': '37.4', 'Lymphatic endothelial cells': '31.1', 'Cardiomyocytes': '0.588', 'Skeletal myocytes': '-0.258', 'Smooth muscle cells': '28.6', 'Adipocytes': '40.3', 'Melanocytes': '-0.182', 'Fibroblasts': '18.1', 'Peritubular cells': '0.504', 'Endometrial stromal cells': '21.7', 'Ovarian stromal cells': '12.4', 'Undifferentiated cells': '56.8', 'T-cells': '21.1', 'B-cells': '13.0', 'Plasma cells': '24.0', 'Nk-cells': '42.0', 'Granulocytes': '27.8', 'Monocytes': '63.3', 'Macrophages': '26.3', 'Hofbauer cells': '19.4', 'Kupffer cells': '46.7', 'Dendritic cells': '39.4', 'Langerhans cells': '-0.143', 'Erythroid cells': '-0.038', 'Adipocytes (Subcutaneous)': '-0.366', 'Adipocytes (Visceral)': '-0.286', 'Breast glandular cells (progenitors)': '0.191', 'Adipocytes (Breast)': '-0.075', 'Colon enterocytes': '0.043', 'Colon enteroendocrine cells': '0.049', 'Enteric glia cells': '-0.205', 'Mitotic cells (Colon)': '0.044', 'Mitotic cells (Heart)': '0.450', 'Podocytes': '-0.121', 'Ascending Loop of Henle cells': '0.456', 'Intercalated cells': '0.103', 'Cholangiocyte': '0.183', 'NK-cells (Liver)': '-0.128', 'Respiratory ciliated cells': '-0.023', 'Mitotic cells (Lung)': '0.122', 'NK-cells (Lung)': '-0.012', 'B-cells (Lung)': '-0.197', 'Alpha cells': '0.345', 'Beta cells': '0.192', 'Prostate glandular cells': '0.070', 'Prostate basal glandular cells': '0.207', 'Urothelial cells': '0.030', 'Keratinocyte (other)': '-0.339', 'Keratinocyte (granular)': '-0.187', 'Hair cortex cells': '0.207', 'Inner root sheath cells': '0.280', 'Outer root sheath cells': '0.155', 'Sebaceous gland cells': '-0.088', 'Eccrine sweat gland cells': '0.329', 'Adipocytes (Skin)': '0.344', 'Mitotic cells (Skin)': '0.026', 'Parietal cells': '-0.315', 'Chief cells': '-0.388', 'Gastric mucous cells': '-0.132', 'Gastric enteroendocrine cells': '-0.284', 'Mitotic cells (Stomach)': '0.149', 'Parafollicular cells': '-0.062', 'Thyroid glandular cells': '0.075', 'Mitotic cells (Thyroid)': '0.042', 'Adrenal cortex cells': '0.612', 'Adrenal medulla cells': '0.000', 'Mitotic cells (Adrenal gland)': '0.309', 'Minor salivary glandular cells': '0.404', 'Minor salivary gland ductal cells': '0.332', 'Minor salivary gland basal cells': '0.204', 'Mitotic cells (Minor salivary gland)': '0.078', 'Adipocytes (Minor salivary gland)': '0.285', 'Somatotropes': '-0.185', 'Lactotropes': '-0.240', 'Gonadotropes': '0.016', 'Corticotropes': '-0.064', 'Thyrotropes': '0.026', 'Undifferentiated cells (Pituitary gland)': '0.372', 'Mitotic cells (Spleen)': '-0.164', 'Platelets': '-0.155', 'Erythrocytes': '-0.072', 'Hematopoietic stem cells': '-0.122', 'B-cells (Spleen)': '0.045', 'NK-cells (Spleen)': '0.129', 'Amygdala excitatory': '2.6', 'Cerebellar inhibitory': '4.4', 'Cge interneuron': '4.3', 'Deep-layer corticothalamic and 6b': '2.7', 'Deep-layer intratelencephalic': '6.9', 'Deep-layer near-projecting': '1.2', 'Eccentric medium spiny neuron': '2.7', 'Hippocampal ca1-3': '10.2', 'Hippocampal ca4': '9.0', 'Hippocampal dentate gyrus': '0.4', 'Lamp5-lhx6 and chandelier': '12.5', 'Lower rhombic lip': '21.0', 'Mammillary body': '19.4', 'Medium spiny neuron': '1.4', 'Mge interneuron': '12.7', 'Midbrain-derived inhibitory': '3.4', 'Miscellaneous': '3.8', 'Splatter': '13.4', 'Thalamic excitatory': '27.5', 'Upper rhombic lip': '3.5', 'Upper-layer intratelencephalic': '3.1', 'Astrocyte': '64.4', 'Bergmann glia': '51.2', 'Central nervous system macrophage': '6.4', 'Choroid plexus epithelial cell': '29.8', 'Committed oligodendrocyte precursor': '7.6', 'Ependymal cell': '27.0', 'Oligodendrocyte': '1.4', 'Oligodendrocyte precursor cell': '19.1', 'Endothelial cell': '107.2', 'Pericyte': '122.6', 'Vascular associated smooth muscle cell': '93.2', 'Fibroblast': '115.9', 'Leukocyte': '52.0', 'Basophil': '22.8', 'Eosinophil': '9.5', 'Neutrophil': '11.1', 'Classical monocyte': '52.3', 'Non-classical monocyte': '57.2', 'Intermediate monocyte': '22.9', 'T-reg': '6.3', 'GdT-cell': '7.3', 'MAIT T-cell': '10.2', 'Memory CD4 T-cell': '4.4', 'Naive CD4 T-cell': '25.7', 'Memory CD8 T-cell': '4.4', 'Naive CD8 T-cell': '25.9', 'Memory B-cell': '1.9', 'Naive B-cell': '11.5', 'Plasmacytoid DC': '18.6', 'Myeloid DC': '15.5', 'NK-cell': '80.2', 'Total PBMC': '12.0', 'Vd2 gdTCR': '15.9', 'Memory CD4 T-cell Th1\\/Th17': '37.5', 'Memory CD4 T-cell Th17': '36.8', 'Memory CD4 T-cell Th2': '40.9', 'Non-Vd2 gdTCR': '20.8', 'Memory CD4 T-cell Th1': '41.5', 'Memory CD4 T-cell TFH': '41.0', 'Terminal effector memory CD4 T-cell': '17.7', 'Central memory CD8 T-cell': '7.9', 'Effector memory CD8 T-cell': '16.6', 'Terminal effector memory CD8 T-cell': '22.8', 'Non-switched memory B-cell': '5.4', 'Plasmablast': '13.8', 'Switched memory B-cell': '8.8', 'Exhausted memory B-cell': '6.1', 'Progenitor cell': '31.0', 'Memory T-reg': '29.0', 'Naive CD4 T-cell activated': '12.6', 'Naive CD8 T-cell activated': '11.8', 'Naive T-reg': '29.8'}
2LE3
{'Adipose Tissue': 37.01503737541528, 'Adrenal Gland': 33.37405426356589, 'Bladder': 31.49857142857143, 'Blood': 14.544809472551131, 'Blood Vessel': 46.10167790262173, 'Brain': 10.551767978803936, 'Breast': 37.11941394335512, 'Cervix Uteri': 39.897368421052626, 'Colon': 51.68364184852375, 'Esophagus': 38.79905951557094, 'Fallopian Tube': 41.73555555555556, 'Heart': 14.347479674796748, 'Kidney': 27.542651685393256, 'Liver': 34.798570796460176, 'Lung': 37.529529411764706, 'Muscle': 6.788332378580323, 'Nerve': 43.557576736672054, 'Ovary': 34.242666666666665, 'Pancreas': 11.883567073170733, 'Pituitary': 24.662081272084805, 'Prostate': 27.18645306122449, 'Salivary Gland': 24.501666666666665, 'Skin': 24.489121061359867, 'Small Intestine': 42.29048128342246, 'Spleen': 39.53178423236515, 'Stomach': 29.25498328690808, 'Testis': 24.61191135734072, 'Thyroid': 27.580211332312405, 'Uterus': 50.06640845070423, 'Vagina': 32.850256410256414}
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95.02, 92.2, 92.08, 91.86, 89.68, 85.47, 71.78, 71.5, 80.71, 82.82, 92.04, 94.36, 95.25, 96.28, 96.65, 94.7, 96.25, 96.3, 94.05, 95.95, 97.93, 98.43, 97.95, 98.52, 98.63, 98.22, 98.17, 98.17, 97.53, 97.26, 93.94, 93.29, 97.73, 96.75, 96.76, 97.27, 96.91, 94.06, 85.94, 87.09, 95.49, 95.08, 98.28, 98.83, 98.89, 98.94, 98.8, 98.72, 97.74, 98.29, 98.55, 98.78, 98.84, 98.72, 98.7, 97.48, 96.91, 93.51, 90.62, 85.91, 85.99, 91.33, 94.5, 96.85, 97.84, 98.3, 98.32, 98.28, 98.56, 98.72, 98.52, 98.71, 98.83, 98.69, 98.45, 98.78, 98.69, 98.29, 98.04, 96.82, 96.74, 97.29, 97.87, 97.89, 97.71, 97.53, 98.51, 98.21, 98.42, 98.7, 98.43, 98.65, 98.69, 98.6, 98.29, 96.41, 97.81, 98.1, 98.47, 98.27, 98.36, 98.53, 98.51, 98.13, 97.93, 97.78, 98.05, 98.2, 98.09, 94.47, 94.98, 96.37, 95.84, 98.11, 98.2, 98.24, 98.66, 98.61, 98.35, 98.6, 98.72, 98.43, 98.28, 98.76, 98.58, 98.8, 98.9, 98.95, 98.89, 98.91, 98.57, 97.66, 97.91, 97.5, 97.39, 95.68, 95.1, 94.67, 91.75, 95.94, 96.0, 94.4, 95.39, 97.26, 97.64, 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98.27, 96.27, 94.79, 91.49, 87.79, 90.88, 91.93, 93.97, 96.92, 96.69, 98.31, 98.53, 98.76, 98.74, 98.64, 98.31, 98.23, 97.45, 97.76, 96.17, 96.53, 98.03, 98.43, 98.61, 98.45, 98.45, 98.71, 98.47, 98.53, 98.69, 98.72, 98.32, 98.18, 98.57, 98.13, 97.27, 96.94, 97.86, 96.14, 95.08, 95.93, 94.77, 89.78, 84.68, 72.33, 63.38, 57.55, 57.08, 49.44, 36.35]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
92.267995
0.276598
794
O60260
P50991
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
CCT4
MPENVAPRSGATAGAAGGRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVNLNGSGKLLKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVNTR
Homo sapiens
Cytoplasm, Melanosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, cilium basal body
Low tissue specificity
{'Ciliated cells': '118.7', 'Basal respiratory cells': '192.5', 'Club cells': '104.2', 'Ionocytes': '132.9', 'Mucus glandular cells': '74.3', 'Serous glandular cells': '97.7', 'Gastric mucus-secreting cells': '66.0', 'Proximal enterocytes': '63.3', 'Paneth cells': '56.8', 'Distal enterocytes': '47.4', 'Intestinal goblet cells': '76.8', 'Exocrine glandular cells': '-0.658', 'Basal prostatic cells': '90.8', 'Prostatic glandular cells': '94.2', 'Breast glandular cells': '0.287', 'Breast myoepithelial cells': '0.192', 'Glandular and luminal cells': '101.3', 'Secretory cells': '174.6', 'Basal keratinocytes': '151.4', 'Suprabasal keratinocytes': '165.2', 'Basal squamous epithelial cells': '144.9', 'Squamous epithelial cells': '144.7', 'Alveolar cells type 1': '-0.102', 'Alveolar cells type 2': '-0.106', 'Salivary duct cells': '86.1', 'Ductal cells': '0.437', 'Hepatocytes': '0.523', 'Cholangiocytes': '83.9', 'Proximal tubular cells': '0.268', 'Distal tubular cells': '144.5', 'Collecting duct cells': '72.0', 'Mesothelial cells': '0.151', 'Sertoli cells': '0.034', 'Granulosa cells': '169.6', 'Enteroendocrine cells': '81.7', 'Pancreatic endocrine cells': '185.1', 'Leydig cells': '0.034', 'Excitatory neurons': '27.0', 'Inhibitory neurons': '30.0', 'Cone photoreceptor cells': '62.9', 'Rod photoreceptor cells': '51.2', 'Bipolar cells': '48.9', 'Horizontal cells': '29.0', 'Astrocytes': '19.8', 'Oligodendrocyte precursor cells': '25.0', 'Oligodendrocytes': '38.0', 'Microglial cells': '28.6', 'Muller glia cells': '61.1', 'Schwann cells': '0.026', 'Spermatogonia': '0.508', 'Spermatocytes': '0.695', 'Early spermatids': '0.447', 'Late spermatids': '0.036', 'Oocytes': '233.8', 'Cytotrophoblasts': '269.1', 'Syncytiotrophoblasts': '176.8', 'Extravillous trophoblasts': '285.6', 'Endothelial cells': '114.5', 'Lymphatic endothelial cells': '108.8', 'Cardiomyocytes': '0.600', 'Skeletal myocytes': '-0.210', 'Smooth muscle cells': '110.4', 'Adipocytes': '109.2', 'Melanocytes': '0.111', 'Fibroblasts': '110.2', 'Peritubular cells': '-0.064', 'Endometrial stromal cells': '119.0', 'Ovarian stromal cells': '209.5', 'Undifferentiated cells': '154.0', 'T-cells': '121.7', 'B-cells': '110.4', 'Plasma cells': '129.6', 'Nk-cells': '84.7', 'Granulocytes': '116.2', 'Monocytes': '116.4', 'Macrophages': '101.6', 'Hofbauer cells': '151.0', 'Kupffer cells': '98.6', 'Dendritic cells': '90.9', 'Langerhans cells': '0.177', 'Erythroid cells': '-0.106', 'Adipocytes (Subcutaneous)': '0.018', 'Adipocytes (Visceral)': '-0.106', 'Breast glandular cells (progenitors)': '0.335', 'Adipocytes (Breast)': '-0.153', 'Colon enterocytes': '-0.186', 'Colon enteroendocrine cells': '0.159', 'Enteric glia cells': '-0.114', 'Mitotic cells (Colon)': '-0.103', 'Mitotic cells (Heart)': '0.504', 'Podocytes': '0.047', 'Ascending Loop of Henle cells': '0.376', 'Intercalated cells': '0.060', 'Cholangiocyte': '0.384', 'NK-cells (Liver)': '-0.388', 'Respiratory ciliated cells': '-0.014', 'Mitotic cells (Lung)': '0.128', 'NK-cells (Lung)': '-0.075', 'B-cells (Lung)': '-0.119', 'Alpha cells': '0.235', 'Beta cells': '0.088', 'Prostate glandular cells': '-0.167', 'Prostate basal glandular cells': '0.067', 'Urothelial cells': '0.046', 'Keratinocyte (other)': '0.227', 'Keratinocyte (granular)': '-0.101', 'Hair cortex cells': '0.036', 'Inner root sheath cells': '0.132', 'Outer root sheath cells': '0.129', 'Sebaceous gland cells': '0.108', 'Eccrine sweat gland cells': '0.020', 'Adipocytes (Skin)': '-0.047', 'Mitotic cells (Skin)': '0.348', 'Parietal cells': '-0.576', 'Chief cells': '-0.347', 'Gastric mucous cells': '-0.385', 'Gastric enteroendocrine cells': '-0.332', 'Mitotic cells (Stomach)': '0.063', 'Parafollicular cells': '0.073', 'Thyroid glandular cells': '0.357', 'Mitotic cells (Thyroid)': '0.052', 'Adrenal cortex cells': '0.412', 'Adrenal medulla cells': '-0.019', 'Mitotic cells (Adrenal gland)': '0.345', 'Minor salivary glandular cells': '0.410', 'Minor salivary gland ductal cells': '-0.105', 'Minor salivary gland basal cells': '0.452', 'Mitotic cells (Minor salivary gland)': '0.563', 'Adipocytes (Minor salivary gland)': '0.195', 'Somatotropes': '0.096', 'Lactotropes': '0.067', 'Gonadotropes': '-0.027', 'Corticotropes': '0.064', 'Thyrotropes': '0.173', 'Undifferentiated cells (Pituitary gland)': '0.127', 'Mitotic cells (Spleen)': '0.059', 'Platelets': '-0.068', 'Erythrocytes': '-0.087', 'Hematopoietic stem cells': '-0.099', 'B-cells (Spleen)': '0.234', 'NK-cells (Spleen)': '0.045', 'Amygdala excitatory': '40.5', 'Cerebellar inhibitory': '54.2', 'Cge interneuron': '52.5', 'Deep-layer corticothalamic and 6b': '42.2', 'Deep-layer intratelencephalic': '44.2', 'Deep-layer near-projecting': '53.3', 'Eccentric medium spiny neuron': '41.0', 'Hippocampal ca1-3': '34.3', 'Hippocampal ca4': '45.0', 'Hippocampal dentate gyrus': '57.3', 'Lamp5-lhx6 and chandelier': '51.9', 'Lower rhombic lip': '43.9', 'Mammillary body': '41.3', 'Medium spiny neuron': '36.9', 'Mge interneuron': '46.6', 'Midbrain-derived inhibitory': '45.2', 'Miscellaneous': '42.9', 'Splatter': '49.1', 'Thalamic excitatory': '44.4', 'Upper rhombic lip': '47.9', 'Upper-layer intratelencephalic': '46.3', 'Astrocyte': '35.7', 'Bergmann glia': '44.2', 'Central nervous system macrophage': '70.9', 'Choroid plexus epithelial cell': '74.0', 'Committed oligodendrocyte precursor': '52.6', 'Ependymal cell': '61.0', 'Oligodendrocyte': '70.1', 'Oligodendrocyte precursor cell': '50.9', 'Endothelial cell': '71.2', 'Pericyte': '66.7', 'Vascular associated smooth muscle cell': '58.6', 'Fibroblast': '52.7', 'Leukocyte': '91.3', 'Basophil': '49.8', 'Eosinophil': '25.1', 'Neutrophil': '10.0', 'Classical monocyte': '73.5', 'Non-classical monocyte': '116.1', 'Intermediate monocyte': '154.3', 'T-reg': '146.7', 'GdT-cell': '83.3', 'MAIT T-cell': '166.8', 'Memory CD4 T-cell': '87.3', 'Naive CD4 T-cell': '180.6', 'Memory CD8 T-cell': '100.8', 'Naive CD8 T-cell': '154.2', 'Memory B-cell': '93.9', 'Naive B-cell': '94.7', 'Plasmacytoid DC': '210.2', 'Myeloid DC': '189.9', 'NK-cell': '113.1', 'Total PBMC': '136.8', 'Vd2 gdTCR': '146.6', 'Memory CD4 T-cell Th1\\/Th17': '155.2', 'Memory CD4 T-cell Th17': '152.2', 'Memory CD4 T-cell Th2': '150.5', 'Non-Vd2 gdTCR': '132.1', 'Memory CD4 T-cell Th1': '133.9', 'Memory CD4 T-cell TFH': '137.6', 'Terminal effector memory CD4 T-cell': '147.9', 'Central memory CD8 T-cell': '143.1', 'Effector memory CD8 T-cell': '155.9', 'Terminal effector memory CD8 T-cell': '137.9', 'Non-switched memory B-cell': '128.8', 'Plasmablast': '232.2', 'Switched memory B-cell': '160.1', 'Exhausted memory B-cell': '130.8', 'Progenitor cell': '195.0', 'Memory T-reg': '127.7', 'Naive CD4 T-cell activated': '526.2', 'Naive CD8 T-cell activated': '502.2', 'Naive T-reg': '164.9'}
6NR8, 6NR9, 6NRA, 6NRB, 6NRC, 6NRD, 6QB8, 7LUM, 7LUP, 7NVL, 7NVM, 7NVN, 7NVO, 7TRG, 7TTN, 7TTT, 7TUB, 7WU7, 7WZ3, 7X0A, 7X0S, 7X0V, 7X3J, 7X3U, 7X6Q, 7X7Y, 8HKI, 8I1U, 8I9Q, 8I9U, 8IB8, 8SFE, 8SFF, 8SG8, 8SG9, 8SGC, 8SGL, 8SGQ, 8SH9, 8SHA, 8SHD, 8SHE, 8SHF, 8SHG, 8SHL, 8SHN, 8SHO, 8SHP, 8SHQ, 8SHT
{'Adipose Tissue': 111.03912790697672, 'Adrenal Gland': 97.15201550387596, 'Bladder': 125.04904761904764, 'Blood': 78.06655651237891, 'Blood Vessel': 121.37791011235956, 'Brain': 65.84557456472369, 'Breast': 114.45956427015253, 'Cervix Uteri': 153.36315789473684, 'Colon': 101.0660590500642, 'Esophagus': 107.82632525951556, 'Fallopian Tube': 152.6888888888889, 'Heart': 51.18525667828107, 'Kidney': 58.40471910112359, 'Liver': 39.24047345132743, 'Lung': 104.03572664359862, 'Muscle': 78.8247198007472, 'Nerve': 115.6162843295638, 'Ovary': 194.66644444444444, 'Pancreas': 64.40612804878049, 'Pituitary': 89.18095406360423, 'Prostate': 90.50465306122447, 'Salivary Gland': 81.44117283950617, 'Skin': 149.34867330016584, 'Small Intestine': 83.36224598930481, 'Spleen': 93.38236514522822, 'Stomach': 87.98359331476323, 'Testis': 148.138891966759, 'Thyroid': 105.83012251148546, 'Uterus': 159.49422535211266, 'Vagina': 122.79833333333332}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
88.779555
0.318089
1,449
O60260
P51648
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ALDH3A2
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY
Homo sapiens
Microsome membrane, Endoplasmic reticulum membrane
Tissue enhanced (liver)
{'Ciliated cells': '51.7', 'Basal respiratory cells': '86.7', 'Club cells': '60.8', 'Ionocytes': '39.4', 'Mucus glandular cells': '61.9', 'Serous glandular cells': '70.0', 'Gastric mucus-secreting cells': '84.9', 'Proximal enterocytes': '95.8', 'Paneth cells': '25.7', 'Distal enterocytes': '48.7', 'Intestinal goblet cells': '25.3', 'Exocrine glandular cells': '-0.702', 'Basal prostatic cells': '46.2', 'Prostatic glandular cells': '145.5', 'Breast glandular cells': '0.128', 'Breast myoepithelial cells': '0.059', 'Glandular and luminal cells': '38.1', 'Secretory cells': '28.2', 'Basal keratinocytes': '128.9', 'Suprabasal keratinocytes': '156.0', 'Basal squamous epithelial cells': '281.7', 'Squamous epithelial cells': '221.7', 'Alveolar cells type 1': '0.586', 'Alveolar cells type 2': '0.167', 'Salivary duct cells': '150.8', 'Ductal cells': '0.758', 'Hepatocytes': '0.691', 'Cholangiocytes': '112.6', 'Proximal tubular cells': '0.362', 'Distal tubular cells': '33.8', 'Collecting duct cells': '25.3', 'Mesothelial cells': '0.443', 'Sertoli cells': '0.573', 'Granulosa cells': '24.6', 'Enteroendocrine cells': '25.4', 'Pancreatic endocrine cells': '56.0', 'Leydig cells': '0.780', 'Excitatory neurons': '29.5', 'Inhibitory neurons': '19.2', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '33.7', 'Bipolar cells': '24.8', 'Horizontal cells': '20.1', 'Astrocytes': '13.9', 'Oligodendrocyte precursor cells': '18.4', 'Oligodendrocytes': '27.1', 'Microglial cells': '12.5', 'Muller glia cells': '95.4', 'Schwann cells': '-0.071', 'Spermatogonia': '0.479', 'Spermatocytes': '0.168', 'Early spermatids': '-0.462', 'Late spermatids': '-0.701', 'Oocytes': '22.8', 'Cytotrophoblasts': '13.8', 'Syncytiotrophoblasts': '1.4', 'Extravillous trophoblasts': '3.7', 'Endothelial cells': '27.5', 'Lymphatic endothelial cells': '42.1', 'Cardiomyocytes': '0.666', 'Skeletal myocytes': '-0.070', 'Smooth muscle cells': '29.5', 'Adipocytes': '23.2', 'Melanocytes': '0.324', 'Fibroblasts': '39.8', 'Peritubular cells': '0.519', 'Endometrial stromal cells': '14.2', 'Ovarian stromal cells': '35.2', 'Undifferentiated cells': '45.8', 'T-cells': '15.8', 'B-cells': '9.9', 'Plasma cells': '29.1', 'Nk-cells': '11.8', 'Granulocytes': '34.4', 'Monocytes': '21.5', 'Macrophages': '29.4', 'Hofbauer cells': '26.7', 'Kupffer cells': '27.7', 'Dendritic cells': '1.2', 'Langerhans cells': '0.469', 'Erythroid cells': '-0.099', 'Adipocytes (Subcutaneous)': '0.335', 'Adipocytes (Visceral)': '0.196', 'Breast glandular cells (progenitors)': '-0.044', 'Adipocytes (Breast)': '0.159', 'Colon enterocytes': '-0.110', 'Colon enteroendocrine cells': '0.191', 'Enteric glia cells': '0.005', 'Mitotic cells (Colon)': '-0.083', 'Mitotic cells (Heart)': '0.511', 'Podocytes': '0.106', 'Ascending Loop of Henle cells': '0.417', 'Intercalated cells': '0.259', 'Cholangiocyte': '0.013', 'NK-cells (Liver)': '0.084', 'Respiratory ciliated cells': '0.109', 'Mitotic cells (Lung)': '-0.061', 'NK-cells (Lung)': '0.228', 'B-cells (Lung)': '-0.043', 'Alpha cells': '0.396', 'Beta cells': '0.232', 'Prostate glandular cells': '0.569', 'Prostate basal glandular cells': '0.640', 'Urothelial cells': '0.101', 'Keratinocyte (other)': '0.753', 'Keratinocyte (granular)': '0.247', 'Hair cortex cells': '-0.290', 'Inner root sheath cells': '-0.262', 'Outer root sheath cells': '-0.208', 'Sebaceous gland cells': '0.018', 'Eccrine sweat gland cells': '-0.459', 'Adipocytes (Skin)': '-0.444', 'Mitotic cells (Skin)': '0.281', 'Parietal cells': '-0.027', 'Chief cells': '-0.117', 'Gastric mucous cells': '0.341', 'Gastric enteroendocrine cells': '-0.025', 'Mitotic cells (Stomach)': '0.397', 'Parafollicular cells': '0.160', 'Thyroid glandular cells': '0.386', 'Mitotic cells (Thyroid)': '-0.046', 'Adrenal cortex cells': '0.510', 'Adrenal medulla cells': '0.006', 'Mitotic cells (Adrenal gland)': '0.214', 'Minor salivary glandular cells': '0.195', 'Minor salivary gland ductal cells': '-0.207', 'Minor salivary gland basal cells': '0.422', 'Mitotic cells (Minor salivary gland)': '0.406', 'Adipocytes (Minor salivary gland)': '0.118', 'Somatotropes': '-0.281', 'Lactotropes': '-0.243', 'Gonadotropes': '0.146', 'Corticotropes': '-0.190', 'Thyrotropes': '0.035', 'Undifferentiated cells (Pituitary gland)': '0.567', 'Mitotic cells (Spleen)': '-0.313', 'Platelets': '-0.130', 'Erythrocytes': '-0.072', 'Hematopoietic stem cells': '-0.216', 'B-cells (Spleen)': '0.188', 'NK-cells (Spleen)': '0.349', 'Amygdala excitatory': '42.4', 'Cerebellar inhibitory': '26.4', 'Cge interneuron': '31.2', 'Deep-layer corticothalamic and 6b': '40.0', 'Deep-layer intratelencephalic': '38.5', 'Deep-layer near-projecting': '12.5', 'Eccentric medium spiny neuron': '81.2', 'Hippocampal ca1-3': '40.8', 'Hippocampal ca4': '50.5', 'Hippocampal dentate gyrus': '110.1', 'Lamp5-lhx6 and chandelier': '23.7', 'Lower rhombic lip': '16.2', 'Mammillary body': '41.5', 'Medium spiny neuron': '102.7', 'Mge interneuron': '32.5', 'Midbrain-derived inhibitory': '26.9', 'Miscellaneous': '39.1', 'Splatter': '27.7', 'Thalamic excitatory': '38.1', 'Upper rhombic lip': '35.9', 'Upper-layer intratelencephalic': '44.7', 'Astrocyte': '30.3', 'Bergmann glia': '23.2', 'Central nervous system macrophage': '26.3', 'Choroid plexus epithelial cell': '138.1', 'Committed oligodendrocyte precursor': '35.7', 'Ependymal cell': '74.1', 'Oligodendrocyte': '42.0', 'Oligodendrocyte precursor cell': '36.4', 'Endothelial cell': '21.6', 'Pericyte': '28.4', 'Vascular associated smooth muscle cell': '31.9', 'Fibroblast': '79.3', 'Leukocyte': '21.7', 'Basophil': '27.0', 'Eosinophil': '17.6', 'Neutrophil': '5.5', 'Classical monocyte': '32.6', 'Non-classical monocyte': '32.6', 'Intermediate monocyte': '71.6', 'T-reg': '33.5', 'GdT-cell': '6.3', 'MAIT T-cell': '28.2', 'Memory CD4 T-cell': '6.1', 'Naive CD4 T-cell': '44.1', 'Memory CD8 T-cell': '6.1', 'Naive CD8 T-cell': '38.2', 'Memory B-cell': '5.2', 'Naive B-cell': '19.6', 'Plasmacytoid DC': '6.8', 'Myeloid DC': '64.0', 'NK-cell': '31.9', 'Total PBMC': '41.6', 'Vd2 gdTCR': '27.3', 'Memory CD4 T-cell Th1\\/Th17': '27.9', 'Memory CD4 T-cell Th17': '28.9', 'Memory CD4 T-cell Th2': '31.3', 'Non-Vd2 gdTCR': '31.4', 'Memory CD4 T-cell Th1': '30.6', 'Memory CD4 T-cell TFH': '31.6', 'Terminal effector memory CD4 T-cell': '23.5', 'Central memory CD8 T-cell': '32.8', 'Effector memory CD8 T-cell': '22.9', 'Terminal effector memory CD8 T-cell': '23.4', 'Non-switched memory B-cell': '31.4', 'Plasmablast': '97.3', 'Switched memory B-cell': '22.6', 'Exhausted memory B-cell': '24.4', 'Progenitor cell': '20.6', 'Memory T-reg': '43.4', 'Naive CD4 T-cell activated': '5.4', 'Naive CD8 T-cell activated': '5.3', 'Naive T-reg': '45.3'}
4QGK
{'Adipose Tissue': 47.08424584717608, 'Adrenal Gland': 211.0363953488372, 'Bladder': 38.82476190476191, 'Blood': 7.861768675995694, 'Blood Vessel': 58.30677902621723, 'Brain': 24.00445420136261, 'Breast': 41.45655773420479, 'Cervix Uteri': 62.63263157894737, 'Colon': 42.2816431322208, 'Esophagus': 76.4262, 'Fallopian Tube': 46.81777777777778, 'Heart': 14.77122299651568, 'Kidney': 35.07743820224719, 'Liver': 63.14685840707965, 'Lung': 63.108131487889274, 'Muscle': 34.70716936488169, 'Nerve': 59.464878836833606, 'Ovary': 50.24166666666667, 'Pancreas': 28.1966006097561, 'Pituitary': 46.14770318021201, 'Prostate': 84.9313469387755, 'Salivary Gland': 93.66771604938272, 'Skin': 126.0328192371476, 'Small Intestine': 39.626844919786095, 'Spleen': 25.899327800829877, 'Stomach': 37.11504178272981, 'Testis': 36.88168975069252, 'Thyroid': 78.96084226646248, 'Uterus': 47.9519014084507, 'Vagina': 81.73185897435897}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
96.705155
0.295876
1,637
O60260
P51955
26387737
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
NEK2
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
Homo sapiens
Nucleus, Nucleus, nucleolus, Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle pole, Chromosome, centromere, kinetochore, Chromosome, centromere, Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Group enriched (bone marrow, lymphoid tissue, testis)
{'Ciliated cells': '12.6', 'Basal respiratory cells': '3.6', 'Club cells': '1.9', 'Ionocytes': '1.5', 'Mucus glandular cells': '1.3', 'Serous glandular cells': '0.1', 'Gastric mucus-secreting cells': '5.9', 'Proximal enterocytes': '1.9', 'Paneth cells': '2.6', 'Distal enterocytes': '0.8', 'Intestinal goblet cells': '3.3', 'Exocrine glandular cells': '-0.118', 'Basal prostatic cells': '0.0', 'Prostatic glandular cells': '0.0', 'Breast glandular cells': '0.211', 'Breast myoepithelial cells': '0.249', 'Glandular and luminal cells': '1.6', 'Secretory cells': '0.4', 'Basal keratinocytes': '4.7', 'Suprabasal keratinocytes': '2.7', 'Basal squamous epithelial cells': '2.9', 'Squamous epithelial cells': '7.6', 'Alveolar cells type 1': '-0.230', 'Alveolar cells type 2': '0.117', 'Salivary duct cells': '1.4', 'Ductal cells': '0.279', 'Hepatocytes': '0.303', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.270', 'Distal tubular cells': '0.0', 'Collecting duct cells': '0.0', 'Mesothelial cells': '0.051', 'Sertoli cells': '-0.371', 'Granulosa cells': '1.1', 'Enteroendocrine cells': '0.9', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '-0.380', 'Excitatory neurons': '0.7', 'Inhibitory neurons': '0.0', 'Cone photoreceptor cells': '3.4', 'Rod photoreceptor cells': '2.3', 'Bipolar cells': '11.2', 'Horizontal cells': '0.6', 'Astrocytes': '0.3', 'Oligodendrocyte precursor cells': '0.0', 'Oligodendrocytes': '0.1', 'Microglial cells': '0.0', 'Muller glia cells': '1.3', 'Schwann cells': '0.088', 'Spermatogonia': '-0.081', 'Spermatocytes': '0.429', 'Early spermatids': '0.899', 'Late spermatids': '0.461', 'Oocytes': '19.9', 'Cytotrophoblasts': '9.8', 'Syncytiotrophoblasts': '0.9', 'Extravillous trophoblasts': '14.8', 'Endothelial cells': '0.4', 'Lymphatic endothelial cells': '0.1', 'Cardiomyocytes': '0.176', 'Skeletal myocytes': '-0.023', 'Smooth muscle cells': '0.7', 'Adipocytes': '0.1', 'Melanocytes': '0.431', 'Fibroblasts': '1.2', 'Peritubular cells': '-0.298', 'Endometrial stromal cells': '0.5', 'Ovarian stromal cells': '0.1', 'Undifferentiated cells': '19.0', 'T-cells': '1.6', 'B-cells': '0.3', 'Plasma cells': '7.5', 'Nk-cells': '1.5', 'Granulocytes': '0.0', 'Monocytes': '0.0', 'Macrophages': '1.6', 'Hofbauer cells': '4.4', 'Kupffer cells': '1.9', 'Dendritic cells': '0.0', 'Langerhans cells': '0.134', 'Erythroid cells': '0.097', 'Adipocytes (Subcutaneous)': '-0.122', 'Adipocytes (Visceral)': '-0.158', 'Breast glandular cells (progenitors)': '0.218', 'Adipocytes (Breast)': '-0.158', 'Colon enterocytes': '0.372', 'Colon enteroendocrine cells': '-0.161', 'Enteric glia cells': '-0.178', 'Mitotic cells (Colon)': '0.681', 'Mitotic cells (Heart)': '0.703', 'Podocytes': '-0.125', 'Ascending Loop of Henle cells': '0.226', 'Intercalated cells': '-0.069', 'Cholangiocyte': '0.299', 'NK-cells (Liver)': '-0.175', 'Respiratory ciliated cells': '0.251', 'Mitotic cells (Lung)': '0.793', 'NK-cells (Lung)': '-0.108', 'B-cells (Lung)': '0.041', 'Alpha cells': '0.098', 'Beta cells': '0.026', 'Prostate glandular cells': '-0.030', 'Prostate basal glandular cells': '0.228', 'Urothelial cells': '0.247', 'Keratinocyte (other)': '0.299', 'Keratinocyte (granular)': '-0.174', 'Hair cortex cells': '0.043', 'Inner root sheath cells': '0.206', 'Outer root sheath cells': '0.198', 'Sebaceous gland cells': '0.019', 'Eccrine sweat gland cells': '-0.045', 'Adipocytes (Skin)': '-0.187', 'Mitotic cells (Skin)': '0.869', 'Parietal cells': '0.243', 'Chief cells': '0.154', 'Gastric mucous cells': '0.611', 'Gastric enteroendocrine cells': '0.257', 'Mitotic cells (Stomach)': '0.894', 'Parafollicular cells': '-0.024', 'Thyroid glandular cells': '-0.093', 'Mitotic cells (Thyroid)': '0.672', 'Adrenal cortex cells': '0.565', 'Adrenal medulla cells': '0.101', 'Mitotic cells (Adrenal gland)': '0.870', 'Minor salivary glandular cells': '0.088', 'Minor salivary gland ductal cells': '-0.300', 'Minor salivary gland basal cells': '0.642', 'Mitotic cells (Minor salivary gland)': '0.916', 'Adipocytes (Minor salivary gland)': '0.150', 'Somatotropes': '-0.067', 'Lactotropes': '0.002', 'Gonadotropes': '0.002', 'Corticotropes': '-0.097', 'Thyrotropes': '0.035', 'Undifferentiated cells (Pituitary gland)': '0.260', 'Mitotic cells (Spleen)': '0.919', 'Platelets': '0.175', 'Erythrocytes': '0.330', 'Hematopoietic stem cells': '0.389', 'B-cells (Spleen)': '-0.134', 'NK-cells (Spleen)': '-0.201', 'Amygdala excitatory': '0.9', 'Cerebellar inhibitory': '0.1', 'Cge interneuron': '0.0', 'Deep-layer corticothalamic and 6b': '0.3', 'Deep-layer intratelencephalic': '0.4', 'Deep-layer near-projecting': '0.1', 'Eccentric medium spiny neuron': '0.1', 'Hippocampal ca1-3': '0.9', 'Hippocampal ca4': '2.6', 'Hippocampal dentate gyrus': '0.3', 'Lamp5-lhx6 and chandelier': '0.0', 'Lower rhombic lip': '0.0', 'Mammillary body': '0.1', 'Medium spiny neuron': '0.2', 'Mge interneuron': '0.1', 'Midbrain-derived inhibitory': '0.2', 'Miscellaneous': '1.2', 'Splatter': '0.0', 'Thalamic excitatory': '0.0', 'Upper rhombic lip': '0.0', 'Upper-layer intratelencephalic': '1.9', 'Astrocyte': '0.1', 'Bergmann glia': '0.0', 'Central nervous system macrophage': '0.1', 'Choroid plexus epithelial cell': '0.1', 'Committed oligodendrocyte precursor': '0.1', 'Ependymal cell': '2.5', 'Oligodendrocyte': '0.1', 'Oligodendrocyte precursor cell': '0.0', 'Endothelial cell': '0.3', 'Pericyte': '0.2', 'Vascular associated smooth muscle cell': '0.0', 'Fibroblast': '0.0', 'Leukocyte': '0.2', 'Basophil': '1.4', 'Eosinophil': '0.1', 'Neutrophil': '0.8', 'Classical monocyte': '0.1', 'Non-classical monocyte': '0.3', 'Intermediate monocyte': '1.3', 'T-reg': '2.7', 'GdT-cell': '0.1', 'MAIT T-cell': '2.3', 'Memory CD4 T-cell': '0.1', 'Naive CD4 T-cell': '0.2', 'Memory CD8 T-cell': '0.0', 'Naive CD8 T-cell': '0.2', 'Memory B-cell': '0.4', 'Naive B-cell': '0.2', 'Plasmacytoid DC': '1.5', 'Myeloid DC': '0.9', 'NK-cell': '1.1', 'Total PBMC': '2.0', 'Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1\\/Th17': '0.3', 'Memory CD4 T-cell Th17': '0.3', 'Memory CD4 T-cell Th2': '0.4', 'Non-Vd2 gdTCR': '0.6', 'Memory CD4 T-cell Th1': '0.5', 'Memory CD4 T-cell TFH': '0.3', 'Terminal effector memory CD4 T-cell': '3.0', 'Central memory CD8 T-cell': '0.7', 'Effector memory CD8 T-cell': '2.0', 'Terminal effector memory CD8 T-cell': '7.1', 'Non-switched memory B-cell': '1.6', 'Plasmablast': '10.8', 'Switched memory B-cell': '2.1', 'Exhausted memory B-cell': '3.4', 'Progenitor cell': '1.0', 'Memory T-reg': '1.5', 'Naive CD4 T-cell activated': '0.2', 'Naive CD8 T-cell activated': '0.2', 'Naive T-reg': '0.4'}
2JAV, 2W5A, 2W5B, 2W5H, 2WQO, 2XK3, 2XK4, 2XK6, 2XK7, 2XK8, 2XKC, 2XKD, 2XKE, 2XKF, 2XNM, 2XNN, 2XNO, 2XNP, 4A4X, 4AFE, 5M51, 5M53, 5M55, 5M57, 6SGD, 6SGH, 6SGI, 6SGK, 6SK9, 6TM5
{'Adipose Tissue': 0.2941280764119601, 'Adrenal Gland': 0.5505113953488372, 'Bladder': 0.3633128571428571, 'Blood': 6.112617395048439, 'Blood Vessel': 0.2202123468164794, 'Brain': 0.3218959012112036, 'Breast': 0.3114407843137255, 'Cervix Uteri': 0.6535378947368421, 'Colon': 1.401818947368421, 'Esophagus': 1.9859257321799308, 'Fallopian Tube': 0.7061977777777778, 'Heart': 0.0997872427409988, 'Kidney': 0.2768461460674157, 'Liver': 0.3346117610619469, 'Lung': 0.9649078546712802, 'Muscle': 0.0381335753424657, 'Nerve': 0.1753720678513732, 'Ovary': 0.1841848333333333, 'Pancreas': 0.0880934329268292, 'Pituitary': 0.1405846996466431, 'Prostate': 0.3417389387755102, 'Salivary Gland': 0.9480614814814816, 'Skin': 6.4150762631288005, 'Small Intestine': 2.7855332085561497, 'Spleen': 1.877317510373444, 'Stomach': 1.0238363231197771, 'Testis': 54.86052354570637, 'Thyroid': 0.2566656508422664, 'Uterus': 0.1818593661971831, 'Vagina': 2.355875192307692}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
78.253528
0.45427
1,785
O60260
P52597
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
HNRNPF
MMLGPEGGEGFVVKLRGLPWSCSVEDVQNFLSDCTIHDGAAGVHFIYTREGRQSGEAFVELGSEDDVKMALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLERMRPGAYSTGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD
Homo sapiens
Nucleus, nucleoplasm
Low tissue specificity
{'Ciliated cells': '241.6', 'Basal respiratory cells': '190.0', 'Club cells': '148.1', 'Ionocytes': '137.3', 'Mucus glandular cells': '107.2', 'Serous glandular cells': '81.1', 'Gastric mucus-secreting cells': '156.8', 'Proximal enterocytes': '178.8', 'Paneth cells': '156.9', 'Distal enterocytes': '141.2', 'Intestinal goblet cells': '190.6', 'Exocrine glandular cells': '-0.788', 'Basal prostatic cells': '132.8', 'Prostatic glandular cells': '119.4', 'Breast glandular cells': '0.395', 'Breast myoepithelial cells': '0.290', 'Glandular and luminal cells': '153.7', 'Secretory cells': '231.4', 'Basal keratinocytes': '260.4', 'Suprabasal keratinocytes': '228.7', 'Basal squamous epithelial cells': '203.4', 'Squamous epithelial cells': '201.0', 'Alveolar cells type 1': '0.120', 'Alveolar cells type 2': '0.140', 'Salivary duct cells': '105.6', 'Ductal cells': '0.635', 'Hepatocytes': '0.569', 'Cholangiocytes': '156.4', 'Proximal tubular cells': '0.319', 'Distal tubular cells': '159.8', 'Collecting duct cells': '107.0', 'Mesothelial cells': '0.011', 'Sertoli cells': '-0.204', 'Granulosa cells': '117.0', 'Enteroendocrine cells': '143.0', 'Pancreatic endocrine cells': '130.7', 'Leydig cells': '-0.143', 'Excitatory neurons': '10.4', 'Inhibitory neurons': '11.5', 'Cone photoreceptor cells': '96.9', 'Rod photoreceptor cells': '127.8', 'Bipolar cells': '60.6', 'Horizontal cells': '22.7', 'Astrocytes': '12.7', 'Oligodendrocyte precursor cells': '15.6', 'Oligodendrocytes': '30.4', 'Microglial cells': '23.3', 'Muller glia cells': '107.0', 'Schwann cells': '0.097', 'Spermatogonia': '0.280', 'Spermatocytes': '0.591', 'Early spermatids': '0.649', 'Late spermatids': '0.302', 'Oocytes': '222.0', 'Cytotrophoblasts': '301.9', 'Syncytiotrophoblasts': '204.3', 'Extravillous trophoblasts': '415.6', 'Endothelial cells': '165.4', 'Lymphatic endothelial cells': '122.5', 'Cardiomyocytes': '0.443', 'Skeletal myocytes': '-0.283', 'Smooth muscle cells': '124.3', 'Adipocytes': '210.7', 'Melanocytes': '0.238', 'Fibroblasts': '142.2', 'Peritubular cells': '-0.162', 'Endometrial stromal cells': '157.4', 'Ovarian stromal cells': '115.9', 'Undifferentiated cells': '251.8', 'T-cells': '213.5', 'B-cells': '186.0', 'Plasma cells': '164.7', 'Nk-cells': '212.4', 'Granulocytes': '162.4', 'Monocytes': '278.4', 'Macrophages': '183.4', 'Hofbauer cells': '221.9', 'Kupffer cells': '160.0', 'Dendritic cells': '148.5', 'Langerhans cells': '0.286', 'Erythroid cells': '-0.137', 'Adipocytes (Subcutaneous)': '-0.117', 'Adipocytes (Visceral)': '-0.080', 'Breast glandular cells (progenitors)': '0.274', 'Adipocytes (Breast)': '-0.340', 'Colon enterocytes': '-0.042', 'Colon enteroendocrine cells': '0.128', 'Enteric glia cells': '-0.241', 'Mitotic cells (Colon)': '0.124', 'Mitotic cells (Heart)': '0.476', 'Podocytes': '-0.014', 'Ascending Loop of Henle cells': '0.284', 'Intercalated cells': '-0.024', 'Cholangiocyte': '0.310', 'NK-cells (Liver)': '-0.377', 'Respiratory ciliated cells': '-0.027', 'Mitotic cells (Lung)': '0.026', 'NK-cells (Lung)': '0.032', 'B-cells (Lung)': '-0.119', 'Alpha cells': '0.308', 'Beta cells': '0.127', 'Prostate glandular cells': '0.030', 'Prostate basal glandular cells': '0.272', 'Urothelial cells': '0.208', 'Keratinocyte (other)': '0.459', 'Keratinocyte (granular)': '0.111', 'Hair cortex cells': '-0.153', 'Inner root sheath cells': '-0.054', 'Outer root sheath cells': '-0.070', 'Sebaceous gland cells': '-0.066', 'Eccrine sweat gland cells': '-0.201', 'Adipocytes (Skin)': '-0.263', 'Mitotic cells (Skin)': '0.280', 'Parietal cells': '-0.427', 'Chief cells': '-0.335', 'Gastric mucous cells': '-0.041', 'Gastric enteroendocrine cells': '-0.224', 'Mitotic cells (Stomach)': '0.338', 'Parafollicular cells': '0.047', 'Thyroid glandular cells': '0.183', 'Mitotic cells (Thyroid)': '0.064', 'Adrenal cortex cells': '0.502', 'Adrenal medulla cells': '0.024', 'Mitotic cells (Adrenal gland)': '0.356', 'Minor salivary glandular cells': '0.581', 'Minor salivary gland ductal cells': '-0.088', 'Minor salivary gland basal cells': '0.421', 'Mitotic cells (Minor salivary gland)': '0.507', 'Adipocytes (Minor salivary gland)': '0.131', 'Somatotropes': '0.035', 'Lactotropes': '-0.287', 'Gonadotropes': '-0.219', 'Corticotropes': '-0.227', 'Thyrotropes': '-0.114', 'Undifferentiated cells (Pituitary gland)': '0.265', 'Mitotic cells (Spleen)': '-0.052', 'Platelets': '-0.055', 'Erythrocytes': '-0.179', 'Hematopoietic stem cells': '-0.141', 'B-cells (Spleen)': '0.291', 'NK-cells (Spleen)': '0.171', 'Amygdala excitatory': '12.1', 'Cerebellar inhibitory': '19.9', 'Cge interneuron': '18.7', 'Deep-layer corticothalamic and 6b': '15.2', 'Deep-layer intratelencephalic': '14.4', 'Deep-layer near-projecting': '17.1', 'Eccentric medium spiny neuron': '17.8', 'Hippocampal ca1-3': '16.0', 'Hippocampal ca4': '13.0', 'Hippocampal dentate gyrus': '16.9', 'Lamp5-lhx6 and chandelier': '18.0', 'Lower rhombic lip': '15.4', 'Mammillary body': '18.7', 'Medium spiny neuron': '16.4', 'Mge interneuron': '18.6', 'Midbrain-derived inhibitory': '20.2', 'Miscellaneous': '14.3', 'Splatter': '15.5', 'Thalamic excitatory': '17.4', 'Upper rhombic lip': '27.0', 'Upper-layer intratelencephalic': '14.5', 'Astrocyte': '24.0', 'Bergmann glia': '35.4', 'Central nervous system macrophage': '69.0', 'Choroid plexus epithelial cell': '68.2', 'Committed oligodendrocyte precursor': '30.4', 'Ependymal cell': '128.4', 'Oligodendrocyte': '42.2', 'Oligodendrocyte precursor cell': '28.0', 'Endothelial cell': '66.8', 'Pericyte': '54.0', 'Vascular associated smooth muscle cell': '55.3', 'Fibroblast': '43.6', 'Leukocyte': '99.8', 'Basophil': '287.9', 'Eosinophil': '224.1', 'Neutrophil': '342.5', 'Classical monocyte': '144.5', 'Non-classical monocyte': '171.1', 'Intermediate monocyte': '479.1', 'T-reg': '441.6', 'GdT-cell': '242.8', 'MAIT T-cell': '468.9', 'Memory CD4 T-cell': '252.5', 'Naive CD4 T-cell': '116.6', 'Memory CD8 T-cell': '268.2', 'Naive CD8 T-cell': '106.3', 'Memory B-cell': '234.9', 'Naive B-cell': '67.9', 'Plasmacytoid DC': '383.2', 'Myeloid DC': '507.3', 'NK-cell': '182.4', 'Total PBMC': '420.6', 'Vd2 gdTCR': '447.7', 'Memory CD4 T-cell Th1\\/Th17': '150.4', 'Memory CD4 T-cell Th17': '170.8', 'Memory CD4 T-cell Th2': '168.0', 'Non-Vd2 gdTCR': '433.9', 'Memory CD4 T-cell Th1': '167.1', 'Memory CD4 T-cell TFH': '206.6', 'Terminal effector memory CD4 T-cell': '415.3', 'Central memory CD8 T-cell': '404.6', 'Effector memory CD8 T-cell': '529.4', 'Terminal effector memory CD8 T-cell': '440.6', 'Non-switched memory B-cell': '390.7', 'Plasmablast': '600.2', 'Switched memory B-cell': '439.5', 'Exhausted memory B-cell': '398.3', 'Progenitor cell': '300.9', 'Memory T-reg': '224.4', 'Naive CD4 T-cell activated': '763.6', 'Naive CD8 T-cell activated': '769.9', 'Naive T-reg': '183.4'}
2HGL, 2HGM, 2HGN, 2KFY, 2KG0, 2KG1, 3TFY
{'Adipose Tissue': 125.73534883720929, 'Adrenal Gland': 79.45829457364341, 'Bladder': 131.32, 'Blood': 111.1290796555436, 'Blood Vessel': 98.61894382022471, 'Brain': 32.773102195306585, 'Breast': 124.46043572984748, 'Cervix Uteri': 123.24368421052633, 'Colon': 112.56305519897305, 'Esophagus': 113.08056747404844, 'Fallopian Tube': 149.3, 'Heart': 33.22322299651568, 'Kidney': 63.02011235955056, 'Liver': 71.19234513274336, 'Lung': 140.6005882352941, 'Muscle': 52.9818804483188, 'Nerve': 118.36004846526656, 'Ovary': 136.19077777777778, 'Pancreas': 42.760021341463414, 'Pituitary': 72.04985865724382, 'Prostate': 101.71265306122449, 'Salivary Gland': 97.37327160493828, 'Skin': 155.26353233830844, 'Small Intestine': 125.39508021390375, 'Spleen': 131.248755186722, 'Stomach': 93.18643454038995, 'Testis': 127.70914127423822, 'Thyroid': 104.50805513016844, 'Uterus': 119.3562676056338, 'Vagina': 117.92506410256412}
[86.6, 87.14, 88.61, 89.01, 89.67, 88.44, 87.46, 83.77, 82.45, 81.33, 82.97, 84.74, 86.57, 89.57, 90.1, 90.69, 89.67, 90.34, 87.71, 89.23, 89.95, 93.02, 92.3, 92.09, 92.37, 91.58, 92.58, 92.83, 92.29, 90.48, 91.02, 91.12, 88.85, 86.99, 87.58, 87.73, 90.05, 90.01, 88.64, 86.82, 89.42, 87.19, 90.11, 87.28, 86.12, 78.81, 73.0, 79.54, 85.09, 87.69, 88.54, 89.59, 88.97, 88.84, 90.12, 86.33, 83.17, 85.28, 79.1, 80.69, 81.01, 82.27, 82.43, 81.52, 86.22, 87.46, 90.66, 87.7, 89.96, 86.4, 86.05, 77.55, 70.82, 62.18, 61.34, 52.16, 38.83, 44.34, 30.73, 31.43, 26.08, 27.82, 32.43, 27.17, 32.44, 31.46, 28.93, 37.69, 33.58, 33.3, 32.79, 32.77, 31.16, 30.63, 29.11, 31.16, 33.22, 35.12, 33.91, 30.34, 35.05, 29.65, 35.87, 27.96, 32.25, 26.15, 30.35, 26.66, 31.89, 33.33, 30.55, 30.74, 35.12, 32.39, 29.71, 33.62, 34.73, 26.72, 31.71, 28.39, 33.89, 31.11, 34.89, 29.86, 26.98, 29.31, 28.71, 29.87, 26.72, 29.64, 28.01, 35.03, 32.42, 26.03, 26.21, 25.78, 27.97, 25.32, 28.69, 42.33, 50.14, 59.81, 73.34, 80.84, 81.26, 91.68, 94.51, 94.99, 94.31, 93.33, 90.47, 88.44, 92.04, 91.72, 91.25, 91.84, 94.01, 93.92, 93.04, 90.7, 89.16, 91.17, 90.11, 90.68, 90.26, 89.74, 92.18, 92.02, 90.56, 89.44, 86.56, 84.44, 85.5, 85.08, 87.47, 89.13, 87.45, 87.73, 87.57, 91.74, 90.15, 90.56, 90.97, 92.39, 92.62, 91.9, 92.26, 92.16, 91.66, 90.75, 92.44, 91.33, 92.54, 90.83, 90.48, 89.4, 89.6, 84.64, 87.28, 87.95, 84.16, 91.86, 89.62, 92.55, 93.61, 92.4, 93.23, 93.33, 92.76, 93.56, 91.0, 92.54, 89.74, 89.48, 89.91, 88.33, 86.79, 86.93, 80.65, 84.69, 87.55, 91.61, 92.58, 92.61, 93.6, 93.85, 92.89, 94.12, 94.58, 91.59, 90.69, 90.31, 84.69, 83.48, 87.8, 89.95, 93.44, 94.32, 93.73, 90.77, 90.73, 91.35, 92.61, 92.07, 91.36, 91.1, 93.93, 94.82, 95.89, 95.03, 95.16, 92.39, 92.77, 90.89, 89.77, 91.95, 94.22, 94.76, 95.62, 95.26, 94.61, 92.28, 93.2, 95.01, 93.32, 91.52, 93.54, 93.31, 91.4, 89.65, 91.18, 89.05, 88.05, 87.94, 88.85, 89.82, 91.79, 92.63, 92.54, 92.06, 89.88, 89.67, 89.07, 91.55, 93.84, 94.98, 95.12, 95.1, 94.48, 92.52, 90.87, 90.19, 92.01, 91.36, 90.6, 93.83, 94.81, 95.01, 93.21, 91.96, 93.44, 92.68, 94.49, 95.0, 93.51, 92.8, 91.23, 90.04, 89.36, 88.14, 90.5, 92.38, 90.6, 90.2, 92.1, 91.02, 89.08, 89.88, 86.7, 86.54, 88.71, 88.57, 86.26, 88.98, 88.9, 88.32, 88.97, 87.29, 88.96, 89.96, 89.35, 88.03, 85.91, 82.77, 75.14, 75.43, 80.18, 79.23, 84.69, 85.78, 87.42, 87.75, 87.16, 87.6, 84.92, 85.06, 88.44, 89.95, 91.76, 90.7, 90.29, 87.05, 79.67, 62.52, 56.91, 60.2, 56.44, 65.23, 71.08, 83.76, 85.05, 87.42, 91.12, 91.7, 91.75, 88.29, 87.13, 85.75, 85.93, 86.7, 89.58, 90.19, 90.4, 86.67, 89.15, 87.4, 86.34, 78.61, 70.66, 66.43, 65.14, 58.91, 50.78, 46.67, 36.54, 35.27, 32.59, 40.61, 47.31, 50.77, 62.41, 70.48, 78.66, 85.25, 86.67, 88.92, 89.3, 88.85, 87.79, 87.66, 89.94, 91.09, 85.42, 72.16, 57.86, 51.98, 52.44, 47.51, 45.51, 48.58, 51.24, 52.02, 56.52, 70.54, 78.5, 85.42, 88.76, 89.24, 92.22, 89.92, 91.66, 88.73, 88.39, 87.92, 87.02, 85.8, 83.44, 74.02, 80.21, 84.48, 87.59, 88.21, 89.27, 90.78, 91.24, 91.53, 90.4, 90.16, 90.37, 90.19, 90.87, 89.71, 92.15, 92.34, 93.0, 92.02, 89.02, 86.0, 88.39, 88.77, 90.21, 92.62, 91.03, 89.53, 85.52, 87.96, 88.06, 86.94, 83.84, 86.53, 86.56, 87.5, 88.23, 82.06, 76.01]
[0.3, 0.19, 0.02, 0.02, 0.0, 0.08, 0.07, 0.12, 0.1, 0.29, 0.13, 0.0, 0.08, 0.4, 0.08, 0.86, 0.06, 0.64, 0.51, 0.76, 0.17, 0.23, 0.0, 0.42, 0.46, 0.04, 0.05, 0.38, 0.51, 0.01, 0.11, 0.81, 0.61, 0.34, 0.79, 0.2, 0.5, 0.2, 0.8, 0.29, 0.02, 0.07, 0.0, 0.01, 0.15, 0.37, 0.23, 0.67, 0.42, 0.05, 0.57, 0.41, 0.67, 0.4, 0.24, 0.03, 0.72, 0.65, 0.11, 0.71, 0.08, 0.66, 0.59, 0.49, 0.11, 0.22, 0.01, 0.08, 0.0, 0.01, 0.37, 0.2, 0.55, 0.58, 0.7, 0.7, 0.84, 0.57, 0.73, 0.81, 0.94, 0.84, 0.96, 0.99, 0.81, 0.96, 0.91, 0.93, 0.96, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.85, 1.0, 0.81, 1.0, 0.98, 1.0, 1.0, 0.92, 0.96, 0.94, 0.94, 1.0, 1.0, 1.0, 0.99, 1.0, 0.99, 1.0, 0.99, 1.0, 0.97, 0.92, 0.92, 0.75, 0.78, 0.77, 0.81, 0.93, 0.83, 0.96, 0.85, 0.98, 0.87, 0.9, 0.95, 0.92, 0.95, 0.89, 0.92, 0.71, 0.94, 0.91, 0.74, 0.82, 0.75, 0.29, 0.14, 0.04, 0.0, 0.11, 0.0, 0.06, 0.01, 0.58, 0.68, 0.79, 0.26, 0.47, 0.55, 0.25, 0.12, 0.33, 0.01, 0.29, 0.0, 0.29, 0.17, 0.19, 0.0, 0.34, 0.62, 0.34, 0.7, 0.44, 0.77, 0.3, 0.1, 0.56, 0.2, 0.72, 0.7, 0.29, 0.0, 0.35, 0.39, 0.12, 0.55, 0.1, 0.09, 0.46, 0.53, 0.91, 0.61, 0.66, 0.06, 0.52, 0.15, 0.67, 0.09, 0.58, 0.2, 0.92, 0.94, 0.2, 0.75, 0.03, 0.58, 0.27, 0.07, 0.36, 0.13, 0.14, 0.05, 0.08, 0.01, 0.27, 0.61, 0.25, 0.98, 0.26, 0.48, 0.67, 0.89, 0.48, 0.65, 0.17, 0.33, 0.13, 0.0, 0.25, 0.06, 0.0, 0.07, 0.24, 0.07, 0.57, 0.29, 0.62, 0.08, 0.21, 0.03, 0.02, 0.38, 0.34, 0.49, 0.4, 0.52, 0.22, 0.35, 0.18, 0.03, 0.0, 0.11, 0.01, 0.36, 0.01, 0.91, 0.29, 0.35, 0.05, 0.0, 0.0, 0.04, 0.15, 0.22, 0.12, 0.0, 0.06, 0.1, 0.06, 0.0, 0.0, 0.06, 0.12, 0.05, 0.0, 0.23, 0.21, 0.37, 0.08, 0.41, 0.59, 0.35, 0.85, 0.96, 0.29, 0.3, 0.17, 0.0, 0.01, 0.25, 0.01, 0.06, 0.39, 0.69, 0.21, 0.89, 0.89, 0.02, 0.23, 0.02, 0.66, 0.33, 0.25, 0.35, 0.0, 0.0, 0.22, 0.15, 0.08, 0.26, 0.49, 0.63, 0.07, 0.1, 0.55, 0.22, 0.1, 0.6, 0.58, 0.02, 0.34, 0.5, 0.15, 0.19, 0.41, 0.17, 0.36, 0.74, 0.62, 0.43, 0.18, 0.07, 0.12, 0.04, 0.09, 0.48, 0.45, 0.84, 0.29, 0.3, 0.3, 0.5, 0.1, 0.62, 0.25, 0.79, 0.77, 0.95, 0.45, 0.33, 0.46, 0.03, 0.36, 0.02, 0.78, 0.39, 0.94, 0.86, 0.76, 0.8, 0.31, 0.26, 0.61, 0.25, 0.31, 0.0, 0.0, 0.26, 0.69, 0.1, 0.33, 0.4, 0.53, 0.34, 0.3, 0.81, 0.61, 0.91, 0.29, 0.58, 0.75, 0.28, 0.48, 0.19, 0.6, 0.79, 0.73, 0.43, 0.82, 0.53, 0.59, 0.64, 0.21, 0.83, 0.24, 0.61, 0.77, 0.74, 0.06, 0.14, 0.6, 0.56, 0.0, 0.4, 0.08, 0.56, 0.62, 0.3, 0.5, 0.86, 0.92, 0.48, 0.7, 0.74, 0.73, 0.51, 0.52, 0.31, 0.61, 0.0, 0.37, 0.59, 0.36, 0.65, 0.32, 0.69, 0.07, 0.6, 0.25, 0.76, 0.64, 0.19, 0.13, 0.03, 0.35, 0.08, 0.61, 0.05, 0.67, 0.47, 0.64, 0.99, 0.12, 0.63, 0.08, 0.36, 0.02, 0.0, 0.08, 0.5, 0.34, 0.38, 0.36, 0.68, 0.18, 0.4, 0.75, 0.63, 0.04, 0.25, 0.01, 0.14, 0.06, 0.05, 0.01, 0.45, 0.31]
[37.16, 33.69, 38.2, 39.05, 45.57, 38.49, 36.92, 44.82, 55.0, 66.67, 82.77, 86.06, 89.57, 89.98, 90.07, 88.31, 84.67, 85.14, 83.03, 81.93, 83.57, 82.94, 84.78, 86.65, 85.8, 86.3, 85.39, 85.42, 84.5, 83.38, 82.27, 81.53, 80.38, 79.62, 80.41, 78.98, 71.92, 70.0, 74.79, 73.2, 75.29, 79.83, 85.1, 84.38, 86.25, 84.61, 79.57, 72.56, 66.78, 68.87, 71.65, 76.28, 80.67, 79.42, 82.99, 88.16, 89.07, 89.37, 88.82, 87.38, 86.7, 82.94, 83.84, 85.1, 85.46, 85.66, 85.62, 87.02, 85.6, 85.73, 87.51, 87.96, 81.38, 84.77, 80.94, 81.81, 77.47, 74.07, 72.82, 78.51, 85.03, 85.8, 88.58, 88.06, 91.09, 88.89, 89.42, 84.34, 82.76, 78.96, 80.96, 81.05, 81.12, 77.77, 77.69, 76.66, 74.43, 68.57, 64.65, 59.84, 51.32, 49.4, 40.66, 43.41, 45.1, 46.75, 46.91, 47.98, 51.25, 60.09, 69.83, 78.95, 85.37, 85.62, 87.12, 85.3, 82.29, 83.21, 80.11, 75.99, 77.26, 77.43, 81.34, 82.42, 83.63, 84.82, 83.81, 84.48, 83.9, 82.69, 82.01, 76.27, 73.4, 79.48, 75.18, 79.12, 76.67, 59.98, 65.12, 70.57, 80.5, 79.51, 81.15, 73.85, 76.05, 68.95, 65.15, 66.97, 68.52, 68.98, 76.18, 74.87, 78.48, 84.4, 85.16, 86.14, 86.05, 84.44, 83.93, 79.7, 77.81, 79.87, 82.26, 82.45, 82.6, 83.38, 83.42, 83.24, 83.82, 82.79, 79.47, 83.01, 81.12, 82.21, 80.66, 80.53, 78.8, 79.9, 84.78, 85.96, 86.93, 85.95, 87.56, 84.23, 82.53, 69.99, 70.02, 63.65, 58.23, 62.54, 60.27, 57.85, 56.47, 57.16, 52.59, 45.61, 41.32, 37.93, 38.18, 35.44, 34.62, 35.08, 38.74, 44.7, 36.38, 42.26, 43.18, 45.31, 57.0, 57.23, 48.48, 52.82, 43.22, 35.0, 39.26, 37.45, 36.5, 34.55, 30.8, 30.88, 33.52, 30.51, 35.96, 36.4, 37.65, 36.42, 36.11, 37.03, 33.55, 38.57, 35.2, 40.85, 42.42, 39.61, 42.38, 42.42, 41.05, 43.74, 41.47, 40.99, 41.63, 38.04, 40.71, 37.35, 36.16, 34.58, 33.78, 34.57, 35.31, 29.98, 35.33, 38.81, 35.55, 41.13, 35.74, 38.06, 36.67, 44.91, 45.9, 43.06, 41.59, 52.12, 43.02, 45.07, 46.53, 41.12, 42.92, 36.73, 34.38, 36.12, 32.65, 31.68, 33.1, 30.07, 30.22, 32.06, 32.01, 29.22, 28.44, 35.27, 32.34, 33.89, 46.88, 46.22, 52.09, 55.52, 65.77, 73.13, 80.91, 84.38, 88.03, 89.36, 89.07, 87.51, 84.14, 83.92, 81.46, 81.38, 81.2, 79.78, 83.38, 85.74, 84.75, 86.14, 85.52, 86.24, 83.59, 84.04, 82.77, 78.7, 77.87, 82.1, 76.97, 82.01, 82.51, 82.34, 85.44, 85.26, 86.01, 81.62, 82.22, 79.63, 75.86, 77.63, 76.62, 75.51, 80.69, 81.46, 82.58, 88.18, 87.94, 88.56, 87.6, 87.41, 86.6, 83.86, 83.6, 86.3, 86.16, 85.7, 87.28, 86.54, 87.04, 86.19, 85.48, 84.82, 79.75, 85.23, 81.45, 80.61, 79.63, 74.79, 74.8, 79.86, 83.82, 84.86, 85.46, 87.93, 88.93, 87.51, 84.8, 80.84, 70.1, 66.03, 56.18, 46.51, 37.61, 38.63, 38.01, 32.97, 31.06, 29.74, 30.94, 31.2, 30.67, 35.54, 31.81, 32.54, 32.85, 32.52, 36.0, 39.94, 40.16, 36.68, 36.48, 34.18, 37.33, 34.12, 30.75, 38.65, 33.19, 37.94, 32.39, 35.74, 36.55, 32.29, 37.99, 37.5, 37.37, 36.13, 38.63, 39.77, 40.93, 39.94, 39.78, 41.64, 44.87, 48.55, 42.57, 46.2, 46.72, 45.86, 51.03, 44.97, 46.01]
[0.99, 0.98, 0.98, 0.8, 0.94, 0.94, 0.77, 0.76, 0.72, 0.3, 0.26, 0.01, 0.0, 0.06, 0.0, 0.2, 0.22, 0.02, 0.11, 0.58, 0.8, 0.06, 0.41, 0.28, 0.69, 0.35, 0.0, 0.33, 0.66, 0.07, 0.01, 0.66, 0.58, 0.11, 0.57, 0.15, 0.55, 0.75, 0.26, 0.53, 0.57, 0.03, 0.08, 0.27, 0.14, 0.07, 0.39, 0.32, 0.97, 0.87, 0.46, 0.57, 0.2, 0.34, 0.08, 0.14, 0.0, 0.0, 0.0, 0.15, 0.04, 0.5, 0.37, 0.48, 0.55, 0.05, 0.05, 0.38, 0.37, 0.0, 0.4, 0.76, 0.14, 0.43, 0.77, 0.46, 0.71, 0.16, 0.83, 0.93, 0.39, 0.63, 0.0, 0.27, 0.06, 0.47, 0.56, 0.06, 0.59, 0.48, 0.71, 0.29, 0.04, 0.39, 0.29, 0.08, 0.3, 0.73, 0.56, 0.25, 0.39, 0.56, 0.83, 0.45, 0.56, 0.86, 0.35, 0.5, 0.43, 0.51, 0.05, 0.06, 0.01, 0.2, 0.0, 0.44, 0.18, 0.0, 0.12, 0.64, 0.7, 0.03, 0.48, 0.64, 0.74, 0.35, 0.0, 0.51, 0.71, 0.1, 0.01, 0.67, 0.98, 0.2, 0.67, 0.21, 0.33, 0.94, 0.92, 0.07, 0.25, 0.29, 0.28, 0.08, 0.58, 0.44, 0.97, 0.76, 0.67, 0.62, 0.21, 0.35, 0.05, 0.1, 0.0, 0.01, 0.0, 0.27, 0.03, 0.59, 0.4, 0.4, 0.59, 0.14, 0.1, 0.53, 0.47, 0.0, 0.37, 0.73, 0.26, 0.43, 0.69, 0.4, 0.79, 0.07, 0.83, 0.91, 0.34, 0.62, 0.0, 0.28, 0.05, 0.36, 0.8, 0.11, 0.19, 0.28, 0.54, 0.41, 0.04, 0.6, 0.71, 0.54, 0.5, 0.71, 0.87, 0.77, 0.86, 0.82, 0.89, 0.66, 0.84, 0.56, 0.86, 0.92, 0.68, 0.34, 0.96, 0.95, 0.7, 0.93, 0.92, 0.82, 0.93, 0.82, 0.96, 0.94, 1.0, 0.96, 1.0, 0.97, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.99, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.73, 0.69, 0.96, 0.69, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.89, 0.83, 0.78, 0.67, 0.52, 0.47, 0.9, 0.6, 0.22, 0.68, 0.32, 0.32, 0.85, 0.76, 0.61, 0.3, 0.82, 0.79, 0.75, 0.88, 0.71, 0.96, 0.92, 0.98, 0.68, 0.99, 0.32, 0.69, 0.47, 0.44, 0.14, 0.62, 0.26, 0.7, 0.3, 0.45, 0.14, 0.11, 0.0, 0.04, 0.0, 0.27, 0.19, 0.02, 0.02, 0.65, 0.84, 0.12, 0.48, 0.43, 0.45, 0.26, 0.0, 0.38, 0.35, 0.12, 0.0, 0.29, 0.81, 0.18, 0.68, 0.09, 0.49, 0.44, 0.08, 0.41, 0.15, 0.09, 0.58, 0.25, 0.99, 0.65, 0.7, 0.73, 0.28, 0.36, 0.02, 0.24, 0.0, 0.01, 0.0, 0.01, 0.0, 0.48, 0.43, 0.25, 0.81, 0.22, 0.0, 0.42, 0.36, 0.0, 0.28, 0.78, 0.23, 0.41, 0.68, 0.33, 0.69, 0.08, 0.63, 0.92, 0.29, 0.62, 0.0, 0.3, 0.06, 0.45, 0.38, 0.3, 0.21, 0.64, 0.74, 0.69, 0.98, 0.94, 0.98, 0.91, 0.99, 0.99, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.97, 0.99, 0.97, 0.99, 1.0, 0.86, 1.0, 0.95, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.86, 1.0, 0.97, 1.0]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
64.642602
0.541663
1,774
O60260
P52789
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
HK2
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQR
Homo sapiens
Mitochondrion outer membrane, Cytoplasm, cytosol
Tissue enhanced (retina)
{'Ciliated cells': '9.5', 'Basal respiratory cells': '24.2', 'Club cells': '25.3', 'Ionocytes': '26.5', 'Mucus glandular cells': '8.6', 'Serous glandular cells': '13.3', 'Gastric mucus-secreting cells': '15.3', 'Proximal enterocytes': '4.4', 'Paneth cells': '69.4', 'Distal enterocytes': '150.4', 'Intestinal goblet cells': '51.1', 'Exocrine glandular cells': '-0.342', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '4.2', 'Breast glandular cells': '-0.273', 'Breast myoepithelial cells': '-0.308', 'Glandular and luminal cells': '12.9', 'Secretory cells': '18.4', 'Basal keratinocytes': '41.0', 'Suprabasal keratinocytes': '45.3', 'Basal squamous epithelial cells': '9.8', 'Squamous epithelial cells': '9.7', 'Alveolar cells type 1': '0.052', 'Alveolar cells type 2': '0.418', 'Salivary duct cells': '4.9', 'Ductal cells': '0.450', 'Hepatocytes': '0.247', 'Cholangiocytes': '3.8', 'Proximal tubular cells': '0.099', 'Distal tubular cells': '0.0', 'Collecting duct cells': '5.8', 'Mesothelial cells': '-0.118', 'Sertoli cells': '0.614', 'Granulosa cells': '19.5', 'Enteroendocrine cells': '46.6', 'Pancreatic endocrine cells': '1.7', 'Leydig cells': '0.379', 'Excitatory neurons': '0.2', 'Inhibitory neurons': '0.1', 'Cone photoreceptor cells': '125.7', 'Rod photoreceptor cells': '35.8', 'Bipolar cells': '18.1', 'Horizontal cells': '8.8', 'Astrocytes': '4.6', 'Oligodendrocyte precursor cells': '0.5', 'Oligodendrocytes': '0.7', 'Microglial cells': '24.2', 'Muller glia cells': '6.3', 'Schwann cells': '0.085', 'Spermatogonia': '0.506', 'Spermatocytes': '0.381', 'Early spermatids': '-0.177', 'Late spermatids': '-0.277', 'Oocytes': '2.2', 'Cytotrophoblasts': '2.2', 'Syncytiotrophoblasts': '8.4', 'Extravillous trophoblasts': '39.2', 'Endothelial cells': '2.4', 'Lymphatic endothelial cells': '0.7', 'Cardiomyocytes': '0.538', 'Skeletal myocytes': '-0.115', 'Smooth muscle cells': '2.1', 'Adipocytes': '1.5', 'Melanocytes': '0.031', 'Fibroblasts': '5.4', 'Peritubular cells': '0.181', 'Endometrial stromal cells': '3.7', 'Ovarian stromal cells': '4.7', 'Undifferentiated cells': '14.1', 'T-cells': '3.6', 'B-cells': '5.6', 'Plasma cells': '6.0', 'Nk-cells': '0.8', 'Granulocytes': '48.1', 'Monocytes': '19.3', 'Macrophages': '30.6', 'Hofbauer cells': '26.1', 'Kupffer cells': '20.3', 'Dendritic cells': '1.6', 'Langerhans cells': '-0.025', 'Erythroid cells': '0.063', 'Adipocytes (Subcutaneous)': '0.424', 'Adipocytes (Visceral)': '0.573', 'Breast glandular cells (progenitors)': '-0.435', 'Adipocytes (Breast)': '0.527', 'Colon enterocytes': '0.463', 'Colon enteroendocrine cells': '-0.106', 'Enteric glia cells': '-0.259', 'Mitotic cells (Colon)': '0.440', 'Mitotic cells (Heart)': '0.443', 'Podocytes': '-0.044', 'Ascending Loop of Henle cells': '0.166', 'Intercalated cells': '-0.154', 'Cholangiocyte': '0.400', 'NK-cells (Liver)': '-0.213', 'Respiratory ciliated cells': '-0.150', 'Mitotic cells (Lung)': '0.022', 'NK-cells (Lung)': '-0.172', 'B-cells (Lung)': '-0.113', 'Alpha cells': '0.081', 'Beta cells': '0.014', 'Prostate glandular cells': '-0.056', 'Prostate basal glandular cells': '0.274', 'Urothelial cells': '0.482', 'Keratinocyte (other)': '-0.039', 'Keratinocyte (granular)': '-0.279', 'Hair cortex cells': '0.281', 'Inner root sheath cells': '0.242', 'Outer root sheath cells': '0.463', 'Sebaceous gland cells': '0.055', 'Eccrine sweat gland cells': '0.063', 'Adipocytes (Skin)': '-0.019', 'Mitotic cells (Skin)': '0.200', 'Parietal cells': '0.609', 'Chief cells': '0.444', 'Gastric mucous cells': '0.669', 'Gastric enteroendocrine cells': '0.433', 'Mitotic cells (Stomach)': '0.373', 'Parafollicular cells': '0.092', 'Thyroid glandular cells': '0.347', 'Mitotic cells (Thyroid)': '0.095', 'Adrenal cortex cells': '0.290', 'Adrenal medulla cells': '0.056', 'Mitotic cells (Adrenal gland)': '0.073', 'Minor salivary glandular cells': '-0.217', 'Minor salivary gland ductal cells': '-0.318', 'Minor salivary gland basal cells': '0.449', 'Mitotic cells (Minor salivary gland)': '0.325', 'Adipocytes (Minor salivary gland)': '0.094', 'Somatotropes': '-0.276', 'Lactotropes': '-0.279', 'Gonadotropes': '-0.229', 'Corticotropes': '0.043', 'Thyrotropes': '0.096', 'Undifferentiated cells (Pituitary gland)': '0.188', 'Mitotic cells (Spleen)': '0.003', 'Platelets': '0.060', 'Erythrocytes': '-0.094', 'Hematopoietic stem cells': '0.120', 'B-cells (Spleen)': '0.155', 'NK-cells (Spleen)': '0.036', 'Amygdala excitatory': '0.6', 'Cerebellar inhibitory': '0.4', 'Cge interneuron': '0.3', 'Deep-layer corticothalamic and 6b': '0.5', 'Deep-layer intratelencephalic': '0.5', 'Deep-layer near-projecting': '0.5', 'Eccentric medium spiny neuron': '0.3', 'Hippocampal ca1-3': '0.7', 'Hippocampal ca4': '0.4', 'Hippocampal dentate gyrus': '0.5', 'Lamp5-lhx6 and chandelier': '0.2', 'Lower rhombic lip': '0.1', 'Mammillary body': '0.5', 'Medium spiny neuron': '0.4', 'Mge interneuron': '0.2', 'Midbrain-derived inhibitory': '0.5', 'Miscellaneous': '0.3', 'Splatter': '0.5', 'Thalamic excitatory': '0.2', 'Upper rhombic lip': '0.4', 'Upper-layer intratelencephalic': '0.7', 'Astrocyte': '38.2', 'Bergmann glia': '5.9', 'Central nervous system macrophage': '130.1', 'Choroid plexus epithelial cell': '1.1', 'Committed oligodendrocyte precursor': '3.2', 'Ependymal cell': '3.1', 'Oligodendrocyte': '1.0', 'Oligodendrocyte precursor cell': '3.2', 'Endothelial cell': '1.8', 'Pericyte': '1.0', 'Vascular associated smooth muscle cell': '9.8', 'Fibroblast': '14.1', 'Leukocyte': '9.5', 'Basophil': '67.3', 'Eosinophil': '51.8', 'Neutrophil': '120.3', 'Classical monocyte': '147.9', 'Non-classical monocyte': '31.7', 'Intermediate monocyte': '46.9', 'T-reg': '5.9', 'GdT-cell': '0.2', 'MAIT T-cell': '6.3', 'Memory CD4 T-cell': '0.8', 'Naive CD4 T-cell': '13.3', 'Memory CD8 T-cell': '0.1', 'Naive CD8 T-cell': '13.4', 'Memory B-cell': '1.2', 'Naive B-cell': '19.4', 'Plasmacytoid DC': '1.2', 'Myeloid DC': '48.1', 'NK-cell': '0.6', 'Total PBMC': '31.7', 'Vd2 gdTCR': '1.4', 'Memory CD4 T-cell Th1\\/Th17': '10.5', 'Memory CD4 T-cell Th17': '8.9', 'Memory CD4 T-cell Th2': '9.5', 'Non-Vd2 gdTCR': '1.4', 'Memory CD4 T-cell Th1': '6.5', 'Memory CD4 T-cell TFH': '7.1', 'Terminal effector memory CD4 T-cell': '1.1', 'Central memory CD8 T-cell': '3.0', 'Effector memory CD8 T-cell': '1.5', 'Terminal effector memory CD8 T-cell': '0.3', 'Non-switched memory B-cell': '17.5', 'Plasmablast': '13.6', 'Switched memory B-cell': '9.9', 'Exhausted memory B-cell': '7.1', 'Progenitor cell': '14.9', 'Memory T-reg': '10.1', 'Naive CD4 T-cell activated': '160.2', 'Naive CD8 T-cell activated': '158.5', 'Naive T-reg': '14.7'}
2NZT, 5HEX, 5HFU, 5HG1
{'Adipose Tissue': 37.641459302325586, 'Adrenal Gland': 4.102834496124031, 'Bladder': 15.61995238095238, 'Blood': 63.30483100107643, 'Blood Vessel': 20.708283146067416, 'Brain': 2.6710101514004543, 'Breast': 28.1079825708061, 'Cervix Uteri': 8.380894736842107, 'Colon': 25.06199807445443, 'Esophagus': 13.498142975778546, 'Fallopian Tube': 9.465, 'Heart': 7.000216469221836, 'Kidney': 2.934225842696629, 'Liver': 1.0597592920353982, 'Lung': 24.15070242214533, 'Muscle': 36.25943848069738, 'Nerve': 7.411095315024232, 'Ovary': 33.1341, 'Pancreas': 1.9343865853658535, 'Pituitary': 3.9704978798586574, 'Prostate': 10.716212653061223, 'Salivary Gland': 22.922314814814815, 'Skin': 29.64419402985075, 'Small Intestine': 19.507527272727273, 'Spleen': 11.923410788381744, 'Stomach': 14.8102217270195, 'Testis': 69.0657617728532, 'Thyroid': 13.336324655436448, 'Uterus': 3.0029964788732393, 'Vagina': 29.539971794871796}
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0.62, 0.07, 0.49, 0.32, 0.01, 0.2, 0.62, 0.18, 0.0, 0.33, 0.53, 0.07, 0.03, 0.75, 0.58, 0.04, 0.0, 0.73, 0.56, 0.1, 0.57, 0.2, 0.43, 0.18, 0.33, 0.56, 0.05, 0.91, 0.15, 0.01, 0.1, 0.0, 0.11, 0.0, 0.0, 0.0, 0.0, 0.02, 0.0, 0.02, 0.04, 0.17, 0.22, 0.23, 0.54, 0.64, 0.57, 0.55, 0.78, 0.77, 0.83]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
91.847219
0.258757
620
O60260
P53667
17512523, E3Net
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
LIMK1
MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
Homo sapiens
Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, Cell projection, lamellipodium
Tissue enriched (brain)
{'Ciliated cells': '2.6', 'Basal respiratory cells': '5.7', 'Club cells': '4.7', 'Ionocytes': '2.9', 'Mucus glandular cells': '8.6', 'Serous glandular cells': '5.4', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '0.2', 'Paneth cells': '4.0', 'Distal enterocytes': '3.2', 'Intestinal goblet cells': '2.9', 'Exocrine glandular cells': '-0.624', 'Basal prostatic cells': '5.2', 'Prostatic glandular cells': '2.5', 'Breast glandular cells': '0.493', 'Breast myoepithelial cells': '0.312', 'Glandular and luminal cells': '5.1', 'Secretory cells': '3.8', 'Basal keratinocytes': '4.2', 'Suprabasal keratinocytes': '4.1', 'Basal squamous epithelial cells': '1.8', 'Squamous epithelial cells': '1.9', 'Alveolar cells type 1': '-0.300', 'Alveolar cells type 2': '0.110', 'Salivary duct cells': '8.1', 'Ductal cells': '0.672', 'Hepatocytes': '0.351', 'Cholangiocytes': '7.6', 'Proximal tubular cells': '0.091', 'Distal tubular cells': '0.0', 'Collecting duct cells': '3.9', 'Mesothelial cells': '0.344', 'Sertoli cells': '0.375', 'Granulosa cells': '5.2', 'Enteroendocrine cells': '3.1', 'Pancreatic endocrine cells': '10.2', 'Leydig cells': '0.390', 'Excitatory neurons': '14.9', 'Inhibitory neurons': '20.0', 'Cone photoreceptor cells': '3.4', 'Rod photoreceptor cells': '1.8', 'Bipolar cells': '4.1', 'Horizontal cells': '23.3', 'Astrocytes': '7.1', 'Oligodendrocyte precursor cells': '6.1', 'Oligodendrocytes': '2.2', 'Microglial cells': '6.3', 'Muller glia cells': '3.3', 'Schwann cells': '0.186', 'Spermatogonia': '0.707', 'Spermatocytes': '0.327', 'Early spermatids': '-0.327', 'Late spermatids': '-0.441', 'Oocytes': '8.8', 'Cytotrophoblasts': '2.5', 'Syncytiotrophoblasts': '3.5', 'Extravillous trophoblasts': '6.8', 'Endothelial cells': '3.5', 'Lymphatic endothelial cells': '3.8', 'Cardiomyocytes': '0.481', 'Skeletal myocytes': '-0.291', 'Smooth muscle cells': '3.9', 'Adipocytes': '2.7', 'Melanocytes': '-0.135', 'Fibroblasts': '6.5', 'Peritubular cells': '0.332', 'Endometrial stromal cells': '9.2', 'Ovarian stromal cells': '6.3', 'Undifferentiated cells': '3.5', 'T-cells': '10.2', 'B-cells': '9.0', 'Plasma cells': '10.6', 'Nk-cells': '19.0', 'Granulocytes': '10.6', 'Monocytes': '5.6', 'Macrophages': '16.7', 'Hofbauer cells': '25.6', 'Kupffer cells': '13.2', 'Dendritic cells': '2.0', 'Langerhans cells': '0.061', 'Erythroid cells': '-0.062', 'Adipocytes (Subcutaneous)': '-0.280', 'Adipocytes (Visceral)': '-0.284', 'Breast glandular cells (progenitors)': '0.485', 'Adipocytes (Breast)': '-0.379', 'Colon enterocytes': '-0.003', 'Colon enteroendocrine cells': '0.296', 'Enteric glia cells': '0.436', 'Mitotic cells (Colon)': '0.177', 'Mitotic cells (Heart)': '0.544', 'Podocytes': '-0.219', 'Ascending Loop of Henle cells': '0.336', 'Intercalated cells': '-0.164', 'Cholangiocyte': '0.379', 'NK-cells (Liver)': '-0.247', 'Respiratory ciliated cells': '-0.104', 'Mitotic cells (Lung)': '0.435', 'NK-cells (Lung)': '-0.114', 'B-cells (Lung)': '-0.006', 'Alpha cells': '0.408', 'Beta cells': '0.203', 'Prostate glandular cells': '-0.374', 'Prostate basal glandular cells': '0.022', 'Urothelial cells': '0.284', 'Keratinocyte (other)': '-0.394', 'Keratinocyte (granular)': '-0.151', 'Hair cortex cells': '0.347', 'Inner root sheath cells': '0.250', 'Outer root sheath cells': '0.413', 'Sebaceous gland cells': '0.203', 'Eccrine sweat gland cells': '0.381', 'Adipocytes (Skin)': '0.345', 'Mitotic cells (Skin)': '0.013', 'Parietal cells': '-0.417', 'Chief cells': '-0.282', 'Gastric mucous cells': '0.011', 'Gastric enteroendocrine cells': '-0.058', 'Mitotic cells (Stomach)': '0.313', 'Parafollicular cells': '0.115', 'Thyroid glandular cells': '0.300', 'Mitotic cells (Thyroid)': '0.132', 'Adrenal cortex cells': '0.277', 'Adrenal medulla cells': '0.088', 'Mitotic cells (Adrenal gland)': '0.337', 'Minor salivary glandular cells': '0.736', 'Minor salivary gland ductal cells': '0.106', 'Minor salivary gland basal cells': '0.075', 'Mitotic cells (Minor salivary gland)': '0.255', 'Adipocytes (Minor salivary gland)': '0.096', 'Somatotropes': '-0.105', 'Lactotropes': '-0.155', 'Gonadotropes': '0.236', 'Corticotropes': '-0.197', 'Thyrotropes': '-0.011', 'Undifferentiated cells (Pituitary gland)': '0.252', 'Mitotic cells (Spleen)': '-0.035', 'Platelets': '0.011', 'Erythrocytes': '-0.126', 'Hematopoietic stem cells': '-0.116', 'B-cells (Spleen)': '0.307', 'NK-cells (Spleen)': '0.229', 'Amygdala excitatory': '26.0', 'Cerebellar inhibitory': '35.6', 'Cge interneuron': '22.3', 'Deep-layer corticothalamic and 6b': '34.5', 'Deep-layer intratelencephalic': '32.1', 'Deep-layer near-projecting': '32.6', 'Eccentric medium spiny neuron': '15.9', 'Hippocampal ca1-3': '28.1', 'Hippocampal ca4': '24.2', 'Hippocampal dentate gyrus': '8.8', 'Lamp5-lhx6 and chandelier': '30.1', 'Lower rhombic lip': '52.9', 'Mammillary body': '48.3', 'Medium spiny neuron': '13.0', 'Mge interneuron': '43.5', 'Midbrain-derived inhibitory': '25.0', 'Miscellaneous': '25.8', 'Splatter': '31.7', 'Thalamic excitatory': '38.7', 'Upper rhombic lip': '12.1', 'Upper-layer intratelencephalic': '19.5', 'Astrocyte': '12.6', 'Bergmann glia': '6.4', 'Central nervous system macrophage': '36.1', 'Choroid plexus epithelial cell': '9.7', 'Committed oligodendrocyte precursor': '13.1', 'Ependymal cell': '10.0', 'Oligodendrocyte': '4.3', 'Oligodendrocyte precursor cell': '12.6', 'Endothelial cell': '7.8', 'Pericyte': '7.5', 'Vascular associated smooth muscle cell': '6.6', 'Fibroblast': '11.8', 'Leukocyte': '19.9', 'Basophil': '24.7', 'Eosinophil': '3.5', 'Neutrophil': '11.0', 'Classical monocyte': '18.5', 'Non-classical monocyte': '16.9', 'Intermediate monocyte': '56.6', 'T-reg': '4.2', 'GdT-cell': '1.8', 'MAIT T-cell': '12.6', 'Memory CD4 T-cell': '0.4', 'Naive CD4 T-cell': '5.2', 'Memory CD8 T-cell': '1.2', 'Naive CD8 T-cell': '9.2', 'Memory B-cell': '3.5', 'Naive B-cell': '6.4', 'Plasmacytoid DC': '6.5', 'Myeloid DC': '81.5', 'NK-cell': '42.6', 'Total PBMC': '27.7', 'Vd2 gdTCR': '20.2', 'Memory CD4 T-cell Th1\\/Th17': '7.1', 'Memory CD4 T-cell Th17': '7.8', 'Memory CD4 T-cell Th2': '7.5', 'Non-Vd2 gdTCR': '34.1', 'Memory CD4 T-cell Th1': '11.3', 'Memory CD4 T-cell TFH': '11.3', 'Terminal effector memory CD4 T-cell': '5.2', 'Central memory CD8 T-cell': '6.4', 'Effector memory CD8 T-cell': '16.5', 'Terminal effector memory CD8 T-cell': '26.8', 'Non-switched memory B-cell': '37.9', 'Plasmablast': '56.2', 'Switched memory B-cell': '39.9', 'Exhausted memory B-cell': '35.6', 'Progenitor cell': '9.2', 'Memory T-reg': '16.8', 'Naive CD4 T-cell activated': '2.9', 'Naive CD8 T-cell activated': '4.4', 'Naive T-reg': '8.5'}
3S95, 5HVJ, 5HVK, 5L6W, 5NXC, 6WLY, 7ATS, 7ATU, 7B8W, 8AAU
{'Adipose Tissue': 15.28206561461794, 'Adrenal Gland': 12.92075968992248, 'Bladder': 17.20495238095238, 'Blood': 24.325833261571585, 'Blood Vessel': 11.598117602996254, 'Brain': 50.049753595760784, 'Breast': 15.8179825708061, 'Cervix Uteri': 39.17368421052631, 'Colon': 11.147025673940949, 'Esophagus': 12.007795155709342, 'Fallopian Tube': 14.461111111111112, 'Heart': 5.816430545876888, 'Kidney': 9.713550561797751, 'Liver': 3.016763274336283, 'Lung': 23.49820588235294, 'Muscle': 17.295882938978828, 'Nerve': 16.242733441033927, 'Ovary': 24.44272222222222, 'Pancreas': 6.854426829268292, 'Pituitary': 23.190035335689046, 'Prostate': 21.27790204081633, 'Salivary Gland': 22.67527160493827, 'Skin': 24.38384632393587, 'Small Intestine': 18.03724064171123, 'Spleen': 32.35651452282158, 'Stomach': 10.592203342618385, 'Testis': 32.158498614958454, 'Thyroid': 21.850122511485452, 'Uterus': 22.738197183098592, 'Vagina': 25.949615384615385}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
75.523138
0.422937
1,135
O60260
P54252
22199232, hUbiquitome
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ATXN3
MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK
Homo sapiens
Nucleus matrix, Nucleus, Lysosome membrane
Low tissue specificity
{'Ciliated cells': '18.4', 'Basal respiratory cells': '29.2', 'Club cells': '29.4', 'Ionocytes': '21.7', 'Mucus glandular cells': '30.9', 'Serous glandular cells': '19.8', 'Gastric mucus-secreting cells': '11.2', 'Proximal enterocytes': '13.8', 'Paneth cells': '18.5', 'Distal enterocytes': '12.1', 'Intestinal goblet cells': '15.8', 'Exocrine glandular cells': '-0.490', 'Basal prostatic cells': '22.0', 'Prostatic glandular cells': '27.9', 'Breast glandular cells': '0.482', 'Breast myoepithelial cells': '0.474', 'Glandular and luminal cells': '22.4', 'Secretory cells': '21.4', 'Basal keratinocytes': '29.5', 'Suprabasal keratinocytes': '34.4', 'Basal squamous epithelial cells': '16.0', 'Squamous epithelial cells': '16.5', 'Alveolar cells type 1': '0.200', 'Alveolar cells type 2': '-0.407', 'Salivary duct cells': '30.6', 'Ductal cells': '0.514', 'Hepatocytes': '0.180', 'Cholangiocytes': '11.4', 'Proximal tubular cells': '0.038', 'Distal tubular cells': '3.1', 'Collecting duct cells': '37.0', 'Mesothelial cells': '0.427', 'Sertoli cells': '0.496', 'Granulosa cells': '23.1', 'Enteroendocrine cells': '11.1', 'Pancreatic endocrine cells': '13.6', 'Leydig cells': '0.480', 'Excitatory neurons': '34.9', 'Inhibitory neurons': '27.4', 'Cone photoreceptor cells': '23.8', 'Rod photoreceptor cells': '31.5', 'Bipolar cells': '22.7', 'Horizontal cells': '25.2', 'Astrocytes': '31.9', 'Oligodendrocyte precursor cells': '36.8', 'Oligodendrocytes': '47.9', 'Microglial cells': '26.8', 'Muller glia cells': '14.5', 'Schwann cells': '0.340', 'Spermatogonia': '0.407', 'Spermatocytes': '0.195', 'Early spermatids': '-0.367', 'Late spermatids': '-0.670', 'Oocytes': '51.5', 'Cytotrophoblasts': '18.5', 'Syncytiotrophoblasts': '23.8', 'Extravillous trophoblasts': '30.7', 'Endothelial cells': '50.0', 'Lymphatic endothelial cells': '81.8', 'Cardiomyocytes': '0.389', 'Skeletal myocytes': '-0.122', 'Smooth muscle cells': '39.6', 'Adipocytes': '51.4', 'Melanocytes': '0.066', 'Fibroblasts': '31.4', 'Peritubular cells': '0.602', 'Endometrial stromal cells': '33.1', 'Ovarian stromal cells': '46.4', 'Undifferentiated cells': '17.3', 'T-cells': '27.2', 'B-cells': '26.2', 'Plasma cells': '15.7', 'Nk-cells': '26.7', 'Granulocytes': '32.4', 'Monocytes': '52.0', 'Macrophages': '30.7', 'Hofbauer cells': '23.8', 'Kupffer cells': '30.1', 'Dendritic cells': '20.7', 'Langerhans cells': '0.194', 'Erythroid cells': '0.173', 'Adipocytes (Subcutaneous)': '-0.217', 'Adipocytes (Visceral)': '-0.328', 'Breast glandular cells (progenitors)': '0.330', 'Adipocytes (Breast)': '-0.414', 'Colon enterocytes': '-0.148', 'Colon enteroendocrine cells': '0.282', 'Enteric glia cells': '0.575', 'Mitotic cells (Colon)': '-0.134', 'Mitotic cells (Heart)': '0.433', 'Podocytes': '-0.080', 'Ascending Loop of Henle cells': '0.483', 'Intercalated cells': '-0.014', 'Cholangiocyte': '0.161', 'NK-cells (Liver)': '0.130', 'Respiratory ciliated cells': '0.110', 'Mitotic cells (Lung)': '-0.122', 'NK-cells (Lung)': '0.376', 'B-cells (Lung)': '0.153', 'Alpha cells': '0.408', 'Beta cells': '0.316', 'Prostate glandular cells': '-0.167', 'Prostate basal glandular cells': '0.293', 'Urothelial cells': '0.367', 'Keratinocyte (other)': '0.206', 'Keratinocyte (granular)': '-0.074', 'Hair cortex cells': '-0.187', 'Inner root sheath cells': '-0.195', 'Outer root sheath cells': '0.028', 'Sebaceous gland cells': '-0.037', 'Eccrine sweat gland cells': '-0.097', 'Adipocytes (Skin)': '-0.119', 'Mitotic cells (Skin)': '0.138', 'Parietal cells': '-0.613', 'Chief cells': '-0.508', 'Gastric mucous cells': '-0.423', 'Gastric enteroendocrine cells': '-0.291', 'Mitotic cells (Stomach)': '-0.067', 'Parafollicular cells': '0.004', 'Thyroid glandular cells': '-0.023', 'Mitotic cells (Thyroid)': '0.068', 'Adrenal cortex cells': '0.265', 'Adrenal medulla cells': '0.111', 'Mitotic cells (Adrenal gland)': '0.167', 'Minor salivary glandular cells': '0.566', 'Minor salivary gland ductal cells': '0.333', 'Minor salivary gland basal cells': '0.152', 'Mitotic cells (Minor salivary gland)': '0.184', 'Adipocytes (Minor salivary gland)': '0.218', 'Somatotropes': '-0.076', 'Lactotropes': '0.159', 'Gonadotropes': '0.155', 'Corticotropes': '-0.018', 'Thyrotropes': '0.159', 'Undifferentiated cells (Pituitary gland)': '0.191', 'Mitotic cells (Spleen)': '-0.310', 'Platelets': '-0.282', 'Erythrocytes': '-0.139', 'Hematopoietic stem cells': '-0.334', 'B-cells (Spleen)': '0.341', 'NK-cells (Spleen)': '0.385', 'Amygdala excitatory': '75.6', 'Cerebellar inhibitory': '35.7', 'Cge interneuron': '52.6', 'Deep-layer corticothalamic and 6b': '67.8', 'Deep-layer intratelencephalic': '75.3', 'Deep-layer near-projecting': '55.6', 'Eccentric medium spiny neuron': '70.0', 'Hippocampal ca1-3': '47.4', 'Hippocampal ca4': '47.6', 'Hippocampal dentate gyrus': '83.7', 'Lamp5-lhx6 and chandelier': '49.0', 'Lower rhombic lip': '59.1', 'Mammillary body': '58.3', 'Medium spiny neuron': '78.4', 'Mge interneuron': '49.6', 'Midbrain-derived inhibitory': '56.9', 'Miscellaneous': '58.3', 'Splatter': '56.1', 'Thalamic excitatory': '53.7', 'Upper rhombic lip': '60.4', 'Upper-layer intratelencephalic': '71.6', 'Astrocyte': '90.0', 'Bergmann glia': '99.8', 'Central nervous system macrophage': '106.1', 'Choroid plexus epithelial cell': '57.2', 'Committed oligodendrocyte precursor': '73.7', 'Ependymal cell': '50.0', 'Oligodendrocyte': '99.7', 'Oligodendrocyte precursor cell': '77.1', 'Endothelial cell': '91.5', 'Pericyte': '98.8', 'Vascular associated smooth muscle cell': '73.7', 'Fibroblast': '91.9', 'Leukocyte': '71.0', 'Basophil': '19.5', 'Eosinophil': '9.9', 'Neutrophil': '26.4', 'Classical monocyte': '8.7', 'Non-classical monocyte': '13.0', 'Intermediate monocyte': '28.8', 'T-reg': '20.5', 'GdT-cell': '5.2', 'MAIT T-cell': '19.1', 'Memory CD4 T-cell': '5.8', 'Naive CD4 T-cell': '13.2', 'Memory CD8 T-cell': '6.0', 'Naive CD8 T-cell': '12.3', 'Memory B-cell': '7.2', 'Naive B-cell': '13.5', 'Plasmacytoid DC': '22.0', 'Myeloid DC': '23.1', 'NK-cell': '9.3', 'Total PBMC': '17.7', 'Vd2 gdTCR': '15.5', 'Memory CD4 T-cell Th1\\/Th17': '10.9', 'Memory CD4 T-cell Th17': '9.9', 'Memory CD4 T-cell Th2': '11.7', 'Non-Vd2 gdTCR': '11.8', 'Memory CD4 T-cell Th1': '9.6', 'Memory CD4 T-cell TFH': '11.0', 'Terminal effector memory CD4 T-cell': '13.8', 'Central memory CD8 T-cell': '20.1', 'Effector memory CD8 T-cell': '15.5', 'Terminal effector memory CD8 T-cell': '15.4', 'Non-switched memory B-cell': '21.5', 'Plasmablast': '13.5', 'Switched memory B-cell': '20.6', 'Exhausted memory B-cell': '14.2', 'Progenitor cell': '23.8', 'Memory T-reg': '9.8', 'Naive CD4 T-cell activated': '8.4', 'Naive CD8 T-cell activated': '7.7', 'Naive T-reg': '15.0'}
1YZB, 2AGA, 2DOS, 2JRI, 2KLZ, 4WTH, 4YS9
{'Adipose Tissue': 4.317031395348837, 'Adrenal Gland': 1.833101937984496, 'Bladder': 3.6875238095238094, 'Blood': 1.349738686759957, 'Blood Vessel': 4.032591011235955, 'Brain': 1.7803809992429978, 'Breast': 4.653074074074074, 'Cervix Uteri': 5.303421052631579, 'Colon': 3.2107130937098844, 'Esophagus': 3.2702231833910034, 'Fallopian Tube': 4.994222222222223, 'Heart': 1.2817393728222997, 'Kidney': 1.7562314606741571, 'Liver': 1.0611615044247786, 'Lung': 4.240814878892733, 'Muscle': 0.8963214196762141, 'Nerve': 7.145966074313409, 'Ovary': 5.853211111111111, 'Pancreas': 1.2978814024390244, 'Pituitary': 3.991469964664311, 'Prostate': 4.314489795918367, 'Salivary Gland': 3.0928209876543207, 'Skin': 4.552651741293532, 'Small Intestine': 3.140152941176471, 'Spleen': 3.801773029045643, 'Stomach': 2.2698295264623956, 'Testis': 3.937642659279778, 'Thyroid': 5.4199525267993875, 'Uterus': 6.336161971830986, 'Vagina': 4.561076923076923}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
76.656593
0.509058
2,127
O60260
P54829
25583483
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PTPN5
MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLVSSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPEDRRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSHQSPE
Homo sapiens
Endoplasmic reticulum membrane
Tissue enriched (brain)
{'Ciliated cells': '0.0', 'Basal respiratory cells': '0.0', 'Club cells': '0.0', 'Ionocytes': '0.0', 'Mucus glandular cells': '0.0', 'Serous glandular cells': '0.0', 'Gastric mucus-secreting cells': '0.0', 'Proximal enterocytes': '0.0', 'Paneth cells': '0.0', 'Distal enterocytes': '0.0', 'Intestinal goblet cells': '0.0', 'Exocrine glandular cells': '-0.228', 'Basal prostatic cells': '0.1', 'Prostatic glandular cells': '0.0', 'Breast glandular cells': '0.014', 'Breast myoepithelial cells': '-0.087', 'Glandular and luminal cells': '0.0', 'Secretory cells': '0.0', 'Basal keratinocytes': '0.0', 'Suprabasal keratinocytes': '0.1', 'Basal squamous epithelial cells': '0.2', 'Squamous epithelial cells': '0.1', 'Alveolar cells type 1': '0.277', 'Alveolar cells type 2': '-0.283', 'Salivary duct cells': '0.1', 'Ductal cells': '0.204', 'Hepatocytes': '0.300', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '-0.080', 'Distal tubular cells': '0.0', 'Collecting duct cells': '0.0', 'Mesothelial cells': '-0.087', 'Sertoli cells': '0.450', 'Granulosa cells': '0.8', 'Enteroendocrine cells': '0.0', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.414', 'Excitatory neurons': '57.1', 'Inhibitory neurons': '49.7', 'Cone photoreceptor cells': '0.0', 'Rod photoreceptor cells': '0.0', 'Bipolar cells': '0.2', 'Horizontal cells': '4.4', 'Astrocytes': '4.0', 'Oligodendrocyte precursor cells': '11.8', 'Oligodendrocytes': '2.7', 'Microglial cells': '6.3', 'Muller glia cells': '0.6', 'Schwann cells': '0.129', 'Spermatogonia': '0.622', 'Spermatocytes': '0.038', 'Early spermatids': '-0.469', 'Late spermatids': '-0.506', 'Oocytes': '9.6', 'Cytotrophoblasts': '0.0', 'Syncytiotrophoblasts': '0.0', 'Extravillous trophoblasts': '0.0', 'Endothelial cells': '5.3', 'Lymphatic endothelial cells': '0.0', 'Cardiomyocytes': '-0.066', 'Skeletal myocytes': '0.030', 'Smooth muscle cells': '0.4', 'Adipocytes': '0.2', 'Melanocytes': '-0.154', 'Fibroblasts': '0.4', 'Peritubular cells': '0.396', 'Endometrial stromal cells': '0.2', 'Ovarian stromal cells': '0.2', 'Undifferentiated cells': '0.0', 'T-cells': '0.0', 'B-cells': '0.0', 'Plasma cells': '0.0', 'Nk-cells': '0.0', 'Granulocytes': '0.5', 'Monocytes': '0.0', 'Macrophages': '0.0', 'Hofbauer cells': '0.0', 'Kupffer cells': '0.0', 'Dendritic cells': '0.0', 'Langerhans cells': '-0.096', 'Erythroid cells': '-0.023', 'Adipocytes (Subcutaneous)': '-0.031', 'Adipocytes (Visceral)': '0.199', 'Breast glandular cells (progenitors)': '-0.093', 'Adipocytes (Breast)': '0.178', 'Colon enterocytes': '-0.020', 'Colon enteroendocrine cells': '0.331', 'Enteric glia cells': '0.287', 'Mitotic cells (Colon)': '-0.088', 'Mitotic cells (Heart)': '0.022', 'Podocytes': '-0.181', 'Ascending Loop of Henle cells': '0.377', 'Intercalated cells': '-0.156', 'Cholangiocyte': '0.134', 'NK-cells (Liver)': '-0.135', 'Respiratory ciliated cells': '0.003', 'Mitotic cells (Lung)': '-0.155', 'NK-cells (Lung)': '0.396', 'B-cells (Lung)': '0.199', 'Alpha cells': '0.194', 'Beta cells': '0.146', 'Prostate glandular cells': '-0.293', 'Prostate basal glandular cells': '-0.300', 'Urothelial cells': '-0.166', 'Keratinocyte (other)': '-0.367', 'Keratinocyte (granular)': '-0.231', 'Hair cortex cells': '0.299', 'Inner root sheath cells': '0.264', 'Outer root sheath cells': '0.414', 'Sebaceous gland cells': '0.205', 'Eccrine sweat gland cells': '0.386', 'Adipocytes (Skin)': '0.302', 'Mitotic cells (Skin)': '-0.103', 'Parietal cells': '-0.633', 'Chief cells': '-0.583', 'Gastric mucous cells': '-0.522', 'Gastric enteroendocrine cells': '-0.439', 'Mitotic cells (Stomach)': '-0.175', 'Parafollicular cells': '-0.114', 'Thyroid glandular cells': '0.029', 'Mitotic cells (Thyroid)': '-0.012', 'Adrenal cortex cells': '0.205', 'Adrenal medulla cells': '0.007', 'Mitotic cells (Adrenal gland)': '-0.126', 'Minor salivary glandular cells': '0.290', 'Minor salivary gland ductal cells': '0.146', 'Minor salivary gland basal cells': '0.138', 'Mitotic cells (Minor salivary gland)': '0.129', 'Adipocytes (Minor salivary gland)': '0.219', 'Somatotropes': '-0.262', 'Lactotropes': '-0.049', 'Gonadotropes': '-0.132', 'Corticotropes': '-0.053', 'Thyrotropes': '0.165', 'Undifferentiated cells (Pituitary gland)': '0.207', 'Mitotic cells (Spleen)': '-0.122', 'Platelets': '-0.095', 'Erythrocytes': '0.057', 'Hematopoietic stem cells': '-0.107', 'B-cells (Spleen)': '0.107', 'NK-cells (Spleen)': '0.156', 'Amygdala excitatory': '98.4', 'Cerebellar inhibitory': '41.4', 'Cge interneuron': '72.9', 'Deep-layer corticothalamic and 6b': '79.5', 'Deep-layer intratelencephalic': '91.9', 'Deep-layer near-projecting': '77.9', 'Eccentric medium spiny neuron': '188.1', 'Hippocampal ca1-3': '69.6', 'Hippocampal ca4': '50.9', 'Hippocampal dentate gyrus': '41.0', 'Lamp5-lhx6 and chandelier': '83.0', 'Lower rhombic lip': '63.9', 'Mammillary body': '59.9', 'Medium spiny neuron': '328.5', 'Mge interneuron': '100.1', 'Midbrain-derived inhibitory': '82.4', 'Miscellaneous': '112.5', 'Splatter': '76.9', 'Thalamic excitatory': '56.7', 'Upper rhombic lip': '12.4', 'Upper-layer intratelencephalic': '102.1', 'Astrocyte': '3.8', 'Bergmann glia': '1.4', 'Central nervous system macrophage': '3.1', 'Choroid plexus epithelial cell': '1.0', 'Committed oligodendrocyte precursor': '14.3', 'Ependymal cell': '5.2', 'Oligodendrocyte': '2.8', 'Oligodendrocyte precursor cell': '11.5', 'Endothelial cell': '4.0', 'Pericyte': '4.4', 'Vascular associated smooth muscle cell': '4.9', 'Fibroblast': '11.3', 'Leukocyte': '3.1', 'Basophil': '0.0', 'Eosinophil': '0.0', 'Neutrophil': '0.0', 'Classical monocyte': '0.0', 'Non-classical monocyte': '0.0', 'Intermediate monocyte': '0.2', 'T-reg': '0.0', 'GdT-cell': '0.0', 'MAIT T-cell': '0.2', 'Memory CD4 T-cell': '0.0', 'Naive CD4 T-cell': '0.0', 'Memory CD8 T-cell': '0.0', 'Naive CD8 T-cell': '0.0', 'Memory B-cell': '0.0', 'Naive B-cell': '0.0', 'Plasmacytoid DC': '0.0', 'Myeloid DC': '0.0', 'NK-cell': '0.0', 'Total PBMC': '0.0', 'Vd2 gdTCR': '0.0', 'Memory CD4 T-cell Th1\\/Th17': '0.0', 'Memory CD4 T-cell Th17': '0.0', 'Memory CD4 T-cell Th2': '0.0', 'Non-Vd2 gdTCR': '0.2', 'Memory CD4 T-cell Th1': '0.0', 'Memory CD4 T-cell TFH': '0.0', 'Terminal effector memory CD4 T-cell': '0.0', 'Central memory CD8 T-cell': '0.3', 'Effector memory CD8 T-cell': '0.2', 'Terminal effector memory CD8 T-cell': '0.0', 'Non-switched memory B-cell': '0.1', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.1', 'Exhausted memory B-cell': '0.1', 'Progenitor cell': '0.2', 'Memory T-reg': '0.0', 'Naive CD4 T-cell activated': '0.0', 'Naive CD8 T-cell activated': '0.0', 'Naive T-reg': '0.0'}
2BIJ, 2BV5, 2CJZ, 5OVR, 5OVX, 5OW1, 6H8R, 8SLS, 8SLT, 8SLU
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
72.033823
0.53308
1,373
O60260
P55036
19240029
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PSMD4
MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKK
Homo sapiens
null
Low tissue specificity
{'Ciliated cells': '123.3', 'Basal respiratory cells': '235.1', 'Club cells': '109.3', 'Ionocytes': '149.8', 'Mucus glandular cells': '65.0', 'Serous glandular cells': '82.4', 'Gastric mucus-secreting cells': '51.3', 'Proximal enterocytes': '165.0', 'Paneth cells': '126.8', 'Distal enterocytes': '108.5', 'Intestinal goblet cells': '82.1', 'Exocrine glandular cells': '-0.745', 'Basal prostatic cells': '80.0', 'Prostatic glandular cells': '56.6', 'Breast glandular cells': '0.026', 'Breast myoepithelial cells': '-0.184', 'Glandular and luminal cells': '63.2', 'Secretory cells': '96.5', 'Basal keratinocytes': '97.8', 'Suprabasal keratinocytes': '117.7', 'Basal squamous epithelial cells': '55.2', 'Squamous epithelial cells': '66.2', 'Alveolar cells type 1': '-0.089', 'Alveolar cells type 2': '0.026', 'Salivary duct cells': '63.1', 'Ductal cells': '0.475', 'Hepatocytes': '0.507', 'Cholangiocytes': '83.9', 'Proximal tubular cells': '0.280', 'Distal tubular cells': '132.2', 'Collecting duct cells': '64.2', 'Mesothelial cells': '0.179', 'Sertoli cells': '-0.413', 'Granulosa cells': '86.3', 'Enteroendocrine cells': '88.9', 'Pancreatic endocrine cells': '169.8', 'Leydig cells': '-0.471', 'Excitatory neurons': '24.4', 'Inhibitory neurons': '23.2', 'Cone photoreceptor cells': '71.4', 'Rod photoreceptor cells': '35.6', 'Bipolar cells': '47.2', 'Horizontal cells': '25.2', 'Astrocytes': '14.9', 'Oligodendrocyte precursor cells': '15.1', 'Oligodendrocytes': '21.6', 'Microglial cells': '10.7', 'Muller glia cells': '94.4', 'Schwann cells': '0.052', 'Spermatogonia': '-0.221', 'Spermatocytes': '0.126', 'Early spermatids': '0.738', 'Late spermatids': '0.599', 'Oocytes': '129.4', 'Cytotrophoblasts': '336.6', 'Syncytiotrophoblasts': '437.7', 'Extravillous trophoblasts': '242.8', 'Endothelial cells': '92.6', 'Lymphatic endothelial cells': '76.0', 'Cardiomyocytes': '0.686', 'Skeletal myocytes': '-0.293', 'Smooth muscle cells': '107.5', 'Adipocytes': '85.6', 'Melanocytes': '0.263', 'Fibroblasts': '92.7', 'Peritubular cells': '-0.380', 'Endometrial stromal cells': '65.0', 'Ovarian stromal cells': '120.9', 'Undifferentiated cells': '116.8', 'T-cells': '72.1', 'B-cells': '70.4', 'Plasma cells': '87.8', 'Nk-cells': '83.6', 'Granulocytes': '99.9', 'Monocytes': '104.7', 'Macrophages': '88.2', 'Hofbauer cells': '179.7', 'Kupffer cells': '89.0', 'Dendritic cells': '57.0', 'Langerhans cells': '0.267', 'Erythroid cells': '-0.094', 'Adipocytes (Subcutaneous)': '0.269', 'Adipocytes (Visceral)': '0.098', 'Breast glandular cells (progenitors)': '-0.019', 'Adipocytes (Breast)': '0.231', 'Colon enterocytes': '-0.278', 'Colon enteroendocrine cells': '0.142', 'Enteric glia cells': '-0.056', 'Mitotic cells (Colon)': '-0.302', 'Mitotic cells (Heart)': '0.461', 'Podocytes': '0.023', 'Ascending Loop of Henle cells': '0.383', 'Intercalated cells': '0.034', 'Cholangiocyte': '0.360', 'NK-cells (Liver)': '-0.351', 'Respiratory ciliated cells': '0.018', 'Mitotic cells (Lung)': '0.141', 'NK-cells (Lung)': '-0.184', 'B-cells (Lung)': '-0.263', 'Alpha cells': '0.319', 'Beta cells': '0.150', 'Prostate glandular cells': '-0.240', 'Prostate basal glandular cells': '0.024', 'Urothelial cells': '-0.065', 'Keratinocyte (other)': '0.258', 'Keratinocyte (granular)': '0.073', 'Hair cortex cells': '0.080', 'Inner root sheath cells': '0.140', 'Outer root sheath cells': '0.044', 'Sebaceous gland cells': '-0.063', 'Eccrine sweat gland cells': '-0.231', 'Adipocytes (Skin)': '-0.106', 'Mitotic cells (Skin)': '0.283', 'Parietal cells': '-0.658', 'Chief cells': '-0.495', 'Gastric mucous cells': '-0.411', 'Gastric enteroendocrine cells': '-0.454', 'Mitotic cells (Stomach)': '0.044', 'Parafollicular cells': '0.065', 'Thyroid glandular cells': '0.311', 'Mitotic cells (Thyroid)': '-0.043', 'Adrenal cortex cells': '0.428', 'Adrenal medulla cells': '0.014', 'Mitotic cells (Adrenal gland)': '0.388', 'Minor salivary glandular cells': '0.386', 'Minor salivary gland ductal cells': '-0.241', 'Minor salivary gland basal cells': '0.444', 'Mitotic cells (Minor salivary gland)': '0.625', 'Adipocytes (Minor salivary gland)': '0.260', 'Somatotropes': '0.022', 'Lactotropes': '-0.048', 'Gonadotropes': '-0.016', 'Corticotropes': '-0.129', 'Thyrotropes': '0.172', 'Undifferentiated cells (Pituitary gland)': '0.212', 'Mitotic cells (Spleen)': '-0.214', 'Platelets': '-0.075', 'Erythrocytes': '-0.097', 'Hematopoietic stem cells': '-0.071', 'B-cells (Spleen)': '0.197', 'NK-cells (Spleen)': '0.054', 'Amygdala excitatory': '37.5', 'Cerebellar inhibitory': '37.3', 'Cge interneuron': '38.4', 'Deep-layer corticothalamic and 6b': '45.3', 'Deep-layer intratelencephalic': '45.8', 'Deep-layer near-projecting': '47.4', 'Eccentric medium spiny neuron': '34.8', 'Hippocampal ca1-3': '43.1', 'Hippocampal ca4': '55.8', 'Hippocampal dentate gyrus': '40.8', 'Lamp5-lhx6 and chandelier': '40.2', 'Lower rhombic lip': '66.2', 'Mammillary body': '38.5', 'Medium spiny neuron': '33.8', 'Mge interneuron': '43.4', 'Midbrain-derived inhibitory': '41.3', 'Miscellaneous': '42.1', 'Splatter': '41.6', 'Thalamic excitatory': '49.2', 'Upper rhombic lip': '36.8', 'Upper-layer intratelencephalic': '41.1', 'Astrocyte': '27.9', 'Bergmann glia': '24.6', 'Central nervous system macrophage': '34.7', 'Choroid plexus epithelial cell': '30.8', 'Committed oligodendrocyte precursor': '32.2', 'Ependymal cell': '33.2', 'Oligodendrocyte': '39.1', 'Oligodendrocyte precursor cell': '28.9', 'Endothelial cell': '33.4', 'Pericyte': '41.8', 'Vascular associated smooth muscle cell': '45.6', 'Fibroblast': '28.7', 'Leukocyte': '34.6', 'Basophil': '221.1', 'Eosinophil': '715.7', 'Neutrophil': '401.8', 'Classical monocyte': '80.2', 'Non-classical monocyte': '103.0', 'Intermediate monocyte': '319.7', 'T-reg': '206.3', 'GdT-cell': '247.9', 'MAIT T-cell': '185.8', 'Memory CD4 T-cell': '288.2', 'Naive CD4 T-cell': '59.7', 'Memory CD8 T-cell': '274.5', 'Naive CD8 T-cell': '58.7', 'Memory B-cell': '400.6', 'Naive B-cell': '44.5', 'Plasmacytoid DC': '238.7', 'Myeloid DC': '268.4', 'NK-cell': '79.3', 'Total PBMC': '288.6', 'Vd2 gdTCR': '203.5', 'Memory CD4 T-cell Th1\\/Th17': '61.3', 'Memory CD4 T-cell Th17': '74.8', 'Memory CD4 T-cell Th2': '70.2', 'Non-Vd2 gdTCR': '202.1', 'Memory CD4 T-cell Th1': '72.3', 'Memory CD4 T-cell TFH': '81.4', 'Terminal effector memory CD4 T-cell': '169.6', 'Central memory CD8 T-cell': '167.0', 'Effector memory CD8 T-cell': '215.4', 'Terminal effector memory CD8 T-cell': '201.9', 'Non-switched memory B-cell': '232.4', 'Plasmablast': '330.3', 'Switched memory B-cell': '242.4', 'Exhausted memory B-cell': '206.9', 'Progenitor cell': '170.6', 'Memory T-reg': '101.8', 'Naive CD4 T-cell activated': '89.2', 'Naive CD8 T-cell activated': '109.6', 'Naive T-reg': '65.3'}
1P9C, 1P9D, 1UEL, 1YX4, 1YX5, 1YX6, 2KDE, 2KDF, 5GJQ, 5GJR, 5L4K, 5LN3, 5M32, 5T0C, 5T0G, 5T0H, 5T0I, 5T0J, 5VFP, 5VFQ, 5VFR, 5VFS, 5VFT, 5VFU, 5VGZ, 5VHF, 5VHH, 5VHI, 5VHS, 6MSB, 6MSD, 6MSE, 6MSG, 6MSH, 6MSJ, 6MSK, 6MUN, 6U19, 6WJD, 6WJN, 7QXN, 7QXP, 7QXU, 7QXW, 7QXX, 7QY7, 7QYA, 7QYB, 7W37, 7W38, 7W39, 7W3A, 7W3B, 7W3C, 7W3F, 7W3G, 7W3H, 7W3I, 7W3J, 7W3K, 7W3M, 8CVT
{'Adipose Tissue': 130.58397009966777, 'Adrenal Gland': 112.06674418604652, 'Bladder': 161.34428571428572, 'Blood': 126.73810548977394, 'Blood Vessel': 178.44722097378278, 'Brain': 112.51081377744131, 'Breast': 127.58614379084968, 'Cervix Uteri': 142.29999999999998, 'Colon': 142.35978177150193, 'Esophagus': 144.21247750865052, 'Fallopian Tube': 150.96666666666667, 'Heart': 80.91817421602786, 'Kidney': 76.30786516853932, 'Liver': 73.51946902654868, 'Lung': 124.86148788927336, 'Muscle': 230.68657534246577, 'Nerve': 157.01793214862684, 'Ovary': 133.57011111111112, 'Pancreas': 49.08298780487805, 'Pituitary': 104.81685512367493, 'Prostate': 122.1535918367347, 'Salivary Gland': 92.65753086419754, 'Skin': 135.96165284687672, 'Small Intestine': 108.37374331550802, 'Spleen': 133.20697095435685, 'Stomach': 106.43529247910864, 'Testis': 233.95706371191136, 'Thyroid': 121.93591117917305, 'Uterus': 160.2387323943662, 'Vagina': 125.9401282051282}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
72.068806
0.487294
2,061
O60260
P55072
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
VCP
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGSVYTEDNDDDLYG
Homo sapiens
Cytoplasm, cytosol, Endoplasmic reticulum, Nucleus, Cytoplasm, Stress granule
Low tissue specificity
{'Ciliated cells': '114.5', 'Basal respiratory cells': '146.0', 'Club cells': '118.3', 'Ionocytes': '95.4', 'Mucus glandular cells': '129.7', 'Serous glandular cells': '134.1', 'Gastric mucus-secreting cells': '131.5', 'Proximal enterocytes': '75.7', 'Paneth cells': '61.1', 'Distal enterocytes': '102.0', 'Intestinal goblet cells': '76.4', 'Exocrine glandular cells': '-0.609', 'Basal prostatic cells': '96.7', 'Prostatic glandular cells': '147.2', 'Breast glandular cells': '-0.106', 'Breast myoepithelial cells': '-0.170', 'Glandular and luminal cells': '107.9', 'Secretory cells': '86.2', 'Basal keratinocytes': '125.2', 'Suprabasal keratinocytes': '175.6', 'Basal squamous epithelial cells': '104.4', 'Squamous epithelial cells': '128.4', 'Alveolar cells type 1': '0.005', 'Alveolar cells type 2': '0.140', 'Salivary duct cells': '115.6', 'Ductal cells': '0.606', 'Hepatocytes': '0.586', 'Cholangiocytes': '51.5', 'Proximal tubular cells': '0.286', 'Distal tubular cells': '52.2', 'Collecting duct cells': '64.2', 'Mesothelial cells': '0.067', 'Sertoli cells': '0.357', 'Granulosa cells': '56.1', 'Enteroendocrine cells': '74.1', 'Pancreatic endocrine cells': '195.3', 'Leydig cells': '0.399', 'Excitatory neurons': '26.5', 'Inhibitory neurons': '26.5', 'Cone photoreceptor cells': '134.2', 'Rod photoreceptor cells': '99.2', 'Bipolar cells': '103.0', 'Horizontal cells': '79.9', 'Astrocytes': '21.7', 'Oligodendrocyte precursor cells': '17.5', 'Oligodendrocytes': '29.3', 'Microglial cells': '16.1', 'Muller glia cells': '91.5', 'Schwann cells': '-0.003', 'Spermatogonia': '0.717', 'Spermatocytes': '0.680', 'Early spermatids': '-0.138', 'Late spermatids': '-0.353', 'Oocytes': '35.3', 'Cytotrophoblasts': '274.8', 'Syncytiotrophoblasts': '595.8', 'Extravillous trophoblasts': '165.8', 'Endothelial cells': '118.0', 'Lymphatic endothelial cells': '108.3', 'Cardiomyocytes': '0.711', 'Skeletal myocytes': '-0.258', 'Smooth muscle cells': '100.3', 'Adipocytes': '84.0', 'Melanocytes': '0.336', 'Fibroblasts': '123.9', 'Peritubular cells': '0.224', 'Endometrial stromal cells': '88.7', 'Ovarian stromal cells': '59.0', 'Undifferentiated cells': '71.0', 'T-cells': '104.2', 'B-cells': '119.6', 'Plasma cells': '262.4', 'Nk-cells': '79.3', 'Granulocytes': '112.6', 'Monocytes': '85.6', 'Macrophages': '98.6', 'Hofbauer cells': '117.0', 'Kupffer cells': '79.0', 'Dendritic cells': '103.5', 'Langerhans cells': '0.267', 'Erythroid cells': '-0.132', 'Adipocytes (Subcutaneous)': '0.313', 'Adipocytes (Visceral)': '0.274', 'Breast glandular cells (progenitors)': '-0.146', 'Adipocytes (Breast)': '0.374', 'Colon enterocytes': '-0.084', 'Colon enteroendocrine cells': '0.116', 'Enteric glia cells': '-0.323', 'Mitotic cells (Colon)': '0.001', 'Mitotic cells (Heart)': '0.482', 'Podocytes': '-0.088', 'Ascending Loop of Henle cells': '0.315', 'Intercalated cells': '-0.062', 'Cholangiocyte': '0.298', 'NK-cells (Liver)': '-0.364', 'Respiratory ciliated cells': '-0.114', 'Mitotic cells (Lung)': '0.168', 'NK-cells (Lung)': '0.018', 'B-cells (Lung)': '-0.130', 'Alpha cells': '0.365', 'Beta cells': '0.215', 'Prostate glandular cells': '0.116', 'Prostate basal glandular cells': '0.104', 'Urothelial cells': '-0.082', 'Keratinocyte (other)': '0.248', 'Keratinocyte (granular)': '0.008', 'Hair cortex cells': '0.275', 'Inner root sheath cells': '0.305', 'Outer root sheath cells': '0.269', 'Sebaceous gland cells': '0.127', 'Eccrine sweat gland cells': '-0.169', 'Adipocytes (Skin)': '-0.124', 'Mitotic cells (Skin)': '0.383', 'Parietal cells': '-0.555', 'Chief cells': '-0.502', 'Gastric mucous cells': '-0.136', 'Gastric enteroendocrine cells': '-0.390', 'Mitotic cells (Stomach)': '0.319', 'Parafollicular cells': '0.083', 'Thyroid glandular cells': '0.301', 'Mitotic cells (Thyroid)': '0.009', 'Adrenal cortex cells': '0.487', 'Adrenal medulla cells': '0.047', 'Mitotic cells (Adrenal gland)': '0.417', 'Minor salivary glandular cells': '0.226', 'Minor salivary gland ductal cells': '-0.224', 'Minor salivary gland basal cells': '0.520', 'Mitotic cells (Minor salivary gland)': '0.595', 'Adipocytes (Minor salivary gland)': '0.086', 'Somatotropes': '0.120', 'Lactotropes': '0.186', 'Gonadotropes': '0.276', 'Corticotropes': '0.068', 'Thyrotropes': '0.272', 'Undifferentiated cells (Pituitary gland)': '0.013', 'Mitotic cells (Spleen)': '0.158', 'Platelets': '0.073', 'Erythrocytes': '-0.090', 'Hematopoietic stem cells': '0.016', 'B-cells (Spleen)': '0.127', 'NK-cells (Spleen)': '-0.070', 'Amygdala excitatory': '47.1', 'Cerebellar inhibitory': '52.4', 'Cge interneuron': '53.7', 'Deep-layer corticothalamic and 6b': '51.0', 'Deep-layer intratelencephalic': '52.9', 'Deep-layer near-projecting': '54.1', 'Eccentric medium spiny neuron': '48.4', 'Hippocampal ca1-3': '49.5', 'Hippocampal ca4': '68.6', 'Hippocampal dentate gyrus': '56.7', 'Lamp5-lhx6 and chandelier': '55.2', 'Lower rhombic lip': '58.5', 'Mammillary body': '50.4', 'Medium spiny neuron': '44.1', 'Mge interneuron': '50.2', 'Midbrain-derived inhibitory': '58.4', 'Miscellaneous': '44.9', 'Splatter': '58.9', 'Thalamic excitatory': '53.9', 'Upper rhombic lip': '55.9', 'Upper-layer intratelencephalic': '42.3', 'Astrocyte': '50.0', 'Bergmann glia': '54.2', 'Central nervous system macrophage': '55.5', 'Choroid plexus epithelial cell': '64.6', 'Committed oligodendrocyte precursor': '55.8', 'Ependymal cell': '43.0', 'Oligodendrocyte': '57.0', 'Oligodendrocyte precursor cell': '43.3', 'Endothelial cell': '98.3', 'Pericyte': '76.1', 'Vascular associated smooth muscle cell': '68.7', 'Fibroblast': '56.4', 'Leukocyte': '62.9', 'Basophil': '181.0', 'Eosinophil': '75.1', 'Neutrophil': '146.1', 'Classical monocyte': '188.6', 'Non-classical monocyte': '145.3', 'Intermediate monocyte': '83.1', 'T-reg': '81.5', 'GdT-cell': '58.8', 'MAIT T-cell': '76.7', 'Memory CD4 T-cell': '59.2', 'Naive CD4 T-cell': '108.8', 'Memory CD8 T-cell': '65.4', 'Naive CD8 T-cell': '100.1', 'Memory B-cell': '59.3', 'Naive B-cell': '92.6', 'Plasmacytoid DC': '126.2', 'Myeloid DC': '90.1', 'NK-cell': '195.5', 'Total PBMC': '89.7', 'Vd2 gdTCR': '88.3', 'Memory CD4 T-cell Th1\\/Th17': '140.6', 'Memory CD4 T-cell Th17': '154.7', 'Memory CD4 T-cell Th2': '162.3', 'Non-Vd2 gdTCR': '104.3', 'Memory CD4 T-cell Th1': '152.2', 'Memory CD4 T-cell TFH': '161.4', 'Terminal effector memory CD4 T-cell': '111.5', 'Central memory CD8 T-cell': '84.3', 'Effector memory CD8 T-cell': '104.2', 'Terminal effector memory CD8 T-cell': '109.1', 'Non-switched memory B-cell': '103.8', 'Plasmablast': '312.5', 'Switched memory B-cell': '117.8', 'Exhausted memory B-cell': '117.4', 'Progenitor cell': '98.7', 'Memory T-reg': '203.7', 'Naive CD4 T-cell activated': '271.6', 'Naive CD8 T-cell activated': '275.9', 'Naive T-reg': '116.5'}
3EBB, 3HU1, 3HU2, 3HU3, 3QC8, 3QQ7, 3QQ8, 3QWZ, 3TIW, 4KDI, 4KDL, 4KLN, 4KO8, 4KOD, 4P0A, 5B6C, 5C18, 5C19, 5C1A, 5C1B, 5DYG, 5DYI, 5EPP, 5FTJ, 5FTK, 5FTL, 5FTM, 5FTN, 5GLF, 5IFS, 5IFW, 5KIW, 5KIY, 5X4L, 6G2V, 6G2W, 6G2X, 6G2Y, 6G2Z, 6G30, 6HD0, 6MCK, 7BP8, 7BP9, 7BPA, 7BPB, 7JY5, 7K56, 7K57, 7K59, 7L5W, 7L5X, 7LMY, 7LMZ, 7LN0, 7LN1, 7LN2, 7LN3, 7LN4, 7LN5, 7LN6, 7MDM, 7MDO, 7MHS, 7OAT, 7PUX, 7R7S, 7R7T, 7R7U, 7RL6, 7RL7, 7RL9, 7RLA, 7RLB, 7RLC, 7RLD, 7RLF, 7RLG, 7RLH, 7RLI, 7RLJ, 7VCS, 7VCT, 7VCU, 7VCV, 7VCX, 7Y4W, 7Y53, 7Y59, 8B5R, 8FCL, 8FCM, 8FCN, 8FCO, 8FCP, 8FCQ, 8FCR, 8FCT, 8HL7, 8HRZ, 8KG2, 8OOI, 8PQX, 8R0E, 8RS9, 8RSB, 8RSC, 8VKU, 8VLS, 8VOV
{'Adipose Tissue': 145.10239202657806, 'Adrenal Gland': 167.8136434108527, 'Bladder': 156.3761904761905, 'Blood': 89.89988482238967, 'Blood Vessel': 166.62775280898876, 'Brain': 65.75532929598788, 'Breast': 136.64884531590414, 'Cervix Uteri': 158.2736842105263, 'Colon': 116.618729139923, 'Esophagus': 145.54085121107266, 'Fallopian Tube': 159.41111111111113, 'Heart': 100.82308594657374, 'Kidney': 77.32325842696629, 'Liver': 78.63217699115044, 'Lung': 171.05686851211073, 'Muscle': 204.81033623910335, 'Nerve': 160.07423263327948, 'Ovary': 138.83561111111112, 'Pancreas': 48.3807012195122, 'Pituitary': 143.51787985865724, 'Prostate': 139.25844897959183, 'Salivary Gland': 137.46104938271606, 'Skin': 175.70694306246546, 'Small Intestine': 120.7403743315508, 'Spleen': 151.39697095435685, 'Stomach': 106.11894150417828, 'Testis': 143.0014681440443, 'Thyroid': 154.06546707503827, 'Uterus': 175.02, 'Vagina': 151.60782051282052}
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[1.0, 1.0, 1.0, 1.0, 1.0, 0.82, 0.97, 0.81, 0.87, 0.68, 0.57, 0.81, 0.73, 0.42, 0.48, 0.89, 0.79, 0.54, 0.82, 0.86, 0.8, 0.69, 0.4, 0.24, 0.66, 0.01, 0.36, 0.02, 0.23, 0.37, 0.4, 0.62, 0.39, 0.53, 0.28, 0.13, 0.07, 0.12, 0.0, 0.11, 0.0, 0.03, 0.42, 0.56, 0.1, 0.03, 0.59, 0.55, 0.13, 0.78, 0.05, 0.7, 0.74, 0.52, 0.33, 0.18, 0.0, 0.1, 0.0, 0.32, 0.33, 0.44, 0.64, 0.92, 0.32, 0.22, 0.02, 0.04, 0.03, 0.2, 0.0, 0.24, 0.38, 0.16, 0.85, 0.63, 0.07, 0.51, 0.46, 0.7, 0.35, 0.0, 0.15, 0.01, 0.16, 0.11, 0.06, 0.02, 0.08, 0.16, 0.11, 0.0, 0.22, 0.06, 0.22, 0.08, 0.32, 0.09, 0.47, 0.02, 0.23, 0.02, 0.41, 0.54, 0.09, 0.87, 0.76, 0.13, 0.69, 0.57, 0.04, 0.67, 0.61, 0.02, 0.3, 0.01, 0.1, 0.08, 0.0, 0.36, 0.55, 0.02, 0.09, 0.75, 0.49, 0.19, 0.43, 0.61, 0.39, 0.19, 0.32, 0.45, 0.09, 0.02, 0.0, 0.45, 0.54, 0.16, 0.08, 0.71, 0.8, 0.31, 0.45, 0.13, 0.05, 0.06, 0.23, 0.43, 0.31, 0.1, 0.09, 0.06, 0.13, 0.07, 0.4, 0.14, 0.06, 0.25, 0.25, 0.16, 0.0, 0.01, 0.01, 0.13, 0.02, 0.38, 0.48, 0.05, 0.28, 0.27, 0.62, 0.51, 0.27, 0.01, 0.11, 0.02, 0.08, 0.7, 0.73, 0.1, 0.48, 0.2, 0.5, 0.28, 0.84, 0.67, 0.87, 0.43, 0.2, 0.83, 0.2, 0.48, 0.98, 0.46, 0.08, 0.45, 0.2, 0.13, 0.57, 0.42, 0.21, 0.0, 0.03, 0.38, 0.32, 0.14, 0.22, 0.31, 0.09, 0.71, 0.82, 0.29, 0.09, 0.4, 0.47, 0.0, 0.17, 0.61, 0.15, 0.0, 0.24, 0.4, 0.09, 0.13, 0.33, 0.52, 0.35, 0.7, 0.47, 0.23, 0.85, 0.82, 0.64, 0.7, 0.58, 0.76, 0.36, 0.16, 0.19, 0.0, 0.0, 0.0, 0.0, 0.23, 0.11, 0.08, 0.48, 0.35, 0.12, 0.3, 0.09, 0.3, 0.37, 0.01, 0.0, 0.38, 0.0, 0.0, 0.04, 0.28, 0.07, 0.1, 0.48, 0.12, 0.3, 0.25, 0.23, 0.44, 0.04, 0.4, 0.0, 0.39, 0.53, 0.07, 0.3, 0.78, 0.38, 0.72, 0.21, 0.58, 0.48, 0.01, 0.15, 0.33, 0.27, 0.0, 0.34, 0.56, 0.01, 0.07, 0.51, 0.41, 0.0, 0.41, 0.78, 0.42, 0.42, 0.41, 0.0, 0.0, 0.0, 0.0, 0.0, 0.22, 0.46, 0.0, 0.23, 0.31, 0.0, 0.0, 0.2, 0.35, 0.5, 0.9, 0.69, 0.03, 0.87, 0.28, 0.74, 0.39, 0.33, 0.48, 0.47, 0.03, 0.03, 0.41, 0.2, 0.01, 0.08, 0.62, 0.16, 0.0, 0.48, 0.6, 0.12, 0.63, 0.51, 0.88, 0.1, 0.39, 0.13, 0.04, 0.0, 0.0, 0.0, 0.01, 0.01, 0.41, 0.71, 0.22, 0.57, 0.19, 0.02, 0.06, 0.57, 0.25, 0.0, 0.37, 0.74, 0.85, 0.24, 0.17, 0.01, 0.31, 0.56, 0.4, 0.01, 0.48, 0.02, 0.38, 0.27, 0.1, 0.65, 0.32, 0.61, 0.02, 0.05, 0.23, 0.16, 0.09, 0.0, 0.47, 0.18, 0.4, 0.07, 0.22, 0.31, 0.19, 0.43, 0.32, 0.26, 0.96, 0.55, 0.19, 0.43, 0.12, 0.59, 0.36, 0.0, 0.01, 0.58, 0.52, 0.0, 0.22, 0.03, 0.05, 0.01, 0.18, 0.45, 0.09, 0.0, 0.21, 0.49, 0.02, 0.01, 0.5, 0.31, 0.0, 0.07, 0.43, 0.16, 0.03, 0.27, 0.45, 0.53, 0.31, 0.48, 0.88, 0.72, 0.2, 0.56, 0.74, 0.86, 0.59, 0.92, 0.44, 0.4, 0.41, 0.02, 0.52, 0.32, 0.18, 0.28, 0.48, 0.02, 0.3, 0.0, 0.33, 0.03, 0.53, 0.01, 0.0, 0.49, 0.34, 0.02, 0.18, 0.74, 0.65, 0.25, 0.68, 0.2, 0.32, 0.27, 0.14, 0.64, 0.82, 0.25, 0.66, 0.07, 0.41, 0.22, 0.02, 0.82, 0.19, 0.3, 0.12, 0.67, 0.31, 0.09, 0.14, 0.09, 0.14, 0.59, 0.64, 0.07, 0.09, 0.56, 0.37, 0.0, 0.26, 0.46, 0.17, 0.03, 0.12, 0.45, 0.1, 0.3, 0.6, 0.47, 0.47, 0.67, 0.6, 0.24, 0.79, 0.85, 0.7, 0.75, 0.61, 0.83, 0.29, 0.22, 0.22, 0.02, 0.04, 0.03, 0.0, 0.05, 0.0, 0.02, 0.4, 0.38, 0.1, 0.23, 0.05, 0.35, 0.45, 0.0, 0.0, 0.22, 0.01, 0.0, 0.0, 0.13, 0.41, 0.13, 0.66, 0.03, 0.12, 0.01, 0.01, 0.37, 0.02, 0.51, 0.01, 0.4, 0.4, 0.02, 0.42, 0.73, 0.29, 0.74, 0.76, 0.91, 0.5, 0.16, 0.33, 0.49, 0.21, 0.01, 0.39, 0.39, 0.05, 0.0, 0.31, 0.18, 0.0, 0.21, 0.53, 0.06, 0.42, 0.32, 0.0, 0.0, 0.0, 0.0, 0.04, 0.17, 0.47, 0.05, 0.2, 0.39, 0.06, 0.01, 0.54, 0.44, 0.63, 0.88, 0.94, 0.89, 0.99, 0.57, 0.88, 0.65, 0.38, 0.33, 0.18, 0.17, 0.33, 0.57, 0.02, 0.04, 0.42, 0.11, 0.09, 0.07, 0.59, 0.12, 0.04, 0.48, 0.62, 0.04, 0.5, 0.4, 0.9, 0.51, 0.34, 0.09, 0.1, 0.02, 0.01, 0.0, 0.03, 0.01, 0.29, 0.5, 0.07, 0.75, 0.21, 0.08, 0.09, 0.6, 0.16, 0.07, 0.26, 0.66, 0.88, 0.3, 0.15, 0.02, 0.25, 0.27, 0.2, 0.01, 0.27, 0.0, 0.39, 0.21, 0.14, 0.54, 0.44, 0.8, 0.16, 0.05, 0.14, 0.33, 0.13, 0.02, 0.47, 0.18, 0.32, 0.1, 0.51, 0.91, 0.33, 0.51, 0.31, 0.11, 0.94, 0.39, 0.15, 0.51, 0.16, 0.47, 0.56, 0.09, 0.0, 0.59, 0.57, 0.01, 0.63, 0.15, 0.09, 0.01, 0.17, 0.45, 0.08, 0.0, 0.3, 0.49, 0.02, 0.06, 0.48, 0.36, 0.0, 0.29, 0.58, 0.24, 0.07, 0.49, 0.6, 0.32, 0.18, 0.48, 0.53, 0.29, 0.53, 0.46, 0.65, 0.45, 0.49, 0.67, 0.56, 0.48, 0.67, 0.76, 0.57, 0.79, 0.79, 0.69, 0.85, 0.82, 0.8, 0.89, 0.69, 0.76, 0.55, 0.47, 0.1, 0.59, 0.51, 0.04, 0.32, 0.45, 0.51, 0.05, 0.03, 0.57, 0.35, 0.01, 0.25, 0.78, 0.54, 0.28, 0.84, 0.4, 0.62, 0.04, 0.44, 0.52, 0.67, 0.36, 0.2, 0.59, 0.64, 0.13, 0.48, 0.57, 0.26, 0.08, 0.58, 0.6, 0.17, 0.68, 0.76, 0.69, 0.58, 0.71, 0.94, 0.99, 0.92, 0.75, 0.92, 0.79, 0.89, 0.93, 0.91, 0.98, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.98, 1.0, 1.0, 1.0, 1.0, 1.0, 0.95, 1.0, 0.98, 1.0, 0.99, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
82.822295
0.361725
750
O60260
P55209
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
NAP1L1
MADIDNKEQSELDQDLDDVEEVEEEETGEETKLKARQLTVQMMQNPQILAALQERLDGLVETPTGYIESLPRVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKPDEEDEISEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFVLEFHFEPNEYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPESGDLDDDAEAILAADFEIGHFLRERIIPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ
Homo sapiens
Nucleus, Melanosome, Cytoplasm
Low tissue specificity
{'Ciliated cells': '307.7', 'Basal respiratory cells': '454.4', 'Club cells': '210.5', 'Ionocytes': '218.7', 'Mucus glandular cells': '319.5', 'Serous glandular cells': '236.1', 'Gastric mucus-secreting cells': '70.2', 'Proximal enterocytes': '5.9', 'Paneth cells': '58.5', 'Distal enterocytes': '21.8', 'Intestinal goblet cells': '121.5', 'Exocrine glandular cells': '-0.671', 'Basal prostatic cells': '247.9', 'Prostatic glandular cells': '157.7', 'Breast glandular cells': '0.171', 'Breast myoepithelial cells': '-0.017', 'Glandular and luminal cells': '218.6', 'Secretory cells': '290.8', 'Basal keratinocytes': '426.6', 'Suprabasal keratinocytes': '272.1', 'Basal squamous epithelial cells': '362.1', 'Squamous epithelial cells': '232.4', 'Alveolar cells type 1': '0.012', 'Alveolar cells type 2': '-0.376', 'Salivary duct cells': '553.0', 'Ductal cells': '0.667', 'Hepatocytes': '0.414', 'Cholangiocytes': '183.2', 'Proximal tubular cells': '0.058', 'Distal tubular cells': '267.4', 'Collecting duct cells': '151.7', 'Mesothelial cells': '0.101', 'Sertoli cells': '0.574', 'Granulosa cells': '408.1', 'Enteroendocrine cells': '162.3', 'Pancreatic endocrine cells': '397.3', 'Leydig cells': '0.611', 'Excitatory neurons': '175.8', 'Inhibitory neurons': '142.7', 'Cone photoreceptor cells': '98.6', 'Rod photoreceptor cells': '118.2', 'Bipolar cells': '129.7', 'Horizontal cells': '196.4', 'Astrocytes': '73.4', 'Oligodendrocyte precursor cells': '86.8', 'Oligodendrocytes': '101.8', 'Microglial cells': '89.5', 'Muller glia cells': '361.8', 'Schwann cells': '0.086', 'Spermatogonia': '0.483', 'Spermatocytes': '0.175', 'Early spermatids': '-0.386', 'Late spermatids': '-0.689', 'Oocytes': '372.0', 'Cytotrophoblasts': '568.1', 'Syncytiotrophoblasts': '396.9', 'Extravillous trophoblasts': '465.6', 'Endothelial cells': '310.4', 'Lymphatic endothelial cells': '288.0', 'Cardiomyocytes': '0.590', 'Skeletal myocytes': '-0.371', 'Smooth muscle cells': '357.8', 'Adipocytes': '201.1', 'Melanocytes': '-0.146', 'Fibroblasts': '333.1', 'Peritubular cells': '0.545', 'Endometrial stromal cells': '860.1', 'Ovarian stromal cells': '909.3', 'Undifferentiated cells': '312.0', 'T-cells': '407.6', 'B-cells': '561.2', 'Plasma cells': '222.0', 'Nk-cells': '262.5', 'Granulocytes': '395.6', 'Monocytes': '2067.3', 'Macrophages': '431.7', 'Hofbauer cells': '493.9', 'Kupffer cells': '471.5', 'Dendritic cells': '490.4', 'Langerhans cells': '-0.011', 'Erythroid cells': '0.066', 'Adipocytes (Subcutaneous)': '0.217', 'Adipocytes (Visceral)': '-0.050', 'Breast glandular cells (progenitors)': '0.195', 'Adipocytes (Breast)': '0.047', 'Colon enterocytes': '-0.299', 'Colon enteroendocrine cells': '0.171', 'Enteric glia cells': '0.268', 'Mitotic cells (Colon)': '-0.111', 'Mitotic cells (Heart)': '0.469', 'Podocytes': '0.041', 'Ascending Loop of Henle cells': '0.374', 'Intercalated cells': '0.014', 'Cholangiocyte': '0.502', 'NK-cells (Liver)': '-0.268', 'Respiratory ciliated cells': '-0.027', 'Mitotic cells (Lung)': '-0.060', 'NK-cells (Lung)': '0.009', 'B-cells (Lung)': '-0.017', 'Alpha cells': '0.404', 'Beta cells': '0.217', 'Prostate glandular cells': '-0.536', 'Prostate basal glandular cells': '-0.146', 'Urothelial cells': '0.044', 'Keratinocyte (other)': '-0.353', 'Keratinocyte (granular)': '-0.277', 'Hair cortex cells': '0.129', 'Inner root sheath cells': '0.228', 'Outer root sheath cells': '0.279', 'Sebaceous gland cells': '0.148', 'Eccrine sweat gland cells': '0.302', 'Adipocytes (Skin)': '0.286', 'Mitotic cells (Skin)': '0.084', 'Parietal cells': '-0.759', 'Chief cells': '-0.539', 'Gastric mucous cells': '-0.584', 'Gastric enteroendocrine cells': '-0.414', 'Mitotic cells (Stomach)': '-0.127', 'Parafollicular cells': '0.044', 'Thyroid glandular cells': '0.146', 'Mitotic cells (Thyroid)': '0.103', 'Adrenal cortex cells': '0.425', 'Adrenal medulla cells': '-0.096', 'Mitotic cells (Adrenal gland)': '0.030', 'Minor salivary glandular cells': '0.729', 'Minor salivary gland ductal cells': '0.244', 'Minor salivary gland basal cells': '0.138', 'Mitotic cells (Minor salivary gland)': '0.270', 'Adipocytes (Minor salivary gland)': '0.241', 'Somatotropes': '-0.036', 'Lactotropes': '-0.101', 'Gonadotropes': '-0.035', 'Corticotropes': '-0.137', 'Thyrotropes': '0.143', 'Undifferentiated cells (Pituitary gland)': '0.267', 'Mitotic cells (Spleen)': '-0.234', 'Platelets': '-0.276', 'Erythrocytes': '-0.143', 'Hematopoietic stem cells': '-0.269', 'B-cells (Spleen)': '0.452', 'NK-cells (Spleen)': '0.280', 'Amygdala excitatory': '223.7', 'Cerebellar inhibitory': '213.0', 'Cge interneuron': '218.2', 'Deep-layer corticothalamic and 6b': '231.7', 'Deep-layer intratelencephalic': '224.5', 'Deep-layer near-projecting': '219.9', 'Eccentric medium spiny neuron': '338.7', 'Hippocampal ca1-3': '256.8', 'Hippocampal ca4': '241.6', 'Hippocampal dentate gyrus': '264.4', 'Lamp5-lhx6 and chandelier': '257.8', 'Lower rhombic lip': '203.8', 'Mammillary body': '193.5', 'Medium spiny neuron': '318.9', 'Mge interneuron': '215.0', 'Midbrain-derived inhibitory': '188.6', 'Miscellaneous': '272.7', 'Splatter': '194.3', 'Thalamic excitatory': '249.8', 'Upper rhombic lip': '185.7', 'Upper-layer intratelencephalic': '244.0', 'Astrocyte': '124.3', 'Bergmann glia': '119.1', 'Central nervous system macrophage': '214.0', 'Choroid plexus epithelial cell': '135.2', 'Committed oligodendrocyte precursor': '138.2', 'Ependymal cell': '173.1', 'Oligodendrocyte': '157.1', 'Oligodendrocyte precursor cell': '162.4', 'Endothelial cell': '123.3', 'Pericyte': '182.3', 'Vascular associated smooth muscle cell': '206.0', 'Fibroblast': '217.1', 'Leukocyte': '168.1', 'Basophil': '9.3', 'Eosinophil': '183.9', 'Neutrophil': '44.8', 'Classical monocyte': '68.9', 'Non-classical monocyte': '448.1', 'Intermediate monocyte': '1130.9', 'T-reg': '440.3', 'GdT-cell': '95.1', 'MAIT T-cell': '414.4', 'Memory CD4 T-cell': '219.1', 'Naive CD4 T-cell': '181.6', 'Memory CD8 T-cell': '154.3', 'Naive CD8 T-cell': '160.1', 'Memory B-cell': '248.7', 'Naive B-cell': '161.8', 'Plasmacytoid DC': '410.1', 'Myeloid DC': '563.2', 'NK-cell': '49.2', 'Total PBMC': '445.8', 'Vd2 gdTCR': '351.7', 'Memory CD4 T-cell Th1\\/Th17': '159.8', 'Memory CD4 T-cell Th17': '150.9', 'Memory CD4 T-cell Th2': '153.7', 'Non-Vd2 gdTCR': '274.7', 'Memory CD4 T-cell Th1': '123.9', 'Memory CD4 T-cell TFH': '131.3', 'Terminal effector memory CD4 T-cell': '305.2', 'Central memory CD8 T-cell': '460.1', 'Effector memory CD8 T-cell': '347.5', 'Terminal effector memory CD8 T-cell': '243.5', 'Non-switched memory B-cell': '410.8', 'Plasmablast': '364.9', 'Switched memory B-cell': '648.7', 'Exhausted memory B-cell': '448.0', 'Progenitor cell': '403.2', 'Memory T-reg': '103.6', 'Naive CD4 T-cell activated': '230.9', 'Naive CD8 T-cell activated': '217.2', 'Naive T-reg': '172.7'}
7BP5, 7UN3, 7UN6
{'Adipose Tissue': 68.28593272425249, 'Adrenal Gland': 49.24395348837209, 'Bladder': 69.14952380952381, 'Blood': 45.968398277717974, 'Blood Vessel': 73.325468164794, 'Brain': 40.126165404996215, 'Breast': 67.6485403050109, 'Cervix Uteri': 110.06210526315787, 'Colon': 51.79040564826701, 'Esophagus': 54.90023391003461, 'Fallopian Tube': 82.19222222222221, 'Heart': 29.028042973286876, 'Kidney': 25.962123595505616, 'Liver': 9.129597345132744, 'Lung': 93.71437716262976, 'Muscle': 51.01107098381071, 'Nerve': 82.36749596122779, 'Ovary': 161.08083333333332, 'Pancreas': 15.879185975609754, 'Pituitary': 49.21862190812721, 'Prostate': 65.80995918367347, 'Salivary Gland': 39.06777777777778, 'Skin': 53.959778883360975, 'Small Intestine': 48.9017807486631, 'Spleen': 57.97195020746888, 'Stomach': 34.10425348189415, 'Testis': 40.88631578947368, 'Thyroid': 53.28583460949464, 'Uterus': 96.5338028169014, 'Vagina': 72.25294871794871}
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[40.94, 40.89, 43.66, 42.5, 53.52, 41.56, 50.05, 44.24, 40.57, 42.93, 42.27, 41.72, 38.41, 41.29, 42.49, 36.03, 42.33, 36.21, 40.12, 34.04, 34.17, 33.2, 32.73, 35.85, 33.67, 43.12, 43.7, 50.75, 50.8, 52.43, 56.63, 62.97, 66.34, 68.63, 61.62, 68.34, 68.6, 69.47, 65.84, 72.89, 71.75, 65.71, 68.35, 75.78, 77.02, 74.1, 80.02, 74.69, 71.35, 75.32, 74.38, 68.4, 66.29, 72.26, 62.31, 58.18, 56.49, 53.67, 53.46, 52.91, 51.82, 49.39, 52.41, 55.03, 68.77, 83.2, 83.47, 86.04, 89.43, 91.4, 94.81, 94.55, 96.72, 95.55, 94.31, 96.67, 97.99, 95.61, 94.89, 97.68, 97.79, 95.83, 95.42, 97.38, 96.11, 94.54, 95.66, 95.4, 93.99, 93.92, 95.04, 94.97, 93.37, 93.71, 95.83, 94.05, 91.86, 94.04, 94.26, 92.92, 93.73, 95.87, 94.5, 94.35, 95.91, 96.89, 95.7, 96.1, 97.24, 96.93, 97.0, 97.97, 97.81, 98.22, 98.25, 97.96, 98.21, 98.17, 98.02, 97.6, 97.63, 96.7, 95.84, 96.18, 96.05, 95.02, 94.7, 94.43, 91.45, 91.36, 91.92, 90.4, 89.09, 82.42, 80.84, 71.93, 61.47, 59.25, 55.6, 55.84, 53.61, 52.57, 58.8, 55.41, 51.66, 51.47, 55.06, 51.87, 42.09, 44.32, 41.52, 35.46, 35.73, 42.99, 42.3, 45.07, 37.22, 47.29, 47.0, 47.71, 53.69, 61.69, 67.65, 74.99, 83.16, 92.07, 95.55, 94.04, 95.99, 98.33, 98.52, 98.2, 98.02, 98.07, 97.6, 96.75, 95.41, 94.1, 92.61, 91.95, 95.48, 95.45, 94.15, 95.43, 97.73, 98.0, 97.69, 97.3, 98.51, 98.32, 98.29, 98.57, 98.39, 97.69, 98.0, 98.43, 97.98, 98.6, 98.66, 98.32, 97.87, 96.91, 96.43, 95.26, 93.82, 90.89, 88.5, 91.78, 91.84, 93.92, 96.25, 97.45, 98.41, 98.76, 98.78, 98.8, 98.72, 98.61, 97.02, 98.15, 97.98, 98.34, 98.64, 98.67, 98.56, 98.6, 98.49, 98.73, 98.85, 98.66, 98.58, 98.23, 98.03, 96.13, 94.16, 90.29, 89.48, 88.45, 88.82, 88.56, 87.73, 89.62, 90.87, 89.52, 90.43, 90.06, 90.56, 90.17, 91.83, 91.61, 91.39, 93.67, 91.25, 93.89, 97.03, 97.15, 97.86, 97.75, 97.96, 98.61, 98.53, 98.56, 98.37, 96.47, 94.22, 97.69, 97.79, 97.87, 97.65, 96.64, 93.47, 89.87, 88.65, 88.19, 86.63, 85.35, 80.31, 78.04, 75.05, 69.43, 74.17, 73.99, 74.02, 73.62, 78.63, 82.69, 82.17, 83.41, 85.12, 89.89, 89.28, 92.75, 93.38, 96.4, 96.2, 97.82, 97.91, 98.37, 97.39, 97.84, 98.34, 97.01, 95.7, 93.37, 88.88, 87.92, 85.6, 83.02, 85.2, 81.7, 86.03, 87.29, 92.62, 93.74, 93.13, 93.49, 93.75, 94.37, 93.92, 95.74, 94.61, 94.88, 97.09, 96.29, 95.65, 96.21, 97.23, 95.35, 95.68, 97.45, 95.72, 94.29, 94.74, 96.91, 97.89, 96.91, 96.28, 97.35, 97.1, 96.2, 96.55, 97.39, 95.99, 92.77, 91.34, 89.21, 83.14, 68.17, 65.18, 63.32, 57.83, 51.37, 52.51, 49.56, 43.4, 42.11, 43.29, 43.27, 36.43, 37.09, 41.03, 43.06, 40.47, 42.81, 44.98, 38.81, 46.4, 40.48, 42.59, 42.23, 40.48, 48.57, 43.54, 53.83, 52.92, 61.91, 53.01, 57.91, 53.42, 51.66, 46.65, 47.76, 47.93, 49.69, 46.02, 55.1, 50.65, 58.74, 57.56, 55.65, 49.37]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
79.094322
0.539105
2,008
O60260
P56937
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
HSD17B7
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
Homo sapiens
Endoplasmic reticulum membrane
Tissue enhanced (liver)
{'Ciliated cells': '12.2', 'Basal respiratory cells': '43.5', 'Club cells': '21.2', 'Ionocytes': '22.5', 'Mucus glandular cells': '6.5', 'Serous glandular cells': '13.6', 'Gastric mucus-secreting cells': '7.1', 'Proximal enterocytes': '9.5', 'Paneth cells': '6.6', 'Distal enterocytes': '17.5', 'Intestinal goblet cells': '14.7', 'Exocrine glandular cells': '-0.465', 'Basal prostatic cells': '9.5', 'Prostatic glandular cells': '10.3', 'Breast glandular cells': '0.602', 'Breast myoepithelial cells': '0.577', 'Glandular and luminal cells': '6.9', 'Secretory cells': '8.3', 'Basal keratinocytes': '13.3', 'Suprabasal keratinocytes': '19.3', 'Basal squamous epithelial cells': '24.6', 'Squamous epithelial cells': '10.8', 'Alveolar cells type 1': '-0.119', 'Alveolar cells type 2': '0.352', 'Salivary duct cells': '9.3', 'Ductal cells': '0.511', 'Hepatocytes': '0.080', 'Cholangiocytes': '7.6', 'Proximal tubular cells': '0.209', 'Distal tubular cells': '3.1', 'Collecting duct cells': '11.7', 'Mesothelial cells': '0.440', 'Sertoli cells': '0.274', 'Granulosa cells': '13.8', 'Enteroendocrine cells': '10.3', 'Pancreatic endocrine cells': '10.2', 'Leydig cells': '0.499', 'Excitatory neurons': '8.1', 'Inhibitory neurons': '8.7', 'Cone photoreceptor cells': '18.7', 'Rod photoreceptor cells': '51.8', 'Bipolar cells': '18.8', 'Horizontal cells': '12.6', 'Astrocytes': '21.4', 'Oligodendrocyte precursor cells': '11.8', 'Oligodendrocytes': '21.0', 'Microglial cells': '5.4', 'Muller glia cells': '9.4', 'Schwann cells': '0.009', 'Spermatogonia': '0.197', 'Spermatocytes': '-0.163', 'Early spermatids': '-0.389', 'Late spermatids': '-0.512', 'Oocytes': '5.9', 'Cytotrophoblasts': '16.9', 'Syncytiotrophoblasts': '17.0', 'Extravillous trophoblasts': '14.0', 'Endothelial cells': '10.1', 'Lymphatic endothelial cells': '11.5', 'Cardiomyocytes': '0.370', 'Skeletal myocytes': '0.123', 'Smooth muscle cells': '8.2', 'Adipocytes': '6.5', 'Melanocytes': '0.070', 'Fibroblasts': '9.0', 'Peritubular cells': '0.476', 'Endometrial stromal cells': '5.6', 'Ovarian stromal cells': '16.9', 'Undifferentiated cells': '11.7', 'T-cells': '19.1', 'B-cells': '15.2', 'Plasma cells': '15.1', 'Nk-cells': '15.3', 'Granulocytes': '6.3', 'Monocytes': '7.8', 'Macrophages': '10.5', 'Hofbauer cells': '10.4', 'Kupffer cells': '6.0', 'Dendritic cells': '7.7', 'Langerhans cells': '0.174', 'Erythroid cells': '0.076', 'Adipocytes (Subcutaneous)': '-0.290', 'Adipocytes (Visceral)': '-0.375', 'Breast glandular cells (progenitors)': '0.372', 'Adipocytes (Breast)': '-0.731', 'Colon enterocytes': '-0.170', 'Colon enteroendocrine cells': '0.175', 'Enteric glia cells': '0.347', 'Mitotic cells (Colon)': '0.072', 'Mitotic cells (Heart)': '0.477', 'Podocytes': '-0.105', 'Ascending Loop of Henle cells': '0.360', 'Intercalated cells': '-0.108', 'Cholangiocyte': '0.072', 'NK-cells (Liver)': '-0.066', 'Respiratory ciliated cells': '0.034', 'Mitotic cells (Lung)': '0.091', 'NK-cells (Lung)': '-0.170', 'B-cells (Lung)': '-0.078', 'Alpha cells': '0.340', 'Beta cells': '0.265', 'Prostate glandular cells': '0.087', 'Prostate basal glandular cells': '0.369', 'Urothelial cells': '0.488', 'Keratinocyte (other)': '0.190', 'Keratinocyte (granular)': '-0.130', 'Hair cortex cells': '-0.122', 'Inner root sheath cells': '-0.044', 'Outer root sheath cells': '0.181', 'Sebaceous gland cells': '0.177', 'Eccrine sweat gland cells': '-0.057', 'Adipocytes (Skin)': '-0.224', 'Mitotic cells (Skin)': '0.362', 'Parietal cells': '-0.421', 'Chief cells': '-0.330', 'Gastric mucous cells': '-0.024', 'Gastric enteroendocrine cells': '-0.162', 'Mitotic cells (Stomach)': '0.234', 'Parafollicular cells': '-0.002', 'Thyroid glandular cells': '0.107', 'Mitotic cells (Thyroid)': '0.068', 'Adrenal cortex cells': '0.473', 'Adrenal medulla cells': '0.056', 'Mitotic cells (Adrenal gland)': '0.161', 'Minor salivary glandular cells': '0.197', 'Minor salivary gland ductal cells': '0.178', 'Minor salivary gland basal cells': '0.369', 'Mitotic cells (Minor salivary gland)': '0.307', 'Adipocytes (Minor salivary gland)': '0.260', 'Somatotropes': '-0.002', 'Lactotropes': '-0.228', 'Gonadotropes': '-0.169', 'Corticotropes': '0.158', 'Thyrotropes': '0.076', 'Undifferentiated cells (Pituitary gland)': '-0.028', 'Mitotic cells (Spleen)': '-0.068', 'Platelets': '-0.313', 'Erythrocytes': '-0.049', 'Hematopoietic stem cells': '-0.309', 'B-cells (Spleen)': '0.435', 'NK-cells (Spleen)': '0.369', 'Amygdala excitatory': '10.4', 'Cerebellar inhibitory': '11.4', 'Cge interneuron': '12.8', 'Deep-layer corticothalamic and 6b': '15.2', 'Deep-layer intratelencephalic': '15.5', 'Deep-layer near-projecting': '15.4', 'Eccentric medium spiny neuron': '12.1', 'Hippocampal ca1-3': '17.9', 'Hippocampal ca4': '19.1', 'Hippocampal dentate gyrus': '10.0', 'Lamp5-lhx6 and chandelier': '13.6', 'Lower rhombic lip': '10.5', 'Mammillary body': '9.6', 'Medium spiny neuron': '9.8', 'Mge interneuron': '10.1', 'Midbrain-derived inhibitory': '17.9', 'Miscellaneous': '10.9', 'Splatter': '15.6', 'Thalamic excitatory': '16.4', 'Upper rhombic lip': '8.5', 'Upper-layer intratelencephalic': '9.1', 'Astrocyte': '18.0', 'Bergmann glia': '12.5', 'Central nervous system macrophage': '22.0', 'Choroid plexus epithelial cell': '16.7', 'Committed oligodendrocyte precursor': '24.6', 'Ependymal cell': '9.4', 'Oligodendrocyte': '33.5', 'Oligodendrocyte precursor cell': '23.0', 'Endothelial cell': '12.9', 'Pericyte': '6.9', 'Vascular associated smooth muscle cell': '5.7', 'Fibroblast': '11.4', 'Leukocyte': '18.9', 'Basophil': '39.1', 'Eosinophil': '12.0', 'Neutrophil': '21.5', 'Classical monocyte': '3.1', 'Non-classical monocyte': '8.1', 'Intermediate monocyte': '18.4', 'T-reg': '21.6', 'GdT-cell': '13.9', 'MAIT T-cell': '28.3', 'Memory CD4 T-cell': '10.1', 'Naive CD4 T-cell': '14.5', 'Memory CD8 T-cell': '14.1', 'Naive CD8 T-cell': '15.1', 'Memory B-cell': '12.4', 'Naive B-cell': '14.3', 'Plasmacytoid DC': '35.8', 'Myeloid DC': '22.0', 'NK-cell': '13.7', 'Total PBMC': '21.7', 'Vd2 gdTCR': '29.3', 'Memory CD4 T-cell Th1\\/Th17': '12.4', 'Memory CD4 T-cell Th17': '12.1', 'Memory CD4 T-cell Th2': '13.6', 'Non-Vd2 gdTCR': '22.4', 'Memory CD4 T-cell Th1': '11.8', 'Memory CD4 T-cell TFH': '11.4', 'Terminal effector memory CD4 T-cell': '21.6', 'Central memory CD8 T-cell': '22.3', 'Effector memory CD8 T-cell': '32.4', 'Terminal effector memory CD8 T-cell': '27.7', 'Non-switched memory B-cell': '28.9', 'Plasmablast': '30.9', 'Switched memory B-cell': '28.1', 'Exhausted memory B-cell': '27.1', 'Progenitor cell': '20.6', 'Memory T-reg': '13.4', 'Naive CD4 T-cell activated': '8.9', 'Naive CD8 T-cell activated': '10.7', 'Naive T-reg': '16.3'}
null
{'Adipose Tissue': 6.855348006644518, 'Adrenal Gland': 18.504368217054264, 'Bladder': 8.105857142857143, 'Blood': 7.086790419806244, 'Blood Vessel': 6.527396254681649, 'Brain': 4.982531226343679, 'Breast': 9.296769063180829, 'Cervix Uteri': 13.370526315789473, 'Colon': 8.921012836970474, 'Esophagus': 7.280037370242215, 'Fallopian Tube': 7.919777777777777, 'Heart': 2.3281544715447153, 'Kidney': 5.677505617977528, 'Liver': 22.845150442477877, 'Lung': 14.549465397923877, 'Muscle': 1.0436104607721046, 'Nerve': 10.8822859450727, 'Ovary': 14.325005555555556, 'Pancreas': 3.4636219512195123, 'Pituitary': 16.866936395759716, 'Prostate': 11.70885306122449, 'Salivary Gland': 7.759092592592593, 'Skin': 8.334915422885572, 'Small Intestine': 9.211657754010696, 'Spleen': 10.258464730290456, 'Stomach': 6.739178272980501, 'Testis': 4.714451523545706, 'Thyroid': 11.576914241960184, 'Uterus': 10.459830985915492, 'Vagina': 12.280166666666666}
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[78.2, 92.07, 95.51, 97.78, 98.48, 98.79, 98.81, 98.69, 96.44, 97.39, 94.25, 91.78, 91.38, 94.78, 96.69, 97.02, 97.25, 98.19, 98.5, 98.04, 97.65, 98.14, 97.57, 96.44, 95.11, 94.84, 93.48, 95.18, 96.78, 97.97, 98.37, 98.62, 98.71, 98.61, 97.99, 96.18, 95.17, 97.32, 97.45, 96.27, 97.81, 98.54, 98.17, 98.24, 98.37, 98.32, 98.14, 98.11, 97.81, 97.52, 96.78, 97.16, 95.55, 94.12, 96.08, 97.39, 98.04, 97.99, 98.67, 98.64, 98.67, 98.55, 97.93, 97.35, 96.1, 96.6, 96.94, 95.27, 97.7, 98.37, 97.28, 97.76, 98.59, 98.51, 98.36, 98.54, 98.63, 98.11, 97.78, 97.06, 96.86, 94.4, 95.86, 97.76, 97.37, 98.04, 98.64, 98.8, 98.64, 97.81, 95.02, 93.37, 90.92, 85.57, 72.44, 64.9, 66.88, 64.53, 67.45, 71.96, 69.13, 71.61, 72.82, 72.09, 72.12, 71.35, 68.52, 70.84, 74.93, 73.31, 72.85, 72.69, 68.17, 67.5, 67.8, 67.3, 68.47, 62.78, 65.12, 66.23, 69.4, 66.99, 68.63, 71.64, 66.03, 71.42, 72.38, 82.98, 90.58, 93.79, 94.81, 91.68, 93.29, 94.58, 96.69, 96.66, 95.87, 95.79, 97.59, 97.91, 97.27, 97.59, 98.56, 98.54, 98.44, 98.65, 98.67, 98.49, 98.61, 98.3, 97.64, 97.87, 98.16, 96.68, 96.03, 96.99, 96.16, 89.26, 88.02, 79.8, 86.35, 90.8, 95.14, 97.49, 97.97, 98.59, 98.66, 98.55, 97.32, 95.94, 92.34, 88.52, 86.1, 92.0, 88.92, 93.52, 92.87, 90.62, 95.71, 96.24, 95.97, 95.85, 96.42, 96.67, 96.56, 94.94, 93.4, 90.72, 86.75, 86.95, 88.66, 92.81, 92.57, 92.29, 94.84, 96.9, 96.35, 97.31, 98.09, 98.09, 98.26, 98.47, 98.56, 98.55, 98.36, 98.4, 98.21, 97.98, 96.7, 96.84, 96.96, 96.11, 94.5, 95.39, 96.07, 97.75, 98.18, 98.41, 98.45, 98.25, 97.9, 95.75, 92.59, 85.41, 80.79, 75.78, 69.21, 66.85, 63.38, 66.54, 64.66, 64.32, 67.16, 70.62, 72.16, 75.28, 76.56, 79.84, 79.96, 77.69, 81.08, 83.31, 82.58, 83.64, 85.7, 83.24, 80.94, 83.23, 84.41, 79.3, 82.1, 82.08, 82.17, 81.08, 80.21, 81.27, 82.44, 84.65, 83.38, 88.93, 91.98, 94.35, 94.02, 93.91, 96.41, 97.22, 97.69, 98.12, 98.01, 97.91, 98.04, 97.38, 96.48, 96.55, 95.74, 96.43, 94.75, 96.11, 97.29, 96.9, 96.64, 97.36, 97.53, 96.99, 97.75, 96.13, 96.26, 93.2, 91.9, 90.95, 86.09, 87.99, 87.42, 92.53, 94.41, 95.35, 95.23, 94.91, 95.57, 94.31, 95.99, 95.47, 94.5, 95.34, 92.33, 95.81, 96.81, 96.94, 98.08, 98.06, 98.32, 98.44, 98.53, 98.41, 98.35, 98.55, 98.31, 97.88, 97.76, 97.65, 97.02, 95.73, 94.06, 93.51, 92.75, 90.17, 86.16, 85.24, 86.47, 82.63, 80.51, 80.77, 77.37, 77.66, 76.57, 74.86, 72.07, 59.48, 56.1, 48.8, 38.7]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
90.325748
0.292434
2,213
O60260
P60228
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
EIF3E
MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY
Homo sapiens
Cytoplasm, Nucleus, PML body
Low tissue specificity
{'Ciliated cells': '179.9', 'Basal respiratory cells': '994.6', 'Club cells': '348.7', 'Ionocytes': '473.1', 'Mucus glandular cells': '191.5', 'Serous glandular cells': '344.9', 'Gastric mucus-secreting cells': '222.3', 'Proximal enterocytes': '281.1', 'Paneth cells': '369.4', 'Distal enterocytes': '159.2', 'Intestinal goblet cells': '314.8', 'Exocrine glandular cells': '-0.556', 'Basal prostatic cells': '281.0', 'Prostatic glandular cells': '214.7', 'Breast glandular cells': '0.388', 'Breast myoepithelial cells': '0.439', 'Glandular and luminal cells': '215.6', 'Secretory cells': '508.5', 'Basal keratinocytes': '712.1', 'Suprabasal keratinocytes': '748.5', 'Basal squamous epithelial cells': '752.1', 'Squamous epithelial cells': '498.1', 'Alveolar cells type 1': '0.086', 'Alveolar cells type 2': '-0.353', 'Salivary duct cells': '225.6', 'Ductal cells': '0.525', 'Hepatocytes': '0.436', 'Cholangiocytes': '335.8', 'Proximal tubular cells': '0.133', 'Distal tubular cells': '663.9', 'Collecting duct cells': '163.4', 'Mesothelial cells': '0.412', 'Sertoli cells': '0.136', 'Granulosa cells': '429.9', 'Enteroendocrine cells': '316.4', 'Pancreatic endocrine cells': '360.0', 'Leydig cells': '0.289', 'Excitatory neurons': '35.1', 'Inhibitory neurons': '34.6', 'Cone photoreceptor cells': '110.4', 'Rod photoreceptor cells': '74.2', 'Bipolar cells': '75.7', 'Horizontal cells': '32.1', 'Astrocytes': '35.0', 'Oligodendrocyte precursor cells': '56.1', 'Oligodendrocytes': '64.4', 'Microglial cells': '35.8', 'Muller glia cells': '123.2', 'Schwann cells': '0.112', 'Spermatogonia': '0.278', 'Spermatocytes': '0.248', 'Early spermatids': '0.250', 'Late spermatids': '-0.306', 'Oocytes': '194.1', 'Cytotrophoblasts': '643.0', 'Syncytiotrophoblasts': '615.9', 'Extravillous trophoblasts': '799.2', 'Endothelial cells': '322.0', 'Lymphatic endothelial cells': '317.5', 'Cardiomyocytes': '0.620', 'Skeletal myocytes': '-0.201', 'Smooth muscle cells': '360.2', 'Adipocytes': '265.1', 'Melanocytes': '0.011', 'Fibroblasts': '316.9', 'Peritubular cells': '0.383', 'Endometrial stromal cells': '352.3', 'Ovarian stromal cells': '991.7', 'Undifferentiated cells': '671.0', 'T-cells': '437.0', 'B-cells': '558.9', 'Plasma cells': '266.5', 'Nk-cells': '292.7', 'Granulocytes': '442.8', 'Monocytes': '561.1', 'Macrophages': '318.4', 'Hofbauer cells': '491.4', 'Kupffer cells': '606.0', 'Dendritic cells': '371.5', 'Langerhans cells': '0.221', 'Erythroid cells': '-0.027', 'Adipocytes (Subcutaneous)': '-0.134', 'Adipocytes (Visceral)': '-0.357', 'Breast glandular cells (progenitors)': '0.433', 'Adipocytes (Breast)': '-0.348', 'Colon enterocytes': '-0.337', 'Colon enteroendocrine cells': '0.199', 'Enteric glia cells': '0.240', 'Mitotic cells (Colon)': '-0.220', 'Mitotic cells (Heart)': '0.448', 'Podocytes': '0.210', 'Ascending Loop of Henle cells': '0.264', 'Intercalated cells': '0.184', 'Cholangiocyte': '0.385', 'NK-cells (Liver)': '-0.260', 'Respiratory ciliated cells': '0.043', 'Mitotic cells (Lung)': '-0.018', 'NK-cells (Lung)': '0.115', 'B-cells (Lung)': '0.061', 'Alpha cells': '0.258', 'Beta cells': '0.122', 'Prostate glandular cells': '-0.310', 'Prostate basal glandular cells': '-0.003', 'Urothelial cells': '0.156', 'Keratinocyte (other)': '0.140', 'Keratinocyte (granular)': '-0.142', 'Hair cortex cells': '-0.114', 'Inner root sheath cells': '0.022', 'Outer root sheath cells': '0.150', 'Sebaceous gland cells': '0.087', 'Eccrine sweat gland cells': '0.075', 'Adipocytes (Skin)': '-0.061', 'Mitotic cells (Skin)': '0.217', 'Parietal cells': '-0.624', 'Chief cells': '-0.363', 'Gastric mucous cells': '-0.539', 'Gastric enteroendocrine cells': '-0.329', 'Mitotic cells (Stomach)': '-0.146', 'Parafollicular cells': '0.053', 'Thyroid glandular cells': '0.280', 'Mitotic cells (Thyroid)': '0.093', 'Adrenal cortex cells': '0.318', 'Adrenal medulla cells': '-0.050', 'Mitotic cells (Adrenal gland)': '0.221', 'Minor salivary glandular cells': '0.479', 'Minor salivary gland ductal cells': '0.114', 'Minor salivary gland basal cells': '0.316', 'Mitotic cells (Minor salivary gland)': '0.377', 'Adipocytes (Minor salivary gland)': '0.222', 'Somatotropes': '0.376', 'Lactotropes': '0.222', 'Gonadotropes': '-0.016', 'Corticotropes': '-0.011', 'Thyrotropes': '0.129', 'Undifferentiated cells (Pituitary gland)': '-0.119', 'Mitotic cells (Spleen)': '-0.127', 'Platelets': '-0.294', 'Erythrocytes': '-0.151', 'Hematopoietic stem cells': '-0.191', 'B-cells (Spleen)': '0.439', 'NK-cells (Spleen)': '0.275', 'Amygdala excitatory': '83.4', 'Cerebellar inhibitory': '80.9', 'Cge interneuron': '56.6', 'Deep-layer corticothalamic and 6b': '81.2', 'Deep-layer intratelencephalic': '64.9', 'Deep-layer near-projecting': '64.6', 'Eccentric medium spiny neuron': '76.3', 'Hippocampal ca1-3': '78.7', 'Hippocampal ca4': '91.3', 'Hippocampal dentate gyrus': '128.9', 'Lamp5-lhx6 and chandelier': '56.4', 'Lower rhombic lip': '69.8', 'Mammillary body': '84.7', 'Medium spiny neuron': '92.3', 'Mge interneuron': '65.7', 'Midbrain-derived inhibitory': '60.0', 'Miscellaneous': '77.6', 'Splatter': '70.4', 'Thalamic excitatory': '70.7', 'Upper rhombic lip': '87.9', 'Upper-layer intratelencephalic': '77.9', 'Astrocyte': '252.9', 'Bergmann glia': '218.5', 'Central nervous system macrophage': '110.2', 'Choroid plexus epithelial cell': '124.6', 'Committed oligodendrocyte precursor': '85.5', 'Ependymal cell': '113.5', 'Oligodendrocyte': '124.2', 'Oligodendrocyte precursor cell': '98.1', 'Endothelial cell': '100.7', 'Pericyte': '88.4', 'Vascular associated smooth muscle cell': '106.5', 'Fibroblast': '91.1', 'Leukocyte': '112.1', 'Basophil': '35.5', 'Eosinophil': '32.5', 'Neutrophil': '3.7', 'Classical monocyte': '198.2', 'Non-classical monocyte': '173.8', 'Intermediate monocyte': '153.3', 'T-reg': '218.6', 'GdT-cell': '104.2', 'MAIT T-cell': '191.7', 'Memory CD4 T-cell': '206.0', 'Naive CD4 T-cell': '478.1', 'Memory CD8 T-cell': '148.2', 'Naive CD8 T-cell': '389.2', 'Memory B-cell': '215.3', 'Naive B-cell': '240.2', 'Plasmacytoid DC': '199.4', 'Myeloid DC': '243.5', 'NK-cell': '93.7', 'Total PBMC': '205.1', 'Vd2 gdTCR': '172.2', 'Memory CD4 T-cell TFH': '230.4', 'Memory CD4 T-cell Th2': '324.6', 'Memory CD4 T-cell Th17': '339.4', 'Memory CD4 T-cell Th1\\/Th17': '366.5', 'Non-Vd2 gdTCR': '135.2', 'Memory CD4 T-cell Th1': '246.0', 'Terminal effector memory CD4 T-cell': '125.0', 'Central memory CD8 T-cell': '205.6', 'Effector memory CD8 T-cell': '168.7', 'Terminal effector memory CD8 T-cell': '112.8', 'Switched memory B-cell': '205.6', 'Plasmablast': '265.3', 'Non-switched memory B-cell': '176.7', 'Exhausted memory B-cell': '147.5', 'Progenitor cell': '306.3', 'Naive CD4 T-cell activated': '302.6', 'Naive CD8 T-cell activated': '282.7', 'Memory T-reg': '164.0', 'Naive T-reg': '345.3'}
3J8B, 3J8C, 6FEC, 6YBD, 6ZMW, 6ZON, 6ZP4, 6ZVJ, 7A09, 7QP6, 7QP7, 8OZ0, 8PPL, 8XXN
{'Adipose Tissue': 186.48178405315613, 'Adrenal Gland': 110.82980620155038, 'Bladder': 197.8380952380953, 'Blood': 101.49227341227126, 'Blood Vessel': 203.03011985018728, 'Brain': 54.901751324753974, 'Breast': 185.4181045751634, 'Cervix Uteri': 323.4157894736842, 'Colon': 170.82245186136072, 'Esophagus': 152.83722491349482, 'Fallopian Tube': 245.54444444444445, 'Heart': 54.73121254355401, 'Kidney': 79.13943820224719, 'Liver': 40.90646902654867, 'Lung': 147.85039792387542, 'Muscle': 106.9576587795766, 'Nerve': 158.1385460420032, 'Ovary': 388.2883333333333, 'Pancreas': 106.8159756097561, 'Pituitary': 120.45547703180212, 'Prostate': 163.58367346938775, 'Salivary Gland': 134.65493827160492, 'Skin': 183.3972305140962, 'Small Intestine': 128.0929411764706, 'Spleen': 108.87452282157676, 'Stomach': 129.14593314763232, 'Testis': 77.71545706371191, 'Thyroid': 144.30169984686063, 'Uterus': 266.2507042253521, 'Vagina': 222.2730769230769}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
64.84809
0.372404
1,786
O60260
P61201
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
COPS2
MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
Homo sapiens
Cytoplasm, Nucleus
Low tissue specificity
{'Ciliated cells': '37.0', 'Basal respiratory cells': '82.2', 'Club cells': '46.9', 'Ionocytes': '37.9', 'Mucus glandular cells': '46.3', 'Serous glandular cells': '41.2', 'Gastric mucus-secreting cells': '36.0', 'Proximal enterocytes': '36.5', 'Paneth cells': '19.7', 'Distal enterocytes': '23.3', 'Intestinal goblet cells': '28.8', 'Exocrine glandular cells': '-0.637', 'Basal prostatic cells': '68.5', 'Prostatic glandular cells': '43.4', 'Breast glandular cells': '0.241', 'Breast myoepithelial cells': '0.332', 'Glandular and luminal cells': '97.6', 'Secretory cells': '67.8', 'Basal keratinocytes': '78.3', 'Suprabasal keratinocytes': '89.8', 'Basal squamous epithelial cells': '77.8', 'Squamous epithelial cells': '59.6', 'Alveolar cells type 1': '0.084', 'Alveolar cells type 2': '-0.439', 'Salivary duct cells': '52.6', 'Ductal cells': '0.435', 'Hepatocytes': '0.370', 'Cholangiocytes': '28.6', 'Proximal tubular cells': '0.184', 'Distal tubular cells': '43.0', 'Collecting duct cells': '27.2', 'Mesothelial cells': '0.311', 'Sertoli cells': '0.515', 'Granulosa cells': '50.3', 'Enteroendocrine cells': '21.0', 'Pancreatic endocrine cells': '59.4', 'Leydig cells': '0.490', 'Excitatory neurons': '34.0', 'Inhibitory neurons': '34.5', 'Cone photoreceptor cells': '10.2', 'Rod photoreceptor cells': '18.7', 'Bipolar cells': '21.8', 'Horizontal cells': '24.5', 'Astrocytes': '13.6', 'Oligodendrocyte precursor cells': '20.3', 'Oligodendrocytes': '45.3', 'Microglial cells': '18.8', 'Muller glia cells': '25.5', 'Schwann cells': '0.066', 'Spermatogonia': '0.483', 'Spermatocytes': '0.325', 'Early spermatids': '0.005', 'Late spermatids': '-0.514', 'Oocytes': '88.2', 'Cytotrophoblasts': '56.8', 'Syncytiotrophoblasts': '137.6', 'Extravillous trophoblasts': '73.5', 'Endothelial cells': '52.4', 'Lymphatic endothelial cells': '58.9', 'Cardiomyocytes': '0.624', 'Skeletal myocytes': '-0.271', 'Smooth muscle cells': '64.6', 'Adipocytes': '67.4', 'Melanocytes': '0.123', 'Fibroblasts': '71.1', 'Peritubular cells': '0.378', 'Endometrial stromal cells': '91.3', 'Ovarian stromal cells': '69.1', 'Undifferentiated cells': '35.9', 'T-cells': '55.6', 'B-cells': '44.9', 'Plasma cells': '65.0', 'Nk-cells': '52.5', 'Granulocytes': '80.8', 'Monocytes': '111.9', 'Macrophages': '48.1', 'Hofbauer cells': '41.6', 'Kupffer cells': '41.0', 'Dendritic cells': '55.8', 'Langerhans cells': '0.166', 'Erythroid cells': '-0.042', 'Adipocytes (Subcutaneous)': '-0.047', 'Adipocytes (Visceral)': '-0.292', 'Breast glandular cells (progenitors)': '0.127', 'Adipocytes (Breast)': '-0.279', 'Colon enterocytes': '-0.243', 'Colon enteroendocrine cells': '0.224', 'Enteric glia cells': '0.111', 'Mitotic cells (Colon)': '-0.119', 'Mitotic cells (Heart)': '0.473', 'Podocytes': '0.158', 'Ascending Loop of Henle cells': '0.306', 'Intercalated cells': '0.111', 'Cholangiocyte': '0.350', 'NK-cells (Liver)': '-0.297', 'Respiratory ciliated cells': '0.014', 'Mitotic cells (Lung)': '-0.110', 'NK-cells (Lung)': '0.206', 'B-cells (Lung)': '0.108', 'Alpha cells': '0.281', 'Beta cells': '0.130', 'Prostate glandular cells': '-0.366', 'Prostate basal glandular cells': '-0.082', 'Urothelial cells': '0.056', 'Keratinocyte (other)': '0.138', 'Keratinocyte (granular)': '-0.143', 'Hair cortex cells': '-0.073', 'Inner root sheath cells': '0.055', 'Outer root sheath cells': '0.152', 'Sebaceous gland cells': '-0.001', 'Eccrine sweat gland cells': '0.023', 'Adipocytes (Skin)': '-0.118', 'Mitotic cells (Skin)': '0.259', 'Parietal cells': '-0.661', 'Chief cells': '-0.441', 'Gastric mucous cells': '-0.578', 'Gastric enteroendocrine cells': '-0.409', 'Mitotic cells (Stomach)': '-0.171', 'Parafollicular cells': '0.082', 'Thyroid glandular cells': '0.365', 'Mitotic cells (Thyroid)': '0.038', 'Adrenal cortex cells': '0.482', 'Adrenal medulla cells': '0.022', 'Mitotic cells (Adrenal gland)': '0.325', 'Minor salivary glandular cells': '0.348', 'Minor salivary gland ductal cells': '-0.142', 'Minor salivary gland basal cells': '0.545', 'Mitotic cells (Minor salivary gland)': '0.610', 'Adipocytes (Minor salivary gland)': '0.279', 'Somatotropes': '0.129', 'Lactotropes': '-0.039', 'Gonadotropes': '-0.085', 'Corticotropes': '-0.123', 'Thyrotropes': '0.102', 'Undifferentiated cells (Pituitary gland)': '0.149', 'Mitotic cells (Spleen)': '-0.032', 'Platelets': '-0.281', 'Erythrocytes': '-0.079', 'Hematopoietic stem cells': '-0.266', 'B-cells (Spleen)': '0.240', 'NK-cells (Spleen)': '0.269', 'Amygdala excitatory': '53.7', 'Cerebellar inhibitory': '54.8', 'Cge interneuron': '63.2', 'Deep-layer corticothalamic and 6b': '55.3', 'Deep-layer intratelencephalic': '54.2', 'Deep-layer near-projecting': '62.0', 'Eccentric medium spiny neuron': '66.5', 'Hippocampal ca1-3': '60.5', 'Hippocampal ca4': '66.5', 'Hippocampal dentate gyrus': '77.8', 'Lamp5-lhx6 and chandelier': '59.0', 'Lower rhombic lip': '65.1', 'Mammillary body': '77.0', 'Medium spiny neuron': '59.9', 'Mge interneuron': '55.7', 'Midbrain-derived inhibitory': '67.7', 'Miscellaneous': '59.6', 'Splatter': '60.8', 'Thalamic excitatory': '62.5', 'Upper rhombic lip': '76.0', 'Upper-layer intratelencephalic': '60.9', 'Astrocyte': '31.2', 'Bergmann glia': '38.9', 'Central nervous system macrophage': '53.0', 'Choroid plexus epithelial cell': '42.2', 'Committed oligodendrocyte precursor': '52.5', 'Ependymal cell': '34.3', 'Oligodendrocyte': '81.9', 'Oligodendrocyte precursor cell': '49.5', 'Endothelial cell': '53.9', 'Pericyte': '54.4', 'Vascular associated smooth muscle cell': '46.7', 'Fibroblast': '48.0', 'Leukocyte': '59.1', 'Basophil': '41.4', 'Eosinophil': '12.3', 'Neutrophil': '25.3', 'Classical monocyte': '52.1', 'Non-classical monocyte': '57.0', 'Intermediate monocyte': '85.2', 'T-reg': '75.2', 'GdT-cell': '13.1', 'MAIT T-cell': '78.8', 'Memory CD4 T-cell': '19.8', 'Naive CD4 T-cell': '67.1', 'Memory CD8 T-cell': '19.2', 'Naive CD8 T-cell': '56.8', 'Memory B-cell': '14.6', 'Naive B-cell': '63.8', 'Plasmacytoid DC': '62.2', 'Myeloid DC': '74.9', 'NK-cell': '43.1', 'Total PBMC': '68.8', 'Vd2 gdTCR': '64.3', 'Memory CD4 T-cell TFH': '47.8', 'Memory CD4 T-cell Th2': '69.0', 'Memory CD4 T-cell Th17': '63.4', 'Memory CD4 T-cell Th1\\/Th17': '75.5', 'Non-Vd2 gdTCR': '61.6', 'Memory CD4 T-cell Th1': '55.4', 'Terminal effector memory CD4 T-cell': '78.0', 'Central memory CD8 T-cell': '76.5', 'Effector memory CD8 T-cell': '61.4', 'Terminal effector memory CD8 T-cell': '59.4', 'Switched memory B-cell': '51.1', 'Plasmablast': '136.6', 'Non-switched memory B-cell': '52.2', 'Exhausted memory B-cell': '60.4', 'Progenitor cell': '71.8', 'Memory T-reg': '40.3', 'Naive CD4 T-cell activated': '89.0', 'Naive CD8 T-cell activated': '72.6', 'Naive T-reg': '66.0'}
4D10, 4D18, 4WSN, 6A73, 6R6H, 6R7F, 6R7H, 6R7I, 6R7N, 8H38, 8H3A, 8H3F
{'Adipose Tissue': 26.193949418604653, 'Adrenal Gland': 18.817763565891475, 'Bladder': 26.31095238095238, 'Blood': 9.437903864370291, 'Blood Vessel': 32.61502996254682, 'Brain': 13.223627554882665, 'Breast': 25.19100217864924, 'Cervix Uteri': 31.95157894736842, 'Colon': 23.530193838254178, 'Esophagus': 21.99425743944637, 'Fallopian Tube': 29.926666666666662, 'Heart': 11.17275098722416, 'Kidney': 11.378752808988764, 'Liver': 8.497862831858408, 'Lung': 22.343062283737027, 'Muscle': 25.711270236612705, 'Nerve': 30.558772213247178, 'Ovary': 33.775333333333336, 'Pancreas': 9.181603658536584, 'Pituitary': 20.527314487632506, 'Prostate': 20.463220408163263, 'Salivary Gland': 15.256993827160493, 'Skin': 25.447635157545605, 'Small Intestine': 15.08979679144385, 'Spleen': 12.28451867219917, 'Stomach': 16.406217270194986, 'Testis': 20.134473684210526, 'Thyroid': 21.40346401225115, 'Uterus': 30.99105633802817, 'Vagina': 26.5874358974359}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
85.001603
0.363883
1,796
O60260
P61758
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
VBP1
MAAVKDSCGKGEMATGNGRRLHLGIPEAVFVEDVDSFMKQPGNETADTVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTNSMETRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLSTATKNLDSLEEDLDFLRDQFTTTEVNMARVYNWDVKRRNKDDSTKNKA
Homo sapiens
Cytoplasm, Nucleus
Low tissue specificity
{'Ciliated cells': '32.2', 'Basal respiratory cells': '84.4', 'Club cells': '37.4', 'Ionocytes': '43.1', 'Mucus glandular cells': '20.1', 'Serous glandular cells': '22.9', 'Gastric mucus-secreting cells': '27.1', 'Proximal enterocytes': '28.7', 'Paneth cells': '47.6', 'Distal enterocytes': '34.1', 'Intestinal goblet cells': '33.0', 'Exocrine glandular cells': '-0.636', 'Basal prostatic cells': '55.3', 'Prostatic glandular cells': '35.0', 'Breast glandular cells': '0.048', 'Breast myoepithelial cells': '0.031', 'Glandular and luminal cells': '31.3', 'Secretory cells': '46.5', 'Basal keratinocytes': '53.0', 'Suprabasal keratinocytes': '52.3', 'Basal squamous epithelial cells': '27.0', 'Squamous epithelial cells': '38.8', 'Alveolar cells type 1': '0.087', 'Alveolar cells type 2': '-0.147', 'Salivary duct cells': '23.3', 'Ductal cells': '0.633', 'Hepatocytes': '0.528', 'Cholangiocytes': '32.4', 'Proximal tubular cells': '0.126', 'Distal tubular cells': '172.1', 'Collecting duct cells': '42.8', 'Mesothelial cells': '0.156', 'Sertoli cells': '0.607', 'Granulosa cells': '41.4', 'Enteroendocrine cells': '32.8', 'Pancreatic endocrine cells': '69.6', 'Leydig cells': '0.690', 'Excitatory neurons': '12.3', 'Inhibitory neurons': '13.6', 'Cone photoreceptor cells': '54.4', 'Rod photoreceptor cells': '34.8', 'Bipolar cells': '41.7', 'Horizontal cells': '26.4', 'Astrocytes': '11.5', 'Oligodendrocyte precursor cells': '6.1', 'Oligodendrocytes': '19.8', 'Microglial cells': '6.3', 'Muller glia cells': '61.6', 'Schwann cells': '0.147', 'Spermatogonia': '0.614', 'Spermatocytes': '0.322', 'Early spermatids': '-0.437', 'Late spermatids': '-0.699', 'Oocytes': '88.2', 'Cytotrophoblasts': '78.6', 'Syncytiotrophoblasts': '67.0', 'Extravillous trophoblasts': '106.2', 'Endothelial cells': '40.1', 'Lymphatic endothelial cells': '40.9', 'Cardiomyocytes': '0.713', 'Skeletal myocytes': '0.258', 'Smooth muscle cells': '42.7', 'Adipocytes': '37.4', 'Melanocytes': '0.101', 'Fibroblasts': '48.7', 'Peritubular cells': '0.507', 'Endometrial stromal cells': '40.1', 'Ovarian stromal cells': '53.2', 'Undifferentiated cells': '58.2', 'T-cells': '53.7', 'B-cells': '45.7', 'Plasma cells': '61.4', 'Nk-cells': '44.8', 'Granulocytes': '50.1', 'Monocytes': '28.6', 'Macrophages': '36.4', 'Hofbauer cells': '66.8', 'Kupffer cells': '27.5', 'Dendritic cells': '59.1', 'Langerhans cells': '0.163', 'Erythroid cells': '-0.044', 'Adipocytes (Subcutaneous)': '0.080', 'Adipocytes (Visceral)': '-0.111', 'Breast glandular cells (progenitors)': '-0.087', 'Adipocytes (Breast)': '0.091', 'Colon enterocytes': '-0.208', 'Colon enteroendocrine cells': '0.416', 'Enteric glia cells': '0.246', 'Mitotic cells (Colon)': '-0.110', 'Mitotic cells (Heart)': '0.461', 'Podocytes': '0.218', 'Ascending Loop of Henle cells': '0.350', 'Intercalated cells': '0.170', 'Cholangiocyte': '0.356', 'NK-cells (Liver)': '-0.351', 'Respiratory ciliated cells': '-0.005', 'Mitotic cells (Lung)': '0.076', 'NK-cells (Lung)': '0.062', 'B-cells (Lung)': '-0.135', 'Alpha cells': '0.396', 'Beta cells': '0.228', 'Prostate glandular cells': '-0.032', 'Prostate basal glandular cells': '-0.062', 'Urothelial cells': '-0.048', 'Keratinocyte (other)': '0.018', 'Keratinocyte (granular)': '-0.290', 'Hair cortex cells': '0.115', 'Inner root sheath cells': '0.238', 'Outer root sheath cells': '0.388', 'Sebaceous gland cells': '0.142', 'Eccrine sweat gland cells': '0.180', 'Adipocytes (Skin)': '-0.015', 'Mitotic cells (Skin)': '0.349', 'Parietal cells': '-0.667', 'Chief cells': '-0.535', 'Gastric mucous cells': '-0.443', 'Gastric enteroendocrine cells': '-0.428', 'Mitotic cells (Stomach)': '0.063', 'Parafollicular cells': '0.136', 'Thyroid glandular cells': '0.488', 'Mitotic cells (Thyroid)': '0.032', 'Adrenal cortex cells': '0.397', 'Adrenal medulla cells': '0.090', 'Mitotic cells (Adrenal gland)': '0.323', 'Minor salivary glandular cells': '0.166', 'Minor salivary gland ductal cells': '-0.210', 'Minor salivary gland basal cells': '0.554', 'Mitotic cells (Minor salivary gland)': '0.619', 'Adipocytes (Minor salivary gland)': '0.259', 'Somatotropes': '0.033', 'Lactotropes': '0.018', 'Gonadotropes': '-0.102', 'Corticotropes': '0.010', 'Thyrotropes': '0.189', 'Undifferentiated cells (Pituitary gland)': '0.195', 'Mitotic cells (Spleen)': '0.121', 'Platelets': '-0.084', 'Erythrocytes': '0.050', 'Hematopoietic stem cells': '-0.093', 'B-cells (Spleen)': '0.115', 'NK-cells (Spleen)': '0.184', 'Amygdala excitatory': '16.8', 'Cerebellar inhibitory': '28.3', 'Cge interneuron': '30.1', 'Deep-layer corticothalamic and 6b': '18.6', 'Deep-layer intratelencephalic': '19.4', 'Deep-layer near-projecting': '19.5', 'Eccentric medium spiny neuron': '17.3', 'Hippocampal ca1-3': '19.9', 'Hippocampal ca4': '33.6', 'Hippocampal dentate gyrus': '24.7', 'Lamp5-lhx6 and chandelier': '28.3', 'Lower rhombic lip': '23.5', 'Mammillary body': '24.3', 'Medium spiny neuron': '14.9', 'Mge interneuron': '22.8', 'Midbrain-derived inhibitory': '23.9', 'Miscellaneous': '20.6', 'Splatter': '27.3', 'Thalamic excitatory': '26.3', 'Upper rhombic lip': '27.1', 'Upper-layer intratelencephalic': '16.3', 'Astrocyte': '13.5', 'Bergmann glia': '24.2', 'Central nervous system macrophage': '14.6', 'Choroid plexus epithelial cell': '20.5', 'Committed oligodendrocyte precursor': '21.9', 'Ependymal cell': '19.0', 'Oligodendrocyte': '33.4', 'Oligodendrocyte precursor cell': '27.3', 'Endothelial cell': '18.0', 'Pericyte': '20.8', 'Vascular associated smooth muscle cell': '23.7', 'Fibroblast': '15.7', 'Leukocyte': '17.9', 'Basophil': '66.8', 'Eosinophil': '75.9', 'Neutrophil': '165.0', 'Classical monocyte': '41.6', 'Non-classical monocyte': '53.8', 'Intermediate monocyte': '88.7', 'T-reg': '111.0', 'GdT-cell': '26.3', 'MAIT T-cell': '115.1', 'Memory CD4 T-cell': '30.6', 'Naive CD4 T-cell': '76.9', 'Memory CD8 T-cell': '31.7', 'Naive CD8 T-cell': '64.1', 'Memory B-cell': '28.6', 'Naive B-cell': '45.5', 'Plasmacytoid DC': '186.6', 'Myeloid DC': '154.3', 'NK-cell': '54.6', 'Total PBMC': '103.3', 'Vd2 gdTCR': '114.0', 'Memory CD4 T-cell Th1\\/Th17': '71.3', 'Memory CD4 T-cell Th17': '72.8', 'Memory CD4 T-cell Th2': '76.3', 'Non-Vd2 gdTCR': '113.7', 'Memory CD4 T-cell Th1': '53.9', 'Memory CD4 T-cell TFH': '62.2', 'Terminal effector memory CD4 T-cell': '101.8', 'Central memory CD8 T-cell': '126.2', 'Effector memory CD8 T-cell': '125.7', 'Terminal effector memory CD8 T-cell': '120.2', 'Non-switched memory B-cell': '89.7', 'Plasmablast': '180.8', 'Switched memory B-cell': '94.5', 'Exhausted memory B-cell': '82.4', 'Progenitor cell': '106.7', 'Memory T-reg': '53.7', 'Naive CD4 T-cell activated': '105.9', 'Naive CD8 T-cell activated': '95.3', 'Naive T-reg': '83.8'}
6NR8, 6NR9, 6NRB, 6NRC, 6NRD, 7WU7
{'Adipose Tissue': 34.65422674418605, 'Adrenal Gland': 30.70691472868217, 'Bladder': 37.97142857142857, 'Blood': 27.27375306781485, 'Blood Vessel': 39.84371535580525, 'Brain': 52.663660484481454, 'Breast': 35.1579302832244, 'Cervix Uteri': 40.23315789473685, 'Colon': 35.24512195121952, 'Esophagus': 34.94085813148789, 'Fallopian Tube': 39.67444444444445, 'Heart': 30.866737514518, 'Kidney': 27.203348314606743, 'Liver': 13.338022123893806, 'Lung': 39.23657439446367, 'Muscle': 56.7375591531756, 'Nerve': 48.38063004846527, 'Ovary': 40.592333333333336, 'Pancreas': 11.836021341463416, 'Pituitary': 51.117173144876325, 'Prostate': 36.18440816326531, 'Salivary Gland': 23.64956790123457, 'Skin': 34.49996904367054, 'Small Intestine': 28.588449197860964, 'Spleen': 30.565352697095435, 'Stomach': 26.188910863509747, 'Testis': 21.341335180055403, 'Thyroid': 38.15738131699847, 'Uterus': 40.85823943661972, 'Vagina': 35.983782051282056}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
86.122284
0.476396
2,750
O60260
P61962
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
DCAF7
MSLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYNNKVQLVGLDEESSEFICRNTFDHPYPTTKLMWIPDTKGVYPDLLATSGDYLRVWRVGETETRLECLLNNNKNSDFCAPLTSFDWNEVDPYLLGTSSIDTTCTIWGLETGQVLGRVNLVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPQHHPLLRLCWNKQDPNYLATMAMDGMEVVILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTAEGEINNVQWASTQPDWIAICYNNCLEILRV
Homo sapiens
Cytoplasm, Nucleus
Low tissue specificity
{'Ciliated cells': '33.7', 'Basal respiratory cells': '48.2', 'Club cells': '53.1', 'Ionocytes': '42.3', 'Mucus glandular cells': '44.1', 'Serous glandular cells': '39.9', 'Gastric mucus-secreting cells': '26.5', 'Proximal enterocytes': '64.5', 'Paneth cells': '42.8', 'Distal enterocytes': '49.1', 'Intestinal goblet cells': '49.9', 'Exocrine glandular cells': '-0.665', 'Basal prostatic cells': '44.7', 'Prostatic glandular cells': '57.3', 'Breast glandular cells': '0.492', 'Breast myoepithelial cells': '0.438', 'Glandular and luminal cells': '30.4', 'Secretory cells': '33.0', 'Basal keratinocytes': '33.6', 'Suprabasal keratinocytes': '33.4', 'Basal squamous epithelial cells': '45.9', 'Squamous epithelial cells': '51.3', 'Alveolar cells type 1': '0.135', 'Alveolar cells type 2': '-0.114', 'Salivary duct cells': '49.9', 'Ductal cells': '0.676', 'Hepatocytes': '0.564', 'Cholangiocytes': '36.2', 'Proximal tubular cells': '0.289', 'Distal tubular cells': '15.4', 'Collecting duct cells': '56.4', 'Mesothelial cells': '0.360', 'Sertoli cells': '0.105', 'Granulosa cells': '69.2', 'Enteroendocrine cells': '60.6', 'Pancreatic endocrine cells': '35.7', 'Leydig cells': '0.002', 'Excitatory neurons': '40.9', 'Inhibitory neurons': '39.4', 'Cone photoreceptor cells': '71.4', 'Rod photoreceptor cells': '53.9', 'Bipolar cells': '48.6', 'Horizontal cells': '46.6', 'Astrocytes': '28.8', 'Oligodendrocyte precursor cells': '34.0', 'Oligodendrocytes': '37.8', 'Microglial cells': '41.2', 'Muller glia cells': '48.3', 'Schwann cells': '0.124', 'Spermatogonia': '0.398', 'Spermatocytes': '0.551', 'Early spermatids': '0.475', 'Late spermatids': '0.084', 'Oocytes': '54.4', 'Cytotrophoblasts': '52.6', 'Syncytiotrophoblasts': '20.2', 'Extravillous trophoblasts': '49.9', 'Endothelial cells': '41.3', 'Lymphatic endothelial cells': '34.8', 'Cardiomyocytes': '0.611', 'Skeletal myocytes': '-0.171', 'Smooth muscle cells': '35.3', 'Adipocytes': '27.7', 'Melanocytes': '0.214', 'Fibroblasts': '32.5', 'Peritubular cells': '0.015', 'Endometrial stromal cells': '37.7', 'Ovarian stromal cells': '27.8', 'Undifferentiated cells': '60.6', 'T-cells': '51.2', 'B-cells': '54.3', 'Plasma cells': '46.8', 'Nk-cells': '61.1', 'Granulocytes': '49.1', 'Monocytes': '55.7', 'Macrophages': '59.4', 'Hofbauer cells': '56.2', 'Kupffer cells': '60.5', 'Dendritic cells': '52.8', 'Langerhans cells': '0.241', 'Erythroid cells': '-0.070', 'Adipocytes (Subcutaneous)': '-0.352', 'Adipocytes (Visceral)': '-0.351', 'Breast glandular cells (progenitors)': '0.389', 'Adipocytes (Breast)': '-0.437', 'Colon enterocytes': '0.092', 'Colon enteroendocrine cells': '0.168', 'Enteric glia cells': '-0.230', 'Mitotic cells (Colon)': '0.149', 'Mitotic cells (Heart)': '0.530', 'Podocytes': '-0.099', 'Ascending Loop of Henle cells': '0.453', 'Intercalated cells': '0.028', 'Cholangiocyte': '0.300', 'NK-cells (Liver)': '-0.335', 'Respiratory ciliated cells': '-0.016', 'Mitotic cells (Lung)': '0.231', 'NK-cells (Lung)': '0.199', 'B-cells (Lung)': '-0.020', 'Alpha cells': '0.452', 'Beta cells': '0.281', 'Prostate glandular cells': '0.131', 'Prostate basal glandular cells': '0.396', 'Urothelial cells': '0.208', 'Keratinocyte (other)': '0.104', 'Keratinocyte (granular)': '-0.283', 'Hair cortex cells': '0.166', 'Inner root sheath cells': '0.218', 'Outer root sheath cells': '0.381', 'Sebaceous gland cells': '0.193', 'Eccrine sweat gland cells': '0.193', 'Adipocytes (Skin)': '0.088', 'Mitotic cells (Skin)': '0.471', 'Parietal cells': '-0.373', 'Chief cells': '-0.376', 'Gastric mucous cells': '-0.069', 'Gastric enteroendocrine cells': '-0.219', 'Mitotic cells (Stomach)': '0.332', 'Parafollicular cells': '0.092', 'Thyroid glandular cells': '0.455', 'Mitotic cells (Thyroid)': '0.082', 'Adrenal cortex cells': '0.560', 'Adrenal medulla cells': '0.091', 'Mitotic cells (Adrenal gland)': '0.421', 'Minor salivary glandular cells': '0.639', 'Minor salivary gland ductal cells': '0.334', 'Minor salivary gland basal cells': '0.213', 'Mitotic cells (Minor salivary gland)': '0.252', 'Adipocytes (Minor salivary gland)': '0.127', 'Somatotropes': '-0.155', 'Lactotropes': '-0.017', 'Gonadotropes': '0.040', 'Corticotropes': '0.086', 'Thyrotropes': '0.247', 'Undifferentiated cells (Pituitary gland)': '0.248', 'Mitotic cells (Spleen)': '-0.008', 'Platelets': '-0.013', 'Erythrocytes': '-0.191', 'Hematopoietic stem cells': '-0.123', 'B-cells (Spleen)': '0.321', 'NK-cells (Spleen)': '0.266', 'Amygdala excitatory': '70.9', 'Cerebellar inhibitory': '47.9', 'Cge interneuron': '66.7', 'Deep-layer corticothalamic and 6b': '68.1', 'Deep-layer intratelencephalic': '69.5', 'Deep-layer near-projecting': '67.5', 'Eccentric medium spiny neuron': '69.3', 'Hippocampal ca1-3': '68.0', 'Hippocampal ca4': '60.1', 'Hippocampal dentate gyrus': '65.4', 'Lamp5-lhx6 and chandelier': '64.6', 'Lower rhombic lip': '43.1', 'Mammillary body': '57.6', 'Medium spiny neuron': '69.8', 'Mge interneuron': '66.4', 'Midbrain-derived inhibitory': '63.9', 'Miscellaneous': '68.4', 'Splatter': '57.5', 'Thalamic excitatory': '53.8', 'Upper rhombic lip': '63.2', 'Upper-layer intratelencephalic': '69.0', 'Astrocyte': '57.0', 'Bergmann glia': '59.3', 'Central nervous system macrophage': '116.9', 'Choroid plexus epithelial cell': '67.8', 'Committed oligodendrocyte precursor': '80.4', 'Ependymal cell': '42.5', 'Oligodendrocyte': '71.4', 'Oligodendrocyte precursor cell': '67.5', 'Endothelial cell': '78.8', 'Pericyte': '69.2', 'Vascular associated smooth muscle cell': '78.4', 'Fibroblast': '66.0', 'Leukocyte': '122.9', 'Basophil': '94.5', 'Eosinophil': '25.6', 'Neutrophil': '47.3', 'Classical monocyte': '29.5', 'Non-classical monocyte': '71.2', 'Intermediate monocyte': '125.9', 'T-reg': '66.3', 'GdT-cell': '13.6', 'MAIT T-cell': '85.3', 'Memory CD4 T-cell': '9.6', 'Naive CD4 T-cell': '34.9', 'Memory CD8 T-cell': '10.1', 'Naive CD8 T-cell': '34.5', 'Memory B-cell': '12.3', 'Naive B-cell': '33.4', 'Plasmacytoid DC': '109.4', 'Myeloid DC': '109.6', 'NK-cell': '63.1', 'Total PBMC': '76.5', 'Vd2 gdTCR': '95.2', 'Memory CD4 T-cell Th1\\/Th17': '32.8', 'Memory CD4 T-cell Th17': '36.3', 'Memory CD4 T-cell Th2': '37.5', 'Non-Vd2 gdTCR': '111.9', 'Memory CD4 T-cell Th1': '35.6', 'Memory CD4 T-cell TFH': '43.1', 'Terminal effector memory CD4 T-cell': '100.7', 'Central memory CD8 T-cell': '89.6', 'Effector memory CD8 T-cell': '86.5', 'Terminal effector memory CD8 T-cell': '126.8', 'Non-switched memory B-cell': '73.1', 'Plasmablast': '82.1', 'Switched memory B-cell': '90.7', 'Exhausted memory B-cell': '78.4', 'Progenitor cell': '123.0', 'Memory T-reg': '45.2', 'Naive CD4 T-cell activated': '80.7', 'Naive CD8 T-cell activated': '101.7', 'Naive T-reg': '41.3'}
null
{'Adipose Tissue': 25.33996926910299, 'Adrenal Gland': 22.02387984496124, 'Bladder': 33.93714285714285, 'Blood': 24.89881851453175, 'Blood Vessel': 28.032262172284643, 'Brain': 22.228756245268738, 'Breast': 26.684063180827888, 'Cervix Uteri': 34.47736842105263, 'Colon': 27.811227214377407, 'Esophagus': 27.65825605536332, 'Fallopian Tube': 32.142222222222216, 'Heart': 12.257488966318236, 'Kidney': 18.834101123595502, 'Liver': 10.259433628318584, 'Lung': 38.4673875432526, 'Muscle': 10.85612702366127, 'Nerve': 38.89562197092084, 'Ovary': 30.82188888888889, 'Pancreas': 11.536634146341465, 'Pituitary': 27.677067137809185, 'Prostate': 31.45004081632653, 'Salivary Gland': 28.8233950617284, 'Skin': 28.158390270867883, 'Small Intestine': 35.023101604278075, 'Spleen': 36.01788381742738, 'Stomach': 22.24789972144847, 'Testis': 40.6386703601108, 'Thyroid': 35.08623277182236, 'Uterus': 37.449436619718306, 'Vagina': 29.104807692307695}
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[31.28, 37.71, 40.1, 45.06, 52.02, 57.29, 62.8, 76.68, 88.77, 94.61, 96.83, 96.75, 97.93, 97.99, 97.58, 96.47, 96.82, 97.5, 97.44, 94.44, 96.92, 97.86, 98.38, 98.09, 97.17, 95.58, 92.68, 88.36, 91.54, 92.64, 93.45, 95.84, 97.37, 98.36, 98.47, 98.52, 98.23, 97.68, 96.53, 95.58, 89.6, 89.74, 90.81, 94.92, 97.45, 97.54, 98.14, 97.57, 97.74, 97.61, 96.41, 96.29, 94.32, 88.01, 91.15, 92.96, 92.39, 94.57, 96.92, 96.07, 96.01, 94.57, 95.26, 96.6, 97.08, 96.81, 97.41, 93.2, 94.83, 97.01, 97.68, 97.27, 98.44, 98.27, 98.43, 97.9, 96.42, 95.21, 93.2, 91.23, 91.14, 89.71, 89.51, 89.59, 90.18, 93.26, 95.46, 97.72, 98.25, 98.47, 97.59, 95.19, 93.66, 95.38, 96.93, 97.03, 97.12, 96.83, 94.69, 95.03, 91.8, 86.79, 86.79, 91.52, 95.88, 94.77, 95.01, 92.8, 92.67, 94.23, 93.59, 89.57, 82.38, 78.54, 70.16, 68.96, 72.16, 67.53, 72.17, 82.04, 89.97, 93.92, 97.38, 98.16, 98.45, 98.7, 98.59, 97.86, 96.79, 94.06, 94.16, 93.52, 93.31, 93.58, 95.67, 97.76, 97.9, 98.49, 98.46, 97.52, 97.0, 95.7, 97.09, 96.83, 97.77, 97.19, 97.35, 96.82, 94.47, 92.35, 85.69, 68.77, 60.05, 56.87, 57.91, 56.39, 55.09, 57.25, 57.25, 69.43, 76.33, 83.09, 87.04, 90.42, 92.25, 94.68, 94.32, 94.75, 94.45, 95.1, 95.51, 97.03, 97.69, 95.78, 98.17, 98.4, 98.73, 98.7, 98.77, 98.75, 98.55, 97.95, 96.58, 93.12, 88.89, 83.3, 86.72, 86.21, 89.47, 92.49, 95.65, 97.52, 98.23, 98.69, 98.75, 98.45, 98.63, 98.06, 98.19, 98.31, 98.56, 97.79, 96.7, 96.73, 94.73, 93.94, 91.8, 91.05, 88.96, 86.47, 86.02, 91.84, 94.16, 95.7, 96.23, 98.11, 97.67, 97.18, 95.13, 95.61, 95.66, 97.88, 98.67, 98.7, 98.31, 98.46, 98.55, 98.37, 97.93, 97.55, 93.2, 95.43, 96.31, 95.97, 95.66, 97.33, 98.01, 98.56, 98.66, 97.99, 98.2, 97.58, 96.67, 97.73, 97.92, 97.3, 98.38, 97.76, 98.12, 97.83, 96.2, 95.28, 93.86, 93.93, 92.32, 92.08, 93.79, 96.39, 96.63, 96.65, 96.84, 98.18, 96.69, 97.28, 98.31, 98.18, 98.44, 98.02, 98.6, 97.89, 97.57, 98.5, 98.41, 98.54, 98.05, 95.97, 95.2, 97.2, 96.87, 97.45, 98.25, 98.58, 98.66, 98.75, 98.57, 98.72, 98.55, 98.54, 98.54, 98.54, 98.51, 98.58, 98.51, 98.51, 97.62, 96.57, 95.66, 92.78, 93.03, 88.43, 91.97, 90.57, 93.73, 90.74, 95.32, 97.46, 97.23, 97.16, 97.65, 97.9, 98.16, 97.87, 97.53, 98.0, 98.36, 98.56, 96.84, 97.53, 98.42, 98.3, 98.21, 97.03, 93.64, 94.14, 94.59, 95.68, 95.9, 97.36, 98.31, 98.49, 98.54, 98.07, 98.15, 97.46, 97.84, 98.15, 98.31, 97.86, 97.85, 97.19, 95.79, 92.04]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
93.210205
0.287719
2,210
O60260
P62191
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PSMC1
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
Homo sapiens
Cytoplasm, Nucleus, Membrane
Tissue enhanced (skeletal)
{'Ciliated cells': '67.3', 'Basal respiratory cells': '137.9', 'Club cells': '78.8', 'Ionocytes': '112.3', 'Mucus glandular cells': '63.6', 'Serous glandular cells': '57.9', 'Gastric mucus-secreting cells': '30.1', 'Proximal enterocytes': '104.6', 'Paneth cells': '86.0', 'Distal enterocytes': '94.3', 'Intestinal goblet cells': '63.0', 'Exocrine glandular cells': '-0.568', 'Basal prostatic cells': '60.4', 'Prostatic glandular cells': '48.9', 'Breast glandular cells': '-0.168', 'Breast myoepithelial cells': '-0.194', 'Glandular and luminal cells': '50.5', 'Secretory cells': '86.1', 'Basal keratinocytes': '86.5', 'Suprabasal keratinocytes': '96.0', 'Basal squamous epithelial cells': '29.7', 'Squamous epithelial cells': '44.1', 'Alveolar cells type 1': '0.026', 'Alveolar cells type 2': '0.404', 'Salivary duct cells': '51.4', 'Ductal cells': '0.446', 'Hepatocytes': '0.625', 'Cholangiocytes': '76.3', 'Proximal tubular cells': '0.307', 'Distal tubular cells': '110.6', 'Collecting duct cells': '60.3', 'Mesothelial cells': '-0.056', 'Sertoli cells': '-0.252', 'Granulosa cells': '65.0', 'Enteroendocrine cells': '53.0', 'Pancreatic endocrine cells': '222.4', 'Leydig cells': '-0.291', 'Excitatory neurons': '20.3', 'Inhibitory neurons': '20.3', 'Cone photoreceptor cells': '54.4', 'Rod photoreceptor cells': '47.8', 'Bipolar cells': '49.5', 'Horizontal cells': '44.7', 'Astrocytes': '10.8', 'Oligodendrocyte precursor cells': '9.9', 'Oligodendrocytes': '20.8', 'Microglial cells': '13.4', 'Muller glia cells': '80.5', 'Schwann cells': '0.043', 'Spermatogonia': '-0.025', 'Spermatocytes': '0.266', 'Early spermatids': '0.728', 'Late spermatids': '0.519', 'Oocytes': '190.4', 'Cytotrophoblasts': '293.6', 'Syncytiotrophoblasts': '484.7', 'Extravillous trophoblasts': '173.3', 'Endothelial cells': '75.3', 'Lymphatic endothelial cells': '74.7', 'Cardiomyocytes': '0.708', 'Skeletal myocytes': '-0.296', 'Smooth muscle cells': '68.8', 'Adipocytes': '52.9', 'Melanocytes': '0.305', 'Fibroblasts': '70.7', 'Peritubular cells': '-0.233', 'Endometrial stromal cells': '41.8', 'Ovarian stromal cells': '75.1', 'Undifferentiated cells': '81.7', 'T-cells': '47.5', 'B-cells': '37.7', 'Plasma cells': '69.1', 'Nk-cells': '57.0', 'Granulocytes': '94.5', 'Monocytes': '70.5', 'Macrophages': '64.9', 'Hofbauer cells': '127.3', 'Kupffer cells': '79.6', 'Dendritic cells': '40.1', 'Langerhans cells': '0.298', 'Erythroid cells': '-0.102', 'Adipocytes (Subcutaneous)': '0.255', 'Adipocytes (Visceral)': '0.282', 'Breast glandular cells (progenitors)': '-0.186', 'Adipocytes (Breast)': '0.370', 'Colon enterocytes': '-0.090', 'Colon enteroendocrine cells': '0.121', 'Enteric glia cells': '-0.459', 'Mitotic cells (Colon)': '-0.075', 'Mitotic cells (Heart)': '0.437', 'Podocytes': '-0.058', 'Ascending Loop of Henle cells': '0.304', 'Intercalated cells': '0.004', 'Cholangiocyte': '0.320', 'NK-cells (Liver)': '-0.369', 'Respiratory ciliated cells': '-0.132', 'Mitotic cells (Lung)': '0.169', 'NK-cells (Lung)': '-0.311', 'B-cells (Lung)': '-0.317', 'Alpha cells': '0.265', 'Beta cells': '0.090', 'Prostate glandular cells': '-0.066', 'Prostate basal glandular cells': '0.081', 'Urothelial cells': '-0.095', 'Keratinocyte (other)': '0.265', 'Keratinocyte (granular)': '0.087', 'Hair cortex cells': '0.159', 'Inner root sheath cells': '0.219', 'Outer root sheath cells': '0.123', 'Sebaceous gland cells': '0.073', 'Eccrine sweat gland cells': '-0.128', 'Adipocytes (Skin)': '-0.102', 'Mitotic cells (Skin)': '0.361', 'Parietal cells': '-0.544', 'Chief cells': '-0.472', 'Gastric mucous cells': '-0.278', 'Gastric enteroendocrine cells': '-0.452', 'Mitotic cells (Stomach)': '0.162', 'Parafollicular cells': '0.073', 'Thyroid glandular cells': '0.361', 'Mitotic cells (Thyroid)': '-0.036', 'Adrenal cortex cells': '0.664', 'Adrenal medulla cells': '0.063', 'Mitotic cells (Adrenal gland)': '0.478', 'Minor salivary glandular cells': '0.334', 'Minor salivary gland ductal cells': '-0.272', 'Minor salivary gland basal cells': '0.497', 'Mitotic cells (Minor salivary gland)': '0.620', 'Adipocytes (Minor salivary gland)': '0.247', 'Somatotropes': '-0.040', 'Lactotropes': '-0.059', 'Gonadotropes': '0.031', 'Corticotropes': '-0.170', 'Thyrotropes': '0.046', 'Undifferentiated cells (Pituitary gland)': '0.247', 'Mitotic cells (Spleen)': '0.064', 'Platelets': '0.052', 'Erythrocytes': '-0.114', 'Hematopoietic stem cells': '0.067', 'B-cells (Spleen)': '0.001', 'NK-cells (Spleen)': '-0.104', 'Amygdala excitatory': '17.6', 'Cerebellar inhibitory': '20.6', 'Cge interneuron': '18.0', 'Deep-layer corticothalamic and 6b': '18.1', 'Deep-layer intratelencephalic': '19.2', 'Deep-layer near-projecting': '20.0', 'Eccentric medium spiny neuron': '17.4', 'Hippocampal ca1-3': '15.8', 'Hippocampal ca4': '17.9', 'Hippocampal dentate gyrus': '22.3', 'Lamp5-lhx6 and chandelier': '19.7', 'Lower rhombic lip': '19.0', 'Mammillary body': '18.1', 'Medium spiny neuron': '15.5', 'Mge interneuron': '18.4', 'Midbrain-derived inhibitory': '18.5', 'Miscellaneous': '16.8', 'Splatter': '17.8', 'Thalamic excitatory': '15.7', 'Upper rhombic lip': '24.5', 'Upper-layer intratelencephalic': '18.3', 'Astrocyte': '15.1', 'Bergmann glia': '20.0', 'Central nervous system macrophage': '20.2', 'Choroid plexus epithelial cell': '12.1', 'Committed oligodendrocyte precursor': '19.5', 'Ependymal cell': '8.9', 'Oligodendrocyte': '23.9', 'Oligodendrocyte precursor cell': '17.1', 'Endothelial cell': '18.2', 'Pericyte': '21.6', 'Vascular associated smooth muscle cell': '16.4', 'Fibroblast': '15.4', 'Leukocyte': '17.5', 'Basophil': '85.6', 'Eosinophil': '160.4', 'Neutrophil': '133.9', 'Classical monocyte': '2.5', 'Non-classical monocyte': '3.6', 'Intermediate monocyte': '112.6', 'T-reg': '88.7', 'GdT-cell': '67.3', 'MAIT T-cell': '85.8', 'Memory CD4 T-cell': '68.7', 'Naive CD4 T-cell': '4.1', 'Memory CD8 T-cell': '69.0', 'Naive CD8 T-cell': '4.3', 'Memory B-cell': '57.9', 'Naive B-cell': '5.4', 'Plasmacytoid DC': '123.0', 'Myeloid DC': '133.9', 'NK-cell': '5.3', 'Total PBMC': '116.8', 'Vd2 gdTCR': '99.2', 'Memory CD4 T-cell TFH': '4.6', 'Memory CD4 T-cell Th2': '5.1', 'Memory CD4 T-cell Th17': '4.4', 'Memory CD4 T-cell Th1\\/Th17': '5.0', 'Non-Vd2 gdTCR': '102.0', 'Memory CD4 T-cell Th1': '4.7', 'Terminal effector memory CD4 T-cell': '113.8', 'Central memory CD8 T-cell': '76.7', 'Effector memory CD8 T-cell': '100.0', 'Terminal effector memory CD8 T-cell': '101.5', 'Switched memory B-cell': '85.2', 'Plasmablast': '163.8', 'Non-switched memory B-cell': '75.4', 'Exhausted memory B-cell': '80.8', 'Progenitor cell': '90.2', 'Memory T-reg': '4.8', 'Naive CD4 T-cell activated': '1.6', 'Naive CD8 T-cell activated': '1.5', 'Naive T-reg': '3.8'}
5GJQ, 5GJR, 5L4G, 5LN3, 5M32, 5T0C, 5T0G, 5T0H, 5T0I, 5T0J, 5VFP, 5VFQ, 5VFR, 5VFS, 5VFT, 5VFU, 5VGZ, 5VHF, 5VHH, 5VHI, 5VHJ, 5VHM, 5VHN, 5VHO, 5VHP, 5VHQ, 5VHR, 5VHS, 6MSB, 6MSD, 6MSG, 6MSH, 6MSJ, 6MSK, 6WJD, 6WJN, 7QXN, 7QXP, 7QXU, 7QXW, 7QXX, 7QY7, 7QYA, 7QYB, 7W37, 7W38, 7W39, 7W3A, 7W3B, 7W3C, 7W3F, 7W3G, 7W3H, 7W3I, 7W3J, 7W3K, 7W3M, 8CVT
{'Adipose Tissue': 61.8201245847176, 'Adrenal Gland': 45.758062015503874, 'Bladder': 61.418571428571425, 'Blood': 45.34963186221744, 'Blood Vessel': 81.64149812734082, 'Brain': 29.17954401968206, 'Breast': 56.91623093681917, 'Cervix Uteri': 55.626842105263165, 'Colon': 53.21473427471117, 'Esophagus': 58.63146297577854, 'Fallopian Tube': 61.44222222222223, 'Heart': 39.765693379790946, 'Kidney': 25.8022808988764, 'Liver': 19.99239557522124, 'Lung': 56.10487889273356, 'Muscle': 137.8609339975093, 'Nerve': 73.11954765751211, 'Ovary': 51.44588888888889, 'Pancreas': 17.376631097560974, 'Pituitary': 30.52340282685512, 'Prostate': 39.45069387755102, 'Salivary Gland': 47.71549382716049, 'Skin': 72.57411829740187, 'Small Intestine': 44.55663101604278, 'Spleen': 41.06867219917012, 'Stomach': 42.10625626740947, 'Testis': 84.90468144044321, 'Thyroid': 51.58309341500766, 'Uterus': 70.05619718309859, 'Vagina': 54.22378205128205}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
77.631955
0.458091
1,808
O60260
P62195
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PSMC5
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
Homo sapiens
Cytoplasm, Nucleus
Low tissue specificity
{'Ciliated cells': '97.7', 'Basal respiratory cells': '203.7', 'Club cells': '139.3', 'Ionocytes': '164.6', 'Mucus glandular cells': '94.9', 'Serous glandular cells': '154.2', 'Gastric mucus-secreting cells': '70.7', 'Proximal enterocytes': '162.0', 'Paneth cells': '97.4', 'Distal enterocytes': '105.8', 'Intestinal goblet cells': '81.4', 'Exocrine glandular cells': '-0.693', 'Basal prostatic cells': '160.2', 'Prostatic glandular cells': '106.9', 'Breast glandular cells': '0.330', 'Breast myoepithelial cells': '-0.086', 'Glandular and luminal cells': '75.7', 'Secretory cells': '136.4', 'Basal keratinocytes': '150.8', 'Suprabasal keratinocytes': '218.5', 'Basal squamous epithelial cells': '70.0', 'Squamous epithelial cells': '96.7', 'Alveolar cells type 1': '-0.119', 'Alveolar cells type 2': '-0.033', 'Salivary duct cells': '104.2', 'Ductal cells': '0.537', 'Hepatocytes': '0.497', 'Cholangiocytes': '99.2', 'Proximal tubular cells': '0.245', 'Distal tubular cells': '199.8', 'Collecting duct cells': '73.9', 'Mesothelial cells': '0.287', 'Sertoli cells': '-0.496', 'Granulosa cells': '61.8', 'Enteroendocrine cells': '90.5', 'Pancreatic endocrine cells': '183.4', 'Leydig cells': '-0.513', 'Excitatory neurons': '7.6', 'Inhibitory neurons': '7.5', 'Cone photoreceptor cells': '103.6', 'Rod photoreceptor cells': '68.1', 'Bipolar cells': '86.5', 'Horizontal cells': '48.5', 'Astrocytes': '8.1', 'Oligodendrocyte precursor cells': '7.1', 'Oligodendrocytes': '9.8', 'Microglial cells': '5.4', 'Muller glia cells': '197.1', 'Schwann cells': '0.150', 'Spermatogonia': '-0.280', 'Spermatocytes': '0.020', 'Early spermatids': '0.726', 'Late spermatids': '0.718', 'Oocytes': '325.0', 'Cytotrophoblasts': '260.6', 'Syncytiotrophoblasts': '406.6', 'Extravillous trophoblasts': '194.9', 'Endothelial cells': '111.7', 'Lymphatic endothelial cells': '71.6', 'Cardiomyocytes': '0.669', 'Skeletal myocytes': '-0.352', 'Smooth muscle cells': '133.8', 'Adipocytes': '93.0', 'Melanocytes': '0.040', 'Fibroblasts': '133.9', 'Peritubular cells': '-0.359', 'Endometrial stromal cells': '71.7', 'Ovarian stromal cells': '91.4', 'Undifferentiated cells': '109.4', 'T-cells': '99.0', 'B-cells': '73.0', 'Plasma cells': '115.2', 'Nk-cells': '88.0', 'Granulocytes': '108.2', 'Monocytes': '82.0', 'Macrophages': '95.0', 'Hofbauer cells': '156.9', 'Kupffer cells': '82.8', 'Dendritic cells': '50.9', 'Langerhans cells': '0.008', 'Erythroid cells': '-0.044', 'Adipocytes (Subcutaneous)': '0.113', 'Adipocytes (Visceral)': '-0.106', 'Breast glandular cells (progenitors)': '0.124', 'Adipocytes (Breast)': '0.018', 'Colon enterocytes': '-0.216', 'Colon enteroendocrine cells': '0.184', 'Enteric glia cells': '-0.077', 'Mitotic cells (Colon)': '-0.259', 'Mitotic cells (Heart)': '0.452', 'Podocytes': '-0.026', 'Ascending Loop of Henle cells': '0.417', 'Intercalated cells': '0.040', 'Cholangiocyte': '0.353', 'NK-cells (Liver)': '-0.393', 'Respiratory ciliated cells': '-0.041', 'Mitotic cells (Lung)': '0.061', 'NK-cells (Lung)': '-0.190', 'B-cells (Lung)': '-0.250', 'Alpha cells': '0.364', 'Beta cells': '0.207', 'Prostate glandular cells': '0.128', 'Prostate basal glandular cells': '0.317', 'Urothelial cells': '0.039', 'Keratinocyte (other)': '0.159', 'Keratinocyte (granular)': '0.175', 'Hair cortex cells': '0.092', 'Inner root sheath cells': '0.080', 'Outer root sheath cells': '-0.104', 'Sebaceous gland cells': '-0.037', 'Eccrine sweat gland cells': '-0.230', 'Adipocytes (Skin)': '-0.005', 'Mitotic cells (Skin)': '0.000', 'Parietal cells': '-0.663', 'Chief cells': '-0.522', 'Gastric mucous cells': '-0.433', 'Gastric enteroendocrine cells': '-0.437', 'Mitotic cells (Stomach)': '0.036', 'Parafollicular cells': '0.087', 'Thyroid glandular cells': '0.272', 'Mitotic cells (Thyroid)': '-0.144', 'Adrenal cortex cells': '0.283', 'Adrenal medulla cells': '0.038', 'Mitotic cells (Adrenal gland)': '0.292', 'Minor salivary glandular cells': '0.406', 'Minor salivary gland ductal cells': '-0.134', 'Minor salivary gland basal cells': '0.544', 'Mitotic cells (Minor salivary gland)': '0.611', 'Adipocytes (Minor salivary gland)': '0.305', 'Somatotropes': '0.125', 'Lactotropes': '-0.063', 'Gonadotropes': '-0.141', 'Corticotropes': '0.022', 'Thyrotropes': '0.096', 'Undifferentiated cells (Pituitary gland)': '0.196', 'Mitotic cells (Spleen)': '-0.305', 'Platelets': '-0.171', 'Erythrocytes': '-0.056', 'Hematopoietic stem cells': '-0.290', 'B-cells (Spleen)': '0.231', 'NK-cells (Spleen)': '0.204', 'Amygdala excitatory': '14.6', 'Cerebellar inhibitory': '27.1', 'Cge interneuron': '30.2', 'Deep-layer corticothalamic and 6b': '23.1', 'Deep-layer intratelencephalic': '22.2', 'Deep-layer near-projecting': '26.1', 'Eccentric medium spiny neuron': '15.2', 'Hippocampal ca1-3': '16.1', 'Hippocampal ca4': '36.0', 'Hippocampal dentate gyrus': '27.6', 'Lamp5-lhx6 and chandelier': '24.7', 'Lower rhombic lip': '30.2', 'Mammillary body': '18.7', 'Medium spiny neuron': '14.4', 'Mge interneuron': '20.1', 'Midbrain-derived inhibitory': '20.8', 'Miscellaneous': '22.4', 'Splatter': '26.9', 'Thalamic excitatory': '28.8', 'Upper rhombic lip': '37.2', 'Upper-layer intratelencephalic': '20.2', 'Astrocyte': '28.9', 'Bergmann glia': '26.3', 'Central nervous system macrophage': '15.2', 'Choroid plexus epithelial cell': '18.4', 'Committed oligodendrocyte precursor': '26.0', 'Ependymal cell': '23.2', 'Oligodendrocyte': '30.8', 'Oligodendrocyte precursor cell': '26.9', 'Endothelial cell': '29.9', 'Pericyte': '38.9', 'Vascular associated smooth muscle cell': '42.2', 'Fibroblast': '17.4', 'Leukocyte': '25.7', 'Basophil': '124.7', 'Eosinophil': '150.2', 'Neutrophil': '36.7', 'Classical monocyte': '53.9', 'Non-classical monocyte': '76.5', 'Intermediate monocyte': '205.6', 'T-reg': '247.0', 'GdT-cell': '164.0', 'MAIT T-cell': '275.4', 'Memory CD4 T-cell': '192.4', 'Naive CD4 T-cell': '87.1', 'Memory CD8 T-cell': '179.4', 'Naive CD8 T-cell': '100.7', 'Memory B-cell': '143.5', 'Naive B-cell': '44.7', 'Plasmacytoid DC': '191.7', 'Myeloid DC': '220.8', 'NK-cell': '111.7', 'Total PBMC': '235.9', 'Vd2 gdTCR': '257.3', 'Memory CD4 T-cell Th1\\/Th17': '97.5', 'Memory CD4 T-cell Th17': '120.9', 'Memory CD4 T-cell Th2': '111.0', 'Non-Vd2 gdTCR': '225.5', 'Memory CD4 T-cell Th1': '100.2', 'Memory CD4 T-cell TFH': '109.6', 'Terminal effector memory CD4 T-cell': '204.2', 'Central memory CD8 T-cell': '237.6', 'Effector memory CD8 T-cell': '269.5', 'Terminal effector memory CD8 T-cell': '235.2', 'Non-switched memory B-cell': '176.1', 'Plasmablast': '253.5', 'Switched memory B-cell': '204.0', 'Exhausted memory B-cell': '175.9', 'Progenitor cell': '130.8', 'Memory T-reg': '133.4', 'Naive CD4 T-cell activated': '104.1', 'Naive CD8 T-cell activated': '124.3', 'Naive T-reg': '85.6'}
2KRK, 3KW6, 5GJQ, 5GJR, 5L4G, 5LN3, 5M32, 5T0C, 5T0G, 5T0H, 5T0I, 5T0J, 5VFP, 5VFQ, 5VFR, 5VFS, 5VFT, 5VFU, 5VGZ, 5VHF, 5VHH, 5VHI, 5VHJ, 5VHM, 5VHN, 5VHO, 5VHP, 5VHQ, 5VHR, 5VHS, 6MSB, 6MSD, 6MSG, 6MSH, 6MSJ, 6MSK, 6WJD, 6WJN, 7QXN, 7QXP, 7QXU, 7QXW, 7QXX, 7QY7, 7QYA, 7QYB, 7W37, 7W38, 7W39, 7W3A, 7W3B, 7W3C, 7W3F, 7W3G, 7W3H, 7W3I, 7W3J, 7W3K, 7W3M, 8CVT
{'Adipose Tissue': 161.09560631229235, 'Adrenal Gland': 155.02581395348835, 'Bladder': 197.40952380952385, 'Blood': 78.2083487621098, 'Blood Vessel': 210.6690337078651, 'Brain': 147.4643754731264, 'Breast': 163.39995642701524, 'Cervix Uteri': 210.83157894736843, 'Colon': 176.10761232349165, 'Esophagus': 191.49862283737025, 'Fallopian Tube': 212.54444444444445, 'Heart': 89.87470847851336, 'Kidney': 125.28314606741574, 'Liver': 80.37898230088496, 'Lung': 161.70849480968857, 'Muscle': 191.37, 'Nerve': 223.9032310177706, 'Ovary': 154.6528888888889, 'Pancreas': 59.61679878048781, 'Pituitary': 204.652296819788, 'Prostate': 200.1361224489796, 'Salivary Gland': 130.3661111111111, 'Skin': 191.77589828634603, 'Small Intestine': 138.50459893048128, 'Spleen': 175.5241908713693, 'Stomach': 138.2191086350975, 'Testis': 235.20138504155125, 'Thyroid': 209.86646248085756, 'Uterus': 201.04788732394368, 'Vagina': 179.6326923076923}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
81.950443
0.410419
1,812
O60260
P62258
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
YWHAE
MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ
Homo sapiens
Nucleus, Cytoplasm, Melanosome
Low tissue specificity
{'Ciliated cells': '424.3', 'Basal respiratory cells': '441.6', 'Club cells': '256.1', 'Ionocytes': '290.8', 'Mucus glandular cells': '252.9', 'Serous glandular cells': '261.5', 'Gastric mucus-secreting cells': '192.8', 'Proximal enterocytes': '264.3', 'Paneth cells': '289.2', 'Distal enterocytes': '292.8', 'Intestinal goblet cells': '274.5', 'Exocrine glandular cells': '-0.776', 'Basal prostatic cells': '279.5', 'Prostatic glandular cells': '253.2', 'Breast glandular cells': '0.030', 'Breast myoepithelial cells': '0.048', 'Glandular and luminal cells': '517.5', 'Secretory cells': '434.1', 'Basal keratinocytes': '491.6', 'Suprabasal keratinocytes': '524.6', 'Basal squamous epithelial cells': '274.8', 'Squamous epithelial cells': '334.7', 'Alveolar cells type 1': '0.214', 'Alveolar cells type 2': '-0.119', 'Salivary duct cells': '245.1', 'Ductal cells': '0.637', 'Hepatocytes': '0.549', 'Cholangiocytes': '232.8', 'Proximal tubular cells': '0.265', 'Distal tubular cells': '777.6', 'Collecting duct cells': '355.9', 'Mesothelial cells': '0.260', 'Sertoli cells': '0.210', 'Granulosa cells': '299.8', 'Enteroendocrine cells': '285.7', 'Pancreatic endocrine cells': '577.3', 'Leydig cells': '0.227', 'Excitatory neurons': '70.9', 'Inhibitory neurons': '69.3', 'Cone photoreceptor cells': '173.3', 'Rod photoreceptor cells': '139.7', 'Bipolar cells': '146.5', 'Horizontal cells': '79.3', 'Astrocytes': '79.0', 'Oligodendrocyte precursor cells': '53.3', 'Oligodendrocytes': '104.4', 'Microglial cells': '57.3', 'Muller glia cells': '316.3', 'Schwann cells': '0.133', 'Spermatogonia': '0.567', 'Spermatocytes': '0.719', 'Early spermatids': '0.300', 'Late spermatids': '-0.108', 'Oocytes': '505.8', 'Cytotrophoblasts': '476.3', 'Syncytiotrophoblasts': '530.5', 'Extravillous trophoblasts': '764.3', 'Endothelial cells': '315.4', 'Lymphatic endothelial cells': '403.8', 'Cardiomyocytes': '0.662', 'Skeletal myocytes': '-0.139', 'Smooth muscle cells': '221.8', 'Adipocytes': '349.8', 'Melanocytes': '0.294', 'Fibroblasts': '275.5', 'Peritubular cells': '0.079', 'Endometrial stromal cells': '399.4', 'Ovarian stromal cells': '296.8', 'Undifferentiated cells': '339.6', 'T-cells': '121.4', 'B-cells': '136.2', 'Plasma cells': '295.9', 'Nk-cells': '102.2', 'Granulocytes': '257.4', 'Monocytes': '279.9', 'Macrophages': '237.7', 'Hofbauer cells': '364.5', 'Kupffer cells': '231.8', 'Dendritic cells': '167.4', 'Langerhans cells': '0.129', 'Erythroid cells': '-0.060', 'Adipocytes (Subcutaneous)': '0.456', 'Adipocytes (Visceral)': '0.032', 'Breast glandular cells (progenitors)': '-0.046', 'Adipocytes (Breast)': '0.043', 'Colon enterocytes': '-0.140', 'Colon enteroendocrine cells': '0.433', 'Enteric glia cells': '0.306', 'Mitotic cells (Colon)': '-0.069', 'Mitotic cells (Heart)': '0.491', 'Podocytes': '0.123', 'Ascending Loop of Henle cells': '0.388', 'Intercalated cells': '0.133', 'Cholangiocyte': '0.344', 'NK-cells (Liver)': '-0.386', 'Respiratory ciliated cells': '0.004', 'Mitotic cells (Lung)': '0.007', 'NK-cells (Lung)': '0.155', 'B-cells (Lung)': '-0.115', 'Alpha cells': '0.368', 'Beta cells': '0.154', 'Prostate glandular cells': '0.277', 'Prostate basal glandular cells': '0.308', 'Urothelial cells': '0.135', 'Keratinocyte (other)': '0.327', 'Keratinocyte (granular)': '-0.214', 'Hair cortex cells': '0.128', 'Inner root sheath cells': '0.247', 'Outer root sheath cells': '0.288', 'Sebaceous gland cells': '0.037', 'Eccrine sweat gland cells': '-0.025', 'Adipocytes (Skin)': '-0.186', 'Mitotic cells (Skin)': '0.485', 'Parietal cells': '-0.505', 'Chief cells': '-0.344', 'Gastric mucous cells': '-0.127', 'Gastric enteroendocrine cells': '-0.239', 'Mitotic cells (Stomach)': '0.293', 'Parafollicular cells': '0.190', 'Thyroid glandular cells': '0.636', 'Mitotic cells (Thyroid)': '-0.111', 'Adrenal cortex cells': '0.547', 'Adrenal medulla cells': '0.086', 'Mitotic cells (Adrenal gland)': '0.331', 'Minor salivary glandular cells': '0.358', 'Minor salivary gland ductal cells': '-0.184', 'Minor salivary gland basal cells': '0.610', 'Mitotic cells (Minor salivary gland)': '0.681', 'Adipocytes (Minor salivary gland)': '0.192', 'Somatotropes': '-0.050', 'Lactotropes': '0.027', 'Gonadotropes': '0.067', 'Corticotropes': '0.010', 'Thyrotropes': '0.259', 'Undifferentiated cells (Pituitary gland)': '0.244', 'Mitotic cells (Spleen)': '-0.049', 'Platelets': '-0.142', 'Erythrocytes': '-0.072', 'Hematopoietic stem cells': '-0.131', 'B-cells (Spleen)': '-0.023', 'NK-cells (Spleen)': '0.034', 'Amygdala excitatory': '117.0', 'Cerebellar inhibitory': '144.3', 'Cge interneuron': '146.4', 'Deep-layer corticothalamic and 6b': '122.4', 'Deep-layer intratelencephalic': '126.4', 'Deep-layer near-projecting': '123.0', 'Eccentric medium spiny neuron': '124.7', 'Hippocampal ca1-3': '119.2', 'Hippocampal ca4': '239.6', 'Hippocampal dentate gyrus': '154.0', 'Lamp5-lhx6 and chandelier': '146.1', 'Lower rhombic lip': '154.1', 'Mammillary body': '107.4', 'Medium spiny neuron': '109.4', 'Mge interneuron': '119.2', 'Midbrain-derived inhibitory': '150.9', 'Miscellaneous': '158.3', 'Splatter': '132.1', 'Thalamic excitatory': '127.0', 'Upper rhombic lip': '175.2', 'Upper-layer intratelencephalic': '122.1', 'Astrocyte': '139.6', 'Bergmann glia': '169.7', 'Central nervous system macrophage': '157.6', 'Choroid plexus epithelial cell': '160.4', 'Committed oligodendrocyte precursor': '129.2', 'Ependymal cell': '198.5', 'Oligodendrocyte': '161.8', 'Oligodendrocyte precursor cell': '133.5', 'Endothelial cell': '184.0', 'Pericyte': '145.5', 'Vascular associated smooth muscle cell': '165.6', 'Fibroblast': '130.0', 'Leukocyte': '136.0', 'Basophil': '77.6', 'Eosinophil': '41.2', 'Neutrophil': '62.1', 'Classical monocyte': '135.0', 'Non-classical monocyte': '108.4', 'Intermediate monocyte': '175.3', 'T-reg': '85.3', 'GdT-cell': '47.4', 'MAIT T-cell': '65.9', 'Memory CD4 T-cell': '67.4', 'Naive CD4 T-cell': '64.2', 'Memory CD8 T-cell': '55.1', 'Naive CD8 T-cell': '57.1', 'Memory B-cell': '78.3', 'Naive B-cell': '50.6', 'Plasmacytoid DC': '216.4', 'Myeloid DC': '297.9', 'NK-cell': '49.6', 'Total PBMC': '137.2', 'Vd2 gdTCR': '63.2', 'Memory CD4 T-cell Th1\\/Th17': '64.7', 'Memory CD4 T-cell Th17': '68.2', 'Memory CD4 T-cell Th2': '68.5', 'Non-Vd2 gdTCR': '66.4', 'Memory CD4 T-cell Th1': '61.7', 'Memory CD4 T-cell TFH': '62.6', 'Terminal effector memory CD4 T-cell': '55.8', 'Central memory CD8 T-cell': '73.4', 'Effector memory CD8 T-cell': '103.8', 'Terminal effector memory CD8 T-cell': '69.3', 'Non-switched memory B-cell': '87.4', 'Plasmablast': '307.0', 'Switched memory B-cell': '104.5', 'Exhausted memory B-cell': '102.5', 'Progenitor cell': '227.5', 'Memory T-reg': '72.3', 'Naive CD4 T-cell activated': '269.8', 'Naive CD8 T-cell activated': '238.2', 'Naive T-reg': '65.5'}
2BR9, 3UAL, 3UBW, 6EIH, 7C8E, 7V9B, 8DGM, 8DGN, 8DGP, 8DP5, 8Q1S
{'Adipose Tissue': 282.4242026578073, 'Adrenal Gland': 252.36085271317828, 'Bladder': 220.17619047619047, 'Blood': 125.89651453175456, 'Blood Vessel': 205.11617977528087, 'Brain': 463.016790310371, 'Breast': 286.5224400871459, 'Cervix Uteri': 281.59473684210525, 'Colon': 198.6942362002567, 'Esophagus': 227.5683114186851, 'Fallopian Tube': 262.32222222222225, 'Heart': 164.739718931475, 'Kidney': 191.2403370786517, 'Liver': 109.85283185840709, 'Lung': 298.93287197231837, 'Muscle': 326.5930261519303, 'Nerve': 403.3833602584814, 'Ovary': 305.02222222222224, 'Pancreas': 98.70567073170731, 'Pituitary': 336.0583038869258, 'Prostate': 245.41714285714284, 'Salivary Gland': 232.34753086419755, 'Skin': 333.7332227750138, 'Small Intestine': 167.8736898395722, 'Spleen': 155.79390041493775, 'Stomach': 159.79972144846795, 'Testis': 339.16260387811633, 'Thyroid': 340.31087289433384, 'Uterus': 291.9154929577465, 'Vagina': 293.3044871794872}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
92.867529
0.328392
2,542
O60260
P68363
18195004, E3Net
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
TUBA1B
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
Homo sapiens
Cytoplasm, cytoskeleton
Low tissue specificity
{'Ciliated cells': '286.5', 'Basal respiratory cells': '830.3', 'Club cells': '332.6', 'Ionocytes': '372.9', 'Mucus glandular cells': '165.0', 'Serous glandular cells': '289.1', 'Gastric mucus-secreting cells': '215.8', 'Proximal enterocytes': '220.7', 'Paneth cells': '319.7', 'Distal enterocytes': '417.9', 'Intestinal goblet cells': '466.2', 'Exocrine glandular cells': '-0.584', 'Basal prostatic cells': '251.4', 'Prostatic glandular cells': '73.2', 'Breast glandular cells': '-0.136', 'Breast myoepithelial cells': '-0.071', 'Glandular and luminal cells': '210.9', 'Secretory cells': '488.2', 'Basal keratinocytes': '491.9', 'Suprabasal keratinocytes': '377.0', 'Basal squamous epithelial cells': '313.8', 'Squamous epithelial cells': '532.6', 'Alveolar cells type 1': '-0.139', 'Alveolar cells type 2': '0.006', 'Salivary duct cells': '218.0', 'Ductal cells': '0.657', 'Hepatocytes': '0.510', 'Cholangiocytes': '82.0', 'Proximal tubular cells': '0.208', 'Distal tubular cells': '273.5', 'Collecting duct cells': '221.7', 'Mesothelial cells': '-0.047', 'Sertoli cells': '0.608', 'Granulosa cells': '555.2', 'Enteroendocrine cells': '294.0', 'Pancreatic endocrine cells': '1288.8', 'Leydig cells': '0.584', 'Excitatory neurons': '195.1', 'Inhibitory neurons': '94.8', 'Cone photoreceptor cells': '1075.6', 'Rod photoreceptor cells': '859.2', 'Bipolar cells': '454.4', 'Horizontal cells': '452.6', 'Astrocytes': '34.7', 'Oligodendrocyte precursor cells': '32.5', 'Oligodendrocytes': '76.9', 'Microglial cells': '65.3', 'Muller glia cells': '458.7', 'Schwann cells': '0.158', 'Spermatogonia': '0.760', 'Spermatocytes': '0.374', 'Early spermatids': '-0.323', 'Late spermatids': '-0.455', 'Oocytes': '697.7', 'Cytotrophoblasts': '1264.3', 'Syncytiotrophoblasts': '317.3', 'Extravillous trophoblasts': '2882.9', 'Endothelial cells': '539.6', 'Lymphatic endothelial cells': '576.3', 'Cardiomyocytes': '0.474', 'Skeletal myocytes': '-0.292', 'Smooth muscle cells': '588.4', 'Adipocytes': '625.8', 'Melanocytes': '0.295', 'Fibroblasts': '623.2', 'Peritubular cells': '0.326', 'Endometrial stromal cells': '199.4', 'Ovarian stromal cells': '384.1', 'Undifferentiated cells': '1003.2', 'T-cells': '410.3', 'B-cells': '400.1', 'Plasma cells': '736.9', 'Nk-cells': '262.3', 'Granulocytes': '550.2', 'Monocytes': '575.4', 'Macrophages': '636.7', 'Hofbauer cells': '1915.7', 'Kupffer cells': '294.7', 'Dendritic cells': '546.9', 'Langerhans cells': '0.171', 'Erythroid cells': '-0.092', 'Adipocytes (Subcutaneous)': '-0.234', 'Adipocytes (Visceral)': '-0.003', 'Breast glandular cells (progenitors)': '-0.134', 'Adipocytes (Breast)': '0.262', 'Colon enterocytes': '-0.066', 'Colon enteroendocrine cells': '0.242', 'Enteric glia cells': '-0.048', 'Mitotic cells (Colon)': '0.074', 'Mitotic cells (Heart)': '0.537', 'Podocytes': '-0.054', 'Ascending Loop of Henle cells': '0.161', 'Intercalated cells': '-0.093', 'Cholangiocyte': '0.390', 'NK-cells (Liver)': '-0.376', 'Respiratory ciliated cells': '-0.096', 'Mitotic cells (Lung)': '0.198', 'NK-cells (Lung)': '0.049', 'B-cells (Lung)': '-0.031', 'Alpha cells': '0.331', 'Beta cells': '0.218', 'Prostate glandular cells': '-0.337', 'Prostate basal glandular cells': '-0.097', 'Urothelial cells': '-0.048', 'Keratinocyte (other)': '-0.088', 'Keratinocyte (granular)': '-0.152', 'Hair cortex cells': '0.369', 'Inner root sheath cells': '0.392', 'Outer root sheath cells': '0.393', 'Sebaceous gland cells': '0.273', 'Eccrine sweat gland cells': '0.173', 'Adipocytes (Skin)': '0.190', 'Mitotic cells (Skin)': '0.422', 'Parietal cells': '-0.629', 'Chief cells': '-0.532', 'Gastric mucous cells': '-0.217', 'Gastric enteroendocrine cells': '-0.412', 'Mitotic cells (Stomach)': '0.347', 'Parafollicular cells': '0.022', 'Thyroid glandular cells': '0.053', 'Mitotic cells (Thyroid)': '0.075', 'Adrenal cortex cells': '0.283', 'Adrenal medulla cells': '0.123', 'Mitotic cells (Adrenal gland)': '0.365', 'Minor salivary glandular cells': '0.391', 'Minor salivary gland ductal cells': '-0.094', 'Minor salivary gland basal cells': '0.507', 'Mitotic cells (Minor salivary gland)': '0.585', 'Adipocytes (Minor salivary gland)': '0.194', 'Somatotropes': '-0.248', 'Lactotropes': '-0.155', 'Gonadotropes': '-0.060', 'Corticotropes': '-0.203', 'Thyrotropes': '0.029', 'Undifferentiated cells (Pituitary gland)': '0.306', 'Mitotic cells (Spleen)': '0.384', 'Platelets': '0.193', 'Erythrocytes': '0.072', 'Hematopoietic stem cells': '0.159', 'B-cells (Spleen)': '-0.136', 'NK-cells (Spleen)': '-0.157', 'Amygdala excitatory': '176.7', 'Cerebellar inhibitory': '129.4', 'Cge interneuron': '176.2', 'Deep-layer corticothalamic and 6b': '347.8', 'Deep-layer intratelencephalic': '311.5', 'Deep-layer near-projecting': '360.4', 'Eccentric medium spiny neuron': '132.2', 'Hippocampal ca1-3': '191.9', 'Hippocampal ca4': '273.0', 'Hippocampal dentate gyrus': '114.7', 'Lamp5-lhx6 and chandelier': '197.6', 'Lower rhombic lip': '356.0', 'Mammillary body': '207.9', 'Medium spiny neuron': '81.3', 'Mge interneuron': '167.4', 'Midbrain-derived inhibitory': '180.2', 'Miscellaneous': '283.8', 'Splatter': '263.1', 'Thalamic excitatory': '476.2', 'Upper rhombic lip': '196.3', 'Upper-layer intratelencephalic': '167.0', 'Astrocyte': '36.3', 'Bergmann glia': '64.0', 'Central nervous system macrophage': '180.9', 'Choroid plexus epithelial cell': '48.5', 'Committed oligodendrocyte precursor': '85.7', 'Ependymal cell': '56.3', 'Oligodendrocyte': '117.7', 'Oligodendrocyte precursor cell': '37.3', 'Endothelial cell': '129.5', 'Pericyte': '144.7', 'Vascular associated smooth muscle cell': '136.0', 'Fibroblast': '84.1', 'Leukocyte': '91.6', 'Basophil': '632.3', 'Eosinophil': '412.1', 'Neutrophil': '1193.9', 'Classical monocyte': '19.9', 'Non-classical monocyte': '54.0', 'Intermediate monocyte': '1715.5', 'T-reg': '687.1', 'GdT-cell': '242.2', 'MAIT T-cell': '547.9', 'Memory CD4 T-cell': '230.6', 'Naive CD4 T-cell': '16.9', 'Memory CD8 T-cell': '225.3', 'Naive CD8 T-cell': '16.7', 'Memory B-cell': '269.8', 'Naive B-cell': '16.0', 'Plasmacytoid DC': '2249.9', 'Myeloid DC': '1855.0', 'NK-cell': '25.6', 'Total PBMC': '869.5', 'Vd2 gdTCR': '537.9', 'Memory CD4 T-cell Th1\\/Th17': '19.6', 'Memory CD4 T-cell Th17': '22.4', 'Memory CD4 T-cell Th2': '25.4', 'Non-Vd2 gdTCR': '631.5', 'Memory CD4 T-cell Th1': '24.4', 'Memory CD4 T-cell TFH': '16.7', 'Terminal effector memory CD4 T-cell': '649.6', 'Central memory CD8 T-cell': '417.5', 'Effector memory CD8 T-cell': '827.7', 'Terminal effector memory CD8 T-cell': '620.1', 'Non-switched memory B-cell': '487.0', 'Plasmablast': '1435.6', 'Switched memory B-cell': '569.7', 'Exhausted memory B-cell': '563.7', 'Progenitor cell': '821.7', 'Memory T-reg': '28.0', 'Naive CD4 T-cell activated': '44.9', 'Naive CD8 T-cell activated': '42.2', 'Naive T-reg': '21.0'}
2E4H, 5IJ0, 5IJ9, 5N5N, 6E7B, 6E7C, 6I2I, 6J4V, 6J8O, 6QUS, 6QUY, 6QVE, 6QVJ, 6S8L, 7LXB, 7M18, 7M20, 7PJF, 7SJ7, 7SJ8, 7SJ9, 7SJA, 7Z6S, 7ZCW, 8VA2, 8VRJ, 8VRK, 8VT7, 9BP6
{'Adipose Tissue': 251.19240033222593, 'Adrenal Gland': 132.0524418604651, 'Bladder': 251.1238095238095, 'Blood': 272.9821442411195, 'Blood Vessel': 389.0347415730337, 'Brain': 337.09721574564725, 'Breast': 218.0566448801743, 'Cervix Uteri': 191.7821052631579, 'Colon': 232.0481643132221, 'Esophagus': 280.6181937716263, 'Fallopian Tube': 265.17777777777775, 'Heart': 120.98832520325205, 'Kidney': 97.62573033707866, 'Liver': 44.95792920353983, 'Lung': 319.6936678200692, 'Muscle': 65.11414694894147, 'Nerve': 479.7363489499192, 'Ovary': 203.25622222222225, 'Pancreas': 39.68345731707317, 'Pituitary': 166.9404593639576, 'Prostate': 136.13310204081634, 'Salivary Gland': 151.70987654320987, 'Skin': 397.9249695964621, 'Small Intestine': 180.09106951871658, 'Spleen': 204.1860165975104, 'Stomach': 160.18885793871868, 'Testis': 207.90360110803323, 'Thyroid': 174.93981623277182, 'Uterus': 297.5524647887324, 'Vagina': 206.48506410256408}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
91.993747
0.271286
1,765
O60260
P78527
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PRKDC
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM
Homo sapiens
Nucleus, Nucleus, nucleolus
Low tissue specificity
{'Ciliated cells': '57.9', 'Basal respiratory cells': '56.3', 'Club cells': '66.4', 'Ionocytes': '29.8', 'Mucus glandular cells': '76.5', 'Serous glandular cells': '79.1', 'Gastric mucus-secreting cells': '61.9', 'Proximal enterocytes': '10.6', 'Paneth cells': '20.8', 'Distal enterocytes': '15.3', 'Intestinal goblet cells': '28.1', 'Exocrine glandular cells': '-0.555', 'Basal prostatic cells': '74.3', 'Prostatic glandular cells': '96.9', 'Breast glandular cells': '0.373', 'Breast myoepithelial cells': '0.339', 'Glandular and luminal cells': '73.9', 'Secretory cells': '86.4', 'Basal keratinocytes': '93.8', 'Suprabasal keratinocytes': '84.0', 'Basal squamous epithelial cells': '75.6', 'Squamous epithelial cells': '82.3', 'Alveolar cells type 1': '-0.102', 'Alveolar cells type 2': '0.071', 'Salivary duct cells': '99.5', 'Ductal cells': '0.578', 'Hepatocytes': '0.596', 'Cholangiocytes': '22.9', 'Proximal tubular cells': '0.158', 'Distal tubular cells': '18.4', 'Collecting duct cells': '40.8', 'Mesothelial cells': '0.142', 'Sertoli cells': '0.199', 'Granulosa cells': '45.2', 'Enteroendocrine cells': '26.7', 'Pancreatic endocrine cells': '25.5', 'Leydig cells': '0.245', 'Excitatory neurons': '82.7', 'Inhibitory neurons': '73.9', 'Cone photoreceptor cells': '107.0', 'Rod photoreceptor cells': '122.4', 'Bipolar cells': '103.8', 'Horizontal cells': '68.0', 'Astrocytes': '53.9', 'Oligodendrocyte precursor cells': '76.9', 'Oligodendrocytes': '70.8', 'Microglial cells': '59.0', 'Muller glia cells': '64.6', 'Schwann cells': '0.104', 'Spermatogonia': '0.634', 'Spermatocytes': '0.782', 'Early spermatids': '-0.080', 'Late spermatids': '-0.252', 'Oocytes': '34.6', 'Cytotrophoblasts': '63.2', 'Syncytiotrophoblasts': '29.0', 'Extravillous trophoblasts': '58.0', 'Endothelial cells': '69.8', 'Lymphatic endothelial cells': '77.7', 'Cardiomyocytes': '0.616', 'Skeletal myocytes': '-0.295', 'Smooth muscle cells': '72.6', 'Adipocytes': '66.9', 'Melanocytes': '0.215', 'Fibroblasts': '85.0', 'Peritubular cells': '0.147', 'Endometrial stromal cells': '164.1', 'Ovarian stromal cells': '45.3', 'Undifferentiated cells': '72.9', 'T-cells': '83.3', 'B-cells': '72.3', 'Plasma cells': '88.2', 'Nk-cells': '70.9', 'Granulocytes': '72.3', 'Monocytes': '76.8', 'Macrophages': '69.3', 'Hofbauer cells': '32.1', 'Kupffer cells': '46.8', 'Dendritic cells': '71.0', 'Langerhans cells': '0.142', 'Erythroid cells': '-0.118', 'Adipocytes (Subcutaneous)': '-0.065', 'Adipocytes (Visceral)': '-0.157', 'Breast glandular cells (progenitors)': '0.236', 'Adipocytes (Breast)': '-0.186', 'Colon enterocytes': '-0.067', 'Colon enteroendocrine cells': '0.165', 'Enteric glia cells': '-0.276', 'Mitotic cells (Colon)': '0.029', 'Mitotic cells (Heart)': '0.511', 'Podocytes': '-0.149', 'Ascending Loop of Henle cells': '0.512', 'Intercalated cells': '-0.019', 'Cholangiocyte': '0.295', 'NK-cells (Liver)': '-0.386', 'Respiratory ciliated cells': '-0.030', 'Mitotic cells (Lung)': '0.161', 'NK-cells (Lung)': '-0.040', 'B-cells (Lung)': '-0.101', 'Alpha cells': '0.351', 'Beta cells': '0.181', 'Prostate glandular cells': '-0.118', 'Prostate basal glandular cells': '0.140', 'Urothelial cells': '0.037', 'Keratinocyte (other)': '0.064', 'Keratinocyte (granular)': '-0.086', 'Hair cortex cells': '0.175', 'Inner root sheath cells': '0.249', 'Outer root sheath cells': '0.230', 'Sebaceous gland cells': '0.203', 'Eccrine sweat gland cells': '0.051', 'Adipocytes (Skin)': '0.049', 'Mitotic cells (Skin)': '0.376', 'Parietal cells': '-0.575', 'Chief cells': '-0.478', 'Gastric mucous cells': '-0.293', 'Gastric enteroendocrine cells': '-0.385', 'Mitotic cells (Stomach)': '0.213', 'Parafollicular cells': '0.072', 'Thyroid glandular cells': '0.340', 'Mitotic cells (Thyroid)': '0.079', 'Adrenal cortex cells': '0.644', 'Adrenal medulla cells': '0.046', 'Mitotic cells (Adrenal gland)': '0.433', 'Minor salivary glandular cells': '0.439', 'Minor salivary gland ductal cells': '-0.015', 'Minor salivary gland basal cells': '0.579', 'Mitotic cells (Minor salivary gland)': '0.651', 'Adipocytes (Minor salivary gland)': '0.203', 'Somatotropes': '0.258', 'Lactotropes': '-0.014', 'Gonadotropes': '0.011', 'Corticotropes': '-0.180', 'Thyrotropes': '0.055', 'Undifferentiated cells (Pituitary gland)': '0.062', 'Mitotic cells (Spleen)': '0.053', 'Platelets': '0.028', 'Erythrocytes': '-0.120', 'Hematopoietic stem cells': '-0.099', 'B-cells (Spleen)': '0.390', 'NK-cells (Spleen)': '0.148', 'Amygdala excitatory': '142.6', 'Cerebellar inhibitory': '146.2', 'Cge interneuron': '135.0', 'Deep-layer corticothalamic and 6b': '133.8', 'Deep-layer intratelencephalic': '137.5', 'Deep-layer near-projecting': '131.3', 'Eccentric medium spiny neuron': '139.9', 'Hippocampal ca1-3': '135.7', 'Hippocampal ca4': '123.3', 'Hippocampal dentate gyrus': '129.0', 'Lamp5-lhx6 and chandelier': '135.5', 'Lower rhombic lip': '112.4', 'Mammillary body': '123.2', 'Medium spiny neuron': '167.6', 'Mge interneuron': '136.5', 'Midbrain-derived inhibitory': '139.6', 'Miscellaneous': '123.6', 'Splatter': '117.7', 'Thalamic excitatory': '124.5', 'Upper rhombic lip': '129.3', 'Upper-layer intratelencephalic': '169.8', 'Astrocyte': '119.7', 'Bergmann glia': '93.2', 'Central nervous system macrophage': '186.6', 'Choroid plexus epithelial cell': '105.3', 'Committed oligodendrocyte precursor': '136.5', 'Ependymal cell': '120.6', 'Oligodendrocyte': '146.7', 'Oligodendrocyte precursor cell': '135.6', 'Endothelial cell': '134.4', 'Pericyte': '131.0', 'Vascular associated smooth muscle cell': '121.8', 'Fibroblast': '132.1', 'Leukocyte': '190.4', 'Basophil': '10.1', 'Eosinophil': '2.3', 'Neutrophil': '93.4', 'Classical monocyte': '26.1', 'Non-classical monocyte': '43.3', 'Intermediate monocyte': '18.8', 'T-reg': '22.9', 'GdT-cell': '5.1', 'MAIT T-cell': '30.4', 'Memory CD4 T-cell': '7.1', 'Naive CD4 T-cell': '65.3', 'Memory CD8 T-cell': '5.4', 'Naive CD8 T-cell': '60.5', 'Memory B-cell': '7.6', 'Naive B-cell': '61.9', 'Plasmacytoid DC': '19.8', 'Myeloid DC': '22.3', 'NK-cell': '62.3', 'Total PBMC': '16.5', 'Vd2 gdTCR': '27.0', 'Memory CD4 T-cell Th1\\/Th17': '64.4', 'Memory CD4 T-cell Th17': '60.4', 'Memory CD4 T-cell Th2': '63.1', 'Non-Vd2 gdTCR': '27.2', 'Memory CD4 T-cell Th1': '59.1', 'Memory CD4 T-cell TFH': '59.8', 'Terminal effector memory CD4 T-cell': '26.2', 'Central memory CD8 T-cell': '30.4', 'Effector memory CD8 T-cell': '24.2', 'Terminal effector memory CD8 T-cell': '24.8', 'Non-switched memory B-cell': '29.5', 'Plasmablast': '17.6', 'Switched memory B-cell': '29.9', 'Exhausted memory B-cell': '23.7', 'Progenitor cell': '20.0', 'Memory T-reg': '62.8', 'Naive CD4 T-cell activated': '165.5', 'Naive CD8 T-cell activated': '160.7', 'Naive T-reg': '72.2'}
5LUQ, 5W1R, 5Y3R, 6ZFP, 6ZH2, 6ZH4, 6ZH6, 6ZH8, 6ZHA, 6ZHE, 7K0Y, 7K10, 7K11, 7K19, 7K1B, 7K1J, 7K1K, 7K1N, 7LT3, 7NFC, 7NFE, 7OTM, 7OTP, 7OTV, 7OTW, 7OTY, 7SGL, 7SU3, 7SUD, 7TYR, 7Z87, 7Z88, 8BH3, 8BHV, 8BHY, 8BOT, 8EZ9, 8EZA, 8EZB
{'Adipose Tissue': 21.148492524916943, 'Adrenal Gland': 16.29674031007752, 'Bladder': 26.08, 'Blood': 22.009865123789023, 'Blood Vessel': 22.24105393258427, 'Brain': 11.123603217259651, 'Breast': 21.454801742919393, 'Cervix Uteri': 27.129473684210527, 'Colon': 18.746853658536587, 'Esophagus': 21.95435294117647, 'Fallopian Tube': 27.75, 'Heart': 8.994795470383275, 'Kidney': 8.52176404494382, 'Liver': 6.158982300884956, 'Lung': 22.158304498269896, 'Muscle': 15.714290161892905, 'Nerve': 27.140258481421647, 'Ovary': 30.474055555555555, 'Pancreas': 7.590387195121951, 'Pituitary': 20.41936042402827, 'Prostate': 19.30670204081633, 'Salivary Gland': 17.39672839506173, 'Skin': 42.086144278606966, 'Small Intestine': 20.283620320855615, 'Spleen': 20.595614107883815, 'Stomach': 15.52701671309192, 'Testis': 31.30163434903047, 'Thyroid': 22.281787136294028, 'Uterus': 32.89492957746479, 'Vagina': 24.52092307692308}
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null
null
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
null
null
17
O60260
Q00610
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
CLTC
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM
Homo sapiens
Cytoplasmic vesicle membrane, Membrane, coated pit, Melanosome, Cytoplasm, cytoskeleton, spindle
Low tissue specificity
{'Ciliated cells': '107.5', 'Basal respiratory cells': '73.3', 'Club cells': '95.2', 'Ionocytes': '81.4', 'Mucus glandular cells': '90.7', 'Serous glandular cells': '110.3', 'Gastric mucus-secreting cells': '94.9', 'Proximal enterocytes': '91.9', 'Paneth cells': '84.2', 'Distal enterocytes': '171.7', 'Intestinal goblet cells': '100.0', 'Exocrine glandular cells': '-0.525', 'Basal prostatic cells': '119.5', 'Prostatic glandular cells': '152.5', 'Breast glandular cells': '-0.047', 'Breast myoepithelial cells': '-0.093', 'Glandular and luminal cells': '106.4', 'Secretory cells': '62.2', 'Basal keratinocytes': '73.1', 'Suprabasal keratinocytes': '105.9', 'Basal squamous epithelial cells': '42.8', 'Squamous epithelial cells': '60.7', 'Alveolar cells type 1': '-0.036', 'Alveolar cells type 2': '0.324', 'Salivary duct cells': '72.3', 'Ductal cells': '0.606', 'Hepatocytes': '0.599', 'Cholangiocytes': '70.6', 'Proximal tubular cells': '0.375', 'Distal tubular cells': '27.7', 'Collecting duct cells': '60.3', 'Mesothelial cells': '0.116', 'Sertoli cells': '0.597', 'Granulosa cells': '42.1', 'Enteroendocrine cells': '102.6', 'Pancreatic endocrine cells': '71.3', 'Leydig cells': '0.602', 'Excitatory neurons': '133.0', 'Inhibitory neurons': '130.3', 'Cone photoreceptor cells': '105.3', 'Rod photoreceptor cells': '48.0', 'Bipolar cells': '82.8', 'Horizontal cells': '94.4', 'Astrocytes': '76.2', 'Oligodendrocyte precursor cells': '68.9', 'Oligodendrocytes': '115.6', 'Microglial cells': '76.0', 'Muller glia cells': '51.8', 'Schwann cells': '0.089', 'Spermatogonia': '0.721', 'Spermatocytes': '0.547', 'Early spermatids': '-0.349', 'Late spermatids': '-0.597', 'Oocytes': '42.6', 'Cytotrophoblasts': '109.0', 'Syncytiotrophoblasts': '114.5', 'Extravillous trophoblasts': '47.0', 'Endothelial cells': '79.5', 'Lymphatic endothelial cells': '105.5', 'Cardiomyocytes': '0.627', 'Skeletal myocytes': '-0.200', 'Smooth muscle cells': '76.6', 'Adipocytes': '58.2', 'Melanocytes': '0.322', 'Fibroblasts': '97.7', 'Peritubular cells': '0.399', 'Endometrial stromal cells': '90.7', 'Ovarian stromal cells': '30.6', 'Undifferentiated cells': '87.5', 'T-cells': '48.7', 'B-cells': '46.8', 'Plasma cells': '92.2', 'Nk-cells': '45.2', 'Granulocytes': '94.7', 'Monocytes': '117.9', 'Macrophages': '155.5', 'Hofbauer cells': '174.2', 'Kupffer cells': '182.8', 'Dendritic cells': '109.9', 'Langerhans cells': '0.303', 'Erythroid cells': '-0.125', 'Adipocytes (Subcutaneous)': '0.113', 'Adipocytes (Visceral)': '0.025', 'Breast glandular cells (progenitors)': '-0.133', 'Adipocytes (Breast)': '0.299', 'Colon enterocytes': '0.058', 'Colon enteroendocrine cells': '0.190', 'Enteric glia cells': '-0.355', 'Mitotic cells (Colon)': '0.201', 'Mitotic cells (Heart)': '0.541', 'Podocytes': '-0.066', 'Ascending Loop of Henle cells': '0.405', 'Intercalated cells': '0.012', 'Cholangiocyte': '0.305', 'NK-cells (Liver)': '-0.360', 'Respiratory ciliated cells': '-0.129', 'Mitotic cells (Lung)': '0.260', 'NK-cells (Lung)': '-0.232', 'B-cells (Lung)': '-0.253', 'Alpha cells': '0.360', 'Beta cells': '0.203', 'Prostate glandular cells': '0.092', 'Prostate basal glandular cells': '0.042', 'Urothelial cells': '-0.114', 'Keratinocyte (other)': '0.349', 'Keratinocyte (granular)': '0.031', 'Hair cortex cells': '0.079', 'Inner root sheath cells': '0.151', 'Outer root sheath cells': '0.133', 'Sebaceous gland cells': '0.119', 'Eccrine sweat gland cells': '-0.044', 'Adipocytes (Skin)': '-0.063', 'Mitotic cells (Skin)': '0.427', 'Parietal cells': '-0.472', 'Chief cells': '-0.447', 'Gastric mucous cells': '-0.184', 'Gastric enteroendocrine cells': '-0.364', 'Mitotic cells (Stomach)': '0.270', 'Parafollicular cells': '0.095', 'Thyroid glandular cells': '0.454', 'Mitotic cells (Thyroid)': '0.019', 'Adrenal cortex cells': '0.698', 'Adrenal medulla cells': '0.062', 'Mitotic cells (Adrenal gland)': '0.450', 'Minor salivary glandular cells': '0.306', 'Minor salivary gland ductal cells': '-0.059', 'Minor salivary gland basal cells': '0.548', 'Mitotic cells (Minor salivary gland)': '0.595', 'Adipocytes (Minor salivary gland)': '0.141', 'Somatotropes': '0.087', 'Lactotropes': '0.080', 'Gonadotropes': '0.104', 'Corticotropes': '-0.100', 'Thyrotropes': '0.197', 'Undifferentiated cells (Pituitary gland)': '0.172', 'Mitotic cells (Spleen)': '-0.023', 'Platelets': '0.090', 'Erythrocytes': '-0.132', 'Hematopoietic stem cells': '0.013', 'B-cells (Spleen)': '-0.115', 'NK-cells (Spleen)': '0.041', 'Amygdala excitatory': '153.6', 'Cerebellar inhibitory': '221.3', 'Cge interneuron': '168.7', 'Deep-layer corticothalamic and 6b': '153.9', 'Deep-layer intratelencephalic': '155.9', 'Deep-layer near-projecting': '174.3', 'Eccentric medium spiny neuron': '185.9', 'Hippocampal ca1-3': '189.6', 'Hippocampal ca4': '170.4', 'Hippocampal dentate gyrus': '142.5', 'Lamp5-lhx6 and chandelier': '174.6', 'Lower rhombic lip': '220.9', 'Mammillary body': '257.0', 'Medium spiny neuron': '191.9', 'Mge interneuron': '185.0', 'Midbrain-derived inhibitory': '201.2', 'Miscellaneous': '182.4', 'Splatter': '182.0', 'Thalamic excitatory': '234.9', 'Upper rhombic lip': '188.6', 'Upper-layer intratelencephalic': '153.0', 'Astrocyte': '117.3', 'Bergmann glia': '103.6', 'Central nervous system macrophage': '215.7', 'Choroid plexus epithelial cell': '148.9', 'Committed oligodendrocyte precursor': '116.7', 'Ependymal cell': '106.7', 'Oligodendrocyte': '158.7', 'Oligodendrocyte precursor cell': '115.3', 'Endothelial cell': '176.7', 'Pericyte': '170.6', 'Vascular associated smooth muscle cell': '146.6', 'Fibroblast': '153.9', 'Leukocyte': '145.9', 'Basophil': '127.5', 'Eosinophil': '18.6', 'Neutrophil': '173.3', 'Classical monocyte': '69.1', 'Non-classical monocyte': '81.0', 'Intermediate monocyte': '136.0', 'T-reg': '73.8', 'GdT-cell': '15.7', 'MAIT T-cell': '86.1', 'Memory CD4 T-cell': '14.5', 'Naive CD4 T-cell': '52.4', 'Memory CD8 T-cell': '17.9', 'Naive CD8 T-cell': '43.5', 'Memory B-cell': '12.6', 'Naive B-cell': '66.1', 'Plasmacytoid DC': '207.7', 'Myeloid DC': '130.8', 'NK-cell': '66.7', 'Total PBMC': '98.2', 'Vd2 gdTCR': '75.4', 'Memory CD4 T-cell Th1\\/Th17': '64.2', 'Memory CD4 T-cell Th17': '60.7', 'Memory CD4 T-cell Th2': '63.0', 'Non-Vd2 gdTCR': '85.9', 'Memory CD4 T-cell Th1': '56.1', 'Memory CD4 T-cell TFH': '50.9', 'Terminal effector memory CD4 T-cell': '101.5', 'Central memory CD8 T-cell': '73.8', 'Effector memory CD8 T-cell': '90.1', 'Terminal effector memory CD8 T-cell': '86.0', 'Non-switched memory B-cell': '74.6', 'Plasmablast': '182.8', 'Switched memory B-cell': '70.5', 'Exhausted memory B-cell': '80.2', 'Progenitor cell': '91.1', 'Memory T-reg': '53.9', 'Naive CD4 T-cell activated': '108.1', 'Naive CD8 T-cell activated': '89.2', 'Naive T-reg': '52.6'}
2XZG, 4G55, 6E4L, 6QNN, 6QNP, 7BN1, 7BN2, 7ZX4
{'Adipose Tissue': 73.30917109634551, 'Adrenal Gland': 84.18348837209302, 'Bladder': 77.90761904761905, 'Blood': 47.360672766415504, 'Blood Vessel': 102.54850936329588, 'Brain': 70.06958743376231, 'Breast': 64.31806100217865, 'Cervix Uteri': 77.66736842105263, 'Colon': 67.74332477535302, 'Esophagus': 64.74337024221454, 'Fallopian Tube': 75.11222222222221, 'Heart': 29.45933217189315, 'Kidney': 48.126516853932586, 'Liver': 33.88464601769912, 'Lung': 84.00586505190311, 'Muscle': 30.696316313823164, 'Nerve': 80.48709208400646, 'Ovary': 68.84511111111111, 'Pancreas': 23.153368902439027, 'Pituitary': 78.003074204947, 'Prostate': 61.329346938775515, 'Salivary Gland': 58.11617283950617, 'Skin': 97.62664455500276, 'Small Intestine': 59.3907486631016, 'Spleen': 58.941327800829875, 'Stomach': 53.49284122562674, 'Testis': 58.79238227146814, 'Thyroid': 83.41173047473201, 'Uterus': 80.35669014084507, 'Vagina': 69.93070512820513}
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0.4, 0.29, 0.12, 0.47, 0.31, 0.14, 0.13, 0.9, 0.69, 0.37, 0.66, 0.84, 0.47, 0.1, 0.48, 0.48, 0.22, 0.18, 0.7, 0.73, 0.26, 0.85, 0.72, 0.25, 0.5, 0.34, 0.62, 0.51, 0.1, 0.0, 0.49, 0.28, 0.06, 0.22, 0.72, 0.31, 0.7, 0.29, 0.36, 0.72, 0.24, 0.0, 0.19, 0.53, 0.17, 0.25, 0.7, 0.86, 0.75, 0.83, 0.39, 0.62, 0.55, 0.22, 0.19, 0.08, 0.46, 0.02, 0.14, 0.16, 0.64, 0.32, 0.4, 0.33, 0.4, 0.12, 0.69, 0.57, 0.07, 0.36, 0.64, 0.33, 0.0, 0.58, 0.88, 0.43, 0.65, 0.59, 0.64, 0.59, 0.13, 0.12, 0.2, 0.35, 0.02, 0.0, 0.38, 0.03, 0.04, 0.12, 0.66, 0.52, 0.56, 0.35, 0.03, 0.59, 0.5, 0.0, 0.03, 0.48, 0.05, 0.0, 0.43, 0.68, 0.25, 0.5, 0.26, 0.25, 0.62, 0.16, 0.18, 0.59, 0.3, 0.0, 0.0, 0.61, 0.12, 0.0, 0.27, 0.84, 0.42, 0.46, 0.31, 0.14, 0.7, 0.34, 0.0, 0.11, 0.61, 0.0, 0.01, 0.51, 0.25, 0.01, 0.38, 0.86, 0.56, 0.28, 0.77, 0.41, 0.26, 0.32, 0.03, 0.05, 0.07, 0.09, 0.07, 0.0, 0.02, 0.0, 0.07, 0.08, 0.27, 0.31, 0.7, 0.43, 0.33, 0.69, 0.47, 0.01, 0.5, 0.75, 0.15, 0.1, 0.71, 0.38, 0.92, 0.29, 0.58, 0.15, 0.49, 0.1, 0.45, 0.59, 0.02, 0.0, 0.24, 0.3, 0.0, 0.13, 0.77, 0.54, 0.7, 0.26, 0.19, 0.59, 0.05, 0.0, 0.31, 0.37, 0.0, 0.0, 0.65, 0.47, 0.33, 0.51, 0.24, 0.29, 0.21, 0.38, 0.1, 0.01, 0.15, 0.0, 0.06, 0.2, 0.51, 0.32, 0.47, 0.38, 0.25, 0.55, 0.34, 0.0, 0.0, 0.42, 0.05, 0.0, 0.54, 0.63, 0.33, 0.74, 0.38, 0.27, 0.71, 0.11, 0.03, 0.19, 0.36, 0.01, 0.0, 0.13, 0.18, 0.0, 0.0, 0.55, 0.38, 0.63, 0.45, 0.22, 0.86, 0.13, 0.0, 0.3, 0.33, 0.0, 0.0, 0.24, 0.47, 0.02, 0.0, 0.21, 0.4, 0.5, 0.91, 0.3, 0.04, 0.71, 0.48, 0.01, 0.04, 0.42, 0.18, 0.02, 0.27, 0.84, 0.4, 0.45, 0.25, 0.27, 0.55, 0.41, 0.0, 0.0, 0.41, 0.01, 0.0, 0.32, 0.41, 0.0, 0.19, 0.8, 0.36, 0.97, 0.67, 0.12, 0.23, 0.49, 0.27, 0.0, 0.0, 0.04, 0.18, 0.0, 0.01, 0.11, 0.01, 0.06, 0.05, 0.69, 0.41, 0.17, 0.37, 0.81, 0.35, 0.0, 0.34, 0.65, 0.05, 0.0, 0.51, 0.73, 0.33, 0.37, 0.84, 0.42, 0.06, 0.4, 0.11, 0.37, 0.43, 0.0, 0.06, 0.61, 0.11, 0.0, 0.49, 0.75, 0.35, 0.6, 0.14, 0.17, 0.36, 0.15, 0.02, 0.01, 0.13, 0.0, 0.12, 0.24, 0.42, 0.45, 0.66, 0.34, 0.18, 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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
77.856782
0.345624
155
O60260
Q04837
33082525
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
SSBP1
MFRRPVLQVLRQFVRHESETTTSLVLERSLNRVHLLGRVGQDPVLRQVEGKNPVTIFSLATNEMWRSGDSEVYQLGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYLEGKIDYGEYMDKNNVRRQATTIIADNIIFLSDQTKEKE
Homo sapiens
Mitochondrion, Mitochondrion matrix, mitochondrion nucleoid
Low tissue specificity
{'Ciliated cells': '173.2', 'Basal respiratory cells': '473.2', 'Club cells': '187.2', 'Ionocytes': '268.0', 'Mucus glandular cells': '102.8', 'Serous glandular cells': '106.3', 'Gastric mucus-secreting cells': '92.0', 'Proximal enterocytes': '141.2', 'Paneth cells': '112.4', 'Distal enterocytes': '98.1', 'Intestinal goblet cells': '120.7', 'Exocrine glandular cells': '-0.764', 'Basal prostatic cells': '135.9', 'Prostatic glandular cells': '74.7', 'Breast glandular cells': '0.200', 'Breast myoepithelial cells': '0.032', 'Glandular and luminal cells': '187.4', 'Secretory cells': '246.0', 'Basal keratinocytes': '181.2', 'Suprabasal keratinocytes': '244.7', 'Basal squamous epithelial cells': '105.9', 'Squamous epithelial cells': '134.6', 'Alveolar cells type 1': '-0.150', 'Alveolar cells type 2': '0.321', 'Salivary duct cells': '97.6', 'Ductal cells': '0.533', 'Hepatocytes': '0.489', 'Cholangiocytes': '141.2', 'Proximal tubular cells': '0.289', 'Distal tubular cells': '248.9', 'Collecting duct cells': '138.1', 'Mesothelial cells': '0.101', 'Sertoli cells': '-0.083', 'Granulosa cells': '192.8', 'Enteroendocrine cells': '124.4', 'Pancreatic endocrine cells': '324.3', 'Leydig cells': '-0.030', 'Excitatory neurons': '16.4', 'Inhibitory neurons': '15.3', 'Cone photoreceptor cells': '96.9', 'Rod photoreceptor cells': '63.8', 'Bipolar cells': '57.0', 'Horizontal cells': '38.4', 'Astrocytes': '13.0', 'Oligodendrocyte precursor cells': '15.6', 'Oligodendrocytes': '27.1', 'Microglial cells': '14.3', 'Muller glia cells': '138.3', 'Schwann cells': '0.071', 'Spermatogonia': '0.187', 'Spermatocytes': '0.311', 'Early spermatids': '0.559', 'Late spermatids': '0.129', 'Oocytes': '301.4', 'Cytotrophoblasts': '342.9', 'Syncytiotrophoblasts': '262.4', 'Extravillous trophoblasts': '322.7', 'Endothelial cells': '145.1', 'Lymphatic endothelial cells': '128.2', 'Cardiomyocytes': '0.686', 'Skeletal myocytes': '-0.239', 'Smooth muscle cells': '155.5', 'Adipocytes': '138.2', 'Melanocytes': '0.264', 'Fibroblasts': '141.6', 'Peritubular cells': '-0.051', 'Endometrial stromal cells': '167.6', 'Ovarian stromal cells': '193.9', 'Undifferentiated cells': '201.2', 'T-cells': '138.9', 'B-cells': '120.1', 'Plasma cells': '138.5', 'Nk-cells': '139.5', 'Granulocytes': '219.8', 'Monocytes': '98.4', 'Macrophages': '130.7', 'Hofbauer cells': '258.8', 'Kupffer cells': '113.5', 'Dendritic cells': '112.1', 'Langerhans cells': '0.186', 'Erythroid cells': '-0.069', 'Adipocytes (Subcutaneous)': '-0.033', 'Adipocytes (Visceral)': '0.102', 'Breast glandular cells (progenitors)': '0.042', 'Adipocytes (Breast)': '-0.059', 'Colon enterocytes': '-0.186', 'Colon enteroendocrine cells': '0.205', 'Enteric glia cells': '-0.243', 'Mitotic cells (Colon)': '-0.139', 'Mitotic cells (Heart)': '0.497', 'Podocytes': '0.041', 'Ascending Loop of Henle cells': '0.318', 'Intercalated cells': '0.074', 'Cholangiocyte': '0.330', 'NK-cells (Liver)': '-0.411', 'Respiratory ciliated cells': '-0.091', 'Mitotic cells (Lung)': '0.254', 'NK-cells (Lung)': '-0.353', 'B-cells (Lung)': '-0.309', 'Alpha cells': '0.324', 'Beta cells': '0.134', 'Prostate glandular cells': '-0.268', 'Prostate basal glandular cells': '0.046', 'Urothelial cells': '0.026', 'Keratinocyte (other)': '0.011', 'Keratinocyte (granular)': '-0.238', 'Hair cortex cells': '0.220', 'Inner root sheath cells': '0.323', 'Outer root sheath cells': '0.256', 'Sebaceous gland cells': '0.249', 'Eccrine sweat gland cells': '0.022', 'Adipocytes (Skin)': '0.041', 'Mitotic cells (Skin)': '0.325', 'Parietal cells': '-0.558', 'Chief cells': '-0.484', 'Gastric mucous cells': '-0.228', 'Gastric enteroendocrine cells': '-0.397', 'Mitotic cells (Stomach)': '0.231', 'Parafollicular cells': '0.085', 'Thyroid glandular cells': '0.309', 'Mitotic cells (Thyroid)': '-0.068', 'Adrenal cortex cells': '0.378', 'Adrenal medulla cells': '0.080', 'Mitotic cells (Adrenal gland)': '0.322', 'Minor salivary glandular cells': '0.384', 'Minor salivary gland ductal cells': '-0.230', 'Minor salivary gland basal cells': '0.619', 'Mitotic cells (Minor salivary gland)': '0.708', 'Adipocytes (Minor salivary gland)': '0.242', 'Somatotropes': '-0.120', 'Lactotropes': '-0.180', 'Gonadotropes': '-0.174', 'Corticotropes': '0.044', 'Thyrotropes': '0.142', 'Undifferentiated cells (Pituitary gland)': '0.209', 'Mitotic cells (Spleen)': '-0.003', 'Platelets': '-0.056', 'Erythrocytes': '-0.148', 'Hematopoietic stem cells': '0.036', 'B-cells (Spleen)': '0.145', 'NK-cells (Spleen)': '-0.064', 'Amygdala excitatory': '47.2', 'Cerebellar inhibitory': '52.5', 'Cge interneuron': '50.7', 'Deep-layer corticothalamic and 6b': '60.3', 'Deep-layer intratelencephalic': '48.0', 'Deep-layer near-projecting': '68.3', 'Eccentric medium spiny neuron': '57.1', 'Hippocampal ca1-3': '49.3', 'Hippocampal ca4': '78.2', 'Hippocampal dentate gyrus': '65.1', 'Lamp5-lhx6 and chandelier': '46.7', 'Lower rhombic lip': '53.8', 'Mammillary body': '51.6', 'Medium spiny neuron': '56.8', 'Mge interneuron': '50.1', 'Midbrain-derived inhibitory': '51.6', 'Miscellaneous': '50.7', 'Splatter': '54.6', 'Thalamic excitatory': '50.6', 'Upper rhombic lip': '63.4', 'Upper-layer intratelencephalic': '51.3', 'Astrocyte': '61.4', 'Bergmann glia': '63.8', 'Central nervous system macrophage': '87.3', 'Choroid plexus epithelial cell': '50.6', 'Committed oligodendrocyte precursor': '59.1', 'Ependymal cell': '46.9', 'Oligodendrocyte': '82.1', 'Oligodendrocyte precursor cell': '60.8', 'Endothelial cell': '67.3', 'Pericyte': '69.8', 'Vascular associated smooth muscle cell': '63.4', 'Fibroblast': '58.6', 'Leukocyte': '59.8', 'Basophil': '58.4', 'Eosinophil': '77.0', 'Neutrophil': '16.4', 'Classical monocyte': '39.2', 'Non-classical monocyte': '48.2', 'Intermediate monocyte': '76.8', 'T-reg': '94.5', 'GdT-cell': '71.9', 'MAIT T-cell': '76.5', 'Memory CD4 T-cell': '114.2', 'Naive CD4 T-cell': '98.7', 'Memory CD8 T-cell': '98.9', 'Naive CD8 T-cell': '90.0', 'Memory B-cell': '106.7', 'Naive B-cell': '84.6', 'Plasmacytoid DC': '73.9', 'Myeloid DC': '87.0', 'NK-cell': '75.7', 'Total PBMC': '82.7', 'Vd2 gdTCR': '98.3', 'Memory CD4 T-cell Th1\\/Th17': '77.9', 'Memory CD4 T-cell Th17': '74.6', 'Memory CD4 T-cell Th2': '78.5', 'Non-Vd2 gdTCR': '77.1', 'Memory CD4 T-cell Th1': '70.5', 'Memory CD4 T-cell TFH': '78.7', 'Terminal effector memory CD4 T-cell': '56.0', 'Central memory CD8 T-cell': '71.5', 'Effector memory CD8 T-cell': '53.5', 'Terminal effector memory CD8 T-cell': '82.3', 'Non-switched memory B-cell': '62.8', 'Plasmablast': '95.1', 'Switched memory B-cell': '60.7', 'Exhausted memory B-cell': '104.6', 'Progenitor cell': '66.9', 'Memory T-reg': '65.8', 'Naive CD4 T-cell activated': '99.1', 'Naive CD8 T-cell activated': '120.3', 'Naive T-reg': '88.8'}
1S3O, 2DUD, 3ULL, 6RUP
{'Adipose Tissue': 59.58157059800664, 'Adrenal Gland': 59.760852713178295, 'Bladder': 63.07714285714285, 'Blood': 43.981525296017224, 'Blood Vessel': 78.37505617977529, 'Brain': 34.12708137774413, 'Breast': 62.8433551198257, 'Cervix Uteri': 65.16947368421053, 'Colon': 59.820551989730426, 'Esophagus': 66.62318339100347, 'Fallopian Tube': 68.47555555555556, 'Heart': 38.79480603948897, 'Kidney': 40.83640449438202, 'Liver': 32.46816371681416, 'Lung': 54.66140138408305, 'Muscle': 43.3792403486924, 'Nerve': 68.4419547657512, 'Ovary': 74.16588888888889, 'Pancreas': 24.348085365853656, 'Pituitary': 50.89208480565371, 'Prostate': 49.46310204081632, 'Salivary Gland': 49.90561728395062, 'Skin': 78.99762299613046, 'Small Intestine': 52.510855614973266, 'Spleen': 55.13780082987552, 'Stomach': 50.78632311977716, 'Testis': 78.25764542936288, 'Thyroid': 61.01422664624809, 'Uterus': 73.94640845070423, 'Vagina': 65.52666666666667}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
83.715946
0.530743
2,893
O60260
Q07812
22460798, 23503661
UbiNet, UbiBrowser, DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
BAX
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
Homo sapiens
Mitochondrion outer membrane, Cytoplasm, Nucleus, Cytoplasm, Cytoplasm, Cytoplasm
Low tissue specificity
{'Ciliated cells': '72.2', 'Basal respiratory cells': '159.1', 'Club cells': '104.6', 'Ionocytes': '153.9', 'Mucus glandular cells': '35.1', 'Serous glandular cells': '31.5', 'Gastric mucus-secreting cells': '118.5', 'Proximal enterocytes': '225.1', 'Paneth cells': '169.5', 'Distal enterocytes': '164.9', 'Intestinal goblet cells': '94.1', 'Exocrine glandular cells': '-0.564', 'Basal prostatic cells': '41.5', 'Prostatic glandular cells': '64.9', 'Breast glandular cells': '0.420', 'Breast myoepithelial cells': '0.308', 'Glandular and luminal cells': '52.4', 'Secretory cells': '174.2', 'Basal keratinocytes': '52.6', 'Suprabasal keratinocytes': '58.4', 'Basal squamous epithelial cells': '99.1', 'Squamous epithelial cells': '85.5', 'Alveolar cells type 1': '-0.268', 'Alveolar cells type 2': '0.062', 'Salivary duct cells': '32.3', 'Ductal cells': '0.434', 'Hepatocytes': '0.309', 'Cholangiocytes': '64.9', 'Proximal tubular cells': '0.347', 'Distal tubular cells': '70.7', 'Collecting duct cells': '72.0', 'Mesothelial cells': '0.253', 'Sertoli cells': '0.588', 'Granulosa cells': '44.9', 'Enteroendocrine cells': '120.8', 'Pancreatic endocrine cells': '157.9', 'Leydig cells': '0.637', 'Excitatory neurons': '7.7', 'Inhibitory neurons': '7.9', 'Cone photoreceptor cells': '27.2', 'Rod photoreceptor cells': '15.2', 'Bipolar cells': '21.1', 'Horizontal cells': '18.9', 'Astrocytes': '7.7', 'Oligodendrocyte precursor cells': '7.1', 'Oligodendrocytes': '12.9', 'Microglial cells': '3.6', 'Muller glia cells': '49.7', 'Schwann cells': '-0.013', 'Spermatogonia': '0.454', 'Spermatocytes': '-0.013', 'Early spermatids': '-0.643', 'Late spermatids': '-0.627', 'Oocytes': '15.4', 'Cytotrophoblasts': '131.7', 'Syncytiotrophoblasts': '98.0', 'Extravillous trophoblasts': '165.7', 'Endothelial cells': '76.0', 'Lymphatic endothelial cells': '78.6', 'Cardiomyocytes': '0.300', 'Skeletal myocytes': '-0.292', 'Smooth muscle cells': '58.2', 'Adipocytes': '81.1', 'Melanocytes': '0.149', 'Fibroblasts': '61.9', 'Peritubular cells': '0.517', 'Endometrial stromal cells': '67.7', 'Ovarian stromal cells': '41.9', 'Undifferentiated cells': '138.7', 'T-cells': '146.7', 'B-cells': '152.9', 'Plasma cells': '94.4', 'Nk-cells': '120.6', 'Granulocytes': '112.2', 'Monocytes': '142.0', 'Macrophages': '148.6', 'Hofbauer cells': '287.0', 'Kupffer cells': '107.0', 'Dendritic cells': '103.7', 'Langerhans cells': '0.143', 'Erythroid cells': '-0.010', 'Adipocytes (Subcutaneous)': '-0.440', 'Adipocytes (Visceral)': '-0.466', 'Breast glandular cells (progenitors)': '0.207', 'Adipocytes (Breast)': '-0.422', 'Colon enterocytes': '0.155', 'Colon enteroendocrine cells': '-0.109', 'Enteric glia cells': '0.059', 'Mitotic cells (Colon)': '0.273', 'Mitotic cells (Heart)': '0.515', 'Podocytes': '-0.097', 'Ascending Loop of Henle cells': '0.257', 'Intercalated cells': '-0.134', 'Cholangiocyte': '0.430', 'NK-cells (Liver)': '-0.309', 'Respiratory ciliated cells': '-0.156', 'Mitotic cells (Lung)': '0.287', 'NK-cells (Lung)': '-0.152', 'B-cells (Lung)': '-0.086', 'Alpha cells': '0.395', 'Beta cells': '0.286', 'Prostate glandular cells': '-0.025', 'Prostate basal glandular cells': '0.263', 'Urothelial cells': '0.261', 'Keratinocyte (other)': '0.105', 'Keratinocyte (granular)': '-0.134', 'Hair cortex cells': '0.022', 'Inner root sheath cells': '0.044', 'Outer root sheath cells': '0.115', 'Sebaceous gland cells': '-0.136', 'Eccrine sweat gland cells': '-0.216', 'Adipocytes (Skin)': '-0.166', 'Mitotic cells (Skin)': '0.155', 'Parietal cells': '-0.219', 'Chief cells': '-0.221', 'Gastric mucous cells': '0.293', 'Gastric enteroendocrine cells': '-0.046', 'Mitotic cells (Stomach)': '0.538', 'Parafollicular cells': '-0.046', 'Thyroid glandular cells': '0.132', 'Mitotic cells (Thyroid)': '0.091', 'Adrenal cortex cells': '0.298', 'Adrenal medulla cells': '-0.043', 'Mitotic cells (Adrenal gland)': '0.440', 'Minor salivary glandular cells': '0.628', 'Minor salivary gland ductal cells': '-0.086', 'Minor salivary gland basal cells': '0.388', 'Mitotic cells (Minor salivary gland)': '0.532', 'Adipocytes (Minor salivary gland)': '0.203', 'Somatotropes': '-0.157', 'Lactotropes': '-0.263', 'Gonadotropes': '-0.215', 'Corticotropes': '-0.200', 'Thyrotropes': '-0.060', 'Undifferentiated cells (Pituitary gland)': '0.295', 'Mitotic cells (Spleen)': '-0.298', 'Platelets': '-0.078', 'Erythrocytes': '-0.106', 'Hematopoietic stem cells': '-0.120', 'B-cells (Spleen)': '0.328', 'NK-cells (Spleen)': '0.130', 'Amygdala excitatory': '10.1', 'Cerebellar inhibitory': '11.8', 'Cge interneuron': '14.0', 'Deep-layer corticothalamic and 6b': '12.6', 'Deep-layer intratelencephalic': '12.1', 'Deep-layer near-projecting': '13.9', 'Eccentric medium spiny neuron': '10.4', 'Hippocampal ca1-3': '12.3', 'Hippocampal ca4': '14.7', 'Hippocampal dentate gyrus': '14.5', 'Lamp5-lhx6 and chandelier': '14.0', 'Lower rhombic lip': '12.2', 'Mammillary body': '9.2', 'Medium spiny neuron': '9.4', 'Mge interneuron': '13.0', 'Midbrain-derived inhibitory': '9.6', 'Miscellaneous': '15.5', 'Splatter': '10.4', 'Thalamic excitatory': '10.9', 'Upper rhombic lip': '10.1', 'Upper-layer intratelencephalic': '12.5', 'Astrocyte': '13.5', 'Bergmann glia': '12.3', 'Central nervous system macrophage': '50.0', 'Choroid plexus epithelial cell': '10.6', 'Committed oligodendrocyte precursor': '20.3', 'Ependymal cell': '13.0', 'Oligodendrocyte': '21.8', 'Oligodendrocyte precursor cell': '16.3', 'Endothelial cell': '23.0', 'Pericyte': '21.8', 'Vascular associated smooth muscle cell': '16.6', 'Fibroblast': '14.6', 'Leukocyte': '46.5', 'Basophil': '15.8', 'Eosinophil': '13.5', 'Neutrophil': '40.9', 'Classical monocyte': '71.9', 'Non-classical monocyte': '84.5', 'Intermediate monocyte': '39.4', 'T-reg': '16.8', 'GdT-cell': '6.6', 'MAIT T-cell': '14.0', 'Memory CD4 T-cell': '3.7', 'Naive CD4 T-cell': '46.8', 'Memory CD8 T-cell': '7.1', 'Naive CD8 T-cell': '69.2', 'Memory B-cell': '7.3', 'Naive B-cell': '46.5', 'Plasmacytoid DC': '21.0', 'Myeloid DC': '31.7', 'NK-cell': '93.9', 'Total PBMC': '27.8', 'Vd2 gdTCR': '18.9', 'Memory CD4 T-cell TFH': '81.5', 'Memory CD4 T-cell Th2': '66.7', 'Memory CD4 T-cell Th17': '67.3', 'Memory CD4 T-cell Th1\\/Th17': '58.9', 'Non-Vd2 gdTCR': '21.0', 'Memory CD4 T-cell Th1': '76.9', 'Terminal effector memory CD4 T-cell': '12.5', 'Central memory CD8 T-cell': '21.9', 'Effector memory CD8 T-cell': '18.7', 'Terminal effector memory CD8 T-cell': '25.8', 'Switched memory B-cell': '23.1', 'Plasmablast': '22.4', 'Non-switched memory B-cell': '19.9', 'Exhausted memory B-cell': '23.2', 'Progenitor cell': '11.0', 'Naive CD4 T-cell activated': '59.1', 'Naive CD8 T-cell activated': '79.3', 'Memory T-reg': '114.4', 'Naive T-reg': '61.7'}
1F16, 2G5B, 2K7W, 2LR1, 3PK1, 3PL7, 4BD2, 4BD6, 4BD7, 4BD8, 4BDU, 4S0O, 4S0P, 4UF2, 4ZIE, 4ZIF, 4ZIG, 4ZIH, 4ZII, 5W5X, 5W5Z, 5W60, 5W61, 6EB6, 6L8V, 6L95, 6TRR, 6XY6, 7ADT, 8G1T, 8SPE, 8SPF, 8SPZ, 8SRX, 8SRY, 8SVK
{'Adipose Tissue': 41.043089700996674, 'Adrenal Gland': 39.20142635658915, 'Bladder': 53.56, 'Blood': 99.83167491926804, 'Blood Vessel': 45.9063520599251, 'Brain': 18.394287282361848, 'Breast': 41.21084967320261, 'Cervix Uteri': 55.14052631578948, 'Colon': 47.23863928112966, 'Esophagus': 39.46728027681661, 'Fallopian Tube': 53.47444444444445, 'Heart': 14.287628339140534, 'Kidney': 33.17348314606742, 'Liver': 20.013986725663717, 'Lung': 84.04745674740485, 'Muscle': 11.807084682440848, 'Nerve': 49.01237479806139, 'Ovary': 39.66044444444445, 'Pancreas': 16.26005487804878, 'Pituitary': 40.023957597173144, 'Prostate': 50.83330612244898, 'Salivary Gland': 35.870555555555555, 'Skin': 80.40447208402432, 'Small Intestine': 78.85871657754011, 'Spleen': 123.25991701244811, 'Stomach': 34.63586072423398, 'Testis': 27.088304709141276, 'Thyroid': 53.948131699846854, 'Uterus': 53.5312676056338, 'Vagina': 46.18698717948718}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
87.02026
0.349375
2,766
O60260
Q07817
33431795
UbiBrowser
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
BCL2L1
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Homo sapiens
Mitochondrion inner membrane, Mitochondrion outer membrane, Mitochondrion matrix, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasm, cytosol, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus membrane
Low tissue specificity
{'Ciliated cells': '100.7', 'Basal respiratory cells': '46.5', 'Club cells': '62.2', 'Ionocytes': '67.7', 'Mucus glandular cells': '76.3', 'Serous glandular cells': '20.0', 'Gastric mucus-secreting cells': '36.6', 'Proximal enterocytes': '57.5', 'Paneth cells': '18.5', 'Distal enterocytes': '33.8', 'Intestinal goblet cells': '28.3', 'Exocrine glandular cells': '-0.600', 'Basal prostatic cells': '36.8', 'Prostatic glandular cells': '42.9', 'Breast glandular cells': '0.325', 'Breast myoepithelial cells': '-0.030', 'Glandular and luminal cells': '71.8', 'Secretory cells': '41.2', 'Basal keratinocytes': '20.8', 'Suprabasal keratinocytes': '20.8', 'Basal squamous epithelial cells': '22.4', 'Squamous epithelial cells': '14.9', 'Alveolar cells type 1': '0.247', 'Alveolar cells type 2': '0.350', 'Salivary duct cells': '49.3', 'Ductal cells': '0.659', 'Hepatocytes': '-0.062', 'Cholangiocytes': '110.7', 'Proximal tubular cells': '0.171', 'Distal tubular cells': '76.8', 'Collecting duct cells': '40.8', 'Mesothelial cells': '-0.097', 'Sertoli cells': '-0.377', 'Granulosa cells': '15.5', 'Enteroendocrine cells': '31.9', 'Pancreatic endocrine cells': '62.8', 'Leydig cells': '-0.404', 'Excitatory neurons': '21.1', 'Inhibitory neurons': '18.7', 'Cone photoreceptor cells': '98.6', 'Rod photoreceptor cells': '139.1', 'Bipolar cells': '55.2', 'Horizontal cells': '34.6', 'Astrocytes': '21.4', 'Oligodendrocyte precursor cells': '12.7', 'Oligodendrocytes': '51.7', 'Microglial cells': '47.4', 'Muller glia cells': '43.0', 'Schwann cells': '0.034', 'Spermatogonia': '-0.201', 'Spermatocytes': '0.153', 'Early spermatids': '0.605', 'Late spermatids': '0.351', 'Oocytes': '12.5', 'Cytotrophoblasts': '29.5', 'Syncytiotrophoblasts': '27.5', 'Extravillous trophoblasts': '13.4', 'Endothelial cells': '52.1', 'Lymphatic endothelial cells': '44.6', 'Cardiomyocytes': '0.404', 'Skeletal myocytes': '-0.336', 'Smooth muscle cells': '36.2', 'Adipocytes': '50.9', 'Melanocytes': '-0.083', 'Fibroblasts': '21.1', 'Peritubular cells': '-0.287', 'Endometrial stromal cells': '21.6', 'Ovarian stromal cells': '13.2', 'Undifferentiated cells': '29.2', 'T-cells': '31.7', 'B-cells': '12.2', 'Plasma cells': '47.3', 'Nk-cells': '48.4', 'Granulocytes': '45.0', 'Monocytes': '12.8', 'Macrophages': '27.2', 'Hofbauer cells': '38.0', 'Kupffer cells': '22.5', 'Dendritic cells': '7.4', 'Langerhans cells': '-0.329', 'Erythroid cells': '0.000', 'Adipocytes (Subcutaneous)': '0.122', 'Adipocytes (Visceral)': '-0.055', 'Breast glandular cells (progenitors)': '0.093', 'Adipocytes (Breast)': '-0.152', 'Colon enterocytes': '-0.001', 'Colon enteroendocrine cells': '0.199', 'Enteric glia cells': '0.031', 'Mitotic cells (Colon)': '-0.047', 'Mitotic cells (Heart)': '0.448', 'Podocytes': '0.021', 'Ascending Loop of Henle cells': '0.331', 'Intercalated cells': '0.033', 'Cholangiocyte': '0.281', 'NK-cells (Liver)': '-0.240', 'Respiratory ciliated cells': '-0.041', 'Mitotic cells (Lung)': '-0.006', 'NK-cells (Lung)': '-0.205', 'B-cells (Lung)': '-0.268', 'Alpha cells': '0.441', 'Beta cells': '0.256', 'Prostate glandular cells': '0.374', 'Prostate basal glandular cells': '0.443', 'Urothelial cells': '0.179', 'Keratinocyte (other)': '-0.459', 'Keratinocyte (granular)': '-0.092', 'Hair cortex cells': '0.427', 'Inner root sheath cells': '0.388', 'Outer root sheath cells': '0.255', 'Sebaceous gland cells': '0.003', 'Eccrine sweat gland cells': '0.405', 'Adipocytes (Skin)': '0.437', 'Mitotic cells (Skin)': '0.022', 'Parietal cells': '0.233', 'Chief cells': '0.394', 'Gastric mucous cells': '0.339', 'Gastric enteroendocrine cells': '0.398', 'Mitotic cells (Stomach)': '0.250', 'Parafollicular cells': '0.007', 'Thyroid glandular cells': '0.622', 'Mitotic cells (Thyroid)': '-0.137', 'Adrenal cortex cells': '0.215', 'Adrenal medulla cells': '-0.105', 'Mitotic cells (Adrenal gland)': '-0.056', 'Minor salivary glandular cells': '0.776', 'Minor salivary gland ductal cells': '0.106', 'Minor salivary gland basal cells': '0.179', 'Mitotic cells (Minor salivary gland)': '0.244', 'Adipocytes (Minor salivary gland)': '0.185', 'Somatotropes': '-0.318', 'Lactotropes': '-0.319', 'Gonadotropes': '-0.207', 'Corticotropes': '0.205', 'Thyrotropes': '0.057', 'Undifferentiated cells (Pituitary gland)': '0.270', 'Mitotic cells (Spleen)': '0.152', 'Platelets': '0.192', 'Erythrocytes': '0.471', 'Hematopoietic stem cells': '0.095', 'B-cells (Spleen)': '-0.198', 'NK-cells (Spleen)': '0.058', 'Amygdala excitatory': '40.8', 'Cerebellar inhibitory': '35.0', 'Cge interneuron': '32.4', 'Deep-layer corticothalamic and 6b': '43.6', 'Deep-layer intratelencephalic': '50.0', 'Deep-layer near-projecting': '42.4', 'Eccentric medium spiny neuron': '35.7', 'Hippocampal ca1-3': '34.0', 'Hippocampal ca4': '35.5', 'Hippocampal dentate gyrus': '34.2', 'Lamp5-lhx6 and chandelier': '33.5', 'Lower rhombic lip': '42.1', 'Mammillary body': '39.5', 'Medium spiny neuron': '39.5', 'Mge interneuron': '43.4', 'Midbrain-derived inhibitory': '27.0', 'Miscellaneous': '40.2', 'Splatter': '32.4', 'Thalamic excitatory': '35.7', 'Upper rhombic lip': '64.9', 'Upper-layer intratelencephalic': '42.8', 'Astrocyte': '46.5', 'Bergmann glia': '39.3', 'Central nervous system macrophage': '116.7', 'Choroid plexus epithelial cell': '299.6', 'Committed oligodendrocyte precursor': '69.2', 'Ependymal cell': '62.2', 'Oligodendrocyte': '126.2', 'Oligodendrocyte precursor cell': '33.1', 'Endothelial cell': '201.1', 'Pericyte': '121.1', 'Vascular associated smooth muscle cell': '59.3', 'Fibroblast': '92.4', 'Leukocyte': '90.9', 'Basophil': '72.8', 'Eosinophil': '25.7', 'Neutrophil': '48.0', 'Classical monocyte': '13.7', 'Non-classical monocyte': '15.9', 'Intermediate monocyte': '42.7', 'T-reg': '31.4', 'GdT-cell': '40.0', 'MAIT T-cell': '86.6', 'Memory CD4 T-cell': '17.2', 'Naive CD4 T-cell': '9.1', 'Memory CD8 T-cell': '26.8', 'Naive CD8 T-cell': '9.5', 'Memory B-cell': '4.8', 'Naive B-cell': '4.8', 'Plasmacytoid DC': '27.7', 'Myeloid DC': '29.3', 'NK-cell': '72.4', 'Total PBMC': '105.7', 'Vd2 gdTCR': '72.1', 'Memory CD4 T-cell Th1\\/Th17': '20.2', 'Memory CD4 T-cell Th17': '21.8', 'Memory CD4 T-cell Th2': '16.8', 'Non-Vd2 gdTCR': '106.8', 'Memory CD4 T-cell Th1': '22.6', 'Memory CD4 T-cell TFH': '20.4', 'Terminal effector memory CD4 T-cell': '100.9', 'Central memory CD8 T-cell': '40.8', 'Effector memory CD8 T-cell': '82.6', 'Terminal effector memory CD8 T-cell': '96.4', 'Non-switched memory B-cell': '91.6', 'Plasmablast': '69.0', 'Switched memory B-cell': '62.2', 'Exhausted memory B-cell': '92.3', 'Progenitor cell': '75.1', 'Memory T-reg': '30.2', 'Naive CD4 T-cell activated': '256.6', 'Naive CD8 T-cell activated': '174.7', 'Naive T-reg': '10.7'}
1BXL, 1G5J, 1LXL, 1MAZ, 1R2D, 1R2E, 1R2G, 1R2H, 1R2I, 1YSG, 1YSI, 1YSN, 2B48, 2LP8, 2LPC, 2M03, 2M04, 2ME8, 2ME9, 2MEJ, 2O1Y, 2O2M, 2O2N, 2P1L, 2PON, 2YJ1, 2YQ6, 2YQ7, 2YXJ, 3CVA, 3FDL, 3FDM, 3INQ, 3IO8, 3PL7, 3QKD, 3R85, 3SP7, 3SPF, 3WIZ, 3ZK6, 3ZLN, 3ZLO, 3ZLR, 4A1U, 4A1W, 4AQ3, 4BPK, 4C52, 4C5D, 4CIN, 4EHR, 4HNJ, 4IEH, 4PPI, 4QVE, 4QVF, 4QVX, 4TUH, 4Z9V, 5AGW, 5AGX, 5B1Z, 5C3G, 5FMJ, 5FMK, 5VAY, 5VX3, 6BF2, 6DCN, 6DCO, 6F46, 6HJL, 6IJQ, 6LHD, 6O0K, 6O0L, 6O0M, 6O0O, 6O0P, 6RNU, 6ST2, 6UVC, 6UVD, 6UVE, 6UVF, 6UVG, 6UVH, 6VWC, 6X7I, 6YLI, 6ZHC, 7CA4, 7JGV, 7JGW, 7LH7, 7XGF, 7XGG, 7Y8D, 7YAA, 8FY0, 8IQK, 8IQL, 8U27, 8WLS, 8XP5
{'Adipose Tissue': 117.6935880398671, 'Adrenal Gland': 61.7718992248062, 'Bladder': 78.00238095238095, 'Blood': 192.40328310010764, 'Blood Vessel': 165.6310786516854, 'Brain': 67.96056775170325, 'Breast': 120.6975163398693, 'Cervix Uteri': 86.48684210526316, 'Colon': 63.80378690629012, 'Esophagus': 98.4996124567474, 'Fallopian Tube': 86.74333333333334, 'Heart': 42.389462253193955, 'Kidney': 106.72337078651684, 'Liver': 64.20840707964602, 'Lung': 191.7938581314879, 'Muscle': 40.859618929016186, 'Nerve': 158.15444264943457, 'Ovary': 45.813166666666675, 'Pancreas': 37.43180487804878, 'Pituitary': 99.9173851590106, 'Prostate': 105.72077551020408, 'Salivary Gland': 106.60870370370372, 'Skin': 117.28174682144832, 'Small Intestine': 73.00422459893049, 'Spleen': 95.04921161825726, 'Stomach': 81.33367688022284, 'Testis': 108.02847645429362, 'Thyroid': 112.1490964777948, 'Uterus': 74.5911971830986, 'Vagina': 98.91942307692308}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
72.758283
0.474077
2,596
O60260
Q07820
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
MCL1
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Homo sapiens
Membrane, Cytoplasm, Mitochondrion, Nucleus, nucleoplasm
Tissue enhanced (bone)
{'Ciliated cells': '155.7', 'Basal respiratory cells': '139.9', 'Club cells': '201.5', 'Ionocytes': '134.7', 'Mucus glandular cells': '361.3', 'Serous glandular cells': '187.2', 'Gastric mucus-secreting cells': '212.2', 'Proximal enterocytes': '215.8', 'Paneth cells': '149.9', 'Distal enterocytes': '316.1', 'Intestinal goblet cells': '270.1', 'Exocrine glandular cells': '-0.670', 'Basal prostatic cells': '317.8', 'Prostatic glandular cells': '82.7', 'Breast glandular cells': '0.457', 'Breast myoepithelial cells': '0.594', 'Glandular and luminal cells': '352.7', 'Secretory cells': '198.7', 'Basal keratinocytes': '375.5', 'Suprabasal keratinocytes': '443.7', 'Basal squamous epithelial cells': '393.8', 'Squamous epithelial cells': '351.8', 'Alveolar cells type 1': '0.142', 'Alveolar cells type 2': '0.031', 'Salivary duct cells': '371.2', 'Ductal cells': '0.640', 'Hepatocytes': '0.175', 'Cholangiocytes': '221.3', 'Proximal tubular cells': '0.248', 'Distal tubular cells': '27.7', 'Collecting duct cells': '37.0', 'Mesothelial cells': '-0.075', 'Sertoli cells': '0.344', 'Granulosa cells': '411.0', 'Enteroendocrine cells': '199.5', 'Pancreatic endocrine cells': '47.5', 'Leydig cells': '0.522', 'Excitatory neurons': '6.3', 'Inhibitory neurons': '5.2', 'Cone photoreceptor cells': '52.7', 'Rod photoreceptor cells': '93.5', 'Bipolar cells': '48.7', 'Horizontal cells': '35.9', 'Astrocytes': '11.8', 'Oligodendrocyte precursor cells': '9.4', 'Oligodendrocytes': '6.4', 'Microglial cells': '28.6', 'Muller glia cells': '130.5', 'Schwann cells': '0.111', 'Spermatogonia': '0.466', 'Spermatocytes': '0.199', 'Early spermatids': '-0.204', 'Late spermatids': '-0.444', 'Oocytes': '18.4', 'Cytotrophoblasts': '110.3', 'Syncytiotrophoblasts': '309.7', 'Extravillous trophoblasts': '217.3', 'Endothelial cells': '237.3', 'Lymphatic endothelial cells': '312.8', 'Cardiomyocytes': '0.237', 'Skeletal myocytes': '-0.230', 'Smooth muscle cells': '231.1', 'Adipocytes': '365.2', 'Melanocytes': '0.133', 'Fibroblasts': '292.6', 'Peritubular cells': '0.423', 'Endometrial stromal cells': '318.3', 'Ovarian stromal cells': '152.0', 'Undifferentiated cells': '135.6', 'T-cells': '498.2', 'B-cells': '316.5', 'Plasma cells': '716.2', 'Nk-cells': '393.9', 'Granulocytes': '843.2', 'Monocytes': '1334.1', 'Macrophages': '727.7', 'Hofbauer cells': '487.7', 'Kupffer cells': '411.9', 'Dendritic cells': '726.8', 'Langerhans cells': '0.006', 'Erythroid cells': '0.014', 'Adipocytes (Subcutaneous)': '-0.388', 'Adipocytes (Visceral)': '0.157', 'Breast glandular cells (progenitors)': '0.400', 'Adipocytes (Breast)': '-0.643', 'Colon enterocytes': '-0.008', 'Colon enteroendocrine cells': '0.133', 'Enteric glia cells': '-0.203', 'Mitotic cells (Colon)': '0.158', 'Mitotic cells (Heart)': '0.386', 'Podocytes': '0.027', 'Ascending Loop of Henle cells': '0.144', 'Intercalated cells': '-0.056', 'Cholangiocyte': '0.381', 'NK-cells (Liver)': '-0.274', 'Respiratory ciliated cells': '0.005', 'Mitotic cells (Lung)': '-0.088', 'NK-cells (Lung)': '0.111', 'B-cells (Lung)': '0.107', 'Alpha cells': '0.282', 'Beta cells': '0.166', 'Prostate glandular cells': '-0.369', 'Prostate basal glandular cells': '0.058', 'Urothelial cells': '0.208', 'Keratinocyte (other)': '0.165', 'Keratinocyte (granular)': '-0.059', 'Hair cortex cells': '-0.184', 'Inner root sheath cells': '-0.122', 'Outer root sheath cells': '-0.076', 'Sebaceous gland cells': '-0.116', 'Eccrine sweat gland cells': '-0.033', 'Adipocytes (Skin)': '-0.155', 'Mitotic cells (Skin)': '0.099', 'Parietal cells': '-0.551', 'Chief cells': '-0.486', 'Gastric mucous cells': '-0.321', 'Gastric enteroendocrine cells': '-0.369', 'Mitotic cells (Stomach)': '-0.029', 'Parafollicular cells': '0.016', 'Thyroid glandular cells': '0.007', 'Mitotic cells (Thyroid)': '0.119', 'Adrenal cortex cells': '0.176', 'Adrenal medulla cells': '-0.019', 'Mitotic cells (Adrenal gland)': '0.093', 'Minor salivary glandular cells': '0.636', 'Minor salivary gland ductal cells': '0.048', 'Minor salivary gland basal cells': '0.401', 'Mitotic cells (Minor salivary gland)': '0.462', 'Adipocytes (Minor salivary gland)': '0.231', 'Somatotropes': '-0.347', 'Lactotropes': '-0.410', 'Gonadotropes': '-0.039', 'Corticotropes': '-0.114', 'Thyrotropes': '-0.067', 'Undifferentiated cells (Pituitary gland)': '0.204', 'Mitotic cells (Spleen)': '0.088', 'Platelets': '0.156', 'Erythrocytes': '-0.043', 'Hematopoietic stem cells': '0.013', 'B-cells (Spleen)': '0.101', 'NK-cells (Spleen)': '0.233', 'Amygdala excitatory': '8.2', 'Cerebellar inhibitory': '9.8', 'Cge interneuron': '9.7', 'Deep-layer corticothalamic and 6b': '9.5', 'Deep-layer intratelencephalic': '8.5', 'Deep-layer near-projecting': '6.7', 'Eccentric medium spiny neuron': '10.8', 'Hippocampal ca1-3': '8.9', 'Hippocampal ca4': '5.9', 'Hippocampal dentate gyrus': '7.5', 'Lamp5-lhx6 and chandelier': '7.9', 'Lower rhombic lip': '5.1', 'Mammillary body': '5.6', 'Medium spiny neuron': '7.5', 'Mge interneuron': '8.0', 'Midbrain-derived inhibitory': '16.8', 'Miscellaneous': '10.0', 'Splatter': '8.0', 'Thalamic excitatory': '8.0', 'Upper rhombic lip': '13.2', 'Upper-layer intratelencephalic': '8.0', 'Astrocyte': '40.9', 'Bergmann glia': '14.2', 'Central nervous system macrophage': '47.0', 'Choroid plexus epithelial cell': '26.1', 'Committed oligodendrocyte precursor': '13.8', 'Ependymal cell': '22.6', 'Oligodendrocyte': '11.5', 'Oligodendrocyte precursor cell': '13.6', 'Endothelial cell': '125.3', 'Pericyte': '32.7', 'Vascular associated smooth muscle cell': '61.1', 'Fibroblast': '46.1', 'Leukocyte': '128.3', 'Basophil': '197.9', 'Eosinophil': '51.9', 'Neutrophil': '2173.5', 'Classical monocyte': '5002.1', 'Non-classical monocyte': '1782.9', 'Intermediate monocyte': '446.6', 'T-reg': '152.7', 'GdT-cell': '15.0', 'MAIT T-cell': '204.8', 'Memory CD4 T-cell': '19.1', 'Naive CD4 T-cell': '1084.0', 'Memory CD8 T-cell': '16.6', 'Naive CD8 T-cell': '929.5', 'Memory B-cell': '12.6', 'Naive B-cell': '452.6', 'Plasmacytoid DC': '115.0', 'Myeloid DC': '479.2', 'NK-cell': '983.4', 'Total PBMC': '280.7', 'Vd2 gdTCR': '171.8', 'Memory CD4 T-cell Th1\\/Th17': '1242.0', 'Memory CD4 T-cell Th17': '1070.7', 'Memory CD4 T-cell Th2': '1117.5', 'Non-Vd2 gdTCR': '142.1', 'Memory CD4 T-cell Th1': '897.5', 'Memory CD4 T-cell TFH': '838.0', 'Terminal effector memory CD4 T-cell': '161.6', 'Central memory CD8 T-cell': '190.7', 'Effector memory CD8 T-cell': '173.4', 'Terminal effector memory CD8 T-cell': '144.5', 'Non-switched memory B-cell': '124.7', 'Plasmablast': '248.3', 'Switched memory B-cell': '145.6', 'Exhausted memory B-cell': '153.7', 'Progenitor cell': '85.4', 'Memory T-reg': '852.7', 'Naive CD4 T-cell activated': '1072.1', 'Naive CD8 T-cell activated': '1057.4', 'Naive T-reg': '935.2'}
2KBW, 2MHS, 2NL9, 2NLA, 2PQK, 3D7V, 3IO9, 3KJ0, 3KJ1, 3KJ2, 3KZ0, 3MK8, 3PK1, 3TWU, 3WIX, 3WIY, 4BPI, 4BPJ, 4HW2, 4HW3, 4HW4, 4OQ5, 4OQ6, 4WGI, 4WMR, 4WMS, 4WMT, 4WMU, 4WMV, 4WMW, 4WMX, 4ZBF, 4ZBI, 5C3F, 5C6H, 5FC4, 5FDO, 5FDR, 5IEZ, 5IF4, 5JSB, 5KU9, 5LOF, 5MES, 5MEV, 5UUM, 5VKC, 5VX2, 5W89, 5W8F, 6B4L, 6B4U, 6BW2, 6BW8, 6FS0, 6FS1, 6FS2, 6MBD, 6MBE, 6NE5, 6O4U, 6O6F, 6O6G, 6OQB, 6OQC, 6OQD, 6OQN, 6OVC, 6P3P, 6QB3, 6QB4, 6QB6, 6QFC, 6QFI, 6QFM, 6QFQ, 6QGD, 6QXJ, 6QYK, 6QYL, 6QYN, 6QYO, 6QYP, 6QZ5, 6QZ6, 6QZ7, 6QZ8, 6QZB, 6STJ, 6U63, 6U64, 6U65, 6U67, 6U6F, 6UA3, 6UAB, 6UD2, 6UDI, 6UDT, 6UDU, 6UDV, 6UDX, 6UDY, 6VBX, 6YBG, 6YBJ, 6YBK, 6YBL, 6ZIE, 7NB4, 7NB7, 7XGE, 8AV9, 8EKX, 8EL0, 8EL1, 8G3S, 8G3T, 8G3U, 8G3W, 8G3X, 8G3Y, 8H7B, 8IQM, 8QSO, 8SVY, 8T6F, 8VJP
{'Adipose Tissue': 350.47304817275744, 'Adrenal Gland': 169.51244186046512, 'Bladder': 214.9771428571429, 'Blood': 417.495780409042, 'Blood Vessel': 330.1543970037453, 'Brain': 56.15663701741105, 'Breast': 273.10058823529414, 'Cervix Uteri': 182.5421052631579, 'Colon': 227.17679075738127, 'Esophagus': 254.64896193771625, 'Fallopian Tube': 440.5, 'Heart': 97.38246341463416, 'Kidney': 104.11067415730338, 'Liver': 144.41384955752213, 'Lung': 500.5269896193771, 'Muscle': 124.42875466998754, 'Nerve': 298.8604200323102, 'Ovary': 230.5691111111111, 'Pancreas': 108.16524390243902, 'Pituitary': 163.3028621908127, 'Prostate': 160.88604081632653, 'Salivary Gland': 205.08827160493829, 'Skin': 310.05712548369263, 'Small Intestine': 230.6979679144385, 'Spleen': 292.63236514522816, 'Stomach': 235.7885515320334, 'Testis': 92.07828254847648, 'Thyroid': 237.49560490045943, 'Uterus': 225.58830985915495, 'Vagina': 252.8044871794872}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
63.504286
0.625571
2,174
O60260
Q12904
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
AIMP1
MANNDAVLKRLEQKGAEADQIIEYLKQQVSLLKEKAILQATLREEKKLRVENAKLKKEIEELKQELIQAEIQNGVKQIPFPSGTPLHANSMVSENVIQSTAVTTVSSGTKEQIKGGTGDEKKAKEKIEKKGEKKEKKQQSIAGSADSKPIDVSRLDLRIGCIITARKHPDADSLYVEEVDVGEIAPRTVVSGLVNHVPLEQMQNRMVILLCNLKPAKMRGVLSQAMVMCASSPEKIEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQPDLHTNDECVATYKGVPFEVKGKGVCRAQTMSNSGIK
Homo sapiens
Nucleus, Cytoplasm, cytosol, Secreted, Endoplasmic reticulum, Golgi apparatus
Low tissue specificity
{'Ciliated cells': '83.7', 'Basal respiratory cells': '163.9', 'Club cells': '103.0', 'Ionocytes': '123.0', 'Mucus glandular cells': '61.7', 'Serous glandular cells': '83.9', 'Gastric mucus-secreting cells': '57.2', 'Proximal enterocytes': '151.4', 'Paneth cells': '96.8', 'Distal enterocytes': '85.7', 'Intestinal goblet cells': '117.2', 'Exocrine glandular cells': '-0.759', 'Basal prostatic cells': '96.3', 'Prostatic glandular cells': '60.2', 'Breast glandular cells': '0.535', 'Breast myoepithelial cells': '0.462', 'Glandular and luminal cells': '172.3', 'Secretory cells': '103.6', 'Basal keratinocytes': '78.5', 'Suprabasal keratinocytes': '98.4', 'Basal squamous epithelial cells': '61.6', 'Squamous epithelial cells': '75.4', 'Alveolar cells type 1': '0.094', 'Alveolar cells type 2': '0.090', 'Salivary duct cells': '64.3', 'Ductal cells': '0.559', 'Hepatocytes': '0.393', 'Cholangiocytes': '87.8', 'Proximal tubular cells': '0.232', 'Distal tubular cells': '135.2', 'Collecting duct cells': '62.2', 'Mesothelial cells': '0.275', 'Sertoli cells': '0.500', 'Granulosa cells': '90.9', 'Enteroendocrine cells': '99.6', 'Pancreatic endocrine cells': '137.5', 'Leydig cells': '0.579', 'Excitatory neurons': '16.8', 'Inhibitory neurons': '19.6', 'Cone photoreceptor cells': '59.5', 'Rod photoreceptor cells': '62.4', 'Bipolar cells': '55.2', 'Horizontal cells': '39.0', 'Astrocytes': '17.6', 'Oligodendrocyte precursor cells': '23.1', 'Oligodendrocytes': '35.6', 'Microglial cells': '16.1', 'Muller glia cells': '58.5', 'Schwann cells': '0.069', 'Spermatogonia': '0.538', 'Spermatocytes': '0.321', 'Early spermatids': '-0.171', 'Late spermatids': '-0.578', 'Oocytes': '77.2', 'Cytotrophoblasts': '135.6', 'Syncytiotrophoblasts': '167.8', 'Extravillous trophoblasts': '160.9', 'Endothelial cells': '70.7', 'Lymphatic endothelial cells': '68.4', 'Cardiomyocytes': '0.625', 'Skeletal myocytes': '-0.131', 'Smooth muscle cells': '81.9', 'Adipocytes': '90.4', 'Melanocytes': '0.118', 'Fibroblasts': '78.8', 'Peritubular cells': '0.425', 'Endometrial stromal cells': '98.1', 'Ovarian stromal cells': '124.6', 'Undifferentiated cells': '128.0', 'T-cells': '81.8', 'B-cells': '77.9', 'Plasma cells': '60.2', 'Nk-cells': '83.1', 'Granulocytes': '81.1', 'Monocytes': '120.1', 'Macrophages': '75.5', 'Hofbauer cells': '120.2', 'Kupffer cells': '91.9', 'Dendritic cells': '87.2', 'Langerhans cells': '0.185', 'Erythroid cells': '-0.054', 'Adipocytes (Subcutaneous)': '-0.143', 'Adipocytes (Visceral)': '-0.236', 'Breast glandular cells (progenitors)': '0.358', 'Adipocytes (Breast)': '-0.477', 'Colon enterocytes': '-0.172', 'Colon enteroendocrine cells': '0.274', 'Enteric glia cells': '-0.094', 'Mitotic cells (Colon)': '-0.086', 'Mitotic cells (Heart)': '0.503', 'Podocytes': '0.017', 'Ascending Loop of Henle cells': '0.400', 'Intercalated cells': '0.050', 'Cholangiocyte': '0.368', 'NK-cells (Liver)': '-0.378', 'Respiratory ciliated cells': '0.015', 'Mitotic cells (Lung)': '0.009', 'NK-cells (Lung)': '-0.124', 'B-cells (Lung)': '-0.222', 'Alpha cells': '0.372', 'Beta cells': '0.196', 'Prostate glandular cells': '-0.052', 'Prostate basal glandular cells': '0.284', 'Urothelial cells': '0.168', 'Keratinocyte (other)': '0.028', 'Keratinocyte (granular)': '-0.099', 'Hair cortex cells': '-0.042', 'Inner root sheath cells': '0.055', 'Outer root sheath cells': '0.146', 'Sebaceous gland cells': '0.131', 'Eccrine sweat gland cells': '0.032', 'Adipocytes (Skin)': '-0.018', 'Mitotic cells (Skin)': '0.174', 'Parietal cells': '-0.593', 'Chief cells': '-0.471', 'Gastric mucous cells': '-0.305', 'Gastric enteroendocrine cells': '-0.374', 'Mitotic cells (Stomach)': '0.123', 'Parafollicular cells': '0.089', 'Thyroid glandular cells': '0.439', 'Mitotic cells (Thyroid)': '-0.046', 'Adrenal cortex cells': '0.253', 'Adrenal medulla cells': '-0.041', 'Mitotic cells (Adrenal gland)': '0.190', 'Minor salivary glandular cells': '0.418', 'Minor salivary gland ductal cells': '0.032', 'Minor salivary gland basal cells': '0.449', 'Mitotic cells (Minor salivary gland)': '0.442', 'Adipocytes (Minor salivary gland)': '0.154', 'Somatotropes': '0.124', 'Lactotropes': '0.063', 'Gonadotropes': '-0.032', 'Corticotropes': '-0.077', 'Thyrotropes': '0.148', 'Undifferentiated cells (Pituitary gland)': '0.135', 'Mitotic cells (Spleen)': '-0.241', 'Platelets': '-0.237', 'Erythrocytes': '-0.145', 'Hematopoietic stem cells': '-0.308', 'B-cells (Spleen)': '0.462', 'NK-cells (Spleen)': '0.316', 'Amygdala excitatory': '24.0', 'Cerebellar inhibitory': '33.2', 'Cge interneuron': '32.1', 'Deep-layer corticothalamic and 6b': '27.4', 'Deep-layer intratelencephalic': '25.4', 'Deep-layer near-projecting': '26.8', 'Eccentric medium spiny neuron': '38.6', 'Hippocampal ca1-3': '24.8', 'Hippocampal ca4': '31.4', 'Hippocampal dentate gyrus': '35.0', 'Lamp5-lhx6 and chandelier': '29.0', 'Lower rhombic lip': '26.5', 'Mammillary body': '33.6', 'Medium spiny neuron': '35.1', 'Mge interneuron': '29.0', 'Midbrain-derived inhibitory': '25.8', 'Miscellaneous': '27.3', 'Splatter': '30.2', 'Thalamic excitatory': '29.3', 'Upper rhombic lip': '37.1', 'Upper-layer intratelencephalic': '24.0', 'Astrocyte': '36.7', 'Bergmann glia': '41.0', 'Central nervous system macrophage': '54.1', 'Choroid plexus epithelial cell': '37.6', 'Committed oligodendrocyte precursor': '38.9', 'Ependymal cell': '34.2', 'Oligodendrocyte': '59.4', 'Oligodendrocyte precursor cell': '37.4', 'Endothelial cell': '45.5', 'Pericyte': '59.1', 'Vascular associated smooth muscle cell': '46.0', 'Fibroblast': '46.4', 'Leukocyte': '44.1', 'Basophil': '45.7', 'Eosinophil': '63.9', 'Neutrophil': '5.6', 'Classical monocyte': '50.2', 'Non-classical monocyte': '70.8', 'Intermediate monocyte': '76.9', 'T-reg': '85.8', 'GdT-cell': '48.0', 'MAIT T-cell': '63.4', 'Memory CD4 T-cell': '61.4', 'Naive CD4 T-cell': '106.1', 'Memory CD8 T-cell': '50.7', 'Naive CD8 T-cell': '89.2', 'Memory B-cell': '64.7', 'Naive B-cell': '77.9', 'Plasmacytoid DC': '84.9', 'Myeloid DC': '90.7', 'NK-cell': '55.9', 'Total PBMC': '80.6', 'Vd2 gdTCR': '73.8', 'Memory CD4 T-cell Th1\\/Th17': '95.9', 'Memory CD4 T-cell Th17': '93.9', 'Memory CD4 T-cell Th2': '96.3', 'Non-Vd2 gdTCR': '58.8', 'Memory CD4 T-cell Th1': '86.3', 'Memory CD4 T-cell TFH': '85.9', 'Terminal effector memory CD4 T-cell': '39.4', 'Central memory CD8 T-cell': '67.3', 'Effector memory CD8 T-cell': '64.8', 'Terminal effector memory CD8 T-cell': '55.0', 'Non-switched memory B-cell': '73.3', 'Plasmablast': '68.8', 'Switched memory B-cell': '62.0', 'Exhausted memory B-cell': '62.4', 'Progenitor cell': '56.0', 'Memory T-reg': '85.6', 'Naive CD4 T-cell activated': '138.3', 'Naive CD8 T-cell activated': '134.2', 'Naive T-reg': '107.7'}
1E7Z, 1EUJ, 1FL0, 4R3Z, 8J9S, 8ONG
{'Adipose Tissue': 35.05451744186047, 'Adrenal Gland': 28.256515503875967, 'Bladder': 41.16952380952381, 'Blood': 16.228145748116255, 'Blood Vessel': 49.430576779026225, 'Brain': 19.067408781226344, 'Breast': 38.83790849673202, 'Cervix Uteri': 43.834736842105265, 'Colon': 35.5182028241335, 'Esophagus': 34.96322491349481, 'Fallopian Tube': 45.00222222222222, 'Heart': 15.628777003484322, 'Kidney': 21.553573033707867, 'Liver': 14.809898230088494, 'Lung': 35.93574394463668, 'Muscle': 31.861606475716066, 'Nerve': 44.84875605815832, 'Ovary': 45.15355555555555, 'Pancreas': 14.616652439024389, 'Pituitary': 33.203710247349825, 'Prostate': 37.68489795918367, 'Salivary Gland': 30.586296296296293, 'Skin': 40.064543946932005, 'Small Intestine': 33.45155080213903, 'Spleen': 34.11431535269709, 'Stomach': 27.899526462395546, 'Testis': 25.24243767313019, 'Thyroid': 39.10623277182235, 'Uterus': 44.30781690140845, 'Vagina': 38.21134615384616}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
80.6775
0.522436
2,338
O60260
Q13049
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
TRIM32
MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQARYKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRTVNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEILHFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP
Homo sapiens
Cytoplasm, Mitochondrion, Endoplasmic reticulum
Low tissue specificity
{'Ciliated cells': '11.5', 'Basal respiratory cells': '8.8', 'Club cells': '7.1', 'Ionocytes': '4.8', 'Mucus glandular cells': '1.8', 'Serous glandular cells': '4.1', 'Gastric mucus-secreting cells': '3.5', 'Proximal enterocytes': '10.8', 'Paneth cells': '4.6', 'Distal enterocytes': '2.1', 'Intestinal goblet cells': '6.4', 'Exocrine glandular cells': '-0.507', 'Basal prostatic cells': '5.4', 'Prostatic glandular cells': '3.8', 'Breast glandular cells': '0.441', 'Breast myoepithelial cells': '0.488', 'Glandular and luminal cells': '2.2', 'Secretory cells': '5.2', 'Basal keratinocytes': '3.4', 'Suprabasal keratinocytes': '3.5', 'Basal squamous epithelial cells': '4.9', 'Squamous epithelial cells': '5.5', 'Alveolar cells type 1': '-0.084', 'Alveolar cells type 2': '0.003', 'Salivary duct cells': '2.4', 'Ductal cells': '0.664', 'Hepatocytes': '0.451', 'Cholangiocytes': '3.8', 'Proximal tubular cells': '0.163', 'Distal tubular cells': '0.0', 'Collecting duct cells': '5.8', 'Mesothelial cells': '0.435', 'Sertoli cells': '0.290', 'Granulosa cells': '2.3', 'Enteroendocrine cells': '3.2', 'Pancreatic endocrine cells': '5.1', 'Leydig cells': '0.367', 'Excitatory neurons': '7.4', 'Inhibitory neurons': '9.7', 'Cone photoreceptor cells': '3.4', 'Rod photoreceptor cells': '4.5', 'Bipolar cells': '11.8', 'Horizontal cells': '5.7', 'Astrocytes': '5.3', 'Oligodendrocyte precursor cells': '6.1', 'Oligodendrocytes': '4.7', 'Microglial cells': '1.8', 'Muller glia cells': '2.6', 'Schwann cells': '0.101', 'Spermatogonia': '0.563', 'Spermatocytes': '0.577', 'Early spermatids': '-0.247', 'Late spermatids': '-0.420', 'Oocytes': '2.2', 'Cytotrophoblasts': '6.8', 'Syncytiotrophoblasts': '7.7', 'Extravillous trophoblasts': '3.6', 'Endothelial cells': '3.2', 'Lymphatic endothelial cells': '1.2', 'Cardiomyocytes': '0.666', 'Skeletal myocytes': '-0.097', 'Smooth muscle cells': '6.0', 'Adipocytes': '2.3', 'Melanocytes': '0.228', 'Fibroblasts': '6.8', 'Peritubular cells': '0.346', 'Endometrial stromal cells': '10.6', 'Ovarian stromal cells': '4.7', 'Undifferentiated cells': '5.9', 'T-cells': '4.1', 'B-cells': '3.3', 'Plasma cells': '3.0', 'Nk-cells': '2.7', 'Granulocytes': '4.5', 'Monocytes': '0.4', 'Macrophages': '2.9', 'Hofbauer cells': '6.1', 'Kupffer cells': '2.4', 'Dendritic cells': '0.8', 'Langerhans cells': '0.308', 'Erythroid cells': '-0.054', 'Adipocytes (Subcutaneous)': '-0.196', 'Adipocytes (Visceral)': '-0.269', 'Breast glandular cells (progenitors)': '0.432', 'Adipocytes (Breast)': '-0.315', 'Colon enterocytes': '-0.119', 'Colon enteroendocrine cells': '0.244', 'Enteric glia cells': '-0.023', 'Mitotic cells (Colon)': '-0.123', 'Mitotic cells (Heart)': '0.485', 'Podocytes': '-0.195', 'Ascending Loop of Henle cells': '0.467', 'Intercalated cells': '-0.026', 'Cholangiocyte': '0.363', 'NK-cells (Liver)': '-0.234', 'Respiratory ciliated cells': '0.155', 'Mitotic cells (Lung)': '0.155', 'NK-cells (Lung)': '-0.083', 'B-cells (Lung)': '-0.082', 'Alpha cells': '0.438', 'Beta cells': '0.280', 'Prostate glandular cells': '-0.403', 'Prostate basal glandular cells': '-0.009', 'Urothelial cells': '0.026', 'Keratinocyte (other)': '0.050', 'Keratinocyte (granular)': '-0.158', 'Hair cortex cells': '0.105', 'Inner root sheath cells': '0.114', 'Outer root sheath cells': '0.259', 'Sebaceous gland cells': '0.155', 'Eccrine sweat gland cells': '0.079', 'Adipocytes (Skin)': '0.095', 'Mitotic cells (Skin)': '0.489', 'Parietal cells': '-0.633', 'Chief cells': '-0.563', 'Gastric mucous cells': '-0.417', 'Gastric enteroendocrine cells': '-0.402', 'Mitotic cells (Stomach)': '0.049', 'Parafollicular cells': '0.019', 'Thyroid glandular cells': '0.270', 'Mitotic cells (Thyroid)': '0.147', 'Adrenal cortex cells': '0.585', 'Adrenal medulla cells': '0.018', 'Mitotic cells (Adrenal gland)': '0.394', 'Minor salivary glandular cells': '0.398', 'Minor salivary gland ductal cells': '0.031', 'Minor salivary gland basal cells': '0.262', 'Mitotic cells (Minor salivary gland)': '0.411', 'Adipocytes (Minor salivary gland)': '0.280', 'Somatotropes': '-0.048', 'Lactotropes': '-0.053', 'Gonadotropes': '0.000', 'Corticotropes': '-0.180', 'Thyrotropes': '0.067', 'Undifferentiated cells (Pituitary gland)': '0.379', 'Mitotic cells (Spleen)': '-0.082', 'Platelets': '-0.157', 'Erythrocytes': '-0.141', 'Hematopoietic stem cells': '-0.283', 'B-cells (Spleen)': '0.351', 'NK-cells (Spleen)': '0.246', 'Amygdala excitatory': '11.4', 'Cerebellar inhibitory': '22.1', 'Cge interneuron': '15.3', 'Deep-layer corticothalamic and 6b': '10.2', 'Deep-layer intratelencephalic': '9.6', 'Deep-layer near-projecting': '12.7', 'Eccentric medium spiny neuron': '9.6', 'Hippocampal ca1-3': '11.0', 'Hippocampal ca4': '10.4', 'Hippocampal dentate gyrus': '12.0', 'Lamp5-lhx6 and chandelier': '15.5', 'Lower rhombic lip': '14.1', 'Mammillary body': '20.4', 'Medium spiny neuron': '8.3', 'Mge interneuron': '15.6', 'Midbrain-derived inhibitory': '17.7', 'Miscellaneous': '9.7', 'Splatter': '12.6', 'Thalamic excitatory': '15.2', 'Upper rhombic lip': '20.5', 'Upper-layer intratelencephalic': '8.5', 'Astrocyte': '5.3', 'Bergmann glia': '11.4', 'Central nervous system macrophage': '7.3', 'Choroid plexus epithelial cell': '25.0', 'Committed oligodendrocyte precursor': '6.4', 'Ependymal cell': '9.9', 'Oligodendrocyte': '6.1', 'Oligodendrocyte precursor cell': '12.7', 'Endothelial cell': '5.2', 'Pericyte': '8.3', 'Vascular associated smooth muscle cell': '6.9', 'Fibroblast': '10.4', 'Leukocyte': '5.7', 'Basophil': '0.8', 'Eosinophil': '0.0', 'Neutrophil': '0.0', 'Classical monocyte': '0.6', 'Non-classical monocyte': '1.0', 'Intermediate monocyte': '4.3', 'T-reg': '24.8', 'GdT-cell': '10.9', 'MAIT T-cell': '15.0', 'Memory CD4 T-cell': '9.5', 'Naive CD4 T-cell': '13.0', 'Memory CD8 T-cell': '8.7', 'Naive CD8 T-cell': '11.2', 'Memory B-cell': '7.3', 'Naive B-cell': '6.3', 'Plasmacytoid DC': '15.1', 'Myeloid DC': '2.3', 'NK-cell': '16.1', 'Total PBMC': '11.7', 'Vd2 gdTCR': '17.2', 'Memory CD4 T-cell TFH': '22.7', 'Memory CD4 T-cell Th2': '15.8', 'Memory CD4 T-cell Th17': '14.6', 'Memory CD4 T-cell Th1\\/Th17': '8.4', 'Non-Vd2 gdTCR': '17.5', 'Memory CD4 T-cell Th1': '12.0', 'Terminal effector memory CD4 T-cell': '18.7', 'Central memory CD8 T-cell': '17.0', 'Effector memory CD8 T-cell': '20.1', 'Terminal effector memory CD8 T-cell': '16.8', 'Switched memory B-cell': '15.1', 'Plasmablast': '18.1', 'Non-switched memory B-cell': '15.7', 'Exhausted memory B-cell': '14.5', 'Progenitor cell': '12.9', 'Naive CD4 T-cell activated': '13.0', 'Naive CD8 T-cell activated': '14.1', 'Memory T-reg': '27.8', 'Naive T-reg': '18.9'}
2CT2, 5FEY
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
79.374456
0.429219
1,119
O60260
Q13137
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
CALCOCO2
MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL
Homo sapiens
Cytoplasm, perinuclear region, Cytoplasm, cytoskeleton, Cytoplasmic vesicle, autophagosome membrane
Low tissue specificity
{'Ciliated cells': '35.3', 'Basal respiratory cells': '39.9', 'Club cells': '44.3', 'Ionocytes': '25.4', 'Mucus glandular cells': '45.8', 'Serous glandular cells': '55.9', 'Gastric mucus-secreting cells': '33.6', 'Proximal enterocytes': '77.7', 'Paneth cells': '54.1', 'Distal enterocytes': '117.8', 'Intestinal goblet cells': '42.1', 'Exocrine glandular cells': '-0.609', 'Basal prostatic cells': '88.2', 'Prostatic glandular cells': '57.8', 'Breast glandular cells': '-0.183', 'Breast myoepithelial cells': '-0.383', 'Glandular and luminal cells': '47.1', 'Secretory cells': '58.5', 'Basal keratinocytes': '41.5', 'Suprabasal keratinocytes': '79.4', 'Basal squamous epithelial cells': '39.0', 'Squamous epithelial cells': '59.0', 'Alveolar cells type 1': '0.304', 'Alveolar cells type 2': '-0.259', 'Salivary duct cells': '47.4', 'Ductal cells': '0.480', 'Hepatocytes': '0.504', 'Cholangiocytes': '34.3', 'Proximal tubular cells': '0.182', 'Distal tubular cells': '40.0', 'Collecting duct cells': '29.2', 'Mesothelial cells': '0.136', 'Sertoli cells': '-0.500', 'Granulosa cells': '37.1', 'Enteroendocrine cells': '60.5', 'Pancreatic endocrine cells': '40.8', 'Leydig cells': '-0.466', 'Excitatory neurons': '29.9', 'Inhibitory neurons': '20.3', 'Cone photoreceptor cells': '71.4', 'Rod photoreceptor cells': '70.1', 'Bipolar cells': '18.4', 'Horizontal cells': '12.0', 'Astrocytes': '19.5', 'Oligodendrocyte precursor cells': '25.0', 'Oligodendrocytes': '25.4', 'Microglial cells': '26.8', 'Muller glia cells': '44.8', 'Schwann cells': '0.152', 'Spermatogonia': '-0.187', 'Spermatocytes': '0.184', 'Early spermatids': '0.754', 'Late spermatids': '0.635', 'Oocytes': '54.4', 'Cytotrophoblasts': '49.9', 'Syncytiotrophoblasts': '82.7', 'Extravillous trophoblasts': '49.1', 'Endothelial cells': '129.0', 'Lymphatic endothelial cells': '98.0', 'Cardiomyocytes': '0.716', 'Skeletal myocytes': '-0.315', 'Smooth muscle cells': '89.1', 'Adipocytes': '163.1', 'Melanocytes': '-0.087', 'Fibroblasts': '90.1', 'Peritubular cells': '-0.292', 'Endometrial stromal cells': '91.9', 'Ovarian stromal cells': '59.7', 'Undifferentiated cells': '59.4', 'T-cells': '57.2', 'B-cells': '42.1', 'Plasma cells': '56.7', 'Nk-cells': '57.2', 'Granulocytes': '80.7', 'Monocytes': '135.1', 'Macrophages': '76.9', 'Hofbauer cells': '39.7', 'Kupffer cells': '97.9', 'Dendritic cells': '56.6', 'Langerhans cells': '0.072', 'Erythroid cells': '0.045', 'Adipocytes (Subcutaneous)': '0.180', 'Adipocytes (Visceral)': '-0.122', 'Breast glandular cells (progenitors)': '-0.234', 'Adipocytes (Breast)': '0.400', 'Colon enterocytes': '-0.083', 'Colon enteroendocrine cells': '0.152', 'Enteric glia cells': '-0.134', 'Mitotic cells (Colon)': '0.023', 'Mitotic cells (Heart)': '0.390', 'Podocytes': '0.047', 'Ascending Loop of Henle cells': '0.398', 'Intercalated cells': '0.008', 'Cholangiocyte': '0.421', 'NK-cells (Liver)': '-0.295', 'Respiratory ciliated cells': '0.030', 'Mitotic cells (Lung)': '-0.252', 'NK-cells (Lung)': '0.187', 'B-cells (Lung)': '-0.012', 'Alpha cells': '0.405', 'Beta cells': '0.245', 'Prostate glandular cells': '-0.321', 'Prostate basal glandular cells': '-0.003', 'Urothelial cells': '0.013', 'Keratinocyte (other)': '0.026', 'Keratinocyte (granular)': '0.148', 'Hair cortex cells': '-0.193', 'Inner root sheath cells': '-0.127', 'Outer root sheath cells': '-0.162', 'Sebaceous gland cells': '-0.008', 'Eccrine sweat gland cells': '0.002', 'Adipocytes (Skin)': '0.152', 'Mitotic cells (Skin)': '0.022', 'Parietal cells': '-0.668', 'Chief cells': '-0.614', 'Gastric mucous cells': '-0.433', 'Gastric enteroendocrine cells': '-0.449', 'Mitotic cells (Stomach)': '-0.014', 'Parafollicular cells': '-0.019', 'Thyroid glandular cells': '0.476', 'Mitotic cells (Thyroid)': '-0.037', 'Adrenal cortex cells': '0.526', 'Adrenal medulla cells': '0.047', 'Mitotic cells (Adrenal gland)': '0.363', 'Minor salivary glandular cells': '0.330', 'Minor salivary gland ductal cells': '-0.057', 'Minor salivary gland basal cells': '0.577', 'Mitotic cells (Minor salivary gland)': '0.588', 'Adipocytes (Minor salivary gland)': '0.430', 'Somatotropes': '0.038', 'Lactotropes': '-0.236', 'Gonadotropes': '-0.065', 'Corticotropes': '-0.070', 'Thyrotropes': '0.045', 'Undifferentiated cells (Pituitary gland)': '0.188', 'Mitotic cells (Spleen)': '-0.391', 'Platelets': '-0.072', 'Erythrocytes': '-0.095', 'Hematopoietic stem cells': '-0.198', 'B-cells (Spleen)': '0.184', 'NK-cells (Spleen)': '0.326', 'Amygdala excitatory': '45.5', 'Cerebellar inhibitory': '28.2', 'Cge interneuron': '31.7', 'Deep-layer corticothalamic and 6b': '61.5', 'Deep-layer intratelencephalic': '54.8', 'Deep-layer near-projecting': '35.2', 'Eccentric medium spiny neuron': '26.2', 'Hippocampal ca1-3': '47.0', 'Hippocampal ca4': '30.6', 'Hippocampal dentate gyrus': '25.0', 'Lamp5-lhx6 and chandelier': '31.2', 'Lower rhombic lip': '40.5', 'Mammillary body': '37.9', 'Medium spiny neuron': '17.6', 'Mge interneuron': '31.8', 'Midbrain-derived inhibitory': '51.9', 'Miscellaneous': '38.1', 'Splatter': '31.1', 'Thalamic excitatory': '30.4', 'Upper rhombic lip': '33.2', 'Upper-layer intratelencephalic': '48.8', 'Astrocyte': '60.7', 'Bergmann glia': '56.1', 'Central nervous system macrophage': '48.1', 'Choroid plexus epithelial cell': '202.3', 'Committed oligodendrocyte precursor': '36.2', 'Ependymal cell': '45.0', 'Oligodendrocyte': '44.9', 'Oligodendrocyte precursor cell': '42.2', 'Endothelial cell': '136.8', 'Pericyte': '109.3', 'Vascular associated smooth muscle cell': '58.5', 'Fibroblast': '124.4', 'Leukocyte': '60.6', 'Basophil': '458.7', 'Eosinophil': '116.1', 'Neutrophil': '660.1', 'Classical monocyte': '94.9', 'Non-classical monocyte': '116.4', 'Intermediate monocyte': '538.5', 'T-reg': '221.2', 'GdT-cell': '56.7', 'MAIT T-cell': '218.6', 'Memory CD4 T-cell': '50.1', 'Naive CD4 T-cell': '72.1', 'Memory CD8 T-cell': '58.9', 'Naive CD8 T-cell': '54.6', 'Memory B-cell': '54.3', 'Naive B-cell': '70.7', 'Plasmacytoid DC': '252.7', 'Myeloid DC': '268.7', 'NK-cell': '71.0', 'Total PBMC': '288.1', 'Vd2 gdTCR': '213.7', 'Memory CD4 T-cell TFH': '51.9', 'Memory CD4 T-cell Th2': '65.7', 'Memory CD4 T-cell Th17': '63.9', 'Memory CD4 T-cell Th1\\/Th17': '60.6', 'Non-Vd2 gdTCR': '235.7', 'Memory CD4 T-cell Th1': '53.2', 'Terminal effector memory CD4 T-cell': '181.1', 'Central memory CD8 T-cell': '189.5', 'Effector memory CD8 T-cell': '261.6', 'Terminal effector memory CD8 T-cell': '243.1', 'Switched memory B-cell': '194.6', 'Plasmablast': '178.1', 'Non-switched memory B-cell': '222.8', 'Exhausted memory B-cell': '209.3', 'Progenitor cell': '284.2', 'Naive CD4 T-cell activated': '49.5', 'Naive CD8 T-cell activated': '53.2', 'Memory T-reg': '82.0', 'Naive T-reg': '61.5'}
2MXP, 3VVV, 3VVW, 4GXL, 4HAN, 4XKL, 5AAQ, 5Z7A, 5Z7L, 7EAA
{'Adipose Tissue': 91.64185215946844, 'Adrenal Gland': 39.07306201550388, 'Bladder': 72.87380952380953, 'Blood': 31.316248654467167, 'Blood Vessel': 96.43786516853932, 'Brain': 18.4832153671461, 'Breast': 83.05220043572984, 'Cervix Uteri': 81.65631578947368, 'Colon': 61.74057766367138, 'Esophagus': 71.53300346020761, 'Fallopian Tube': 86.64333333333333, 'Heart': 46.71745296167247, 'Kidney': 28.821449438202247, 'Liver': 22.025690265486723, 'Lung': 89.07081314878893, 'Muscle': 54.69138231631382, 'Nerve': 114.35214862681744, 'Ovary': 73.70972222222223, 'Pancreas': 16.2804756097561, 'Pituitary': 46.968233215547706, 'Prostate': 53.93587755102041, 'Salivary Gland': 37.45611111111111, 'Skin': 57.07656163626313, 'Small Intestine': 53.460320855614974, 'Spleen': 53.271369294605805, 'Stomach': 48.74688022284123, 'Testis': 81.44487534626039, 'Thyroid': 68.81981623277181, 'Uterus': 80.3180985915493, 'Vagina': 75.17128205128205}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
79.969148
0.57565
1,781
O60260
Q13148
23258539
UbiNet, UbiBrowser
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
TARDBP
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
Homo sapiens
Nucleus, Cytoplasm, Cytoplasm, Stress granule, Mitochondrion
Low tissue specificity
{'Ciliated cells': '47.3', 'Basal respiratory cells': '41.9', 'Club cells': '50.0', 'Ionocytes': '51.5', 'Mucus glandular cells': '49.7', 'Serous glandular cells': '45.2', 'Gastric mucus-secreting cells': '46.6', 'Proximal enterocytes': '46.2', 'Paneth cells': '47.4', 'Distal enterocytes': '56.1', 'Intestinal goblet cells': '59.0', 'Exocrine glandular cells': '-0.634', 'Basal prostatic cells': '61.2', 'Prostatic glandular cells': '50.0', 'Breast glandular cells': '0.578', 'Breast myoepithelial cells': '0.537', 'Glandular and luminal cells': '70.3', 'Secretory cells': '57.1', 'Basal keratinocytes': '96.2', 'Suprabasal keratinocytes': '96.8', 'Basal squamous epithelial cells': '56.5', 'Squamous epithelial cells': '62.7', 'Alveolar cells type 1': '0.230', 'Alveolar cells type 2': '-0.408', 'Salivary duct cells': '52.9', 'Ductal cells': '0.663', 'Hepatocytes': '0.415', 'Cholangiocytes': '22.9', 'Proximal tubular cells': '0.218', 'Distal tubular cells': '33.8', 'Collecting duct cells': '33.1', 'Mesothelial cells': '0.377', 'Sertoli cells': '0.440', 'Granulosa cells': '51.5', 'Enteroendocrine cells': '57.7', 'Pancreatic endocrine cells': '44.1', 'Leydig cells': '0.430', 'Excitatory neurons': '28.5', 'Inhibitory neurons': '28.5', 'Cone photoreceptor cells': '49.3', 'Rod photoreceptor cells': '61.4', 'Bipolar cells': '51.3', 'Horizontal cells': '42.2', 'Astrocytes': '27.9', 'Oligodendrocyte precursor cells': '34.9', 'Oligodendrocytes': '53.2', 'Microglial cells': '22.4', 'Muller glia cells': '46.9', 'Schwann cells': '0.199', 'Spermatogonia': '0.339', 'Spermatocytes': '0.233', 'Early spermatids': '-0.209', 'Late spermatids': '-0.602', 'Oocytes': '33.1', 'Cytotrophoblasts': '73.7', 'Syncytiotrophoblasts': '84.4', 'Extravillous trophoblasts': '93.8', 'Endothelial cells': '56.7', 'Lymphatic endothelial cells': '66.7', 'Cardiomyocytes': '0.603', 'Skeletal myocytes': '-0.130', 'Smooth muscle cells': '50.4', 'Adipocytes': '49.4', 'Melanocytes': '0.072', 'Fibroblasts': '54.2', 'Peritubular cells': '0.573', 'Endometrial stromal cells': '67.3', 'Ovarian stromal cells': '56.9', 'Undifferentiated cells': '63.0', 'T-cells': '55.0', 'B-cells': '64.3', 'Plasma cells': '58.0', 'Nk-cells': '69.0', 'Granulocytes': '52.3', 'Monocytes': '57.7', 'Macrophages': '50.9', 'Hofbauer cells': '56.0', 'Kupffer cells': '46.5', 'Dendritic cells': '69.9', 'Langerhans cells': '0.094', 'Erythroid cells': '-0.026', 'Adipocytes (Subcutaneous)': '-0.170', 'Adipocytes (Visceral)': '-0.275', 'Breast glandular cells (progenitors)': '0.406', 'Adipocytes (Breast)': '-0.488', 'Colon enterocytes': '-0.141', 'Colon enteroendocrine cells': '0.239', 'Enteric glia cells': '0.440', 'Mitotic cells (Colon)': '-0.150', 'Mitotic cells (Heart)': '0.434', 'Podocytes': '0.002', 'Ascending Loop of Henle cells': '0.434', 'Intercalated cells': '-0.012', 'Cholangiocyte': '0.259', 'NK-cells (Liver)': '-0.209', 'Respiratory ciliated cells': '0.103', 'Mitotic cells (Lung)': '-0.142', 'NK-cells (Lung)': '0.470', 'B-cells (Lung)': '0.221', 'Alpha cells': '0.433', 'Beta cells': '0.302', 'Prostate glandular cells': '-0.153', 'Prostate basal glandular cells': '0.347', 'Urothelial cells': '0.363', 'Keratinocyte (other)': '0.095', 'Keratinocyte (granular)': '-0.292', 'Hair cortex cells': '-0.051', 'Inner root sheath cells': '-0.030', 'Outer root sheath cells': '0.212', 'Sebaceous gland cells': '0.082', 'Eccrine sweat gland cells': '0.061', 'Adipocytes (Skin)': '-0.070', 'Mitotic cells (Skin)': '0.261', 'Parietal cells': '-0.659', 'Chief cells': '-0.522', 'Gastric mucous cells': '-0.316', 'Gastric enteroendocrine cells': '-0.337', 'Mitotic cells (Stomach)': '0.089', 'Parafollicular cells': '0.084', 'Thyroid glandular cells': '0.169', 'Mitotic cells (Thyroid)': '-0.032', 'Adrenal cortex cells': '0.282', 'Adrenal medulla cells': '0.034', 'Mitotic cells (Adrenal gland)': '0.024', 'Minor salivary glandular cells': '0.508', 'Minor salivary gland ductal cells': '0.225', 'Minor salivary gland basal cells': '0.323', 'Mitotic cells (Minor salivary gland)': '0.315', 'Adipocytes (Minor salivary gland)': '0.107', 'Somatotropes': '-0.039', 'Lactotropes': '-0.030', 'Gonadotropes': '0.005', 'Corticotropes': '-0.086', 'Thyrotropes': '0.205', 'Undifferentiated cells (Pituitary gland)': '0.272', 'Mitotic cells (Spleen)': '-0.099', 'Platelets': '-0.283', 'Erythrocytes': '-0.099', 'Hematopoietic stem cells': '-0.305', 'B-cells (Spleen)': '0.432', 'NK-cells (Spleen)': '0.296', 'Amygdala excitatory': '8.5', 'Cerebellar inhibitory': '9.4', 'Cge interneuron': '9.7', 'Deep-layer corticothalamic and 6b': '7.5', 'Deep-layer intratelencephalic': '8.6', 'Deep-layer near-projecting': '10.2', 'Eccentric medium spiny neuron': '11.3', 'Hippocampal ca1-3': '7.7', 'Hippocampal ca4': '8.0', 'Hippocampal dentate gyrus': '12.8', 'Lamp5-lhx6 and chandelier': '9.4', 'Lower rhombic lip': '8.8', 'Mammillary body': '8.8', 'Medium spiny neuron': '10.4', 'Mge interneuron': '10.7', 'Midbrain-derived inhibitory': '13.1', 'Miscellaneous': '8.4', 'Splatter': '9.0', 'Thalamic excitatory': '9.9', 'Upper rhombic lip': '11.9', 'Upper-layer intratelencephalic': '8.3', 'Astrocyte': '14.0', 'Bergmann glia': '10.1', 'Central nervous system macrophage': '17.1', 'Choroid plexus epithelial cell': '11.6', 'Committed oligodendrocyte precursor': '10.8', 'Ependymal cell': '8.7', 'Oligodendrocyte': '18.4', 'Oligodendrocyte precursor cell': '13.0', 'Endothelial cell': '12.6', 'Pericyte': '9.9', 'Vascular associated smooth muscle cell': '15.4', 'Fibroblast': '9.7', 'Leukocyte': '19.1', 'Basophil': '149.8', 'Eosinophil': '33.8', 'Neutrophil': '99.7', 'Classical monocyte': '42.2', 'Non-classical monocyte': '53.7', 'Intermediate monocyte': '166.6', 'T-reg': '265.1', 'GdT-cell': '46.8', 'MAIT T-cell': '258.4', 'Memory CD4 T-cell': '47.0', 'Naive CD4 T-cell': '122.3', 'Memory CD8 T-cell': '45.4', 'Naive CD8 T-cell': '109.0', 'Memory B-cell': '55.4', 'Naive B-cell': '132.3', 'Plasmacytoid DC': '288.6', 'Myeloid DC': '226.9', 'NK-cell': '93.5', 'Total PBMC': '188.3', 'Vd2 gdTCR': '242.0', 'Memory CD4 T-cell Th1\\/Th17': '88.9', 'Memory CD4 T-cell Th17': '80.6', 'Memory CD4 T-cell Th2': '88.0', 'Non-Vd2 gdTCR': '239.5', 'Memory CD4 T-cell Th1': '80.6', 'Memory CD4 T-cell TFH': '92.3', 'Terminal effector memory CD4 T-cell': '265.0', 'Central memory CD8 T-cell': '285.0', 'Effector memory CD8 T-cell': '257.8', 'Terminal effector memory CD8 T-cell': '241.2', 'Non-switched memory B-cell': '219.3', 'Plasmablast': '281.7', 'Switched memory B-cell': '225.6', 'Exhausted memory B-cell': '246.0', 'Progenitor cell': '226.9', 'Memory T-reg': '77.2', 'Naive CD4 T-cell activated': '142.2', 'Naive CD8 T-cell activated': '118.8', 'Naive T-reg': '129.1'}
1WF0, 2CQG, 2N2C, 2N3X, 2N4G, 2N4H, 2N4P, 4BS2, 4IUF, 4Y00, 4Y0F, 5MDI, 5MRG, 5W50, 5W52, 5W7V, 5WHN, 5WHP, 5WIA, 5WIQ, 5WKB, 5WKD, 5X4F, 6B1G, 6CF4, 6CFH, 6N37, 6N3A, 6N3B, 6N3C, 6T4B, 7KWZ, 7N9H, 7PY2, 7Q3U, 8A6I, 8CG3, 8CGG, 8CGH, 8QX9, 8QXA, 8QXB
{'Adipose Tissue': 67.26029900332226, 'Adrenal Gland': 50.162519379844966, 'Bladder': 82.68095238095238, 'Blood': 32.26520452099031, 'Blood Vessel': 91.93789513108614, 'Brain': 51.67061279333838, 'Breast': 76.86230936819173, 'Cervix Uteri': 103.7042105263158, 'Colon': 76.05160462130937, 'Esophagus': 75.26547404844291, 'Fallopian Tube': 98.24555555555555, 'Heart': 31.323357723577235, 'Kidney': 43.32393258426966, 'Liver': 36.73, 'Lung': 89.82359861591695, 'Muscle': 49.22470734744708, 'Nerve': 122.4886591276252, 'Ovary': 111.52177777777776, 'Pancreas': 27.166134146341463, 'Pituitary': 88.34802120141343, 'Prostate': 89.068, 'Salivary Gland': 66.94203703703704, 'Skin': 80.42339414040907, 'Small Intestine': 80.54112299465241, 'Spleen': 81.8197510373444, 'Stomach': 55.28699164345404, 'Testis': 74.93817174515236, 'Thyroid': 107.1800918836141, 'Uterus': 116.33577464788732, 'Vagina': 92.14884615384616}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
65.220676
0.616522
1,919
O60260
Q13155
16135753, PRKN2_HUMAN, E3NethUbiquitome
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
AIMP2
MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLFSLFGQKHNAVNATLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVVLWSVLQQIGGCSVTVPANVQRWMRSCENLAPFNTALKLLK
Homo sapiens
Cytoplasm, cytosol, Nucleus
Tissue enhanced (skeletal)
{'Ciliated cells': '25.1', 'Basal respiratory cells': '58.2', 'Club cells': '28.0', 'Ionocytes': '34.2', 'Mucus glandular cells': '12.2', 'Serous glandular cells': '20.6', 'Gastric mucus-secreting cells': '19.5', 'Proximal enterocytes': '60.7', 'Paneth cells': '18.0', 'Distal enterocytes': '30.4', 'Intestinal goblet cells': '18.3', 'Exocrine glandular cells': '-0.684', 'Basal prostatic cells': '13.6', 'Prostatic glandular cells': '11.6', 'Breast glandular cells': '-0.126', 'Breast myoepithelial cells': '-0.353', 'Glandular and luminal cells': '23.1', 'Secretory cells': '31.2', 'Basal keratinocytes': '20.3', 'Suprabasal keratinocytes': '24.3', 'Basal squamous epithelial cells': '28.4', 'Squamous epithelial cells': '35.8', 'Alveolar cells type 1': '-0.112', 'Alveolar cells type 2': '0.428', 'Salivary duct cells': '14.2', 'Ductal cells': '0.476', 'Hepatocytes': '0.506', 'Cholangiocytes': '30.5', 'Proximal tubular cells': '0.328', 'Distal tubular cells': '43.0', 'Collecting duct cells': '15.6', 'Mesothelial cells': '-0.147', 'Sertoli cells': '-0.428', 'Granulosa cells': '13.4', 'Enteroendocrine cells': '26.9', 'Pancreatic endocrine cells': '39.1', 'Leydig cells': '-0.457', 'Excitatory neurons': '5.6', 'Inhibitory neurons': '6.4', 'Cone photoreceptor cells': '13.6', 'Rod photoreceptor cells': '9.2', 'Bipolar cells': '10.4', 'Horizontal cells': '6.9', 'Astrocytes': '7.7', 'Oligodendrocyte precursor cells': '4.7', 'Oligodendrocytes': '9.7', 'Microglial cells': '1.8', 'Muller glia cells': '16.0', 'Schwann cells': '-0.008', 'Spermatogonia': '-0.129', 'Spermatocytes': '0.211', 'Early spermatids': '0.845', 'Late spermatids': '0.571', 'Oocytes': '139.7', 'Cytotrophoblasts': '56.2', 'Syncytiotrophoblasts': '43.4', 'Extravillous trophoblasts': '65.0', 'Endothelial cells': '18.5', 'Lymphatic endothelial cells': '15.3', 'Cardiomyocytes': '0.734', 'Skeletal myocytes': '0.052', 'Smooth muscle cells': '17.7', 'Adipocytes': '14.0', 'Melanocytes': '0.265', 'Fibroblasts': '18.4', 'Peritubular cells': '-0.364', 'Endometrial stromal cells': '25.0', 'Ovarian stromal cells': '9.6', 'Undifferentiated cells': '44.0', 'T-cells': '10.3', 'B-cells': '10.0', 'Plasma cells': '26.4', 'Nk-cells': '11.8', 'Granulocytes': '18.3', 'Monocytes': '17.1', 'Macrophages': '18.5', 'Hofbauer cells': '45.8', 'Kupffer cells': '17.0', 'Dendritic cells': '7.4', 'Langerhans cells': '0.300', 'Erythroid cells': '-0.067', 'Adipocytes (Subcutaneous)': '0.315', 'Adipocytes (Visceral)': '0.379', 'Breast glandular cells (progenitors)': '-0.216', 'Adipocytes (Breast)': '0.434', 'Colon enterocytes': '0.096', 'Colon enteroendocrine cells': '-0.025', 'Enteric glia cells': '-0.594', 'Mitotic cells (Colon)': '0.106', 'Mitotic cells (Heart)': '0.420', 'Podocytes': '-0.069', 'Ascending Loop of Henle cells': '0.337', 'Intercalated cells': '0.068', 'Cholangiocyte': '0.252', 'NK-cells (Liver)': '-0.328', 'Respiratory ciliated cells': '-0.130', 'Mitotic cells (Lung)': '0.192', 'NK-cells (Lung)': '-0.373', 'B-cells (Lung)': '-0.310', 'Alpha cells': '0.336', 'Beta cells': '0.165', 'Prostate glandular cells': '-0.027', 'Prostate basal glandular cells': '0.143', 'Urothelial cells': '-0.047', 'Keratinocyte (other)': '0.409', 'Keratinocyte (granular)': '0.028', 'Hair cortex cells': '0.053', 'Inner root sheath cells': '0.087', 'Outer root sheath cells': '0.024', 'Sebaceous gland cells': '0.118', 'Eccrine sweat gland cells': '-0.214', 'Adipocytes (Skin)': '-0.219', 'Mitotic cells (Skin)': '0.289', 'Parietal cells': '-0.410', 'Chief cells': '-0.393', 'Gastric mucous cells': '-0.110', 'Gastric enteroendocrine cells': '-0.331', 'Mitotic cells (Stomach)': '0.293', 'Parafollicular cells': '0.069', 'Thyroid glandular cells': '0.404', 'Mitotic cells (Thyroid)': '-0.104', 'Adrenal cortex cells': '0.574', 'Adrenal medulla cells': '0.026', 'Mitotic cells (Adrenal gland)': '0.451', 'Minor salivary glandular cells': '0.255', 'Minor salivary gland ductal cells': '-0.232', 'Minor salivary gland basal cells': '0.506', 'Mitotic cells (Minor salivary gland)': '0.604', 'Adipocytes (Minor salivary gland)': '0.252', 'Somatotropes': '-0.198', 'Lactotropes': '-0.132', 'Gonadotropes': '-0.062', 'Corticotropes': '-0.049', 'Thyrotropes': '0.094', 'Undifferentiated cells (Pituitary gland)': '0.390', 'Mitotic cells (Spleen)': '0.037', 'Platelets': '0.091', 'Erythrocytes': '-0.124', 'Hematopoietic stem cells': '0.048', 'B-cells (Spleen)': '0.077', 'NK-cells (Spleen)': '-0.095', 'Amygdala excitatory': '9.1', 'Cerebellar inhibitory': '18.0', 'Cge interneuron': '13.0', 'Deep-layer corticothalamic and 6b': '11.4', 'Deep-layer intratelencephalic': '11.5', 'Deep-layer near-projecting': '12.4', 'Eccentric medium spiny neuron': '11.2', 'Hippocampal ca1-3': '12.6', 'Hippocampal ca4': '18.2', 'Hippocampal dentate gyrus': '12.4', 'Lamp5-lhx6 and chandelier': '14.6', 'Lower rhombic lip': '16.1', 'Mammillary body': '13.1', 'Medium spiny neuron': '12.7', 'Mge interneuron': '11.9', 'Midbrain-derived inhibitory': '10.8', 'Miscellaneous': '10.8', 'Splatter': '12.1', 'Thalamic excitatory': '12.1', 'Upper rhombic lip': '14.1', 'Upper-layer intratelencephalic': '9.9', 'Astrocyte': '14.1', 'Bergmann glia': '19.6', 'Central nervous system macrophage': '16.2', 'Choroid plexus epithelial cell': '17.4', 'Committed oligodendrocyte precursor': '13.6', 'Ependymal cell': '10.9', 'Oligodendrocyte': '21.7', 'Oligodendrocyte precursor cell': '12.9', 'Endothelial cell': '11.9', 'Pericyte': '17.5', 'Vascular associated smooth muscle cell': '10.0', 'Fibroblast': '10.8', 'Leukocyte': '6.9', 'Basophil': '14.6', 'Eosinophil': '21.3', 'Neutrophil': '5.8', 'Classical monocyte': '8.8', 'Non-classical monocyte': '9.5', 'Intermediate monocyte': '46.2', 'T-reg': '20.0', 'GdT-cell': '42.8', 'MAIT T-cell': '18.6', 'Memory CD4 T-cell': '28.6', 'Naive CD4 T-cell': '6.1', 'Memory CD8 T-cell': '33.7', 'Naive CD8 T-cell': '6.7', 'Memory B-cell': '48.8', 'Naive B-cell': '4.6', 'Plasmacytoid DC': '49.2', 'Myeloid DC': '62.8', 'NK-cell': '8.2', 'Total PBMC': '41.0', 'Vd2 gdTCR': '21.5', 'Memory CD4 T-cell Th1\\/Th17': '5.5', 'Memory CD4 T-cell Th17': '7.0', 'Memory CD4 T-cell Th2': '6.7', 'Non-Vd2 gdTCR': '18.4', 'Memory CD4 T-cell Th1': '6.5', 'Memory CD4 T-cell TFH': '8.3', 'Terminal effector memory CD4 T-cell': '19.0', 'Central memory CD8 T-cell': '17.9', 'Effector memory CD8 T-cell': '18.0', 'Terminal effector memory CD8 T-cell': '19.6', 'Non-switched memory B-cell': '20.6', 'Plasmablast': '50.5', 'Switched memory B-cell': '29.6', 'Exhausted memory B-cell': '20.9', 'Progenitor cell': '29.6', 'Memory T-reg': '9.4', 'Naive CD4 T-cell activated': '41.9', 'Naive CD8 T-cell activated': '42.5', 'Naive T-reg': '7.7'}
4DPG, 4YCU, 4YCW, 5A1N, 5A34, 5A5H, 5Y6L, 6ILD, 6IY6, 6JPV, 6K39, 8J9S
{'Adipose Tissue': 16.500236710963456, 'Adrenal Gland': 16.309240310077517, 'Bladder': 16.57147619047619, 'Blood': 10.189565016146394, 'Blood Vessel': 14.8048202247191, 'Brain': 7.308502725208176, 'Breast': 16.444690631808278, 'Cervix Uteri': 13.27442105263158, 'Colon': 16.894408215661105, 'Esophagus': 15.49868373702422, 'Fallopian Tube': 15.843555555555556, 'Heart': 12.762181649245065, 'Kidney': 11.983202247191011, 'Liver': 11.061557522123891, 'Lung': 14.254520761245674, 'Muscle': 55.23566625155666, 'Nerve': 16.237119547657514, 'Ovary': 9.415838888888889, 'Pancreas': 5.550375, 'Pituitary': 8.618893992932861, 'Prostate': 11.393204081632652, 'Salivary Gland': 14.38675925925926, 'Skin': 24.309268656716416, 'Small Intestine': 16.368229946524064, 'Spleen': 11.67633609958506, 'Stomach': 11.18431754874652, 'Testis': 44.67119113573407, 'Thyroid': 19.86671975497703, 'Uterus': 15.662957746478872, 'Vagina': 14.259320512820514}
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[46.28, 59.51, 57.55, 70.39, 63.0, 69.98, 65.82, 64.65, 63.95, 60.14, 49.77, 49.36, 57.45, 60.37, 62.42, 62.47, 61.23, 66.96, 68.32, 67.7, 63.68, 68.02, 68.38, 62.48, 69.65, 66.46, 64.38, 65.17, 63.64, 69.63, 65.42, 53.18, 45.89, 47.61, 44.57, 41.88, 38.29, 41.11, 40.63, 40.22, 38.24, 39.11, 45.42, 52.85, 49.61, 51.93, 54.76, 59.8, 75.26, 81.49, 81.94, 81.86, 85.16, 86.56, 86.45, 88.97, 89.1, 91.76, 93.43, 92.51, 92.59, 92.17, 92.7, 93.34, 91.48, 92.84, 92.23, 93.35, 91.62, 93.5, 92.19, 89.85, 90.62, 88.28, 84.6, 85.03, 80.72, 79.11, 71.62, 71.79, 59.69, 50.04, 43.77, 42.56, 47.61, 39.78, 52.25, 40.85, 50.62, 44.34, 41.79, 45.15, 40.97, 36.53, 34.7, 37.33, 36.53, 37.19, 33.79, 36.16, 49.6, 33.94, 31.64, 37.62, 45.99, 56.32, 71.93, 77.19, 76.37, 76.98, 78.51, 77.48, 71.63, 64.17, 60.79, 56.77, 58.85, 60.72, 65.1, 80.05, 87.78, 91.96, 94.22, 97.04, 96.85, 97.83, 96.69, 95.94, 93.69, 93.45, 95.29, 96.28, 96.72, 97.75, 97.75, 97.18, 97.66, 97.83, 96.91, 95.55, 96.31, 94.99, 93.81, 93.46, 91.1, 90.96, 90.54, 92.05, 92.47, 93.84, 93.71, 95.3, 95.18, 96.45, 96.92, 96.28, 96.27, 95.45, 91.57, 90.99, 93.55, 93.41, 92.28, 92.96, 94.09, 92.78, 91.98, 92.18, 90.7, 82.79, 68.17, 63.09, 54.6, 63.99, 64.51, 72.83, 77.08, 78.72, 76.69, 82.61, 86.62, 87.42, 89.71, 90.81, 93.93, 94.73, 96.86, 96.74, 98.02, 97.53, 96.82, 96.15, 94.85, 95.32, 97.06, 96.1, 95.08, 89.61, 78.17, 69.77, 62.26, 64.18, 65.48, 71.92, 79.59, 87.77, 92.54, 95.6, 95.69, 97.04, 97.72, 97.13, 97.48, 98.22, 97.52, 94.62, 95.81, 96.12, 94.01, 92.24, 91.75, 87.72, 85.43, 89.29, 91.84, 94.91, 96.37, 97.24, 96.32, 97.02, 97.9, 98.04, 98.42, 98.33, 98.31, 98.6, 98.53, 98.05, 97.88, 97.48, 96.2, 94.98, 94.08, 93.89, 93.04, 88.69, 90.14, 91.74, 90.86, 92.62, 93.53, 94.49, 93.26, 95.33, 96.39, 95.77, 96.69, 97.56, 97.96, 97.85, 98.1, 98.11, 98.39, 97.69, 97.53, 97.52, 97.27, 98.33, 97.94, 97.01, 95.21, 95.64, 95.25, 96.99, 98.01, 98.31, 98.5, 98.57, 98.47, 98.43, 97.65, 97.41, 96.89, 95.65, 94.26, 93.39, 90.98, 87.03, 69.2, 60.49, 58.66, 68.12, 79.3, 88.18, 91.84, 95.24, 96.79, 98.03, 96.9, 95.52, 97.5, 98.29, 96.25, 96.55, 97.5, 97.5, 94.74, 96.19, 96.47, 95.31, 95.89, 96.79, 93.95, 92.67, 93.68, 92.64, 90.45, 84.68, 82.8, 72.5]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
81.255219
0.472688
2,303
O60260
Q13263
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
TRIM28
MAASAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCKQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSRDGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLNAWTKSAEAFGKIVAERPGTNSTGPAPMAPPRAPGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKRSRSGEGEVSGLMRKVPRVSLERLDLDLTADSQPPVFKVFPGSTTEDYNLIVIERGAAAAATGQPGTAPAGTPGAPPLAGMAIVKEEETEAAIGAPPTATEGPETKPVLMALAEGPGAEGPRLASPSGSTSSGLEVVAPEGTSAPGGGPGTLDDSATICRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPGEEWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTEDKADVQSIIGLQRFFETRMNEAFGDTKFSAVLVEPPPMSLPGAGLSSQELSGGPGDGP
Homo sapiens
Nucleus
Low tissue specificity
{'Ciliated cells': '56.4', 'Basal respiratory cells': '33.8', 'Club cells': '47.1', 'Ionocytes': '37.2', 'Mucus glandular cells': '40.5', 'Serous glandular cells': '54.9', 'Gastric mucus-secreting cells': '62.5', 'Proximal enterocytes': '39.2', 'Paneth cells': '48.2', 'Distal enterocytes': '56.9', 'Intestinal goblet cells': '58.0', 'Exocrine glandular cells': '-0.739', 'Basal prostatic cells': '58.3', 'Prostatic glandular cells': '41.7', 'Breast glandular cells': '0.550', 'Breast myoepithelial cells': '0.330', 'Glandular and luminal cells': '78.6', 'Secretory cells': '75.2', 'Basal keratinocytes': '72.9', 'Suprabasal keratinocytes': '71.3', 'Basal squamous epithelial cells': '50.5', 'Squamous epithelial cells': '54.1', 'Alveolar cells type 1': '0.006', 'Alveolar cells type 2': '-0.065', 'Salivary duct cells': '50.3', 'Ductal cells': '0.459', 'Hepatocytes': '0.383', 'Cholangiocytes': '42.0', 'Proximal tubular cells': '0.157', 'Distal tubular cells': '12.3', 'Collecting duct cells': '25.3', 'Mesothelial cells': '0.355', 'Sertoli cells': '-0.214', 'Granulosa cells': '61.5', 'Enteroendocrine cells': '58.8', 'Pancreatic endocrine cells': '57.7', 'Leydig cells': '-0.303', 'Excitatory neurons': '9.9', 'Inhibitory neurons': '12.1', 'Cone photoreceptor cells': '22.1', 'Rod photoreceptor cells': '30.1', 'Bipolar cells': '63.6', 'Horizontal cells': '46.6', 'Astrocytes': '17.3', 'Oligodendrocyte precursor cells': '9.9', 'Oligodendrocytes': '16.9', 'Microglial cells': '6.3', 'Muller glia cells': '46.4', 'Schwann cells': '0.002', 'Spermatogonia': '0.076', 'Spermatocytes': '0.344', 'Early spermatids': '0.492', 'Late spermatids': '0.248', 'Oocytes': '52.2', 'Cytotrophoblasts': '62.1', 'Syncytiotrophoblasts': '55.1', 'Extravillous trophoblasts': '60.1', 'Endothelial cells': '49.6', 'Lymphatic endothelial cells': '35.1', 'Cardiomyocytes': '0.539', 'Skeletal myocytes': '-0.223', 'Smooth muscle cells': '61.2', 'Adipocytes': '54.5', 'Melanocytes': '0.080', 'Fibroblasts': '44.6', 'Peritubular cells': '-0.206', 'Endometrial stromal cells': '50.7', 'Ovarian stromal cells': '66.3', 'Undifferentiated cells': '85.5', 'T-cells': '53.7', 'B-cells': '47.9', 'Plasma cells': '55.8', 'Nk-cells': '43.4', 'Granulocytes': '42.9', 'Monocytes': '78.9', 'Macrophages': '54.5', 'Hofbauer cells': '46.0', 'Kupffer cells': '40.7', 'Dendritic cells': '62.6', 'Langerhans cells': '0.135', 'Erythroid cells': '-0.054', 'Adipocytes (Subcutaneous)': '-0.223', 'Adipocytes (Visceral)': '-0.139', 'Breast glandular cells (progenitors)': '0.496', 'Adipocytes (Breast)': '-0.326', 'Colon enterocytes': '-0.165', 'Colon enteroendocrine cells': '0.099', 'Enteric glia cells': '-0.039', 'Mitotic cells (Colon)': '-0.255', 'Mitotic cells (Heart)': '0.468', 'Podocytes': '-0.127', 'Ascending Loop of Henle cells': '0.461', 'Intercalated cells': '-0.051', 'Cholangiocyte': '0.337', 'NK-cells (Liver)': '-0.265', 'Respiratory ciliated cells': '-0.019', 'Mitotic cells (Lung)': '0.019', 'NK-cells (Lung)': '0.006', 'B-cells (Lung)': '-0.127', 'Alpha cells': '0.308', 'Beta cells': '0.172', 'Prostate glandular cells': '-0.069', 'Prostate basal glandular cells': '0.302', 'Urothelial cells': '0.242', 'Keratinocyte (other)': '0.160', 'Keratinocyte (granular)': '0.221', 'Hair cortex cells': '-0.006', 'Inner root sheath cells': '0.053', 'Outer root sheath cells': '-0.093', 'Sebaceous gland cells': '-0.047', 'Eccrine sweat gland cells': '-0.333', 'Adipocytes (Skin)': '-0.161', 'Mitotic cells (Skin)': '-0.039', 'Parietal cells': '-0.642', 'Chief cells': '-0.441', 'Gastric mucous cells': '-0.328', 'Gastric enteroendocrine cells': '-0.352', 'Mitotic cells (Stomach)': '0.123', 'Parafollicular cells': '0.082', 'Thyroid glandular cells': '0.334', 'Mitotic cells (Thyroid)': '-0.070', 'Adrenal cortex cells': '0.453', 'Adrenal medulla cells': '-0.018', 'Mitotic cells (Adrenal gland)': '0.101', 'Minor salivary glandular cells': '0.471', 'Minor salivary gland ductal cells': '-0.029', 'Minor salivary gland basal cells': '0.433', 'Mitotic cells (Minor salivary gland)': '0.449', 'Adipocytes (Minor salivary gland)': '0.142', 'Somatotropes': '0.158', 'Lactotropes': '0.166', 'Gonadotropes': '-0.012', 'Corticotropes': '0.050', 'Thyrotropes': '0.186', 'Undifferentiated cells (Pituitary gland)': '0.096', 'Mitotic cells (Spleen)': '-0.118', 'Platelets': '-0.163', 'Erythrocytes': '-0.086', 'Hematopoietic stem cells': '-0.281', 'B-cells (Spleen)': '0.439', 'NK-cells (Spleen)': '0.145', 'Amygdala excitatory': '14.5', 'Cerebellar inhibitory': '20.2', 'Cge interneuron': '23.5', 'Deep-layer corticothalamic and 6b': '14.1', 'Deep-layer intratelencephalic': '14.5', 'Deep-layer near-projecting': '15.5', 'Eccentric medium spiny neuron': '18.6', 'Hippocampal ca1-3': '15.5', 'Hippocampal ca4': '14.9', 'Hippocampal dentate gyrus': '14.2', 'Lamp5-lhx6 and chandelier': '21.2', 'Lower rhombic lip': '13.8', 'Mammillary body': '10.8', 'Medium spiny neuron': '15.5', 'Mge interneuron': '17.3', 'Midbrain-derived inhibitory': '21.7', 'Miscellaneous': '15.9', 'Splatter': '17.1', 'Thalamic excitatory': '17.6', 'Upper rhombic lip': '29.0', 'Upper-layer intratelencephalic': '12.6', 'Astrocyte': '26.0', 'Bergmann glia': '20.0', 'Central nervous system macrophage': '24.6', 'Choroid plexus epithelial cell': '25.3', 'Committed oligodendrocyte precursor': '36.7', 'Ependymal cell': '31.4', 'Oligodendrocyte': '27.5', 'Oligodendrocyte precursor cell': '26.9', 'Endothelial cell': '30.9', 'Pericyte': '46.0', 'Vascular associated smooth muscle cell': '40.8', 'Fibroblast': '25.5', 'Leukocyte': '31.1', 'Basophil': '10.2', 'Eosinophil': '8.2', 'Neutrophil': '21.4', 'Classical monocyte': '82.9', 'Non-classical monocyte': '92.5', 'Intermediate monocyte': '42.5', 'T-reg': '33.8', 'GdT-cell': '12.8', 'MAIT T-cell': '36.5', 'Memory CD4 T-cell': '18.0', 'Naive CD4 T-cell': '160.9', 'Memory CD8 T-cell': '17.4', 'Naive CD8 T-cell': '209.2', 'Memory B-cell': '16.0', 'Naive B-cell': '130.0', 'Plasmacytoid DC': '40.2', 'Myeloid DC': '52.6', 'NK-cell': '147.7', 'Total PBMC': '34.9', 'Vd2 gdTCR': '34.7', 'Memory CD4 T-cell Th1\\/Th17': '132.6', 'Memory CD4 T-cell Th17': '169.9', 'Memory CD4 T-cell Th2': '176.4', 'Non-Vd2 gdTCR': '34.1', 'Memory CD4 T-cell Th1': '184.8', 'Memory CD4 T-cell TFH': '232.0', 'Terminal effector memory CD4 T-cell': '36.0', 'Central memory CD8 T-cell': '23.8', 'Effector memory CD8 T-cell': '30.4', 'Terminal effector memory CD8 T-cell': '24.5', 'Non-switched memory B-cell': '30.8', 'Plasmablast': '43.0', 'Switched memory B-cell': '36.5', 'Exhausted memory B-cell': '26.0', 'Progenitor cell': '41.4', 'Memory T-reg': '184.6', 'Naive CD4 T-cell activated': '318.1', 'Naive CD8 T-cell activated': '359.0', 'Naive T-reg': '190.5'}
1FP0, 2RO1, 2YVR, 6H3A, 6I9H, 6QAJ, 6QU1, 7Z36
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[1.0, 1.0, 1.0, 1.0, 0.99, 0.99, 0.98, 1.0, 0.98, 1.0, 1.0, 0.99, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.99, 1.0, 0.98, 0.99, 0.96, 0.94, 0.83, 0.84, 0.78, 0.84, 0.8, 0.79, 0.85, 0.76, 0.79, 0.74, 0.59, 0.4, 0.47, 0.57, 0.62, 0.59, 0.68, 0.59, 0.61, 0.63, 0.33, 0.23, 0.02, 0.45, 0.47, 0.45, 0.76, 0.43, 0.37, 0.03, 0.52, 0.41, 0.8, 0.46, 0.51, 0.03, 0.3, 0.26, 0.04, 0.47, 0.17, 0.68, 0.33, 0.12, 0.03, 0.07, 0.28, 0.84, 0.32, 0.21, 0.61, 0.95, 0.33, 0.84, 0.92, 0.84, 0.76, 0.9, 0.86, 0.95, 1.0, 0.88, 1.0, 0.98, 0.89, 0.99, 0.85, 0.89, 0.74, 0.31, 0.4, 0.49, 0.12, 0.57, 0.01, 0.33, 0.53, 0.45, 0.69, 0.52, 0.74, 0.04, 0.56, 0.34, 0.7, 0.51, 0.18, 0.5, 0.32, 0.06, 0.48, 0.81, 0.07, 0.39, 0.47, 0.25, 0.63, 0.85, 0.58, 0.99, 0.93, 0.73, 0.55, 0.86, 0.89, 0.67, 0.79, 0.88, 0.43, 0.44, 0.04, 0.57, 0.55, 0.19, 0.92, 0.84, 0.62, 0.28, 0.74, 0.13, 0.35, 0.08, 0.36, 0.0, 0.43, 0.52, 0.32, 0.57, 0.35, 0.15, 0.01, 0.05, 0.7, 0.66, 0.13, 0.12, 0.51, 0.39, 0.11, 0.51, 0.68, 0.51, 0.9, 0.86, 0.17, 0.64, 0.88, 0.26, 0.46, 0.29, 0.63, 0.7, 0.44, 0.45, 0.94, 0.67, 0.93, 0.58, 0.92, 0.86, 0.67, 0.82, 0.78, 0.31, 0.33, 0.48, 0.08, 0.87, 0.83, 0.26, 0.75, 0.87, 0.39, 0.29, 0.23, 0.51, 0.15, 0.22, 0.0, 0.42, 0.58, 0.4, 0.69, 0.45, 0.49, 0.02, 0.0, 0.63, 0.33, 0.1, 0.11, 0.62, 0.68, 0.77, 0.19, 0.68, 0.94, 0.37, 0.64, 0.55, 0.29, 0.59, 0.33, 0.78, 0.35, 0.15, 0.36, 0.59, 0.47, 0.47, 0.69, 0.61, 0.55, 0.5, 0.53, 0.41, 0.44, 0.67, 0.63, 0.6, 0.65, 0.45, 0.45, 0.69, 0.59, 0.54, 0.59, 0.61, 0.53, 0.6, 0.41, 0.41, 0.62, 0.51, 0.52, 0.65, 0.56, 0.45, 0.63, 0.7, 0.65, 0.62, 0.42, 0.52, 0.52, 0.7, 0.52, 0.68, 0.53, 0.6, 0.54, 0.52, 0.52, 0.56, 0.56, 0.42, 0.5, 0.63, 0.65, 0.62, 0.5, 0.72, 0.37, 0.36, 0.52, 0.5, 0.2, 0.27, 0.63, 0.45, 0.06, 0.64, 0.47, 0.33, 0.24, 0.53, 0.54, 0.33, 0.47, 0.48, 0.34, 0.3, 0.53, 0.49, 0.48, 0.37, 0.54, 0.55, 0.28, 0.64, 0.66, 0.49, 0.42, 0.3, 0.61, 0.13, 0.55, 0.61, 0.4, 0.32, 0.36, 0.54, 0.11, 0.59, 0.58, 0.45, 0.12, 0.44, 0.61, 0.11, 0.75, 0.78, 0.33, 0.84, 0.51, 0.6, 0.63, 0.4, 0.32, 0.62, 0.77, 0.34, 0.56, 0.83, 0.7, 0.17, 0.65, 0.67, 0.43, 0.31, 0.42, 0.55, 0.14, 0.79, 0.7, 0.41, 0.85, 0.47, 0.85, 0.84, 0.54, 0.57, 0.72, 0.57, 0.25, 0.57, 0.42, 0.29, 0.52, 0.51, 0.56, 0.56, 0.65, 0.72, 0.25, 0.38, 0.81, 0.86, 0.39, 0.28, 0.74, 0.43, 0.22, 0.12, 0.65, 0.24, 0.26, 0.51, 0.43, 0.68, 0.53, 0.87, 0.84, 0.96, 0.85, 0.98, 0.82, 0.96, 0.94, 0.94, 0.94, 0.95, 0.94, 0.96, 0.97, 0.95, 0.93, 1.0, 0.99, 0.98, 0.99, 0.98, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.99, 1.0, 0.87, 1.0, 0.91, 1.0, 0.96, 1.0, 0.93, 1.0, 1.0, 1.0, 1.0, 0.94, 1.0, 0.83, 0.99, 0.97, 0.96, 0.98, 0.97, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.99, 0.85, 0.92, 0.86, 0.9, 0.92, 0.91, 0.88, 0.75, 0.94, 0.79, 0.77, 0.86, 0.85, 0.85, 0.5, 0.63, 0.4, 0.77, 0.75, 0.62, 0.98, 0.9, 0.34, 0.74, 0.74, 0.18, 0.45, 0.59, 0.36, 0.6, 0.5, 0.83, 0.32, 0.86, 0.62, 0.99, 0.86, 0.44, 0.83, 0.61, 0.59, 0.62, 0.33, 0.47, 0.43, 0.7, 0.41, 0.85, 0.8, 0.87, 0.84, 0.91, 0.94, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.99, 0.96, 1.0, 0.78, 1.0, 0.78, 0.95, 0.95, 0.93, 0.98, 0.98, 1.0, 0.96, 0.99, 0.96, 0.99, 0.99, 0.96, 0.99, 0.98, 0.97, 0.93, 0.82, 0.9, 0.77, 0.92, 0.78, 0.89, 0.89, 0.85, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.95, 0.96, 0.93, 0.93, 0.96, 0.97, 0.98, 0.97, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.93, 0.88, 0.94, 0.72, 0.76, 0.56, 0.57, 0.62, 0.33, 0.0, 0.28, 0.13, 0.37, 0.42, 0.65, 0.73, 0.67, 0.81, 0.3, 0.09, 0.53, 0.0, 0.54, 0.69, 0.26, 0.66, 0.33, 0.05, 0.0, 0.2, 0.25, 0.73, 0.17, 0.05, 0.01, 0.52, 0.36, 0.19, 0.93, 0.79, 0.82, 0.29, 0.74, 0.89, 0.94, 0.16, 0.34, 0.0, 0.21, 0.26, 0.21, 0.57, 0.86, 0.41, 0.78, 0.89, 0.84, 0.87, 0.92, 0.89, 0.88, 0.82, 0.9, 0.98, 0.99, 1.0, 0.97, 1.0, 0.99, 1.0, 0.99, 0.93, 0.89, 0.92, 0.6, 0.58, 0.56, 0.14, 0.47, 0.72, 0.55, 0.27, 0.22, 0.61, 0.27, 0.0, 0.11, 0.34, 0.03, 0.0, 0.0, 0.11, 0.01, 0.1, 0.12, 0.25, 0.54, 0.29, 0.02, 0.29, 0.45, 0.04, 0.28, 0.71, 0.51, 0.4, 0.65, 0.66, 0.83, 0.83, 0.76, 0.78, 0.97, 0.91, 0.84, 0.98, 0.84, 0.72, 0.48, 0.19, 0.21, 0.02, 0.67, 0.41, 0.0, 0.2, 0.2, 0.16, 0.02, 0.22, 0.51, 0.7, 0.37, 0.96, 0.6, 0.15, 0.01, 0.47, 0.35, 0.09, 0.52, 0.25, 0.0, 0.02, 0.39, 0.07, 0.0, 0.04, 0.56, 0.01, 0.04, 0.4, 0.31, 0.07, 0.48, 0.87, 0.6, 0.17, 0.94, 0.47, 0.74, 0.54, 0.41, 0.26, 0.64, 0.36, 0.05, 0.45, 0.41, 0.01, 0.29, 0.64, 0.18, 0.02, 0.32, 0.53, 0.36, 0.02, 0.41, 0.59, 0.21, 0.18, 0.44, 0.82, 0.47, 0.81, 0.11, 0.51, 0.61, 0.26, 0.14, 0.8, 0.76, 0.95, 0.86, 0.86, 0.91, 0.83, 0.91, 0.94, 0.89, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
65.000551
0.633617
748
O60260
Q13501
26746706, 23503661
UbiNet, UbiBrowser, 31181401, DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
SQSTM1
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL
Homo sapiens
Cytoplasmic vesicle, autophagosome, Preautophagosomal structure, Cytoplasm, cytosol, Nucleus, PML body, Late endosome, Lysosome, Nucleus, Endoplasmic reticulum, Cytoplasm, myofibril, sarcomere
Tissue enhanced (skeletal)
{'Ciliated cells': '254.9', 'Basal respiratory cells': '303.5', 'Club cells': '412.8', 'Ionocytes': '327.7', 'Mucus glandular cells': '545.4', 'Serous glandular cells': '241.1', 'Gastric mucus-secreting cells': '1156.1', 'Proximal enterocytes': '298.5', 'Paneth cells': '389.6', 'Distal enterocytes': '395.5', 'Intestinal goblet cells': '288.5', 'Exocrine glandular cells': '-0.553', 'Basal prostatic cells': '429.7', 'Prostatic glandular cells': '228.8', 'Breast glandular cells': '0.084', 'Breast myoepithelial cells': '0.100', 'Glandular and luminal cells': '559.1', 'Secretory cells': '266.7', 'Basal keratinocytes': '312.1', 'Suprabasal keratinocytes': '293.1', 'Basal squamous epithelial cells': '667.0', 'Squamous epithelial cells': '548.4', 'Alveolar cells type 1': '0.049', 'Alveolar cells type 2': '0.349', 'Salivary duct cells': '492.8', 'Ductal cells': '0.475', 'Hepatocytes': '0.458', 'Cholangiocytes': '299.5', 'Proximal tubular cells': '0.363', 'Distal tubular cells': '199.8', 'Collecting duct cells': '149.8', 'Mesothelial cells': '0.235', 'Sertoli cells': '0.501', 'Granulosa cells': '206.8', 'Enteroendocrine cells': '276.7', 'Pancreatic endocrine cells': '708.1', 'Leydig cells': '0.615', 'Excitatory neurons': '34.0', 'Inhibitory neurons': '35.6', 'Cone photoreceptor cells': '52.7', 'Rod photoreceptor cells': '66.0', 'Bipolar cells': '75.2', 'Horizontal cells': '66.1', 'Astrocytes': '35.0', 'Oligodendrocyte precursor cells': '15.6', 'Oligodendrocytes': '57.9', 'Microglial cells': '26.8', 'Muller glia cells': '140.9', 'Schwann cells': '0.000', 'Spermatogonia': '0.572', 'Spermatocytes': '0.178', 'Early spermatids': '-0.467', 'Late spermatids': '-0.596', 'Oocytes': '155.1', 'Cytotrophoblasts': '251.1', 'Syncytiotrophoblasts': '2518.9', 'Extravillous trophoblasts': '140.8', 'Endothelial cells': '266.9', 'Lymphatic endothelial cells': '277.6', 'Cardiomyocytes': '0.690', 'Skeletal myocytes': '-0.315', 'Smooth muscle cells': '271.4', 'Adipocytes': '375.3', 'Melanocytes': '-0.136', 'Fibroblasts': '407.1', 'Peritubular cells': '0.482', 'Endometrial stromal cells': '232.0', 'Ovarian stromal cells': '281.7', 'Undifferentiated cells': '142.4', 'T-cells': '238.5', 'B-cells': '255.1', 'Plasma cells': '481.3', 'Nk-cells': '241.5', 'Granulocytes': '709.7', 'Monocytes': '347.3', 'Macrophages': '391.1', 'Hofbauer cells': '276.8', 'Kupffer cells': '137.8', 'Dendritic cells': '178.7', 'Langerhans cells': '0.070', 'Erythroid cells': '-0.027', 'Adipocytes (Subcutaneous)': '0.147', 'Adipocytes (Visceral)': '-0.005', 'Breast glandular cells (progenitors)': '0.135', 'Adipocytes (Breast)': '-0.051', 'Colon enterocytes': '-0.073', 'Colon enteroendocrine cells': '0.157', 'Enteric glia cells': '-0.333', 'Mitotic cells (Colon)': '-0.049', 'Mitotic cells (Heart)': '0.414', 'Podocytes': '-0.044', 'Ascending Loop of Henle cells': '0.216', 'Intercalated cells': '-0.050', 'Cholangiocyte': '0.428', 'NK-cells (Liver)': '-0.358', 'Respiratory ciliated cells': '-0.133', 'Mitotic cells (Lung)': '0.079', 'NK-cells (Lung)': '-0.263', 'B-cells (Lung)': '-0.225', 'Alpha cells': '0.245', 'Beta cells': '0.081', 'Prostate glandular cells': '-0.065', 'Prostate basal glandular cells': '0.191', 'Urothelial cells': '0.064', 'Keratinocyte (other)': '-0.136', 'Keratinocyte (granular)': '-0.016', 'Hair cortex cells': '0.016', 'Inner root sheath cells': '0.014', 'Outer root sheath cells': '0.057', 'Sebaceous gland cells': '-0.005', 'Eccrine sweat gland cells': '0.190', 'Adipocytes (Skin)': '0.228', 'Mitotic cells (Skin)': '-0.025', 'Parietal cells': '-0.463', 'Chief cells': '-0.419', 'Gastric mucous cells': '-0.164', 'Gastric enteroendocrine cells': '-0.349', 'Mitotic cells (Stomach)': '0.114', 'Parafollicular cells': '0.106', 'Thyroid glandular cells': '0.349', 'Mitotic cells (Thyroid)': '-0.074', 'Adrenal cortex cells': '0.657', 'Adrenal medulla cells': '-0.038', 'Mitotic cells (Adrenal gland)': '0.490', 'Minor salivary glandular cells': '0.763', 'Minor salivary gland ductal cells': '0.010', 'Minor salivary gland basal cells': '0.055', 'Mitotic cells (Minor salivary gland)': '0.269', 'Adipocytes (Minor salivary gland)': '0.166', 'Somatotropes': '-0.163', 'Lactotropes': '-0.239', 'Gonadotropes': '-0.067', 'Corticotropes': '-0.191', 'Thyrotropes': '-0.068', 'Undifferentiated cells (Pituitary gland)': '0.342', 'Mitotic cells (Spleen)': '-0.273', 'Platelets': '-0.106', 'Erythrocytes': '-0.220', 'Hematopoietic stem cells': '-0.160', 'B-cells (Spleen)': '0.155', 'NK-cells (Spleen)': '0.050', 'Amygdala excitatory': '59.2', 'Cerebellar inhibitory': '65.2', 'Cge interneuron': '73.1', 'Deep-layer corticothalamic and 6b': '65.6', 'Deep-layer intratelencephalic': '71.3', 'Deep-layer near-projecting': '63.0', 'Eccentric medium spiny neuron': '53.8', 'Hippocampal ca1-3': '50.4', 'Hippocampal ca4': '62.1', 'Hippocampal dentate gyrus': '55.1', 'Lamp5-lhx6 and chandelier': '73.9', 'Lower rhombic lip': '65.1', 'Mammillary body': '74.2', 'Medium spiny neuron': '44.0', 'Mge interneuron': '67.8', 'Midbrain-derived inhibitory': '58.9', 'Miscellaneous': '69.0', 'Splatter': '67.3', 'Thalamic excitatory': '60.2', 'Upper rhombic lip': '98.7', 'Upper-layer intratelencephalic': '69.1', 'Astrocyte': '153.9', 'Bergmann glia': '71.1', 'Central nervous system macrophage': '86.5', 'Choroid plexus epithelial cell': '101.0', 'Committed oligodendrocyte precursor': '55.7', 'Ependymal cell': '80.1', 'Oligodendrocyte': '101.9', 'Oligodendrocyte precursor cell': '39.5', 'Endothelial cell': '278.0', 'Pericyte': '191.2', 'Vascular associated smooth muscle cell': '161.9', 'Fibroblast': '222.5', 'Leukocyte': '96.9', 'Basophil': '508.9', 'Eosinophil': '424.2', 'Neutrophil': '652.8', 'Classical monocyte': '47.8', 'Non-classical monocyte': '29.9', 'Intermediate monocyte': '356.0', 'T-reg': '142.5', 'GdT-cell': '195.4', 'MAIT T-cell': '215.6', 'Memory CD4 T-cell': '170.7', 'Naive CD4 T-cell': '16.2', 'Memory CD8 T-cell': '174.7', 'Naive CD8 T-cell': '21.4', 'Memory B-cell': '157.2', 'Naive B-cell': '25.8', 'Plasmacytoid DC': '115.9', 'Myeloid DC': '331.4', 'NK-cell': '36.1', 'Total PBMC': '257.2', 'Vd2 gdTCR': '223.7', 'Memory CD4 T-cell TFH': '40.8', 'Memory CD4 T-cell Th2': '31.0', 'Memory CD4 T-cell Th17': '32.4', 'Memory CD4 T-cell Th1\\/Th17': '28.7', 'Non-Vd2 gdTCR': '252.7', 'Memory CD4 T-cell Th1': '34.9', 'Terminal effector memory CD4 T-cell': '193.7', 'Central memory CD8 T-cell': '165.7', 'Effector memory CD8 T-cell': '183.8', 'Terminal effector memory CD8 T-cell': '202.0', 'Switched memory B-cell': '176.4', 'Plasmablast': '232.0', 'Non-switched memory B-cell': '141.3', 'Exhausted memory B-cell': '166.5', 'Progenitor cell': '129.8', 'Naive CD4 T-cell activated': '27.6', 'Naive CD8 T-cell activated': '47.1', 'Memory T-reg': '49.4', 'Naive T-reg': '25.3'}
1Q02, 2JY7, 2JY8, 2K0B, 2KNV, 4MJS, 4UF8, 4UF9, 5YP7, 5YP8, 5YPA, 5YPB, 5YPC, 5YPE, 5YPF, 5YPG, 5YPH, 6JM4, 6KHZ, 6MJ7, 6TGY, 6TH3, 7R1O
{'Adipose Tissue': 103.79857142857142, 'Adrenal Gland': 137.62174418604653, 'Bladder': 125.40238095238094, 'Blood': 40.866539289558666, 'Blood Vessel': 134.04116104868913, 'Brain': 37.39114193792581, 'Breast': 94.64023965141612, 'Cervix Uteri': 103.8763157894737, 'Colon': 71.5495892169448, 'Esophagus': 73.89315570934257, 'Fallopian Tube': 90.00555555555555, 'Heart': 45.45540301974448, 'Kidney': 49.14531460674157, 'Liver': 52.86030973451327, 'Lung': 102.5726124567474, 'Muscle': 180.5583312577833, 'Nerve': 93.75819063004846, 'Ovary': 96.6587777777778, 'Pancreas': 37.02713414634146, 'Pituitary': 64.30236749116608, 'Prostate': 73.32085714285715, 'Salivary Gland': 94.23123456790124, 'Skin': 81.7317965726921, 'Small Intestine': 61.07262032085561, 'Spleen': 55.89605809128631, 'Stomach': 72.66618384401114, 'Testis': 35.49343490304709, 'Thyroid': 129.193078101072, 'Uterus': 100.98084507042256, 'Vagina': 81.40307692307692}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
67.094841
0.643591
1,803
O60260
Q14190
17360614, E3NethUbiquitome
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
SIM2
MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEAPAAAVRRFGEDTAPPSFPSCGHYREEPALGPAKAARQAARDGARLALARAAPECCAPPTPEAPGAPAQLPFVLLNYHRVLARRGPLGGAAPAASGLACAPGGPEAATGALRLRHPSPAATSPPGAPLPHYLGASVIITNGR
Homo sapiens
Nucleus
Group enriched (esophagus, kidney)
{'Ciliated cells': '0.1', 'Basal respiratory cells': '0.0', 'Club cells': '0.5', 'Ionocytes': '0.0', 'Mucus glandular cells': '1.1', 'Serous glandular cells': '4.5', 'Gastric mucus-secreting cells': '14.1', 'Proximal enterocytes': '0.1', 'Paneth cells': '0.0', 'Distal enterocytes': '0.3', 'Intestinal goblet cells': '0.0', 'Exocrine glandular cells': '-0.344', 'Basal prostatic cells': '0.1', 'Prostatic glandular cells': '12.0', 'Breast glandular cells': '0.272', 'Breast myoepithelial cells': '0.030', 'Glandular and luminal cells': '0.1', 'Secretory cells': '0.0', 'Basal keratinocytes': '17.7', 'Suprabasal keratinocytes': '10.3', 'Basal squamous epithelial cells': '85.3', 'Squamous epithelial cells': '59.8', 'Alveolar cells type 1': '0.128', 'Alveolar cells type 2': '0.084', 'Salivary duct cells': '0.3', 'Ductal cells': '0.373', 'Hepatocytes': '0.120', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '-0.118', 'Distal tubular cells': '6.1', 'Collecting duct cells': '9.7', 'Mesothelial cells': '0.368', 'Sertoli cells': '-0.309', 'Granulosa cells': '0.0', 'Enteroendocrine cells': '0.0', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '-0.322', 'Excitatory neurons': '0.3', 'Inhibitory neurons': '0.4', 'Cone photoreceptor cells': '0.0', 'Rod photoreceptor cells': '0.4', 'Bipolar cells': '0.2', 'Horizontal cells': '1.3', 'Astrocytes': '0.0', 'Oligodendrocyte precursor cells': '6.6', 'Oligodendrocytes': '1.1', 'Microglial cells': '0.0', 'Muller glia cells': '0.0', 'Schwann cells': '0.243', 'Spermatogonia': '-0.003', 'Spermatocytes': '0.080', 'Early spermatids': '0.325', 'Late spermatids': '0.492', 'Oocytes': '0.0', 'Cytotrophoblasts': '0.0', 'Syncytiotrophoblasts': '0.0', 'Extravillous trophoblasts': '0.0', 'Endothelial cells': '0.6', 'Lymphatic endothelial cells': '0.0', 'Cardiomyocytes': '0.378', 'Skeletal myocytes': '0.006', 'Smooth muscle cells': '0.7', 'Adipocytes': '0.1', 'Melanocytes': '-0.131', 'Fibroblasts': '0.5', 'Peritubular cells': '-0.205', 'Endometrial stromal cells': '0.2', 'Ovarian stromal cells': '0.0', 'Undifferentiated cells': '0.5', 'T-cells': '0.3', 'B-cells': '0.0', 'Plasma cells': '0.8', 'Nk-cells': '0.0', 'Granulocytes': '3.2', 'Monocytes': '0.2', 'Macrophages': '0.5', 'Hofbauer cells': '0.0', 'Kupffer cells': '0.0', 'Dendritic cells': '0.0', 'Langerhans cells': '0.015', 'Erythroid cells': '-0.023', 'Adipocytes (Subcutaneous)': '0.101', 'Adipocytes (Visceral)': '-0.093', 'Breast glandular cells (progenitors)': '0.194', 'Adipocytes (Breast)': '0.028', 'Colon enterocytes': '-0.184', 'Colon enteroendocrine cells': '0.317', 'Enteric glia cells': '0.378', 'Mitotic cells (Colon)': '-0.318', 'Mitotic cells (Heart)': '0.383', 'Podocytes': '-0.213', 'Ascending Loop of Henle cells': '0.668', 'Intercalated cells': '-0.278', 'Cholangiocyte': '-0.022', 'NK-cells (Liver)': '0.094', 'Respiratory ciliated cells': '0.054', 'Mitotic cells (Lung)': '-0.015', 'NK-cells (Lung)': '-0.075', 'B-cells (Lung)': '-0.150', 'Alpha cells': '0.325', 'Beta cells': '0.177', 'Prostate glandular cells': '0.506', 'Prostate basal glandular cells': '0.196', 'Urothelial cells': '-0.040', 'Keratinocyte (other)': '-0.216', 'Keratinocyte (granular)': '-0.185', 'Hair cortex cells': '0.149', 'Inner root sheath cells': '0.065', 'Outer root sheath cells': '0.209', 'Sebaceous gland cells': '0.274', 'Eccrine sweat gland cells': '0.227', 'Adipocytes (Skin)': '0.305', 'Mitotic cells (Skin)': '-0.030', 'Parietal cells': '0.513', 'Chief cells': '0.620', 'Gastric mucous cells': '0.613', 'Gastric enteroendocrine cells': '0.638', 'Mitotic cells (Stomach)': '0.312', 'Parafollicular cells': '0.010', 'Thyroid glandular cells': '0.176', 'Mitotic cells (Thyroid)': '-0.076', 'Adrenal cortex cells': '0.216', 'Adrenal medulla cells': '0.112', 'Mitotic cells (Adrenal gland)': '0.159', 'Minor salivary glandular cells': '0.217', 'Minor salivary gland ductal cells': '0.185', 'Minor salivary gland basal cells': '0.007', 'Mitotic cells (Minor salivary gland)': '-0.106', 'Adipocytes (Minor salivary gland)': '-0.032', 'Somatotropes': '0.508', 'Lactotropes': '0.319', 'Gonadotropes': '0.251', 'Corticotropes': '-0.144', 'Thyrotropes': '-0.031', 'Undifferentiated cells (Pituitary gland)': '-0.198', 'Mitotic cells (Spleen)': '-0.336', 'Platelets': '-0.079', 'Erythrocytes': '-0.092', 'Hematopoietic stem cells': '-0.208', 'B-cells (Spleen)': '0.193', 'NK-cells (Spleen)': '0.221', 'Amygdala excitatory': '1.0', 'Cerebellar inhibitory': '2.0', 'Cge interneuron': '0.9', 'Deep-layer corticothalamic and 6b': '0.5', 'Deep-layer intratelencephalic': '0.7', 'Deep-layer near-projecting': '1.3', 'Eccentric medium spiny neuron': '0.9', 'Hippocampal ca1-3': '0.8', 'Hippocampal ca4': '1.0', 'Hippocampal dentate gyrus': '0.9', 'Lamp5-lhx6 and chandelier': '1.4', 'Lower rhombic lip': '1.1', 'Mammillary body': '2.2', 'Medium spiny neuron': '1.0', 'Mge interneuron': '0.9', 'Midbrain-derived inhibitory': '0.3', 'Miscellaneous': '0.6', 'Splatter': '1.8', 'Thalamic excitatory': '1.0', 'Upper rhombic lip': '2.1', 'Upper-layer intratelencephalic': '1.0', 'Astrocyte': '1.6', 'Bergmann glia': '2.2', 'Central nervous system macrophage': '0.3', 'Choroid plexus epithelial cell': '0.2', 'Committed oligodendrocyte precursor': '2.8', 'Ependymal cell': '3.2', 'Oligodendrocyte': '1.9', 'Oligodendrocyte precursor cell': '5.0', 'Endothelial cell': '0.3', 'Pericyte': '0.3', 'Vascular associated smooth muscle cell': '1.8', 'Fibroblast': '0.1', 'Leukocyte': '0.3', 'Basophil': '0.0', 'Eosinophil': '0.0', 'Neutrophil': '0.0', 'Classical monocyte': '0.1', 'Non-classical monocyte': '0.3', 'Intermediate monocyte': '0.0', 'T-reg': '0.0', 'GdT-cell': '0.0', 'MAIT T-cell': '0.0', 'Memory CD4 T-cell': '0.0', 'Naive CD4 T-cell': '0.7', 'Memory CD8 T-cell': '0.0', 'Naive CD8 T-cell': '0.7', 'Memory B-cell': '0.0', 'Naive B-cell': '0.4', 'Plasmacytoid DC': '0.0', 'Myeloid DC': '0.0', 'NK-cell': '0.9', 'Total PBMC': '0.0', 'Vd2 gdTCR': '0.0', 'Memory CD4 T-cell Th1\\/Th17': '0.7', 'Memory CD4 T-cell Th17': '0.6', 'Memory CD4 T-cell Th2': '0.7', 'Non-Vd2 gdTCR': '0.0', 'Memory CD4 T-cell Th1': '0.5', 'Memory CD4 T-cell TFH': '0.5', 'Terminal effector memory CD4 T-cell': '0.0', 'Central memory CD8 T-cell': '0.0', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '0.0', 'Non-switched memory B-cell': '0.0', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.0', 'Exhausted memory B-cell': '0.0', 'Progenitor cell': '0.0', 'Memory T-reg': '0.5', 'Naive CD4 T-cell activated': '0.1', 'Naive CD8 T-cell activated': '0.1', 'Naive T-reg': '0.8'}
null
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
61.967706
0.624768
1,090
O60260
Q14318
33082525, 23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
FKBP8
MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQPPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKGQVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN
Homo sapiens
Mitochondrion, Mitochondrion membrane, Mitochondrion membrane, Mitochondrion membrane
Low tissue specificity
{'Ciliated cells': '99.4', 'Basal respiratory cells': '113.0', 'Club cells': '105.4', 'Ionocytes': '75.5', 'Mucus glandular cells': '69.4', 'Serous glandular cells': '174.5', 'Gastric mucus-secreting cells': '74.9', 'Proximal enterocytes': '329.9', 'Paneth cells': '205.8', 'Distal enterocytes': '263.9', 'Intestinal goblet cells': '130.4', 'Exocrine glandular cells': '-0.358', 'Basal prostatic cells': '85.9', 'Prostatic glandular cells': '111.0', 'Breast glandular cells': '0.534', 'Breast myoepithelial cells': '0.468', 'Glandular and luminal cells': '70.1', 'Secretory cells': '145.8', 'Basal keratinocytes': '105.0', 'Suprabasal keratinocytes': '211.5', 'Basal squamous epithelial cells': '76.9', 'Squamous epithelial cells': '99.5', 'Alveolar cells type 1': '0.209', 'Alveolar cells type 2': '-0.566', 'Salivary duct cells': '65.5', 'Ductal cells': '0.342', 'Hepatocytes': '0.151', 'Cholangiocytes': '108.7', 'Proximal tubular cells': '0.100', 'Distal tubular cells': '166.0', 'Collecting duct cells': '99.2', 'Mesothelial cells': '0.430', 'Sertoli cells': '-0.342', 'Granulosa cells': '96.9', 'Enteroendocrine cells': '168.2', 'Pancreatic endocrine cells': '169.8', 'Leydig cells': '-0.452', 'Excitatory neurons': '30.9', 'Inhibitory neurons': '31.8', 'Cone photoreceptor cells': '61.2', 'Rod photoreceptor cells': '48.0', 'Bipolar cells': '57.7', 'Horizontal cells': '68.0', 'Astrocytes': '33.4', 'Oligodendrocyte precursor cells': '11.8', 'Oligodendrocytes': '30.6', 'Microglial cells': '8.1', 'Muller glia cells': '127.4', 'Schwann cells': '0.276', 'Spermatogonia': '-0.124', 'Spermatocytes': '-0.109', 'Early spermatids': '0.376', 'Late spermatids': '0.561', 'Oocytes': '65.4', 'Cytotrophoblasts': '248.2', 'Syncytiotrophoblasts': '325.4', 'Extravillous trophoblasts': '261.1', 'Endothelial cells': '89.6', 'Lymphatic endothelial cells': '123.4', 'Cardiomyocytes': '0.514', 'Skeletal myocytes': '0.073', 'Smooth muscle cells': '153.2', 'Adipocytes': '117.0', 'Melanocytes': '-0.037', 'Fibroblasts': '132.4', 'Peritubular cells': '-0.339', 'Endometrial stromal cells': '59.9', 'Ovarian stromal cells': '206.3', 'Undifferentiated cells': '131.1', 'T-cells': '134.4', 'B-cells': '100.4', 'Plasma cells': '138.1', 'Nk-cells': '140.6', 'Granulocytes': '119.6', 'Monocytes': '153.7', 'Macrophages': '126.2', 'Hofbauer cells': '257.6', 'Kupffer cells': '127.2', 'Dendritic cells': '56.4', 'Langerhans cells': '0.112', 'Erythroid cells': '0.079', 'Adipocytes (Subcutaneous)': '-0.121', 'Adipocytes (Visceral)': '-0.259', 'Breast glandular cells (progenitors)': '0.419', 'Adipocytes (Breast)': '-0.449', 'Colon enterocytes': '-0.366', 'Colon enteroendocrine cells': '0.172', 'Enteric glia cells': '0.580', 'Mitotic cells (Colon)': '-0.381', 'Mitotic cells (Heart)': '0.368', 'Podocytes': '-0.032', 'Ascending Loop of Henle cells': '0.473', 'Intercalated cells': '0.013', 'Cholangiocyte': '0.198', 'NK-cells (Liver)': '-0.079', 'Respiratory ciliated cells': '0.139', 'Mitotic cells (Lung)': '-0.181', 'NK-cells (Lung)': '0.360', 'B-cells (Lung)': '0.139', 'Alpha cells': '0.420', 'Beta cells': '0.223', 'Prostate glandular cells': '0.011', 'Prostate basal glandular cells': '-0.045', 'Urothelial cells': '-0.048', 'Keratinocyte (other)': '-0.126', 'Keratinocyte (granular)': '-0.162', 'Hair cortex cells': '0.210', 'Inner root sheath cells': '0.164', 'Outer root sheath cells': '0.303', 'Sebaceous gland cells': '-0.085', 'Eccrine sweat gland cells': '0.148', 'Adipocytes (Skin)': '0.182', 'Mitotic cells (Skin)': '-0.016', 'Parietal cells': '-0.754', 'Chief cells': '-0.539', 'Gastric mucous cells': '-0.565', 'Gastric enteroendocrine cells': '-0.438', 'Mitotic cells (Stomach)': '-0.191', 'Parafollicular cells': '0.064', 'Thyroid glandular cells': '0.207', 'Mitotic cells (Thyroid)': '-0.091', 'Adrenal cortex cells': '0.256', 'Adrenal medulla cells': '0.214', 'Mitotic cells (Adrenal gland)': '0.154', 'Minor salivary glandular cells': '0.108', 'Minor salivary gland ductal cells': '-0.068', 'Minor salivary gland basal cells': '0.329', 'Mitotic cells (Minor salivary gland)': '0.239', 'Adipocytes (Minor salivary gland)': '0.102', 'Somatotropes': '0.127', 'Lactotropes': '0.086', 'Gonadotropes': '0.021', 'Corticotropes': '-0.064', 'Thyrotropes': '0.118', 'Undifferentiated cells (Pituitary gland)': '0.155', 'Mitotic cells (Spleen)': '-0.216', 'Platelets': '-0.008', 'Erythrocytes': '0.369', 'Hematopoietic stem cells': '0.001', 'B-cells (Spleen)': '0.022', 'NK-cells (Spleen)': '0.212', 'Amygdala excitatory': '39.9', 'Cerebellar inhibitory': '56.7', 'Cge interneuron': '66.0', 'Deep-layer corticothalamic and 6b': '51.6', 'Deep-layer intratelencephalic': '53.6', 'Deep-layer near-projecting': '67.7', 'Eccentric medium spiny neuron': '56.6', 'Hippocampal ca1-3': '40.9', 'Hippocampal ca4': '53.8', 'Hippocampal dentate gyrus': '39.8', 'Lamp5-lhx6 and chandelier': '66.4', 'Lower rhombic lip': '73.5', 'Mammillary body': '43.7', 'Medium spiny neuron': '44.5', 'Mge interneuron': '59.3', 'Midbrain-derived inhibitory': '84.5', 'Miscellaneous': '55.1', 'Splatter': '68.4', 'Thalamic excitatory': '94.4', 'Upper rhombic lip': '74.2', 'Upper-layer intratelencephalic': '42.0', 'Astrocyte': '47.7', 'Bergmann glia': '52.8', 'Central nervous system macrophage': '28.5', 'Choroid plexus epithelial cell': '44.7', 'Committed oligodendrocyte precursor': '48.0', 'Ependymal cell': '84.3', 'Oligodendrocyte': '78.1', 'Oligodendrocyte precursor cell': '34.9', 'Endothelial cell': '43.7', 'Pericyte': '72.5', 'Vascular associated smooth muscle cell': '51.4', 'Fibroblast': '35.1', 'Leukocyte': '68.4', 'Basophil': '50.1', 'Eosinophil': '93.7', 'Neutrophil': '384.9', 'Classical monocyte': '91.0', 'Non-classical monocyte': '74.2', 'Intermediate monocyte': '63.5', 'T-reg': '45.0', 'GdT-cell': '14.3', 'MAIT T-cell': '43.5', 'Memory CD4 T-cell': '14.6', 'Naive CD4 T-cell': '60.3', 'Memory CD8 T-cell': '16.3', 'Naive CD8 T-cell': '99.2', 'Memory B-cell': '10.2', 'Naive B-cell': '34.1', 'Plasmacytoid DC': '32.9', 'Myeloid DC': '49.2', 'NK-cell': '86.3', 'Total PBMC': '68.3', 'Vd2 gdTCR': '48.6', 'Memory CD4 T-cell Th1\\/Th17': '68.5', 'Memory CD4 T-cell Th17': '109.8', 'Memory CD4 T-cell Th2': '114.0', 'Non-Vd2 gdTCR': '46.3', 'Memory CD4 T-cell Th1': '128.3', 'Memory CD4 T-cell TFH': '199.6', 'Terminal effector memory CD4 T-cell': '43.1', 'Central memory CD8 T-cell': '46.4', 'Effector memory CD8 T-cell': '60.2', 'Terminal effector memory CD8 T-cell': '46.7', 'Non-switched memory B-cell': '57.2', 'Plasmablast': '84.2', 'Switched memory B-cell': '69.0', 'Exhausted memory B-cell': '62.3', 'Progenitor cell': '75.2', 'Memory T-reg': '206.4', 'Naive CD4 T-cell activated': '31.8', 'Naive CD8 T-cell activated': '40.6', 'Naive T-reg': '115.2'}
2AWG, 2D9F, 2F2D, 2MF9, 3EY6, 5MGX
{'Adipose Tissue': 220.64338870431897, 'Adrenal Gland': 141.5460465116279, 'Bladder': 275.93809523809523, 'Blood': 1583.9889128094726, 'Blood Vessel': 361.0332584269663, 'Brain': 351.793773656321, 'Breast': 230.39562091503268, 'Cervix Uteri': 326.4578947368421, 'Colon': 267.2591784338896, 'Esophagus': 269.9551557093426, 'Fallopian Tube': 282.9, 'Heart': 114.23056910569106, 'Kidney': 136.6873033707865, 'Liver': 101.18526548672564, 'Lung': 245.8262975778547, 'Muscle': 100.08901618929016, 'Nerve': 352.6369951534733, 'Ovary': 351.37944444444446, 'Pancreas': 67.13289634146342, 'Pituitary': 365.8879858657244, 'Prostate': 304.2191836734694, 'Salivary Gland': 174.25493827160494, 'Skin': 205.63090657822, 'Small Intestine': 169.99588235294118, 'Spleen': 211.16958506224069, 'Stomach': 167.78050139275766, 'Testis': 557.2705817174515, 'Thyroid': 290.8803215926493, 'Uterus': 311.0091549295775, 'Vagina': 286.3814102564103}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
80.495194
0.493592
1,928
O60260
Q14BN4
33082525
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
SLMAP
MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQVRLEHLQEKTLKECSSLEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNNKPWPWMPMLAALVAVTAIVLYVPGLARASP
Homo sapiens
Cell membrane, sarcolemma, Cytoplasm, myofibril, sarcomere, M line, Cytoplasm, myofibril, sarcomere, Z line, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Endoplasmic reticulum membrane, Mitochondrion membrane, Endoplasmic reticulum membrane, Mitochondrion membrane, Endoplasmic reticulum membrane, Mitochondrion membrane, Endoplasmic reticulum membrane, Mitochondrion membrane, Endoplasmic reticulum membrane
Low tissue specificity
{'Ciliated cells': '47.5', 'Basal respiratory cells': '51.4', 'Club cells': '37.4', 'Ionocytes': '43.4', 'Mucus glandular cells': '45.6', 'Serous glandular cells': '33.1', 'Gastric mucus-secreting cells': '47.2', 'Proximal enterocytes': '33.6', 'Paneth cells': '20.2', 'Distal enterocytes': '43.0', 'Intestinal goblet cells': '28.2', 'Exocrine glandular cells': '-0.510', 'Basal prostatic cells': '37.3', 'Prostatic glandular cells': '28.3', 'Breast glandular cells': '0.373', 'Breast myoepithelial cells': '0.682', 'Glandular and luminal cells': '54.3', 'Secretory cells': '23.0', 'Basal keratinocytes': '78.4', 'Suprabasal keratinocytes': '60.0', 'Basal squamous epithelial cells': '55.4', 'Squamous epithelial cells': '53.1', 'Alveolar cells type 1': '0.286', 'Alveolar cells type 2': '-0.218', 'Salivary duct cells': '52.6', 'Ductal cells': '0.646', 'Hepatocytes': '0.402', 'Cholangiocytes': '47.7', 'Proximal tubular cells': '0.187', 'Distal tubular cells': '3.1', 'Collecting duct cells': '31.1', 'Mesothelial cells': '0.316', 'Sertoli cells': '0.410', 'Granulosa cells': '30.4', 'Enteroendocrine cells': '28.8', 'Pancreatic endocrine cells': '10.2', 'Leydig cells': '0.342', 'Excitatory neurons': '109.5', 'Inhibitory neurons': '116.4', 'Cone photoreceptor cells': '25.5', 'Rod photoreceptor cells': '32.2', 'Bipolar cells': '23.4', 'Horizontal cells': '37.1', 'Astrocytes': '85.5', 'Oligodendrocyte precursor cells': '94.8', 'Oligodendrocytes': '90.9', 'Microglial cells': '73.4', 'Muller glia cells': '74.0', 'Schwann cells': '0.066', 'Spermatogonia': '0.598', 'Spermatocytes': '0.676', 'Early spermatids': '0.115', 'Late spermatids': '-0.382', 'Oocytes': '6.6', 'Cytotrophoblasts': '19.8', 'Syncytiotrophoblasts': '16.6', 'Extravillous trophoblasts': '12.8', 'Endothelial cells': '23.7', 'Lymphatic endothelial cells': '14.9', 'Cardiomyocytes': '0.736', 'Skeletal myocytes': '0.239', 'Smooth muscle cells': '99.9', 'Adipocytes': '17.3', 'Melanocytes': '0.143', 'Fibroblasts': '27.3', 'Peritubular cells': '0.304', 'Endometrial stromal cells': '22.9', 'Ovarian stromal cells': '37.5', 'Undifferentiated cells': '26.2', 'T-cells': '26.8', 'B-cells': '23.3', 'Plasma cells': '32.0', 'Nk-cells': '35.6', 'Granulocytes': '16.0', 'Monocytes': '35.3', 'Macrophages': '23.7', 'Hofbauer cells': '15.4', 'Kupffer cells': '19.4', 'Dendritic cells': '36.8', 'Langerhans cells': '0.212', 'Erythroid cells': '-0.051', 'Adipocytes (Subcutaneous)': '-0.463', 'Adipocytes (Visceral)': '-0.372', 'Breast glandular cells (progenitors)': '0.317', 'Adipocytes (Breast)': '-0.589', 'Colon enterocytes': '-0.205', 'Colon enteroendocrine cells': '0.115', 'Enteric glia cells': '-0.106', 'Mitotic cells (Colon)': '-0.165', 'Mitotic cells (Heart)': '0.456', 'Podocytes': '0.026', 'Ascending Loop of Henle cells': '0.416', 'Intercalated cells': '0.010', 'Cholangiocyte': '0.294', 'NK-cells (Liver)': '-0.198', 'Respiratory ciliated cells': '0.165', 'Mitotic cells (Lung)': '-0.111', 'NK-cells (Lung)': '0.267', 'B-cells (Lung)': '0.082', 'Alpha cells': '0.395', 'Beta cells': '0.242', 'Prostate glandular cells': '-0.343', 'Prostate basal glandular cells': '-0.186', 'Urothelial cells': '-0.218', 'Keratinocyte (other)': '0.315', 'Keratinocyte (granular)': '-0.160', 'Hair cortex cells': '-0.066', 'Inner root sheath cells': '0.008', 'Outer root sheath cells': '0.195', 'Sebaceous gland cells': '-0.030', 'Eccrine sweat gland cells': '0.093', 'Adipocytes (Skin)': '-0.205', 'Mitotic cells (Skin)': '0.367', 'Parietal cells': '-0.687', 'Chief cells': '-0.575', 'Gastric mucous cells': '-0.568', 'Gastric enteroendocrine cells': '-0.476', 'Mitotic cells (Stomach)': '-0.177', 'Parafollicular cells': '0.078', 'Thyroid glandular cells': '0.418', 'Mitotic cells (Thyroid)': '-0.005', 'Adrenal cortex cells': '0.739', 'Adrenal medulla cells': '-0.017', 'Mitotic cells (Adrenal gland)': '0.383', 'Minor salivary glandular cells': '0.462', 'Minor salivary gland ductal cells': '0.139', 'Minor salivary gland basal cells': '0.473', 'Mitotic cells (Minor salivary gland)': '0.448', 'Adipocytes (Minor salivary gland)': '0.222', 'Somatotropes': '-0.068', 'Lactotropes': '-0.031', 'Gonadotropes': '0.067', 'Corticotropes': '-0.098', 'Thyrotropes': '0.223', 'Undifferentiated cells (Pituitary gland)': '0.253', 'Mitotic cells (Spleen)': '-0.095', 'Platelets': '-0.026', 'Erythrocytes': '-0.062', 'Hematopoietic stem cells': '-0.107', 'B-cells (Spleen)': '0.202', 'NK-cells (Spleen)': '0.241', 'Amygdala excitatory': '177.2', 'Cerebellar inhibitory': '139.1', 'Cge interneuron': '164.0', 'Deep-layer corticothalamic and 6b': '146.2', 'Deep-layer intratelencephalic': '157.8', 'Deep-layer near-projecting': '141.3', 'Eccentric medium spiny neuron': '176.9', 'Hippocampal ca1-3': '173.8', 'Hippocampal ca4': '163.4', 'Hippocampal dentate gyrus': '188.2', 'Lamp5-lhx6 and chandelier': '164.9', 'Lower rhombic lip': '182.6', 'Mammillary body': '180.9', 'Medium spiny neuron': '356.2', 'Mge interneuron': '168.2', 'Midbrain-derived inhibitory': '196.0', 'Miscellaneous': '152.5', 'Splatter': '149.1', 'Thalamic excitatory': '171.8', 'Upper rhombic lip': '191.4', 'Upper-layer intratelencephalic': '159.2', 'Astrocyte': '202.7', 'Bergmann glia': '175.1', 'Central nervous system macrophage': '182.9', 'Choroid plexus epithelial cell': '220.2', 'Committed oligodendrocyte precursor': '136.6', 'Ependymal cell': '189.3', 'Oligodendrocyte': '162.7', 'Oligodendrocyte precursor cell': '162.8', 'Endothelial cell': '209.9', 'Pericyte': '150.1', 'Vascular associated smooth muscle cell': '465.0', 'Fibroblast': '226.8', 'Leukocyte': '196.0', 'Basophil': '31.1', 'Eosinophil': '11.4', 'Neutrophil': '56.9', 'Classical monocyte': '15.5', 'Non-classical monocyte': '14.1', 'Intermediate monocyte': '16.9', 'T-reg': '18.5', 'GdT-cell': '3.7', 'MAIT T-cell': '20.0', 'Memory CD4 T-cell': '2.9', 'Naive CD4 T-cell': '21.1', 'Memory CD8 T-cell': '3.3', 'Naive CD8 T-cell': '18.4', 'Memory B-cell': '3.8', 'Naive B-cell': '19.3', 'Plasmacytoid DC': '12.2', 'Myeloid DC': '11.8', 'NK-cell': '19.8', 'Total PBMC': '18.7', 'Vd2 gdTCR': '23.5', 'Memory CD4 T-cell TFH': '18.0', 'Memory CD4 T-cell Th2': '20.3', 'Memory CD4 T-cell Th17': '18.1', 'Memory CD4 T-cell Th1\\/Th17': '23.0', 'Non-Vd2 gdTCR': '22.3', 'Memory CD4 T-cell Th1': '19.8', 'Terminal effector memory CD4 T-cell': '24.6', 'Central memory CD8 T-cell': '19.4', 'Effector memory CD8 T-cell': '19.3', 'Terminal effector memory CD8 T-cell': '20.1', 'Switched memory B-cell': '18.8', 'Plasmablast': '20.6', 'Non-switched memory B-cell': '15.6', 'Exhausted memory B-cell': '16.5', 'Progenitor cell': '15.9', 'Memory T-reg': '18.6', 'Naive CD4 T-cell activated': '20.3', 'Naive CD8 T-cell activated': '21.4', 'Naive T-reg': '22.8'}
6AKM, 6AR0, 6AR2
{'Adipose Tissue': 12.069024086378738, 'Adrenal Gland': 10.870790697674416, 'Bladder': 50.58095238095238, 'Blood': 4.606960592034445, 'Blood Vessel': 55.88423445692884, 'Brain': 5.631539591218774, 'Breast': 13.200409586056644, 'Cervix Uteri': 17.099736842105262, 'Colon': 50.16770089858794, 'Esophagus': 40.003415224913496, 'Fallopian Tube': 32.61888888888889, 'Heart': 18.24138675958188, 'Kidney': 5.052505617977528, 'Liver': 2.7543106194690266, 'Lung': 10.842882352941176, 'Muscle': 12.790849315068492, 'Nerve': 13.74041518578352, 'Ovary': 16.719733333333334, 'Pancreas': 2.908734451219512, 'Pituitary': 7.464325088339223, 'Prostate': 23.91990612244898, 'Salivary Gland': 10.29104938271605, 'Skin': 11.913178551686014, 'Small Intestine': 20.22644919786096, 'Spleen': 5.684145228215767, 'Stomach': 25.392727019498604, 'Testis': 13.79493351800554, 'Thyroid': 14.051762633996937, 'Uterus': 51.93260563380282, 'Vagina': 19.256224358974357}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
76.903672
0.585592
758
O60260
Q15149
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PLEC
MVAGMLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRETFAWCHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLGSPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
Homo sapiens
Cytoplasm, cytoskeleton, Cell junction, hemidesmosome, Cell projection, podosome
Tissue enhanced (skeletal)
{'Ciliated cells': '57.1', 'Basal respiratory cells': '57.4', 'Club cells': '57.7', 'Ionocytes': '55.2', 'Mucus glandular cells': '45.0', 'Serous glandular cells': '50.5', 'Gastric mucus-secreting cells': '160.9', 'Proximal enterocytes': '111.8', 'Paneth cells': '72.2', 'Distal enterocytes': '145.6', 'Intestinal goblet cells': '64.9', 'Exocrine glandular cells': '-0.644', 'Basal prostatic cells': '60.6', 'Prostatic glandular cells': '30.5', 'Breast glandular cells': '0.433', 'Breast myoepithelial cells': '0.478', 'Glandular and luminal cells': '45.8', 'Secretory cells': '50.8', 'Basal keratinocytes': '113.0', 'Suprabasal keratinocytes': '95.7', 'Basal squamous epithelial cells': '57.2', 'Squamous epithelial cells': '71.3', 'Alveolar cells type 1': '-0.038', 'Alveolar cells type 2': '-0.189', 'Salivary duct cells': '55.0', 'Ductal cells': '0.653', 'Hepatocytes': '0.385', 'Cholangiocytes': '26.7', 'Proximal tubular cells': '0.048', 'Distal tubular cells': '0.0', 'Collecting duct cells': '46.7', 'Mesothelial cells': '0.268', 'Sertoli cells': '0.510', 'Granulosa cells': '13.7', 'Enteroendocrine cells': '35.0', 'Pancreatic endocrine cells': '10.2', 'Leydig cells': '0.509', 'Excitatory neurons': '45.7', 'Inhibitory neurons': '35.0', 'Cone photoreceptor cells': '1.7', 'Rod photoreceptor cells': '9.4', 'Bipolar cells': '12.9', 'Horizontal cells': '46.0', 'Astrocytes': '74.0', 'Oligodendrocyte precursor cells': '13.7', 'Oligodendrocytes': '3.1', 'Microglial cells': '25.9', 'Muller glia cells': '12.8', 'Schwann cells': '0.129', 'Spermatogonia': '0.306', 'Spermatocytes': '-0.032', 'Early spermatids': '-0.647', 'Late spermatids': '-0.607', 'Oocytes': '2.2', 'Cytotrophoblasts': '32.9', 'Syncytiotrophoblasts': '62.2', 'Extravillous trophoblasts': '34.9', 'Endothelial cells': '79.5', 'Lymphatic endothelial cells': '124.2', 'Cardiomyocytes': '0.711', 'Skeletal myocytes': '0.188', 'Smooth muscle cells': '63.9', 'Adipocytes': '79.9', 'Melanocytes': '-0.010', 'Fibroblasts': '50.2', 'Peritubular cells': '0.543', 'Endometrial stromal cells': '49.5', 'Ovarian stromal cells': '32.1', 'Undifferentiated cells': '26.0', 'T-cells': '39.9', 'B-cells': '30.3', 'Plasma cells': '32.7', 'Nk-cells': '16.3', 'Granulocytes': '21.0', 'Monocytes': '111.7', 'Macrophages': '84.3', 'Hofbauer cells': '45.7', 'Kupffer cells': '60.9', 'Dendritic cells': '28.5', 'Langerhans cells': '0.054', 'Erythroid cells': '-0.163', 'Adipocytes (Subcutaneous)': '-0.418', 'Adipocytes (Visceral)': '-0.062', 'Breast glandular cells (progenitors)': '0.303', 'Adipocytes (Breast)': '-0.337', 'Colon enterocytes': '-0.188', 'Colon enteroendocrine cells': '0.188', 'Enteric glia cells': '0.285', 'Mitotic cells (Colon)': '-0.125', 'Mitotic cells (Heart)': '0.463', 'Podocytes': '-0.198', 'Ascending Loop of Henle cells': '0.304', 'Intercalated cells': '-0.260', 'Cholangiocyte': '0.306', 'NK-cells (Liver)': '-0.322', 'Respiratory ciliated cells': '0.118', 'Mitotic cells (Lung)': '0.026', 'NK-cells (Lung)': '0.062', 'B-cells (Lung)': '-0.015', 'Alpha cells': '0.413', 'Beta cells': '0.278', 'Prostate glandular cells': '-0.312', 'Prostate basal glandular cells': '0.069', 'Urothelial cells': '0.169', 'Keratinocyte (other)': '0.013', 'Keratinocyte (granular)': '0.321', 'Hair cortex cells': '-0.038', 'Inner root sheath cells': '-0.109', 'Outer root sheath cells': '-0.154', 'Sebaceous gland cells': '-0.039', 'Eccrine sweat gland cells': '-0.134', 'Adipocytes (Skin)': '-0.009', 'Mitotic cells (Skin)': '-0.188', 'Parietal cells': '-0.647', 'Chief cells': '-0.594', 'Gastric mucous cells': '-0.295', 'Gastric enteroendocrine cells': '-0.431', 'Mitotic cells (Stomach)': '0.021', 'Parafollicular cells': '0.000', 'Thyroid glandular cells': '-0.004', 'Mitotic cells (Thyroid)': '0.216', 'Adrenal cortex cells': '0.230', 'Adrenal medulla cells': '0.032', 'Mitotic cells (Adrenal gland)': '0.263', 'Minor salivary glandular cells': '0.128', 'Minor salivary gland ductal cells': '0.055', 'Minor salivary gland basal cells': '0.371', 'Mitotic cells (Minor salivary gland)': '0.363', 'Adipocytes (Minor salivary gland)': '0.148', 'Somatotropes': '-0.097', 'Lactotropes': '-0.115', 'Gonadotropes': '0.158', 'Corticotropes': '-0.198', 'Thyrotropes': '0.033', 'Undifferentiated cells (Pituitary gland)': '0.253', 'Mitotic cells (Spleen)': '-0.259', 'Platelets': '-0.001', 'Erythrocytes': '-0.137', 'Hematopoietic stem cells': '-0.261', 'B-cells (Spleen)': '0.215', 'NK-cells (Spleen)': '0.250', 'Amygdala excitatory': '74.5', 'Cerebellar inhibitory': '39.8', 'Cge interneuron': '42.0', 'Deep-layer corticothalamic and 6b': '65.0', 'Deep-layer intratelencephalic': '74.3', 'Deep-layer near-projecting': '59.9', 'Eccentric medium spiny neuron': '62.7', 'Hippocampal ca1-3': '73.2', 'Hippocampal ca4': '56.3', 'Hippocampal dentate gyrus': '53.3', 'Lamp5-lhx6 and chandelier': '54.2', 'Lower rhombic lip': '65.5', 'Mammillary body': '63.1', 'Medium spiny neuron': '69.8', 'Mge interneuron': '63.2', 'Midbrain-derived inhibitory': '46.7', 'Miscellaneous': '80.4', 'Splatter': '56.1', 'Thalamic excitatory': '78.3', 'Upper rhombic lip': '34.2', 'Upper-layer intratelencephalic': '73.9', 'Astrocyte': '173.4', 'Bergmann glia': '53.5', 'Central nervous system macrophage': '63.4', 'Choroid plexus epithelial cell': '32.8', 'Committed oligodendrocyte precursor': '39.6', 'Ependymal cell': '100.1', 'Oligodendrocyte': '4.4', 'Oligodendrocyte precursor cell': '22.5', 'Endothelial cell': '87.6', 'Pericyte': '32.1', 'Vascular associated smooth muscle cell': '112.5', 'Fibroblast': '51.2', 'Leukocyte': '71.5', 'Basophil': '10.0', 'Eosinophil': '0.1', 'Neutrophil': '28.3', 'Classical monocyte': '67.6', 'Non-classical monocyte': '62.4', 'Intermediate monocyte': '63.1', 'T-reg': '33.3', 'GdT-cell': '0.6', 'MAIT T-cell': '30.0', 'Memory CD4 T-cell': '1.2', 'Naive CD4 T-cell': '46.0', 'Memory CD8 T-cell': '0.9', 'Naive CD8 T-cell': '46.9', 'Memory B-cell': '0.6', 'Naive B-cell': '30.4', 'Plasmacytoid DC': '21.8', 'Myeloid DC': '46.5', 'NK-cell': '28.6', 'Total PBMC': '34.1', 'Vd2 gdTCR': '19.1', 'Memory CD4 T-cell Th1\\/Th17': '40.8', 'Memory CD4 T-cell Th17': '112.8', 'Memory CD4 T-cell Th2': '97.8', 'Non-Vd2 gdTCR': '17.1', 'Memory CD4 T-cell Th1': '78.8', 'Memory CD4 T-cell TFH': '156.3', 'Terminal effector memory CD4 T-cell': '28.5', 'Central memory CD8 T-cell': '31.9', 'Effector memory CD8 T-cell': '28.1', 'Terminal effector memory CD8 T-cell': '17.9', 'Non-switched memory B-cell': '26.0', 'Plasmablast': '22.5', 'Switched memory B-cell': '28.1', 'Exhausted memory B-cell': '25.6', 'Progenitor cell': '8.5', 'Memory T-reg': '188.7', 'Naive CD4 T-cell activated': '85.1', 'Naive CD8 T-cell activated': '105.5', 'Naive T-reg': '60.0'}
1MB8, 2N03, 2ODU, 2ODV, 3F7P, 3PDY, 3PE0, 4GDO, 4Q58, 4Q59, 5J1F, 5J1G, 5J1H, 5J1I
{'Adipose Tissue': 66.30808970099667, 'Adrenal Gland': 40.80364728682171, 'Bladder': 103.08809523809524, 'Blood': 37.22095382131324, 'Blood Vessel': 139.50295880149812, 'Brain': 36.54284746404239, 'Breast': 67.87540305010893, 'Cervix Uteri': 117.46263157894737, 'Colon': 86.81400513478819, 'Esophagus': 95.70539792387542, 'Fallopian Tube': 101.62222222222222, 'Heart': 41.308743321718936, 'Kidney': 32.40449438202247, 'Liver': 21.20254424778761, 'Lung': 95.80716262975778, 'Muscle': 154.1615815691158, 'Nerve': 245.2804523424879, 'Ovary': 89.55905555555555, 'Pancreas': 17.684435975609755, 'Pituitary': 60.82113074204947, 'Prostate': 93.94138775510204, 'Salivary Gland': 62.79617283950617, 'Skin': 149.78446655610833, 'Small Intestine': 82.0312834224599, 'Spleen': 75.83029045643153, 'Stomach': 61.90779944289694, 'Testis': 33.989066481994456, 'Thyroid': 53.87029096477795, 'Uterus': 129.44922535211268, 'Vagina': 106.7849358974359}
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null
null
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
null
null
10
O60260
Q15303
15632191
UbiNet, UbiBrowser
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ERBB4
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
Homo sapiens
Cell membrane, Nucleus, Mitochondrion
Tissue enhanced (brain, fallopian tube)
{'Ciliated cells': '43.3', 'Basal respiratory cells': '1.0', 'Club cells': '5.5', 'Ionocytes': '2.2', 'Mucus glandular cells': '19.8', 'Serous glandular cells': '18.7', 'Gastric mucus-secreting cells': '0.0', 'Proximal enterocytes': '0.0', 'Paneth cells': '0.0', 'Distal enterocytes': '0.2', 'Intestinal goblet cells': '0.0', 'Exocrine glandular cells': '-0.196', 'Basal prostatic cells': '14.0', 'Prostatic glandular cells': '3.0', 'Breast glandular cells': '0.805', 'Breast myoepithelial cells': '0.591', 'Glandular and luminal cells': '20.8', 'Secretory cells': '35.1', 'Basal keratinocytes': '0.5', 'Suprabasal keratinocytes': '0.5', 'Basal squamous epithelial cells': '0.9', 'Squamous epithelial cells': '0.2', 'Alveolar cells type 1': '0.095', 'Alveolar cells type 2': '0.569', 'Salivary duct cells': '5.7', 'Ductal cells': '0.455', 'Hepatocytes': '0.138', 'Cholangiocytes': '1.9', 'Proximal tubular cells': '0.143', 'Distal tubular cells': '3.1', 'Collecting duct cells': '11.7', 'Mesothelial cells': '0.728', 'Sertoli cells': '0.810', 'Granulosa cells': '2.9', 'Enteroendocrine cells': '0.0', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.501', 'Excitatory neurons': '59.8', 'Inhibitory neurons': '5860.5', 'Cone photoreceptor cells': '0.0', 'Rod photoreceptor cells': '1.5', 'Bipolar cells': '11.3', 'Horizontal cells': '13.2', 'Astrocytes': '1916.0', 'Oligodendrocyte precursor cells': '2222.9', 'Oligodendrocytes': '977.4', 'Microglial cells': '92.1', 'Muller glia cells': '8.6', 'Schwann cells': '0.538', 'Spermatogonia': '0.401', 'Spermatocytes': '0.134', 'Early spermatids': '-0.387', 'Late spermatids': '-0.613', 'Oocytes': '10.3', 'Cytotrophoblasts': '0.1', 'Syncytiotrophoblasts': '0.0', 'Extravillous trophoblasts': '0.2', 'Endothelial cells': '0.8', 'Lymphatic endothelial cells': '0.5', 'Cardiomyocytes': '0.701', 'Skeletal myocytes': '0.401', 'Smooth muscle cells': '4.2', 'Adipocytes': '0.7', 'Melanocytes': '-0.054', 'Fibroblasts': '1.4', 'Peritubular cells': '0.433', 'Endometrial stromal cells': '0.8', 'Ovarian stromal cells': '0.1', 'Undifferentiated cells': '0.1', 'T-cells': '0.3', 'B-cells': '0.1', 'Plasma cells': '0.5', 'Nk-cells': '0.0', 'Granulocytes': '0.4', 'Monocytes': '0.0', 'Macrophages': '0.4', 'Hofbauer cells': '0.1', 'Kupffer cells': '0.0', 'Dendritic cells': '0.0', 'Langerhans cells': '-0.049', 'Erythroid cells': '0.066', 'Adipocytes (Subcutaneous)': '0.043', 'Adipocytes (Visceral)': '-0.064', 'Breast glandular cells (progenitors)': '0.433', 'Adipocytes (Breast)': '-0.572', 'Colon enterocytes': '-0.126', 'Colon enteroendocrine cells': '0.417', 'Enteric glia cells': '0.335', 'Mitotic cells (Colon)': '-0.206', 'Mitotic cells (Heart)': '0.323', 'Podocytes': '0.138', 'Ascending Loop of Henle cells': '0.522', 'Intercalated cells': '0.235', 'Cholangiocyte': '0.258', 'NK-cells (Liver)': '0.137', 'Respiratory ciliated cells': '0.426', 'Mitotic cells (Lung)': '0.031', 'NK-cells (Lung)': '-0.288', 'B-cells (Lung)': '-0.160', 'Alpha cells': '0.211', 'Beta cells': '0.161', 'Prostate glandular cells': '0.210', 'Prostate basal glandular cells': '0.403', 'Urothelial cells': '0.338', 'Keratinocyte (other)': '-0.128', 'Keratinocyte (granular)': '-0.176', 'Hair cortex cells': '0.170', 'Inner root sheath cells': '0.177', 'Outer root sheath cells': '0.254', 'Sebaceous gland cells': '0.064', 'Eccrine sweat gland cells': '0.666', 'Adipocytes (Skin)': '0.238', 'Mitotic cells (Skin)': '0.108', 'Parietal cells': '0.689', 'Chief cells': '0.690', 'Gastric mucous cells': '0.500', 'Gastric enteroendocrine cells': '0.535', 'Mitotic cells (Stomach)': '0.140', 'Parafollicular cells': '0.142', 'Thyroid glandular cells': '0.490', 'Mitotic cells (Thyroid)': '-0.079', 'Adrenal cortex cells': '0.122', 'Adrenal medulla cells': '0.572', 'Mitotic cells (Adrenal gland)': '0.087', 'Minor salivary glandular cells': '0.671', 'Minor salivary gland ductal cells': '0.386', 'Minor salivary gland basal cells': '-0.507', 'Mitotic cells (Minor salivary gland)': '-0.555', 'Adipocytes (Minor salivary gland)': '-0.338', 'Somatotropes': '-0.436', 'Lactotropes': '-0.411', 'Gonadotropes': '-0.077', 'Corticotropes': '0.121', 'Thyrotropes': '0.067', 'Undifferentiated cells (Pituitary gland)': '0.607', 'Mitotic cells (Spleen)': '-0.207', 'Platelets': '-0.165', 'Erythrocytes': '-0.071', 'Hematopoietic stem cells': '-0.203', 'B-cells (Spleen)': '0.117', 'NK-cells (Spleen)': '0.233', 'Amygdala excitatory': '147.9', 'Cerebellar inhibitory': '19.4', 'Cge interneuron': '8806.8', 'Deep-layer corticothalamic and 6b': '161.1', 'Deep-layer intratelencephalic': '44.3', 'Deep-layer near-projecting': '39.7', 'Eccentric medium spiny neuron': '8570.1', 'Hippocampal ca1-3': '32.7', 'Hippocampal ca4': '9.7', 'Hippocampal dentate gyrus': '25.1', 'Lamp5-lhx6 and chandelier': '11575.6', 'Lower rhombic lip': '1192.2', 'Mammillary body': '32.7', 'Medium spiny neuron': '1394.4', 'Mge interneuron': '8483.6', 'Midbrain-derived inhibitory': '120.7', 'Miscellaneous': '330.7', 'Splatter': '2055.3', 'Thalamic excitatory': '115.4', 'Upper rhombic lip': '1183.4', 'Upper-layer intratelencephalic': '37.6', 'Astrocyte': '3770.2', 'Bergmann glia': '1997.7', 'Central nervous system macrophage': '41.4', 'Choroid plexus epithelial cell': '408.5', 'Committed oligodendrocyte precursor': '3149.7', 'Ependymal cell': '2292.5', 'Oligodendrocyte': '1798.7', 'Oligodendrocyte precursor cell': '3808.6', 'Endothelial cell': '46.0', 'Pericyte': '69.0', 'Vascular associated smooth muscle cell': '562.4', 'Fibroblast': '63.5', 'Leukocyte': '46.1', 'Basophil': '0.0', 'Eosinophil': '0.0', 'Neutrophil': '0.0', 'Classical monocyte': '0.0', 'Non-classical monocyte': '0.0', 'Intermediate monocyte': '0.0', 'T-reg': '0.0', 'GdT-cell': '0.0', 'MAIT T-cell': '0.0', 'Memory CD4 T-cell': '0.0', 'Naive CD4 T-cell': '0.0', 'Memory CD8 T-cell': '0.0', 'Naive CD8 T-cell': '0.0', 'Memory B-cell': '0.0', 'Naive B-cell': '0.0', 'Plasmacytoid DC': '0.0', 'Myeloid DC': '0.0', 'NK-cell': '0.0', 'Total PBMC': '0.0', 'Vd2 gdTCR': '0.0', 'Memory CD4 T-cell Th1\\/Th17': '0.0', 'Memory CD4 T-cell Th17': '0.0', 'Memory CD4 T-cell Th2': '0.0', 'Non-Vd2 gdTCR': '0.0', 'Memory CD4 T-cell Th1': '0.0', 'Memory CD4 T-cell TFH': '0.0', 'Terminal effector memory CD4 T-cell': '0.0', 'Central memory CD8 T-cell': '0.0', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '0.0', 'Non-switched memory B-cell': '0.0', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.0', 'Exhausted memory B-cell': '0.0', 'Progenitor cell': '0.0', 'Memory T-reg': '0.0', 'Naive CD4 T-cell activated': '0.0', 'Naive CD8 T-cell activated': '0.0', 'Naive T-reg': '0.0'}
2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U, 8U4I, 8U4J, 8U4K, 8U4L
{'Adipose Tissue': 0.3812826387043189, 'Adrenal Gland': 0.1074241162790697, 'Bladder': 0.2619505238095238, 'Blood': 0.0089877201291711, 'Blood Vessel': 4.833504868913858, 'Brain': 6.451171196063588, 'Breast': 3.3113276209150326, 'Cervix Uteri': 1.0675215789473682, 'Colon': 0.1006024313222079, 'Esophagus': 0.0905226996539792, 'Fallopian Tube': 11.173333333333334, 'Heart': 1.5844851184668989, 'Kidney': 3.2344685393258428, 'Liver': 0.0179609336283185, 'Lung': 1.3194758650519032, 'Muscle': 0.8907386052303861, 'Nerve': 1.271967689822294, 'Ovary': 0.2119868333333333, 'Pancreas': 0.3690128048780488, 'Pituitary': 5.2564667844522965, 'Prostate': 0.3224207346938775, 'Salivary Gland': 2.7846685185185187, 'Skin': 0.3008394632393587, 'Small Intestine': 0.0590433636363636, 'Spleen': 0.0745424107883817, 'Stomach': 0.4317559721448468, 'Testis': 5.409421052631579, 'Thyroid': 2.26434134762634, 'Uterus': 0.1600107746478873, 'Vagina': 0.1911400769230769}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
73.038341
0.465153
258
O60260
Q15388
22199232, UNIPROT
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
TOMM20
MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE
Homo sapiens
Mitochondrion outer membrane
Low tissue specificity
{'Ciliated cells': '147.0', 'Basal respiratory cells': '140.8', 'Club cells': '173.2', 'Ionocytes': '86.1', 'Mucus glandular cells': '247.3', 'Serous glandular cells': '368.9', 'Gastric mucus-secreting cells': '127.3', 'Proximal enterocytes': '228.8', 'Paneth cells': '180.3', 'Distal enterocytes': '113.7', 'Intestinal goblet cells': '193.6', 'Exocrine glandular cells': '-0.511', 'Basal prostatic cells': '225.3', 'Prostatic glandular cells': '250.6', 'Breast glandular cells': '0.575', 'Breast myoepithelial cells': '0.510', 'Glandular and luminal cells': '222.3', 'Secretory cells': '388.3', 'Basal keratinocytes': '266.4', 'Suprabasal keratinocytes': '277.6', 'Basal squamous epithelial cells': '263.9', 'Squamous epithelial cells': '263.3', 'Alveolar cells type 1': '0.234', 'Alveolar cells type 2': '0.126', 'Salivary duct cells': '239.1', 'Ductal cells': '0.428', 'Hepatocytes': '0.333', 'Cholangiocytes': '146.9', 'Proximal tubular cells': '0.129', 'Distal tubular cells': '107.6', 'Collecting duct cells': '46.7', 'Mesothelial cells': '0.416', 'Sertoli cells': '0.413', 'Granulosa cells': '183.6', 'Enteroendocrine cells': '162.2', 'Pancreatic endocrine cells': '185.1', 'Leydig cells': '0.490', 'Excitatory neurons': '66.7', 'Inhibitory neurons': '58.5', 'Cone photoreceptor cells': '90.1', 'Rod photoreceptor cells': '39.4', 'Bipolar cells': '48.5', 'Horizontal cells': '41.5', 'Astrocytes': '23.8', 'Oligodendrocyte precursor cells': '24.5', 'Oligodendrocytes': '52.0', 'Microglial cells': '26.8', 'Muller glia cells': '138.0', 'Schwann cells': '0.132', 'Spermatogonia': '0.452', 'Spermatocytes': '0.081', 'Early spermatids': '-0.117', 'Late spermatids': '-0.491', 'Oocytes': '133.8', 'Cytotrophoblasts': '176.4', 'Syncytiotrophoblasts': '194.3', 'Extravillous trophoblasts': '496.9', 'Endothelial cells': '153.9', 'Lymphatic endothelial cells': '171.1', 'Cardiomyocytes': '0.679', 'Skeletal myocytes': '-0.114', 'Smooth muscle cells': '202.5', 'Adipocytes': '157.0', 'Melanocytes': '0.028', 'Fibroblasts': '147.2', 'Peritubular cells': '0.483', 'Endometrial stromal cells': '239.5', 'Ovarian stromal cells': '177.5', 'Undifferentiated cells': '260.5', 'T-cells': '198.4', 'B-cells': '193.1', 'Plasma cells': '190.6', 'Nk-cells': '148.1', 'Granulocytes': '284.1', 'Monocytes': '269.9', 'Macrophages': '173.5', 'Hofbauer cells': '169.2', 'Kupffer cells': '166.3', 'Dendritic cells': '270.9', 'Langerhans cells': '0.163', 'Erythroid cells': '-0.040', 'Adipocytes (Subcutaneous)': '0.006', 'Adipocytes (Visceral)': '-0.098', 'Breast glandular cells (progenitors)': '0.533', 'Adipocytes (Breast)': '-0.398', 'Colon enterocytes': '-0.185', 'Colon enteroendocrine cells': '0.274', 'Enteric glia cells': '-0.034', 'Mitotic cells (Colon)': '-0.116', 'Mitotic cells (Heart)': '0.430', 'Podocytes': '0.146', 'Ascending Loop of Henle cells': '0.354', 'Intercalated cells': '0.144', 'Cholangiocyte': '0.279', 'NK-cells (Liver)': '-0.253', 'Respiratory ciliated cells': '-0.005', 'Mitotic cells (Lung)': '-0.078', 'NK-cells (Lung)': '-0.150', 'B-cells (Lung)': '-0.151', 'Alpha cells': '0.222', 'Beta cells': '0.086', 'Prostate glandular cells': '0.067', 'Prostate basal glandular cells': '0.173', 'Urothelial cells': '0.074', 'Keratinocyte (other)': '0.050', 'Keratinocyte (granular)': '0.001', 'Hair cortex cells': '-0.088', 'Inner root sheath cells': '0.033', 'Outer root sheath cells': '-0.007', 'Sebaceous gland cells': '0.204', 'Eccrine sweat gland cells': '0.016', 'Adipocytes (Skin)': '0.036', 'Mitotic cells (Skin)': '0.101', 'Parietal cells': '-0.278', 'Chief cells': '-0.063', 'Gastric mucous cells': '-0.293', 'Gastric enteroendocrine cells': '-0.154', 'Mitotic cells (Stomach)': '-0.113', 'Parafollicular cells': '0.158', 'Thyroid glandular cells': '0.492', 'Mitotic cells (Thyroid)': '-0.052', 'Adrenal cortex cells': '0.481', 'Adrenal medulla cells': '0.064', 'Mitotic cells (Adrenal gland)': '0.200', 'Minor salivary glandular cells': '0.551', 'Minor salivary gland ductal cells': '0.249', 'Minor salivary gland basal cells': '0.078', 'Mitotic cells (Minor salivary gland)': '-0.014', 'Adipocytes (Minor salivary gland)': '0.089', 'Somatotropes': '0.121', 'Lactotropes': '0.145', 'Gonadotropes': '-0.004', 'Corticotropes': '0.085', 'Thyrotropes': '0.209', 'Undifferentiated cells (Pituitary gland)': '-0.024', 'Mitotic cells (Spleen)': '-0.349', 'Platelets': '-0.232', 'Erythrocytes': '-0.224', 'Hematopoietic stem cells': '-0.244', 'B-cells (Spleen)': '0.371', 'NK-cells (Spleen)': '0.227', 'Amygdala excitatory': '94.9', 'Cerebellar inhibitory': '72.4', 'Cge interneuron': '99.4', 'Deep-layer corticothalamic and 6b': '106.4', 'Deep-layer intratelencephalic': '100.6', 'Deep-layer near-projecting': '125.3', 'Eccentric medium spiny neuron': '141.7', 'Hippocampal ca1-3': '89.5', 'Hippocampal ca4': '72.0', 'Hippocampal dentate gyrus': '107.0', 'Lamp5-lhx6 and chandelier': '110.1', 'Lower rhombic lip': '107.6', 'Mammillary body': '88.7', 'Medium spiny neuron': '118.6', 'Mge interneuron': '108.8', 'Midbrain-derived inhibitory': '131.2', 'Miscellaneous': '110.5', 'Splatter': '117.9', 'Thalamic excitatory': '106.7', 'Upper rhombic lip': '75.0', 'Upper-layer intratelencephalic': '100.8', 'Astrocyte': '27.0', 'Bergmann glia': '28.5', 'Central nervous system macrophage': '37.7', 'Choroid plexus epithelial cell': '52.1', 'Committed oligodendrocyte precursor': '56.8', 'Ependymal cell': '48.2', 'Oligodendrocyte': '81.4', 'Oligodendrocyte precursor cell': '49.7', 'Endothelial cell': '46.3', 'Pericyte': '54.9', 'Vascular associated smooth muscle cell': '66.9', 'Fibroblast': '45.4', 'Leukocyte': '52.0', 'Basophil': '39.3', 'Eosinophil': '6.6', 'Neutrophil': '10.9', 'Classical monocyte': '132.6', 'Non-classical monocyte': '134.5', 'Intermediate monocyte': '71.6', 'T-reg': '78.0', 'GdT-cell': '19.5', 'MAIT T-cell': '103.2', 'Memory CD4 T-cell': '25.0', 'Naive CD4 T-cell': '249.6', 'Memory CD8 T-cell': '24.4', 'Naive CD8 T-cell': '224.0', 'Memory B-cell': '23.2', 'Naive B-cell': '159.0', 'Plasmacytoid DC': '130.5', 'Myeloid DC': '81.9', 'NK-cell': '118.0', 'Total PBMC': '69.1', 'Vd2 gdTCR': '88.2', 'Memory CD4 T-cell TFH': '176.6', 'Memory CD4 T-cell Th2': '215.4', 'Memory CD4 T-cell Th17': '198.8', 'Memory CD4 T-cell Th1\\/Th17': '238.5', 'Non-Vd2 gdTCR': '79.1', 'Memory CD4 T-cell Th1': '189.9', 'Terminal effector memory CD4 T-cell': '108.0', 'Central memory CD8 T-cell': '113.2', 'Effector memory CD8 T-cell': '84.8', 'Terminal effector memory CD8 T-cell': '82.4', 'Switched memory B-cell': '68.8', 'Plasmablast': '64.3', 'Non-switched memory B-cell': '64.4', 'Exhausted memory B-cell': '59.4', 'Progenitor cell': '94.5', 'Naive CD4 T-cell activated': '280.1', 'Naive CD8 T-cell activated': '222.2', 'Memory T-reg': '142.3', 'Naive T-reg': '242.5'}
4APO, 7VBY, 7VC9
{'Adipose Tissue': 107.15420265780732, 'Adrenal Gland': 93.12670542635658, 'Bladder': 111.84952380952382, 'Blood': 42.8634068891281, 'Blood Vessel': 152.4900449438202, 'Brain': 125.2054072672218, 'Breast': 118.0149891067538, 'Cervix Uteri': 145.94894736842105, 'Colon': 91.41779204107831, 'Esophagus': 86.46125951557093, 'Fallopian Tube': 147.62222222222223, 'Heart': 47.5342299651568, 'Kidney': 65.36820224719102, 'Liver': 33.43116371681416, 'Lung': 101.94235294117648, 'Muscle': 65.70656288916564, 'Nerve': 138.85090468497577, 'Ovary': 165.35633333333334, 'Pancreas': 63.227164634146334, 'Pituitary': 107.96996466431096, 'Prostate': 100.42673469387756, 'Salivary Gland': 108.56962962962962, 'Skin': 141.1760917634052, 'Small Intestine': 71.87588235294118, 'Spleen': 60.9756846473029, 'Stomach': 87.74649025069638, 'Testis': 60.979944598337944, 'Thyroid': 142.16295558958652, 'Uterus': 139.78845070422534, 'Vagina': 118.1873076923077}
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[59.34, 66.6, 71.41, 77.05, 81.35, 79.58, 84.67, 86.79, 86.46, 88.56, 89.96, 91.68, 90.25, 90.38, 92.48, 92.35, 92.47, 92.75, 91.03, 89.9, 90.72, 89.18, 87.0, 85.13, 86.62, 81.11, 77.83, 73.19, 69.0, 64.18, 65.2, 64.24, 66.24, 65.8, 68.52, 70.73, 72.48, 75.7, 80.26, 81.95, 80.38, 82.53, 82.36, 81.26, 78.2, 79.05, 76.39, 72.29, 69.88, 65.52, 62.85, 57.56, 54.43, 54.05, 49.95, 56.67, 59.32, 58.76, 62.3, 65.06, 68.49, 78.42, 80.73, 83.46, 81.67, 83.15, 83.85, 86.47, 87.41, 88.28, 88.89, 90.2, 89.19, 89.04, 90.48, 90.14, 89.44, 87.72, 90.73, 90.14, 87.84, 87.72, 90.42, 86.77, 88.13, 87.15, 86.26, 86.2, 87.92, 87.39, 87.54, 89.37, 87.7, 85.16, 84.67, 86.13, 84.14, 81.68, 81.46, 77.18, 77.62, 76.7, 77.31, 76.06, 79.79, 80.77, 81.19, 80.57, 84.29, 83.29, 81.05, 83.81, 84.64, 81.4, 81.92, 81.31, 82.55, 81.56, 83.31, 80.75, 81.75, 82.0, 79.35, 80.08, 71.44, 69.2, 64.16, 60.61, 57.7, 52.54, 54.11, 53.87, 55.12, 51.55, 52.95, 52.03, 50.1, 49.05, 52.31, 53.88, 51.76, 50.93, 52.44, 53.17, 40.28]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
76.482414
0.509724
2,901
O60260
Q16342
22199232, BioGrid hUbiquitome
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
PDCD2
MAAAGARPVELGFAESAPAWRLRSEQFPSKVGGRPAWLGAAGLPGPQALACELCGRPLSFLLQVYAPLPGRPDAFHRCIFLFCCREQPCCAGLRVFRNQLPRKNDFYSYEPPSENPPPETGESVCLQLKSGAHLCRVCGCLGPKTCSRCHKAYYCSKEHQTLDWRLGHKQACAQPDHLDHIIPDHNFLFPEFEIVIETEDEIMPEVVEKEDYSEIIGSMGEALEEELDSMAKHESREDKIFQKFKTQIALEPEQILRYGRGIAPIWISGENIPQEKDIPDCPCGAKRILEFQVMPQLLNYLKADRLGKSIDWGILAVFTCAESCSLGTGYTEEFVWKQDVTDTP
Homo sapiens
Nucleus
Low tissue specificity
{'Ciliated cells': '33.4', 'Basal respiratory cells': '12.5', 'Club cells': '37.3', 'Ionocytes': '13.6', 'Mucus glandular cells': '32.5', 'Serous glandular cells': '45.8', 'Gastric mucus-secreting cells': '30.1', 'Proximal enterocytes': '47.1', 'Paneth cells': '43.7', 'Distal enterocytes': '38.6', 'Intestinal goblet cells': '40.8', 'Exocrine glandular cells': '-0.747', 'Basal prostatic cells': '40.9', 'Prostatic glandular cells': '40.3', 'Breast glandular cells': '0.372', 'Breast myoepithelial cells': '0.151', 'Glandular and luminal cells': '35.9', 'Secretory cells': '71.9', 'Basal keratinocytes': '58.4', 'Suprabasal keratinocytes': '59.8', 'Basal squamous epithelial cells': '49.9', 'Squamous epithelial cells': '58.0', 'Alveolar cells type 1': '0.017', 'Alveolar cells type 2': '0.085', 'Salivary duct cells': '31.7', 'Ductal cells': '0.554', 'Hepatocytes': '0.362', 'Cholangiocytes': '57.2', 'Proximal tubular cells': '0.173', 'Distal tubular cells': '73.8', 'Collecting duct cells': '27.2', 'Mesothelial cells': '0.061', 'Sertoli cells': '0.455', 'Granulosa cells': '44.0', 'Enteroendocrine cells': '44.3', 'Pancreatic endocrine cells': '40.8', 'Leydig cells': '0.555', 'Excitatory neurons': '12.7', 'Inhibitory neurons': '12.1', 'Cone photoreceptor cells': '27.2', 'Rod photoreceptor cells': '37.2', 'Bipolar cells': '32.5', 'Horizontal cells': '20.1', 'Astrocytes': '9.0', 'Oligodendrocyte precursor cells': '7.5', 'Oligodendrocytes': '11.6', 'Microglial cells': '8.1', 'Muller glia cells': '32.1', 'Schwann cells': '0.107', 'Spermatogonia': '0.447', 'Spermatocytes': '0.179', 'Early spermatids': '-0.281', 'Late spermatids': '-0.646', 'Oocytes': '38.2', 'Cytotrophoblasts': '66.6', 'Syncytiotrophoblasts': '47.6', 'Extravillous trophoblasts': '75.2', 'Endothelial cells': '43.2', 'Lymphatic endothelial cells': '30.0', 'Cardiomyocytes': '0.538', 'Skeletal myocytes': '-0.367', 'Smooth muscle cells': '37.4', 'Adipocytes': '43.8', 'Melanocytes': '-0.079', 'Fibroblasts': '38.6', 'Peritubular cells': '0.486', 'Endometrial stromal cells': '38.4', 'Ovarian stromal cells': '44.6', 'Undifferentiated cells': '81.7', 'T-cells': '58.6', 'B-cells': '54.0', 'Plasma cells': '61.2', 'Nk-cells': '79.0', 'Granulocytes': '48.7', 'Monocytes': '50.3', 'Macrophages': '41.6', 'Hofbauer cells': '46.5', 'Kupffer cells': '36.0', 'Dendritic cells': '74.3', 'Langerhans cells': '0.095', 'Erythroid cells': '-0.099', 'Adipocytes (Subcutaneous)': '0.141', 'Adipocytes (Visceral)': '0.113', 'Breast glandular cells (progenitors)': '0.218', 'Adipocytes (Breast)': '-0.119', 'Colon enterocytes': '-0.085', 'Colon enteroendocrine cells': '0.251', 'Enteric glia cells': '-0.088', 'Mitotic cells (Colon)': '0.005', 'Mitotic cells (Heart)': '0.525', 'Podocytes': '0.003', 'Ascending Loop of Henle cells': '0.422', 'Intercalated cells': '0.055', 'Cholangiocyte': '0.279', 'NK-cells (Liver)': '-0.318', 'Respiratory ciliated cells': '-0.043', 'Mitotic cells (Lung)': '0.069', 'NK-cells (Lung)': '-0.070', 'B-cells (Lung)': '-0.220', 'Alpha cells': '0.304', 'Beta cells': '0.149', 'Prostate glandular cells': '-0.072', 'Prostate basal glandular cells': '0.375', 'Urothelial cells': '0.320', 'Keratinocyte (other)': '-0.158', 'Keratinocyte (granular)': '-0.066', 'Hair cortex cells': '0.119', 'Inner root sheath cells': '0.143', 'Outer root sheath cells': '0.185', 'Sebaceous gland cells': '0.217', 'Eccrine sweat gland cells': '0.089', 'Adipocytes (Skin)': '0.187', 'Mitotic cells (Skin)': '0.108', 'Parietal cells': '-0.341', 'Chief cells': '-0.080', 'Gastric mucous cells': '-0.164', 'Gastric enteroendocrine cells': '-0.091', 'Mitotic cells (Stomach)': '0.142', 'Parafollicular cells': '0.136', 'Thyroid glandular cells': '0.422', 'Mitotic cells (Thyroid)': '-0.040', 'Adrenal cortex cells': '0.364', 'Adrenal medulla cells': '0.011', 'Mitotic cells (Adrenal gland)': '0.257', 'Minor salivary glandular cells': '0.659', 'Minor salivary gland ductal cells': '0.130', 'Minor salivary gland basal cells': '0.305', 'Mitotic cells (Minor salivary gland)': '0.326', 'Adipocytes (Minor salivary gland)': '0.151', 'Somatotropes': '-0.108', 'Lactotropes': '-0.124', 'Gonadotropes': '-0.058', 'Corticotropes': '-0.077', 'Thyrotropes': '0.121', 'Undifferentiated cells (Pituitary gland)': '0.294', 'Mitotic cells (Spleen)': '-0.147', 'Platelets': '-0.191', 'Erythrocytes': '-0.132', 'Hematopoietic stem cells': '-0.304', 'B-cells (Spleen)': '0.470', 'NK-cells (Spleen)': '0.279', 'Amygdala excitatory': '17.3', 'Cerebellar inhibitory': '21.7', 'Cge interneuron': '22.2', 'Deep-layer corticothalamic and 6b': '20.9', 'Deep-layer intratelencephalic': '20.2', 'Deep-layer near-projecting': '20.3', 'Eccentric medium spiny neuron': '18.3', 'Hippocampal ca1-3': '18.8', 'Hippocampal ca4': '26.9', 'Hippocampal dentate gyrus': '26.9', 'Lamp5-lhx6 and chandelier': '25.2', 'Lower rhombic lip': '22.2', 'Mammillary body': '20.8', 'Medium spiny neuron': '19.0', 'Mge interneuron': '18.7', 'Midbrain-derived inhibitory': '20.5', 'Miscellaneous': '20.1', 'Splatter': '20.3', 'Thalamic excitatory': '19.4', 'Upper rhombic lip': '21.8', 'Upper-layer intratelencephalic': '18.7', 'Astrocyte': '14.2', 'Bergmann glia': '17.7', 'Central nervous system macrophage': '33.2', 'Choroid plexus epithelial cell': '13.5', 'Committed oligodendrocyte precursor': '17.6', 'Ependymal cell': '15.3', 'Oligodendrocyte': '21.0', 'Oligodendrocyte precursor cell': '19.7', 'Endothelial cell': '29.4', 'Pericyte': '26.3', 'Vascular associated smooth muscle cell': '22.3', 'Fibroblast': '20.9', 'Leukocyte': '30.1', 'Basophil': '32.5', 'Eosinophil': '11.6', 'Neutrophil': '14.3', 'Classical monocyte': '22.8', 'Non-classical monocyte': '31.2', 'Intermediate monocyte': '51.6', 'T-reg': '57.9', 'GdT-cell': '14.1', 'MAIT T-cell': '68.1', 'Memory CD4 T-cell': '16.0', 'Naive CD4 T-cell': '61.2', 'Memory CD8 T-cell': '14.9', 'Naive CD8 T-cell': '53.7', 'Memory B-cell': '14.3', 'Naive B-cell': '34.8', 'Plasmacytoid DC': '58.0', 'Myeloid DC': '58.0', 'NK-cell': '53.5', 'Total PBMC': '53.8', 'Vd2 gdTCR': '69.6', 'Memory CD4 T-cell Th1\\/Th17': '49.3', 'Memory CD4 T-cell Th17': '47.1', 'Memory CD4 T-cell Th2': '46.0', 'Non-Vd2 gdTCR': '50.2', 'Memory CD4 T-cell Th1': '43.0', 'Memory CD4 T-cell TFH': '42.7', 'Terminal effector memory CD4 T-cell': '47.1', 'Central memory CD8 T-cell': '47.9', 'Effector memory CD8 T-cell': '63.0', 'Terminal effector memory CD8 T-cell': '64.9', 'Non-switched memory B-cell': '44.7', 'Plasmablast': '95.1', 'Switched memory B-cell': '47.5', 'Exhausted memory B-cell': '64.5', 'Progenitor cell': '55.7', 'Memory T-reg': '39.5', 'Naive CD4 T-cell activated': '109.8', 'Naive CD8 T-cell activated': '102.9', 'Naive T-reg': '52.3'}
null
{'Adipose Tissue': 16.497615448504984, 'Adrenal Gland': 13.356841085271318, 'Bladder': 19.127142857142857, 'Blood': 9.896184284176536, 'Blood Vessel': 18.326545318352057, 'Brain': 8.180165404996215, 'Breast': 17.944540305010893, 'Cervix Uteri': 19.27578947368421, 'Colon': 15.209629011553274, 'Esophagus': 15.978763321799306, 'Fallopian Tube': 19.716666666666665, 'Heart': 6.019531823461092, 'Kidney': 10.853157303370788, 'Liver': 7.046283185840708, 'Lung': 17.357960207612457, 'Muscle': 10.11694396014944, 'Nerve': 18.18045234248789, 'Ovary': 18.509722222222223, 'Pancreas': 11.448521341463412, 'Pituitary': 13.938381625441696, 'Prostate': 17.34748163265306, 'Salivary Gland': 15.377641975308642, 'Skin': 17.492538419016032, 'Small Intestine': 16.052363636363637, 'Spleen': 18.148663900414935, 'Stomach': 15.345267409470752, 'Testis': 12.558285318559555, 'Thyroid': 20.500410413476263, 'Uterus': 20.529084507042253, 'Vagina': 17.331692307692308}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
84.954244
0.379651
2,203
O60260
Q16665
29180628, 23503661
UbiBrowser, DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
HIF1A
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
Homo sapiens
Cytoplasm, Nucleus, Nucleus speckle
Tissue enhanced (bone)
{'Ciliated cells': '57.6', 'Basal respiratory cells': '96.6', 'Club cells': '49.2', 'Ionocytes': '43.1', 'Mucus glandular cells': '128.0', 'Serous glandular cells': '51.8', 'Gastric mucus-secreting cells': '49.5', 'Proximal enterocytes': '16.3', 'Paneth cells': '16.4', 'Distal enterocytes': '32.5', 'Intestinal goblet cells': '37.0', 'Exocrine glandular cells': '-0.630', 'Basal prostatic cells': '195.3', 'Prostatic glandular cells': '39.0', 'Breast glandular cells': '0.139', 'Breast myoepithelial cells': '0.329', 'Glandular and luminal cells': '275.6', 'Secretory cells': '217.4', 'Basal keratinocytes': '102.6', 'Suprabasal keratinocytes': '103.0', 'Basal squamous epithelial cells': '101.3', 'Squamous epithelial cells': '129.7', 'Alveolar cells type 1': '-0.212', 'Alveolar cells type 2': '-0.123', 'Salivary duct cells': '75.7', 'Ductal cells': '0.717', 'Hepatocytes': '0.345', 'Cholangiocytes': '78.2', 'Proximal tubular cells': '0.153', 'Distal tubular cells': '135.2', 'Collecting duct cells': '260.6', 'Mesothelial cells': '-0.038', 'Sertoli cells': '0.566', 'Granulosa cells': '101.6', 'Enteroendocrine cells': '59.2', 'Pancreatic endocrine cells': '198.7', 'Leydig cells': '0.670', 'Excitatory neurons': '44.0', 'Inhibitory neurons': '37.6', 'Cone photoreceptor cells': '22.1', 'Rod photoreceptor cells': '46.7', 'Bipolar cells': '46.3', 'Horizontal cells': '66.1', 'Astrocytes': '65.6', 'Oligodendrocyte precursor cells': '74.1', 'Oligodendrocytes': '33.3', 'Microglial cells': '51.0', 'Muller glia cells': '115.4', 'Schwann cells': '-0.046', 'Spermatogonia': '0.602', 'Spermatocytes': '0.351', 'Early spermatids': '-0.445', 'Late spermatids': '-0.640', 'Oocytes': '61.0', 'Cytotrophoblasts': '24.5', 'Syncytiotrophoblasts': '24.3', 'Extravillous trophoblasts': '68.2', 'Endothelial cells': '122.0', 'Lymphatic endothelial cells': '142.6', 'Cardiomyocytes': '0.506', 'Skeletal myocytes': '-0.124', 'Smooth muscle cells': '94.7', 'Adipocytes': '91.5', 'Melanocytes': '0.114', 'Fibroblasts': '95.9', 'Peritubular cells': '0.375', 'Endometrial stromal cells': '137.5', 'Ovarian stromal cells': '27.4', 'Undifferentiated cells': '36.8', 'T-cells': '84.3', 'B-cells': '146.5', 'Plasma cells': '50.4', 'Nk-cells': '75.4', 'Granulocytes': '222.5', 'Monocytes': '270.8', 'Macrophages': '279.6', 'Hofbauer cells': '187.0', 'Kupffer cells': '145.6', 'Dendritic cells': '33.3', 'Langerhans cells': '-0.076', 'Erythroid cells': '-0.044', 'Adipocytes (Subcutaneous)': '-0.406', 'Adipocytes (Visceral)': '-0.184', 'Breast glandular cells (progenitors)': '-0.008', 'Adipocytes (Breast)': '-0.347', 'Colon enterocytes': '0.040', 'Colon enteroendocrine cells': '0.139', 'Enteric glia cells': '-0.090', 'Mitotic cells (Colon)': '0.326', 'Mitotic cells (Heart)': '0.519', 'Podocytes': '-0.135', 'Ascending Loop of Henle cells': '0.156', 'Intercalated cells': '-0.251', 'Cholangiocyte': '0.380', 'NK-cells (Liver)': '-0.291', 'Respiratory ciliated cells': '-0.089', 'Mitotic cells (Lung)': '0.080', 'NK-cells (Lung)': '0.083', 'B-cells (Lung)': '0.155', 'Alpha cells': '0.333', 'Beta cells': '0.192', 'Prostate glandular cells': '-0.273', 'Prostate basal glandular cells': '0.007', 'Urothelial cells': '0.104', 'Keratinocyte (other)': '-0.100', 'Keratinocyte (granular)': '-0.451', 'Hair cortex cells': '0.273', 'Inner root sheath cells': '0.345', 'Outer root sheath cells': '0.496', 'Sebaceous gland cells': '0.000', 'Eccrine sweat gland cells': '0.450', 'Adipocytes (Skin)': '0.066', 'Mitotic cells (Skin)': '0.371', 'Parietal cells': '-0.466', 'Chief cells': '-0.381', 'Gastric mucous cells': '-0.107', 'Gastric enteroendocrine cells': '-0.196', 'Mitotic cells (Stomach)': '0.229', 'Parafollicular cells': '0.075', 'Thyroid glandular cells': '0.095', 'Mitotic cells (Thyroid)': '0.116', 'Adrenal cortex cells': '0.398', 'Adrenal medulla cells': '-0.014', 'Mitotic cells (Adrenal gland)': '0.239', 'Minor salivary glandular cells': '0.422', 'Minor salivary gland ductal cells': '-0.120', 'Minor salivary gland basal cells': '0.537', 'Mitotic cells (Minor salivary gland)': '0.606', 'Adipocytes (Minor salivary gland)': '0.072', 'Somatotropes': '-0.306', 'Lactotropes': '-0.328', 'Gonadotropes': '-0.118', 'Corticotropes': '-0.019', 'Thyrotropes': '0.098', 'Undifferentiated cells (Pituitary gland)': '0.336', 'Mitotic cells (Spleen)': '-0.198', 'Platelets': '-0.132', 'Erythrocytes': '-0.252', 'Hematopoietic stem cells': '-0.178', 'B-cells (Spleen)': '0.185', 'NK-cells (Spleen)': '0.157', 'Amygdala excitatory': '62.7', 'Cerebellar inhibitory': '67.0', 'Cge interneuron': '67.2', 'Deep-layer corticothalamic and 6b': '64.8', 'Deep-layer intratelencephalic': '66.6', 'Deep-layer near-projecting': '52.7', 'Eccentric medium spiny neuron': '73.0', 'Hippocampal ca1-3': '62.1', 'Hippocampal ca4': '79.3', 'Hippocampal dentate gyrus': '69.4', 'Lamp5-lhx6 and chandelier': '56.5', 'Lower rhombic lip': '75.8', 'Mammillary body': '61.2', 'Medium spiny neuron': '70.5', 'Mge interneuron': '47.2', 'Midbrain-derived inhibitory': '90.2', 'Miscellaneous': '58.0', 'Splatter': '54.5', 'Thalamic excitatory': '77.7', 'Upper rhombic lip': '119.1', 'Upper-layer intratelencephalic': '57.4', 'Astrocyte': '279.9', 'Bergmann glia': '305.3', 'Central nervous system macrophage': '455.1', 'Choroid plexus epithelial cell': '138.0', 'Committed oligodendrocyte precursor': '91.4', 'Ependymal cell': '50.4', 'Oligodendrocyte': '54.4', 'Oligodendrocyte precursor cell': '119.2', 'Endothelial cell': '209.9', 'Pericyte': '224.2', 'Vascular associated smooth muscle cell': '164.2', 'Fibroblast': '77.0', 'Leukocyte': '281.9', 'Basophil': '138.6', 'Eosinophil': '155.1', 'Neutrophil': '789.9', 'Classical monocyte': '1005.8', 'Non-classical monocyte': '263.6', 'Intermediate monocyte': '155.5', 'T-reg': '85.3', 'GdT-cell': '11.5', 'MAIT T-cell': '80.4', 'Memory CD4 T-cell': '15.0', 'Naive CD4 T-cell': '270.4', 'Memory CD8 T-cell': '13.3', 'Naive CD8 T-cell': '192.8', 'Memory B-cell': '19.6', 'Naive B-cell': '669.8', 'Plasmacytoid DC': '100.0', 'Myeloid DC': '181.6', 'NK-cell': '104.4', 'Total PBMC': '142.3', 'Vd2 gdTCR': '96.5', 'Memory CD4 T-cell TFH': '170.1', 'Memory CD4 T-cell Th2': '164.1', 'Memory CD4 T-cell Th17': '168.6', 'Memory CD4 T-cell Th1\\/Th17': '223.4', 'Non-Vd2 gdTCR': '84.5', 'Memory CD4 T-cell Th1': '191.6', 'Terminal effector memory CD4 T-cell': '85.8', 'Central memory CD8 T-cell': '97.2', 'Effector memory CD8 T-cell': '81.6', 'Terminal effector memory CD8 T-cell': '83.7', 'Switched memory B-cell': '110.3', 'Plasmablast': '67.9', 'Non-switched memory B-cell': '113.3', 'Exhausted memory B-cell': '113.1', 'Progenitor cell': '108.6', 'Naive CD4 T-cell activated': '724.5', 'Naive CD8 T-cell activated': '440.0', 'Memory T-reg': '85.6', 'Naive T-reg': '191.7'}
1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J, 5JWP, 5L9B, 5L9V, 5LA9, 5LAS, 6GFX, 6GMR, 6YW3, 7LVS, 7QGS, 8HE0, 8HE3
{'Adipose Tissue': 91.02975913621265, 'Adrenal Gland': 160.4879457364341, 'Bladder': 72.26761904761904, 'Blood': 84.43241119483316, 'Blood Vessel': 99.6728988764045, 'Brain': 31.575569265707795, 'Breast': 65.82370370370371, 'Cervix Uteri': 71.56947368421052, 'Colon': 43.61186136071887, 'Esophagus': 70.6802276816609, 'Fallopian Tube': 91.62777777777778, 'Heart': 26.260513588850177, 'Kidney': 76.36101123595506, 'Liver': 21.700778761061947, 'Lung': 155.54134948096885, 'Muscle': 9.722001245330013, 'Nerve': 55.99071082390953, 'Ovary': 74.43405555555555, 'Pancreas': 16.31711280487805, 'Pituitary': 60.628197879858654, 'Prostate': 60.55591836734693, 'Salivary Gland': 71.3070987654321, 'Skin': 181.8585903814262, 'Small Intestine': 57.1179679144385, 'Spleen': 78.34730290456432, 'Stomach': 41.65272980501393, 'Testis': 40.81313019390582, 'Thyroid': 94.75473200612556, 'Uterus': 59.57866197183099, 'Vagina': 83.23775641025641}
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[0.99, 0.94, 0.91, 0.72, 0.45, 0.43, 0.5, 0.64, 0.51, 0.73, 0.69, 0.64, 0.51, 0.53, 0.44, 0.59, 0.69, 0.77, 0.69, 0.39, 0.75, 0.58, 0.51, 0.45, 0.52, 0.23, 0.47, 0.59, 0.71, 0.57, 0.59, 0.62, 0.44, 0.32, 0.63, 0.48, 0.24, 0.55, 0.58, 0.33, 0.01, 0.47, 0.77, 0.11, 0.23, 0.07, 0.42, 0.55, 0.54, 0.29, 0.01, 0.37, 0.84, 0.2, 0.61, 0.35, 0.58, 0.14, 0.03, 0.43, 0.18, 0.03, 0.15, 0.47, 0.01, 0.25, 0.61, 0.27, 0.12, 0.48, 0.22, 0.11, 0.39, 0.69, 0.44, 0.46, 0.9, 0.69, 0.77, 0.96, 0.52, 0.65, 0.71, 0.57, 0.53, 0.43, 0.55, 0.44, 0.34, 0.39, 0.54, 0.59, 0.3, 0.71, 0.78, 0.21, 0.54, 0.0, 0.0, 0.25, 0.01, 0.09, 0.0, 0.05, 0.51, 0.68, 0.0, 0.22, 0.0, 0.02, 0.26, 0.0, 0.0, 0.29, 0.15, 0.0, 0.48, 0.75, 0.08, 0.0, 0.18, 0.04, 0.28, 0.07, 0.34, 0.48, 0.0, 0.03, 0.25, 0.32, 0.24, 0.02, 0.22, 0.55, 0.08, 0.04, 0.19, 0.67, 0.76, 0.03, 0.15, 0.65, 0.28, 0.0, 0.45, 0.53, 0.2, 0.05, 0.42, 0.25, 0.7, 0.73, 0.59, 0.91, 0.5, 0.88, 0.95, 0.96, 0.85, 0.97, 0.45, 0.71, 0.28, 0.69, 0.15, 0.59, 0.04, 0.08, 0.02, 0.15, 0.01, 0.24, 0.04, 0.02, 0.25, 0.39, 0.79, 0.84, 0.57, 0.69, 0.63, 0.54, 0.63, 0.47, 0.92, 0.56, 0.3, 0.59, 0.48, 0.24, 0.03, 0.0, 0.18, 0.0, 0.27, 0.21, 0.4, 0.02, 0.41, 0.48, 0.22, 0.5, 0.39, 0.71, 0.91, 0.79, 0.93, 0.57, 0.95, 0.63, 0.88, 0.8, 0.86, 0.7, 0.85, 0.48, 0.16, 0.13, 0.01, 0.01, 0.33, 0.02, 0.36, 0.0, 0.37, 0.19, 0.06, 0.51, 0.4, 0.08, 0.49, 0.52, 0.31, 0.9, 0.83, 0.74, 0.18, 0.5, 0.57, 0.54, 0.04, 0.01, 0.14, 0.02, 0.12, 0.0, 0.3, 0.37, 0.54, 0.02, 0.39, 0.04, 0.4, 0.26, 0.07, 0.1, 0.77, 0.2, 0.0, 0.34, 0.81, 0.15, 0.01, 0.31, 0.06, 0.47, 0.19, 0.82, 0.4, 0.0, 0.48, 0.54, 0.48, 0.19, 0.04, 0.45, 0.36, 0.05, 0.09, 0.07, 0.34, 0.44, 0.13, 0.37, 0.81, 0.5, 0.0, 0.51, 0.61, 0.04, 0.04, 0.65, 0.13, 0.0, 0.48, 0.46, 0.09, 0.11, 0.13, 0.01, 0.14, 0.04, 0.35, 0.57, 0.01, 0.17, 0.01, 0.03, 0.0, 0.14, 0.7, 0.01, 0.0, 0.12, 0.0, 0.3, 0.0, 0.34, 0.04, 0.23, 0.04, 0.02, 0.09, 0.15, 0.49, 0.18, 0.92, 0.75, 0.66, 0.7, 0.68, 0.44, 0.43, 0.12, 0.0, 0.03, 0.04, 0.04, 0.02, 0.32, 0.07, 0.54, 0.23, 0.79, 0.42, 0.35, 0.54, 0.44, 0.57, 0.3, 0.18, 0.25, 0.17, 0.65, 0.3, 0.0, 0.14, 0.57, 0.38, 0.68, 0.73, 0.71, 0.76, 0.86, 0.82, 0.5, 0.73, 0.54, 0.51, 0.72, 0.35, 0.54, 0.67, 0.66, 0.5, 0.66, 0.79, 0.21, 0.84, 0.89, 0.63, 0.71, 0.78, 0.68, 0.31, 0.32, 0.68, 0.5, 0.49, 0.4, 0.66, 0.79, 0.69, 0.6, 0.75, 0.33, 0.49, 0.65, 0.73, 0.58, 0.69, 0.83, 0.59, 0.99, 0.92, 0.57, 0.83, 0.87, 0.75, 0.86, 0.65, 0.91, 0.8, 0.84, 0.9, 0.99, 1.0, 1.0, 1.0, 1.0, 0.99, 1.0, 0.98, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.96, 1.0, 0.95, 1.0, 0.97, 0.99, 0.97, 0.99, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.95, 1.0, 0.95, 0.97, 1.0, 0.98, 1.0, 1.0, 1.0, 0.98, 1.0, 0.97, 0.98, 0.98, 0.95, 0.98, 0.92, 0.96, 0.92, 0.87, 0.93, 0.77, 0.91, 0.65, 0.86, 0.86, 0.81, 0.89, 0.78, 0.63, 0.86, 0.72, 0.81, 0.99, 0.72, 0.78, 0.91, 0.74, 0.84, 0.62, 0.8, 0.43, 0.45, 0.12, 0.49, 0.85, 0.92, 0.78, 0.9, 0.8, 0.89, 0.81, 0.95, 0.92, 0.97, 0.98, 0.98, 1.0, 0.97, 1.0, 0.94, 1.0, 0.98, 0.94, 1.0, 0.93, 0.94, 0.95, 0.91, 0.94, 0.96, 0.95, 0.99, 0.74, 0.97, 0.83, 0.89, 0.82, 0.84, 0.79, 0.93, 0.75, 0.91, 0.61, 0.77, 0.54, 0.46, 0.7, 0.43, 0.42, 0.34, 0.73, 0.54, 0.08, 0.32, 0.47, 0.45, 0.63, 0.83, 0.94, 0.99, 1.0, 0.96, 1.0, 0.96, 0.93, 0.89, 0.89, 0.89, 0.82, 0.96, 0.85, 0.85, 0.91, 0.88, 0.97, 0.92, 0.91, 0.85, 0.88, 0.86, 0.72, 0.95, 0.92, 0.98, 1.0, 0.95, 0.73, 0.93, 0.7, 0.95, 0.83, 0.99, 0.97, 1.0, 0.99, 1.0, 0.99, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.99, 1.0, 0.98, 0.92, 1.0, 0.89, 1.0, 0.91, 0.98, 0.89, 0.97, 0.98, 0.95, 0.94, 0.93, 0.96, 0.97, 0.98, 0.98, 0.98, 0.89, 0.98, 0.92, 1.0, 1.0, 1.0, 1.0, 0.98, 0.98, 0.99, 0.99, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.93, 0.93, 0.94, 0.87, 0.93, 0.94, 0.86, 0.97, 0.95, 0.94, 0.98, 0.92, 1.0, 0.97, 0.99, 0.96, 0.98, 0.91, 0.99, 0.98, 1.0, 1.0, 0.98, 0.98, 0.96, 0.97, 0.98, 1.0, 0.94, 1.0, 0.98, 1.0, 1.0, 0.97, 1.0, 0.97, 0.99, 1.0, 0.99, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.93, 1.0, 0.93, 1.0, 0.98, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.98, 0.99, 0.97, 0.96, 0.91, 0.97, 0.88, 0.93, 0.7, 0.52, 0.74, 0.73, 0.45, 0.56, 0.57, 0.61, 0.55, 0.64, 0.53, 0.72, 0.87, 0.89, 0.9, 0.99, 0.99, 0.97, 0.99, 1.0, 0.98, 0.91, 0.97, 0.94, 0.95, 0.98, 0.95, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 1.0, 0.99, 1.0, 1.0, 0.97, 1.0, 0.98, 1.0, 0.99, 0.93, 0.94, 0.95, 0.87, 0.91, 0.86, 0.85, 0.91, 0.97, 0.92, 1.0, 1.0, 1.0, 1.0, 0.93, 0.94, 0.83, 0.81, 0.85, 0.51, 0.65, 0.62, 0.52, 0.66, 0.42, 0.62, 0.6, 0.59, 0.45, 0.25, 0.25, 0.41, 0.6, 0.55, 0.58, 0.8, 0.56, 0.84, 0.77, 1.0, 0.99, 0.64, 0.73, 0.69, 0.89, 0.26, 0.47, 0.55, 0.75, 0.57, 0.4, 0.74, 0.77, 0.98, 0.86, 0.98, 0.86, 0.97, 0.89, 0.95, 0.96, 1.0, 0.9, 0.64, 0.73, 0.28, 0.66, 0.41, 0.36, 0.38, 0.55, 0.41, 0.46, 0.72, 0.86, 0.8, 0.7]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
60.301138
0.640581
688
O60260
Q3SXM5
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
HSDL1
MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWGANILNRSLRKEALSCTA
Homo sapiens
Mitochondrion
Low tissue specificity
{'Ciliated cells': '14.8', 'Basal respiratory cells': '6.2', 'Club cells': '8.7', 'Ionocytes': '8.8', 'Mucus glandular cells': '9.8', 'Serous glandular cells': '5.8', 'Gastric mucus-secreting cells': '3.5', 'Proximal enterocytes': '3.4', 'Paneth cells': '1.4', 'Distal enterocytes': '2.3', 'Intestinal goblet cells': '4.5', 'Exocrine glandular cells': '-0.536', 'Basal prostatic cells': '5.3', 'Prostatic glandular cells': '5.8', 'Breast glandular cells': '0.648', 'Breast myoepithelial cells': '0.539', 'Glandular and luminal cells': '11.7', 'Secretory cells': '8.2', 'Basal keratinocytes': '6.4', 'Suprabasal keratinocytes': '8.1', 'Basal squamous epithelial cells': '9.3', 'Squamous epithelial cells': '8.4', 'Alveolar cells type 1': '0.087', 'Alveolar cells type 2': '0.278', 'Salivary duct cells': '8.5', 'Ductal cells': '0.615', 'Hepatocytes': '0.264', 'Cholangiocytes': '1.9', 'Proximal tubular cells': '0.105', 'Distal tubular cells': '3.1', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.359', 'Sertoli cells': '0.402', 'Granulosa cells': '12.3', 'Enteroendocrine cells': '6.8', 'Pancreatic endocrine cells': '5.1', 'Leydig cells': '0.447', 'Excitatory neurons': '12.0', 'Inhibitory neurons': '15.1', 'Cone photoreceptor cells': '20.4', 'Rod photoreceptor cells': '37.9', 'Bipolar cells': '20.3', 'Horizontal cells': '27.1', 'Astrocytes': '7.4', 'Oligodendrocyte precursor cells': '14.6', 'Oligodendrocytes': '12.1', 'Microglial cells': '10.7', 'Muller glia cells': '25.7', 'Schwann cells': '0.102', 'Spermatogonia': '0.574', 'Spermatocytes': '0.375', 'Early spermatids': '-0.045', 'Late spermatids': '-0.508', 'Oocytes': '25.0', 'Cytotrophoblasts': '6.9', 'Syncytiotrophoblasts': '11.3', 'Extravillous trophoblasts': '6.8', 'Endothelial cells': '7.7', 'Lymphatic endothelial cells': '8.0', 'Cardiomyocytes': '0.671', 'Skeletal myocytes': '0.054', 'Smooth muscle cells': '8.0', 'Adipocytes': '9.1', 'Melanocytes': '-0.097', 'Fibroblasts': '7.5', 'Peritubular cells': '0.529', 'Endometrial stromal cells': '10.4', 'Ovarian stromal cells': '12.0', 'Undifferentiated cells': '4.8', 'T-cells': '7.0', 'B-cells': '6.9', 'Plasma cells': '9.5', 'Nk-cells': '6.7', 'Granulocytes': '4.1', 'Monocytes': '22.5', 'Macrophages': '7.0', 'Hofbauer cells': '11.5', 'Kupffer cells': '5.2', 'Dendritic cells': '1.6', 'Langerhans cells': '0.116', 'Erythroid cells': '0.046', 'Adipocytes (Subcutaneous)': '-0.104', 'Adipocytes (Visceral)': '-0.188', 'Breast glandular cells (progenitors)': '0.358', 'Adipocytes (Breast)': '-0.498', 'Colon enterocytes': '-0.154', 'Colon enteroendocrine cells': '0.354', 'Enteric glia cells': '0.334', 'Mitotic cells (Colon)': '-0.166', 'Mitotic cells (Heart)': '0.384', 'Podocytes': '-0.120', 'Ascending Loop of Henle cells': '0.523', 'Intercalated cells': '0.021', 'Cholangiocyte': '0.287', 'NK-cells (Liver)': '-0.158', 'Respiratory ciliated cells': '0.138', 'Mitotic cells (Lung)': '0.220', 'NK-cells (Lung)': '-0.077', 'B-cells (Lung)': '-0.129', 'Alpha cells': '0.458', 'Beta cells': '0.300', 'Prostate glandular cells': '-0.139', 'Prostate basal glandular cells': '0.230', 'Urothelial cells': '0.183', 'Keratinocyte (other)': '-0.186', 'Keratinocyte (granular)': '-0.342', 'Hair cortex cells': '0.097', 'Inner root sheath cells': '0.100', 'Outer root sheath cells': '0.318', 'Sebaceous gland cells': '0.157', 'Eccrine sweat gland cells': '0.216', 'Adipocytes (Skin)': '0.174', 'Mitotic cells (Skin)': '0.191', 'Parietal cells': '-0.595', 'Chief cells': '-0.513', 'Gastric mucous cells': '-0.328', 'Gastric enteroendocrine cells': '-0.309', 'Mitotic cells (Stomach)': '0.067', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.438', 'Mitotic cells (Thyroid)': '-0.211', 'Adrenal cortex cells': '0.376', 'Adrenal medulla cells': '0.035', 'Mitotic cells (Adrenal gland)': '0.289', 'Minor salivary glandular cells': '0.568', 'Minor salivary gland ductal cells': '0.199', 'Minor salivary gland basal cells': '0.157', 'Mitotic cells (Minor salivary gland)': '0.180', 'Adipocytes (Minor salivary gland)': '0.041', 'Somatotropes': '0.272', 'Lactotropes': '0.424', 'Gonadotropes': '0.277', 'Corticotropes': '0.184', 'Thyrotropes': '0.336', 'Undifferentiated cells (Pituitary gland)': '-0.139', 'Mitotic cells (Spleen)': '-0.304', 'Platelets': '-0.140', 'Erythrocytes': '-0.139', 'Hematopoietic stem cells': '-0.298', 'B-cells (Spleen)': '0.324', 'NK-cells (Spleen)': '0.367', 'Amygdala excitatory': '20.5', 'Cerebellar inhibitory': '20.8', 'Cge interneuron': '28.1', 'Deep-layer corticothalamic and 6b': '22.7', 'Deep-layer intratelencephalic': '19.3', 'Deep-layer near-projecting': '28.7', 'Eccentric medium spiny neuron': '25.7', 'Hippocampal ca1-3': '17.6', 'Hippocampal ca4': '20.1', 'Hippocampal dentate gyrus': '20.7', 'Lamp5-lhx6 and chandelier': '26.1', 'Lower rhombic lip': '22.2', 'Mammillary body': '27.9', 'Medium spiny neuron': '22.5', 'Mge interneuron': '22.3', 'Midbrain-derived inhibitory': '32.0', 'Miscellaneous': '19.7', 'Splatter': '26.2', 'Thalamic excitatory': '26.2', 'Upper rhombic lip': '16.5', 'Upper-layer intratelencephalic': '14.1', 'Astrocyte': '12.3', 'Bergmann glia': '14.2', 'Central nervous system macrophage': '14.2', 'Choroid plexus epithelial cell': '16.9', 'Committed oligodendrocyte precursor': '14.8', 'Ependymal cell': '20.1', 'Oligodendrocyte': '15.6', 'Oligodendrocyte precursor cell': '25.3', 'Endothelial cell': '19.2', 'Pericyte': '14.9', 'Vascular associated smooth muscle cell': '11.4', 'Fibroblast': '17.6', 'Leukocyte': '11.6', 'Basophil': '38.7', 'Eosinophil': '11.2', 'Neutrophil': '36.3', 'Classical monocyte': '16.1', 'Non-classical monocyte': '29.0', 'Intermediate monocyte': '25.4', 'T-reg': '26.4', 'GdT-cell': '3.8', 'MAIT T-cell': '28.8', 'Memory CD4 T-cell': '4.1', 'Naive CD4 T-cell': '36.2', 'Memory CD8 T-cell': '4.6', 'Naive CD8 T-cell': '33.8', 'Memory B-cell': '5.1', 'Naive B-cell': '36.0', 'Plasmacytoid DC': '3.0', 'Myeloid DC': '9.5', 'NK-cell': '23.4', 'Total PBMC': '25.0', 'Vd2 gdTCR': '28.3', 'Memory CD4 T-cell TFH': '23.9', 'Memory CD4 T-cell Th2': '27.6', 'Memory CD4 T-cell Th17': '25.5', 'Memory CD4 T-cell Th1\\/Th17': '27.7', 'Non-Vd2 gdTCR': '31.8', 'Memory CD4 T-cell Th1': '23.8', 'Terminal effector memory CD4 T-cell': '37.7', 'Central memory CD8 T-cell': '32.5', 'Effector memory CD8 T-cell': '28.9', 'Terminal effector memory CD8 T-cell': '25.2', 'Switched memory B-cell': '23.6', 'Plasmablast': '17.9', 'Non-switched memory B-cell': '30.8', 'Exhausted memory B-cell': '28.5', 'Progenitor cell': '24.0', 'Naive CD4 T-cell activated': '23.7', 'Naive CD8 T-cell activated': '28.2', 'Memory T-reg': '21.5', 'Naive T-reg': '36.8'}
null
{'Adipose Tissue': 13.593617109634552, 'Adrenal Gland': 21.63448062015504, 'Bladder': 17.599333333333334, 'Blood': 4.760002583423036, 'Blood Vessel': 14.662658426966294, 'Brain': 22.043488644965933, 'Breast': 17.287322440087145, 'Cervix Uteri': 28.22421052631579, 'Colon': 14.11263029525032, 'Esophagus': 11.746420069204152, 'Fallopian Tube': 20.153333333333332, 'Heart': 9.76136957026713, 'Kidney': 8.17561797752809, 'Liver': 3.753444247787611, 'Lung': 16.672346020761246, 'Muscle': 13.025400996264011, 'Nerve': 21.844899838449113, 'Ovary': 33.42516666666666, 'Pancreas': 4.371298780487805, 'Pituitary': 35.055865724381626, 'Prostate': 16.95848163265306, 'Salivary Gland': 14.325604938271605, 'Skin': 14.089935323383084, 'Small Intestine': 13.069983957219252, 'Spleen': 17.844792531120333, 'Stomach': 8.75533147632312, 'Testis': 26.713850415512468, 'Thyroid': 40.12370137825421, 'Uterus': 25.0656338028169, 'Vagina': 19.05649358974359}
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[47.93, 56.68, 58.62, 57.39, 61.88, 69.89, 74.19, 77.88, 76.28, 73.48, 75.41, 76.65, 73.04, 70.15, 68.87, 69.21, 67.03, 65.1, 75.76, 78.4, 82.61, 82.95, 83.5, 87.41, 91.72, 91.44, 91.68, 93.53, 94.77, 93.58, 94.21, 93.59, 93.58, 93.53, 93.59, 89.81, 90.35, 92.75, 89.95, 86.78, 89.41, 90.72, 87.09, 86.98, 89.99, 88.37, 88.83, 89.01, 90.38, 91.53, 90.74, 89.1, 84.85, 81.92, 80.71, 82.09, 78.01, 77.96, 83.53, 86.32, 92.79, 95.41, 95.93, 94.75, 94.84, 97.37, 96.33, 97.42, 98.57, 98.74, 98.73, 98.69, 98.02, 95.83, 94.61, 93.03, 92.47, 93.72, 96.29, 97.33, 97.86, 98.09, 98.34, 98.62, 98.49, 97.98, 98.36, 98.42, 97.11, 95.78, 96.81, 98.28, 98.57, 98.7, 98.62, 98.64, 98.29, 96.94, 94.69, 94.89, 97.13, 97.4, 96.45, 97.79, 98.14, 98.15, 98.11, 98.52, 98.45, 98.14, 98.55, 98.48, 98.22, 98.34, 97.99, 98.1, 98.2, 98.29, 98.4, 97.65, 98.18, 97.99, 97.65, 97.2, 96.31, 96.01, 94.39, 93.36, 90.28, 93.58, 93.11, 95.74, 96.59, 95.74, 96.23, 97.44, 96.95, 96.32, 96.42, 97.21, 93.2, 91.01, 94.42, 95.33, 98.1, 98.15, 98.72, 98.78, 98.76, 98.44, 97.75, 95.44, 93.83, 93.75, 92.34, 91.85, 87.49, 89.71, 92.82, 93.22, 94.95, 95.31, 95.87, 94.69, 94.04, 95.85, 96.15, 95.34, 95.34, 95.67, 95.56, 96.13, 96.54, 96.35, 95.5, 97.27, 97.2, 97.85, 97.41, 97.66, 97.51, 97.93, 97.77, 98.27, 98.2, 96.89, 97.34, 97.72, 97.57, 96.44, 96.2, 97.9, 97.6, 96.6, 95.91, 97.3, 97.1, 98.29, 98.65, 98.75, 98.74, 98.59, 97.91, 97.1, 95.84, 93.95, 93.18, 93.79, 91.69, 93.15, 94.96, 94.96, 94.89, 94.23, 95.83, 96.29, 96.84, 96.24, 96.27, 97.56, 97.83, 97.72, 97.84, 98.39, 98.32, 98.14, 98.04, 98.3, 98.5, 98.07, 98.51, 98.46, 98.12, 97.92, 97.97, 98.33, 97.57, 97.45, 97.9, 97.07, 98.44, 98.45, 98.64, 98.52, 98.32, 97.68, 97.36, 96.73, 94.29, 92.32, 92.07, 90.0, 86.23, 79.29, 74.44, 72.17, 66.56, 63.75, 65.56, 69.52, 69.4, 71.93, 68.78, 74.47, 76.05, 83.76, 83.42, 89.23, 90.85, 93.95, 93.88, 95.29, 95.56, 95.48, 96.89, 97.16, 95.14, 95.04, 96.66, 96.05, 93.93, 95.08, 95.58, 93.75, 93.29, 94.55, 95.93, 96.0, 96.19, 96.12, 95.15, 95.74, 93.62, 93.36, 95.68, 93.78, 91.81, 92.65, 93.07, 90.65, 89.56, 91.03, 87.86, 87.39, 89.93, 93.7, 94.66, 95.39, 95.19, 94.66, 95.33, 95.51, 94.14, 93.58, 94.16, 94.14, 92.14, 93.28, 92.65, 91.38, 90.3, 90.13, 91.03, 88.1, 86.93, 88.1, 87.41, 78.91, 73.84, 64.83]
[0.99, 0.98, 0.87, 0.9, 0.7, 0.66, 0.73, 0.66, 0.58, 0.53, 0.65, 0.51, 0.69, 0.5, 0.41, 0.69, 0.53, 0.39, 0.47, 0.65, 0.68, 0.62, 0.54, 0.43, 0.64, 0.56, 0.67, 0.6, 0.37, 0.5, 0.63, 0.61, 0.58, 0.42, 0.58, 0.42, 0.43, 0.58, 0.37, 0.51, 0.66, 0.49, 0.27, 0.55, 0.59, 0.41, 0.11, 0.41, 0.52, 0.16, 0.02, 0.56, 0.51, 0.27, 0.42, 0.82, 0.68, 0.92, 0.6, 0.4, 0.49, 0.01, 0.32, 0.78, 0.54, 0.08, 0.01, 0.66, 0.09, 0.0, 0.0, 0.0, 0.02, 0.22, 0.01, 0.2, 0.55, 0.15, 0.12, 0.0, 0.25, 0.06, 0.0, 0.0, 0.15, 0.12, 0.0, 0.01, 0.38, 0.18, 0.44, 0.0, 0.16, 0.0, 0.0, 0.0, 0.0, 0.13, 0.66, 0.39, 0.47, 0.65, 0.59, 0.0, 0.51, 0.57, 0.04, 0.08, 0.66, 0.45, 0.01, 0.27, 0.55, 0.78, 0.39, 0.79, 0.14, 0.6, 0.31, 0.34, 0.34, 0.11, 0.51, 0.06, 0.29, 0.02, 0.36, 0.6, 0.32, 0.81, 0.7, 0.15, 0.09, 0.67, 0.58, 0.01, 0.43, 0.65, 0.42, 0.08, 0.7, 0.97, 0.27, 0.31, 0.04, 0.0, 0.0, 0.0, 0.01, 0.04, 0.17, 0.22, 0.37, 0.22, 0.31, 0.04, 0.63, 0.29, 0.04, 0.09, 0.54, 0.54, 0.92, 0.47, 0.11, 0.56, 0.81, 0.71, 0.27, 0.22, 0.62, 0.22, 0.01, 0.51, 0.13, 0.06, 0.01, 0.25, 0.28, 0.01, 0.05, 0.21, 0.35, 0.0, 0.02, 0.64, 0.13, 0.08, 0.08, 0.55, 0.24, 0.0, 0.25, 0.83, 0.44, 0.71, 0.27, 0.0, 0.0, 0.0, 0.0, 0.01, 0.05, 0.04, 0.19, 0.04, 0.11, 0.15, 0.31, 0.16, 0.5, 0.09, 0.3, 0.06, 0.06, 0.45, 0.22, 0.08, 0.07, 0.56, 0.01, 0.06, 0.36, 0.4, 0.01, 0.05, 0.64, 0.2, 0.02, 0.45, 0.36, 0.09, 0.1, 0.83, 0.64, 0.24, 0.42, 0.9, 0.43, 0.43, 0.02, 0.13, 0.01, 0.0, 0.0, 0.0, 0.0, 0.06, 0.17, 0.32, 0.04, 0.14, 0.16, 0.55, 0.55, 0.15, 0.46, 0.43, 0.05, 0.61, 0.74, 0.04, 0.54, 0.72, 0.62, 0.42, 0.63, 0.46, 0.05, 0.04, 0.29, 0.18, 0.66, 0.42, 0.0, 0.0, 0.39, 0.11, 0.0, 0.0, 0.18, 0.0, 0.04, 0.43, 0.46, 0.17, 0.48, 0.36, 0.06, 0.01, 0.0, 0.08, 0.35, 0.0, 0.0, 0.1, 0.31, 0.24, 0.14, 0.2, 0.67, 0.02, 0.5, 0.43, 0.32, 0.51, 0.52, 0.77, 0.41, 0.13, 0.29, 0.61, 0.42, 0.12, 0.24, 0.52, 0.38, 0.02, 0.56, 0.55, 0.15, 0.2, 0.72, 0.2, 0.09, 0.41, 0.62, 0.68, 0.72, 0.81]
null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
92.033242
0.330455
2,264
O60260
Q5SWX8
33082525
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ODR4
MGRTYIVEETVGQYLSNINLQGKAFVSGLLIGQCSSQKDYVILATRTPPKEEQSENLKHPKAKLDNLDEEWATEHACQVSRMLPGGLLVLGVFIITTLELANDFQNALRRLMFAVEKSINRKRLWNFTEEEVSERVTLHICASTKKIFCRTYDIHDPKSSARPADWKYQSGLSSSWLSLECTVHINIHIPLSATSVSYTLEKNTKNGLTRWAKEIENGVYLINGQVKDEDCDLLEGQKKSSRGNTQATSHSFDVRVLTQLLLNSDHRSTATVQICSGSVNLKGAVKCRAYIHSSKPKVKDAVQAVKRDILNTVADRCEMLFEDLLLNEIPEKKDSEKEFHVLPYRVFVPLPGSTVMLCDYKFDDESAEEIRDHFMEMLDHTIQIEDLEIAEETNTACMSSSMNSQASLDNTDDEQPKQPIKTTMLLKIQQNIGVIAAFTVAVLAAGISFHYFSD
Homo sapiens
Membrane
Low tissue specificity
{'Ciliated cells': '21.9', 'Basal respiratory cells': '26.0', 'Club cells': '27.8', 'Ionocytes': '29.5', 'Mucus glandular cells': '29.1', 'Serous glandular cells': '58.3', 'Gastric mucus-secreting cells': '23.6', 'Proximal enterocytes': '21.7', 'Paneth cells': '16.1', 'Distal enterocytes': '17.9', 'Intestinal goblet cells': '19.3', 'Exocrine glandular cells': '-0.613', 'Basal prostatic cells': '36.0', 'Prostatic glandular cells': '55.0', 'Breast glandular cells': '0.469', 'Breast myoepithelial cells': '0.563', 'Glandular and luminal cells': '33.3', 'Secretory cells': '29.7', 'Basal keratinocytes': '21.6', 'Suprabasal keratinocytes': '19.7', 'Basal squamous epithelial cells': '16.2', 'Squamous epithelial cells': '14.4', 'Alveolar cells type 1': '0.127', 'Alveolar cells type 2': '-0.354', 'Salivary duct cells': '26.6', 'Ductal cells': '0.495', 'Hepatocytes': '0.241', 'Cholangiocytes': '21.0', 'Proximal tubular cells': '0.043', 'Distal tubular cells': '0.0', 'Collecting duct cells': '25.3', 'Mesothelial cells': '0.441', 'Sertoli cells': '0.360', 'Granulosa cells': '25.5', 'Enteroendocrine cells': '16.2', 'Pancreatic endocrine cells': '8.5', 'Leydig cells': '0.332', 'Excitatory neurons': '50.7', 'Inhibitory neurons': '44.9', 'Cone photoreceptor cells': '30.6', 'Rod photoreceptor cells': '27.8', 'Bipolar cells': '26.1', 'Horizontal cells': '34.6', 'Astrocytes': '34.7', 'Oligodendrocyte precursor cells': '34.9', 'Oligodendrocytes': '58.3', 'Microglial cells': '34.9', 'Muller glia cells': '24.9', 'Schwann cells': '0.093', 'Spermatogonia': '0.064', 'Spermatocytes': '-0.072', 'Early spermatids': '-0.191', 'Late spermatids': '-0.509', 'Oocytes': '21.3', 'Cytotrophoblasts': '22.3', 'Syncytiotrophoblasts': '33.7', 'Extravillous trophoblasts': '27.8', 'Endothelial cells': '25.9', 'Lymphatic endothelial cells': '30.4', 'Cardiomyocytes': '0.528', 'Skeletal myocytes': '-0.233', 'Smooth muscle cells': '20.0', 'Adipocytes': '26.5', 'Melanocytes': '-0.008', 'Fibroblasts': '23.1', 'Peritubular cells': '0.441', 'Endometrial stromal cells': '25.5', 'Ovarian stromal cells': '21.4', 'Undifferentiated cells': '20.0', 'T-cells': '15.6', 'B-cells': '13.7', 'Plasma cells': '28.8', 'Nk-cells': '20.4', 'Granulocytes': '13.8', 'Monocytes': '16.7', 'Macrophages': '18.4', 'Hofbauer cells': '13.8', 'Kupffer cells': '16.6', 'Dendritic cells': '26.4', 'Langerhans cells': '0.091', 'Erythroid cells': '0.029', 'Adipocytes (Subcutaneous)': '-0.193', 'Adipocytes (Visceral)': '-0.377', 'Breast glandular cells (progenitors)': '0.306', 'Adipocytes (Breast)': '-0.502', 'Colon enterocytes': '-0.143', 'Colon enteroendocrine cells': '0.294', 'Enteric glia cells': '0.634', 'Mitotic cells (Colon)': '-0.008', 'Mitotic cells (Heart)': '0.490', 'Podocytes': '0.009', 'Ascending Loop of Henle cells': '0.454', 'Intercalated cells': '0.062', 'Cholangiocyte': '0.229', 'NK-cells (Liver)': '-0.232', 'Respiratory ciliated cells': '0.099', 'Mitotic cells (Lung)': '-0.112', 'NK-cells (Lung)': '0.300', 'B-cells (Lung)': '0.090', 'Alpha cells': '0.313', 'Beta cells': '0.211', 'Prostate glandular cells': '0.450', 'Prostate basal glandular cells': '0.377', 'Urothelial cells': '0.159', 'Keratinocyte (other)': '-0.026', 'Keratinocyte (granular)': '-0.283', 'Hair cortex cells': '-0.040', 'Inner root sheath cells': '0.042', 'Outer root sheath cells': '0.237', 'Sebaceous gland cells': '0.123', 'Eccrine sweat gland cells': '0.124', 'Adipocytes (Skin)': '-0.066', 'Mitotic cells (Skin)': '0.168', 'Parietal cells': '0.063', 'Chief cells': '0.392', 'Gastric mucous cells': '0.005', 'Gastric enteroendocrine cells': '0.293', 'Mitotic cells (Stomach)': '0.010', 'Parafollicular cells': '0.133', 'Thyroid glandular cells': '0.445', 'Mitotic cells (Thyroid)': '-0.017', 'Adrenal cortex cells': '0.202', 'Adrenal medulla cells': '-0.034', 'Mitotic cells (Adrenal gland)': '0.004', 'Minor salivary glandular cells': '0.400', 'Minor salivary gland ductal cells': '0.397', 'Minor salivary gland basal cells': '-0.174', 'Mitotic cells (Minor salivary gland)': '-0.312', 'Adipocytes (Minor salivary gland)': '-0.136', 'Somatotropes': '0.150', 'Lactotropes': '0.019', 'Gonadotropes': '-0.006', 'Corticotropes': '-0.050', 'Thyrotropes': '0.050', 'Undifferentiated cells (Pituitary gland)': '0.016', 'Mitotic cells (Spleen)': '-0.105', 'Platelets': '-0.223', 'Erythrocytes': '0.000', 'Hematopoietic stem cells': '-0.276', 'B-cells (Spleen)': '0.254', 'NK-cells (Spleen)': '0.370', 'Amygdala excitatory': '72.2', 'Cerebellar inhibitory': '51.1', 'Cge interneuron': '54.7', 'Deep-layer corticothalamic and 6b': '69.5', 'Deep-layer intratelencephalic': '65.1', 'Deep-layer near-projecting': '60.2', 'Eccentric medium spiny neuron': '73.8', 'Hippocampal ca1-3': '77.4', 'Hippocampal ca4': '63.9', 'Hippocampal dentate gyrus': '74.3', 'Lamp5-lhx6 and chandelier': '59.5', 'Lower rhombic lip': '54.2', 'Mammillary body': '65.7', 'Medium spiny neuron': '88.5', 'Mge interneuron': '61.8', 'Midbrain-derived inhibitory': '81.6', 'Miscellaneous': '60.7', 'Splatter': '60.5', 'Thalamic excitatory': '69.5', 'Upper rhombic lip': '63.9', 'Upper-layer intratelencephalic': '70.0', 'Astrocyte': '64.7', 'Bergmann glia': '69.3', 'Central nervous system macrophage': '79.1', 'Choroid plexus epithelial cell': '50.0', 'Committed oligodendrocyte precursor': '63.4', 'Ependymal cell': '45.3', 'Oligodendrocyte': '87.2', 'Oligodendrocyte precursor cell': '72.9', 'Endothelial cell': '92.3', 'Pericyte': '57.4', 'Vascular associated smooth muscle cell': '49.9', 'Fibroblast': '64.6', 'Leukocyte': '40.3', 'Basophil': '27.5', 'Eosinophil': '2.5', 'Neutrophil': '19.9', 'Classical monocyte': '33.3', 'Non-classical monocyte': '27.7', 'Intermediate monocyte': '26.8', 'T-reg': '20.2', 'GdT-cell': '3.0', 'MAIT T-cell': '21.2', 'Memory CD4 T-cell': '3.8', 'Naive CD4 T-cell': '53.7', 'Memory CD8 T-cell': '4.2', 'Naive CD8 T-cell': '43.4', 'Memory B-cell': '3.7', 'Naive B-cell': '43.8', 'Plasmacytoid DC': '38.6', 'Myeloid DC': '29.2', 'NK-cell': '34.6', 'Total PBMC': '21.5', 'Vd2 gdTCR': '23.4', 'Memory CD4 T-cell Th1\\/Th17': '43.4', 'Memory CD4 T-cell Th17': '38.0', 'Memory CD4 T-cell Th2': '42.9', 'Non-Vd2 gdTCR': '22.4', 'Memory CD4 T-cell Th1': '36.1', 'Memory CD4 T-cell TFH': '33.3', 'Terminal effector memory CD4 T-cell': '23.1', 'Central memory CD8 T-cell': '20.9', 'Effector memory CD8 T-cell': '19.7', 'Terminal effector memory CD8 T-cell': '18.8', 'Non-switched memory B-cell': '22.9', 'Plasmablast': '39.9', 'Switched memory B-cell': '19.8', 'Exhausted memory B-cell': '19.0', 'Progenitor cell': '25.5', 'Memory T-reg': '31.4', 'Naive CD4 T-cell activated': '48.5', 'Naive CD8 T-cell activated': '47.3', 'Naive T-reg': '50.5'}
null
{}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
80.953987
0.392203
1,750
O60260
Q5VT66
33082525
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
MTARC1
MGAAGSSALARFVLLAQSRPGWLGVAALGLTAVALGAVAWRRAWPTRRRRLLQQVGTVAQLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVINQEGNMVTARQEPRLVLISLTCDGDTLTLSAAYTKDLLLPIKTPTTNAVHKCRVHGLEIEGRDCGEATAQWITSFLKSQPYRLVHFEPHMRPRRPHQIADLFRPKDQIAYSDTSPFLILSEASLADLNSRLEKKVKATNFRPNIVISGCDVYAEDSWDELLIGDVELKRVMACSRCILTTVDPDTGVMSRKEPLETLKSYRQCDPSERKLYGKSPLFGQYFVLENPGTIKVGDPVYLLGQ
Homo sapiens
Mitochondrion outer membrane, Membrane
Tissue enhanced (adipose tissue, breast, liver)
{'Ciliated cells': '3.8', 'Basal respiratory cells': '0.9', 'Club cells': '4.7', 'Ionocytes': '0.7', 'Mucus glandular cells': '4.4', 'Serous glandular cells': '19.2', 'Gastric mucus-secreting cells': '5.3', 'Proximal enterocytes': '2.8', 'Paneth cells': '6.5', 'Distal enterocytes': '16.7', 'Intestinal goblet cells': '21.2', 'Exocrine glandular cells': '-0.394', 'Basal prostatic cells': '15.0', 'Prostatic glandular cells': '40.0', 'Breast glandular cells': '-0.478', 'Breast myoepithelial cells': '-0.614', 'Glandular and luminal cells': '30.5', 'Secretory cells': '4.8', 'Basal keratinocytes': '1.2', 'Suprabasal keratinocytes': '4.4', 'Basal squamous epithelial cells': '4.7', 'Squamous epithelial cells': '9.9', 'Alveolar cells type 1': '0.122', 'Alveolar cells type 2': '0.358', 'Salivary duct cells': '3.2', 'Ductal cells': '0.425', 'Hepatocytes': '0.539', 'Cholangiocytes': '3.8', 'Proximal tubular cells': '0.065', 'Distal tubular cells': '0.0', 'Collecting duct cells': '7.8', 'Mesothelial cells': '-0.281', 'Sertoli cells': '0.037', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '8.0', 'Pancreatic endocrine cells': '1.7', 'Leydig cells': '0.150', 'Excitatory neurons': '8.5', 'Inhibitory neurons': '8.9', 'Cone photoreceptor cells': '3.4', 'Rod photoreceptor cells': '0.9', 'Bipolar cells': '6.3', 'Horizontal cells': '4.4', 'Astrocytes': '18.6', 'Oligodendrocyte precursor cells': '9.9', 'Oligodendrocytes': '1.5', 'Microglial cells': '1.8', 'Muller glia cells': '16.9', 'Schwann cells': '0.207', 'Spermatogonia': '0.022', 'Spermatocytes': '-0.255', 'Early spermatids': '-0.213', 'Late spermatids': '-0.162', 'Oocytes': '0.7', 'Cytotrophoblasts': '111.2', 'Syncytiotrophoblasts': '73.3', 'Extravillous trophoblasts': '43.8', 'Endothelial cells': '4.9', 'Lymphatic endothelial cells': '3.5', 'Cardiomyocytes': '0.592', 'Skeletal myocytes': '0.285', 'Smooth muscle cells': '5.2', 'Adipocytes': '26.3', 'Melanocytes': '-0.207', 'Fibroblasts': '3.3', 'Peritubular cells': '0.440', 'Endometrial stromal cells': '2.4', 'Ovarian stromal cells': '2.5', 'Undifferentiated cells': '21.5', 'T-cells': '0.5', 'B-cells': '0.6', 'Plasma cells': '1.1', 'Nk-cells': '0.0', 'Granulocytes': '0.9', 'Monocytes': '0.0', 'Macrophages': '4.8', 'Hofbauer cells': '8.8', 'Kupffer cells': '16.6', 'Dendritic cells': '0.0', 'Langerhans cells': '-0.120', 'Erythroid cells': '0.015', 'Adipocytes (Subcutaneous)': '0.869', 'Adipocytes (Visceral)': '0.899', 'Breast glandular cells (progenitors)': '-0.372', 'Adipocytes (Breast)': '0.952', 'Colon enterocytes': '0.070', 'Colon enteroendocrine cells': '0.335', 'Enteric glia cells': '0.195', 'Mitotic cells (Colon)': '-0.094', 'Mitotic cells (Heart)': '0.269', 'Podocytes': '-0.235', 'Ascending Loop of Henle cells': '0.585', 'Intercalated cells': '0.070', 'Cholangiocyte': '-0.146', 'NK-cells (Liver)': '0.225', 'Respiratory ciliated cells': '-0.087', 'Mitotic cells (Lung)': '0.087', 'NK-cells (Lung)': '-0.233', 'B-cells (Lung)': '-0.326', 'Alpha cells': '0.236', 'Beta cells': '0.163', 'Prostate glandular cells': '0.803', 'Prostate basal glandular cells': '0.251', 'Urothelial cells': '-0.242', 'Keratinocyte (other)': '-0.629', 'Keratinocyte (granular)': '-0.186', 'Hair cortex cells': '0.356', 'Inner root sheath cells': '0.300', 'Outer root sheath cells': '0.341', 'Sebaceous gland cells': '0.420', 'Eccrine sweat gland cells': '0.611', 'Adipocytes (Skin)': '0.773', 'Mitotic cells (Skin)': '-0.018', 'Parietal cells': '0.022', 'Chief cells': '0.203', 'Gastric mucous cells': '0.146', 'Gastric enteroendocrine cells': '0.199', 'Mitotic cells (Stomach)': '0.248', 'Parafollicular cells': '0.052', 'Thyroid glandular cells': '0.507', 'Mitotic cells (Thyroid)': '-0.178', 'Adrenal cortex cells': '0.459', 'Adrenal medulla cells': '0.078', 'Mitotic cells (Adrenal gland)': '0.204', 'Minor salivary glandular cells': '0.404', 'Minor salivary gland ductal cells': '0.301', 'Minor salivary gland basal cells': '-0.250', 'Mitotic cells (Minor salivary gland)': '-0.319', 'Adipocytes (Minor salivary gland)': '0.292', 'Somatotropes': '-0.462', 'Lactotropes': '-0.381', 'Gonadotropes': '0.021', 'Corticotropes': '-0.046', 'Thyrotropes': '0.076', 'Undifferentiated cells (Pituitary gland)': '0.711', 'Mitotic cells (Spleen)': '-0.035', 'Platelets': '0.231', 'Erythrocytes': '0.145', 'Hematopoietic stem cells': '0.327', 'B-cells (Spleen)': '-0.236', 'NK-cells (Spleen)': '-0.031', 'Amygdala excitatory': '0.0', 'Cerebellar inhibitory': '0.1', 'Cge interneuron': '0.3', 'Deep-layer corticothalamic and 6b': '0.3', 'Deep-layer intratelencephalic': '0.1', 'Deep-layer near-projecting': '0.2', 'Eccentric medium spiny neuron': '0.1', 'Hippocampal ca1-3': '0.1', 'Hippocampal ca4': '0.6', 'Hippocampal dentate gyrus': '0.0', 'Lamp5-lhx6 and chandelier': '0.3', 'Lower rhombic lip': '0.1', 'Mammillary body': '0.1', 'Medium spiny neuron': '0.0', 'Mge interneuron': '0.2', 'Midbrain-derived inhibitory': '0.1', 'Miscellaneous': '0.1', 'Splatter': '0.2', 'Thalamic excitatory': '0.1', 'Upper rhombic lip': '0.1', 'Upper-layer intratelencephalic': '0.3', 'Astrocyte': '0.3', 'Bergmann glia': '0.5', 'Central nervous system macrophage': '0.0', 'Choroid plexus epithelial cell': '0.1', 'Committed oligodendrocyte precursor': '0.1', 'Ependymal cell': '0.1', 'Oligodendrocyte': '0.0', 'Oligodendrocyte precursor cell': '0.3', 'Endothelial cell': '0.1', 'Pericyte': '0.0', 'Vascular associated smooth muscle cell': '0.0', 'Fibroblast': '0.0', 'Leukocyte': '0.0', 'Basophil': '18.1', 'Eosinophil': '13.7', 'Neutrophil': '291.1', 'Classical monocyte': '22.5', 'Non-classical monocyte': '0.7', 'Intermediate monocyte': '11.2', 'T-reg': '1.2', 'GdT-cell': '0.1', 'MAIT T-cell': '1.3', 'Memory CD4 T-cell': '0.0', 'Naive CD4 T-cell': '0.3', 'Memory CD8 T-cell': '0.0', 'Naive CD8 T-cell': '0.3', 'Memory B-cell': '0.3', 'Naive B-cell': '0.5', 'Plasmacytoid DC': '1.1', 'Myeloid DC': '3.2', 'NK-cell': '0.3', 'Total PBMC': '32.5', 'Vd2 gdTCR': '1.1', 'Memory CD4 T-cell TFH': '0.3', 'Memory CD4 T-cell Th2': '0.3', 'Memory CD4 T-cell Th17': '0.2', 'Memory CD4 T-cell Th1\\/Th17': '0.3', 'Non-Vd2 gdTCR': '1.1', 'Memory CD4 T-cell Th1': '0.3', 'Terminal effector memory CD4 T-cell': '1.1', 'Central memory CD8 T-cell': '1.3', 'Effector memory CD8 T-cell': '1.2', 'Terminal effector memory CD8 T-cell': '1.1', 'Switched memory B-cell': '4.9', 'Plasmablast': '2.4', 'Non-switched memory B-cell': '4.9', 'Exhausted memory B-cell': '5.2', 'Progenitor cell': '2.8', 'Naive CD4 T-cell activated': '0.1', 'Naive CD8 T-cell activated': '0.1', 'Memory T-reg': '0.3', 'Naive T-reg': '0.3'}
6FW2
{}
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[42.99, 39.67, 40.95, 41.31, 39.91, 39.59, 41.54, 42.74, 41.74, 41.37, 38.81, 37.86, 39.91, 41.9, 37.73, 38.57, 43.13, 41.19, 53.5, 50.28, 54.41, 52.57, 51.35, 53.58, 59.95, 60.55, 60.63, 63.55, 61.1, 67.74, 66.78, 72.71, 76.88, 75.71, 80.47, 75.44, 76.01, 78.28, 76.01, 71.05, 69.15, 72.06, 67.32, 62.58, 66.19, 64.84, 60.64, 69.1, 64.95, 63.29, 77.89, 87.27, 92.25, 96.92, 97.83, 98.42, 98.8, 98.88, 98.85, 98.84, 98.91, 98.84, 98.77, 98.76, 98.5, 98.74, 98.7, 98.06, 98.59, 98.44, 98.32, 98.39, 98.41, 98.46, 98.47, 98.55, 98.71, 98.73, 98.79, 98.63, 98.0, 98.63, 98.73, 98.79, 98.51, 97.57, 94.92, 95.0, 97.4, 98.25, 98.73, 98.69, 98.46, 98.7, 98.86, 98.83, 98.83, 98.49, 97.67, 97.72, 98.22, 98.56, 98.62, 98.67, 98.13, 97.75, 95.32, 96.3, 97.87, 97.81, 98.16, 98.6, 98.36, 98.42, 98.61, 98.25, 98.24, 97.18, 95.57, 92.42, 88.98, 87.34, 94.87, 97.08, 98.07, 98.18, 98.34, 97.31, 89.93, 90.24, 93.32, 96.59, 98.11, 97.95, 97.05, 94.71, 92.84, 90.09, 91.19, 93.47, 94.44, 95.81, 97.04, 97.88, 98.1, 98.62, 98.63, 98.44, 98.66, 98.52, 98.62, 95.76, 95.57, 97.32, 98.05, 98.69, 98.69, 98.64, 98.59, 98.59, 98.07, 97.57, 97.88, 97.82, 97.75, 98.41, 98.11, 98.48, 98.37, 97.65, 97.5, 97.88, 97.51, 97.16, 96.97, 97.19, 98.25, 98.57, 98.59, 98.72, 98.68, 98.39, 98.43, 97.63, 94.59, 95.81, 98.13, 98.16, 98.39, 98.45, 98.29, 98.39, 97.87, 97.08, 96.19, 95.92, 95.79, 97.62, 98.41, 98.28, 98.12, 98.1, 98.42, 98.48, 98.65, 98.65, 98.79, 98.42, 97.66, 97.64, 98.57, 98.54, 98.88, 98.91, 98.89, 98.91, 98.88, 98.87, 98.83, 98.85, 98.84, 98.79, 98.85, 98.79, 98.7, 98.62, 98.51, 98.16, 96.6, 96.47, 97.93, 98.43, 98.28, 98.44, 97.73, 98.29, 98.62, 98.54, 98.8, 98.89, 98.92, 98.93, 98.91, 98.78, 98.44, 98.48, 98.41, 98.65, 98.61, 98.48, 98.53, 98.37, 97.51, 97.79, 97.67, 97.93, 98.34, 97.98, 98.17, 95.46, 95.33, 98.49, 98.39, 98.68, 98.48, 98.65, 98.48, 98.15, 98.52, 98.52, 97.6, 97.94, 94.92, 96.82, 96.76, 97.8, 97.99, 97.94, 97.09, 95.72, 95.1, 96.21, 96.76, 97.17, 96.84, 95.16, 88.93, 88.15, 97.41, 97.98, 98.01, 97.68, 98.39, 98.52, 97.57, 97.73, 98.12, 98.28, 97.6, 96.9, 96.02, 95.48, 96.16, 95.4, 94.58, 94.29, 93.46, 96.1, 94.61, 95.15, 96.97, 98.29, 98.63, 98.8, 98.74, 98.84, 98.86, 98.84, 98.79, 98.67, 98.09, 97.85, 98.33, 98.28, 98.64, 98.76, 98.82, 98.8, 98.66, 98.56, 98.24, 98.45, 97.97, 96.47, 92.98, 72.8, 54.15]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
91.167418
0.356647
2,230
O60260
Q6NUN9
21376232
Manual_NQ, UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
ZNF746
MAEAVAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGESPKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGGVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKTPARGQPLPTPPAPPDPFKSPASKGPLASTDLVTDWTCGLSVLGPTDGGDM
Homo sapiens
Cytoplasm, Nucleus
Low tissue specificity
{'Ciliated cells': '4.8', 'Basal respiratory cells': '2.5', 'Club cells': '5.2', 'Ionocytes': '4.0', 'Mucus glandular cells': '6.1', 'Serous glandular cells': '6.1', 'Gastric mucus-secreting cells': '9.4', 'Proximal enterocytes': '1.6', 'Paneth cells': '2.8', 'Distal enterocytes': '4.6', 'Intestinal goblet cells': '3.9', 'Exocrine glandular cells': '-0.648', 'Basal prostatic cells': '8.6', 'Prostatic glandular cells': '6.5', 'Breast glandular cells': '0.465', 'Breast myoepithelial cells': '0.241', 'Glandular and luminal cells': '4.1', 'Secretory cells': '5.6', 'Basal keratinocytes': '3.5', 'Suprabasal keratinocytes': '4.0', 'Basal squamous epithelial cells': '5.3', 'Squamous epithelial cells': '4.2', 'Alveolar cells type 1': '-0.026', 'Alveolar cells type 2': '-0.022', 'Salivary duct cells': '5.3', 'Ductal cells': '0.654', 'Hepatocytes': '0.239', 'Cholangiocytes': '3.8', 'Proximal tubular cells': '0.241', 'Distal tubular cells': '0.0', 'Collecting duct cells': '9.7', 'Mesothelial cells': '0.274', 'Sertoli cells': '-0.289', 'Granulosa cells': '4.3', 'Enteroendocrine cells': '2.9', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '-0.353', 'Excitatory neurons': '13.4', 'Inhibitory neurons': '12.3', 'Cone photoreceptor cells': '10.2', 'Rod photoreceptor cells': '8.9', 'Bipolar cells': '16.3', 'Horizontal cells': '16.4', 'Astrocytes': '8.4', 'Oligodendrocyte precursor cells': '5.7', 'Oligodendrocytes': '7.6', 'Microglial cells': '7.2', 'Muller glia cells': '4.4', 'Schwann cells': '0.032', 'Spermatogonia': '0.122', 'Spermatocytes': '0.431', 'Early spermatids': '0.657', 'Late spermatids': '0.407', 'Oocytes': '10.3', 'Cytotrophoblasts': '6.8', 'Syncytiotrophoblasts': '10.3', 'Extravillous trophoblasts': '7.2', 'Endothelial cells': '6.0', 'Lymphatic endothelial cells': '12.9', 'Cardiomyocytes': '0.476', 'Skeletal myocytes': '-0.288', 'Smooth muscle cells': '5.8', 'Adipocytes': '5.6', 'Melanocytes': '0.144', 'Fibroblasts': '7.1', 'Peritubular cells': '-0.275', 'Endometrial stromal cells': '7.6', 'Ovarian stromal cells': '3.2', 'Undifferentiated cells': '4.3', 'T-cells': '7.6', 'B-cells': '5.8', 'Plasma cells': '4.9', 'Nk-cells': '9.2', 'Granulocytes': '8.3', 'Monocytes': '9.1', 'Macrophages': '9.0', 'Hofbauer cells': '8.0', 'Kupffer cells': '16.2', 'Dendritic cells': '10.3', 'Langerhans cells': '0.145', 'Erythroid cells': '-0.015', 'Adipocytes (Subcutaneous)': '0.170', 'Adipocytes (Visceral)': '-0.094', 'Breast glandular cells (progenitors)': '0.350', 'Adipocytes (Breast)': '-0.236', 'Colon enterocytes': '-0.110', 'Colon enteroendocrine cells': '0.229', 'Enteric glia cells': '0.097', 'Mitotic cells (Colon)': '-0.103', 'Mitotic cells (Heart)': '0.491', 'Podocytes': '-0.260', 'Ascending Loop of Henle cells': '0.329', 'Intercalated cells': '-0.211', 'Cholangiocyte': '0.293', 'NK-cells (Liver)': '-0.188', 'Respiratory ciliated cells': '-0.069', 'Mitotic cells (Lung)': '0.041', 'NK-cells (Lung)': '-0.040', 'B-cells (Lung)': '-0.144', 'Alpha cells': '0.471', 'Beta cells': '0.343', 'Prostate glandular cells': '-0.014', 'Prostate basal glandular cells': '0.352', 'Urothelial cells': '0.233', 'Keratinocyte (other)': '0.156', 'Keratinocyte (granular)': '0.068', 'Hair cortex cells': '0.042', 'Inner root sheath cells': '0.107', 'Outer root sheath cells': '0.067', 'Sebaceous gland cells': '-0.020', 'Eccrine sweat gland cells': '-0.120', 'Adipocytes (Skin)': '-0.086', 'Mitotic cells (Skin)': '0.163', 'Parietal cells': '-0.651', 'Chief cells': '-0.567', 'Gastric mucous cells': '-0.388', 'Gastric enteroendocrine cells': '-0.389', 'Mitotic cells (Stomach)': '0.040', 'Parafollicular cells': '-0.003', 'Thyroid glandular cells': '0.344', 'Mitotic cells (Thyroid)': '-0.032', 'Adrenal cortex cells': '0.280', 'Adrenal medulla cells': '-0.034', 'Mitotic cells (Adrenal gland)': '0.150', 'Minor salivary glandular cells': '0.606', 'Minor salivary gland ductal cells': '0.226', 'Minor salivary gland basal cells': '0.202', 'Mitotic cells (Minor salivary gland)': '0.246', 'Adipocytes (Minor salivary gland)': '0.172', 'Somatotropes': '0.239', 'Lactotropes': '0.102', 'Gonadotropes': '0.033', 'Corticotropes': '0.090', 'Thyrotropes': '0.098', 'Undifferentiated cells (Pituitary gland)': '-0.058', 'Mitotic cells (Spleen)': '-0.290', 'Platelets': '0.282', 'Erythrocytes': '-0.070', 'Hematopoietic stem cells': '0.010', 'B-cells (Spleen)': '0.143', 'NK-cells (Spleen)': '0.222', 'Amygdala excitatory': '22.4', 'Cerebellar inhibitory': '13.4', 'Cge interneuron': '16.5', 'Deep-layer corticothalamic and 6b': '19.0', 'Deep-layer intratelencephalic': '22.4', 'Deep-layer near-projecting': '20.6', 'Eccentric medium spiny neuron': '18.1', 'Hippocampal ca1-3': '26.2', 'Hippocampal ca4': '28.0', 'Hippocampal dentate gyrus': '30.9', 'Lamp5-lhx6 and chandelier': '19.0', 'Lower rhombic lip': '23.9', 'Mammillary body': '29.5', 'Medium spiny neuron': '20.5', 'Mge interneuron': '24.9', 'Midbrain-derived inhibitory': '21.1', 'Miscellaneous': '20.2', 'Splatter': '20.5', 'Thalamic excitatory': '18.0', 'Upper rhombic lip': '17.7', 'Upper-layer intratelencephalic': '20.9', 'Astrocyte': '12.5', 'Bergmann glia': '11.7', 'Central nervous system macrophage': '25.9', 'Choroid plexus epithelial cell': '14.5', 'Committed oligodendrocyte precursor': '13.0', 'Ependymal cell': '13.1', 'Oligodendrocyte': '12.4', 'Oligodendrocyte precursor cell': '15.7', 'Endothelial cell': '16.2', 'Pericyte': '15.1', 'Vascular associated smooth muscle cell': '12.9', 'Fibroblast': '16.1', 'Leukocyte': '19.4', 'Basophil': '12.3', 'Eosinophil': '0.8', 'Neutrophil': '40.8', 'Classical monocyte': '21.1', 'Non-classical monocyte': '18.1', 'Intermediate monocyte': '5.4', 'T-reg': '4.1', 'GdT-cell': '0.4', 'MAIT T-cell': '5.7', 'Memory CD4 T-cell': '0.6', 'Naive CD4 T-cell': '12.4', 'Memory CD8 T-cell': '1.0', 'Naive CD8 T-cell': '13.8', 'Memory B-cell': '0.2', 'Naive B-cell': '16.9', 'Plasmacytoid DC': '5.0', 'Myeloid DC': '5.9', 'NK-cell': '19.8', 'Total PBMC': '4.5', 'Vd2 gdTCR': '6.4', 'Memory CD4 T-cell Th1\\/Th17': '14.4', 'Memory CD4 T-cell Th17': '15.1', 'Memory CD4 T-cell Th2': '17.3', 'Non-Vd2 gdTCR': '7.3', 'Memory CD4 T-cell Th1': '17.2', 'Memory CD4 T-cell TFH': '19.9', 'Terminal effector memory CD4 T-cell': '5.1', 'Central memory CD8 T-cell': '5.0', 'Effector memory CD8 T-cell': '5.7', 'Terminal effector memory CD8 T-cell': '6.8', 'Non-switched memory B-cell': '4.1', 'Plasmablast': '2.9', 'Switched memory B-cell': '5.1', 'Exhausted memory B-cell': '6.1', 'Progenitor cell': '4.4', 'Memory T-reg': '20.2', 'Naive CD4 T-cell activated': '18.4', 'Naive CD8 T-cell activated': '16.0', 'Naive T-reg': '17.1'}
null
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
51.634348
0.724208
1,140
O60260
Q70CQ3
22199232, UNIPROT
UbiNet, UbiBrowser, 31181401
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
USP30
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
Homo sapiens
Mitochondrion outer membrane
Low tissue specificity
{'Ciliated cells': '4.5', 'Basal respiratory cells': '4.1', 'Club cells': '5.1', 'Ionocytes': '3.3', 'Mucus glandular cells': '2.9', 'Serous glandular cells': '6.5', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '9.6', 'Paneth cells': '9.2', 'Distal enterocytes': '11.1', 'Intestinal goblet cells': '8.5', 'Exocrine glandular cells': '-0.389', 'Basal prostatic cells': '3.4', 'Prostatic glandular cells': '6.9', 'Breast glandular cells': '0.490', 'Breast myoepithelial cells': '0.468', 'Glandular and luminal cells': '3.5', 'Secretory cells': '3.9', 'Basal keratinocytes': '2.3', 'Suprabasal keratinocytes': '4.0', 'Basal squamous epithelial cells': '6.0', 'Squamous epithelial cells': '4.5', 'Alveolar cells type 1': '0.251', 'Alveolar cells type 2': '0.041', 'Salivary duct cells': '4.1', 'Ductal cells': '0.285', 'Hepatocytes': '0.676', 'Cholangiocytes': '7.6', 'Proximal tubular cells': '0.245', 'Distal tubular cells': '0.0', 'Collecting duct cells': '3.9', 'Mesothelial cells': '0.306', 'Sertoli cells': '-0.250', 'Granulosa cells': '6.6', 'Enteroendocrine cells': '6.0', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '-0.341', 'Excitatory neurons': '18.2', 'Inhibitory neurons': '21.8', 'Cone photoreceptor cells': '11.9', 'Rod photoreceptor cells': '12.7', 'Bipolar cells': '5.5', 'Horizontal cells': '5.7', 'Astrocytes': '10.2', 'Oligodendrocyte precursor cells': '15.6', 'Oligodendrocytes': '38.9', 'Microglial cells': '7.2', 'Muller glia cells': '5.4', 'Schwann cells': '0.092', 'Spermatogonia': '0.019', 'Spermatocytes': '0.373', 'Early spermatids': '0.659', 'Late spermatids': '0.421', 'Oocytes': '12.5', 'Cytotrophoblasts': '5.9', 'Syncytiotrophoblasts': '6.7', 'Extravillous trophoblasts': '4.3', 'Endothelial cells': '3.6', 'Lymphatic endothelial cells': '4.8', 'Cardiomyocytes': '0.685', 'Skeletal myocytes': '-0.066', 'Smooth muscle cells': '3.5', 'Adipocytes': '4.0', 'Melanocytes': '0.164', 'Fibroblasts': '4.3', 'Peritubular cells': '-0.199', 'Endometrial stromal cells': '4.0', 'Ovarian stromal cells': '4.6', 'Undifferentiated cells': '9.0', 'T-cells': '3.0', 'B-cells': '2.6', 'Plasma cells': '5.1', 'Nk-cells': '3.3', 'Granulocytes': '3.3', 'Monocytes': '2.8', 'Macrophages': '2.8', 'Hofbauer cells': '6.3', 'Kupffer cells': '2.3', 'Dendritic cells': '3.4', 'Langerhans cells': '0.302', 'Erythroid cells': '0.047', 'Adipocytes (Subcutaneous)': '0.395', 'Adipocytes (Visceral)': '0.202', 'Breast glandular cells (progenitors)': '0.346', 'Adipocytes (Breast)': '-0.258', 'Colon enterocytes': '0.062', 'Colon enteroendocrine cells': '0.124', 'Enteric glia cells': '-0.058', 'Mitotic cells (Colon)': '0.043', 'Mitotic cells (Heart)': '0.456', 'Podocytes': '-0.108', 'Ascending Loop of Henle cells': '0.510', 'Intercalated cells': '0.029', 'Cholangiocyte': '-0.135', 'NK-cells (Liver)': '0.169', 'Respiratory ciliated cells': '0.127', 'Mitotic cells (Lung)': '0.003', 'NK-cells (Lung)': '0.125', 'B-cells (Lung)': '0.024', 'Alpha cells': '0.391', 'Beta cells': '0.306', 'Prostate glandular cells': '0.001', 'Prostate basal glandular cells': '0.255', 'Urothelial cells': '0.168', 'Keratinocyte (other)': '0.449', 'Keratinocyte (granular)': '0.232', 'Hair cortex cells': '-0.362', 'Inner root sheath cells': '-0.259', 'Outer root sheath cells': '-0.210', 'Sebaceous gland cells': '-0.071', 'Eccrine sweat gland cells': '-0.249', 'Adipocytes (Skin)': '-0.293', 'Mitotic cells (Skin)': '0.133', 'Parietal cells': '-0.401', 'Chief cells': '-0.382', 'Gastric mucous cells': '-0.335', 'Gastric enteroendocrine cells': '-0.272', 'Mitotic cells (Stomach)': '-0.051', 'Parafollicular cells': '0.068', 'Thyroid glandular cells': '0.396', 'Mitotic cells (Thyroid)': '-0.086', 'Adrenal cortex cells': '0.631', 'Adrenal medulla cells': '-0.004', 'Mitotic cells (Adrenal gland)': '0.403', 'Minor salivary glandular cells': '0.492', 'Minor salivary gland ductal cells': '0.321', 'Minor salivary gland basal cells': '0.105', 'Mitotic cells (Minor salivary gland)': '0.086', 'Adipocytes (Minor salivary gland)': '0.055', 'Somatotropes': '-0.067', 'Lactotropes': '-0.039', 'Gonadotropes': '0.068', 'Corticotropes': '0.033', 'Thyrotropes': '0.169', 'Undifferentiated cells (Pituitary gland)': '0.219', 'Mitotic cells (Spleen)': '-0.332', 'Platelets': '-0.217', 'Erythrocytes': '-0.182', 'Hematopoietic stem cells': '-0.266', 'B-cells (Spleen)': '0.315', 'NK-cells (Spleen)': '0.318', 'Amygdala excitatory': '27.8', 'Cerebellar inhibitory': '27.9', 'Cge interneuron': '30.6', 'Deep-layer corticothalamic and 6b': '26.1', 'Deep-layer intratelencephalic': '25.7', 'Deep-layer near-projecting': '34.1', 'Eccentric medium spiny neuron': '24.7', 'Hippocampal ca1-3': '28.2', 'Hippocampal ca4': '21.1', 'Hippocampal dentate gyrus': '25.0', 'Lamp5-lhx6 and chandelier': '32.9', 'Lower rhombic lip': '25.9', 'Mammillary body': '35.4', 'Medium spiny neuron': '23.6', 'Mge interneuron': '34.5', 'Midbrain-derived inhibitory': '24.9', 'Miscellaneous': '30.2', 'Splatter': '29.0', 'Thalamic excitatory': '28.3', 'Upper rhombic lip': '24.7', 'Upper-layer intratelencephalic': '28.9', 'Astrocyte': '28.4', 'Bergmann glia': '20.0', 'Central nervous system macrophage': '18.7', 'Choroid plexus epithelial cell': '27.2', 'Committed oligodendrocyte precursor': '31.5', 'Ependymal cell': '24.5', 'Oligodendrocyte': '70.0', 'Oligodendrocyte precursor cell': '29.7', 'Endothelial cell': '17.1', 'Pericyte': '16.6', 'Vascular associated smooth muscle cell': '14.1', 'Fibroblast': '20.8', 'Leukocyte': '10.5', 'Basophil': '26.9', 'Eosinophil': '16.2', 'Neutrophil': '16.6', 'Classical monocyte': '10.7', 'Non-classical monocyte': '13.6', 'Intermediate monocyte': '23.3', 'T-reg': '24.4', 'GdT-cell': '17.5', 'MAIT T-cell': '30.1', 'Memory CD4 T-cell': '14.8', 'Naive CD4 T-cell': '21.9', 'Memory CD8 T-cell': '16.8', 'Naive CD8 T-cell': '18.4', 'Memory B-cell': '17.4', 'Naive B-cell': '20.2', 'Plasmacytoid DC': '13.0', 'Myeloid DC': '12.4', 'NK-cell': '23.0', 'Total PBMC': '18.2', 'Vd2 gdTCR': '21.8', 'Memory CD4 T-cell TFH': '17.4', 'Memory CD4 T-cell Th2': '19.1', 'Memory CD4 T-cell Th17': '20.3', 'Memory CD4 T-cell Th1\\/Th17': '19.9', 'Non-Vd2 gdTCR': '21.9', 'Memory CD4 T-cell Th1': '17.2', 'Terminal effector memory CD4 T-cell': '29.4', 'Central memory CD8 T-cell': '16.6', 'Effector memory CD8 T-cell': '23.3', 'Terminal effector memory CD8 T-cell': '26.1', 'Switched memory B-cell': '18.2', 'Plasmablast': '21.3', 'Non-switched memory B-cell': '22.8', 'Exhausted memory B-cell': '17.1', 'Progenitor cell': '29.5', 'Naive CD4 T-cell activated': '5.9', 'Naive CD8 T-cell activated': '7.4', 'Memory T-reg': '18.0', 'Naive T-reg': '20.5'}
5OHK, 5OHN, 5OHP, 8D0A, 8D1T
{'Adipose Tissue': 10.91080149501661, 'Adrenal Gland': 12.979922480620155, 'Bladder': 10.17204761904762, 'Blood': 2.829852055974166, 'Blood Vessel': 10.647262921348316, 'Brain': 10.672734897804691, 'Breast': 11.882705882352942, 'Cervix Uteri': 16.144578947368423, 'Colon': 9.684649550706032, 'Esophagus': 7.476896885813149, 'Fallopian Tube': 12.43688888888889, 'Heart': 4.001723228803717, 'Kidney': 5.353741573033708, 'Liver': 8.10839203539823, 'Lung': 9.759517301038064, 'Muscle': 6.521188044831881, 'Nerve': 13.907550888529888, 'Ovary': 16.581872222222223, 'Pancreas': 4.817064024390244, 'Pituitary': 18.24446996466431, 'Prostate': 10.181991836734694, 'Salivary Gland': 8.41788888888889, 'Skin': 12.67955444997236, 'Small Intestine': 9.92027807486631, 'Spleen': 7.129854771784233, 'Stomach': 6.718114206128133, 'Testis': 22.115318559556787, 'Thyroid': 11.513070444104134, 'Uterus': 15.13730985915493, 'Vagina': 11.445365384615386}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
76.599807
0.485938
1,520
O60260
Q86VP1
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
TAX1BP1
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD
Homo sapiens
Cytoplasm, Mitochondrion, Preautophagosomal structure, Cytoplasmic vesicle, autophagosome
Low tissue specificity
{'Ciliated cells': '351.9', 'Basal respiratory cells': '226.9', 'Club cells': '240.2', 'Ionocytes': '230.5', 'Mucus glandular cells': '255.9', 'Serous glandular cells': '222.7', 'Gastric mucus-secreting cells': '117.3', 'Proximal enterocytes': '137.4', 'Paneth cells': '138.6', 'Distal enterocytes': '165.2', 'Intestinal goblet cells': '147.1', 'Exocrine glandular cells': '-0.587', 'Basal prostatic cells': '175.9', 'Prostatic glandular cells': '175.6', 'Breast glandular cells': '0.518', 'Breast myoepithelial cells': '0.382', 'Glandular and luminal cells': '253.4', 'Secretory cells': '140.1', 'Basal keratinocytes': '181.0', 'Suprabasal keratinocytes': '259.3', 'Basal squamous epithelial cells': '93.3', 'Squamous epithelial cells': '126.8', 'Alveolar cells type 1': '0.337', 'Alveolar cells type 2': '0.261', 'Salivary duct cells': '231.2', 'Ductal cells': '0.564', 'Hepatocytes': '0.553', 'Cholangiocytes': '143.1', 'Proximal tubular cells': '0.328', 'Distal tubular cells': '399.5', 'Collecting duct cells': '130.3', 'Mesothelial cells': '0.248', 'Sertoli cells': '0.553', 'Granulosa cells': '125.9', 'Enteroendocrine cells': '122.0', 'Pancreatic endocrine cells': '140.9', 'Leydig cells': '0.523', 'Excitatory neurons': '103.8', 'Inhibitory neurons': '102.6', 'Cone photoreceptor cells': '149.5', 'Rod photoreceptor cells': '121.2', 'Bipolar cells': '302.5', 'Horizontal cells': '111.4', 'Astrocytes': '55.1', 'Oligodendrocyte precursor cells': '76.9', 'Oligodendrocytes': '98.4', 'Microglial cells': '82.3', 'Muller glia cells': '170.2', 'Schwann cells': '0.038', 'Spermatogonia': '0.668', 'Spermatocytes': '0.560', 'Early spermatids': '-0.138', 'Late spermatids': '-0.488', 'Oocytes': '334.5', 'Cytotrophoblasts': '152.6', 'Syncytiotrophoblasts': '794.8', 'Extravillous trophoblasts': '121.8', 'Endothelial cells': '133.5', 'Lymphatic endothelial cells': '112.0', 'Cardiomyocytes': '0.701', 'Skeletal myocytes': '-0.320', 'Smooth muscle cells': '151.6', 'Adipocytes': '114.9', 'Melanocytes': '0.104', 'Fibroblasts': '136.1', 'Peritubular cells': '0.331', 'Endometrial stromal cells': '129.0', 'Ovarian stromal cells': '139.6', 'Undifferentiated cells': '98.0', 'T-cells': '172.9', 'B-cells': '120.4', 'Plasma cells': '138.3', 'Nk-cells': '204.2', 'Granulocytes': '136.5', 'Monocytes': '369.0', 'Macrophages': '184.4', 'Hofbauer cells': '139.5', 'Kupffer cells': '132.5', 'Dendritic cells': '204.5', 'Langerhans cells': '0.223', 'Erythroid cells': '-0.057', 'Adipocytes (Subcutaneous)': '-0.013', 'Adipocytes (Visceral)': '-0.105', 'Breast glandular cells (progenitors)': '0.317', 'Adipocytes (Breast)': '-0.362', 'Colon enterocytes': '-0.119', 'Colon enteroendocrine cells': '0.266', 'Enteric glia cells': '-0.281', 'Mitotic cells (Colon)': '-0.111', 'Mitotic cells (Heart)': '0.442', 'Podocytes': '0.113', 'Ascending Loop of Henle cells': '0.334', 'Intercalated cells': '0.101', 'Cholangiocyte': '0.394', 'NK-cells (Liver)': '-0.390', 'Respiratory ciliated cells': '0.154', 'Mitotic cells (Lung)': '0.057', 'NK-cells (Lung)': '-0.031', 'B-cells (Lung)': '-0.185', 'Alpha cells': '0.343', 'Beta cells': '0.146', 'Prostate glandular cells': '-0.040', 'Prostate basal glandular cells': '0.084', 'Urothelial cells': '-0.027', 'Keratinocyte (other)': '0.161', 'Keratinocyte (granular)': '0.010', 'Hair cortex cells': '-0.044', 'Inner root sheath cells': '0.040', 'Outer root sheath cells': '0.145', 'Sebaceous gland cells': '0.045', 'Eccrine sweat gland cells': '0.071', 'Adipocytes (Skin)': '-0.075', 'Mitotic cells (Skin)': '0.223', 'Parietal cells': '-0.387', 'Chief cells': '-0.385', 'Gastric mucous cells': '-0.243', 'Gastric enteroendocrine cells': '-0.354', 'Mitotic cells (Stomach)': '0.062', 'Parafollicular cells': '0.150', 'Thyroid glandular cells': '0.574', 'Mitotic cells (Thyroid)': '-0.063', 'Adrenal cortex cells': '0.768', 'Adrenal medulla cells': '0.025', 'Mitotic cells (Adrenal gland)': '0.506', 'Minor salivary glandular cells': '0.395', 'Minor salivary gland ductal cells': '-0.114', 'Minor salivary gland basal cells': '0.619', 'Mitotic cells (Minor salivary gland)': '0.633', 'Adipocytes (Minor salivary gland)': '0.211', 'Somatotropes': '0.141', 'Lactotropes': '0.079', 'Gonadotropes': '0.049', 'Corticotropes': '-0.008', 'Thyrotropes': '0.222', 'Undifferentiated cells (Pituitary gland)': '0.093', 'Mitotic cells (Spleen)': '-0.104', 'Platelets': '0.113', 'Erythrocytes': '-0.168', 'Hematopoietic stem cells': '0.037', 'B-cells (Spleen)': '0.054', 'NK-cells (Spleen)': '0.185', 'Amygdala excitatory': '127.0', 'Cerebellar inhibitory': '189.0', 'Cge interneuron': '145.9', 'Deep-layer corticothalamic and 6b': '143.9', 'Deep-layer intratelencephalic': '140.9', 'Deep-layer near-projecting': '118.2', 'Eccentric medium spiny neuron': '169.2', 'Hippocampal ca1-3': '151.3', 'Hippocampal ca4': '153.7', 'Hippocampal dentate gyrus': '125.4', 'Lamp5-lhx6 and chandelier': '144.6', 'Lower rhombic lip': '180.1', 'Mammillary body': '209.6', 'Medium spiny neuron': '139.8', 'Mge interneuron': '165.3', 'Midbrain-derived inhibitory': '220.6', 'Miscellaneous': '121.8', 'Splatter': '152.8', 'Thalamic excitatory': '187.2', 'Upper rhombic lip': '148.8', 'Upper-layer intratelencephalic': '143.2', 'Astrocyte': '121.0', 'Bergmann glia': '123.9', 'Central nervous system macrophage': '223.6', 'Choroid plexus epithelial cell': '203.2', 'Committed oligodendrocyte precursor': '143.3', 'Ependymal cell': '203.4', 'Oligodendrocyte': '160.8', 'Oligodendrocyte precursor cell': '153.9', 'Endothelial cell': '242.9', 'Pericyte': '183.1', 'Vascular associated smooth muscle cell': '184.0', 'Fibroblast': '170.2', 'Leukocyte': '239.4', 'Basophil': '244.9', 'Eosinophil': '213.3', 'Neutrophil': '404.5', 'Classical monocyte': '66.3', 'Non-classical monocyte': '99.9', 'Intermediate monocyte': '239.3', 'T-reg': '188.0', 'GdT-cell': '68.7', 'MAIT T-cell': '172.0', 'Memory CD4 T-cell': '82.1', 'Naive CD4 T-cell': '79.6', 'Memory CD8 T-cell': '80.6', 'Naive CD8 T-cell': '61.9', 'Memory B-cell': '71.2', 'Naive B-cell': '53.7', 'Plasmacytoid DC': '161.7', 'Myeloid DC': '153.7', 'NK-cell': '70.7', 'Total PBMC': '187.5', 'Vd2 gdTCR': '178.5', 'Memory CD4 T-cell Th1\\/Th17': '80.6', 'Memory CD4 T-cell Th17': '78.6', 'Memory CD4 T-cell Th2': '81.4', 'Non-Vd2 gdTCR': '204.4', 'Memory CD4 T-cell Th1': '69.2', 'Memory CD4 T-cell TFH': '68.1', 'Terminal effector memory CD4 T-cell': '187.3', 'Central memory CD8 T-cell': '175.1', 'Effector memory CD8 T-cell': '218.4', 'Terminal effector memory CD8 T-cell': '187.5', 'Non-switched memory B-cell': '143.3', 'Plasmablast': '191.8', 'Switched memory B-cell': '150.1', 'Exhausted memory B-cell': '133.4', 'Progenitor cell': '122.1', 'Memory T-reg': '72.8', 'Naive CD4 T-cell activated': '60.6', 'Naive CD8 T-cell activated': '64.0', 'Naive T-reg': '75.9'}
2M7Q, 4BMJ, 4NLH, 4Z4K, 4Z4M, 5AAS, 5YT6, 5Z7G
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
75.633194
0.61057
820
O60260
Q8IVP5
23503661
DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
FUNDC1
MATRNPPPQDYESDDDSYEVLDLTEYARRHQWWNRVFGHSSGPMVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQIASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNIVISSGFVGGFLLGLAS
Homo sapiens
Mitochondrion outer membrane
Low tissue specificity
{'Ciliated cells': '23.5', 'Basal respiratory cells': '67.0', 'Club cells': '31.7', 'Ionocytes': '44.2', 'Mucus glandular cells': '17.4', 'Serous glandular cells': '38.1', 'Gastric mucus-secreting cells': '15.9', 'Proximal enterocytes': '15.1', 'Paneth cells': '21.2', 'Distal enterocytes': '16.0', 'Intestinal goblet cells': '12.1', 'Exocrine glandular cells': '-0.595', 'Basal prostatic cells': '16.1', 'Prostatic glandular cells': '18.1', 'Breast glandular cells': '0.609', 'Breast myoepithelial cells': '0.593', 'Glandular and luminal cells': '23.3', 'Secretory cells': '26.9', 'Basal keratinocytes': '17.9', 'Suprabasal keratinocytes': '23.3', 'Basal squamous epithelial cells': '18.0', 'Squamous epithelial cells': '19.9', 'Alveolar cells type 1': '-0.013', 'Alveolar cells type 2': '0.113', 'Salivary duct cells': '21.0', 'Ductal cells': '0.575', 'Hepatocytes': '0.409', 'Cholangiocytes': '17.2', 'Proximal tubular cells': '0.093', 'Distal tubular cells': '76.8', 'Collecting duct cells': '25.3', 'Mesothelial cells': '0.420', 'Sertoli cells': '0.746', 'Granulosa cells': '54.3', 'Enteroendocrine cells': '19.5', 'Pancreatic endocrine cells': '28.9', 'Leydig cells': '0.662', 'Excitatory neurons': '5.1', 'Inhibitory neurons': '6.2', 'Cone photoreceptor cells': '17.0', 'Rod photoreceptor cells': '10.2', 'Bipolar cells': '23.6', 'Horizontal cells': '12.6', 'Astrocytes': '5.0', 'Oligodendrocyte precursor cells': '6.1', 'Oligodendrocytes': '6.4', 'Microglial cells': '6.3', 'Muller glia cells': '60.0', 'Schwann cells': '0.194', 'Spermatogonia': '0.606', 'Spermatocytes': '0.191', 'Early spermatids': '-0.437', 'Late spermatids': '-0.671', 'Oocytes': '88.2', 'Cytotrophoblasts': '36.8', 'Syncytiotrophoblasts': '23.5', 'Extravillous trophoblasts': '31.0', 'Endothelial cells': '15.3', 'Lymphatic endothelial cells': '13.8', 'Cardiomyocytes': '0.808', 'Skeletal myocytes': '0.418', 'Smooth muscle cells': '17.2', 'Adipocytes': '14.2', 'Melanocytes': '0.255', 'Fibroblasts': '19.6', 'Peritubular cells': '0.484', 'Endometrial stromal cells': '19.6', 'Ovarian stromal cells': '35.7', 'Undifferentiated cells': '21.5', 'T-cells': '11.9', 'B-cells': '12.2', 'Plasma cells': '12.6', 'Nk-cells': '10.9', 'Granulocytes': '15.3', 'Monocytes': '2.4', 'Macrophages': '13.2', 'Hofbauer cells': '33.4', 'Kupffer cells': '8.9', 'Dendritic cells': '16.5', 'Langerhans cells': '0.373', 'Erythroid cells': '0.115', 'Adipocytes (Subcutaneous)': '-0.204', 'Adipocytes (Visceral)': '-0.237', 'Breast glandular cells (progenitors)': '0.410', 'Adipocytes (Breast)': '-0.579', 'Colon enterocytes': '-0.183', 'Colon enteroendocrine cells': '0.443', 'Enteric glia cells': '0.395', 'Mitotic cells (Colon)': '-0.095', 'Mitotic cells (Heart)': '0.403', 'Podocytes': '0.042', 'Ascending Loop of Henle cells': '0.539', 'Intercalated cells': '0.156', 'Cholangiocyte': '0.370', 'NK-cells (Liver)': '-0.192', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '0.258', 'NK-cells (Lung)': '-0.169', 'B-cells (Lung)': '-0.220', 'Alpha cells': '0.460', 'Beta cells': '0.280', 'Prostate glandular cells': '0.201', 'Prostate basal glandular cells': '0.319', 'Urothelial cells': '0.229', 'Keratinocyte (other)': '0.420', 'Keratinocyte (granular)': '-0.167', 'Hair cortex cells': '-0.082', 'Inner root sheath cells': '0.017', 'Outer root sheath cells': '0.238', 'Sebaceous gland cells': '0.007', 'Eccrine sweat gland cells': '-0.018', 'Adipocytes (Skin)': '-0.293', 'Mitotic cells (Skin)': '0.496', 'Parietal cells': '0.513', 'Chief cells': '0.404', 'Gastric mucous cells': '0.632', 'Gastric enteroendocrine cells': '0.489', 'Mitotic cells (Stomach)': '0.471', 'Parafollicular cells': '0.107', 'Thyroid glandular cells': '0.591', 'Mitotic cells (Thyroid)': '-0.029', 'Adrenal cortex cells': '0.593', 'Adrenal medulla cells': '0.154', 'Mitotic cells (Adrenal gland)': '0.411', 'Minor salivary glandular cells': '0.452', 'Minor salivary gland ductal cells': '0.282', 'Minor salivary gland basal cells': '0.178', 'Mitotic cells (Minor salivary gland)': '0.254', 'Adipocytes (Minor salivary gland)': '0.116', 'Somatotropes': '0.091', 'Lactotropes': '0.238', 'Gonadotropes': '0.096', 'Corticotropes': '0.113', 'Thyrotropes': '0.417', 'Undifferentiated cells (Pituitary gland)': '0.094', 'Mitotic cells (Spleen)': '-0.177', 'Platelets': '-0.147', 'Erythrocytes': '-0.124', 'Hematopoietic stem cells': '-0.158', 'B-cells (Spleen)': '0.148', 'NK-cells (Spleen)': '0.218', 'Amygdala excitatory': '8.0', 'Cerebellar inhibitory': '16.7', 'Cge interneuron': '13.2', 'Deep-layer corticothalamic and 6b': '7.5', 'Deep-layer intratelencephalic': '8.2', 'Deep-layer near-projecting': '11.2', 'Eccentric medium spiny neuron': '9.9', 'Hippocampal ca1-3': '8.2', 'Hippocampal ca4': '13.3', 'Hippocampal dentate gyrus': '7.6', 'Lamp5-lhx6 and chandelier': '11.8', 'Lower rhombic lip': '25.1', 'Mammillary body': '13.2', 'Medium spiny neuron': '9.4', 'Mge interneuron': '9.6', 'Midbrain-derived inhibitory': '13.3', 'Miscellaneous': '9.5', 'Splatter': '15.2', 'Thalamic excitatory': '17.3', 'Upper rhombic lip': '13.1', 'Upper-layer intratelencephalic': '6.9', 'Astrocyte': '7.4', 'Bergmann glia': '13.6', 'Central nervous system macrophage': '8.7', 'Choroid plexus epithelial cell': '12.7', 'Committed oligodendrocyte precursor': '8.1', 'Ependymal cell': '8.6', 'Oligodendrocyte': '8.5', 'Oligodendrocyte precursor cell': '8.1', 'Endothelial cell': '6.5', 'Pericyte': '8.9', 'Vascular associated smooth muscle cell': '7.9', 'Fibroblast': '7.0', 'Leukocyte': '5.8', 'Basophil': '12.6', 'Eosinophil': '10.9', 'Neutrophil': '17.6', 'Classical monocyte': '7.5', 'Non-classical monocyte': '6.0', 'Intermediate monocyte': '9.9', 'T-reg': '19.7', 'GdT-cell': '7.3', 'MAIT T-cell': '20.3', 'Memory CD4 T-cell': '10.1', 'Naive CD4 T-cell': '19.2', 'Memory CD8 T-cell': '11.5', 'Naive CD8 T-cell': '18.2', 'Memory B-cell': '10.9', 'Naive B-cell': '16.2', 'Plasmacytoid DC': '35.0', 'Myeloid DC': '20.5', 'NK-cell': '18.7', 'Total PBMC': '23.2', 'Vd2 gdTCR': '21.7', 'Memory CD4 T-cell Th1\\/Th17': '16.9', 'Memory CD4 T-cell Th17': '17.5', 'Memory CD4 T-cell Th2': '17.3', 'Non-Vd2 gdTCR': '16.7', 'Memory CD4 T-cell Th1': '15.0', 'Memory CD4 T-cell TFH': '15.2', 'Terminal effector memory CD4 T-cell': '17.8', 'Central memory CD8 T-cell': '23.1', 'Effector memory CD8 T-cell': '19.0', 'Terminal effector memory CD8 T-cell': '16.0', 'Non-switched memory B-cell': '19.8', 'Plasmablast': '20.2', 'Switched memory B-cell': '18.9', 'Exhausted memory B-cell': '15.4', 'Progenitor cell': '16.1', 'Memory T-reg': '17.4', 'Naive CD4 T-cell activated': '12.1', 'Naive CD8 T-cell activated': '16.4', 'Naive T-reg': '18.4'}
2N9X, 5GMV
{'Adipose Tissue': 14.10067607973422, 'Adrenal Gland': 18.48981782945736, 'Bladder': 17.278238095238095, 'Blood': 7.770636813778256, 'Blood Vessel': 17.33516404494382, 'Brain': 29.034774413323237, 'Breast': 16.99627015250545, 'Cervix Uteri': 20.63105263157895, 'Colon': 12.506201540436455, 'Esophagus': 14.936246366782006, 'Fallopian Tube': 17.61777777777778, 'Heart': 15.146323925667827, 'Kidney': 14.713134831460676, 'Liver': 4.944515486725663, 'Lung': 13.376956747404844, 'Muscle': 7.882627646326276, 'Nerve': 20.867269789983844, 'Ovary': 24.89922222222222, 'Pancreas': 5.183881097560976, 'Pituitary': 32.159081272084805, 'Prostate': 18.93758775510204, 'Salivary Gland': 19.107296296296298, 'Skin': 19.641403537866225, 'Small Intestine': 11.71457219251337, 'Spleen': 15.064804979253111, 'Stomach': 20.299387186629524, 'Testis': 22.473795013850417, 'Thyroid': 21.62028330781011, 'Uterus': 21.43198591549296, 'Vagina': 22.921237179487186}
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[43.09, 41.9, 42.28, 42.87, 40.13, 55.14, 51.62, 53.28, 40.22, 33.4, 39.78, 33.63, 38.36, 42.12, 42.05, 45.54, 42.21, 43.85, 48.32, 51.38, 51.21, 54.5, 58.66, 60.48, 60.97, 59.48, 60.13, 60.73, 62.17, 56.98, 62.43, 71.33, 61.94, 64.98, 64.81, 60.43, 61.57, 55.83, 55.43, 53.69, 46.75, 45.87, 48.2, 46.48, 51.12, 51.84, 47.01, 50.39, 62.4, 65.87, 71.93, 75.7, 73.47, 79.0, 83.38, 82.3, 84.09, 90.33, 90.71, 90.33, 90.6, 91.99, 91.18, 91.74, 91.84, 90.9, 91.36, 90.59, 87.27, 85.67, 88.05, 89.05, 88.26, 90.94, 93.53, 91.5, 93.46, 94.13, 90.34, 92.19, 92.86, 90.01, 87.39, 87.11, 83.52, 81.28, 76.58, 74.42, 71.33, 67.68, 66.56, 56.26, 59.12, 49.7, 57.27, 57.35, 64.17, 71.62, 76.37, 79.98, 83.32, 83.59, 87.0, 91.85, 91.27, 89.98, 95.39, 94.98, 94.77, 93.39, 94.64, 93.05, 92.28, 90.96, 91.21, 90.05, 88.2, 89.81, 89.71, 88.83, 88.86, 87.82, 90.6, 89.63, 90.93, 93.14, 87.69, 90.99, 92.18, 88.82, 85.53, 89.36, 88.65, 82.26, 82.67, 85.25, 79.13, 72.98, 76.13, 73.02, 73.0, 79.45, 80.14, 85.55, 87.67, 88.86, 90.6, 90.52, 92.86, 94.41, 91.8, 87.96, 87.29, 85.6, 77.04]
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
74.154387
0.570839
2,871
O60260
Q8IWA4
20871098, 21615408, 33082525, 23503661
UbiNet, UbiBrowser, 31181401, DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
MFN1
MAEPVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENLKPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRNAQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNASQEELMITLVTGLASVTSRTSMGIIIVGGVIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSANCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLPSSNEES
Homo sapiens
Mitochondrion outer membrane, Cytoplasm
Low tissue specificity
{'Ciliated cells': '26.7', 'Basal respiratory cells': '11.8', 'Club cells': '17.7', 'Ionocytes': '11.8', 'Mucus glandular cells': '18.9', 'Serous glandular cells': '30.8', 'Gastric mucus-secreting cells': '23.0', 'Proximal enterocytes': '10.3', 'Paneth cells': '13.1', 'Distal enterocytes': '19.4', 'Intestinal goblet cells': '17.2', 'Exocrine glandular cells': '-0.568', 'Basal prostatic cells': '24.8', 'Prostatic glandular cells': '25.8', 'Breast glandular cells': '0.503', 'Breast myoepithelial cells': '0.471', 'Glandular and luminal cells': '40.0', 'Secretory cells': '24.8', 'Basal keratinocytes': '21.7', 'Suprabasal keratinocytes': '36.2', 'Basal squamous epithelial cells': '18.8', 'Squamous epithelial cells': '25.6', 'Alveolar cells type 1': '0.082', 'Alveolar cells type 2': '0.018', 'Salivary duct cells': '17.3', 'Ductal cells': '0.458', 'Hepatocytes': '0.388', 'Cholangiocytes': '11.4', 'Proximal tubular cells': '0.127', 'Distal tubular cells': '3.1', 'Collecting duct cells': '25.3', 'Mesothelial cells': '0.335', 'Sertoli cells': '0.487', 'Granulosa cells': '10.8', 'Enteroendocrine cells': '11.3', 'Pancreatic endocrine cells': '8.5', 'Leydig cells': '0.580', 'Excitatory neurons': '74.6', 'Inhibitory neurons': '88.6', 'Cone photoreceptor cells': '28.9', 'Rod photoreceptor cells': '17.3', 'Bipolar cells': '16.0', 'Horizontal cells': '19.5', 'Astrocytes': '37.8', 'Oligodendrocyte precursor cells': '53.3', 'Oligodendrocytes': '79.2', 'Microglial cells': '26.8', 'Muller glia cells': '10.4', 'Schwann cells': '0.056', 'Spermatogonia': '0.540', 'Spermatocytes': '0.462', 'Early spermatids': '-0.304', 'Late spermatids': '-0.690', 'Oocytes': '22.1', 'Cytotrophoblasts': '10.9', 'Syncytiotrophoblasts': '12.9', 'Extravillous trophoblasts': '11.4', 'Endothelial cells': '15.5', 'Lymphatic endothelial cells': '19.2', 'Cardiomyocytes': '0.697', 'Skeletal myocytes': '-0.227', 'Smooth muscle cells': '20.2', 'Adipocytes': '19.3', 'Melanocytes': '-0.045', 'Fibroblasts': '22.4', 'Peritubular cells': '0.481', 'Endometrial stromal cells': '27.6', 'Ovarian stromal cells': '11.5', 'Undifferentiated cells': '14.1', 'T-cells': '13.3', 'B-cells': '29.2', 'Plasma cells': '25.5', 'Nk-cells': '21.9', 'Granulocytes': '12.7', 'Monocytes': '23.4', 'Macrophages': '14.7', 'Hofbauer cells': '8.7', 'Kupffer cells': '11.8', 'Dendritic cells': '22.2', 'Langerhans cells': '0.150', 'Erythroid cells': '-0.018', 'Adipocytes (Subcutaneous)': '-0.064', 'Adipocytes (Visceral)': '-0.076', 'Breast glandular cells (progenitors)': '0.381', 'Adipocytes (Breast)': '-0.393', 'Colon enterocytes': '-0.052', 'Colon enteroendocrine cells': '0.192', 'Enteric glia cells': '-0.085', 'Mitotic cells (Colon)': '0.010', 'Mitotic cells (Heart)': '0.488', 'Podocytes': '-0.103', 'Ascending Loop of Henle cells': '0.454', 'Intercalated cells': '-0.047', 'Cholangiocyte': '0.235', 'NK-cells (Liver)': '-0.284', 'Respiratory ciliated cells': '0.109', 'Mitotic cells (Lung)': '0.069', 'NK-cells (Lung)': '0.139', 'B-cells (Lung)': '0.020', 'Alpha cells': '0.264', 'Beta cells': '0.134', 'Prostate glandular cells': '0.245', 'Prostate basal glandular cells': '0.354', 'Urothelial cells': '0.145', 'Keratinocyte (other)': '-0.015', 'Keratinocyte (granular)': '-0.063', 'Hair cortex cells': '-0.091', 'Inner root sheath cells': '-0.066', 'Outer root sheath cells': '0.108', 'Sebaceous gland cells': '0.174', 'Eccrine sweat gland cells': '-0.041', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.132', 'Parietal cells': '-0.349', 'Chief cells': '-0.242', 'Gastric mucous cells': '-0.190', 'Gastric enteroendocrine cells': '-0.207', 'Mitotic cells (Stomach)': '0.070', 'Parafollicular cells': '0.025', 'Thyroid glandular cells': '0.083', 'Mitotic cells (Thyroid)': '0.084', 'Adrenal cortex cells': '0.534', 'Adrenal medulla cells': '0.024', 'Mitotic cells (Adrenal gland)': '0.319', 'Minor salivary glandular cells': '0.195', 'Minor salivary gland ductal cells': '0.035', 'Minor salivary gland basal cells': '0.501', 'Mitotic cells (Minor salivary gland)': '0.352', 'Adipocytes (Minor salivary gland)': '0.088', 'Somatotropes': '0.067', 'Lactotropes': '-0.007', 'Gonadotropes': '0.151', 'Corticotropes': '-0.069', 'Thyrotropes': '0.017', 'Undifferentiated cells (Pituitary gland)': '0.063', 'Mitotic cells (Spleen)': '-0.173', 'Platelets': '-0.105', 'Erythrocytes': '-0.121', 'Hematopoietic stem cells': '-0.232', 'B-cells (Spleen)': '0.601', 'NK-cells (Spleen)': '0.305', 'Amygdala excitatory': '83.8', 'Cerebellar inhibitory': '120.1', 'Cge interneuron': '134.1', 'Deep-layer corticothalamic and 6b': '112.3', 'Deep-layer intratelencephalic': '110.7', 'Deep-layer near-projecting': '130.6', 'Eccentric medium spiny neuron': '64.7', 'Hippocampal ca1-3': '101.8', 'Hippocampal ca4': '89.1', 'Hippocampal dentate gyrus': '67.5', 'Lamp5-lhx6 and chandelier': '131.7', 'Lower rhombic lip': '122.9', 'Mammillary body': '129.5', 'Medium spiny neuron': '54.1', 'Mge interneuron': '137.4', 'Midbrain-derived inhibitory': '118.7', 'Miscellaneous': '94.3', 'Splatter': '109.4', 'Thalamic excitatory': '126.4', 'Upper rhombic lip': '106.5', 'Upper-layer intratelencephalic': '87.4', 'Astrocyte': '67.7', 'Bergmann glia': '88.1', 'Central nervous system macrophage': '65.8', 'Choroid plexus epithelial cell': '79.6', 'Committed oligodendrocyte precursor': '84.5', 'Ependymal cell': '72.7', 'Oligodendrocyte': '137.8', 'Oligodendrocyte precursor cell': '98.5', 'Endothelial cell': '66.0', 'Pericyte': '67.4', 'Vascular associated smooth muscle cell': '62.1', 'Fibroblast': '73.4', 'Leukocyte': '69.8', 'Basophil': '53.1', 'Eosinophil': '5.8', 'Neutrophil': '53.8', 'Classical monocyte': '20.5', 'Non-classical monocyte': '27.5', 'Intermediate monocyte': '27.6', 'T-reg': '18.7', 'GdT-cell': '2.6', 'MAIT T-cell': '16.8', 'Memory CD4 T-cell': '3.0', 'Naive CD4 T-cell': '45.3', 'Memory CD8 T-cell': '2.7', 'Naive CD8 T-cell': '38.5', 'Memory B-cell': '5.0', 'Naive B-cell': '104.8', 'Plasmacytoid DC': '27.9', 'Myeloid DC': '12.9', 'NK-cell': '37.7', 'Total PBMC': '16.2', 'Vd2 gdTCR': '22.6', 'Memory CD4 T-cell Th1\\/Th17': '37.7', 'Memory CD4 T-cell Th17': '32.3', 'Memory CD4 T-cell Th2': '37.3', 'Non-Vd2 gdTCR': '20.2', 'Memory CD4 T-cell Th1': '33.0', 'Memory CD4 T-cell TFH': '33.4', 'Terminal effector memory CD4 T-cell': '23.0', 'Central memory CD8 T-cell': '31.0', 'Effector memory CD8 T-cell': '27.9', 'Terminal effector memory CD8 T-cell': '23.9', 'Non-switched memory B-cell': '44.1', 'Plasmablast': '20.1', 'Switched memory B-cell': '36.7', 'Exhausted memory B-cell': '37.0', 'Progenitor cell': '23.1', 'Memory T-reg': '33.6', 'Naive CD4 T-cell activated': '38.9', 'Naive CD8 T-cell activated': '39.6', 'Naive T-reg': '45.5'}
5GNR, 5GNS, 5GNT, 5GNU, 5GO4, 5GOE, 5GOF, 5GOM, 5YEW
{'Adipose Tissue': 19.705598837209305, 'Adrenal Gland': 17.453736434108528, 'Bladder': 23.056190476190476, 'Blood': 16.375358234660926, 'Blood Vessel': 26.67100374531835, 'Brain': 12.688649394398182, 'Breast': 21.932222222222222, 'Cervix Uteri': 31.48631578947369, 'Colon': 20.83466110397946, 'Esophagus': 23.52734186851211, 'Fallopian Tube': 29.21888888888889, 'Heart': 14.139229268292684, 'Kidney': 11.422775280898875, 'Liver': 6.88166371681416, 'Lung': 21.86719204152249, 'Muscle': 12.900124533001245, 'Nerve': 27.731017770597735, 'Ovary': 26.44511111111111, 'Pancreas': 15.30508231707317, 'Pituitary': 19.03511660777385, 'Prostate': 24.217428571428577, 'Salivary Gland': 21.555432098765433, 'Skin': 25.938712548369267, 'Small Intestine': 23.05411229946524, 'Spleen': 25.869970954356845, 'Stomach': 19.543551532033423, 'Testis': 17.64294182825485, 'Thyroid': 22.16028637059724, 'Uterus': 31.438591549295772, 'Vagina': 27.65820512820513}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
81.540108
0.379204
784
O60260
Q8IXI1
22078885, 33082525, 23503661
UbiNet, UbiBrowser, DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
RHOT2
MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDEELREEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEAVLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEELNAFQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPVELQSLFSVFPAAPWGPELPRTVRTEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPGYAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVACLMFDGSDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLATMAAFPHLVHAELHPSSFWLRGLLGVVGAAVAAVLSFSLYRVLVKSQ
Homo sapiens
Mitochondrion outer membrane
Low tissue specificity
{'Ciliated cells': '25.8', 'Basal respiratory cells': '77.4', 'Club cells': '39.9', 'Ionocytes': '97.2', 'Mucus glandular cells': '17.3', 'Serous glandular cells': '24.2', 'Gastric mucus-secreting cells': '47.8', 'Proximal enterocytes': '45.1', 'Paneth cells': '44.8', 'Distal enterocytes': '53.8', 'Intestinal goblet cells': '45.8', 'Exocrine glandular cells': '-0.622', 'Basal prostatic cells': '18.6', 'Prostatic glandular cells': '28.4', 'Breast glandular cells': '0.666', 'Breast myoepithelial cells': '0.541', 'Glandular and luminal cells': '19.2', 'Secretory cells': '20.7', 'Basal keratinocytes': '32.6', 'Suprabasal keratinocytes': '27.4', 'Basal squamous epithelial cells': '20.8', 'Squamous epithelial cells': '17.5', 'Alveolar cells type 1': '-0.097', 'Alveolar cells type 2': '-0.459', 'Salivary duct cells': '19.1', 'Ductal cells': '0.495', 'Hepatocytes': '-0.098', 'Cholangiocytes': '26.7', 'Proximal tubular cells': '0.148', 'Distal tubular cells': '12.3', 'Collecting duct cells': '35.0', 'Mesothelial cells': '0.376', 'Sertoli cells': '0.410', 'Granulosa cells': '16.9', 'Enteroendocrine cells': '51.9', 'Pancreatic endocrine cells': '35.7', 'Leydig cells': '0.314', 'Excitatory neurons': '45.0', 'Inhibitory neurons': '34.8', 'Cone photoreceptor cells': '217.5', 'Rod photoreceptor cells': '294.7', 'Bipolar cells': '101.8', 'Horizontal cells': '87.5', 'Astrocytes': '50.5', 'Oligodendrocyte precursor cells': '16.0', 'Oligodendrocytes': '25.4', 'Microglial cells': '19.7', 'Muller glia cells': '37.4', 'Schwann cells': '-0.018', 'Spermatogonia': '0.106', 'Spermatocytes': '-0.155', 'Early spermatids': '-0.501', 'Late spermatids': '-0.469', 'Oocytes': '7.4', 'Cytotrophoblasts': '64.4', 'Syncytiotrophoblasts': '66.6', 'Extravillous trophoblasts': '53.5', 'Endothelial cells': '23.8', 'Lymphatic endothelial cells': '17.6', 'Cardiomyocytes': '0.594', 'Skeletal myocytes': '-0.233', 'Smooth muscle cells': '24.0', 'Adipocytes': '28.5', 'Melanocytes': '-0.226', 'Fibroblasts': '23.5', 'Peritubular cells': '0.328', 'Endometrial stromal cells': '20.0', 'Ovarian stromal cells': '30.0', 'Undifferentiated cells': '42.2', 'T-cells': '38.3', 'B-cells': '34.0', 'Plasma cells': '18.7', 'Nk-cells': '41.4', 'Granulocytes': '17.9', 'Monocytes': '33.8', 'Macrophages': '25.1', 'Hofbauer cells': '34.4', 'Kupffer cells': '23.2', 'Dendritic cells': '25.2', 'Langerhans cells': '0.037', 'Erythroid cells': '0.086', 'Adipocytes (Subcutaneous)': '-0.199', 'Adipocytes (Visceral)': '-0.292', 'Breast glandular cells (progenitors)': '0.473', 'Adipocytes (Breast)': '-0.571', 'Colon enterocytes': '-0.026', 'Colon enteroendocrine cells': '0.080', 'Enteric glia cells': '0.421', 'Mitotic cells (Colon)': '-0.001', 'Mitotic cells (Heart)': '0.362', 'Podocytes': '-0.147', 'Ascending Loop of Henle cells': '0.448', 'Intercalated cells': '-0.092', 'Cholangiocyte': '0.218', 'NK-cells (Liver)': '-0.038', 'Respiratory ciliated cells': '0.146', 'Mitotic cells (Lung)': '-0.117', 'NK-cells (Lung)': '0.304', 'B-cells (Lung)': '0.241', 'Alpha cells': '0.399', 'Beta cells': '0.307', 'Prostate glandular cells': '0.200', 'Prostate basal glandular cells': '0.462', 'Urothelial cells': '0.378', 'Keratinocyte (other)': '-0.221', 'Keratinocyte (granular)': '-0.330', 'Hair cortex cells': '0.032', 'Inner root sheath cells': '-0.007', 'Outer root sheath cells': '0.297', 'Sebaceous gland cells': '0.075', 'Eccrine sweat gland cells': '0.079', 'Adipocytes (Skin)': '0.029', 'Mitotic cells (Skin)': '-0.041', 'Parietal cells': '-0.329', 'Chief cells': '-0.372', 'Gastric mucous cells': '0.077', 'Gastric enteroendocrine cells': '-0.133', 'Mitotic cells (Stomach)': '0.200', 'Parafollicular cells': '0.052', 'Thyroid glandular cells': '-0.029', 'Mitotic cells (Thyroid)': '-0.082', 'Adrenal cortex cells': '0.199', 'Adrenal medulla cells': '-0.043', 'Mitotic cells (Adrenal gland)': '-0.376', 'Minor salivary glandular cells': '0.467', 'Minor salivary gland ductal cells': '0.314', 'Minor salivary gland basal cells': '0.121', 'Mitotic cells (Minor salivary gland)': '0.041', 'Adipocytes (Minor salivary gland)': '0.140', 'Somatotropes': '0.250', 'Lactotropes': '0.228', 'Gonadotropes': '0.049', 'Corticotropes': '0.031', 'Thyrotropes': '0.091', 'Undifferentiated cells (Pituitary gland)': '-0.152', 'Mitotic cells (Spleen)': '-0.463', 'Platelets': '-0.190', 'Erythrocytes': '-0.094', 'Hematopoietic stem cells': '-0.341', 'B-cells (Spleen)': '0.433', 'NK-cells (Spleen)': '0.312', 'Amygdala excitatory': '47.2', 'Cerebellar inhibitory': '46.5', 'Cge interneuron': '38.0', 'Deep-layer corticothalamic and 6b': '52.4', 'Deep-layer intratelencephalic': '53.7', 'Deep-layer near-projecting': '43.2', 'Eccentric medium spiny neuron': '43.1', 'Hippocampal ca1-3': '58.8', 'Hippocampal ca4': '44.9', 'Hippocampal dentate gyrus': '36.2', 'Lamp5-lhx6 and chandelier': '42.9', 'Lower rhombic lip': '32.1', 'Mammillary body': '33.8', 'Medium spiny neuron': '52.0', 'Mge interneuron': '49.5', 'Midbrain-derived inhibitory': '36.5', 'Miscellaneous': '59.1', 'Splatter': '33.7', 'Thalamic excitatory': '43.0', 'Upper rhombic lip': '37.3', 'Upper-layer intratelencephalic': '61.6', 'Astrocyte': '57.1', 'Bergmann glia': '31.1', 'Central nervous system macrophage': '31.4', 'Choroid plexus epithelial cell': '36.1', 'Committed oligodendrocyte precursor': '36.6', 'Ependymal cell': '23.6', 'Oligodendrocyte': '26.9', 'Oligodendrocyte precursor cell': '32.6', 'Endothelial cell': '27.8', 'Pericyte': '27.5', 'Vascular associated smooth muscle cell': '22.1', 'Fibroblast': '28.8', 'Leukocyte': '35.1', 'Basophil': '74.4', 'Eosinophil': '21.8', 'Neutrophil': '76.4', 'Classical monocyte': '38.1', 'Non-classical monocyte': '32.0', 'Intermediate monocyte': '90.9', 'T-reg': '115.5', 'GdT-cell': '23.0', 'MAIT T-cell': '115.6', 'Memory CD4 T-cell': '18.4', 'Naive CD4 T-cell': '44.0', 'Memory CD8 T-cell': '18.4', 'Naive CD8 T-cell': '62.2', 'Memory B-cell': '11.7', 'Naive B-cell': '32.3', 'Plasmacytoid DC': '102.0', 'Myeloid DC': '76.3', 'NK-cell': '61.8', 'Total PBMC': '94.9', 'Vd2 gdTCR': '126.1', 'Memory CD4 T-cell Th1\\/Th17': '55.2', 'Memory CD4 T-cell Th17': '83.5', 'Memory CD4 T-cell Th2': '82.0', 'Non-Vd2 gdTCR': '121.2', 'Memory CD4 T-cell Th1': '97.4', 'Memory CD4 T-cell TFH': '142.3', 'Terminal effector memory CD4 T-cell': '131.6', 'Central memory CD8 T-cell': '115.5', 'Effector memory CD8 T-cell': '124.6', 'Terminal effector memory CD8 T-cell': '115.8', 'Non-switched memory B-cell': '91.9', 'Plasmablast': '73.4', 'Switched memory B-cell': '91.2', 'Exhausted memory B-cell': '77.2', 'Progenitor cell': '70.3', 'Memory T-reg': '124.3', 'Naive CD4 T-cell activated': '34.8', 'Naive CD8 T-cell activated': '43.8', 'Naive T-reg': '74.2'}
5KUT
{'Adipose Tissue': 97.50428571428571, 'Adrenal Gland': 108.78864341085271, 'Bladder': 125.1295238095238, 'Blood': 72.75531001076426, 'Blood Vessel': 108.27249438202249, 'Brain': 76.7633508705526, 'Breast': 118.3665577342048, 'Cervix Uteri': 154.6094736842105, 'Colon': 117.3908215661104, 'Esophagus': 103.91763321799309, 'Fallopian Tube': 156.26666666666668, 'Heart': 61.19721951219512, 'Kidney': 89.53707865168539, 'Liver': 50.489734513274335, 'Lung': 130.24681660899654, 'Muscle': 42.1007596513076, 'Nerve': 149.63347334410338, 'Ovary': 141.68561111111111, 'Pancreas': 43.101006097560976, 'Pituitary': 173.7309893992933, 'Prostate': 180.7913469387755, 'Salivary Gland': 99.97154320987654, 'Skin': 103.93099502487564, 'Small Intestine': 140.53192513368984, 'Spleen': 182.2036929460581, 'Stomach': 92.72384401114206, 'Testis': 146.5476731301939, 'Thyroid': 192.0420980091884, 'Uterus': 154.62788732394367, 'Vagina': 129.49320512820512}
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
88.721133
0.3411
1,210
O60260
Q8IXI2
26254304, 23503661
UbiNet, UbiBrowser, 31181401, DegPred
PRKN
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
Homo sapiens
Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion, Mitochondrion outer membrane, Cell projection, neuron projection, Postsynaptic density, Presynapse
Tissue enhanced (skeletal muscle, tongue)
{'Ciliated cells': '2.5', 'Basal respiratory cells': '0.9', 'Club cells': '2.4', 'Ionocytes': '1.5', 'Mucus glandular cells': '4.0', 'Serous glandular cells': '1.9', 'Gastric mucus-secreting cells': '1.8', 'Proximal enterocytes': '2.6', 'Paneth cells': '2.1', 'Distal enterocytes': '1.6', 'Intestinal goblet cells': '1.9', 'Exocrine glandular cells': '-0.364', 'Basal prostatic cells': '1.6', 'Prostatic glandular cells': '2.4', 'Breast glandular cells': '0.072', 'Breast myoepithelial cells': '0.137', 'Glandular and luminal cells': '3.8', 'Secretory cells': '2.5', 'Basal keratinocytes': '2.0', 'Suprabasal keratinocytes': '1.9', 'Basal squamous epithelial cells': '2.2', 'Squamous epithelial cells': '2.4', 'Alveolar cells type 1': '0.289', 'Alveolar cells type 2': '-0.232', 'Salivary duct cells': '2.1', 'Ductal cells': '0.329', 'Hepatocytes': '0.473', 'Cholangiocytes': '0.0', 'Proximal tubular cells': '0.210', 'Distal tubular cells': '21.5', 'Collecting duct cells': '1.9', 'Mesothelial cells': '0.203', 'Sertoli cells': '0.161', 'Granulosa cells': '5.1', 'Enteroendocrine cells': '4.4', 'Pancreatic endocrine cells': '0.0', 'Leydig cells': '0.010', 'Excitatory neurons': '312.1', 'Inhibitory neurons': '392.1', 'Cone photoreceptor cells': '15.3', 'Rod photoreceptor cells': '10.0', 'Bipolar cells': '6.6', 'Horizontal cells': '12.6', 'Astrocytes': '362.6', 'Oligodendrocyte precursor cells': '445.2', 'Oligodendrocytes': '350.5', 'Microglial cells': '221.9', 'Muller glia cells': '4.8', 'Schwann cells': '0.052', 'Spermatogonia': '0.263', 'Spermatocytes': '0.323', 'Early spermatids': '0.334', 'Late spermatids': '0.064', 'Oocytes': '9.6', 'Cytotrophoblasts': '1.0', 'Syncytiotrophoblasts': '0.7', 'Extravillous trophoblasts': '0.3', 'Endothelial cells': '3.0', 'Lymphatic endothelial cells': '4.6', 'Cardiomyocytes': '0.801', 'Skeletal myocytes': '0.363', 'Smooth muscle cells': '3.6', 'Adipocytes': '3.2', 'Melanocytes': '0.274', 'Fibroblasts': '4.5', 'Peritubular cells': '0.078', 'Endometrial stromal cells': '2.2', 'Ovarian stromal cells': '6.8', 'Undifferentiated cells': '1.7', 'T-cells': '2.3', 'B-cells': '3.8', 'Plasma cells': '1.0', 'Nk-cells': '1.0', 'Granulocytes': '2.0', 'Monocytes': '0.4', 'Macrophages': '1.3', 'Hofbauer cells': '1.1', 'Kupffer cells': '1.0', 'Dendritic cells': '2.2', 'Langerhans cells': '0.078', 'Erythroid cells': '0.039', 'Adipocytes (Subcutaneous)': '0.097', 'Adipocytes (Visceral)': '0.301', 'Breast glandular cells (progenitors)': '0.044', 'Adipocytes (Breast)': '0.090', 'Colon enterocytes': '-0.247', 'Colon enteroendocrine cells': '0.177', 'Enteric glia cells': '-0.121', 'Mitotic cells (Colon)': '-0.212', 'Mitotic cells (Heart)': '0.360', 'Podocytes': '0.061', 'Ascending Loop of Henle cells': '0.504', 'Intercalated cells': '0.265', 'Cholangiocyte': '0.156', 'NK-cells (Liver)': '0.012', 'Respiratory ciliated cells': '0.040', 'Mitotic cells (Lung)': '-0.139', 'NK-cells (Lung)': '0.248', 'B-cells (Lung)': '0.131', 'Alpha cells': '0.298', 'Beta cells': '0.182', 'Prostate glandular cells': '-0.327', 'Prostate basal glandular cells': '-0.238', 'Urothelial cells': '-0.201', 'Keratinocyte (other)': '0.030', 'Keratinocyte (granular)': '-0.220', 'Hair cortex cells': '0.391', 'Inner root sheath cells': '0.458', 'Outer root sheath cells': '0.486', 'Sebaceous gland cells': '0.047', 'Eccrine sweat gland cells': '0.201', 'Adipocytes (Skin)': '0.074', 'Mitotic cells (Skin)': '0.401', 'Parietal cells': '-0.459', 'Chief cells': '-0.514', 'Gastric mucous cells': '-0.605', 'Gastric enteroendocrine cells': '-0.522', 'Mitotic cells (Stomach)': '-0.328', 'Parafollicular cells': '0.119', 'Thyroid glandular cells': '0.448', 'Mitotic cells (Thyroid)': '0.021', 'Adrenal cortex cells': '0.795', 'Adrenal medulla cells': '0.076', 'Mitotic cells (Adrenal gland)': '0.494', 'Minor salivary glandular cells': '0.190', 'Minor salivary gland ductal cells': '0.160', 'Minor salivary gland basal cells': '-0.003', 'Mitotic cells (Minor salivary gland)': '-0.020', 'Adipocytes (Minor salivary gland)': '0.244', 'Somatotropes': '0.001', 'Lactotropes': '0.038', 'Gonadotropes': '-0.013', 'Corticotropes': '0.388', 'Thyrotropes': '0.276', 'Undifferentiated cells (Pituitary gland)': '-0.001', 'Mitotic cells (Spleen)': '-0.292', 'Platelets': '-0.215', 'Erythrocytes': '-0.154', 'Hematopoietic stem cells': '-0.228', 'B-cells (Spleen)': '0.172', 'NK-cells (Spleen)': '0.195', 'Amygdala excitatory': '726.2', 'Cerebellar inhibitory': '642.8', 'Cge interneuron': '551.4', 'Deep-layer corticothalamic and 6b': '730.6', 'Deep-layer intratelencephalic': '775.5', 'Deep-layer near-projecting': '599.2', 'Eccentric medium spiny neuron': '678.6', 'Hippocampal ca1-3': '683.9', 'Hippocampal ca4': '796.6', 'Hippocampal dentate gyrus': '705.9', 'Lamp5-lhx6 and chandelier': '699.0', 'Lower rhombic lip': '408.5', 'Mammillary body': '525.5', 'Medium spiny neuron': '895.2', 'Mge interneuron': '738.5', 'Midbrain-derived inhibitory': '688.2', 'Miscellaneous': '631.8', 'Splatter': '518.1', 'Thalamic excitatory': '491.3', 'Upper rhombic lip': '287.4', 'Upper-layer intratelencephalic': '569.5', 'Astrocyte': '879.4', 'Bergmann glia': '1229.8', 'Central nervous system macrophage': '700.5', 'Choroid plexus epithelial cell': '508.0', 'Committed oligodendrocyte precursor': '556.9', 'Ependymal cell': '381.4', 'Oligodendrocyte': '737.1', 'Oligodendrocyte precursor cell': '857.7', 'Endothelial cell': '352.5', 'Pericyte': '496.2', 'Vascular associated smooth muscle cell': '340.7', 'Fibroblast': '486.2', 'Leukocyte': '150.0', 'Basophil': '0.0', 'Eosinophil': '1.1', 'Neutrophil': '0.0', 'Classical monocyte': '0.2', 'Non-classical monocyte': '0.4', 'Intermediate monocyte': '1.0', 'T-reg': '4.3', 'GdT-cell': '0.3', 'MAIT T-cell': '0.7', 'Memory CD4 T-cell': '0.5', 'Naive CD4 T-cell': '2.6', 'Memory CD8 T-cell': '0.6', 'Naive CD8 T-cell': '2.7', 'Memory B-cell': '0.3', 'Naive B-cell': '1.6', 'Plasmacytoid DC': '0.2', 'Myeloid DC': '0.9', 'NK-cell': '0.3', 'Total PBMC': '1.4', 'Vd2 gdTCR': '1.0', 'Memory CD4 T-cell Th1\\/Th17': '1.8', 'Memory CD4 T-cell Th17': '1.5', 'Memory CD4 T-cell Th2': '1.5', 'Non-Vd2 gdTCR': '0.8', 'Memory CD4 T-cell Th1': '1.8', 'Memory CD4 T-cell TFH': '2.0', 'Terminal effector memory CD4 T-cell': '1.9', 'Central memory CD8 T-cell': '1.5', 'Effector memory CD8 T-cell': '0.0', 'Terminal effector memory CD8 T-cell': '2.0', 'Non-switched memory B-cell': '1.3', 'Plasmablast': '0.0', 'Switched memory B-cell': '0.6', 'Exhausted memory B-cell': '1.0', 'Progenitor cell': '2.5', 'Memory T-reg': '0.7', 'Naive CD4 T-cell activated': '0.5', 'Naive CD8 T-cell activated': '0.5', 'Naive T-reg': '3.0'}
1IYF, 2JMO, 4BM9, 4I1F, 4I1H, 5C1Z, 5C23, 5C9V, 5N2W, 5N38, 5TR5, 6GLC, 6HUE, 6N13
{}
RHOT1
MKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHISDGVADSGLTLKGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFKVFPYIPWGPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAVTVTRDKKIDLQKKQTQRNVFRCNVIGVKNCGKSGVLQALLGRNLMRQKKIREDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHVTQADLKSSTFWLRASFGATVFAVLGFAMYKALLKQR
Homo sapiens
Mitochondrion outer membrane
Low tissue specificity
{'Ciliated cells': '13.7', 'Basal respiratory cells': '12.9', 'Club cells': '16.3', 'Ionocytes': '12.9', 'Mucus glandular cells': '20.3', 'Serous glandular cells': '22.4', 'Gastric mucus-secreting cells': '16.5', 'Proximal enterocytes': '21.5', 'Paneth cells': '14.5', 'Distal enterocytes': '14.0', 'Intestinal goblet cells': '11.8', 'Exocrine glandular cells': '-0.423', 'Basal prostatic cells': '21.5', 'Prostatic glandular cells': '19.7', 'Breast glandular cells': '0.413', 'Breast myoepithelial cells': '0.459', 'Glandular and luminal cells': '14.3', 'Secretory cells': '11.1', 'Basal keratinocytes': '20.2', 'Suprabasal keratinocytes': '36.5', 'Basal squamous epithelial cells': '24.8', 'Squamous epithelial cells': '23.5', 'Alveolar cells type 1': '0.241', 'Alveolar cells type 2': '0.230', 'Salivary duct cells': '20.2', 'Ductal cells': '0.561', 'Hepatocytes': '0.443', 'Cholangiocytes': '13.4', 'Proximal tubular cells': '0.114', 'Distal tubular cells': '33.8', 'Collecting duct cells': '15.6', 'Mesothelial cells': '0.278', 'Sertoli cells': '0.447', 'Granulosa cells': '18.5', 'Enteroendocrine cells': '17.1', 'Pancreatic endocrine cells': '13.6', 'Leydig cells': '0.508', 'Excitatory neurons': '94.1', 'Inhibitory neurons': '86.1', 'Cone photoreceptor cells': '85.0', 'Rod photoreceptor cells': '54.8', 'Bipolar cells': '51.9', 'Horizontal cells': '49.7', 'Astrocytes': '84.2', 'Oligodendrocyte precursor cells': '64.1', 'Oligodendrocytes': '61.3', 'Microglial cells': '73.4', 'Muller glia cells': '107.3', 'Schwann cells': '0.086', 'Spermatogonia': '0.561', 'Spermatocytes': '0.490', 'Early spermatids': '-0.093', 'Late spermatids': '-0.533', 'Oocytes': '22.8', 'Cytotrophoblasts': '27.8', 'Syncytiotrophoblasts': '24.0', 'Extravillous trophoblasts': '21.1', 'Endothelial cells': '17.8', 'Lymphatic endothelial cells': '10.5', 'Cardiomyocytes': '0.697', 'Skeletal myocytes': '-0.075', 'Smooth muscle cells': '23.1', 'Adipocytes': '16.4', 'Melanocytes': '0.252', 'Fibroblasts': '18.6', 'Peritubular cells': '0.453', 'Endometrial stromal cells': '14.8', 'Ovarian stromal cells': '17.8', 'Undifferentiated cells': '15.6', 'T-cells': '19.0', 'B-cells': '17.3', 'Plasma cells': '13.6', 'Nk-cells': '20.6', 'Granulocytes': '20.4', 'Monocytes': '31.9', 'Macrophages': '32.9', 'Hofbauer cells': '35.7', 'Kupffer cells': '43.8', 'Dendritic cells': '10.4', 'Langerhans cells': '0.445', 'Erythroid cells': '0.034', 'Adipocytes (Subcutaneous)': '0.005', 'Adipocytes (Visceral)': '0.023', 'Breast glandular cells (progenitors)': '0.198', 'Adipocytes (Breast)': '-0.302', 'Colon enterocytes': '-0.243', 'Colon enteroendocrine cells': '0.230', 'Enteric glia cells': '0.056', 'Mitotic cells (Colon)': '-0.192', 'Mitotic cells (Heart)': '0.431', 'Podocytes': '-0.001', 'Ascending Loop of Henle cells': '0.551', 'Intercalated cells': '0.130', 'Cholangiocyte': '0.253', 'NK-cells (Liver)': '-0.137', 'Respiratory ciliated cells': '-0.054', 'Mitotic cells (Lung)': '0.081', 'NK-cells (Lung)': '-0.058', 'B-cells (Lung)': '-0.221', 'Alpha cells': '0.394', 'Beta cells': '0.294', 'Prostate glandular cells': '-0.368', 'Prostate basal glandular cells': '-0.076', 'Urothelial cells': '-0.025', 'Keratinocyte (other)': '0.671', 'Keratinocyte (granular)': '0.117', 'Hair cortex cells': '-0.311', 'Inner root sheath cells': '-0.245', 'Outer root sheath cells': '-0.086', 'Sebaceous gland cells': '-0.060', 'Eccrine sweat gland cells': '-0.325', 'Adipocytes (Skin)': '-0.461', 'Mitotic cells (Skin)': '0.326', 'Parietal cells': '-0.282', 'Chief cells': '-0.319', 'Gastric mucous cells': '-0.365', 'Gastric enteroendocrine cells': '-0.274', 'Mitotic cells (Stomach)': '-0.083', 'Parafollicular cells': '0.123', 'Thyroid glandular cells': '0.552', 'Mitotic cells (Thyroid)': '-0.046', 'Adrenal cortex cells': '0.662', 'Adrenal medulla cells': '-0.019', 'Mitotic cells (Adrenal gland)': '0.335', 'Minor salivary glandular cells': '0.290', 'Minor salivary gland ductal cells': '-0.028', 'Minor salivary gland basal cells': '0.553', 'Mitotic cells (Minor salivary gland)': '0.587', 'Adipocytes (Minor salivary gland)': '0.156', 'Somatotropes': '-0.108', 'Lactotropes': '0.020', 'Gonadotropes': '0.095', 'Corticotropes': '-0.026', 'Thyrotropes': '0.299', 'Undifferentiated cells (Pituitary gland)': '0.242', 'Mitotic cells (Spleen)': '-0.180', 'Platelets': '0.001', 'Erythrocytes': '-0.008', 'Hematopoietic stem cells': '0.005', 'B-cells (Spleen)': '0.104', 'NK-cells (Spleen)': '0.295', 'Amygdala excitatory': '139.3', 'Cerebellar inhibitory': '127.3', 'Cge interneuron': '130.5', 'Deep-layer corticothalamic and 6b': '113.8', 'Deep-layer intratelencephalic': '140.8', 'Deep-layer near-projecting': '127.2', 'Eccentric medium spiny neuron': '121.0', 'Hippocampal ca1-3': '149.4', 'Hippocampal ca4': '114.4', 'Hippocampal dentate gyrus': '165.5', 'Lamp5-lhx6 and chandelier': '149.3', 'Lower rhombic lip': '120.9', 'Mammillary body': '131.4', 'Medium spiny neuron': '122.6', 'Mge interneuron': '123.2', 'Midbrain-derived inhibitory': '144.2', 'Miscellaneous': '140.0', 'Splatter': '111.5', 'Thalamic excitatory': '142.3', 'Upper rhombic lip': '126.5', 'Upper-layer intratelencephalic': '161.1', 'Astrocyte': '148.5', 'Bergmann glia': '94.1', 'Central nervous system macrophage': '204.4', 'Choroid plexus epithelial cell': '130.9', 'Committed oligodendrocyte precursor': '109.5', 'Ependymal cell': '105.3', 'Oligodendrocyte': '103.7', 'Oligodendrocyte precursor cell': '119.3', 'Endothelial cell': '94.6', 'Pericyte': '106.3', 'Vascular associated smooth muscle cell': '93.6', 'Fibroblast': '118.3', 'Leukocyte': '88.0', 'Basophil': '29.8', 'Eosinophil': '5.4', 'Neutrophil': '102.1', 'Classical monocyte': '61.0', 'Non-classical monocyte': '59.0', 'Intermediate monocyte': '55.2', 'T-reg': '22.3', 'GdT-cell': '2.1', 'MAIT T-cell': '26.9', 'Memory CD4 T-cell': '2.3', 'Naive CD4 T-cell': '45.3', 'Memory CD8 T-cell': '2.2', 'Naive CD8 T-cell': '37.1', 'Memory B-cell': '2.1', 'Naive B-cell': '31.6', 'Plasmacytoid DC': '23.6', 'Myeloid DC': '45.1', 'NK-cell': '37.9', 'Total PBMC': '27.2', 'Vd2 gdTCR': '19.6', 'Memory CD4 T-cell Th1\\/Th17': '43.5', 'Memory CD4 T-cell Th17': '37.6', 'Memory CD4 T-cell Th2': '39.6', 'Non-Vd2 gdTCR': '32.7', 'Memory CD4 T-cell Th1': '35.0', 'Memory CD4 T-cell TFH': '28.7', 'Terminal effector memory CD4 T-cell': '31.2', 'Central memory CD8 T-cell': '21.9', 'Effector memory CD8 T-cell': '24.4', 'Terminal effector memory CD8 T-cell': '22.2', 'Non-switched memory B-cell': '23.0', 'Plasmablast': '28.1', 'Switched memory B-cell': '20.3', 'Exhausted memory B-cell': '23.8', 'Progenitor cell': '38.5', 'Memory T-reg': '27.4', 'Naive CD4 T-cell activated': '18.3', 'Naive CD8 T-cell activated': '18.5', 'Naive T-reg': '42.4'}
5KSO, 5KSP, 5KSY, 5KSZ, 5KTY, 5KU1, 6D71
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null
Part of a SCF-like complex, consisting of PRKN, CUL1 and FBXW7
SCF-LIKE
null
SNCAIP, SYT11, SEPTIN5, PSMD4, PACRG, LRRK2, RANBP2, SUMO1, AIMP2, PSMA7, RNF41, PINK1, CHPF, MFN2(phosphorylated), FBXO7, ZNF746, HSPA1L, HSPA1A, HSPA8, BAG4, BAG5, AMBRA1 , PRKN, CUL1 , FBXW7
SYT11, VDAC1, BCL2, CCNE1, GPR37, RHOT1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, AIMP2, PARK7,HDAC6, VDAC1,
mono, 6, 11, 48, 63
null
UBE2V1, UBE2L3, UBE2L6
null
null
78.482559
0.425398
92.470777
0.312977
1,210