title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Comparison of the antiobesity effects of the protopanaxadiol- and protopanaxatriol-type saponins of red ginseng. | A previous study demonstrated that ginseng crude saponins prevent obesity induced by a high-fat diet in rats. Ginseng crude saponins are known to contain a variety of bioactive saponins. The present study investigated and compared the antiobesity activity of protopanaxadiol (PD) and protopanaxatriol (PT) type saponins,... | 18,709,638 |
Retinal pigment epithelial cells promote spatial reorganization and differentiation of retina photoreceptors. | Retina differentiation involves the acquisition of a precise layered arrangement, with RPE cells in the first layer in intimate contact with photoreceptors in the second layer. Here, we developed an in vitro coculture model, to test the hypothesis that RPE cells play a pivotal role in organizing the spatial structure o... | 18,709,656 |
Case control MR-CISS and 3D TOF MRA imaging study of medullary compression and hypertension in hemifacial spasm. | The association between ventro-lateral medulla (VLM) compression and hypertension has not been compared between hemifacial spasm (HFS) and healthy controls using advanced magnetic resonance imaging (MRI) techniques specific for detecting neurovascular compression. We conducted a MR-constructive interference in a steady... | 18,709,669 |
Psychogenic movement disorders in children. | Psychogenic movement disorders (PMDs) are well characterized in adults, but childhood-onset PMDs have not been extensively studied. We reviewed the medical records of children who were diagnosed in our clinic with PMDs since 1988 and identified 54 patients with PMDs, representing 3.1% of our pediatric movement disorder... | 18,709,677 |
Statins: potentially useful in therapy of systemic sclerosis-related Raynaud's phenomenon and digital ulcers. | Systemic sclerosis (SSc) is characterized by fibrosis and widespread vascular pathology. Raynaud's phenomenon (RP) and digital ulceration are prominent manifestations of vascular involvement in SSc. Digital ulcers (DU) remain a serious complication, and effective therapy remains elusive. Statins display pleiotropic eff... | 18,709,692 |
Relationship between caseload volume and outcome for systemic lupus erythematosus treatment: the experience of Taiwan. | To determine if a physician's experience or hospital caseload volume is associated with in-hospital mortality of patients with systemic lupus erythematosus (SLE). We used data from Taiwan's National Health Insurance Research Database covering 2002 to 2004. A total of 8536 hospital admissions citing a principal diagnosi... | 18,709,694 |
Treatment of pilonidal sinus with primary closure. A twenty-year experience. | From 1985 to 2004, 229 patients (171 M, 58 F) aged from 16 to 35 years, affected by pilonidal sinus were treated by complete excision of the sinus and primary closure. Primary healing was achieved in 208 patients (91%) in an average time of 11.9 days. Secondary healing was achieved in 21 patients (9%) in 16-19 days. Th... | 18,709,783 |
"Open" abdominal surgery for large incisional hernias. Proposal of a personal technique. | Incisional hernia is still a serious complication of abdominal surgery because of its substantial incidence. We have to reduce the rate of complications and, if possible, correct the aesthetic defect due to the pathology itself. The complications are directly related to different factors (surgeon, technique, type of me... | 18,709,784 |
[Case report of a cervical thoracic duct cyst]. | After a number of anatomical considerations regarding the thoracic duct and the diseases that may affect it, the authors report that, in the literature, such cystic lesions of an iatrogenic nature are extremely rare in the cervical area. After discussing the diagnostic methods for a correct preoperative diagnosis, they... | 18,709,792 |
[Hematuria of papillary or medullar origin: a difficult diagnosis entity]. | Renal haemangiomas of renal papillary or medullar origin are a difficult diagnosis entity, being one of the most frequent processes of chronic episodes of hematuria, secondary to benign disease, mainly in young patients. The objective of this paper is to show the difficulty of this diagnosis and the need to suspect it ... | 18,709,811 |
[Prostatic utricle ductal carcinoma. Case report and bibliographic review]. | A case of ductal carcinoma of the prostatic utricle is described, previously known as endometrial carcinoma, and literature is reviewed. 75-years-old patient who consults for lower urinary tract obstructive symptoms, with a PSA of 8.1 ng/ml., without more symptoms. Digital rectal examination and ultrasound showed a sma... | 18,709,822 |
[The expression of NGF after rat diffuse axonal injury]. | To study the expression of nerve growth factor (NGF) in diffuse axonal injury (DAI) in rat. Eighty SD rats were used and samples were taken at 1 h, 3 h, 6 h, 12 h, 24 h, 48 h, 3 d, and 7 d after brain injury. The expressions of NGF in cerebral cortex, thalamus, cerebellum, and hippocampus were studied with immunohistoc... | 18,709,849 |
Managing risk in a challenging financial environment. | Five strategies can help hospital financial leaders balance their organizations' financial and risk positions: Understand the hospital's financial condition; Determine the desired level of risk; Consider total risk; Use a portfolio approach; Explore best-case/worst-case scenarios to measure risk. | 18,709,864 |
Effects of vitamin B12 and folate deficiency on brain development in children. | Folate deficiency in the periconceptional period contributes to neural tube defects; deficits in vitamin B12 (cobalamin) have negative consequences on the developing brain during infancy; and deficits of both vitamins are associated with a greater risk of depression during adulthood. This review examines two mechanisms... | 18,709,887 |
The worldwide challenge of the dementias: a role for B vitamins and homocysteine? | Dementia has reached epidemic proportions, with an estimated 4.6 million new cases worldwide each year. With an aging world population, the prevalence of dementia will increase dramatically in the next few decades. Of the predicted 114 million who will have dementia in 2050, about three-quarters will live in less devel... | 18,709,889 |
Physiological responses of Juncus effusus (Rush) to chromium and relevance for wastewater treatment in constructed wetlands. | Constructed wetlands are increasingly applied for industrial wastewater treatment. However, current knowledge of the stress responses of helophytes to selected toxicants such as dichromate is limited. The goal of the experiments presented here was to characterize the physiological response of Juncus effusus to differen... | 18,709,922 |
Cadmium accumulation in sunflower plants influenced by arbuscular mycorrhiza. | In order to investigate the cadmium (Cd) accumulation patterns and possible alleviation of Cd stress by mycorrhization, sunflower plants (Helianthus annuus L.) were grown in the presence or absence of Cd (20 micromol L(-1)) and inoculated or not inoculated with the arbuscular mycorrhizal fungus (AMF) Glomus intraradice... | 18,709,928 |
Nitrogen dioxide at an ambient level improves the capability of kenaf (Hibiscus cannabinus) to decontaminate cadmium. | As reported previously, atmospheric nitrogen dioxide (NO2) at an ambient level increased plant size and the contents of cell constituents. We investigated this effect of atmospheric NO2 on decontamination of cadmium (Cd) by kenaf (Hibiscus cannabinus). Seventeen-day-old seedlings of kenaf were grown in air either with ... | 18,709,933 |
Emergency preparedness for the health sector and communities--challenges and the way forward. WHO Expert Consultation. Geneva, 15-17 February 2006. | In accordance with the World Health Assembly Resolution 58.1, the World Health Organization (WHO) convened an Expert Consultation in Geneva, Switzerland from 15-17 February 2006 to discuss and provide recommendations for enhancing emergency preparedness and capacity building at the community, country, regional, and glo... | 18,709,946 |
[Transthyretin Arg-83 mutation in vitreous amyloidosis]. | Vitreous amyloidosis is a rare condition that mainly occurs in Familial Amyloidotic Polyneuropathy (FAP). In some cases, it may be the only symptom without systemic disorders. One case of familial vitreous amyloidosis was reported here, with white, wispy opacities in vitreous cavity in both eyes. Pars plana vitrectomy ... | 18,709,962 |
[A case of multi-drug resistant pulmonary tuberculosis after administration of standard anti-tuberculosis treatment for two times]. | We reported a case in which multi-drug resistant tuberculosis was recognized after two courses of anti-tuberculosis treatment. A 41-year-old woman who had received two courses of anti-tuberculosis treatment for pulmonary tuberculosis was admitted to our hospital due to productive cough, high fever and positive sputum s... | 18,709,969 |
[Chronic eosinophilic leukemia with complex karyotypic abnormalities including trisomy 8]. | We report a 61-year-old man with chronic eosinophilic leukemia (CEL). The patient was referred to our hospital because of pyrexia and eosinophilia. He was diagnosed with CEL based on an increase in blasts and eosinophils in his peripheral blood and bone marrow, and clonal complex karyotypic abnormalities including tris... | 18,709,984 |
[Evans syndrome associated with idiopathic mixed-type autoimmune hemolytic anemia]. | A 60-year-old man was admitted to our hospital with severe anemia and blood findings showed hemolytic anemia. Further serological examination revealed both warm-reactive autoantibody and cold agglutinin against erythrocytes. The cold agglutinin showed a low titer, 1 : 32 at 4 degrees C, and had a high thermal amplitude... | 18,709,985 |
[Establishment of mail medical examination system using immediate plasma separating device by the self-collection blood--the method of dilution ratio calculation by using Internal standard for the sample with different amount of collecting blood]. | A method of calibrating unquantified samples was developed in order to conduct tests from approximately 65 microl or less of self-collected whole blood from the finger. In this method, the dilution ratio is estimated by absorption analysis of an internal standard substance in the blood dilution buffer. Good results for... | 18,709,989 |
[Advancement of prophylaxis and therapy for venous thromboembolism]. | Recently in Japan, venous thromboembolism (VTE) [deep vein thrombosis (DVT)/pulmonary thromboembolism (PTE)] has increased with the Westernization of eating habits and aging of society. In the West, the prophylaxis guidelines have been discussed for many years. Unfortunately, Japan falls far behind the West in this are... | 18,709,991 |
[Educational program in the Medical Science Course, Kitasato University School of Allied Health Sciences]. | The aim of education in the Medical Laboratory Science course, Kitasato University School of Allied Health Sciences, is to bring up train students who have Kitasato spirit, for careers in laboratory medicine of hospital or scientific staff of medical companies or as researchers. General and enlightening education conce... | 18,709,993 |
[The effect of operating time of PMX-DHP on decrease of platelets]. | Recently, it is said that long-term PMX-DHP is beneficial for severe septic shock. Decrease in platelets, however, is one of the problems of PMX-DHP. We retrospectively examined the effect of operating time of PMX-DHP on decrease of platelets. Forty-nine subjects were divided into three subgroups by their operating tim... | 18,709,997 |
[Use of landiolol hydrochloride for the prevention of atrial fibrillation after lung resection]. | We examined the effect of landiolol hydrochloride, a selective beta1-adrenoreceptor antagonist, on the incidence of atrial fibrillation(AF). The incidence of AF after lung resection was evaluated retrospectively in patients with intraoperative treatment with landiolol hydrochloride or those without it. Landiolol hydroc... | 18,709,998 |
[Prevention of postoperative nausea and vomiting by metoclopramide combined with dexamethasone in gynecological surgery]. | The authors evaluated the efficacy of a combination of dexamethasone and metoclopramide for the prophylaxis of postoperative nausea and vomiting (PONV) after gynecological abdominal surgery. One-hundred and seventeen patients scheduled for gynecological abdominal surgery were analyzed retrospectively. Patients were cla... | 18,710,003 |
[Prolonged pain after left hepatectomy]. | We have experienced a patient complaining of the prolonged pain after left hepatectomy. The patient was a 53-year-old man. He underwent left hepatectomy for cholangiocellular carcinoma, and complained of prolonged abdominal pain for more than 10 days after the operation. After detailed examinations, we noticed duodenal... | 18,710,008 |
[Training of internal jugular vein cannulation: comparison of landmark method with ultrasound-guided method]. | We compared training of internal jugular vein cannulation with ultrasound-guided method and that with landmark method in a group of 10 residents and that of 10 staffs. Cannulation was increasingly successful with both methods as the training proceeded, and with increasingly less time and fewer number of punctures. Ther... | 18,710,019 |
Expression of mouse 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 mRNA alternative splice variants in hypoxia. | Expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB-3) mRNA alternative splice variants was studied in different mouse tissues in hypoxic conditions in vivo. Significant increase of the expression of PFKFB-3 mRNA was observed in the mouse lungs, testes and brain in hypoxia. Several new alternati... | 18,710,022 |
[Role of non-haem iron in protecting effect of ecdysterone on development of streptozocin-induced hyperglycaemia in rats]. | Chronic hyperglycaemia (60 days) which developed after streptozotocine (STZ) administration (5 mg/100 g) in rats was accompanied with development of severe endothelial dysfunction as well as with disturbed non-haem iron metabolism. It was established by EPR spectroscopy method that STZ administration reduced transferri... | 18,710,026 |
[Elastolytic activity of bronchoalveolar lavage fluid in acute lung inflammatory injury]. | Elastolytic activity in bronchoalveolar lavage fluid in the lung with acute inflammatory injury and properties of different proteinase inhibitors for its correction was established. It was determined, that 4/5 of elastolytic activities are submitted to neutrophile serine proteinase (EC 3.4.21.37) and 1/5 of elastolytic... | 18,710,032 |
[Efficiency of partial pneumonectomies in patients with multidrug-resistant tuberculosis]. | The immediate results of partial resections were analyzed in 120 patients with drug-resistant pulmonary tuberculosis, among whom 70 patients had multidrug resistance. A complete clinical effect (abacillation and no decay cavities) was achieved in 117 (97.5%) patients, including in 67 (95.7%) patients with multidrug res... | 18,710,039 |
[New-onset pulmonary tuberculosis patients with schizophrenia: course and efficiency of treatment]. | To investigate the specific features of the course and efficiency of treatment, the authors examined 72 patients with new-onset pulmonary tuberculosis and schizophrenia versus 68 new-onset pulmonary tuberculosis patients without mental diseases. Tuberculosis has been found to be identified in 66.7% of schizophrenics by... | 18,710,046 |
[Real-time polymerase chain reaction in the diagnosis of pulmonary tuberculosis]. | To enhance the efficiency of diagnosis of oligo- and abacillar pulmonary tuberculosis and its differential diagnosis with other lung diseases, the authors studied the informative value of real-time polymerase chain reaction (PCR) used in 62 patients with different clinical forms of tuberculosis and 108 differentially d... | 18,710,048 |
[Evaluation of nonspecific responsiveness from adaptive reactions in patients with destructive pulmonary tuberculosis]. | The frequency and nature of adaptive reactions were studied by the procedure described by L. Kh. Garkavi in 308 patients with destructive pulmonary tuberculosis in relation to the carriage of different combinations of genetic markers. Reactions of the stress type were most frequently established in patients with caseou... | 18,710,050 |
[The role of interleukin-6 in rheumatoid arthritis]. | Cytokines such as TNF-alpha and IL-1beta play key roles in driving the inflammation and synovial cell proliferation that characterize rheumatoid arthritis (RA) joint destruction. It is, therefore, not surprising that therapies for RA have targeted these cytokines. While blockade of TNF-alpha or IL-1beta has been effica... | 18,710,059 |
Facial burning in women with leprosy, physiological or pathological? | Eight peri-menopausal women, five with borderline lepromatous leprosy and three with borderline tuberculoid leprosy, self-referred complaining of 'burning of the face. Four were seen in 1993, three having been treated as 'menopausal'without betterment and four were seen in 1997. Eight peri-menopausal women who self-ref... | 18,710,072 |
[Triptans--pivotal event in migraine treatment]. | Introducing serotonin 5-HT1B/1D agonists in the migraine treatment in the early 1990s had for the first time set guidelines for targeting a hypothetic physiologic source of the sequence of events in migraine, and results thus achieved were considerably better than those accomplished with earlier nonselective pharmacolo... | 18,710,081 |
[Headache caused by pesticides--a review of the literature]. | Headache makes one of the most common side effects of frequently pesticide application. This is to be taken care of in rural areas. Headaches have been reported with the use of ivermectin, ivermectin-diethylcarbamazine, organophosphates, and also with the fungicide maneb and copper sulfate, carbofuran, hexonal, dioxin,... | 18,710,090 |
[Diagnostic procedures in pediatric migraine]. | The "gold standard" in the diagnosis of pediatric migraine includes personal history, clinical and neurological examination. Many important data on previous morbidity, psychosocial status and recent sickness (today's headache) can be found by using an interview, "face to face", or by "headache diary". On clinical exami... | 18,710,092 |
Identification of As accumulation plant species growing on highly contaminated soils. | Soils from the alluvial flats of the Turia River, Valencia, Spain, which were highly contaminated by decades of industrial activity, were surveyed for native plant species that could be candidates useful in phytoremediation. Concentrations of heavy metals and arsenic (As) in soils reached 25,000 mg Kg(-1) Pb, 12,000 mg... | 18,710,094 |
Abdominal surgery during pregnancy: a retrospective study of 23 patients. | The aim of this study was to demonstrate that during pregnancy a large variety of non-gynaecological abdominal pathologies can be safely managed with surgery. The medical records of twenty-three patients that were pregnant and underwent open or laparoscopic surgery from 1997 to 2007 were reviewed. Twenty-one of the 23 ... | 18,710,103 |
Ischaemic caecal necrosis. | Isolated ischaemic caecal necrosis is an unusual event. Because right colon location is less frequent than left one, it may not be considered in the differential diagnosis of right lower quadrant pain. With the typical symptoms (right-sided abdominal pain and tenderness), patients are suspected of having either appendi... | 18,710,111 |
The snoring child. | Snoring is a common manifestation of obstructive sleep apnea and represents one end of the spectrum of sleep-related breathing disorders. Children with primary snoring initially may develop OSAS later, so inquiring about symptoms of OSAS should be part of each visit. Obstructive sleep apnea can result in serious cardio... | 18,710,136 |
Endosulfan sulfate sorption on natural organic substances. | This work proposes a viable remediation method based on the use of natural organic substances (NOSs) that characterize the Mediterranean region to improve the ecological system. A series of experiments, including variable conditions, such as temperature, pH, contact time, and pesticide concentration, were performed to ... | 18,710,144 |
High-solids anaerobic digestion of municipal sludge pretreated by thermal hydrolysis. | High-solids anaerobic digestion can consistently achieve 55 to 60% volatile solids destruction after thermal hydrolysis pretreatment, which reduces its viscosity and increases the fraction of soluble organic matter. For feed sludge with total solids concentrations between 6.8 and 8.2%, the process is stable at hydrauli... | 18,710,149 |
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on molar development among non-resistant inbred strains of mice: a geometric morphometric analysis. | Prenatal development is highly sensitive to the effects of environmental contaminants. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental toxicant that at very low levels causes teratogenic effects such as irregular tooth development. Variations in susceptibility to TCDD's effects have been attributed prima... | 18,710,171 |
Tandem reactions for streamlining synthesis: enantio- and diastereoselective one-pot generation of functionalized epoxy alcohols. | [Reaction: see text] In 1980, Sharpless and Katsuki introduced the asymmetric epoxidation of prochiral allylic alcohols (the Sharpless-Katsuki asymmetric epoxidation), which enabled the rapid synthesis of highly enantioenriched epoxy alcohols. This reaction was a milestone in the development of asymmetric catalysis bec... | 18,710,197 |
A combined high-resolution X-ray powder diffraction, computational, and XPS study of the local structure of extra-framework copper ions in over-exchanged Cu-MCM22 zeolite. | Local structure and site distribution of extra-framework copper ions in over-exchanged Cu-MCM22 zeolite were determined by a combination of high resolution X-ray powder diffraction and computational analysis. X-ray diffraction data suggested the presence of three Cu sites in six-membered rings and one site in a five-me... | 18,710,202 |
Energy transfer dynamics in the presence of preferential hydrogen bonding: collisions of highly vibrationally excited pyridine-h5, -d5, and -f5 with water. | The relaxation of highly vibrationally excited pyridine-h5, pyridine-d5, and pyridine-f5 (E approximately 38,000 cm(-1)) through collisions with water was investigated by high resolution transient IR absorption spectroscopy to investigate how preferential hydrogen bonding interactions impacts the energy transfer dynami... | 18,710,206 |
Nanoparticle-mediated intervalence transfer. | Nanoparticle-mediated intervalence transfer was reported with ferrocene moieties that were attached onto the ruthenium nanoparticle surface by ruthenium-carbene pi bonds. The resulting particles exhibited two pairs of voltammetric waves with a potential spacing of about 200 mV and a rather intense absorption peak in th... | 18,710,225 |
Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA. | The functions of most RNA molecules are critically dependent on the distinct local dynamics that characterize secondary structure and tertiary interactions and on structural changes that occur upon binding by proteins and small molecule ligands. Measurements of RNA dynamics at nucleotide resolution set the foundation f... | 18,710,236 |
Site-specific radical directed dissociation of peptides at phosphorylated residues. | Site-specific fragmentation of peptides at phosphorylated serine or threonine residues is demonstrated. This radical directed cleavage is accomplished by a two-step procedure. First the phosphate is replaced with naphthalenethiol using well established Michael Addition chemistry. Second, the modified peptide is electro... | 18,710,237 |
Determination of florfenicol amine residues in animal edible tissues by an indirect competitive ELISA. | Florfenicol (FF) is a broad-spectrum antibiotic used increasingly in aquaculture, livestock, and poultry to treat diseases. To avoid using labor-intensive instrumental methods to detect residues of FF in food and food products, a simple and convenient indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) me... | 18,710,242 |
Novel prediction method of beer foam stability using protein Z, barley dimeric alpha-amylase inhibitor-1 (BDAI-1) and yeast thioredoxin. | Foam stability is an important quality trait of beer. Our previous results of two-dimensional gel electrophoresis (2DE) analyses of beer proteins implied a relationship between barley dimeric alpha-amylase inhibitor-1 (BDAI-1) and beer foam stability as judged by the NIBEM-T analyzer. To develop a novel prediction meth... | 18,710,245 |
Planar cell polarity signaling: from fly development to human disease. | Most, if not all, cell types and tissues display several aspects of polarization. In addition to the ubiquitous epithelial cell polarity along the apical-basolateral axis, many epithelial tissues and organs are also polarized within the plane of the epithelium. This is generally referred to as planar cell polarity (PCP... | 18,710,302 |
Triglycerides potentiate the inflammatory response in rat Kupffer cells. | Accumulation of fat in the liver, also known as steatosis, may lead to inflammation and tissue damage. Kupffer cells (KCs) are the resident macrophages of the liver and have an important role in inflammatory reactions. The inflammatory response of isolated rat KCs to endotoxin in the presence of lipids was investigated... | 18,710,323 |
Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis. | Brainstem encephalitis (BE) is a serious neurological complication of enterovirus 71 (EV71) infection. The present study was designed to determine the characteristics of the chemokine response in the blood and cerebrospinal fluid (CSF) of patients with EV71-associated BE. Thirty-one patients with BE were studied. They ... | 18,710,325 |
Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. | Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics. We examined relevant information from the most recent influenza pandemic that occurred during the era prior to the use of a... | 18,710,327 |
Human monocytes augment invasiveness and proteolytic activity of inflammatory breast cancer. | Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer, and here, we examined in vitro the interactions between the human IBC cell line SUM149 and U937 human naive monocytes. We found an altered morphology, enhanced invasiveness and proteolytic activity of SUM149 cells when cultured with U937 cel... | 18,710,343 |
Pharmacotherapy of chronic viral hepatitis and hepatocellular carcinoma. | Hepatitis B virus (HBV) is a major etiologic agent of chronic liver disease (CLD) and hepatocellular carcinoma. Drugs have been developed and shown to be effective against HBV replication. These treatments are often associated with the resolution of CLD. However, they are too expensive, not well tolerated, and result i... | 18,710,349 |
The differential effects of thiazolidindiones on atherogenic dyslipidemia in type 2 diabetes: what is the clinical significance? | Diabetic dyslipidemia is typically characterized by an increase in plasma triglycerides, a decrease in high-density lipoprotein cholesterol and a concomitant increase in atherogenic small dense low-density lipoproteins. Thiazolidindiones are able to lower the levels of fasting glucose and glycated hemoglobin significan... | 18,710,354 |
Ajuba: a new microtubule-associated protein that interacts with BUBR1 and Aurora B at kinetochores in metaphase. | The role of the LIM-domain-containing protein Ajuba was initially described in cell adhesion and migration processes and recently in mitosis as an activator of the Aurora A kinase. In the present study, we show that Ajuba localizes to centrosomes and kinetochores during mitosis. This localization is microtubule-depende... | 18,710,370 |
Research priorities in nursing--a Delphi study among Swedish nurses. | The main aim was to illuminate essential areas for future patient-related nursing research. The secondary aim was to stimulate nurses to explore important research areas based on clinical practice. Priority-setting is regarded as one of the main strategies to ensure excellence in nursing science, to direct nursing rese... | 18,710,377 |
Allogeneic transplantation for Hodgkin lymphoma. | The majority of patients with Hodgkin lymphoma (HL) can now expect to be cured with conventional chemo- and/or radio-therapy. However, a subgroup still exists that have poor outcomes, even following dose escalation and autologous stem cell transplantation. Furthermore, patients relapsing after autografting have limited... | 18,710,379 |
Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma. | Autotaxin (ATX) is a tumour cell motility-stimulating factor originally isolated from melanoma cell supernatants. ATX is identical to lysophospholipase D, which produces a bioactive lipid mediator, lysophosphatidic acid (LPA), from lysophosphatidylcholine. ATX is overexpressed in various malignancies, including Hodgkin... | 18,710,386 |
Maxillary complete denture movement during chewing in mandibular removable partial denture wearers. | To evaluate the pattern of maxillary complete denture movement during chewing for free-end removable partial dentures (RPD) wearers, compared to maxillary and mandibular complete denture wearers. Eighteen edentulous participants (group I) and 10 volunteers with bilateral posterior edentulous mandibles (group II) compri... | 18,710,401 |
Alteration of N-glycosylation in the kidney in a mouse model of systemic lupus erythematosus: relative quantification of N-glycans using an isotope-tagging method. | Changes in the glycan structures of some glycoproteins have been observed in autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. A deficiency of alpha-mannosidase II, which is associated with branching in N-glycans, has been found to induce SLE-like glomerular nephritis in a mouse m... | 18,710,403 |
Critical role of acrolein in secondary injury following ex vivo spinal cord trauma. | The pathophysiology of spinal cord injury (SCI) is characterized by the initial, primary injury followed by secondary injury processes in which oxidative stress is a critical component. Secondary injury processes not only exacerbate pathology at the site of primary injury, but also result in spreading of injuries to th... | 18,710,419 |
Hepatic steatosis in patients with chronic hepatitis C virus genotype 2 or 3 does not affect viral response in patients treated with peginterferon alpha-2a (40KD) (PEGASYS) plus ribavirin (COPEGUS) for 16 or 24 weeks. | Hepatic steatosis is common in patients infected with hepatitis C virus (HCV). The effect of steatosis on anti-HCV therapy efficacy is unclear. We studied host and viral factors associated with steatosis and the effect of steatosis on treatment efficacy using the database of a large prospective trial in patients with H... | 18,710,427 |
Nephrectomy improves the survival of patients with locally advanced renal cell carcinoma. | To examine the cancer-specific survival of patients treated with nephrectomy and compared it to that of patients managed without surgery. Of 43,143 patients with renal cell carcinoma (RCC) identified in the 1988-2004 Surveillance, Epidemiology and End Results database, 7068 had locally advanced RCC and with no distant ... | 18,710,442 |
Effect of firing rate on the performance of shock wave lithotriptors. | To determine the mechanism that underlies the effect of shock wave (SW) rate on the performance of clinical lithotripters. The effect of firing rate on the pressure characteristics of SWs was assessed using a fibre-optic probe hydrophone (FOPH 500, RP Acoustics, Leutenbach, Germany). Shock waves were fired at slow (5-2... | 18,710,450 |
Prevalence and functional analysis of the S107P polymorphism (rs6647476) of the monocarboxylate transporter 8 (SLC16A2) gene in the male population of north-west Spain (Galicia). | Mutations in SLC16A2, the gene encoding the thyroid hormone (TH)-specific transporter monocarboxylate transporter 8 (MCT8), result in a thyroid phenotype and severe mental retardation caused by neuronal TH deficiency. These mutational effects raise the question of whether polymorphic variation in SLC16A2 may also be as... | 18,710,470 |
Multiplex preamplification of specific cDNA targets prior to gene expression analysis by TaqMan Arrays. | An accurate gene expression quantification using TaqMan Arrays (TA) could be limited by the low RNA quantity obtained from some clinical samples. The novel cDNA preamplification system, the TaqMan PreAmp Master Mix kit (TPAMMK), enables a multiplex preamplification of cDNA targets and therefore, could provide a suffici... | 18,710,479 |
Primary antimicrobial resistance among Mycobacterium tuberculosis isolates from HIV seropositive and HIV seronegative patients in Dar es Salaam Tanzania. | The United Republic of Tanzania is one of the 22 high M. tuberculosis burden countries. Data collected between 2002 and 2007 indicate that the global prevalence of drug-resistant M. tuberculosis including MDR vary greatly. The varied drug-resistance patterns make continuous surveillance of drug resistance an essential ... | 18,710,511 |
Fast comparison of DNA sequences by oligonucleotide profiling. | The comparison of DNA sequences is a traditional problem in genomics and bioinformatics. Many new opportunities emerge due to the improvement of personal computers, allowing the implementation of novel strategies of analysis. We describe a new program, called UVWORD, which determines the number of times that each DNA w... | 18,710,530 |
Carbon monoxide poisoning in a patient with carbon dioxide retention: a therapeutic challenge. | We present the case of a 70 year-old man with carbon monoxide poisoning following a house fire. A significant smoking history and likely underlying chronic lung pathology complicated treatment, as due to symptomatic retention of carbon dioxide we were unable to use high-flow oxygen to facilitate the elimination of car... | 18,710,551 |
Neurocysticercosis as a first presentation of tonic-clonic seizures: a case report. | We report the case of a 28 year-old immigrant Asian man from the Punjab region with a first presentation of seizures. This patient had no significant past medical history, but suffered several headaches in the preceding week and was pyrexial on presentation. A CT scan of his head showed a single area of subcortical lo... | 18,710,554 |
Dry season ecology of Anopheles gambiae complex mosquitoes in The Gambia. | Malaria in The Gambia is highly seasonal, with transmission occurring as Anopheles gambiae s.l. populations expand during and immediately after a single annual rainy season that lasts from June to October. There has been very limited investigation of the ecology of vectors during the dry season, when numbers are very l... | 18,710,559 |
Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic mice. | Interleukin 1 beta (IL-1beta) plays an important role in a number of chronic and acute inflammatory diseases. To understand the role of IL-1beta in disease processes and develop an in vivo screening system for anti-inflammatory drugs, a transgenic mouse line was generated which incorporated the transgene firefly lucife... | 18,710,581 |
Trichinella spiralis: nurse cell formation with emphasis on analogy to muscle cell repair. | Trichinella infection results in formation of a capsule in infected muscles. The capsule is a residence of the parasite which is composed of the nurse cell and fibrous wall. The process of nurse cell formation is complex and includes infected muscle cell response (de-differentiation, cell cycle re-entry and arrest) an... | 18,710,582 |
Salvaging Affymetrix probes after probe-level re-annotation. | Affymetrix GeneChips can be re-annotated at the probe-level by breaking up the original probe-sets and recomposing new probe-sets based on up-to-date genomic knowledge, such as available in Entrez Gene. This results in custom Chip Description Files (CDF). Using these custom CDFs improves the quality of the data and thu... | 18,710,586 |
High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis? | Self-reactive T cells with low signalling capacity through the T-cell receptor were recently observed in the SKG mouse model of rheumatoid arthritis (RA) and have been linked to a spontaneous mutation in the ZAP-70 signal transduction molecule. Here we hypothesize that similar mechanisms also drive RA, associated with ... | 18,710,589 |
Music, memory and emotion. | Because emotions enhance memory processes and music evokes strong emotions, music could be involved in forming memories, either about pieces of music or about episodes and information associated with particular music. A recent study in BMC Neuroscience has given new insights into the role of emotion in musical memory. | 18,710,596 |
[Observation on myeloid origin of neovascular endothelial cells and infiltration of bone marrow-originated inflammatory cells in a murine tumor model]. | Some studies indicate that endothelial progenitor cells (EPCs) originated from the bone marrow participate in neoplastic angiogenesis, and that bone marrow origin of inflammatory cells potentially contribute to neoplastic invasion, angiogenesis and metastasis. This study was to observe the origin of neovascular endothe... | 18,710,618 |
Prenatal inflammatory effects on nigrostriatal development in organotypic cultures. | Maternal intrauterine infection, and the accompanying inflammation in the fetal brain, represent a significant risk to the developing fetus. Dopamine (DA) neurons have been shown to be particularly vulnerable to inflammation induced by injection of the bacterial endotoxin lipopolysaccharide (LPS). In order to further e... | 18,710,655 |
Expression of chloride intracellular channel protein 1 (CLIC1) and tumor protein D52 (TPD52) as potential biomarkers for colorectal cancer. | Unequivocal biomarkers are needed to predict susceptibility and progression of colorectal cancer. Paired samples of tumor and normal tissue from six patients with colorectal cancer of different localization, pTNM stage and grade were employed in the present study. MS analysis was used to identify differentially regulat... | 18,710,659 |
Hairy2 functions through both DNA-binding and non DNA-binding mechanisms at the neural plate border in Xenopus. | The Xenopus helix-loop-helix transcription factor Hairy2 is essential for neural crest progenitor survival and maintains cells in a mitotic undifferentiated pre-neural crest state. However, its mode of action remains largely unknown. Here we show that a Hairy2 DNA-binding mutant is unable to promote cell survival and t... | 18,710,660 |
Management of the kidney transplant recipient. | The short-term outcomes of kidney transplant recipients have improved dramatically in the past 20 years, in large part resulting from the availability of more potent immunosuppressive drugs capable of preventing or treating acute allograft rejection. Ironically, side effects from these same immunosuppressants play a ro... | 18,710,663 |
Management of hypertension in the outpatient setting. | The treatment of hypertension on an outpatient basis should be approached in a systematic manner. The diagnosis of hypertension should always be verified first before treatment is initiated and, where indicated, a workup should be done. Lifestyle modifications should be considered in all patients with hypertension. Blo... | 18,710,664 |
Ethiopian adolescents' attitudes and expectations deviate from current infant and young child feeding recommendations. | Suboptimal infant and child feeding practices are highly prevalent in many developing countries for reasons that are not entirely understood. Taking an anthropological perspective, we assessed whether nulliparous youth have formulated attitudes and expectations in the domain of infant and child feeding behaviors, the e... | 18,710,680 |
The challenge of providing infertility services to a low-income immigrant Latino population. | To provide insight into the experience of low-income immigrant Latino couples seeking infertility treatment. Qualitative interview study. Infertility clinic at a university-affiliated urban public teaching hospital. Infertile low-income immigrant Latino couples (105 women and 40 men). In-depth, tape-recorded interviews... | 18,710,703 |
Cervical ectopic pregnancy on the portio: conservative case management and clinical review. | To present a case and management of an early ectopic pregnancy on the portio. Case study and literature review. Hospital outpatient clinic. A 38-year-old woman who presented in the outpatient clinic with a 2-week history of painless acyclic vaginal bleeding. Excision of the ectopic pregnancy under local anesthesia afte... | 18,710,714 |
Persistence of androgenic effects on the production of proinflammatory cytokines by circulating antigen-presenting cells after withdrawal of testosterone treatment in aging type 2 diabetic men with partial androgen deficiency. | To test the hypothesis that T treatment withdrawal could be associated with an enhancement of proinflammatory cytokine production by peripheral blood monocytes and dendritic cells. A prospective intervention study. Tertiary university hospital. Thirteen type 2 diabetic men aged >55 years with partial androgen defici... | 18,710,716 |
Urinomas associated with posterior urethral valves. | We evaluated the incidence and clinical implications of urinomas in boys with posterior urethral valves. Our secondary aim was to evaluate the treatment modalities of urinomas. We retrospectively reviewed the hospital data of 200 patients with posterior urethral valves treated between 1953 and 2003. Documentation was s... | 18,710,723 |
Long-term followup and comparison between genotype and phenotype in 29 cases of complete androgen insensitivity syndrome. | Diagnosis and management of the complete androgen insensitivity syndrome have dramatically changed in the last few decades, with earlier diagnosis and the development of molecular biology. Some phenotypic features such as development of wolffian and mullerian remnants have been suggested to be an index of subtle residu... | 18,710,728 |
Profile of the veterans affairs urologist: results from a national survey. | The Veterans Health Administration has multiple employment arrangements for its physician staff. Urological care to veterans is provided by urologists who work in the Veterans Affairs system under 1 arrangement, including full-time Veterans Affairs, contract Veterans Affairs, part-time Veterans Affairs and fee for serv... | 18,710,738 |
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