title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
Learning from the learning curve: factors associated with successful endoscopic correction of vesicoureteral reflux using dextranomer/hyaluronic acid copolymer. | Conflicting reports exist regarding the parameters guiding successful correction of vesicoureteral reflux using dextranomer/hyaluronic acid copolymer. We performed logistic regression analysis to evaluate the effect of injected volume while adjusting for other factors potentially associated with success following dextr... | 18,710,756 |
Predictive validity of the Family Attitude Scale in people with psychosis. | Expressed Emotion (EE) strongly predicts relapse in mental disorders, but there remains a need to develop and refine brief, self-report measures. This article describes two studies testing the validity of a self-report measure of criticism or burden, the Family Attitude Scale (FAS), in relatives of patients with psycho... | 18,710,783 |
Birth measures and depression at age 31 years: the Northern Finland 1966 Birth Cohort Study. | The aim of the study was to explore whether there is an association between body size at birth measured by birth weight and ponderal index and later depression at the age of 31 years. The analyses were based on 4,007 males and 4,332 females born in 1966 in the two northernmost provinces of Finland with data on current ... | 18,710,786 |
Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. | Myosin light-chain kinase (MLCK) plays a crucial role in the cell migration and tumor metastasis. Herein, we investigated the signaling pathways involved in MLCK using ML-7, a specific inhibitor of MLCK, in breast cancer cell proliferation and migration. Our data showed that reduction of MLCK in breast cancer cells med... | 18,710,790 |
Combining experts in order to identify binding sites in yeast and mouse genomic data. | The identification of cis-regulatory binding sites in DNA is a difficult problem in computational biology. To obtain a full understanding of the complex machinery embodied in genetic regulatory networks it is necessary to know both the identity of the regulatory transcription factors and the location of their binding s... | 18,710,795 |
Using tea stalk lignocellulose as an adsorbent for separating decaffeinated tea catechins. | Lignocelluloses prepared from woody tea stalk, pine sawdust and sugarcane bagasse were used as adsorbents to isolate decaffeinated catechins from tea extracts and compared with synthetic macroporous resin HPD 600. HPD 600 had the highest adsorption capacity to catechins, followed by tea stalk lignocellulose while ligno... | 18,710,802 |
Epidermoid cysts of the velum interpositum. | The cistern of the velum interpositum is a space located between the corpus callosum dorsally and the roof of the third ventricle ventrally. Lesions located within the velum interpositum are rare and include meningiomas, pilocytic astrocytomas, atypical teratoid/rhabdoid tumors and arachnoid cysts. Epidermoid cysts in ... | 18,710,812 |
Prostaglandin E2 produced by Entamoeba histolytica binds to EP4 receptors and stimulates interleukin-8 production in human colonic cells. | Entamoeba histolytica pathogenesis in the colon occurs in a stepwise fashion. It begins with colonization of the mucin layer, which is followed by stimulation of a proinflammatory response that causes nonspecific tissue damage that may facilitate parasite invasion of the underlying colonic mucosa. Unfortunately, the pa... | 18,710,858 |
Integrating expression data with domain interaction networks. | Recent studies have revealed that alternative splicing plays an important role in the observed protein and interaction diversity. Special microarrays allow for measuring gene expression at the exon level and thus for studying alternative transcripts and their corresponding protein domain architecture. We have developed... | 18,710,874 |
Inflammatory gene polymorphisms and susceptibility to kawasaki disease and its arterial sequelae. | We tested the hypothesis that single-nucleotide polymorphisms of inflammatory genes C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-alpha) may exert influence on susceptibility to Kawasaki disease and its arterial sequelae. We analyzed the CRP +1444 C-->T and TNF-alpha -308 G-->A polymorphisms in 16... | 18,710,885 |
Acupuncture for rheumatoid arthritis: a systematic review. | The aim of this systematic review is to evaluate the available evidence, from randomized clinical trials (RCTs), of acupuncture for treating patients with RA. Systematic searches were conducted on 17 databases up to April 2008 without the language restriction. All RCTs of acupuncture, with or without electrical stimula... | 18,710,899 |
Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model. | The incidence of Clostridium difficile infection is increasing, with reports implicating fluoroquinolone use. A three-stage chemostat gut model was used to study the effects of three fluoroquinolones (ciprofloxacin, levofloxacin, and moxifloxacin) on the gut microbiota and two epidemic C. difficile strains, strains of ... | 18,710,908 |
Phenotypic characterization of two Ancylostoma caninum isolates with different susceptibilities to the anthelmintic pyrantel. | The anthelmintic pyrantel plays an important role in the control of gastrointestinal helminths of humans and domestic animals. Despite the demonstration of pyrantel resistance in several helminth species over the last 20 years, the resistance mechanism remains unclear. It has been hypothesized that resistance may arise... | 18,710,918 |
Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle. | Continuous poleward movement of tubulin is a hallmark of metaphase spindle dynamics in higher eukaryotic cells and is essential for stable spindle architecture and reliable chromosome segregation. We use quantitative fluorescent speckle microscopy to map with high resolution the spatial organization of microtubule flux... | 18,710,922 |
The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. | Notch signaling plays a key role in various cell differentiation processes including bone homeostasis. However, the specific involvement of Notch in regulating osteoclastogenesis is still controversial. In the present study, we show that RANKL induces expression of Jagged1 and Notch2 in bone marrow macrophages during o... | 18,710,934 |
Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. | During pancreas development, transcription factors play critical roles in exocrine and endocrine differentiation. Transcriptional regulation in eukaryotes occurs within chromatin and is influenced by posttranslational histone modifications (e.g., acetylation) involving histone deacetylases (HDACs). Here, we show that H... | 18,710,955 |
Optimal electrocardiographic pulsing windows and heart rate: effect on image quality and radiation exposure at dual-source coronary CT angiography. | To determine the optimal width and timing of the electrocardiographic (ECG) pulsing window within the cardiac cycle in relation to heart rate (HR), image quality, and radiation exposure in patients who are suspected of having coronary artery disease. The institutional review board approved the study, and all patients g... | 18,710,975 |
Increasing carotid plaque echolucency is predictive of cardiovascular events in high-risk patients. | Carotid plaque echolucency seen at ultrasonography (US) is a potential indicator of plaque instability and may help identify patients at risk for major adverse cardiovascular events (MACEs). The authors performed this study to determine whether decreasing gray-scale median (GSM) levels at repeat carotid US examinations... | 18,710,994 |
Characterization and functional analyses of the human G protein-coupled receptor kinase 4 gene promoter. | The G protein-coupled receptor kinase 4 is involved in renal sodium handling and blood pressure regulation. Missense variants have already been tested functionally and are associated with hypertension, but no data on promoter analyses are yet available. We scanned 94 hypertensive white subjects for genetic variation an... | 18,711,008 |
Evaluating the degree of difficulty of laparoscopic colorectal surgery. | To quantify the degree of overall difficulty and the difficulty of each of the individual steps involved in the performance of laparoscopic colorectal procedures. The data should serve as a guide to surgeons in the early stages of their experience in laparoscopic colorectal surgery as to which procedures and steps to e... | 18,711,036 |
Comparison of Pediatric Voice Outcome Survey, Reflux Symptom Index, Reflux Finding Score, and esophageal biopsy results. | To examine correlations between the Pediatric Voice Outcome Survey (PVOS) score, the Reflux Symptom Index (RSI) score, the Reflux Finding Score (RFS), and esophageal biopsy findings in children undergoing upper aerodigestive tract endoscopy. Retrospective review of pediatric voice quality-of-life and laryngopharyngeal ... | 18,711,057 |
Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis. | SKG mice, a newly established model of rheumatoid arthritis (RA), spontaneously develop autoimmune arthritis accompanying extra-articular manifestations, such as interstitial pneumonitis. To examine possible roles of T cells for mediating this systemic autoimmunity, we generated T cell clones from arthritic joints of S... | 18,711,120 |
Case-control analysis of nucleotide excision repair pathway and the risk of renal cell carcinoma. | In this population-based case-control study with 325 Caucasian renal cell carcinoma (RCC) patients and 335 controls matched to cases by age, gender and county of residence, we evaluated the associations between 13 potential functional polymorphisms in nine major nucleotide excision repair (NER) genes and RCC risk. In i... | 18,711,149 |
The ADVANTAGE seeding trial: a review of internal documents. | Seeding trials, clinical studies conducted by pharmaceutical companies that are designed to seem as if they answer a scientific question but primarily fulfill marketing objectives, have not been described in detail. To describe a known seeding trial, ADVANTAGE (Assessment of Differences between Vioxx and Naproxen To As... | 18,711,155 |
Internal mammary nodes in breast cancer: diagnosis and implications for patient management -- a systematic review. | The management of internal mammary nodes (IMNs) in breast cancer is controversial. Surgical series from the 1950s showed that one third of breast cancer patients had IMN involvement, with a higher risk in patients with medial tumors and/or positive axillary nodes. IMN metastasis has similar prognostic importance as axi... | 18,711,171 |
Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer. | This study assessed the efficacy of the combination of standard taxane plus platinum chemotherapy with the synthetic Toll-like receptor 9-activating oligodeoxynucleotide PF-3512676 in patients with non-small-cell lung cancer (NSCLC). Chemotherapy-naive patients with stage IIIB to IV NSCLC were randomly assigned (one to... | 18,711,188 |
Structural and dynamic interfacial properties of the lipoprotein initiating domain of apolipoprotein B. | To better understand the earliest steps in the assembly of triglyceride (TG)-rich lipoproteins, we compared the biophysical and interfacial properties of two closely related apolipoprotein B (apoB) truncation mutants, one of which contains the complete lipoprotein initiating domain (apoB20.1; residues 1-912), and one o... | 18,711,207 |
Evaluation of pilot methadone maintenance therapy in Georgia (Caucasus). | Since December 2005 Methadone Treatment has been introduced in Georgia. Currently three programs are operating in the country covering 210 patients. The aim of this study was to assess the acceptability and effectiveness of the pilot methadone program. Case histories, registrations books, questionnaires were studied. S... | 18,711,233 |
A tandem calibration method for kerma-area product meters. | For measurements of the kerma-area product (KAP) in diagnostic x-ray imaging, a method for calibrating field KAP meters with a reference KAP meter is presented. In this tandem calibration method, the field KAP chamber is positioned similarly as in measurements with patients. The reference KAP chamber is placed at a spe... | 18,711,243 |
On the impact of longitudinal breathing motion randomness for tomotherapy delivery. | The purpose of this study is to explain the unplanned longitudinal dose modulations that appear in helical tomotherapy (HT) dose distributions in the presence of irregular patient breathing. This explanation is developed by the use of longitudinal (1D) simulations of mock and surrogate data and tested with a fully 4D H... | 18,711,250 |
Medical management of human immunodeficiency virus infection. | The human immunodeficiency virus (HIV)/ acquired immune deficiency syndrome (AIDS) pandemic has pervasive effects on culture, economics, policy, and human development. All organs can be affected by complications of HIV/AIDS, including the eye. When sufficient resources are available and widespread antiretroviral resist... | 18,711,266 |
An unusual variation in the anatomy of the uncinate process in external dacryocystorhinostomy. | Variations in the bony components of the nose are often encountered. One such variation was found in a 49-year-old male who had undergone conventional external dacryocystorhinostomy for adult onset nasolacrimal duct blockage. Intraoperatively, a thick bar of bone was seen beneath and parallel to the lacrimal sac fossa ... | 18,711,272 |
Effect of antiviral therapy on hepatitis C virus related glomerulopathy. | To determine the efficacy of antiviral therapy in hepatitis C virus associated glomerulopathy, we studied 30 patients with HCV-associated glomerulopathy at Sheikh Zayed Hospital, Lahore, Pakistan from June 2004 to February 2007. Membranoproliferative glomerulonephritis (MPGN) was the commonest kidney lesion, being repo... | 18,711,294 |
Network-based prediction of human tissue-specific metabolism. | Direct in vivo investigation of mammalian metabolism is complicated by the distinct metabolic functions of different tissues. We present a computational method that successfully describes the tissue specificity of human metabolism on a large scale. By integrating tissue-specific gene- and protein-expression data with a... | 18,711,341 |
Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. | Patients with inflammatory bowel disease (IBD) are at increased risk of developing colorectal adenocarcinoma. The factors that result in IBD-associated carcinogenesis are not understood. We hypothesized that altered expression of intestinal epithelial tight junction proteins might contribute to neoplastic progression. ... | 18,711,353 |
Industry funding and the reporting quality of large long-term weight loss trials. | Quality of reporting (QR) in industry-funded research is a concern of the scientific community. Greater scrutiny of industry-sponsored research reporting has been suggested, although differences in QR by sponsorship type have not been evaluated in weight loss interventions. To evaluate the association of funding source... | 18,711,388 |
Full-length hdmX transcripts decrease following genotoxic stress. | Previous studies have suggested that the mdmX gene is constitutively transcribed, and that MdmX protein activity is instead controlled by cellular localization and DNA damage induced Mdm2-mediated ubiquitination leading to proteasomal degradation. In these studies, we report that the human mdmX (hdmX) mRNA is reproduci... | 18,711,402 |
Critical pathways in cellular senescence and immortalization revealed by gene expression profiling. | Bypassing cellular senescence and becoming immortal is a prerequisite step in the tumorigenic transformation of a cell. It has long been known that loss of a key tumor suppressor gene, such as p53, is necessary, but not sufficient, for spontaneous cellular immortalization. Therefore, there must be additional mutations ... | 18,711,403 |
Simulating T-cell motility in the lymph node paracortex with a packed lattice geometry. | Agent-based simulation modelling of T-cell trafficking, activation and proliferation in the lymph node paracortex requires a model for cell motility. Such a model must be able to reproduce the observed random-walk behaviour of T cells, while accommodating large numbers of tightly packed cells, and must be computational... | 18,711,399 |
HIV and prostate cancer: a systematic review of the literature. | Malignancy occurs with increased frequency in the HIV-positive population. The true incidence of prostate cancer in this population is unknown. In the few cases that have been presented in the literature, prostate cancer in HIV-positive men appears to behave much like it does in HIV-negative men. Prostate cancer is the... | 18,711,409 |
What really happens to dendritic cells during malaria? | As dendritic cells (DCs) initiate all adaptive and some innate immune responses, it is not surprising that DC function during malaria is the subject of intensive investigations. However, the results of these investigations have so far been controversial. Here, we discuss various aspects of these studies, including the ... | 18,711,429 |
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. | Viral infection causes host cells to produce type I interferons (IFNs), which are critically involved in viral clearance. Previous studies have demonstrated that activation of the transcription factor interferon regulatory factor (IRF)3 is essential for virus-triggered induction of type I IFNs. Here we show that the E3... | 18,711,448 |
Tranexamic acid in the treatment of pediatric traumatic hyphema. | This study was undertaken to determine whether a difference exists in treatment outcome between patients treated with tranexamic acid (TEA) plus topical steroids and those treated with topical steroids alone. A retrospective cohort study was conducted to compare treatment results for children with traumatic hyphema tre... | 18,711,456 |
Repeatability of the multifocal visual evoked potentials in a clinical glaucoma setting. | To determine the reproducibility of the multifocal visual evoked potentials (mfVEP) test results in a clinical glaucoma setting, and the factors that affect variability. This was an observational case series study. The monocular mfVEP test, having a 58-sector, pattern-reversal dartboard array, was performed twice withi... | 18,711,458 |
Purcell effect in nonlinear photonic structures: a coupled mode theory analysis. | We develop a coupled mode theory (CMT) model of the behavior of a polarization source in a general photonic structure, and obtain an analytical expression for the resulting generated electric field; loss, gain and/or nonlinearities can also be modeled. Based on this treatment, we investigate the criteria needed to achi... | 18,711,488 |
Enhancement of optical Kerr effect in quantum-cascade lasers with multiple resonance levels. | In this paper, we investigated the optical Kerr lensing effect in quantum-cascade lasers with multiple resonance levels. The Kerr refractive index n2 is obtained through the third-order susceptibility at the fundamental frequency chi(3)( omega; omega, omega,-omega). Resonant two-photon processes are found to have almos... | 18,711,496 |
Dynamics of pump-induced refractive index changes in single-mode Yb-doped optical fibers. | We quantify the refractive index changes (RIC) in single-mode ytterbium-doped optical fibers induced by optical pulses at 980 nm and, for the first time, report details of the effect dynamics. The RIC dynamics is shown to follow that of the population of the excited/unexcited ion states with a factor proportional to th... | 18,711,503 |
Compact polymeric four-wavelength multiplexers based on cascaded step-size MMI for 1G/10G hybrid TDM-PON applications. | A novel polymeric four-wavelength multiplexer based on a new design concept of cascaded step-size multimode interferometer (CSS-MMI) is first presented. It can be fabricated by using planar lightwave circuit (PLC) technology and is highly compatible with both current 1-Gbps and future 10Gbps optical transceivers for ap... | 18,711,504 |
High quality quasi-Bessel beam generated by round-tip axicon. | We study theoretically and experimentally the spatial intensity distribution of the zero-order Bessel beam formed by the axicon which possess a rounded tip. Such a tip generates a refracted beam that interferes with the quasi-Bessel beam created behind the axicon. In turn an undesired intensity modulation occurs that s... | 18,711,507 |
Formation of superhydrophobic poly(dimethysiloxane) by ultrafast laser-induced surface modification. | The formation of hemispherical nanostructures and microscaled papilla by ultrafast laser irradiation was found to be a potential method to generate superhydrophbic surface of synthetic polymers. Irradiation of femtosecond laser creates roughened poly(dimethylsiloxane) (PDMS) surface in nano- and microscales, of which t... | 18,711,510 |
Intrinsic Raman spectroscopy for quantitative biological spectroscopy part II: experimental applications. | We demonstrate the effectiveness of intrinsic Raman spectroscopy (IRS) at reducing errors caused by absorption and scattering. Physical tissue models, solutions of varying absorption and scattering coefficients with known concentrations of Raman scatterers, are studied. We show significant improvement in prediction err... | 18,711,512 |
In vivo measurement of erythrocyte velocity and retinal blood flow using adaptive optics scanning laser ophthalmoscopy. | In vivo measurement of retinal blood flow is obtained by measuring the blood velocity of erythrocytes and lumen diameters of the blood vessels using an adaptive optics scanning laser ophthalmoscope. Erythrocyte velocity is measured by tracking erythrocytes moving across a horizontal scanning line. This approach provide... | 18,711,513 |
Fabrication of large-area patterned porous silicon distributed Bragg reflectors. | A process to fabricate porous silicon Bragg reflectors patterned on a micrometer lateral scale over wafer areas of several square centimeters is described. This process is based on a new type of projection system involving a megavolt accelerator and a quadrupole lens system to project a uniform distribution of MeV ions... | 18,711,514 |
Freeform LED lens for uniform illumination. | Light flux from LED must be redistributed to meet the needs of lighting in most cases, a new method is proposed for its secondary optic design. Based on refractive equation and energy conservation, a set of first-order partial differential equations which represent the characters of LED source and desired illumination ... | 18,711,534 |
Polarization-sensitive optical coherence tomography based on polarization-maintaining fibers and frequency multiplexing. | We report a novel polarization-maintaining fiber based optical coherence tomography for single detector imaging of tissue reflectivity and birefringence. A single depth scan yields quantitative birefringence information along the A-line accurately. Since the orthogonal polarization channels are frequency multiplexed, t... | 18,711,542 |
Gain and noise characteristics of high-bit-rate silicon parametric amplifiers. | We report a numerical investigation on parametric amplification of high-bit-rate signals and related noise figure inside silicon waveguides in the presence of two-photon absorption (TPA), TPA-induced free-carrier absorption, free-carrier-induced dispersion and linear loss. Different pump parameters are considered to ac... | 18,711,550 |
Pointing and tracking errors due to localized deformation in inter-satellite laser communication links. | Instead of Zernike polynomials, ellipse Gaussian model is proposed to represent localized wave-front deformation in researching pointing and tracking errors in inter-satellite laser communication links, which can simplify the calculation. It is shown that both pointing and tracking errors depend on the center deepness ... | 18,711,575 |
Bandgap formation and selective suppression of Bloch states in birefringent gyrotropic Bragg waveguides. | Birefringent magnetophotonic crystals are found to exhibit degeneracy breaking for asymmetric contradirectional coupling in planar waveguides. Fundamental to high-order local normal mode coupling leads to partially overlapping gyrotropic bandgaps inside the Brillouin zone and partial suppression of Bloch mode propagati... | 18,711,581 |
Paratyphoid blamed on Ulster: a nursing odyssey. | The aim of the Modicum mission from the United States was to determine the fate of the Western World, the Second Front and the Manhattan Project plans for development of atomic weapons. The Modicum mission was appointed in March 1942 by Franklin Delano Roosevelt as President and Commander-in-Chief of the US forces. The... | 18,711,624 |
Material and human resources for neonatal resuscitation in public maternity hospitals in Brazilian state capitals. | In 2002, the early neonatal mortality rate in Brazil was 12.42 per thousand live births. Perinatal asphyxia was the greatest cause of neonatal death (about 23%). This study aimed to evaluate the availability of the resources required for neonatal resuscitation in delivery rooms of public hospitals in Brazilian state ca... | 18,711,654 |
New sulphonamide and carboxamide derivatives of acyclic C-nucleosides of triazolo-thiadiazole and the thiadiazine analogues. Synthesis, anti-HIV, and antitumor activities. Part 2. | A new series of acyclic C-nucleosides 1',2'-O-isopropylidene-D-ribo-tetritol-1-yl)[1,2,4] triazolo[3,4-b][1,3,4]thiadiazoles bearing arylsulfonamide (5-8) and arylcarboxamide (9-12) residues have been synthesized under microwave irradiation. Thiadiazines 13-15 have been analogously prepared, and upon acid hydrolysis, a... | 18,711,666 |
Metalloregulation of triple helix formation by control of the loop conformation. | The flexible polypyridine ligand, 2,2':6',2('')-terpyridine (terpy), was built into the backbone of oligonucleotides to form DNA conjugates. The terpy unit functioned as a good loop when the conjugates formed the bimolecular triplexes with complementary oligopurine. The triplex structure was destabilized by the specifi... | 18,711,670 |
Differential expression of IGF-I and insulin receptor isoforms in HPV positive and negative human cervical cancer cell lines. | Human papillomavirus (HPV) is the main risk factor for cervical cancer; however, some carcinomas occur in the absence of the virus. IGF-IR and an isoform of the insulin receptor, IR-A, play important roles in cancer. In this study we assessed the role of the IGF/insulin receptors in cervical cancer cell lines with diff... | 18,711,691 |
Validation of quality indicators for radical prostatectomy. | The feasibility and validity of proposed radical prostatectomy quality indicators has not been well studied. We assessed indicator availability from treating charts. We tested the convergent construct validity of a modified subset that were available from this information source by correlating them to hospital prostate... | 18,711,699 |
Audiovisual integration during speech comprehension: an fMRI study comparing ROI-based and whole brain analyses. | Visual information (lip movements) significantly contributes to speech comprehension raising the question for the neural implementation of audiovisual (AV) integration during speech processing. To replicate and extend earlier neuroimaging findings, we compared two different analysis approaches in a slow event-related f... | 18,711,707 |
Attentional load modifies early activity in human primary visual cortex. | Recent theories of selective attention assume that the more attention is required by a task, the earlier are irrelevant stimuli filtered during perceptual processing. Previous functional MRI studies have demonstrated that primary visual cortex (V1) activation by peripheral distractors is reduced by higher task difficul... | 18,711,710 |
Conformational selection of protein kinase A revealed by flexible-ligand flexible-protein docking. | Protein kinases have high structural plasticity: their structure can change significantly, depending on what ligands are bound to them. Rigid-protein docking methods are not capable of describing such effects. Here, we present a new flexible-ligand flexible-protein docking model in which the protein can adopt conformat... | 18,711,718 |
Understanding the ring current effects on magnetic shielding of hydrogen and carbon nuclei in naphthalene and anthracene. | The local response to an external magnetic field normal to the molecular plane of naphthalene and anthracene was investigated via current density and magnetic shielding density maps. The Biot-Savart law shows that the deshielding caused by pi-ring currents in naphthalene is stronger for alpha- than for beta-protons due... | 18,711,723 |
Specific interaction between Sam68 and neuronal mRNAs: implication for the activity-dependent biosynthesis of elongation factor eEF1A. | In cultured hippocampal neurons and in adult brain, the splicing regulatory protein Sam68 is partially relocated to the somatodendritic domain and associates with dendritic polysomes. Transfer to the dendrites is activity-dependent. We have investigated the repertoire of neuronal mRNAs to which Sam68 binds in vivo. By ... | 18,711,726 |
Symptom combinations assessed in traditional Chinese medicine and its predictive role in ACR20 efficacy response in rheumatoid arthritis. | The predictive roles of symptom combination traditionally evaluated in traditional Chinese medicine (TCM) in the treatment of rheumatoid arthritis (RA) were explored. Three hundred and ninety six patients were randomly divided into 197 subjects receiving Western medicine therapy (WM) and 199 subjects receiving TCM ther... | 18,711,765 |
Green tea extract enhances the selective cytotoxic activity of Zizyphus jujuba extracts in HepG2 cells. | Anticarcinogenic effects attributed to phytochemicals may be based on synergistic, additive, or antagonistic interactions of many compounds. In our previous study, we demonstrated that the chloroform fraction (CHCl(3)-F) from Z. jujuba has anticancer activity in HepG2 cells. In China, many people drink jujuba tea and b... | 18,711,770 |
Active compounds isolated from traditional Chinese prescription Wen-Pi-Tang protecting against peroxynitrite-induced LLC-PK(1) cell damage. | Wen-Pi-Tang, a traditional Chinese prescription, has been widely used for the treatment of patients with moderate chronic renal failure in China. Although the protective effect of Wen-Pi-Tang on peroxynitrite (ONOO(-))-induced renal tubular epithelial LLC-PK(1) cell damage was elucidated in our previous research, the a... | 18,711,772 |
Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells. | Rhein, an anthraquinone derivative of rhubarb, inhibits the proliferation of various human cancer cells. In this paper, we focused on studying the effects of rhein on human hepatocelluar carcinoma BEL-7402 cells and further understanding the underlying molecular mechanism in an effort to make the potential development ... | 18,711,776 |
Mycobacterial tuberculous tenosynovitis of the extensor tendon occurring after liver transplantation: a case report. | Mycobacterial tuberculous tenosynovitis of the hand is a rare manifestation of extrapulmonary tuberculosis, while mycobacterial tuberculous tenosynovitis of the extensor tendon sheath is extremely rare. We report a case of tuberculous tenosynovitis of the extensor tendon of the finger, occurring in a man receiving immu... | 18,711,783 |
HIPAA Privacy Rule: 33,000 complaints, no fines. | The AOA Office of Counsel provides a review of recent reports, advisories, and court actions pertinent to the practice of eye and vision care. | 18,711,851 |
Risk factors affecting nutritional status of dialysis patients: a quality improvement project. | People with chronic kidney disease on dialysis are at very high risk for protein energy malnutrition (PEM). It is well documented that malnourished patients have increased frequency of hospital admissions, longer hospital stays, lower quality of life, and increased risk of death. Serum albumin level is a valid measure ... | 18,711,879 |
CROWNWeb: the evolution of kidney data management. 2. | The Centers for Medicare & Medicaid Services is developing a Web-based application, CROWNWeb, which is designed to update mandated electronic data entry and retrieval for dialysis facilities nationwide. Part 2 of this three-part series introduces CROWNWeb to the ESRD community. It discusses the release and impact o... | 18,711,883 |
[New challenges in forensic psychiatry]. | The new Swiss criminal code and the recent evolution of evaluation methods have led to change in the three main areas of forensic psychiatry: criminal responsibility, credibility of child sexual abuse allegations, and dangerousness. The assessment of criminal responsibility requires the retrospective examination of the... | 18,711,972 |
Larval tick infestation: a case report and review of tick-borne disease. | Tick-borne disease in the United States continues to be a threat as people interact with their natural surroundings. We present a case of an 8-year-old boy with a larval tick infestation. Ticks within the United States can carry Lyme disease, Rocky Mountain spotted fever (RMSF), ehrlichiosis, babesiosis, tularemia, tic... | 18,712,023 |
Plasma adiponectin is associated with plasma brain natriuretic peptide and cardiac function in healthy subjects. | The aim of this study was to evaluate the relationship between the plasma adiponectin level, plasma brain natriuretic peptide (BNP) level, and cardiac function in healthy subjects. We obtained clinical data and performed blood tests, including measurement of the plasma adiponectin and BNP levels, in 1,538 healthy perso... | 18,712,036 |
Pattern of 24-hour ambulatory blood pressure monitoring in type 2 diabetic patients with cardiovascular dysautonomy. | The pathophysiological mechanisms linking cardiovascular dysautonomy to mortality are unclear. The aim of this study was to investigate the pattern of 24-h ambulatory blood pressure (BP) monitoring (ABPM) in diabetic patients with cardiovascular autonomic neuropathy (CAN). We evaluated 391 type 2 diabetic patients in a... | 18,712,041 |
Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women. | Preeclampsia, a common complication of pregnancy, is characterized by elevated blood pressure and proteinuria developing after 20 weeks' gestational age. Susceptibility to this syndrome is believed to have a genetic component. The aim of this study was to investigate whether or not the 5,10-methylenetetrahydrofolate re... | 18,712,057 |
Attenuated increases in blood pressure by dynamic resistance exercise in middle-aged men. | The present study was performed to test the hypothesis that the blood pressure (BP) response to resistance exercise in middle-aged men with stiffening arteries is greater than that in young men with compliant arteries. The BP responses to acute dynamic resistance exercise (leg press) at individual relative (low, modera... | 18,712,060 |
[Influence of vitamin E application period on the mineral and D-vitamin metabolism in the organism]. | It was shown, that influence of vitamin E on mineral and D-vitamin metabolism depends on its doses and application period: physiological doses of vitamin E activate and large doses - inhibit the effect of vitamin D3 in regulation of mineral metabolism in the organism. The duration of application of large doses of vitam... | 18,712,117 |
[Treatment of chronic osteoarthritis pain: effectivity and safety of a 7 day matrix patch with a low dose buprenorphine]. | Patients with osteoarthritis often suffer from chronic pain. If pain treatment with NSAIDS and coxibes is no longer indicated, a constant and user friendly opioid analgesia can be achieved with a low dose buprenorphine patch being applicated using an interval of 7 days. The use of this matrix patch was evaluated in a m... | 18,712,130 |
Craniometric measurements of artificial cranial deformations in Eastern European skulls. | Standardized lateral cephalograms of eleven skulls with artificial cranial deformations from Eastern Europe and twenty normal skulls from the same population were made, digitized and imported into the AutoCAD 2005 computer program. The x- and y-coordinates of defined measuring points were determined and angle measureme... | 18,712,154 |
Regulation of matrix metalloproteinases (MMP)-2/-9 expression in eosinophilic chronic rhinosinusitis--cell culture by interleukin-5 and -13? | Eosinophils are a prominent immunological feature of chronic rhinosinusitis (CRS). Cytokines in the respiratory mucosa may be the key to upper airway pathophysiology. Matrix metalloproteinases (MMP) represent an entire group of Zn2+ dependent endopeptidases with the potential to alter the extracellular matrix (ECM). In... | 18,712,166 |
Corticosterone concentrations in blood and excretion in faeces after ACTH administration in male Sprague-Dawley rats. | The aim of the present study was to analyse the corticosterone response to exogenous ACTH in the circulation of catheterised male rats and to investigate the sensitivity of faecal corticosterone output as a measure of preceding elevated levels in the circulation. A total of 21 adult male Sprague-Dawley rats permanently... | 18,712,168 |
Interleukin-2 inhalation therapy in renal cell cancer: a case report and review of the literature. | Renal cell carcinoma (RCC) is the most common malignancy of the kidney. One third of RCC presents metastatic disease at the time of diagnosis, usually leading to a fatal outcome. Small response rates were seen with most cytotoxic agents including gemcitabine and vinorelbine, whereas systemic therapy with high doses of ... | 18,712,176 |
18F-FDG PET/CT in myeloma with presumed solitary plasmocytoma of bone. | To evaluate the value of 18F-fluorodeoxy-glucose (FDG) positron emission tomography with computed tomography (PET/CT) in myeloma in patients presenting with a solitary plasmacytoma of bone (SPB). Fourteen consecutive patients studied since 2006, all having a diagnosis of SPB before PET/CT imaging took part in this stud... | 18,712,181 |
Oral cavity awareness in nonnative speakers acquiring English. | This investigation assessed awareness of the oral cavity of nonnative speakers acquiring English. University students (60 men, 60 women) were placed into three equal-size groups. The Less Experienced group lived in the USA less than 6 mo. (M = 3.3 mo., SD = 2.4). The More Experienced group lived in the United States 3 ... | 18,712,203 |
Person-centered support and athletes' motivation for performance. | The purpose of the study was to examine the effect of person-centered intervention on motivation for athletic performance. 74 volleyball players, 24 boys and 50 girls (M age = 13 yr., SD = 1.0), completed a motivation questionnaire, the Leistungs Motivations Test für Jugendlichen prior to and after an 8-mo. group treat... | 18,712,207 |
The role of dietary calcium concentration in the use of anionic salts to prevent parturient paresis in dairy cows. | The role of dietary calcium concentration during the feeding of anionic salts (AS) was reviewed. Hypocalcaemia is still the major cause of parturient paresis in dairy cows. Feeding AS is an established method for preventing severe hypocalcaemia by activating the calcium metabolism in the last two to three weeks before ... | 18,712,261 |
[Mycobacterium gordonae as potential cause of granulomatous lesions of the toe tips in the South African clawed frog (Xenopus laevis)]. | During regular health status monitoring of the colony of amphibian, Mycobacterium (M.) gordonae were isolated from granulomatous lesions of the tiptoes from the South African clawed frog (Xenopus laevis) maintained at the Tierforschungszentrum of the University of Ulm. During a period of three years a total of 21 anima... | 18,712,263 |
Structural biology of the purine biosynthetic pathway. | Purine biosynthesis requires ten enzymatic transformations to generate inosine monophosphate. PurF, PurD, PurL, PurM, PurC, and PurB are common to all pathways, while PurN or PurT, PurK/PurE-I or PurE-II, PurH or PurP, and PurJ or PurO catalyze the same steps in different organisms. X-ray crystal structures are availab... | 18,712,276 |
Hormone induced changes in lactase glycosylation in developing rat intestine. | Lactase exists in both soluble and membrane-bound forms in suckling rat intestine. The distribution of lactase and its glycosylated isoforms in response to thyroxine or cortisone administration has been studied in suckling rats. 75% of lactase activity was detected, associated with brush borders, compared to 24% in the... | 18,712,286 |
An introduction to protein contact prediction. | A fundamental problem in molecular biology is the prediction of the three-dimensional structure of a protein from its amino acid sequence. However, molecular modeling to find the structure is at present intractable and is likely to remain so for some time, hence intermediate steps such as predicting which residues pair... | 18,712,298 |
Inferring function from homology. | Modern molecular biology approaches often result in the accumulation of abundant biological sequence data. Ideally, the function of individual proteins predicted using such data would be determined experimentally. However, if a gene of interest has no predictable function or if the amount of data is too large to experi... | 18,712,301 |
Phylogenetic shadowing: sequence comparisons of multiple primate species. | Comparisons between the sequence of the human genome and that of species at a variety of evolutionary distances from human have emerged as one of the most powerful strategies for identifying the functional coding and non-coding elements in the genome. Although the analysis of traits shared between human and distant rel... | 18,712,305 |
Visualization. | Visualization is a powerful method to present and analyze a large amount of data. It is increasingly important in bioinformatics and is used for exploring different types of molecular biological data, such as structural information, high throughput data, and biochemical networks. This chapter gives a brief introduction... | 18,712,318 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.