title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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[Possibilities and limits for treating psoriasis with biologics. Case reports]. | The availability of biologics for the therapy of psoriasis has radically changed the options for systemic therapy of this disease. Their use is often coupled with a variety of restrictions--as a rule they are to be used as a 'last-line' therapy. The status of previous systemic therapy as a basic requirement for the use... | 18,712,323 |
Divergent evolution of feeding substrate preferences in a phylogenetically young species flock of pupfish (Cyprinodon spp.). | A fundamental question in sympatric speciation is how trophic divergence is achieved. We used an extremely young (<8,000 years) species flock of pupfish (Cyprinodon spp.) from Laguna Chichancanab in south-eastern Mexico to examine divergent evolution of preferences for different feeding substrates. In a test aquariu... | 18,712,336 |
Lateral ankle fracture with missed proximal tibiofibular joint instability (Maisonneuve injury). | We present a case of a soccer player who sustained a lateral ankle fracture and the associated proximal anterolateral tibiofibular joint instability (Maisonneuve injury) was overlooked. After a non-contact injury the (incomplete) diagnosis of a lateral malleolar fracture (type Weber B, AO 44-B1) was made and the patien... | 18,712,356 |
The correlation of correction magnitude and tibial slope changes following open wedge high tibial osteotomy. | We investigated whether there is a correlation between coronal plane correction magnitude and tibial slope in patients treated with medial open wedge high tibial osteotomy (OWHTO) and also measured changes in patellar height. Thirty-four knees treated with for varus deformities were retrospectively reviewed and the fol... | 18,712,358 |
Early preclinical studies of discriminable sedative and hallucinogenic drug effects. | One important technique in behavioral pharmacology is to train laboratory animals to discriminate between a psychoactive drug effect and a nondrug condition. Tests with different drugs have identified several categories of drugs that have different discriminable effects. The two authors describe and discuss the early r... | 18,712,362 |
Grasp cueing and joint attention. | We studied how two different hand posture cues affect joint attention in normal observers. Visual targets appeared over lateralized objects, with different delays after centrally presented hand postures. Attention was cued by either hand direction or the congruency between hand aperture and object size. Participants pr... | 18,712,369 |
Reflexive and volitional voice fundamental frequency responses to an anticipated feedback pitch error. | The pitch-shift reflex is a corrective voice fundamental frequency (F0) response triggered by a sudden shift or "error" in auditory feedback pitch. We investigated how anticipating a voice pitch error affects the pitch-shift reflex and volitional voice F0 responses. Adults sustained the vowel/u/at a comfortable pitch a... | 18,712,372 |
Radiological features of ingested metallic mesh earphone pieces. | Foreign body ingestion remains a frequent cause of morbidity in infants and children. Symptoms vary with size, shape, location and composition of the foreign body. Flat objects tend to rotate to the greatest diameter of the esophageal lumen and become oriented in the coronal plane. We report two cases of ingested metal... | 18,712,380 |
Comparison of distal and proximal centralising devices in hip arthroplasty. | Centralising devices were introduced to ensure that the prosthesis is implanted in a neutral position and that a cement mantle of optimal thickness is achieved proximally and distally. A distal centralising device (DCD) is compared with a proximal midshaft centralising device (PCD) to test which one provides a more neu... | 18,712,387 |
[Clonal association of flat epithelial atypia and tubular breast cancer]. | Flat epithelial atypia (FEA) of the breast has recently gained attention as a possible precursor lesion of highly differentiated breast cancer. Especially tubular carcinomas, with which FEA shares cytological features, often occur in close proximity to each other. To examine a possible clonal relationship, we analysed ... | 18,712,391 |
Ischiogluteal bursitis: a report of three cases with MR findings. | Ischiogluteal bursitis is an uncommon disorder which can be confused with neoplastic conditions in the buttock. Three cases of ischiogluteal bursitis in a 57-year-old man, a 73-year-old woman and a 73-year-old man are presented. All patients presented with a gradually increasing, painful buttock mass. Magnetic resonanc... | 18,712,394 |
Migration of hip revision stems into the knee joint: alternative treatment modalities: technical note. | We report two unusual cases of stem penetration of long shaft femoral prosthesis into the knee joint after revision total hip arthroplasty. In both patients, the protruded tip of the stem interfered with the tibial plateau and averted the knee joint from full range of motion. To avoid further extensive surgery, the tip... | 18,712,403 |
Vertical whole-body vibration does not increase cardiovascular stress to static semi-squat exercise. | The purpose of this study was to determine the effect of vertical whole-body vibration (WBV) on heart rate (HR), mean arterial pressure (MAP), femoral artery blood flow (FBF), and leg skin temperature (LSk(temp)) during static exercise. These parameters were examined: seated next to the WBV device (passive, unloaded), ... | 18,712,407 |
Mechanical spinal cord compression at the apex of a kyphosis: a propos of one case. Review of the literature. | There are a few case reports in the literature on mechanical compressions of the spinal cord associated with Scheuermann's disease and the treatment is not codified. We describe a case of spinal cord compression at the apex of the kyphosis, which disappeared with the reduction of the deformity. Given the skeletal immat... | 18,712,418 |
Coordination and binding geometry of methyl-coenzyme M in the red1m state of methyl-coenzyme M reductase. | Methane formation in methanogenic Archaea is catalyzed by methyl-coenzyme M reductase (MCR) and takes place via the reduction of methyl-coenzyme M (CH3-S-CoM) with coenzyme B (HS-CoB) to methane and the heterodisulfide CoM-S-S-CoB. MCR harbors the nickel porphyrinoid coenzyme F430 as a prosthetic group, which has to be... | 18,712,421 |
Microbial community dynamics in uranium contaminated subsurface sediments under biostimulated conditions with high nitrate and nickel pressure. | The subsurface at the Oak Ridge Field Research Center represents an extreme and diverse geochemical environment that places different stresses on the endogenous microbial communities, including low pH, elevated nitrate concentrations, and the occurrence of heavy metals and radionuclides, including hexavalent uranium [U... | 18,712,423 |
Short-term effects of high-dose zoledronic acid treatment on bone mineralization density distribution after orthotopic liver transplantation. | Patients with "hepatic" bone disease exhibit increased fracture incidence. The effects on bone material properties, their changes due to orthotopic liver transplantation (OLT), as well as zolendronate (ZOL) treatment have not yet been investigated. We studied bone mineralization density distribution (BMDD) in paired tr... | 18,712,431 |
Teaching the "hybrid approach": a novel swine model of muscular ventricular septal defect. | This report describes a reproducible swine model for creating muscular ventricular septal defects (VSDs). The model not only facilitates the development and modification of hybrid techniques for closing muscular VSDs, but also serves as a teaching tool that allows operators to become accustomed to the specific technica... | 18,712,433 |
Age-, race-, and ethnicity-related differences in the treatment of nonmetastatic rectal cancer: a patterns of care study from the national cancer data base. | Recent studies suggest that older patients and minorities are less likely to receive surgical and adjuvant therapy for rectal cancer. We analyzed the independent effect of age and race/ethnicity on treatment for rectal cancer controlling for comorbidity and socioeconomic status using a nationwide sample We identified 3... | 18,712,449 |
Quality of life evaluated by Short Form-8 in patients with rheumatoid arthritis who were receiving infusion of infliximab. | In this study, influences of infliximab to health-related quality of life (HRQOL) and active status of RA were assessed. Between 2003 and 2006, 22 patients with rheumatoid arthritis (RA) began receiving infusion of infliximab. Of all the patients, 17 patients who were followed for at least 30 weeks (102 weeks at maximu... | 18,712,459 |
Body image satisfaction in heterosexual, gay, and lesbian adults. | Does the prevalence and degree of body dissatisfaction differ among heterosexual and homosexual men and women? Some theorists have suggested that, compared to their heterosexual peers, gay men are at greater risk for body dissatisfaction and lesbians at lower risk. Past studies examining this issue have generally relie... | 18,712,469 |
Complementary and alternative therapies among very long-term breast cancer survivors. | Breast cancer patients may have different complementary and alternative medicine (CAM) usage rates and may turn to CAM for different reasons than healthy adults. CAM has mostly been studied in recently diagnosed women; no studies have included survivors 10 years post-diagnosis. We examined very long-term breast cancer ... | 18,712,472 |
Weighted analyses for cohort sampling designs. | Weighted analysis methods are considered for cohort sampling designs that allow subsampling of both cases and non-cases, but with cases generally sampled more intensively. The methods fit into the general framework for the analysis of survey sampling designs considered by Lin (Biometrika 87:37-47, 2000). Details are gi... | 18,712,477 |
Autonomic dysfunctions in patients with inflammatory bowel disease in clinical remission. | The autonomic nervous system, especially the parasympathetic system, has been reported to modulate the immune response in chronic inflammatory disorders. Autonomic dysfunctions have been reported earlier in patients with inflammatory bowel disease; however, the results have been conflicting. We therefore evaluated auto... | 18,712,478 |
Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820. | The aim of this study was to assess the population pharmacokinetics (PopPK) of the novel oral anti-cancer agent E7820. Both a non-linear mixed effects modeling analysis and a non-compartmental analysis (NCA) were performed and results were compared. Data were obtained from a phase I dose escalation study in patients wi... | 18,712,503 |
Production of ethanol by filamentous and yeast-like forms of Mucor indicus from fructose, glucose, sucrose, and molasses. | The fungus Mucor indicus is found in this study able to consume glucose and fructose, but not sucrose in fermentation of sugarcane and sugar beet molasses. This might be an advantage in industries which want to selectively remove glucose and fructose for crystallisation of sucrose present in the molasses. On the other ... | 18,712,551 |
Evaluation of the white-rot fungi Ganoderma australe and Ceriporiopsis subvermispora in biotechnological applications. | Ganoderma australe is a white-rot fungus that causes a selective wood biodelignification in some hardwoods found in the Chilean rainforest. Ceriporiopsis subvermispora is also a lignin-degrading fungus used in several biopulping studies. The enzymatic system responsible for lignin degradation in wood can also be used t... | 18,712,558 |
Biosurfactant production by free and alginate entrapped cells of Pseudomonas fluorescens. | Production of biosurfactant by free and alginate-entrapped cells of Pseudomonas fluorescens Migula 1895-DSMZ was investigated using olive oil as the sole carbon and energy source. Biosurfactant synthesis was followed by measuring surface tension and emulsifying index E24 over 5 days at ambient temperature and at neutra... | 18,712,561 |
Pharmacologic effects of grain weevil extract on isolated guinea pig tracheal smooth muscle. | The grain weevil, an insect (pest) that infects grain, is a frequent contaminant of processed wheat, and its presence may contribute to respiratory abnormalities in grain workers. We studied the in vitro effects of an extract of grain weevil (GWE) on airway smooth muscle. Pharmacologic studies included in vitro challen... | 18,712,564 |
Vitamin E in human health and disease. | Vitamin E in nature is comprised of a family of tocopherols and tocotrienols. The most studied of these is alpha-tocopherol (alpha-TOH), because this form is retained within the body, and vitamin E deficiency is corrected with this supplement. alpha-TOH is a lipid-soluble antioxidant required for the preservation of ce... | 18,712,629 |
One lesson from arthroplasty to osseointegration in search for better fixation of in-bone implanted prosthesis. | Direct transcutaneous prosthetic attachment (osseointegration) consists of implanting directly into the residuum bone a metal pylon whose external fraction connects the residuum to the external prosthesis. Since the introduction of osseointegration about 20 years ago, the obvious challenge associated with this technolo... | 18,712,634 |
Acute mountain sickness in disability and adaptive sports: preliminary data. | Acute mountain sickness (AMS) is a frequent complication for military personnel, veterans, athletes, and travelers at high altitudes. Symptoms may occur in individuals with less cerebrospinal fluid volume and less ability to accommodate increased brain volume. No studies on AMS exist in individuals with neurological im... | 18,712,635 |
Distributed cognitive aid with scheduling and interactive task guidance. | A cognitive assistive technology system has been designed for use by people with memory and organizational impairments. This system will provide a distributed architecture for both scheduling assistance and task guidance, as well as intelligent, automatic replanning on the levels of both the schedule and individual tas... | 18,712,637 |
Electroacupuncture may help motor recovery in chronic stroke survivors: a pilot study. | Past studies have suggested that acupuncture may reduce spasticity in stroke survivors. We do not know, however, whether acupuncture may enhance the effect of strength training on motor function. This study compared upper-limb motor functional improvement in chronic stroke survivors who received a combination of acupun... | 18,712,644 |
Accuracy of uniaxial accelerometer in chronic obstructive pulmonary disease. | Wearable sensors have been developed and used in nondisabled adults. Little is known about their accuracy in patients with chronic disease. We tested the ActiHealth accelerometer, which measures step counts, in subjects with chronic obstructive pulmonary disease (COPD). We determined the intra- and interdevice coeffici... | 18,712,646 |
Effective methods of pelvic plexus nerve and bladder stimulation in anesthetized animal model. | Urinary retention is a serious urological problem associated with spinal cord injuries (SCIs) and other pelvic disorders. Effective methods of pelvic nerve stimulation were investigated for this problem. Following anesthesia in five dogs, the bladder was surgically exposed. Bladder and anal sphincter pressures were rec... | 18,712,648 |
A 24-hour feasibility study of intraurethral valved catheter for bladder management in males with spinal cord injury. | This feasibility study was conducted to evaluate design features of the novel intraurethral valved catheter, Surinate (Urovalve, Inc; Newark, New Jersey). The device extends from the bladder neck to just beyond the external sphincter and contains a valve that can be activated by an external magnet for bladder emptying.... | 18,712,649 |
[Asteroid hyalosis within an epiretinal membrane]. | In May 2007 an 80-year-old man with a known proliferative diabetic retinopathy presented in our outpatient department with a decrease in visual acuity of his right eye. There was a thick asteroid hyalosis preventing fundus examination. Sonographically, there were vitreoretinal tractions requiring a vitrectomy. During s... | 18,712,661 |
Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma. | The retinoblastoma protein-interacting zinc finger gene RIZ1 is a putative tumor suppressor gene, and the inactivation of the RIZ1 is frequently found in tumors through a loss of mRNA expression. In order to understand the role of RIZ1 inactivation in the tumorigenesis of hepatocellular carcinoma (HCC), we detected the... | 18,712,668 |
Treatment with tacrolimus enhances alveolar bone formation and decreases osteoclast number in the maxillae: a histomorphometric and ultrastructural study in rats. | Recent studies have suggested that tacrolimus monotherapy is a beneficial therapeutic alternative for the normalization of cyclosporin-induced bone loss in animal models and humans. The mechanism accounting for this action is unclear at present. In the present study, we attempted to determine the effect of tacrolimus m... | 18,712,669 |
Reg I protein in healthy and seminoma human testis. | Regenerating gene (Reg), encodes a secretory protein with growth and differentiation stimulating effects mostly in digestive tissues. Overexpression of Reg proteins and specifically of Reg I, one member of the Reg family, is associated with several human diseases and cancers. In the present study we analyzed the expres... | 18,712,671 |
Personality changes and the role of counseling in the rehabilitation of patients with laryngeal cancer. | We conducted a study of 65 adults who had undergone laryngectomy for the treatment of laryngeal cancer. Our goal was to identify any abnormal personality traits in these patients and to assess the effect that psychological counseling might have on correcting these abnormalities and thereby improving postoperative voice... | 18,712,685 |
Medicinal organometallic chemistry: designing metal arene complexes as anticancer agents. | The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functional... | 18,712,745 |
Protein and peptides in pictures: imaging with MALDI mass spectrometry. | Imaging using MS has the potential to deliver highly parallel, multiplexed data on the specific localization of molecular ions in tissue samples directly, and to measure and map the variations of these ions during development and disease progression or treatment. There is an intrinsic potential to be able to identify t... | 18,712,772 |
Testing linkage disequilibrium from pooled DNA: a contingency table perspective. | Pooling DNA samples of multiple individuals has been advocated as a method to reduce genotyping costs. Under such a scheme, only the allele counts at each locus, not the haplotype information, are observed. We develop a systematic way for handling such data by formulating the problem in terms of contingency tables, whe... | 18,712,782 |
Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation. | The identification of the hepatitis C virus (HCV) strain JFH-1 enabled the successful development of infectious cell culture systems. Although this strain replicates efficiently and produces infectious virus in cell culture, the replication capacity and pathogenesis in vivo are still undefined. To assess the in vivo ph... | 18,712,792 |
Development of an asset map of medical education research activity. | Medical education research is gaining recognition as scholarship within academic medical centers. This survey was conducted at a medium-sized academic medical center in the United States. The purpose of the study was to learn faculty interest in research in medical education, so assets could be used to develop educatio... | 18,712,796 |
Social interaction and participation: formative evaluation of online CME modules. | This exploratory study examines Canadian physicians' participation in online social activities and learning discussions, perceptions of online social closeness, barriers and motivators to participation, and perceptions of the impact of course duration and face-to-face meetings on learning. Formative evaluations were ad... | 18,712,801 |
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists. | Replacing the conventional pyrazole 5-aryl substituent of 1 (SR141716A) with the 2-thienyl moiety appended with an appropriate alkynyl unit, a novel class of 5-(5-alkynyl-2-thienyl)pyrazole derivatives, behaving as highly potent CB1 receptor antagonists with good CB1/2 selectivity, was discovered, many of which, as typ... | 18,712,856 |
Nitroxide paramagnet-induced para-ortho conversion and nuclear spin relaxation of H2 in organic solvents. | The kinetics of para-ortho conversion and nuclear spin relaxation of H 2 in chloroform- d 1 were investigated in the presence of nitroxides as paramagnetic catalysts. The back conversion from para-hydrogen ( p-H 2) to ortho-hydrogen ( o-H 2) was followed by NMR by recording the increase in the intensity of the signal o... | 18,712,869 |
Transition from complete to partial wetting within membrane compartments. | Wetting and dewetting phenomena are ubiquitous, but wetting transitions have been reported only in a few experimental systems. In this work, we present a wetting transition in a mesoscopic membrane compartment for the first time. A two-phase aqueous polymer solution was encapsulated in a giant vesicle (few tens of micr... | 18,712,871 |
Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide. | Human O(6)-alkylguanine-DNA alkyltransferase (hAGT) expression increases mutations and cytotoxicity following exposure to 1,3-butadiene diepoxide (BDO), and hAGT-DNA cross-links are formed in the presence of BDO. We have used hAGT mutants to investigate the mechanism of cross-link formation and genotoxicity. Formation ... | 18,712,882 |
Streaming potential generated by a long viscous drop in a capillary. | The streaming potential generated by motion of a long drop of viscosity mu(d) = lambdamu in a uniform circular capillary filled with fluid of viscosity mu is investigated by means of a model previously used to study electrophoresis of a charged mercury drop in water. The capillary wall is at potential zeta c relative t... | 18,712,893 |
Evaluation of the pharmacokinetic effects of various linking group using the 111In-DOTA-X-BBN(7-14)NH2 structural paradigm in a prostate cancer model. | The high incidence of BB2 receptor (BB2r) expression in various cancers has prompted investigators to pursue the development of BB2r-targeted agents for diagnostic imaging, chemotherapy, and radiotherapy. Development of BB2r-targeted agents, based on the bombesin (BBN) peptide, has largely involved the use of the bifun... | 18,712,899 |
closo-borane conjugated regulatory peptides retain high biological affinity: synthesis of closo-borane conjugated Tyr(3)-octreotate derivatives for BNCT. | Despite the improvements in cancer therapy during the past years, high-grade gliomas and many other types of cancer are still extremely resistant to current forms of therapy. Boron neutron capture therapy (BNCT) provides a promising way to destroy cancer cells without damaging healthy tissue. However, BNCT in practice ... | 18,712,900 |
Atomistic insights into the inhibition of cysteine proteases: first QM/MM calculations clarifying the stereoselectivity of epoxide-based inhibitors. | Due to their important role in many diseases, cysteine proteases represent new promising drug targets. An important class of cysteine-protease inhibitors is derived from the naturally occurring compound E64, possessing an epoxysuccinyl moiety as warhead. Experimental studies show stereoselectivity concerning the inhibi... | 18,712,902 |
Comparisons of multilayer H2O adsorption onto the (110) surfaces of alpha-TiO2 and SnO2 as calculated with density functional theory. | Mono- and bilayer adsorption of H2O molecules on TiO2 and SnO 2 (110) surfaces has been investigated using static planewave density functional theory (PW DFT) simulations. Potential energies and structures were calculated for the associative, mixed, and dissociative adsorption states. The DOS of the bare and hydrated s... | 18,712,914 |
Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats. | Studies were undertaken to determine whether bovine lactoferrin (bLF) and related compounds, shown to prevent carcinogenesis in the colon and other organs in rats, have any toxic effects in long-term feeding studies. In experiment I, male F344/DuCrj rats received a basal diet containing 0.2% bLF for 40 weeks. No advers... | 18,712,982 |
Cleaved SLPI, a novel biomarker of chymase activity. | Secretory leukocyte protease inhibitor (SLPI) is a protease inhibitor of the whey acidic protein-like family inhibiting chymase, chymotrypsin, elastase, proteinase 3, cathepsin G and tryptase. Performing in vitro enzymatic assays using both Western blotting and liquid chromatography/mass spectrometry techniques we show... | 18,713,008 |
Cytotoxic and peptidase inhibitory activities of selected non-hepatotoxic cyclic peptides from cyanobacteria. | Toxic cyanobacterial blooms are a rich source of metabolites having a variety of biological activities. Two main groups of cyclic peptides, depsipeptides and ureido linkage-containing peptides, reportedly inhibit serine peptidases. We characterised their inhibitory properties against selected peptidases and investigate... | 18,713,022 |
Infinite models in scoliosis: a review of the literature and analysis of personal experience. | The purpose of this study was to introduce infinite models in scoliosis and to analyze personal experience. Based on a three-dimensional patient-specific finite element model of the spine, rib cage, pelvis and abdomen, a parametric individual model of a thoracolumbosacral orthosis was built. Three standard strap tensio... | 18,713,029 |
Methods and tools for comparative genomics of foodborne pathogens. | A comparison of genome sequences and of encoded proteins with the database of existing annotated sequences is a useful approach to understand the information at the genome level. Here we demonstrate the utility of several DNA and protein sequence comparison tools to interpret the information obtained from several genom... | 18,713,064 |
Human hair pigmentation--biological aspects. | Skin and hair colour contribute significantly to our overall visual appearance and to social/sexual communication. Despite their shared origins in the embryologic neural crest, the hair follicle and epidermal pigmentary units occupy distinct, although open, cutaneous compartments. They can be distinguished principally ... | 18,713,071 |
Irritancy ranking of 31 cleansers in the Indian market in a 24-h patch test. | Cleansing trends promise freshness, sensory and health benefits but may also be accompanied by an increase in soap-induced skin irritation. The aim of this study was to evaluate the irritant effect of 31 cleansers (28 bar soaps and 3 liquid cleansers) available in the Indian market. Eight percent w/v solutions of the s... | 18,713,074 |
The efficacy and applicability of a pulmonary rehabilitation programme for patients with COPD in a secondary-care community hospital. | Pulmonary rehabilitation is known to have beneficial effects in COPD patients. This study aimed to assess the applicability and efficacy of a pulmonary rehabilitation programme in a community hospital lacking specialist pulmonary rehabilitation services. This randomized, controlled, prospective study included a total o... | 18,713,091 |
Comparison of severity scoring systems A-DROP and CURB-65 for community-acquired pneumonia. | The initial assessment of the severity of community-acquired pneumonia (CAP) is important for patient management. The Japanese Respiratory Society (JRS) has proposed a 6-point scale (0-5) to assess the clinical severity of CAP. The A-DROP scoring system assesses the following parameters: (i) Age (male >or= 70 years,... | 18,713,094 |
Primary pulmonary synovial sarcoma, a rare primary lung neoplasm: two case reports and review of the current literature. | This report describes the clinical, histological and immunohistochemical features of two patients with primary pulmonary synovial sarcoma in the context of the literature. Chest pain, cough, haemoptysis and an enlarging pleural-based mass are the main clinical manifestations. Diagnosis depends on identifying epithelioi... | 18,713,096 |
Minimization protocols in pancreas transplantation. | Diagnosis of immunologic injury (acute and chronic) is much more difficult in pancreas transplants when compared with transplants of other organs. Currently, the immunosuppressive regimen for induction involves calcineurin inhibitors (CNI), antimetabolites and corticosteroids (Cs). This strong and nonspecific regimen d... | 18,713,147 |
Determinants of work among older adults in urban China. | We examined the role of personal, family and institutional factors on the work status of older adults in urban China. The analysis was based on data from a large population survey (N = 7381) of community-dwelling urban Chinese aged 60 years and older. Multivariate logistic regression was used to model work status. Demo... | 18,713,172 |
Dementia severity and on-road assessment: briefly revisited. | Drivers with dementia should cease driving if unsafe. This report aims to add to the evidence concerning use of global dementia severity as an indicator of driving performance. One hundred and fifteen drivers were assessed via standardised on-road assessment. Descriptive and comparative statistics analysed age and glob... | 18,713,176 |
Measuring disability in older adults: the International Classification System of Functioning, Disability and Health (ICF) framework. | Despite the importance of disability to geriatric medicine, no large scale study has validated the activity and participation domains of the International Classification System of Functioning, Disability, and Health (ICF) in older adults. The current project was designed to conduct such as analysis, and then to examine... | 18,713,189 |
The aged care pain chart: an innovative approach to assessing, managing and documenting pain in older people. | This article presents the development and initial testing of a comprehensive pain chart for the assessment, management and documentation of pain in older people in subacute and residential aged care. The pain chart was developed from existing assessment scales and pain indicators, and is targeting needs of older people... | 18,713,200 |
Physiologically motivated time-delay model to account for mechanisms underlying enterohepatic circulation of piroxicam in human beings. | The study was conducted to formulate a physiologically motivated time-delay (PM TD) mathematical model for human beings, which incorporates disintegration of a drug formulation, dissolution, discontinuous gastric emptying and enterohepatic circulation (EHC) of a drug. Piroxicam, administered to 24 European, healthy ind... | 18,713,233 |
The oxidation handicap hypothesis and the carotenoid allocation trade-off. | The oxidation handicap hypothesis proposes that testosterone mediates the trade-off between the expression of secondary sexual traits and the fight against free radicals. Coloured traits controlled by testosterone can be produced by carotenoid pigments (yellow-orange-red traits), but carotenoids also help to quench fre... | 18,713,241 |
Evolution of grasping among anthropoids. | The prevailing hypothesis about grasping in primates stipulates an evolution from power towards precision grips in hominids. The evolution of grasping is far more complex, as shown by analysis of new morphometric and behavioural data. The latter concern the modes of food grasping in 11 species (one platyrrhine, nine ca... | 18,713,244 |
Clinical outcome of moderate haemophilia compared with severe and mild haemophilia. | Information on outcome and treatment of patients with moderate haemophilia is scarce. In this study, we compared self-reported burden of disease in moderate haemophilia to severe and mild haemophilia. A nationwide questionnaire on bleeding pattern, treatment, impairment and quality of life was sent to 1567 Dutch patien... | 18,713,246 |
Urinary tract reconstruction using the controlateral native ureter and a combined open-retroperitoneoscopic approach after renal transplantation. | An alternative technique for urinary tract (UT) reconstruction is described in a renal transplant recipient who developed a severe stenosis of the graft ureter. This approach entails the retroperitoneoscopic preparation of the native ureter contralateral to the graft, followed by an open reconstruction of the UT. The u... | 18,713,262 |
Intracutaneous injection of the macrophage-activating lipopeptide-2 (MALP-2) which accelerates wound healing in mice--a phase I trial in 12 patients. | Chronic skin ulcers, such as leg ulcers, pressure sores and diabetic foot ulcers, are a challenge to physicians and medical personnel and a cause of tremendous discomfort and ensuing loss of quality of life to the patients. Wound healing involves production and action of various growth factors. A novel approach, distin... | 18,713,273 |
Effect of porto-systemic shunting on NOS expression after extended hepatectomy in rats. | Several surgical procedures have been developed for reducing portal vein pressure to prevent postoperative liver injury. Nitric oxide synthase expression (NOS) induced by elevation of portal vein pressure is thought to play an important role in liver regeneration, but the details are not well understood. Rats in the co... | 18,713,274 |
Lysogeny in Lactobacillus delbrueckii strains and characterization of two new temperate prolate-headed bacteriophages. | Frequency of lysogeny in Lactobacillus delbrueckii strains (from commercial and natural starters) and preliminary characterization of temperate bacteriophages isolated from them. Induction of strains (a total of 16) was made using mitomycin C (MC) (0.5 mug ml(-1)). For 37% of the MC-treated supernatants, it was possibl... | 18,713,281 |
A citrate-inducible gene, encoding a putative tricarboxylate transporter, is downregulated by the organic solvent DMSO in Agrobacterium tumefaciens. | To investigate the effects of the organic solvent dimethyl sulfoxide (DMSO) on the expression of a citrate-inducible gene, encoding a putative tricarboxylate transporter, in Agrobacterium tumefaciens. By two-dimensional gel electrophoresis, we discovered a putative tricarboxylate transporter named ActC, whose expressio... | 18,713,283 |
Algorithm-based design of synthetic growth media stimulating virulence properties of Metarhizium anisopliae conidia. | Synthetic media should be designed for the production of Metarhizium anisopliae conidia with improved virulence properties. A genetic algorithm (GA), demonstrated to be suitable for the design of media for spore mass production (Hutwimmer et al. 2008), was utilized for a multi-objective medium design to improve conidia... | 18,713,285 |
Long-term results of balloon-occluded retrograde transvenous obliteration for gastric variceal bleeding and risky gastric varices: a 10-year experience. | Balloon-occluded retrograde transvenous obliteration (B-RTO) is a new alternative treatment for gastric varices (GVx), but the long-term efficacy is not known. We investigated the long-term effects of B-RTO on rebleeding, prevention of first bleeding, mortality and occurrence of risky esophageal varices (EVx). B-RTO wa... | 18,713,295 |
Gastric hypersensitivity induced by oesophageal acid infusion in healthy volunteers. | Distal oesophageal acid exposure has been shown to increase visceral sensitivity of the proximal oesophagus via central sensitization. Here we evaluated whether acidification of the distal oesophagus also affects the sensorimotor function of the proximal stomach. A gastric barostat study combined with a 30-min acid (HC... | 18,713,312 |
Abnormal heart rate variability and subtle atrial arrhythmia in patients with familial amyloidotic polyneuropathy. | Cardiac autonomic dysfunction is a common complication of familial amyloidotic polyneuropathy (FAP), but cardiac arrhythmia and conduction disturbances are also common. We analyzed heart rate variability (HRV) in FAP patients using power spectrum analysis and Poincaré plot analysis. HRV was analyzed in 24-hour ECG reco... | 18,713,325 |
Reproducibility and gender-related differences of heart rate variability during all-day activity in young men and women. | Only few data are available on reproducibility over time in healthy young men and women and the corresponding gender-related changes of heart rate variability (HRV) measurements. We studied temporal and spectral HRV indices obtained from 24-hour Holter recordings in 32 healthy volunteers (14 men and 18 women, mean age ... | 18,713,328 |
Ionic mechanisms and vectorial model of early repolarization pattern in the surface electrocardiogram of the athlete. | The electrocardiogram (ECG) of the athlete displays particular characteristics as a consequence of both electrophysiological and autonomic remodeling of the heart that follows continued physical training. However, doubts persist on how these changes directly interact during ventricular activation and repolarization ult... | 18,713,332 |
Monoclonal antibody-based enzyme linked immunosorbent assay for the analysis of jasmonates in plants. | Methyl jasmonate (MeJA) and its free-acid form, jasmonic acid (JA) are naturally occurring plant growth regulators widely distributed in higher plants. In order to improve the sensitivity for the analysis of MeJA at low levels in small amounts of plant samples, a monoclonal antibody (MAb) (designated as MAb 3E(5)D(7)C(... | 18,713,355 |
Growth inhibition occurs independently of cell mortality in tomato (Solanum lycopersicum) exposed to high cadmium concentrations. | In order to analyze the adaptation potential of tomato shoots to a sudden increase in Cd concentration, tomato plants (Solanum lycopersicum L. var. Ailsa Craig) were exposed under controlled environmental conditions to a high dose of this heavy metal (250 microM CdCl2) in nutrient solution for 7 and 14 d. Both root and... | 18,713,362 |
Rapid inactivation of chloroplastic ascorbate peroxidase is responsible for oxidative modification to Rubisco in tomato (Lycopersicon esculentum) under cadmium stress. | To investigate the sensitive site of antioxidant systems in chloroplast under cadmium stress and its consequence on reactive oxygen species production and action, the sub-organellar localization of chloroplast superoxide dismutases (SOD, EC 1.15.1.1) and ascorbic peroxidase (APX, EC 1.11.1.11) isoenzymes and changes of... | 18,713,375 |
Genetic basis of ethylene perception and signal transduction in Arabidopsis. | Ethylene is a simple gaseous hormone in plants. It plays important roles in plant development and stress tolerance. In the presence of ethylene treatment, all ethylene receptors are in an activated form, which can physically interact with CTR1 and consequently recruit CTR1 protein to endoplasmic reticulum membraneto ac... | 18,713,391 |
Overexpression of sweet pepper glycerol-3-phosphate acyltransferase gene enhanced thermotolerance of photosynthetic apparatus in transgenic tobacco. | In order to investigate the relationship between the lipid composition in thylakoid membrane and thermostability of photosynthetic apparatus, tobacco transformed with sweet pepper sense glycerol-3-phosphate acyltransferase (GPAT) gene were used to analyze the lipid composition in thylakoid membrane, the net photosynthe... | 18,713,430 |
Reproductive allocation patterns in different density populations of spring wheat. | The effects of increased intraspecific competition on size hierarchies (size inequality) and reproductive allocation were investigated in populations of the annual plant, spring wheat (Triticum aestivum). A series of densities (100, 300, 1000, 3000 and 10,000 plants/m(2)) along a gradient of competition intensity were ... | 18,713,435 |
Correlation between CD4 counts of HIV patients and enteric protozoan in different seasons - an experience of a tertiary care hospital in Varanasi (India). | Protozoan infections are the most serious among all the superimposed infections in HIV patients and claim a number of lives every year. The line of treatment being different for diverse parasites necessitates a definitive diagnosis of the etiological agents to avoid empirical treatment. Thus, the present study has been... | 18,713,475 |
A comparison of patient perceptions and physician practice patterns related to HIV testing. | In the past 25 years, human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) have become leading causes of illness and death in the United States. Over 1 million people are living with HIV/AIDS in this country, yet there continue to be many individuals who are unaware of their HIV status. Effo... | 18,713,480 |
Wood smoke-associated lung disease: a clinical, functional, radiological and pathological description. | Approximately half of the world's population, and up to 90% of households in rural areas of developing countries, depend on biomass for cooking and heating. The National Institute of Respiratory Diseases, México City. To describe wood smoke-associated lung disease (WSLD). Description of the clinical, functional and rad... | 18,713,510 |
Development and validation of an EI-GC-MS method for the determination of methadone and its major metabolites (EDDP and EMDP) in human breast milk. | Methadone is used extensively for the maintenance of opioid-addicted pregnant women. Because methadone and the two major metabolites, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyrroline (EMDP), are excreted into breast milk, a sensitive and specific gas chromatographic-ma... | 18,713,515 |
The patient's perspective of computerised records: a questionnaire survey in primary care. | The general practice consultation today has become a three-way process where patient, doctor and computer interact. Some studies have shown that the introduction of the computer has caused concern to some patients, possibly affecting their behaviour. If patients are less frank about their problems in a computer-mediate... | 18,713,525 |
Driving and neurodegenerative diseases. | The proportion of elderly people in the general population is rising, resulting in greater numbers of drivers with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. These neurodegenerative disorders impair cognition, visual perception, and motor function, leading to reduced driver fitness... | 18,713,573 |
Cavitary anomalies of the optic disc: neurologic significance. | Cavitary congenital optic disc anomalies include optic disc coloboma, morning glory disc anomaly, optic pit, and the papillorenal syndrome. Peripapillary staphyloma is occasionally included in this group but it does not represent an anomaly of the optic disc itself and is not discussed herein. A variety of systemic and... | 18,713,577 |
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