title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms. | Despite a relatively simple core-signaling transduction machinery, Notch signaling controls cell differentiation in many different tissues and at multiple stages in a given cell lineage. To understand how Notch generates this multitude of cellular responses, it is important to learn how the Notch-signaling output is mo... | 18,722,525 |
Cloning and characterization of a cDNA clone encoding troponin T from tick Haemaphysalis qinghaiensis (Acari: Ixodidae). | Troponin T (TnT) is a key protein for Ca(2+)-sensitive molecular switching of muscle contraction. The entire cDNA sequence of Haemaphysalis qinghaiensis troponin T gene (HqTnT) from the hard tick was cloned here. The cDNA sequence of HqTnT possesses an ORF of 1170 bp coding for a mature protein with 389 amino acid resi... | 18,722,546 |
Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention. | Recent experimental and clinical studies have placed new emphasis on the role of the innate immune system in SLE. Nucleic acid-containing immune complexes activate the innate response by engaging specific Toll-like receptors (TLRs) and promote the generation of autoantibodies. Pharmacologic modulation of TLR-directed p... | 18,722,558 |
Osteochondroma developing from the xyphoid appendix into an abdominal wall scar from a previous laparotomy. | We describe herein the case of a 45-year-old man who developed an osteochondroma from the xyphoid appendix into an abdominal wall scar from a laparotomy performed 4 years previously. To our knowledge, rare cases of osteochondroma of the xyphoid bone have been documented in the literature. As shown by the tumor's rapid ... | 18,722,584 |
Fatigue resistance during a voluntary performance task is associated with lower levels of mobility in cerebral palsy. | To investigate muscle fatigue of the knee flexors and extensors in people with cerebral palsy (CP) compared with those without motor disability during performance of a voluntary fatigue protocol and to investigate the relationship with functional mobility. A case-control study. A biomechanics laboratory. Ambulatory sub... | 18,722,588 |
A stochastic model of tumor angiogenesis. | Angiogenesis is a prerequisite for the growth, invasion and metastasis of solid tumors. The aim of this study was to investigate the changes of microvessel densities in tumor with a method of probability. We showed that the stages of tumor angiogenesis may follow a probabilistic pattern compatible with Markov chain and... | 18,722,598 |
Prevalence and risk factors of irritable bowel syndrome in Korean adolescent girls: a school-based study. | Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, with a strong female predominance. When compared to the vast knowledge pertaining to adults with IBS, very little is known about IBS in the adolescent population. In Korea, the field of adolescent health with IBS is just beg... | 18,722,617 |
High dietary menaquinone intake is associated with reduced coronary calcification. | Dietary vitamin K is thought to decrease risk of cardiovascular disease by reducing coronary calcification, but inconsistent results are reported. This may be due to different effects of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone, MK), but few studies included both. We investigated the association of in... | 18,722,618 |
Adult Wilms tumor during gestational period. | We present a case of a 17-year-old pregnant girl, with hematuria. Magnetic resonance imaging showed a solid left renal mass. The patient had a radical nephrectomy during the 20th week gestation and the diagnosis was nephroblastoma. She gave birth to a healthy child at term and refused adjuvant treatment. She is disease... | 18,722,653 |
Subacute toxicity of polychlorinated naphthalenes and their effect on cytochrome P-450. | The aim of the study was to investigate the subacute toxicity of a polychlorinated naphthalene (PCN) mixture and its effect on cytochrome P-450 levels in rats. The animals were administered PCNs intragastrically in repeated daily doses of 1, 10, and 100 mg/kg. The animals were dissected after 7, 14, or 21 doses. Doses ... | 18,722,660 |
Chitosan microspheres as candidate plasmid vaccine carrier for oral immunisation of Japanese flounder (Paralichthys olivaceus). | Oral DNA-based immunotherapy is a new treatment option for fish immunisation in intensive culture. However, because of the existence of the nucleases and severe gastrointestinal conditions, DNA-based vaccines can be hydrolyzed or denatured. In our laboratory, a plasmid DNA (pDNA) containing major capsid protein (MCP) g... | 18,722,672 |
Dose-individualized stereotactic body radiotherapy for T1-3N0 non-small cell lung cancer: long-term results and efficacy of adjuvant chemotherapy. | To evaluate the efficacy of dose-individualized stereotactic body radiotherapy (SBRT) and adjuvant chemotherapy in stage T1-3N0M0 non-small cell lung cancer (NSCLC). Sixty-five patients with T1-3N0M0 NSCLC treated by SBRT between April 2001 and August 2005 were included. Twenty patients were CT-staged at stage T1, 34 a... | 18,722,684 |
Effect of cationic and anionic surfactants on the sorption and desorption of perfluorooctane sulfonate (PFOS) on natural sediments. | Sorption and desorption of PFOS at water-sediment interfaces were investigated in the presence of a cationic surfactant, cetyltrimethylammonium bromide (CTAB), and an anionic surfactant, sodium dodecylbenzene sulfonate (SDBS). CTAB remarkably enhanced the sorption of PFOS on the sediment. In contrast, the influence of ... | 18,722,698 |
Sensor-based neuronavigation: evaluation of a large continuous patient population. | Navigation systems enable neurosurgeons to guide operations with imaging data. Sensor-based neuronavigation uses an electromagnetic field and sensors to measure the positions of the patient's brain anatomy and the surgical instruments. The aim of this investigation was to determine the accuracy level of sensor-based tr... | 18,722,707 |
Olive mill wastewater degradation by Fenton oxidation with zero-valent iron and hydrogen peroxide. | The degradation of olive mill wastewater (OMW) with hydroxyl radicals generated from zero-valent iron and hydrogen peroxide has been investigated by means of chemical oxygen demand (COD) and phenolic compounds analyses. The effects of the H2O2 dose, the pH and the organic matter concentration have been studied. The opt... | 18,722,712 |
[Current data on vaccines for respiratory diseases]. | Respiratory tract infections are a major reason of antibiotic prescription. Some of these infections can be prevented by vaccination. In France, the main new data concerns the following vaccines: Haemophilus influenzae: besides the vaccine effectiveness H. influenzae b, that is a virulent capsulated strain, a polyvalen... | 18,722,726 |
Clinical analysis of hyponatremia in acute craniocerebral injury. | To explore pathological mechanisms of central hyponatremia and its treatment. Synchronous assay was made for changes of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), endogenous digitalis-like substance (EDLS), antidiuretic hormone (ADH) in blood, and Na(+) concentrations in blood and urine, and pla... | 18,722,740 |
Selective axillary node sampling and radiotherapy to the axilla in the management of breast cancer. | Axillary treatment for patients with early-stage breast cancer can be associated with considerable morbidity. Techniques, such as axillary node sampling (ANS) and, more recently, sentinel node biopsy, in combination with radiotherapy have the potential to reduce toxicity. A retrospective review of axillary treatment in... | 18,722,758 |
On-chip detection of protein glycosylation based on energy transfer between nanoparticles. | We describe a chip-based method to detect protein glycosylation based on the energy transfer between quantum dots (QDs) and gold nanoparticles (AuNPs). Our assay system relies on modulations in the energy transfer between the nanoparticles on a surface. The photoluminescence (PL) of lectin-coated QDs (energy donor) imm... | 18,722,763 |
The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status. | The aim of this study is to evaluate if mismatch repair (MMR) defective colorectal cancer has a different response to adjuvant 5-fluorouracil (5-FU) chemotherapy in a cohort of patients prospectively followed during 5 years. The cohort included 754 surgically treated patients with colorectal cancer. MMR status was diag... | 18,722,765 |
ortho-dihydroxyisoflavone derivatives from aged Doenjang (Korean fermented soypaste) and its radical scavenging activity. | One new ortho-dihydroxyisoflavone, 7,3',4'-trihydroxyisoflavone (2), and two known ortho-dihydroxyisoflavone derivatives were isolated from 5-year-old Doenjang (Korean fermented soypaste), and evaluated as potent antioxidant by comparing with other known isoflavones. 7,8,4'-Trihydroxyisoflavone (1), 7,3',4'-trihydroxyi... | 18,722,771 |
Optimizing patellofemoral arthroplasty. | Patellofemoral arthroplasty (PFA) has been an option for patients with symptomatic patellofemoral osteoarthritis since the 1950's. Many of the early failures resulted from a combination of implant design and surgeon technique. The goal of this overview is not to review the history of PFA, but rather to explore options ... | 18,722,775 |
Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines. | Obesity with insulin resistance and alcohol are the most frequent causes of steatohepatitis. This work investigates the contribution of bioactive TNF and Th1 type cytokines in a mouse model of steatohepatitis induced by FAT alone or FAT+EtOH and endotoxin. The extent of liver injury and cytokine activation induced by e... | 18,722,787 |
Care in people 60 years of age and over with chronic or recently diagnosed epilepsy: a note review in United Kingdom general practice. | To ascertain present United Kingdom (UK) management processes for epilepsy in older people. This was a general practice notes review of people being treated for epilepsy 60 years and over. The cohort of 110 was from six practices. Seizure frequency in older people with epilepsy appears lower than in general; 75% are se... | 18,722,793 |
Endovascular therapy of a symptomatic mobile thrombus of the thoracic aorta. | The therapeutic strategies of a mobile luminal thrombus of the descending thoracic aorta with peripheral arterial embolization remain a matter of debate. We report the case of recurrent peripheral arterial embolism caused by a mobile thrombus of the descending aorta, which was successfully treated by implanting an endo... | 18,722,794 |
DFT based computational study on the excited state intramolecular proton transfer processes in o-hydroxybenzaldehyde. | Potential energy (PE) curves for the intramolecular proton transfer in the ground (GSIPT) and excited (ESIPT) states of o-hydroxybenzaldehyde (OHBA) were studied using DFT-B3LYP/6-31G(d) and TD-DFT-B3LYP/6-31G(d) level of theory, respectively. Our calculations suggest the non-viability of ground state intramolecular pr... | 18,722,808 |
Parasympathetic response to acute stress is attenuated in young Zucker obese rats. | We compared arterial blood pressure (BP) and heart rate (HR) control in 9- to 11-week old obese Zucker rats (n=10; weight=452+/-45 g, average+/-SD) to age-matched, lean Zucker animals (n=13; weight=280+/-46 g). BP was measured by indwelling catheter. Baseline pressure was 113.1+/-7.0 mm Hg in the lean vs. 111.7+/-5.6 i... | 18,722,824 |
Pulmonary function in the morbidly obese. | Only limited data exist on the relationship of lung function to patients with extreme obesity. To assess the relationship between lung function tests and clinical characteristics in a cohort of morbidly obese patients undergoing evaluation for bariatric procedures in a university hospital in the United States. Consecut... | 18,722,823 |
Closure of a contained open abdomen using a bipedicled myofascial oblique rectus abdominis flap technique. | A contained open abdomen is commonly used during damage control laparotomy and consists of the temporary coverage of the abdomen for protection of the viscera and reduction of intra-abdominal pressure. Definitive closure of a contained open abdomen is technically difficult due to the inability to obtain primary fascial... | 18,722,829 |
Evaluating the evidence: guidelines. | Guidelines are collections of practical information that assist with clinical decision making. Evidence-based guideline development includes a critique of the quality and an evaluation of the strength of published evidence. Evolution From opinion-based to evidence-based guidelines is incomplete in many of the organizat... | 18,722,835 |
Controlled-substance returns in the operating suite. | Drug diversion is an ongoing problem in health care settings. The potential for drug diversion incidents in the perioperative area is high because of the availability of narcotics and other controlled substances and the stresses of working in this environment. The flow of controlled substances traditionally has been mo... | 18,722,838 |
Role of spiral computed tomography with 3-dimensional reconstruction in cases with laryngeal stenosis--a radioclinical correlation. | To study the efficacy of spiral computed tomography with 3-dimensional reconstruction (SCT-3DI) and endoscopy in cases with laryngeal stenosis with regard to site, type, grade, and length of stenosis and to determine the correlation among the findings of SCT-3DI, endoscopy, and surgery. This prospective study on 30 cas... | 18,722,886 |
Internal pedal amputations. | Internal pedal amputation consists of resection of the metatarsals, midtarsal bones, or talus with preservation of the toes and soft-tissue envelope. Although used in the past for the treatment of tuberculosis within the pedal skeleton, internal pedal amputations have become almost forgotten, historical procedures. How... | 18,722,904 |
Minimally invasive soft-tissue and osseous stabilization (MISOS) technique for midfoot and hindfoot deformities. | The surgical repair of unstable midfoot and hindfoot deformities in the high-risk patient remains a challenge with little guidance available in the literature. The author presents a proposed surgical intervention for midfoot and hindfoot deformities utilizing a minimally invasive soft-tissue and osseous stabilization (... | 18,722,905 |
Percutaneous bone marrow aspirate and bone graft harvesting techniques in the lower extremity. | Autogenous bone marrow aspirate and cancellous bone graft represent a useful adjuvant to enhance soft tissue and osseous healing in high-risk patients. The authors present a review of the pertinent literature and step-by-step guidelines for performing reliable, simple, and reproducible percutaneous surgical techniques ... | 18,722,909 |
Regional chemotherapy: overview. | Regional chemotherapy was developed in the 1950s and continues to play an integral part in the development of newer therapies for advanced solid malignancies. Regional therapies have evolved in complexity but are still based on the pharmacokinetics of drug delivery to solid malignancies. Newer techniques demonstrate th... | 18,722,914 |
Regional chemotherapy for carcinoma of the lung. | The potential benefit of regional chemotherapy is to reach high local drug concentrations in the treated area by reducing systemic side effects. Today, different application forms are available, such as intra-arterial infusion, sometimes in form of chemoembolization; intracavitary application techniques, such as intrap... | 18,722,925 |
Longterm results of a prospective study of 225 femoral hernia repairs: indications for tissue and mesh repair. | Femoral hernias are uncommon, and there are relatively few clinical studies of longterm outcomes after repair. Although the McVay repair has been classically described, the infrainguinal plug technique has gained popularity in recent years. Evidence supporting these repairs is sparse. A prospective study of elective fe... | 18,722,941 |
Treatment of uterine myomas with transvaginal uterine artery occlusion: possibilities and limitations. | The objective of this pilot study was to evaluate the feasibility of a transvaginal clamp prototype used for temporary uterine artery occlusion as a treatment for myomas. In particular, we aimed to evaluate technical aspects of successful occlusion with angiography and magnetic resonance imaging (MRI) and to evaluate p... | 18,722,975 |
Clinico-pathological effects of Schistosoma mansoni infection associated with simultaneous exposure to malathion in Swiss outbred albino mice. | To investigate whether infection of Swiss outbred mice with the digenetic fluke Schistosoma mansoni is influenced by exposure to environmental pollutants, experimentally infected mice were exposed to 200 and 400 mg/kg of malathion. Pathology of liver and spleen, worm burden and levels of key hematological, biochemical ... | 18,722,991 |
Elimination of keratin artifact bands from western blots by using low concentrations of reducing agents. | We encountered beta-mercaptoethanol-dependent artifact signals in western blot analyses using polyclonal antisera. Replacing beta-mercaptoethanol with dithiothreitol in the loading buffer did not eliminate the artifact signals. However, lowering the concentration of either dithiothreitol or beta-mercaptoethanol elimina... | 18,722,995 |
Technique for cryopreservation of intestinal smooth muscle cells. | Attempts were made to develop a simplified procedure for long-term cryopreservation of intestinal smooth muscle cells (ISMC). ISMC were collected from the ileum of Sprague-Dawley neonatal rats through cellular dissociation in trypsin. Cryopreservation method comprised of a rapid 1-step (protocol 1) and a slow 3-step (p... | 18,723,010 |
A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. | We have previously shown the transcription factor SOX9 to be required for the maintenance of multipotential pancreatic progenitor cells in the early embryonic pancreas. However, the association of pancreatic endocrine defects with the Sox9-haploinsufficiency syndrome campomelic dysplasia (CD) implies additional later r... | 18,723,011 |
Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1-14. | Human papillomavirus type 18 (HPV18) is a common cause of cervical cancer. To create a mouse model for this common neoplastic disease, we used a human keratin 14 promoter to drive the HPV18 E7 oncogene to create transgenic mice. No mice up to a year of age developed cervical cancer. However, all transgenic mice and non... | 18,723,014 |
The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43. | Benzene is used at large volumes in many different human activities. Hematotoxicity and cancer-causation as a result of benzene exposure was recognized many years ago, but the mechanisms involved remain unclear. Aberrant regulation of gap junction intercellular communication (GJIC) has been linked to both cancer induct... | 18,723,040 |
Bothrops jararaca venom (BjV) induces differential leukocyte accumulation in mice genetically selected for acute inflammatory reaction: the role of host genetic background on expression of adhesion molecules and release of endogenous mediators. | The dynamics of the local inflammatory events induced by Bothrops jararaca venom (BjV) inoculation in footpad of mice genetically selected for maximal (AIRmax) and minimal (AIRmin) acute inflammatory reactivity (AIR) was investigated. The BjV injection induced a marked inflammatory cell infiltrate with predominance of ... | 18,723,041 |
Steroid-converting enzymes in human ovarian carcinomas. | Anti-estrogen therapies for treating ovarian carcinoma have had mixed outcomes suggesting some tumors may be estrogen-dependent. We assayed the activity levels of 17beta-hydroxysteroid dehydrogenase (17beta-HSD), 3beta-hydroxysteroid dehydrogenase (3beta-HSD), 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD/3-KSR) and ... | 18,723,074 |
Positive circuits and d-dimensional spatial differentiation: application to the formation of sense organs in Drosophila. | We discuss a rule proposed by the biologist Thomas according to which the possibility for a genetic network (represented by a signed directed graph called a regulatory graph) to have several stable states implies the existence of a positive circuit. This result is already known for different models, differential or dis... | 18,723,072 |
Haeme oxygenase and nitric oxide synthetase blockade and brain blood flow in sheep exposed to carbon monoxide. | Carbon monoxide (CO) usually does not damage the brain cortex in our in vivo model. To investigate the possible protective role of responsive and regulated changes in blood flow, 24 ewes were randomly assigned in equal numbers to sham-control, CO-control and treatment (haeme oxygenase (HO) and nitric oxide synthetase (... | 18,723,078 |
Characterization of water of hydration fractions in rabbit skeletal muscle with age and time of post-mortem by centrifugal dehydration force and rehydration methods. | Centrifugal dehydration force (CDF) and rehydration isotherm (RHI) methods were used to measure and characterize hydration fractions in rabbit psoas skeletal muscle. The CDF method assessed fluid flow rate from rabbit muscle and hydration capacity of the fractions. Bulk and multiple non-bulk water fractions were identi... | 18,723,101 |
Teneurins: important regulators of neural circuitry. | Teneurin (Ten-m/Odz) molecules represent a highly conserved family of four type II transmembrane proteins in vertebrates (Ten-m1-4), which exist as homodimers and undergo homophilic interactions. Each is expressed in distinct, and often interconnected, areas of the developing nervous system. Different Ten-ms have compl... | 18,723,111 |
RAP55: insights into an evolutionarily conserved protein family. | The RAP55 protein family is evolutionarily conserved in eukaryotes. Two highly conserved paralogues, RAP55A and RAP55B, exist in vertebrates; their functional properties and expression patterns remain to be compared. RAP55 proteins share multiple domains: the LSm14 domain, a serine/threonine rich region, an FDF (phenyl... | 18,723,115 |
On the prevalence of bipolar disorder in epilepsy. | Although mood disorders represent a frequent psychiatric comorbidity in epilepsy, data on bipolar disorder (BD) are still limited, and the role of possible specific confounding variables (seizures and antiepileptic drug therapy) has never been considered. Data for 143 adult outpatients with epilepsy assessed with the M... | 18,723,118 |
Aberrant T cell ERK pathway signaling and chromatin structure in lupus. | Human systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibodies to nuclear components with subsequent immune complex formation and deposition in multiple organs. A combination of genetic and environmental factors is required for disease development, but how the environment interacts wi... | 18,723,128 |
Differential expression of microRNA species in organs of hibernating ground squirrels: a role in translational suppression during torpor. | Mammalian hibernation includes long periods of profound torpor where the rates of all metabolic processes are strongly suppressed in a reversible manner. We hypothesized that microRNAs (miRNAs), small non-coding transcripts that bind to mRNA, could play a role in the global suppression of mRNA translation when animals ... | 18,723,136 |
Effect of blinking on tear volume after instillation of midviscosity artificial tears. | To determine by optical coherence tomography (OCT) the effect of blinking on ocular surface tear volume after instillation of artificial tears. Experimental study. Normal human eyes (n = 21) were imaged to obtain dimensions of the tear film and menisci during blinking. The imaging was carried out immediately and five m... | 18,723,145 |
Factors associated with delayed postsurgical voiding interval in ambulatory spinal anesthesia patients: a prospective cohort study in 3 types of surgery. | Spinal anesthesia has been considered inappropriate for ambulatory surgery patients because of concern about voiding dysfunction. The purpose of this study was to analyze the relationship between voiding interval and type of surgery under spinal anesthesia with lidocaine and to identify other nonanesthetic risk factors... | 18,723,151 |
Scientific Impact Recognition Award: Molecular breast imaging: a review of the Mayo Clinic experience. | Molecular breast imaging (MBI) depicts functional uptake of targeted radiotracers in the breast using dedicated gamma cameras. MBI studies were performed under several institutional protocols evaluating the use of MBI in screening and diagnosis. By using a single-head system, sensitivity for breast cancer detection was... | 18,723,155 |
Combining early markers strongly predicts conversion from mild cognitive impairment to Alzheimer's disease. | The utility of combining early markers to predict conversion from mild cognitive impairment (MCI) to Alzheimer's Disease (AD) remains uncertain. Included in the study were 148 outpatients with MCI, broadly defined, followed at 6-month intervals. Hypothesized baseline predictors for follow-up conversion to AD (entire sa... | 18,723,162 |
Preparative isolation and purification of two benzoxazinoid glucosides from Acanthus ilicifolius L. by high-speed counter-current chromatography. | The first preparative separation of two benzoxazinoids, (2R)-2-O-beta-d-glucopyranosyl-2H-1,4-benzoxazin-3(4H)-one (HBOA-Glc) and (2R)-2-O-beta-d-glucopyranosyl-4-hydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA-Glc), by means of high-speed counter-current chromatography (HSCCC) from the n-butanol extract of Acanthus ilicifo... | 18,723,179 |
Controlled deposition of calcium carbonate particles on porous membranes by using alternating current system. | The deposition of calcium carbonate particles in the absence of additives was performed through the application of an alternating current. Solutions of calcium chloride and sodium carbonate were filled in glass cells, and a porous polymer membrane was interposed between the glass cells. An alternating current with a si... | 18,723,181 |
Analysis of compositional data in communication disorders research. | The study of communication and its disorders often involves coding several behaviors and examining the proportions with which individual behaviors are produced within data sets. Problems are encountered when studying multiple behaviors between data sets, because of the interdependence of the proportions: as one coded b... | 18,723,184 |
Prognostic significance of inverse spatial QRS-T angle circadian pattern in myocardial infarction survivors. | We investigated the predictive value of the spatial QRS-T angle (QRSTA) circadian variation in myocardial infarction (MI) patients. Analyzing 24-hour recordings (SEER MC, GE Marquette) from 151 MI patients (age 63 +/- 12.7), the QRSTA was computed in derived XYZ leads. QRS-T angle values were compared between daytime a... | 18,723,188 |
Antitumoral and antileishmanial dioncoquinones and ancistroquinones from cell cultures of Triphyophyllum peltatum (Dioncophyllaceae) and Ancistrocladus abbreviatus (Ancistrocladaceae). | From the methanolic extracts of solid callus cultures from two species of the closely related palaeotropical plant families Dioncophyllaceae and Ancistrocladaceae seven new natural naphthoquinones were isolated, dioncoquinones A (4) and B (5) from Triphyophyllum peltatum, and ancistroquinones B (6), C (7), D (9), E (10... | 18,723,197 |
Polymer biodegradation: mechanisms and estimation techniques. | Within the frame of the sustainable development, new materials are being conceived in order to increase their biodegradability properties. Biodegradation is considered to take place throughout three stages: biodeterioration, biofragmentation and assimilation, without neglect the participation of abiotic factors. Howeve... | 18,723,204 |
Absorption of nitro-polycyclic aromatic hydrocarbons by biomembrane models: effect of the medium lipophilicity. | To demonstrate the relationship between the structure of nitro-polycyclic aromatic hydrocarbons and their effect on biomembranes, we have investigated the influence of three structurally different nitro-polycyclic aromatic hydrocarbons, 2-nitrofluorene, 2,7-dinitrofluorene and 3-nitrofluoranthene, on the thermotropic b... | 18,723,205 |
Muscle sympathetic nerve activity in patients with Chagas' disease. | The progression of heart failure in Chagas' disease has been explained by remodeling, leading to neurohumoral activation, or by the direct parasite damage to parasympathetic neurons during acute phase, leading to early sympathetic activation and progressive heart failure. To help distinguish between these hypotheses we... | 18,723,231 |
Adsorption characteristics of As(V) on iron-coated zeolite. | The sorption characteristics of arsenic(As(V)) on iron-coated zeolite (ICZ) were investigated through batch and column studies. As(V) was completely removed within 30 min in a concentration of 2mg/l, with a 100g/l dose of ICZ. Optimum dose of ICZ was 33.3g/l at a concentration of 20.12 mg/l and the effect of solution p... | 18,723,277 |
Patient-provider communication and cancer screening among unmarried women. | Unmarried women are less likely than married women to receive recommended cancer screenings. Patient-provider communication is a consistent predictor of cancer screening among women. The purpose of this study was to investigate the relationship between patient and provider communication, barriers to cancer screening, a... | 18,723,307 |
Application of quantitative tissue velocity imaging to evaluate left ventricular early diastolic dysfunction in dogs with heart failure due to rapid ventricular pacing. | The authors assessed the capability of quantitative tissue velocity imaging (QTVI) to detect left ventricular (LV) early diastolic dysfunction (LVEDDY) in a canine model. Rapid ventricular pacing (RVP) at 240 beats/min was maintained in 14 dogs for 2 weeks. Echocardiography, cardiac catheterization, and endomyocardial ... | 18,723,320 |
Role of surfactants in optimizing fluorene assimilation and intermediate formation by Rhodococcus rhodochrous VKM B-2469. | Biodegradation of fluorene by Rhodococcus rhodochrous VKM B-2469 was investigated and optimized by adding non-ionic surfactants to the liquid media. The utilization of 1-1.5% Tween 60 or 1% Triton X100 allowed to solubilize 1 mM fluorene over 150 times more than in water medium (from 9-11 microM to above 1.5 mM at 28 d... | 18,723,343 |
Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release. | Investigation of the roots of Myrica nana afforded five new cyclic diarylheptanoids, myricananins A-E (1-5), two new artifacts of myricananins A and B (6-7), and four known compounds, 12-hydroxymyricanone (8), alnusonol (9), myricatomentogenin (10), and actinidione (11). The structures of these new compounds were estab... | 18,723,353 |
Patency rate of the internal thoracic artery to the left anterior descending artery bypass is reduced by competitive flow from the concomitant saphenous vein graft in the left coronary artery. | In coronary artery bypass grafting (CABG), insufficient bypass flow can be a cause of occlusion or string sign of the internal thoracic artery (ITA) graft. A patent saphenous vein (SV) graft from the ascending aorta can reduce the blood flow through the ITA graft, and may affect its long-term patency. In the present st... | 18,723,364 |
Multidimensional geriatric assessment in treatment decision in elderly cancer patients: 6-year experience in an outpatient geriatric oncology service. | This prospective cohort study of consecutive elderly cancer patients was undertaken to evaluate the role of the multidimensional geriatric assessment (MGA) as an aid in treatment decision-making. A total of 571 cancer patients (aged > or =70) were enrolled during 6-year (1999-2005). All underwent MGA as part of the ... | 18,723,367 |
Palonosetron plus dexamethasone effectively prevents acute and delayed chemotherapy-induced nausea and vomiting following highly or moderately emetogenic chemotherapy in pre-treated patients who have failed to respond to a previous antiemetic treatment: comparison between elderly and non-elderly patient response. | Aim of the present phase II non-randomized study was to verify whether palonosetron might be able to prevent acute and especially delayed CINV for either HEC or MEC, starting from the second chemotherapy cycle, in patients who had failed to respond to a different antiemetic 5-HT(3) antagonist during the first cycle. St... | 18,723,369 |
Frequency and patterns of MRI abnormalities due to status epilepticus. | MRI changes due to status epilepticus (SE) often suggest a combination of cytotoxic and vasogenic edema, but it is unclear why only certain patients have MRI changes. To determine the frequency of MRI changes due to SE and the associated patient characteristics. We reviewed records for demographics, medical history, an... | 18,723,376 |
Population data for 15 autosomal STRs loci and 12 Y chromosome STRs loci in a population sample from the Sardinia island (Italy). | One hundred twenty-five unrelated individuals (69 females and 56 males) from Sassari (Northern Sardinia) and Orgosolo (Central Sardinia) were typed for 15 STRs loci. The 56 males were typed for 12 Y chromosome STRs loci too. Frequency distribution is described. | 18,723,383 |
Human herpesvirus 8 DNA quantification in matched plasma and PBMCs samples of patients with HHV8-related lymphoproliferative diseases. | The quantitative evaluation of human herpesvirus 8 (HHV8) DNA is not well described in the clinical management of HHV8-related lymphoproliferative diseases. To evaluate and to compare HHV8 viral load in different blood compartments from patients with multicentric Castleman's disease (MCD), primary effusion lymphoma (PE... | 18,723,390 |
Reliability of transcranial magnetic stimulation for mapping swallowing musculature in the human motor cortex. | Although transcranial magnetic stimulation (TMS) has been widely used to study motor cortex organization and excitability, the reliability of this technique has not been thoroughly investigated. Furthermore, previous reports of TMS reliability have been restricted to upper limb musculature. We sought to determine the t... | 18,723,391 |
Identifying the target mRNAs of microRNAs in colorectal cancer. | MicroRNAs (miRNAs) play an important role in gene regulatory networks by inhibiting the expression of target mRNAs. There is a growing interest in identifying the relationship between miRNAs and their target mRNAs. Various experimental studies have been carried out to discover miRNAs involved in cancer and to identify ... | 18,723,399 |
Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. | Outcomes of unrelated donor cord blood transplantation in 191 hematologic malignancy children (median age, 7.7 years; median weight, 25.9 kg) enrolled between 1999 and 2003 were studied (median follow-up, 27.4 months) in a prospective phase 2 multicenter trial. Human leukocyte antigen (HLA) matching at enrollment was 6... | 18,723,429 |
Isoniazid or moxifloxacin in rifapentine-based regimens for experimental tuberculosis? | Recent studies have demonstrated that combined substitutions of rifapentine for rifampin and moxifloxacin for isoniazid in the standard, daily, short-course regimen of rifampin, isoniazid, and pyrazinamide produces stable cure in 12 weeks or less. This study was designed to more precisely evaluate the contribution of m... | 18,723,432 |
Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways. | The neuropilin (Nrp)1 receptor is essential for both nervous and vascular system development. Nrp1 is unusually versatile, because it transmits both chemoattractive and repulsive signals in response to vascular endothelial growth factor (VEGF)-A and class 3 semaphorins, respectively. Both Nrp1 and VEGF receptor 2 under... | 18,723,443 |
High-content imaging characterization of cell cycle therapeutics through in vitro and in vivo subpopulation analysis. | Although the cycling of eukaryotic cells has long been a primary focus for cancer therapeutics, recent advances in imaging and data analysis allow even further definition of cellular events as they occur in individual cells and cellular subpopulations in response to treatment. High-content imaging (HCI) has been an eff... | 18,723,491 |
Tumor-associated CD75s- and iso-CD75s-gangliosides are potential targets for adjuvant therapy in pancreatic cancer. | Pancreatic adenocarcinoma confers one of the highest mortality rates in malignant human tumors with very poor prognosis. Because as yet no treatments are available that produce a substantial survival benefit for this fatal neoplasia, new therapeutic concepts are urgently required to support cancer standard treatment. I... | 18,723,492 |
Chondrocyte aggregation in suspension culture is GFOGER-GPP- and beta1 integrin-dependent. | Isolated chondrocytes form aggregates in suspension culture that maintain chondrocyte phenotype in a physiological pericellular environment. The molecular mechanisms involved in chondrocyte aggregation have not been previously identified. Using this novel suspension culture system, we performed mRNA and protein express... | 18,723,503 |
Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta. | Sildenafil, a potent inhibitor of phosphodiesterase-5 (PDE-5) induces powerful protection against myocardial ischemia-reperfusion injury. PDE-5 inhibition increases cGMP levels that activate cGMP-dependent protein kinase (PKG). However, the cause and effect relationship of PKG in sildenafil-induced cardioprotection and... | 18,723,505 |
Three-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain. | The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is a membrane-integral protein that belongs to an ATP-binding cassette superfamily. Mutations in the CFTR gene cause cystic fibrosis in which salt, water, and protein transports are defective in various tissues. Here we expressed wild-type ... | 18,723,516 |
The effects of short-term antioxidant supplementation on oxidative stress and flight performance in adult budgerigars Melopsittacus undulatus. | Antioxidants are known to play an important role in quenching reactive oxygen species (ROS), thus ameliorating oxidative stress. Since increased metabolism associated with exercise can increase oxidative stress, dietary antioxidants may be a limiting factor in determining aspects of physical performance. Here we tested... | 18,723,545 |
Sustained changes in lipid profile and macrophage migration inhibitory factor levels after anti-tumour necrosis factor therapy in rheumatoid arthritis. | Macrophage migration inhibitory factor (MIF) has recently emerged as an important cytokine possibly linking rheumatoid arthritis (RA) and atherogenesis. Because atherogenesis is accelerated in RA this study was conducted to investigate whether anti-tumour necrosis factor (TNF) therapy could lead to sustained downregula... | 18,723,565 |
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage. | Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood. We establish by genetic means that CL targets DNA gyrase in the gram-positive bacterium Streptococcus pneumoniae, and promotes... | 18,723,572 |
Negative vascular remodelling after implantation of bioabsorbable magnesium alloy stents in porcine coronary arteries: a randomised comparison with bare-metal and sirolimus-eluting stents. | We sought to assess vascular remodelling and neointima formation after implantation of bioabsorbable magnesium alloy stents (AMS). Randomised experimental study. AMS (n = 11), sirolimus-eluting stents (Cypher; n = 11) and bare-metal stents (BMS; n = 9) were randomly implanted in 31 porcine coronary arteries (n = 11 pig... | 18,723,586 |
The social behaviours of bacterial pathogens. | The term quorum sensing (QS) is used to describe communication between bacterial cells, whereby a coordinated population response is controlled by diffusible signal molecules produced by individuals. Studies on QS-mediated signalling processes in bacteria have revealed the existence of intricate regulatory networks to ... | 18,723,587 |
Updates on improvement of human athletic performance: focus on world records in athletics. | Progression of world records (WRs) in athletics is a reliable mean to assess the potentiality of the human body, which also reflects how society has evolved over time and will continue to evolve. We conducted a quantitative analysis of WRs in measurable Olympic events from nine representative disciplines (100, 400, 150... | 18,723,588 |
The origins of 168, W23, and other Bacillus subtilis legacy strains. | Bacillus subtilis is both a model organism for basic research and an industrial workhorse, yet there are major gaps in our understanding of the genomic heritage and provenance of many widely used strains. We analyzed 17 legacy strains dating to the early years of B. subtilis genetics. For three--NCIB 3610T, PY79, and S... | 18,723,616 |
Purification and characterization of the bacterial UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase WecA. | To date, the structural and functional characterization of proteins belonging to the polyprenyl-phosphate N-acetylhexosamine-1-phosphate transferase superfamily has been relentlessly held back by problems encountered with their overexpression and purification. In the present work and for the first time, the integral me... | 18,723,618 |
Characterization of spores of Bacillus subtilis that lack most coat layers. | Spores of Bacillus subtilis have a thick outer layer of relatively insoluble protein called the coat, which protects spores against a number of treatments and may also play roles in spore germination. However, elucidation of precise roles of the coat in spore properties has been hampered by the inability to prepare spo... | 18,723,620 |
Stygiolobus rod-shaped virus and the interplay of crenarchaeal rudiviruses with the CRISPR antiviral system. | A newly characterized archaeal rudivirus Stygiolobus rod-shaped virus (SRV), which infects a hyperthermophilic Stygiolobus species, was isolated from a hot spring in the Azores, Portugal. Its virions are rod-shaped, 702 (+/- 50) by 22 (+/- 3) nm in size, and nonenveloped and carry three tail fibers at each terminus. Th... | 18,723,627 |
Identification of chemosensory sensilla mediating antennular flicking behavior in Panulirus argus, the Caribbean spiny lobster. | Crustaceans sample odorants by a rapid series of flicks of the two flagella composing the distal segments of each of the paired antennules. The lateral flagella contain aesthetasc sensilla that house unimodal chemosensory neurons. Nine types of nonaesthetasc setae with putative chemosensory and mechanosensory functions... | 18,723,634 |
Rhythms of locomotion expressed by Limulus polyphemus, the American horseshoe crab: I. Synchronization by artificial tides. | Limulus polyphemus, the American horseshoe crab, has an endogenous clock that drives circatidal rhythms of locomotor activity. In this study, we examined the ability of artificial tides to entrain the locomotor rhythms of Limulus in the laboratory. In experiments one and two, the activity of 16 individuals of L. polyph... | 18,723,635 |
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