title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Identification and characterization of lactococcal-prophage-carried superinfection exclusion genes. | Superinfection exclusion (Sie) proteins are prophage-encoded phage resistance systems. In this study, genes encoding Sie systems were identified on the genomes of Lactococcus lactis subsp. cremoris MG1363 and L. lactis subsp. lactis IL1403. These Sie systems are genetically distinct and yet were shown to act specifical... | 18,723,645 |
Characterization of DegQVh, a serine protease and a protective immunogen from a pathogenic Vibrio harveyi strain. | Vibrio harveyi is an important marine pathogen that can infect a number of aquaculture species. V. harveyi degQ (degQ(Vh)), the gene encoding a DegQ homologue, was cloned from T4, a pathogenic V. harveyi strain isolated from diseased fish. DegQ(Vh) was closely related to the HtrA family members identified in other Vibr... | 18,723,647 |
Isolation and identification of bifidobacteriaceae from human saliva. | Bifidobacteriaceae were isolated from saliva and infected dentine by using a mupirocin-based selective medium. Of the saliva samples, 94% harbored bifids. The mean concentration (+/- the standard error) was 4.46 (+/-0.12) log(10)(CFU per ml + 1), and the predominant isolates were Bifidobacterium dentium, B. longum, Sca... | 18,723,652 |
The genome of Polaromonas sp. strain JS666: insights into the evolution of a hydrocarbon- and xenobiotic-degrading bacterium, and features of relevance to biotechnology. | Polaromonas sp. strain JS666 can grow on cis-1,2-dichloroethene (cDCE) as a sole carbon and energy source and may be useful for bioremediation of chlorinated solvent-contaminated sites. Analysis of the genome sequence of JS666 (5.9 Mb) shows a bacterium well adapted to pollution that carries many genes likely to be inv... | 18,723,656 |
Genetic structure and aggressiveness of Erysiphe necator populations during grapevine powdery mildew epidemics. | Isolates of the causal ascomycete of grapevine powdery mildew, Erysiphe necator, correspond to two genetically differentiated groups (A and B) that coexist on the same host. This coexistence was analyzed by investigating temporal changes in the genetic and phenotypic structures of E. necator populations during three ep... | 18,723,657 |
Salmonella and Escherichia coli O157:H7 contamination on hides and carcasses of cull cattle presented for slaughter in the United States: an evaluation of prevalence and bacterial loads by immunomagnetic separation and direct plating methods. | The hide and carcass hygiene of cull cattle at slaughter in four geographically distant regions of the United States was examined from July 2005 to April 2006 by measuring the aerobic plate counts (APC) and the prevalences and loads of Salmonella and Escherichia coli O157:H7. The geometric mean log(10) APC CFU/100 cm(2... | 18,723,661 |
Observational pain assessment versus self-report in paediatric triage. | To examine if observational pain assessment can be used for purposes of triage in children aged >3 years. A prospective, single blind, controlled trial was undertaken in children who presented to the emergency department (ED) with pain. Pain was assessed in the waiting room and again at triage before any treatment w... | 18,723,699 |
Meningitis in a butcher. | Streptococcus suis is a common pathogen in swine and infection in humans is rarely reported. When it does occur, it is considered an occupational risk associated with the handling of carcasses. Meningitis is one of the most life-threatening manifestations of S suis infection. This case of meningitis in a butcher is rep... | 18,723,720 |
Microsatellite analysis of the GLC1B locus on chromosome 2 points to NCK2 as a new candidate gene for normal tension glaucoma. | The aim of this study was to investigate the association between normal tension glaucoma and the candidate disease locus glaucoma 1, open angle, B (GLC1B) on chromosome 2. There are many reports describing the results of association or linkage studies for primary open angle glaucoma (POAG), with GLC1B as one of the loc... | 18,723,748 |
Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes. | CD38 contains an ADP ribosylcyclase domain that mediates intracellular Ca(2+) signaling by the production of cyclic ADP-ribose (cADPR), but the mechanisms by which the agonists activate this enzyme remain unclear. The present study tested a hypothesis that a special lipid-raft (LR) form, ceramide-enriched lipid platfor... | 18,723,763 |
Neonatal intrahepatocellular lipid. | There is increasing evidence that preterm birth is a risk factor for the development of adiposity associated disease, although the pathophysiological basis is unclear. We have previously shown that preterm infants have increased internal abdominal (visceral) adiposity by term. In adults increased internal adiposity is ... | 18,723,779 |
Determining the role of Tie-dyed1 in starch metabolism: epistasis analysis with a maize ADP-glucose pyrophosphorylase mutant lacking leaf starch. | In regions of their leaves, tdy1-R mutants hyperaccumulate starch. We propose 2 alternative hypotheses to account for the data, that Tdy1 functions in starch catabolism or that Tdy1 promotes sucrose export from leaves. To determine whether Tdy1 might function in starch breakdown, we exposed plants to extended darkness.... | 18,723,774 |
Veterinarians and public practice at the Virginia-Maryland Regional College of Veterinary Medicine: building on a tradition of expertise and partnership. | The Virginia-Maryland Regional College of Veterinary Medicine (VMRCVM), a regional veterinary college for Maryland and Virginia, has a long and unique tradition of encouraging careers in public and corporate veterinary medicine. The VMRCVM is home to the Center for Public and Corporate Veterinary Medicine (CPCVM), and ... | 18,723,808 |
Teaching nutrition to student veterinary technicians. | Graduates of veterinary technology programs must have the knowledge and skills to understand, implement, and encourage owner compliance with appropriate feeding recommendations for healthy animals and therapeutic regimens to promote optimal health, enhance recovery, and manage chronic disease conditions. This article d... | 18,723,817 |
Resident and graduate training in veterinary nutrition. | Training programs for veterinarians seeking board certification by the American College of Veterinary Nutrition (ACVN) are structured in one of two ways: (1) as programs similar to specialty training in other clinical disciplines or (2) as graduate programs leading to advanced degrees combined with clinical training. R... | 18,723,818 |
Estimates of cancer potency of 2,3,4,7,8-pentachlorodibenzofuran using both nonlinear and linear approaches. | Cancer potency estimates were derived for 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF) using data collected from the recently published National Toxicology Program bioassay in female Sprague-Dawley rats. By using a toxicokinetic model for 4-PeCDF, the dose-response relationship for combined liver tumors (hepatocellular ... | 18,723,826 |
Impaired arterial baroreflex function before nitrate-induced vasovagal syncope during head-up tilt test. | The aim of this study was to evaluate arterial baroreflex control of heart rate immediately before head-up tilt test (HUT)-induced vasovagal syncope (VVS). We enrolled 97 otherwise healthy subjects with recurrent unexplained syncope. After 10 min of rest in supine position, they underwent a passive HUT potentiated with... | 18,723,851 |
From enzyme to zymogen: engineering Vip2, an ADP-ribosyltransferase from Bacillus cereus, for conditional toxicity. | The adenosine diphosphate (ADP)-ribosyltransferase, Vip2 (vegetative insecticidal protein), from Bacillus cereus in combination with another protein from the same organism, Vip1, has insecticidal activity against western corn rootworm larvae. The Vip2 protein exerts its intracellular poisoning effect by modifying actin... | 18,723,852 |
Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein. | The nuclear lamina represents a protein network required for nuclear structure and function. One family of lamina proteins is defined by an approximately 40-aa LAP2, Emerin, and MAN1 (LEM) domain (LEM-D) that binds the nonspecific DNA-binding protein, barrier-to-autointegration factor (BAF). Through interactions with B... | 18,723,885 |
A practical exposure-equivalent metric for instrumentation noise in x-ray imaging systems. | The performance of high-sensitivity x-ray imagers may be limited by additive instrumentation noise rather than by quantum noise when operated at the low exposure rates used in fluoroscopic procedures. The equipment-invasive instrumentation noise measures (in terms of electrons) are generally difficult to make and are p... | 18,723,932 |
Reflections on humanizing biomedicine. | Although biomedicine is responsible for the "miracles" of modern medicine, paradoxically it has also led to a quality-of-care crisis in which many patients feel disenfranchised from the health-care industry. To address this crisis, several medical commentators make an appeal for humanizing biomedicine, which has led to... | 18,723,943 |
Medicine and the call for a moral epistemology, part II: constructing a synthesis of values. | The demands and needs of an individual patient require diverse value judgments to interpret and apply clinical data. Indeed, objective assessment takes on particular meaning in the context of the social and existential status of the patient, and thereby a complex calculus of values determines therapeutic goals. I have ... | 18,723,947 |
Mesangioproliferative glomerulonephritis: an important glomerulonephritis in nephrotic syndrome of young adult. | Mesangioproliferative glomerulonephritis (MesPGN) consists 10% of the total renal biopsy of glomerulonephritis. Aim of the present study was to find out clinicopathological changes in MesPGN and differences between diffuse and focal variety. MesPGN was seen mostly in young adults with mean age of 28.63 years for males ... | 18,723,953 |
Hepatic tuberculosis mimicking Klatskin tumor: a diagnostic dilemma. | Tubercular involvement of liver is rare and usually occurs in association with pulmonary or miliary tuberculosis, as diffuse involvement without recognizable pulmonary tuberculosis or rarely in a localized form, which presents as a tuberculoma or tubercular abscess. We report the case of a 22-year-old boy presenting wi... | 18,723,964 |
Primary marginal zone B-cell lymphoma of appendix. | Primary lymphomas of appendix are extremely rare tumors. The first case of primary lymphoma of appendix was reported by Warren in the year 1898. Incidence of primary lymphoma of appendix is 0.015% of all gastrointestinal lymphomas. This is a report of primary marginal zone B-cell lymphoma of appendix which presented as... | 18,723,967 |
Parvovirus-induced dyserythropoeisis in a child. | Most persons with parvovirus B19 infection are asymptomatic or exhibit mild, nonspecific, cold-like symptoms. However, hematologic problems associated with the infection include transient aplastic crisis, chronic red cell aplasia, mild neutropenia and thrombocytopenia. A rare hematologic manifestation is in the form of... | 18,723,978 |
Prone position is essential for detection of pulmonary vein pseudostenosis by enhanced multidetector computed tomography in patients who undergo pulmonary vein isolation. | Pulmonary vein (PV) stenosis is a major complication of PV isolation (PVI) by catheter ablation, so in the present study the optimal position for detecting PV stenosis on enhanced multidetector computed tomography (MDCT) image acquisition was determined. The 64-slice enhanced MDCT was carried out before and after PVI i... | 18,724,022 |
Congenital atresia of unilateral pulmonary veins associated with a single ventricle: a rare case report and literature review. | Congenital atresia or extreme hypoplasia of individual pulmonary veins is a rare condition that is usually asymptomatic if it only involves 1 or 2 segments of the lungs. It may be fatal if it occurs in combination with other complex cardiac defects. The patients often present with recurrent pulmonary infections, hemopt... | 18,724,038 |
Some translations in vascular neurology. The Johann Jacob Wepfer Award 2008. | 'Translation' in medicine immediately suggests 'translational research', but there are many other varieties of 'translation'. I have selected 4 translations in the field of vascular neurology in which I have been involved in different respects: (1) the translation of results from men to women, taking the example of asp... | 18,724,046 |
Dominant non-coding repeat expansions in human disease. | The general model that dominant diseases are caused by mutations that result in a gain or change in function of the corresponding protein was challenged by the discovery that the myotonic dystrophy type 1 mutation is a CTG expansion located in the 3' untranslated portion of a kinase gene. The subsequent discovery that ... | 18,724,054 |
Pancreatic ductal adenocarcinoma: cellular origin, signaling pathways and stroma contribution. | Pancreatic cancer has a very poor prognosis, in part due to its diagnosis at late stages of the disease and to limited response to chemotherapy and radiotherapy. The vast majority of pancreatic cancers are classified as pancreatic ductal adenocarcinomas (PDACs). Despite advances in knowledge on the cellular origin of P... | 18,724,072 |
Nurturing natural resources: the ecology of interpersonal relationships in women who have thrived despite childhood maltreatment. | Childhood maltreatment and its consequences are a public health issue. There continues to be a need for improving the lives and life prospects for survivors of child abuse. The important role that positive interactions can play was evident in a large study of women who considered themselves successful despite maltreatm... | 18,724,109 |
Influencing factors of outcome after lower-limb amputation: a five-year review in a plastic surgical department. | The crude major lower limb amputation procedure rate is 8.8 per 100,000 of the population per year in Taiwan. From January 2002 to October 2006, patients that received major lower limb amputation in our department were enrolled in this study. Retrospective chart reviews concerning different factors that can affect the ... | 18,724,135 |
Kappa-opioid receptor agonist protects the microcirculation of skeletal muscle from ischemia reperfusion injury. | Previous research has demonstrated that pretreatment with kappa opioid receptor (KOR) agonist protects against ischemia reperfusion (I/R) injury in cardiomyocytes and neuron cells through activation of protein kinase C. The purpose of this study is to investigate the KOR agonist's effect on I/R-injured cremaster muscle... | 18,724,138 |
Use of systemic T-lymphocyte signal transduction inhibitors in the treatment of atopic keratoconjunctivitis. | Topical immunomodulators such as tacrolimus have revolutionized the treatment of atopic dermatitis. Because T lymphocytes are integral to the pathogenesis of atopic dermatitis, systemic treatment with T-lymphocyte signal transduction inhibitors should ameliorate both the dermatologic and ocular manifestations. We descr... | 18,724,148 |
Corneal abnormalities in the NC/Nga mouse: an atopic dermatitis model. | To study corneal abnormalities in the NC/Nga mouse, which is an animal model of atopic dermatitis. To study histopathologic changes of the eyelid, conjunctiva, and cornea, we extracted the eyeballs together with upper and lower eyelids and fixed them for examination by light and electron microscopy or snap-froze them f... | 18,724,155 |
Eban health promotion intervention: conceptual basis and procedures. | This article concerns the health promotion intervention that served as the comparison condition in Project Eban, the NIMH Multisite HIV/STD Prevention Trial for African American Couples. Considerable research has documented the high rates of chronic diseases, including heart disease, cancer, stroke, and diabetes, among... | 18,724,187 |
Guided growth for fixed knee flexion deformity. | Fixed knee flexion deformity (FKFD) is an insidious problem that may complicate the management of patients with neuromuscular compromise due to cerebral palsy, spina bifida, arthrogryposis, and other conditions. The energy costs associated with crouch gait may become prohibitive and, with the inexorable progression of ... | 18,724,198 |
Inflatable bouncer-related fractures in children. | Inflatable bouncers or moonbouncers are very popular in private and public settings and are usually perceived as very safe attractions, but are associated with frequent fractures in children. To date, there are no publications in the medical literature about these types of injuries. The purpose of this study was to sho... | 18,724,203 |
Determination of lowest possible creatinine in living-donor kidney renal transplant recipients based on donor kidney function. | The objective of this study was to use information from a donor to establish the lowest possible serum creatinine (SCr) of the recipient as a means of identifying early graft dysfunction. We analyzed retrospectively 58 pairs of living donors and recipients. The lowest possible SCr was calculated from four different for... | 18,724,226 |
Multiple hybrid granular cell tumor-perineuriomas. | Hybrid peripheral nerve sheath tumors (PNSTs) are recently recognized, rarely reported entities. Very few hybrid PNSTs with elements of perineurioma have been reported. We report a case of a 47-year-old man who presented with multiple (>20) cutaneous nodules on all 4 extremities, present since childhood. The patient... | 18,724,242 |
Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases. | We report 4 cases of acinar cell carcinoma of the pancreas, 3 presenting as metastases in the ovary, the first report of this circumstance, which may pose a broad differential diagnosis and caused significant diagnostic difficulty in all the cases. The average patient age was 57 (range: 28 to 81) years. In 3 cases, the... | 18,724,247 |
Comparison of commercially available serologic kits for the detection of celiac disease. | The sensitivity and specificity of current antihuman tissue transglutaminase (tTG) IgA assays used to detect celiac disease reportedly approach 100%. In addition, the sensitivity of new generation deamidated gliadin peptide (alpha-DGP) antibody assays has also been reported to be similar to the tTG IgA assays. In routi... | 18,724,250 |
The impact of surgery in the management of the head and neck carcinoma involving the carotid artery. | To demonstrate the feasibility of the carotid artery dissection and/or resection and reanastomosis, and to show its positive impact on survival and disease control rates for the head and neck carcinomas involving the carotid artery. Tertiary center (Comprehensive Cancer Center). Case series review. The data of 90 patie... | 18,724,260 |
Host's response in otitis media: understanding genetic susceptibility. | Increasing evidence is emerging on genetic factors affecting host's response to infection in the middle ear. This review summarizes current knowledge on the field and on the contribution of nonspecific barriers, innate, and adaptive immunity. Better understanding of susceptibility to this very common disease will facil... | 18,724,267 |
Allogeneic stem cell transplantation for chronic myeloid leukemia-status in 2007. | Whereas until 2000 allo-SCT was the recommended treatment for all new patients with CML who were eligible on grounds of age and donor availability, approaches to initial therapy have changed very substantially since the introduction of imatinib mesylate. Today topical questions are (1) Should any newly diagnosed patien... | 18,724,281 |
Immunohematopoietic stem cell transplantation: introduction and 35 years of development in South Africa--the historical and scientific perspective. | Bone marrow was the traditional graft source when we introduced these procedures to South Africa. Technical details were established using rabbits as the experimental model with translation into a formally structured clinical programme at the University of Cape Town, based in the Groote Schuur Hospital, in 1972. Lack o... | 18,724,285 |
Allogeneic transplantation following nonmyeloablative conditioning for aggressive lymphoma. | Allogeneic hematopoietic SCT following myeloablative conditioning is associated with a high nonrelapse mortality and usually reserved for young, medically fit patients. The use of allogeneic stem cells is associated with a less risk of relapse, but is also associated with the risk of GVHD. The increased antitumor activ... | 18,724,296 |
High-dose chemotherapy and autologous stem cell transplantation for Hodgkin's lymphoma in the kingdom of Saudi Arabia: King Faisal specialist hospital and research center experience. | We report our experience with high-dose chemotherapy (HDC) and autologous SCT (ASCT) in 66 patients out of 113 (113 patients out of 153 had complete analysis) with primary refractory Hodgkin's lymphoma (PR-HL) who received salvage chemotherapy followed by BEAM as HDC. Median age at ASCT was 23 years. Before salvage che... | 18,724,297 |
The Japan Marrow Donor Program, the Japan Cord Blood Bank Network and the Asia Blood and Marrow Transplant Registry. | The annual number of hematopoietic stem cell transplants in Japan is about 3500, which are performed by more than 300 medical teams throughout the country. The Japan Marrow Donor Program (JMDP), initiated in 1991, has recruited 300,000 volunteer donors, accepted 20,000 patients and has facilitated more than 8000 unrela... | 18,724,304 |
The activity of hematopoietic stem cell transplantation in Korea. | Since the first successful allogeneic hematopoietic SCT (HSCT) was performed in Korea in 1983, there has been a noticeable progress in both the quantity and quality of HSCT over 24 years. There are 38 HSCT centers in Korea and the number of both allogeneic and autologous HSCTs has been increasing every year. As of Dece... | 18,724,315 |
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. | Inflammasomes are cytosolic multiprotein complexes that sense microbial infection and trigger cytokine production and cell death. However, the molecular components of inflammasomes and what they sense remain poorly defined. Here we demonstrate that 35 amino acids of the carboxyl terminus of flagellin triggered inflamma... | 18,724,372 |
Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells. | Cell-matrix interactions have critical roles in regeneration, development and disease. The work presented here demonstrates that encapsulated human mesenchymal stem cells (hMSCs) can be induced to differentiate down osteogenic and adipogenic pathways by controlling their three-dimensional environment using tethered sma... | 18,724,374 |
A dichotic listening study of attention control in older adults. | The influence of age on attentional control of bottom-up processing was investigated with a dichotic-listening paradigm. The typical right-ear-advantage (REA) without specific attentional instructions was used as a measure of bottom-up processing (non-forced condition). Top-down attentional control was evaluated by ins... | 18,724,404 |
Organ donation regulations limit donations from gay men. | New federal regulations intended to protect the health and safety of transplant recipients came into force on 7 December 2007. | 18,724,453 |
[Purification and reactivity of foot-and-mouth disease virus non-structural protein 3A, 3B and 2C expressed in E. coli]. | To purify and to detect reactivity of non-structural proteins 3A, 3B and 2C expressed in the Escherichia coli. FMDV NSP 3A, 3B and 2C containing the major B-cell antigenic sites were expressed in E. coli. We got renatured 2C protein by lysing of isolated inclusion body using high concentration of urea, and then diluted... | 18,724,495 |
The View-Master Health Study Focus Groups. | Trichloroethylene (TCE), a common groundwater contaminant, was found at high levels at an Oregon work site in 1998. According to a recent report released by the National Research Council, "the evidence on carcinogenic risk and other health hazards from exposure to trichloroethylene has strengthened since 2001." A conve... | 18,724,499 |
[Informed consent. Efficient communication and autonomous decision-making]. | Informed consent belongs to a new way to understand doctor-patient relationships from a perspective permitting a principle of autonomy. Seen from this viewpoint, we speak of a medical relationship understood as being a mutual relationship. For a decision to be autonomous, it must be intentional, taken after adequately ... | 18,724,513 |
[Effect of growth factor on the phenotype of subpopulations and on the kinetics of CD34+ cells in the peripheral blood and in grafts of peripheral stem cells in patients with non-Hodgkin's lymphoma indicated for autologous peripheral blood stem cell transplantation]. | Peripheral blood stem cells are the preferred source for transplantation of hematopoiesis in patients with non-Hodgkin's lymphoma. Application of hematopoietic growth factors is a part of the mobilization chemotherapy regimen. Time overlap of the highest leukocyte and CD34+ cell count is required for optimal graft coll... | 18,724,529 |
Esophageal stenting for the palliation of malignant dysphagia. | Self-expanding metal stents (SEMS) are currently the standard for palliation of malignant dysphagia. Innovations in stent technology, including the advent of retrievable stents and the development of self-expanding plastic stents (SEPS), show promise to increase the possible applications for esophageal stents. This art... | 18,724,535 |
[Physiological maternal changes during pregnancy and their consequence in GP-practice]. | Physiological maternal changes, as well as signs and symptoms during pregnancy were presented. Changes in cardiopulmonary, urinary, digestive tract, metabolic and endocrinal changes in the light of practical application in G-P practice were presented. | 18,724,547 |
[Sinusoidal obstruction disease (SOS), previous hepatic venoocclusive disease (VOD)--still serious complication after hematopoietic stem cell transplantation]. | Hepatic venocclusive disease (VOD) lastly named sinusoidal obstruction syndrome (SOS) is a serious toxicity associated with high dose therapy used to prepare patients for stem cell transplantation. A sizable proportion of patients who develop VOD/SOS die. It is clear that injury to endothelial cells and hepatocytes in ... | 18,724,548 |
Visual analogue scales and assessment of quality of life in cancer. | Assessment of quality of life (QOL) in cancer clinical trials is important when comparing treatments, especially when prolonged survival is not expected. QOL scores may reflect physical or psychosocial functioning or distress. The choice of QOL instrument depends upon the definition, research hypothesis, cancer populat... | 18,724,538 |
History of analgesia and regional anaesthesia through philately. | Medical philately is the study of postage stamps commemorating events and pioneers in the field of medicine. In 1929, Dr Fielding H. Garrison, doyen of medical history, remarked that stamps were a great resource for the medical fraternity, something he hoped that physicians would soon recognise. His prediction has hard... | 18,724,553 |
Clinical trials in Canada: whose interests are paramount? | More than 80 percent of clinical drug trials in Canada are funded by the pharmaceutical industry. This article evaluates the overall state of clinical trials in Canada and looks at the interplay between public and private interests. Health Canada has adopted standards developed by the International Conference on Harmon... | 18,724,580 |
Clinical update: melatonin and sleep disorders. | The hormone melatonin is increasingly used for the treatment of certain sleep disorders, particularly those related to disturbed biological rhythms. This article summarises current knowledge of its mechanism of action and identifies situations where there is good evidence for its efficacy. The authors provide advice, b... | 18,724,603 |
Cardiovascular disease--the silent killer in rheumatoid arthritis. | Rheumatoid arthritis (RA) is a multisystem disease with high rates of morbidity and mortality. In recent years, there has been increasing focus on the growing rates of cardiovascular disease (CVD) in RA, over and above expected levels allowing for 'traditional' risk factors. In this paper the impact of CVD in RA, the r... | 18,724,604 |
MPs consider UK engineering's future. | The Government's Parliamentary Innovation, Universities, Science and Skills Committee (IUSSC), which in January launched an enquiry into the current "state" of the UK engineering sector, recently held a session in Westminster to hear evidence on the topic from expert bodies. IHEEM chief executive John Long was among th... | 18,724,629 |
Methodologies for determining the bioavailability and biodegradability of sludges. | The measurement of sludge bioavailability and biodegradability is important to assess the sludge potential as a source of carbon and energy during its biological stabilization. As the majority of biological sludge (secondary sludge) consists of biomass, an increase in sludge bioavailability can be achieved by using dif... | 18,724,640 |
Tretinoin microsphere gel in facial acne vulgaris: a meta-analysis. | Acne vulgaris can persist beyond adolescence into the fourth decade of life or later; most patients have a combination of inflammatory and noninflammatory lesions. To determine whether tretinoin microsphere gel (TMG) 0.04% applied once nightly is well tolerated and effective in reducing inflammatory and noninflammatory... | 18,724,648 |
Prevention of methamphetamine abuse: can existing evidence inform community prevention? | Little research exists on effective strategies to prevent methamphetamine production, distribution, sales, use, and harm. As a result, prevention practitioners (especially at the local level) have little guidance in selecting potentially effective strategies. This article presents a general causal model of methamphetam... | 18,724,655 |
[Developments of microfluidic chip-based capillary electrophoresis for protein separation]. | In this paper, the developments of microfluidic chip-based capillary electrophoresis (CE) for protein separation in recent years are reviewed. Various chip-based CE systems for protein separation based on different CE separation modes are introduced. The approaches to suppress the adsorption of proteins on the surface ... | 18,724,658 |
[Determination of monoethylglycinexylidide concentration in serum using solid phase extraction and capillary gas chromatography-mass spectrometry]. | A novel method for the determination of monoethylglycinexylidide (MEGX) (lidocaine metabolin) in serum using solid phase extraction (SPE) and capillary gas chromatography-mass spectrometry (GC-MS) was established. The serum sample was extracted with a CN-SPE column. An HP-5MS capillary column (15 m x 0.25 mm x 0.1 micr... | 18,724,665 |
[Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography]. | A high performance liquid chromatographic (HPLC) method was successfully used to separate asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb. The raw material containing 20% asiaticoside and 45% madecassoside was dissolved in methanol and used for the preparation of the pure compounds. The fl... | 18,724,677 |
[Preparation of three capsaicinoid components using preparative high performance liquid chromatography]. | A method was established for the isolation of three capsaicinoid components from capsaicinoids using preparative high performance liquid chromatography (Pre-HPLC). A preparative PRC-ODS column (250 mm x 21.5 mm, 13 microm) was used in the preparation process. By isocratic elution with methanol-water (70 : 30, v/v) as t... | 18,724,678 |
[Establishment and application of a two-dimensional liquid chromatographic system (NPLC x RPLC)]. | A two-dimensional liquid chromatographic system (NPLC x RPLC) has been developed. Normal phase liquid chromatography (NPLC) with a Hypersil SiO2 column (50 mm x 4.6 mm) was used as the first dimension, and reversed-phase liquid chromatography (RPLC) with a Kromasil C18 column (250 mm x 4.6 mm) was used as the second di... | 18,724,680 |
[Construction of adenoviral vector encoding soluble human sTNFRI-IgGFc cDNA and its expression in human airway smooth muscle cells (HASMCs)]. | Tumour necrosis factor (TNF-a) is a pro-inflammatory cytokine that has been implicated in many aspects of the airway pathology in asthma, and which has recently been highlighted as potentially important in refractory asthma. To study the feasibility of local treatment of asthma with recombinant adenovirus vector carryi... | 18,724,696 |
[Cutinase production from short-chain organic acids by Thermobifida fusca]. | We studied cutinase production from short-chain organic acids by Thermobifida fusca WSH03-11 to evaluate the possibility of converting municipal sludge to high value-added products. The optimum organic acid (8.0 g/L) and nitrogen source (1.5 g/L) concentrations were determined by the single factor experiments with buty... | 18,724,703 |
[Development and application of real-time quantitative RT- PCR assay for the detection of hepatitis E virus]. | Hepatitis E virus (HEV) sequences including four major genotypes representative strains available in GenBank were aligned with the DNAMAN software. The highly conserved internal region of ORF2 was then subjected to design primers and a probe. Furthermore, a 0.3 kb fragment of HEV ORF2 containing the amplification regio... | 18,724,714 |
[Effect of different tags on pulldown assays implemented by LMO2 fusion protein]. | Pulldown assay is an in vitro method for studies of protein-protein interactions, in which tagged proteins are usually expressed as the bait to enrich other proteins that could bind to them. In this technology, the GST tag is broadest used for its modest size and hydrophilic property. In most cases, the GST tag could i... | 18,724,713 |
An unusual trophic subsidy and species dominance in a tropical stream. | In classical theory, species are assumed to achieve dominance through competitive exclusion, but if food resources are limiting, cross-habitat trophic subsidies could also underpin dominance. The impact of dominant species on community dynamics may depend on the energy base of population size. We report on an unusual, ... | 18,724,742 |
60-day aging requirement does not ensure safety of surface-mold-ripened soft cheeses manufactured from raw or pasteurized milk when Listeria monocytogenes is introduced as a postprocessing contaminant. | Because of renewed interest in specialty cheeses, artisan and farmstead producers are manufacturing surface-mold-ripened soft cheeses from raw milk, using the 60-day holding standard (21 CFR 133.182) to achieve safety. This study compared the growth potential of Listeria monocytogenes on cheeses manufactured from raw o... | 18,724,749 |
Androgen resistance in squirrel monkeys (Saimiri spp.). | The goal of this study was to understand the basis for high androgen levels in squirrel monkeys (Saimiri spp.). Mass spectrometry was used to analyze serum testosterone, androstenedione, and dihydrotestosterone of male squirrel monkeys during the nonbreeding (n = 7) and breeding (n = 10) seasons. All hormone levels wer... | 18,724,781 |
Determination of serum creatinine by Jaffe method and how to calibrate to eliminate matrix interference problems. | The calibration of Jaffe method for serum creatinine using one serum-based standard complemented with artificial matrix compensating standard's Jaffe-interfering substances allows two-point calibration with results well comparable with enzymatic methods. Spectrophotometry was used. Jaffe procedures compensating serum/p... | 18,724,810 |
Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. | Issues related to peri-implant disease were discussed. It was observed that the most common lesions that occur, i.e. peri-implant mucositis and peri-implantitis are caused by bacteria. While the lesion of peri-implant mucositis resides in the soft tissues, peri-implantitis also affects the supporting bone. Peri-implant... | 18,724,855 |
Predictors of HIV infection and prevalence for syphilis infection among injection drug users in China: community-based surveys along major drug trafficking routes. | To assess the predictors and prevalence of HIV infection among injection drug users in highly endemic regions along major drug trafficking routes in three Chinese provinces. We enrolled participants using community outreach and peer referrals. Questionnaire-based interviews provided demographic, drug use, and sexual be... | 18,724,872 |
[mRNA expression levels of p53 and DNA damage and repair genes in peripheral blood lymphocytes of benzene-exposed workers]. | To investigate the relationship between the mRNA expression levels of p53-mediating DNA damage and repair genes in the peripheral blood lymphocytes of workers and their exposures to benzene in their working environment. The mRNA expression levels of p53 and related genes were determined by SYBR Green I chimeric fluores... | 18,724,895 |
[Knowledge of and opinions on violence against women among health professionals in specialized care]. | The aim of this study was to evaluate knowledge of gender violence among health workers/medical staff in specialized healthcare and their opinions on the subject. A further aim was to identify the organizational barriers perceived by these workers and their proposals to enhance the early detection of this phenomenon an... | 18,724,913 |
A tale of too many centrosomes. | Having the correct number of centrosomes is crucial for proper chromosome segregation during cell division and for the prevention of aneuploidy, a hallmark of many cancer cells. Several recent studies (Basto et al., 2008; Kwon et al., 2008; Yang et al., 2008) reveal the importance of mechanisms that protect against the... | 18,724,931 |
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. | Posttranslational modification of proteins with polyubiquitin occurs in diverse signaling pathways and is tightly regulated to ensure cellular homeostasis. Studies employing ubiquitin mutants suggest that the fate of polyubiquitinated proteins is determined by which lysine within ubiquitin is linked to the C terminus o... | 18,724,939 |
Computer screen photo-excited surface plasmon resonance imaging. | Angle and spectra resolved surface plasmon resonance (SPR) images of gold and silver thin films with protein deposits is demonstrated using a regular computer screen as light source and a web camera as detector. The screen provides multiple-angle illumination, p-polarized light and controlled spectral radiances to exci... | 18,724,996 |
Hospital mortality among adults admitted to and discharged from intensive care on weekends and evenings. | Patient care may be inconsistent during off hours. We sought to determine whether adults admitted to or discharged from intensive care units (ICUs) on evenings and weekends have increased mortality rates. All adults admitted to ICUs in the Calgary Health Region, Alberta, Canada, during 2000 to 2006 were included. The i... | 18,725,035 |
Polymorphism of glutathione S-transferases as genetic risk factors for the development of complications in type 2 diabetes mellitus. | Diabetes is characterized by chronic hyperglycemia that produces dysregulation of cellular metabolism and result in excess free radical production and oxidative stress. Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that work as antioxidants. Therefore, diminished expression of GSTs may resul... | 18,725,054 |
Neural networks of several novel neuropeptides involved in feeding regulation. | Novel neuropeptides acting as G-protein-coupled receptor (GPCR) ligands are known to be localized in the brain and play a range of physiologic functions, one of which is feeding regulation. We describe the distribution and localization of these recently identified GPCR ligands and review their involvement in neuronal n... | 18,725,082 |
Clinical experience shows that catastrophic late effects associated with ablative fractionation can be avoided by technological innovation. | The development of high-precision radiation therapy delivery technology has expedited a burgeoning interest in ultrabrief, intensified treatment courses that yield tumoricidal effects of unprecedented potency. Whereas novel medical treatments that provide enhanced clinical benefits can be associated with escalated risk... | 18,725,107 |
Some cases of severe normal tissue toxicity can be anticipated with ablated fractionated radiation with appropriate long-term follow-up. | As new technologies have allowed physicians to both better image and characterize malignant disease as well as deliver radiation dose with high precision and accuracy, there has been a resurgence in interest in hypofractionated or even single-fraction radiation therapy schemas. Late-reacting tissues have a low alpha/be... | 18,725,108 |
The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction. | The tool most commonly used for quantitative predictions of dose/fractionation dependencies in radiotherapy is the mechanistically based linear-quadratic (LQ) model. The LQ formalism is now almost universally used for calculating radiotherapeutic isoeffect doses for different fractionation/protraction schemes. In summa... | 18,725,109 |
Use of an acellular regenerative tissue matrix in combination with vacuum-assisted closure therapy for treatment of a diabetic foot wound. | Diabetic foot ulcers can be difficult to treat for a variety of reasons, and may result in amputation. The use of skin grafts can often be a useful method of achieving wound coverage and subsequent healing of diabetic foot ulcers; however, this method of treatment requires creation of a donor site wound that adds to th... | 18,725,123 |
Radiographic evaluation of endoscopic gastrocnemius recession, subtalar joint arthroereisis, and flexor tendon transfer for surgical correction of stage II posterior tibial tendon dysfunction: a pilot study. | The best procedure for surgical correction of stage II posterior tibial tendon dysfunction has long been a source of debate among foot and ankle surgeons. A combination of endoscopic gastrocnemius recession, subtalar joint arthroereisis, and flexor digitorum longus tendon transfer has been used in an attempt to avoid s... | 18,725,119 |
Correction of severe foot and ankle contracture due to CRPS using external fixation and pain management: report of a pediatric case. | Complex regional pain syndrome-induced dystonia is a severe deformity that can affect the lower extremities and hinder ambulation. Although a number of conservative treatments have been described for this condition, we are not aware of any publications describing the use of surgical intervention for the treatment of th... | 18,725,124 |
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