title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Kinematic assessment of paediatric forefoot varus. | Forefoot varus is a static deformity not easy to assess clinically. If left uncorrected, it is thought to affect both the posture of the patient and the kinematics of their lower limbs, and even the spine. Three-dimensional gait assessment could help to confirm forefoot varus diagnosis and provide objective evidence of... | 18,829,322 |
Alpha-tocopherol protects against oxidative damage to lipids of the rod outer segments of the equine retina. | Oxidative stress is a possible risk factor for eye diseases. Lipid peroxidation is one of the major events induced by oxidative stress and is particularly active in polyunsaturated fatty acid (PUFA)-rich biomembranes. This work evaluated endogenous lipid antioxidants, in vitro non-enzymatic lipid peroxidation of rod ou... | 18,829,353 |
Salmonella: the pelvic masquerader. | Salmonella sp is a significant cause of morbidity and mortality. Although commonly infecting the gastrointestinal system, other presentations are not unheard of. Salmonella is an unlikely and an unusual cause of genital tract infection. We describe a woman with suspected pelvic inflammatory disease eventually confirmed... | 18,829,361 |
Model analysis of local oxygen delivery with liposome-encapsulated hemoglobin. | Liposome-encapsulated hemoglobins (LHs) are comparable to red blood cells (RBCs) in terms of oxygen (O(2))-carrying capacity. The smaller particle size of LHs than of platelets allows their homogeneous dispersion in circulating plasma. In this study, we evaluated the effect of LH transfusion on arterial O(2) delivery t... | 18,829,372 |
Glucosidase-beta variations and Lewy body disorders. | It has been proposed that there is an increased frequency of glucosidase-beta mutations in Lewy body disorders. Our comprehensive DNA sequencing approach found a small number of glucosidase-beta mutations in 101 neuropathologically defined Lewy body disease cases (3%) compared to 99 healthy post-mortem controls (1%); o... | 18,829,375 |
Mixed respiratory virus infections. | Mixed respiratory viral infections are double negative common and evidence that they are associated with severe disease is supported by some groups. This controversial observation can be explained by the lack of sensitivity of the assessed methods used for viral identification and by the small number of patients includ... | 18,829,380 |
Immune-mediated neuropathies in myeloma patients treated with bortezomib. | Bortezomib is a new chemotherapeutic drug available for the treatment of lymphoid disorders, including multiple myeloma. Although its primary mechanism of action is proteasome inhibition, other mechanisms can contribute to the therapeutic effects, including modulation of inflammatory cytokines and immune response. One ... | 18,829,381 |
Targeting of albumin-embedded paclitaxel nanoparticles to tumors. | We have used tumor-homing peptides to target abraxane, a clinically approved paclitaxel-albumin nanoparticle, to tumors in mice. The targeting was accomplished with two peptides, CREKA and LyP-1 (CGNKRTRGC). Fluorescein (FAM)-labeled CREKA-abraxane, when injected intravenously into mice bearing MDA-MB-435 human cancer ... | 18,829,396 |
Electrical characterization of hydroxyapatite-based bioceramics. | This paper studies the AC conductivity and permittivity of hydroxyapatite (HA)-based ceramics from 0.1 Hz-1 MHz at temperatures from room temperature to 1000 degrees C. HA-based ceramics were prepared either as dense ceramics or in porous form with interconnected porosity and were sintered in either air or water vapour... | 18,829,403 |
How academic psychiatry can better prepare students for their future patients. Part I: the failure to recognize depression and risk for suicide in primary care; problem identification, responsibility, and solutions. | The author, after a review of the relevant literature, found that depression and the risk for suicide remain unacceptably underrecognized in primary care (PC). The negative consequences are substantial for patients and their physicians. Suicide prevention in PC begins with the recognition of depression because suicide ... | 18,829,423 |
The role of the striatum in aversive learning and aversive prediction errors. | Neuroeconomic studies of decision making have emphasized reward learning as critical in the representation of value-driven choice behaviour. However, it is readily apparent that punishment and aversive learning are also significant factors in motivating decisions and actions. In this paper, we review the role of the st... | 18,829,426 |
The role of social cognition in decision making. | Successful decision making in a social setting depends on our ability to understand the intentions, emotions and beliefs of others. The mirror system allows us to understand other people's motor actions and action intentions. 'Empathy' allows us to understand and share emotions and sensations with others. 'Theory of mi... | 18,829,429 |
Congenital abnormalities and acute leukemia among children with Down syndrome: a Children's Oncology Group study. | Children with Down syndrome, due to their heightened risk of leukemia and increased prevalence of congenital abnormalities, comprise a valuable population in which to study etiology. A Children's Oncology Group study investigated the causes of childhood leukemia in children with Down syndrome diagnosed at ages 0 to 19 ... | 18,829,445 |
Expression of epithelial cadherin in the human male reproductive tract and gametes and evidence of its participation in fertilization. | Epithelial cadherin (E-cadherin) has been involved in several calcium-dependent cell-cell adhesion events; however, its participation in gamete interaction has not been fully investigated. Our results have demonstrated expression of E-cadherin mRNA in the human male reproductive tract showing higher levels in the caput... | 18,829,448 |
Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers. | 5-Azacytidine (5-AZA) is a DNA-hypomethylating agent. Valproic acid is a histone deacetylase inhibitor. Combining hypomethylating agents and histone deacetylase inhibitors produces synergistic anticancer activity in vitro and in vivo. On the basis of this evidence, we conducted a phase I study of the combination of 5-A... | 18,829,512 |
Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance. | Pancreatic cancer--a tumor displaying a particularly abundant stromal reaction--is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression. Characterization of the mecha... | 18,829,522 |
The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. | Side population (SP) cell analysis and sorting have been successfully applied to hepatocellular carcinoma (HCC) cell lines to identify a minor cell population with cancer stem cell properties. However, the molecular mechanisms operating in SP cells remain unclear. The polycomb gene product BMI1 plays a central role in ... | 18,829,528 |
Prolyl isomerase cyclophilin A regulation of Janus-activated kinase 2 and the progression of human breast cancer. | The activation of the Janus-activated kinase 2 (Jak2) tyrosine kinase following ligand binding has remained incompletely characterized at the mechanistic level. We report that the peptidyl-prolyl isomerase (PPI) cyclophilin A (CypA), which is implicated in the regulation of protein conformation, is necessary for the pr... | 18,829,531 |
Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor. | This study identifies a novel cross-talk paradigm between the type I insulin-like growth factor receptor (IGF1R) and epidermal growth factor receptor (EGFR) in colon cancer cells. IGF1R activation by ligand exposure in growth factor-deprived cells induces Akt activation in the FET, CBS, and GEO colon cancer cell lines.... | 18,829,558 |
The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis. | Tumor cells frequently exhibit decreased adhesiveness due to failure to deposit stromal fibronectin (FN), permitting more rapid proliferation, migration, invasion, and metastasis. Although up-regulation of FN has been noted in gene profiles of carcinomas compared with normal tissue, reduced FN expression has been descr... | 18,829,569 |
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. | Much recent effort has focused on identifying and characterizing cellular markers that distinguish tumor propagating cells (TPC) from more differentiated progeny. We report here an unusual promoter DNA methylation pattern for one such marker, the cell surface antigen CD133 (Prominin 1). This protein has been extensivel... | 18,829,568 |
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. | MicroRNA dysregulation is observed in different types of cancer. MiR-21 up-regulation has been reported for the majority of cancers profiled to date; however, knowledge is limited on the mechanism of action of miR-21, including identification of functionally important targets that contribute to its proproliferative and... | 18,829,576 |
Exogenous irritant-induced airway hyperreactivity and inhibition of soluble guanylyl cyclase. | The majority of nitric oxide (NO) effects in the respiratory system are caused by stimulation of soluble guanylyl cyclase (sGC) with subsequent increase of cyclic guanosine monophosphate (cGMP) production. The importance of this mechanism of NO action in airway hyperreactivity (AHR) pathogenesis is unknown. Therefore, ... | 18,829,592 |
Radiofrequency energy delivery to the lower esophageal sphincter (Stretta procedure) does not provide long-term symptom control. | The Stretta procedure (radiofrequency energy application to the lower esophageal sphincter) is a unique endoluminal technique for the management of gastroesophageal reflux. This article reports on the long-term effectiveness of the Stretta procedure in patients with significant gastroesophageal reflux disease (GERD) re... | 18,829,607 |
Mortality and diabetes mellitus in amputations of the lower limbs for gas gangrene: a case report. | The aim of this study was to examine any association between the presence of diabetes in patients with gas gangrene of the legs and mortality following major lower limb amputation. In a retrospective study, patients submitted to amputation of lower limbs for anaerobic infections were evaluated in the period from Januar... | 18,829,608 |
Triple risk: do difficult temperament and family conflict increase the likelihood of behavioral maladjustment in children born low birth weight and preterm? | This study examined the impact of family conflict on internalizing and externalizing behavior at age 8 for children born low birth weight (LBW) and preterm (PT), with specific attention to the moderating role of early temperament. The sample included 728 families enrolled in the longitudinal study of the Infant Health ... | 18,829,612 |
Neural respiratory drive in healthy subjects and in COPD. | The aim of the present study was to use the diaphragm electromyogram (EMG(di)) to compare levels of neural respiratory drive (NRD) in a cohort of healthy subjects and chronic obstructive pulmonary disease (COPD) patients, and to investigate the relationship between NRD and pulmonary function in COPD. EMG(di) was record... | 18,829,678 |
Hypothalamic involvement in Huntington's disease: an in vivo PET study. | Recent studies have shown alterations in metabolism, sleep and circadian rhythms as well as in several neuropeptides derived from the hypothalamic-pituitary axis in Huntington's disease patients; however, the pathology underlying these abnormalities is not known. Our aim was to assess in vivo D(2) receptor's loss/dysfu... | 18,829,696 |
Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer. | To identify using proteomic analysis, proteins of altered abundance in the skin of patients with SSc. 4 mm excision biopsies were obtained from the forearm involved skin of 12 diffuse SSc patients and 12 healthy controls. Two-dimensional gel electrophoresis was used to separate and define proteins in normal and SSc ski... | 18,829,709 |
S-adenosyl homocysteine-induced hyperpolyadenylation of vesicular stomatitis virus mRNA requires the methyltransferase activity of L protein. | There are many unique aspects of vesicular stomatitis virus (VSV) transcription. In addition to its unusual mRNA capping and methyltransferase mechanisms, the addition of S-adenosyl homocysteine (SAH), which is the by-product and competitive inhibitor of S-adenosyl methionine (SAM)-mediated methyltransferase reactions,... | 18,829,753 |
Experimental evolution of human influenza virus H3 hemagglutinin in the mouse lung identifies adaptive regions in HA1 and HA2. | The genetic basis for virulence and host switching in influenza A viruses (FLUAV) is largely unknown. Because the hemagglutinin (HA) protein is a determinant of these properties, HA evolution was mapped in an experimental model of mouse lung adaptation. Variants of prototype A/Hong Kong/1/68 (H3N2) (wild-type [wt] HK) ... | 18,829,764 |
Systematic review of digital imaging screening strategies for retinopathy of prematurity. | Retinal imaging with remote interpretation could decrease the number of diagnostic eye examinations that premature infants need for the detection of retinopathy of prematurity and thus decrease the time demand on the relatively small pool of ophthalmologists who perform retinopathy of prematurity examinations. Our goal... | 18,829,807 |
Medical emergencies occurring at school. | Children and adults might experience medical emergency situations because of injuries, complications of chronic health conditions, or unexpected major illnesses that occur in schools. In February 2001, the American Academy of Pediatrics issued a policy statement titled "Guidelines for Emergency Medical Care in Schools"... | 18,829,817 |
Toward optimal target placement for neural prosthetic devices. | Neural prosthetic systems have been designed to estimate continuous reach trajectories (motor prostheses) and to predict discrete reach targets (communication prostheses). In the latter case, reach targets are typically decoded from neural spiking activity during an instructed delay period before the reach begins. Such... | 18,829,845 |
Munc18a scaffolds SNARE assembly to promote membrane fusion. | Munc18a is an SM protein required for SNARE-mediated fusion. The molecular details of how Munc18a acts to enhance neurosecretion have remained elusive. Here, we use in vitro fusion assays to characterize how specific interactions between Munc18a and the neuronal SNAREs enhance the rate and extent of fusion. We show tha... | 18,829,865 |
Patients with workers' compensation claims have worse outcomes after rotator cuff repair. | Previous studies have demonstrated varying correlations between Workers' Compensation status and the outcome of rotator cuff repair. However, none of those studies have formally accounted for potential confounding factors with multivariable analysis. We hypothesized that patients with Workers' Compensation claims who u... | 18,829,907 |
Prophylactic bypass grafting and long-term bracing in the management of anterolateral bowing of the tibia and neurofibromatosis-1. | Congenital anterolateral bowing of the tibia is a pre-pseudarthrosis stage of congenital pseudarthrosis of the tibia and is associated with a substantial risk of fracture and pseudarthrosis. We evaluated the results of prophylactic bypass grafting performed in combination with bracing to prevent fracture and pseudarthr... | 18,829,910 |
Surgical treatment of calcaneal deformity in a select group of patients with myelomeningocele. | The surgical treatment of calcaneal deformity in patients with myelomeningocele has not been uniformly successful in correcting the deformity and preventing recurrence. The purpose of the present study was to examine the results of posterior transfer of the anterior tibial tendon with concurrent procedures in an attemp... | 18,829,913 |
Distal tibial reconstruction with use of a circular external fixator and an intramedullary nail. Surgical technique. | Distal tibial reconstruction with use of an external fixator when there is bone loss, limb-length discrepancy, and/or ankle instability is associated with many problems. The technique of limb-lengthening, ankle arthrodesis, and segmental transfer over an intramedullary nail has been introduced to overcome these problem... | 18,829,932 |
Drosophila painless is a Ca2+-requiring channel activated by noxious heat. | Thermal changes activate some members of the transient receptor potential (TRP) ion channel super family. They are primary sensors for detecting environmental temperatures. The Drosophila TRP channel Painless is believed responsible for avoidance of noxious heat because painless mutant flies display defects in heat sen... | 18,829,951 |
Perceptual systems controlling speech production. | It is proposed that the acquisition and maintenance of fluent speech depend on the rapid temporal integration of motor feedforward and polysensory (auditory and somatosensory) feedback signals. In a functional magnetic resonance imaging study on 21 healthy right-handed, English-speaking volunteers, we investigated acti... | 18,829,954 |
Does learned shape selectivity in inferior temporal cortex automatically generalize across retinal position? | Biological visual systems have the remarkable ability to recognize objects despite confounding factors such as object position, size, pose, and lighting. In primates, this ability likely results from neuronal responses at the highest stage of the ventral visual stream [inferior temporal cortex (IT)] that signal object ... | 18,829,962 |
A local circuit model of learned striatal and dopamine cell responses under probabilistic schedules of reward. | Recently, dopamine (DA) neurons of the substantia nigra pars compacta (SNc) were found to exhibit sustained responses related to reward uncertainty, in addition to the phasic responses related to reward-prediction errors (RPEs). Thus, cue-dependent anticipations of the timing, magnitude, and uncertainty of rewards are ... | 18,829,964 |
Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. | Many of the effects of angiotensin (Ang) II are mediated through specific plasma membrane receptors. However, Ang II also elicits biological effects from the interior of the cell (intracrine), some of which are not inhibited by Ang receptor blockers (ARBs). Recent in vitro studies have identified high glucose as a pote... | 18,829,990 |
Thermodynamic properties of blood plasma of patient suffering from atherosclerosis. | The goal of the work is to find out the changes in the heat parameters of blood plasma denaturation of a son and a granddaughter, in comparison with the same parameters of a 91 years old grandfather with atherosclerosis. The significant changes in heat (Q(d)) and denaturation temperature (T(d)) of albumin, globulins an... | 18,830,024 |
[Calcitonin]. | Calcitonin is a polypeptide hormone that bone resorption-inhibitory and analgesic effects, and has been used over many decades as a drug for the treatment of osteoporosis in Japan and overseas. Reports of large-scale studies of this hormone therefore as yet are few, compared to recently introduced drugs. Calcitonin is ... | 18,830,043 |
High levels of antibodies to Plasmodium falciparum liver stage antigen-1 in naturally infected individuals in Myanmar. | Plasmodium falciparum liver stage antigen-1 (PfLSA-1) is one of the few antigens expressed exclusively in liver stage parasites. In this study, we evaluated the antibody responses against recombinant PfLSA-1 in naturally infected individuals in Myanmar. High levels of antibody responses (70.7%) were detected in 82 seru... | 18,830,063 |
Contemporary management of fibromuscular dysplasia. | Fibromuscular dysplasia is an underdiagnosed and misunderstood disease. The purpose of this review is to inform healthcare providers and the public about a condition that may be more common than previously thought. There has been little new information published about fibromuscular dysplasia in the past 30 years. The I... | 18,830,066 |
Predicting outcomes in cardiac surgery: risk stratification matters? | To illustrate the limitations of predictive risk models in cardiac surgery, highlight the difficulty in interpreting risk-adjusted outcome analysis and discuss the challenges of making clinical decisions based on risk predictions, particularly in high-risk patients. Predictive risk models developed after logistic regre... | 18,830,070 |
Intraoperative coronary graft assessment. | Intraoperative graft assessment in coronary artery bypass grafting is infrequently performed. Nevertheless, studies show an immediate graft closure rate of 5-9% and a 1-year closure rate of 20-30%. Coronary angiography is the 'gold standard' for graft assessment yet has been seldom employed because of logistical proble... | 18,830,071 |
Distribution of body fat and risk of coronary heart disease in men and women. | Earlier studies investigating the risk of developing coronary heart disease in relation to body fat distribution showed inconsistent results, and any sex-related difference in disease risk has not been adequately examined. This review aims to assess current findings on the prospective association between body fat distr... | 18,830,075 |
A customized genetic approach to the number one killer: coronary artery disease. | To review the evidence supporting genetic predisposition to coronary artery disease (CAD). Secondly, to elucidate the barriers precluding the identification of genes responsible for CAD. Thirdly, to indicate the new technology now available to overcome these barriers and summarize current progress. Evidence strongly su... | 18,830,080 |
Left atrial calcifications: computed tomographic imaging findings of an unusual sign of rheumatic heart disease. | Left atrial wall calcifications are an extremely rare finding of unknown cause usually associated with rheumatic disease. Only a few case reports of this entity are found in the literature, mostly describing the findings on conventional chest radiography, echocardiography, and angiography. To the best of our knowledge,... | 18,830,099 |
Craniofacial melorheostosis. | Melorheostosis is a rare benign disease of cortical bone most frequently presenting as peripheral hyperostosis with a characteristic "melting wax" appearance on conventional radiographs. The disease most frequently affects the appendicular skeleton and is seen only rarely in the craniofacial bones. We discuss a case of... | 18,830,120 |
Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor. | Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and dehydrocorybulbine. The tertiary alkaloids were further analyzed by chiral HPLC to deter... | 18,830,156 |
Spontaneous rib fractures in a black woman with familial hypocalciuric hypercalcemia. | Familial hypocalciuric hypercalcemia (FHH) is a rare but important consideration in the differential diagnosis of hypercalcemia. FHH results from an autosomal dominantly inherited inactivating mutation of the calcium sensing receptor (CaSR) gene and is typically associated with a benign clinical course and normal bone ... | 18,830,196 |
Rehabilitation of an artist after right-hemisphere stroke. | Traditionally, in both medicine and neuropsychology, symptoms are defined as significant deviations in a given parameter from a "physiological" norm largely based on statistical studies of large populations. Thus the goal of rehabilitation is to bring the patient's performance within the bounds of acceptable variation ... | 18,830,198 |
Squeezing and entanglement in a Bose-Einstein condensate. | Entanglement, a key feature of quantum mechanics, is a resource that allows the improvement of precision measurements beyond the conventional bound attainable by classical means. This results in the standard quantum limit, which is reached in today's best available sensors of various quantities such as time and positio... | 18,830,245 |
PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. | Adult T-cell leukemia/lymphoma (ATLL) develops after infection with human T-cell leukemia virus-1 (HTLV-1) after a long latency period. The negative regulatory programmed death-1/programmed death-1 ligand 1 (PD-1/PD-L1) pathway has been implicated in the induction of cytotoxic T-lymphocyte (CTL) exhaustion during chron... | 18,830,259 |
Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis. | IL-17F is known to be involved in many inflammatory diseases, but its role in skin diseases has not been fully examined. Because IL-8 is involved in many skin diseases such as psoriasis, we investigated the production of IL-8 in normal human epidermal keratinocytes (NHEKs) stimulated by IL-17F, tumor necrosis factor-al... | 18,830,271 |
Quantitative comparison of quadratic covariance-based anomalous change detectors. | Simulations applied to hyperspectral imagery from the AVIRIS sensor are employed to quantitatively evaluate the performance of anomalous change detection algorithms. The evaluation methodology reflects the aim of these algorithms, which is to distinguish actual anomalous changes in a pair of images from the incidental ... | 18,830,282 |
Design and fabrication of a low-cost, multispectral imaging system. | This paper reports the design and construction of a low-cost, multispectral imaging system using a single, large format CCD and an array of 18 individual lenses coupled to individual spectral filters. The system allows the simultaneous acquisition of 18 subimages, each with potentially different optical information. Th... | 18,830,286 |
Narrowband optical filters suitable for various applications in optical communications. | We propose three types of narrowband optical filters based on a Fox-Smith resonator. We demonstrate that by choosing the appropriate combination of coating materials on each prism facet, one can design either a high reflectance or a high transmittance optical filter, suitable for low bit rate optical communication appl... | 18,830,303 |
Propagation of a random electromagnetic beam through a misaligned optical system in turbulent atmosphere. | On the basis of the generalized diffraction integral formula for misaligned optical systems in the spatial domain, an analytical propagation expression for the elements of the cross-spectral density matrix of a random electromagnetic beam passing through a misaligned optical system in turbulent atmosphere is derived. S... | 18,830,318 |
Evaluation and unification of some methods for estimating reflectance spectra from RGB images. | The problem of estimating spectral reflectances from the responses of a digital camera has received considerable attention recently. This problem can be cast as a regularized regression problem or as a statistical inversion problem. We discuss some previously suggested estimation methods based on critically undersample... | 18,830,322 |
Scattering by a dense finite layer of infinite cylinders at oblique incidence. | This paper presents the scattering solution for a finite dense layer of cylinders irradiated by an arbitrarily polarized plane wave at a general incident direction. The theoretical formulation utilizes the effective field approach and quasi-crystalline approximation to derive the governing equations for the propagation... | 18,830,327 |
Velocity of heat dissipative solitons in optical fibers. | In the fiber fuse, a pulse of high temperature travels toward the input end of the fiber, where high-power laser light is launched into the fiber. At any point along the fiber, the soliton can be ignited. The fiber core is damaged in the process so that light cannot propagate beyond the hot spot. This phenomenon is an ... | 18,830,343 |
Spectroscopy and femtosecond laser performance of Yb3+:YAlO3 crystal. | We report what we believe to be the first demonstration of cw and passively mode-locked Yb(3+):YAlO(3) (Yb:YAP) laser operation under diode pumping. Spectroscopic properties of a 0.6 at.%Yb(3+)-doped YAP single crystal were investigated. Output power up to 1.2 W with slope efficiency of 64.5% in the cw regime and 225 f... | 18,830,349 |
Quantum electrodynamics analysis of optical binding in counterpropagating beams and effect of particle size. | A general expression for optical binding energy between particles of any size, in counterpropagating beams with and without interference, is derived using quantum electrodynamics. The effect of particle size on the optically induced interparticle energy surface, which has been the subject of recent research, is explore... | 18,830,350 |
Electrically tunable Sagnac filter based on a photonic bandgap fiber with liquid crystal infused. | We demonstrate an electrically tunable Sagnac filter based on a photonic bandgap fiber that is realized by infusing liquid crystal into a solid-core air-hole photonic crystal fiber. The filter enables an electrical tuning with a range of about 26 nm for one single interference minimum in the transmission bandgap from 1... | 18,830,356 |
High-repetition-rate, 491 MHz, femtosecond fiber laser with low timing jitter. | We demonstrate a soliton fiber laser based on an anomalously dispersive erbium-doped fiber butt-coupled to a saturable absorber mirror for passive mode locking. The laser generates 180 fs pulses at a repetition rate of 491 MHz and exhibits a timing jitter as low as 20 fs over the frequency range 1 kHz-10 MHz. | 18,830,358 |
Biomimetic subwavelength antireflective gratings on GaAs. | We have developed a simple and scalable bottom-up approach for fabricating moth-eye antireflective coatings on GaAs substrates. Monolayer, non-close-packed silica colloidal crystals are created on crystalline GaAs wafers by a spin-coating-based single-layer reduction technique. These colloidal monolayers can be used as... | 18,830,359 |
Prevention of decoherence by two femtosecond chirped pulse trains. | We study the vibrational energy relaxation (VER) and collisional dephasing as channels of coherence loss in a vibrational mode that is selectively excited using chirped pulse adiabatic passage in the Raman configuration. Based on the dressed state picture analysis we propose a method to reduce decoherence using femtose... | 18,830,366 |
Time-resolved single-photon detection by femtosecond upconversion. | We demonstrate a time-resolved single-photon detection technique based on ultrafast sum-frequency generation, providing femtosecond measurement capability for single photons in photonic quantum information processing. Noncollinear broadband upconversion in periodically poled MgO-doped stoichiometric lithium tantalate w... | 18,830,370 |
Endocervicosis of the bladder: report of a case and review of the current literature. | An important variety of metaplastic lesions of the urinary bladder have been reported in the medical literature up to date. Among those of Müllerian origin, endocervicosis is the most infrequent. We report a 67 years old woman who presented with a history of left flank pain and dysuria for the past 2 months. Imaging st... | 18,830,389 |
Cost-effectiveness analysis for trigeminal neuralgia: Cyberknife vs microvascular decompression. | We present the preliminary results of a cost-effectiveness analysis of cyberknife radiosurgery (CKR) versus microvascular decompression (MVD) for patients with medically unresponsive trigeminal neuralgia. Direct healthcare costs from hospital's perspective attributable to CKR and MVD were collected. Pain level caused b... | 18,830,392 |
Evolution of the aging brain transcriptome and synaptic regulation. | Alzheimer's disease and other neurodegenerative disorders of aging are characterized by clinical and pathological features that are relatively specific to humans. To obtain greater insight into how brain aging has evolved, we compared age-related gene expression changes in the cortex of humans, rhesus macaques, and mic... | 18,830,410 |
PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. | Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein deletion and subsequent activation of the PI3K/Akt signaling pathway are common in cancer. Here we show that PTEN inactivation in human T cell acute lymphoblastic leukemia (T-ALL) cells is not always synonymous with PTEN gene lesions an... | 18,830,414 |
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. | Based on extensive preclinical data, glycogen synthase kinase-3 (GSK-3) has been proposed to be a viable drug target for a wide variety of disease states, ranging from diabetes to bipolar disorder. Since these new drugs, which will be more powerful GSK-3 inhibitors than lithium, may potentially be given to women of chi... | 18,830,417 |
Dominican Children with HIV not Receiving Antiretrovirals: Massage Therapy Influences their Behavior and Development. | Forty-eight children (M age = 4.8 years) infected with HIV/AIDS and living in the Dominican Republic were randomly assigned to a massage therapy or a play session control group. The children in the massage therapy group received two weekly 20-min massages for 12 weeks; the children in the control group participated in ... | 18,830,444 |
Temperature-triggered gate opening for gas adsorption in microporous manganese formate. | Microporous manganese formate shows temperature-triggered gate opening for nitrogen and argon adsorption, which is not due to a structural change of the framework but due to dynamic opening of the pore aperture and/or sufficient kinetic energy of the adsorbates to overcome a diffusion barrier above a critical temperatu... | 18,830,463 |
Total syntheses of (+/-)-montanin A and (+/-)-teuscorolide. | The first total syntheses of (+/-)-montanin A and (+/-)-teuscorolide have been achieved from an advanced precursor previously developed via a Diels-Alder strategy; in the synthetic sequence, the synthesis of montanin A was first accomplished in 8 steps, from which teuscorolide was readily achieved in 2 steps by using a... | 18,830,471 |
Lysine and arginine residues do not increase the helicity of alanine-rich peptide helices. | The helix-disfavoring, versus alanine, propagation values of lysine (0.8) and arginine (1.0) residues placed centrally in an (Ala)(9) unit have been measured by (13)C NMR. | 18,830,486 |
Auto-hydroxylation of FIH-1: an Fe(ii), alpha-ketoglutarate-dependent human hypoxia sensor. | HIF-asparaginyl hydroxylase (FIH-1) normally couples O(2)-activation to hydroxylation of Asn(803) on the alpha-subunit of the hypoxia-inducible factor (HIFalpha), a key step in pO(2) sensing; in the absence of HIFalpha, O(2)-activation becomes uncoupled, leading to self-hydroxylation at Trp(296) and a purple Fe(iii)-O-... | 18,830,487 |
Copper nanoparticles on hydrotalcite as a heterogeneous catalyst for oxidant-free dehydrogenation of alcohols. | We have developed a highly efficient heterogeneous catalytic system using hydrotalcite-supported Cu nanoparticles (Cu/HT) that can successfully promote the oxidant-free dehydrogenation of various alcohols under liquid-phase conditions. | 18,830,499 |
Gold-catalyzed efficient tandem assembly of terminal alkynes and arynes: synthesis of alkynylated biphenyl derivatives. | Gold catalysts have been found to catalyze the tandem assembly of arynes and terminal alkynes efficiently in the presence of CuI under mild reaction conditions to provide useful alkynylated biphenyl derivatives. | 18,830,501 |
Bromine-lithium exchange under non-cryogenic conditions: TMSCH(2)Li-LiDMAE promoted C-2 lithiation of 2,3-dibromopyridine. | The first C-2 selective bromine-lithium exchange in 2,3-dibromopyridine was performed at 0 degrees C in toluene using the TMSCH(2)Li-LiDMAE reagent. | 18,830,502 |
Home medicine chests and their relationship with self-medication in children and adolescents. | To investigate the contents of home medicine chests and their relationship with self-medication in children and adolescents in the towns of Limeira and Piracicaba, SP, Brazil. This is a descriptive population study based on a home survey of a simple random sample from both towns, comprising 705 households from census s... | 18,830,513 |
How frequently are physiological variables recorded in the emergency room in patients with obstructive pulmonary diseases and pneumonia? | To assess how frequently measurements of relevant physiological variables are made in patients presenting acutely to hospital with obstructive pulmonary diseases (OPD) and pneumonia. Patients admitted to three hospitals in western Norway with OPD (asthma or chronic obstructive pulmonary disease (COPD)) and/or pneumonia... | 18,830,520 |
Bilateral tarsometatarsal fracture-dislocations: a missed work-related injury. | Tarsometatarsal (Lisfranc) fracture-dislocation is an uncommon foot injury. Subtle injuries are more difficult to diagnose though they cause serious morbidity. Bilateral subtle tarsometatarsal injury has not been reported before. We report bilateral subtle tarsometatarsal dislocations that were caused by a work-related... | 18,830,527 |
Adrenal cavernous haemangioma. | The adrenal gland is a rare location for haemangioma. Approximately 52 surgical cases have been reported in the literature. We report a huge non-functioning adrenal haemangioma presenting in a 50-year-old woman with flank pain. This was illustrated by computed tomography. It was surgically removed and diagnosed postope... | 18,830,528 |
Arterial pressure changes during the Valsalva maneuver to predict fluid responsiveness in spontaneously breathing patients. | To evaluate whether arterial pressure response during a Valsalva maneuver could predict fluid responsiveness in spontaneously breathing patients. Prospective clinical study in a 17-bed multidisciplinary intensive care unit. Thirty patients without mechanical ventilation and equipped with a radial arterial catheter for ... | 18,830,578 |
Inter-limb transfer of learned ankle movements. | Inter-limb learning transfer (ILT) between the upper-limbs has been well documented, but no corresponding study of the lower limbs has been done. We investigated ILT in the lower limbs of subjects who learned to move a cursor toward targets within 800 ms using ankle movements: plantar/dorsi-flexion and inversion/eversi... | 18,830,590 |
Expression of cGMP signaling elements in the Grueneberg ganglion. | The Grueneberg ganglion (GG) is a cluster of neurons localized to the vestibule of the anterior nasal cavity. Based on axonal projections to the olfactory bulb of the brain, as well as expression of olfactory receptors and the olfactory marker protein, it is considered a chemosensory subsystem. Recently, it was observe... | 18,830,617 |
Investigating differentiation mechanisms of the constituent cells of sex cord-stromal tumours of the ovary. | SOX-9, an essential factor for male sexual development, can be induced by prostaglandin D2 in a Sry-independent mechanism. Recent data suggest that the hedgehog pathway is involved in the differentiation of normal Sertoli and Leydig cells. The purpose of our study was to investigate the mechanisms involved in the diffe... | 18,830,622 |
Current practices in performing frozen sections for thyroid and parathyroid pathology. | In this review article, current trends in thyroid and parathyroid frozen sections are discussed. In Japan and other countries, the numbers of thyroid frozen sections have been dramatically decreasing over the past decade. The decline in the number of thyroid frozen sections has been attributed to two major factors: hig... | 18,830,623 |
Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma. | Recently, functional cannabinoid receptor-1 (CB1) and vanilloid receptor-1 (TRPV1) have been described in human prostate and prostate cancer-derived cell lines where the activation of the receptors resulted in inhibition of cellular growth. We, however, lack the description of the expression of these molecules in human... | 18,830,626 |
Cetuximab enhances the efficacy of bortezomib in squamous cell carcinoma cell lines. | Proteasome inhibition has been shown to be effective in multiple myeloma and solid tumor models. In this in vitro study, we investigated the antitumor effect of bortezomib (Velcade) in combination with cetuximab in squamous cell carcinoma cell lines (SCC). Dose-escalation studies were performed in five squamous cell ca... | 18,830,627 |
Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of ataxia telangiectasia and Werner syndrome fibroblasts. | The premature ageing ataxia telangiectasia (AT) and Werner syndromes (WS) are associated with accelerated cellular ageing. Young WS fibroblasts have an aged appearance and activated p38 MAP kinase, and treatment with the p38 inhibitor SB230580 extends their lifespan to within the normal range. SB203580 also extends the... | 18,830,681 |
Variability of the mitochondrial SSU rDNA of Nomuraea species and other entomopathogenic fungi from hypocreales. | Hypocrealean arthropod pathogenic fungi have profound impact on the regulation of agricultural and medical pests. However, until now the genetic and phylogenetic relationships among species have not been clarified, such studies could clarify host specificity relationships and define species boundaries. Our purpose was ... | 18,830,688 |
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