title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors. | Induced pluripotent stem cell technology, also termed iPS, is an emerging approach to reprogram cells into an embryonic stem cell-like state by viral transduction with defined combinations of factors. iPS cells share most characteristics of embryonic stem cells, counting pluripotency and self-renewal, and have so far b... | 18,826,945 |
The transcriptional coactivators SAGA, SWI/SNF, and mediator make distinct contributions to activation of glucose-repressed genes. | The paradigm of activation via ordered recruitment has evolved into a complicated picture as the influence of coactivators and chromatin structures on gene regulation becomes understood. We present here a comprehensive study of many elements of activation of ADH2 and FBP1, two glucose-regulated genes. We identify SWI/S... | 18,826,948 |
An activin/furin regulatory loop modulates the processing and secretion of inhibin alpha- and betaB-subunit dimers in pituitary gonadotrope cells. | Of all ligands of the transforming growth factor beta superfamily, inhibins and activins are a physiologically relevant pair that are functional antagonists of each other. Activin stimulates whereas inhibin blocks follicle-stimulating hormone biosynthesis and secretion from pituitary gonadotrope cells, and together, in... | 18,826,955 |
Usher syndrome and Leber congenital amaurosis are molecularly linked via a novel isoform of the centrosomal ninein-like protein. | Usher syndrome (USH) and Leber congenital amaurosis (LCA) are autosomal recessive disorders resulting in syndromic and non-syndromic forms of blindness. In order to gain insight into the pathogenic mechanisms underlying retinal degeneration, we searched for interacting proteins of USH2A isoform B (USH2A(isoB)) and the ... | 18,826,961 |
After the master settlement agreement: targeting and exposure of youth to magazine tobacco advertising. | Targeting and exposure of youth to magazine advertising of tobacco products is associated with increased smoking initiation. National magazine advertising and youth exposure declined in the period following the Master Settlement Agreement (MSA). However, tobacco companies continued targeting youth with brands that were... | 18,826,968 |
Co-morbidity obese children in family practice in The Netherlands: the results of a pilot study. | The aim of this pilot study was to assess the prevalence of co-morbidity in obese children. Particular emphasis was on cardiovascular risk. In this retrospective, cross-sectional, observational study the data of 155 obese children, who visited a paediatric obesity outdoor clinic, have been studied. In all, 92% of the p... | 18,826,992 |
Familial risks for hospitalization with endocrine diseases. | Familial clustering of a disease is an indicator of a possible heritable cause. In the era of genome scans, the consideration of data on heritability should be important in the assessment of the likely success of the scans. The objective of the study was to carry out a family study on nonthyroid endocrine diseases to s... | 18,827,002 |
Vitamin D receptor genotype in hypophosphatemic rickets as a predictor of growth and response to treatment. | Treatment of X-linked hypophosphatemic rickets improves bone mineralization and bone deformities, but its effect on skeletal growth is highly variable. Genetic variants in the promoter region of the vitamin D receptor (VDR) gene may explain the response to treatment because this receptor mediates vitamin D action. We s... | 18,827,005 |
Myofibroblast communication is controlled by intercellular mechanical coupling. | Neoformation of intercellular adherens junctions accompanies the differentiation of fibroblasts into contractile myofibroblasts, a key event during development of fibrosis and in wound healing. We have previously shown that intercellular mechanical coupling of stress fibres via adherens junctions improves contraction o... | 18,827,018 |
How does increasingly plainer cigarette packaging influence adult smokers' perceptions about brand image? An experimental study. | Cigarette packaging is a key marketing strategy for promoting brand image. Plain packaging has been proposed to limit brand image, but tobacco companies would resist removal of branding design elements. A 3 (brand types) x 4 (degree of plain packaging) between-subject experimental design was used, using an internet onl... | 18,827,035 |
Sample size calculations for 3-level cluster randomized trials. | The first applications of cluster randomized trials with three instead of two levels are beginning to appear in health research, for instance, in trials where different strategies to implement best-practice guidelines are compared. In such trials, the strategy is implemented in health care units ('clusters') and aims a... | 18,827,041 |
Toll-like receptors: another player in the pathogenesis of the anti-phospholipid syndrome. | The anti-phospholipid syndrome (APS) is a systemic autoimmune disease characterized by an adaptive immune response against self phospholipid (PL)--binding proteins. Although APS is considered as an autoantibody-mediated disease, there is now evidence that anti-phospholipid antibodies (aPL) are necessary but not suffici... | 18,827,059 |
Differential selective constraints shaping codon usage pattern of housekeeping and tissue-specific homologous genes of rice and arabidopsis. | Intra-genomic variation between housekeeping and tissue-specific genes has always been a study of interest in higher eukaryotes. To-date, however, no such investigation has been done in plants. Availability of whole genome expression data for both rice and Arabidopsis has made it possible to examine the evolutionary fo... | 18,827,062 |
Paternity testing requested by private parties in Italy: some ethical considerations. | In Italy, judicial and extrajudicial requests for paternity testing have increased in recent years. A retrospective analysis of such private extrajudicial requests received by the legal medicine unit of the Department of Environmental Medicine and Public Health of Padua University was conducted to identify problem area... | 18,827,105 |
Cesarean delivery for the second twin. | To examine maternal and infant outcomes after a vaginal delivery of twin A and a cesarean delivery of twin B, and to identify whether the second twin experienced increased short-term morbidity as part of a combined route of delivery. Between January 1, 1999, and December 31, 2000, a prospective cohort study of all cesa... | 18,827,115 |
Treatment of acne using a 3-milligram drospirenone/20-microgram ethinyl estradiol oral contraceptive administered in a 24/4 regimen: a randomized controlled trial. | To assess the efficacy of the combined oral contraceptive containing 3-mg drospirenone/20-microgram ethinyl estradiol (3-mg drospirenone/20-microgram ethinyl estradiol) administered as 24 consecutive days of active treatment after a 4-day hormone-free interval (24/4 regimen) compared with placebo for the treatment of m... | 18,827,119 |
Postpartum screening for diabetes after a gestational diabetes mellitus-affected pregnancy. | To estimate trends in postpartum glucose testing in a cohort of women with gestational diabetes mellitus (GDM). A validated computerized algorithm using Kaiser Permanente Northwest automated data systems identified 36,251 live births or stillbirths from 1999 through 2006. The annual percentage of pregnancies complicate... | 18,827,130 |
Nicotine gum for pregnant smokers: a randomized controlled trial. | To estimate the safety and efficacy of treatment with 2-mg nicotine gum for smoking cessation during pregnancy. Pregnant women who smoked daily received individualized behavioral counseling and random assignment to a 6-week treatment with 2-mg nicotine gum or placebo followed by a 6-week taper period. Women who did not... | 18,827,129 |
Low rates of both asymptomatic chlamydia screening and diagnostic testing of women in US outpatient clinics. | To estimate demographic characteristics of nonpregnant women who seek health care in hospital outpatient clinics, and the proportion of visits where a chlamydia test was not done in asymptomatic young women at preventive visits and in symptomatic women. We analyzed data from the 2005 National Hospital Ambulatory Medica... | 18,827,133 |
Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. | There is poor agreement on definitions of different phenotypes of preschool wheezing disorders. The present Task Force proposes to use the terms episodic (viral) wheeze to describe children who wheeze intermittently and are well between episodes, and multiple-trigger wheeze for children who wheeze both during and outsi... | 18,827,155 |
Time from diagnosis to treatment initiation predicts survival in younger, but not older, acute myeloid leukemia patients. | Acute myeloid leukemia (AML) is considered an oncologic emergency. Delaying induction chemotherapy until molecular testing results return, may benefit some patients but harm others. We examined the effect of time from AML diagnosis to treatment (TDT) on complete remission (CR) and overall survival (OS), using patient c... | 18,827,183 |
Validation of an enzyme-linked immunosorbent assay for diagnosis of human trichinellosis. | Trichinellosis is a zoonotic disease caused by the consumption of raw or semiraw meat from different animals harboring Trichinella larvae in their muscles. Since there are no pathognomonic signs, diagnosis can be difficult; for this reason, serology is important. The objective of this study was to validate an enzyme-li... | 18,827,188 |
Effects of a reduced dose schedule and intramuscular administration of anthrax vaccine adsorbed on immunogenicity and safety at 7 months: a randomized trial. | In 1999, the US Congress directed the Centers for Disease Control and Prevention to conduct a pivotal safety and efficacy study of anthrax vaccine adsorbed (AVA). To determine the effects on serological responses and injection site adverse events (AEs) resulting from changing the route of administration of AVA from sub... | 18,827,210 |
Effectiveness of long-term psychodynamic psychotherapy: a meta-analysis. | The place of long-term psychodynamic psychotherapy (LTPP) within psychiatry is controversial. Convincing outcome research for LTPP has been lacking. To examine the effects of LTPP, especially in complex mental disorders, ie, patients with personality disorders, chronic mental disorders, multiple mental disorders, and c... | 18,827,212 |
Late-life anxiety and cognitive impairment: a review. | Emerging research implicates a consistent reciprocal relationship between late-life anxiety and cognition. Understanding this relationship may clarify pathophysiological substrates of cognitive impairment and why co-occurring anxiety and cognitive impairment relates to poorer treatment prognosis for both conditions. Th... | 18,827,225 |
The surgical anatomy of the blood supply to the femoral head: description of the anastomosis between the medial femoral circumflex and inferior gluteal arteries at the hip. | The inferior gluteal artery is described in standard anatomy textbooks as contributing to the blood supply of the hip through an anastomosis with the medial femoral circumflex artery. The site(s) of the anastomosis has not been described previously. We undertook an injection study to define the anastomotic connections ... | 18,827,238 |
Total knee replacement for patients with ankylosed knees. | The purpose of this study was to determine objectively the outcome of total knee replacement in patients with ankylosed knees. There were 82 patients (99 knees) with ankylosed knees who underwent total knee replacement with a condylar constrained or a posterior stabilised prosthesis. Their mean age was 41.9 years (23 t... | 18,827,240 |
Transphyseal reconstruction of the anterior cruciate ligament in prepubescent children. | We present the results of 17 children of Tanner stage 1 or 2 who underwent reconstruction of the anterior cruciate ligament between 1999 and 2006 using a transphyseal procedure, employing an ipsilateral four-strand hamstring graft. The mean age of the children was 12.1 years (9.5 to 14). The mean follow-up was 44 month... | 18,827,241 |
Prognostic factors and outcome of treatment in Perthes' disease: a prospective study of 368 patients with five-year follow-up. | This nationwide prospective study was designed to determine prognostic factors and evaluate the outcome of different treatments of Perthes' disease. A total of 28 hospitals in Norway were instructed to report all new cases of Perthes' disease over a period of five years and 425 patients were reported and followed for f... | 18,827,249 |
In vivo local administration of osteogenic protein-1 increases structural properties of the overstretched anterior cruciate ligament with partial midsubstance laceration: a biomechanical study in rabbits. | We report the effects of local administration of osteogenic protein-1 on the biomechanical properties of the overstretched anterior cruciate ligament in an animal model. An injury in the anterior cruciate ligament was created in 45 rabbits. They were divided into three equal groups. In group 1, no treatment was applied... | 18,827,254 |
Impact of neurofibromatosis type 1 on school performance. | School functioning of 86 Dutch neurofibromatosis type 1 children (7-17 years) using teacher questionnaires was analyzed to determine the impact of neurofibromatosis type 1 on school performance. In all, 75% of the neurofibromatosis type 1 children performed more than 1 standard deviation below grade peers in at least o... | 18,827,266 |
Clinical observation of self-injurious behavior correlated with changes in scalp morphology in a child with congenital hydrocephalus. | We report the case of a 12-year-old girl born with cerebral dysgenesis and congenital hydrocephalus first shunted shortly after birth. She had severe tissue-damaging self-injurious behavior, profound mental retardation, quadriparesis, as well as multiple cranial anomalies including turricephaly. After stage 1 cranial r... | 18,827,271 |
Epstein-Barr virus-associated meningoencephalomyelitis: intrathecal reactivation of the virus in an immunocompetent child. | Neurologic complications, including meningoencephalitis, transverse myelitis, and peripheral neuropathy, have been reported in patients with acute infectious mononucleosis. Chronic active Epstein-Barr virus and human immunodeficiency virus infections occasionally induce central nervous system lymphoma. On the other han... | 18,827,273 |
Melatonin and its agonists: an update. | The pineal hormone melatonin is able to shift the timing of circadian rhythms, including the sleep-wake cycle, and to promote sleep. Melatonin agonists with similar properties have therapeutic potential for the treatment of circadian rhythm sleep disorders. Depression is specifically targeted by agomelatine, which is a... | 18,827,285 |
Schizophrenia and offspring's risk for adverse pregnancy outcomes and infant death. | Women with schizophrenia are at increased risk for adverse pregnancy outcomes. It is not known whether offspring born to fathers with schizophrenia also have an increased risk. To evaluate paternal and maternal influences on the association between schizophrenia and pregnancy outcomes. A record linkage including 2 mill... | 18,827,293 |
FPGA design and implementation for EIT data acquisition. | OXBACT-5 was designed to meet the challenges involved in working in the intensive care hospital environment focussed particularly on thoracic imaging of patients with respiratory distress and chronic heart failure (CHF). The FPGA-based wireless LAN linked multi-channel EIT data acquisition system (DAS) providing 16 pro... | 18,827,313 |
A model of speckle contrast in optical coherence tomography for characterizing the scattering coefficient of homogenous tissues. | We present a theoretical model for analyzing the speckle contrast of optical coherence tomography (OCT). This model is based on the addition of noise and an OCT signal in the logarithmic scale. The theoretical model reveals that, for the superficial layer of homogenous tissue, the contrast ratio is a linear function of... | 18,827,323 |
Planning lung radiotherapy using 4D CT data and a motion model. | This work is a feasibility study to use a four-dimensional computed tomography (4D CT) dataset generated by a continuous motion model for treatment planning in lung radiotherapy. The model-based 4D CT data were derived from multiple breathing cycles. Four patients were included in this retrospective study. Treatment pl... | 18,827,322 |
Changes in deep abdominal muscle thickness during common trunk-strengthening exercises using ultrasound imaging. | Cross-sectional study design. To characterize changes in muscle thickness in the transversus abdominis (TrA) and internal oblique (IO) muscles during common trunk-strengthening exercises, and to determine whether these changes differ based on age. Although trunk-strengthening exercises have been found to be useful in t... | 18,827,329 |
Development and evaluation of a novel gene delivery vehicle composed of adenovirus serotype 35. | The capacity of gene delivery vehicles is considered to be a critical factor determining the success of gene therapy. To date, various types of gene delivery vehicle have been developed. Among them, recombinant adeno-virus (Ad) vectors have potential that has favored their worldwide use in vitro and in vivo. Convention... | 18,827,334 |
Anti-inflammatory and immunomodulatory properties of 2-amino-3H-phenoxazin-3-one. | Accumulating evidence suggests that nitric oxide (NO) and prostaglandin E(2) (PGE(2)) are involved in the pathogenesis of various chronic inflammatory diseases and cancer. During the course of a screening program to identify natural anti-inflammatory substances, we isolated the compound 2-amino-3H-phenoxazin-3-one (APO... | 18,827,359 |
Development of novel fast-disintegrating tablets by direct compression using sucrose stearic acid ester as a disintegration-accelerating agent. | It was attempted to produce novel furosemide (FS) fast-disintegrating tablets by direct compression. The combination of FS, microcrystalline cellulose, croscarmellose sodium and xylitol was used as the basic formulation, and sucrose stearic acid ester (SSE) was chosen as an additional additive. The tablets with SSE wer... | 18,827,375 |
New organoselenium compounds active against pathogenic bacteria, fungi and viruses. | Different N-substituted benzisoselenazol-3(2H)-ones, analogues of ebselen were designed as new antiviral and antimicrobial agents. We report their synthesis, chemical properties as well as study on biological activity against broad spectrum of pathogenic microorganisms (Staphylococcus aureus, Staphylococcus simulans, E... | 18,827,382 |
Sesquiterpenes from the roots of Cichorium endivia. | Twelve new sesquiterpene and sesquiterpene glycosides were obtained along with eleven known compounds from the roots of Cichorium endivia (Compositae). The compounds were identified as guaianolide, germacrenolide and elemanolide, based on spectroscopic methods and chemical evidence. | 18,827,387 |
Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos. | A new lanostane-type triterpene, 29-hydroxypolyporenic acid C (8), was isolated from the dried sclerotia of Poria cocos together with eight other known compounds pachymic acid (1), dehydropachymic acid (2), 3-acetyloxy-16alpha-hydroxytrametenolic acid (3), polyporenic acid C (4), 3-epi-dehydropachymic acid (5), 3-epi-d... | 18,827,390 |
Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. | The association of the cyclin D-Cdk (DC) complex with retinoblastoma protein (pRb) is required for the G1-S transition of the cell cycle. Cyclin synthesis, nuclear localization and degradation are control mechanisms for the transition, but regulation of the DC complex nuclear import also contributes to the transition. ... | 18,827,403 |
SYP71, a plant-specific Qc-SNARE protein, reveals dual localization to the plasma membrane and the endoplasmic reticulum in Arabidopsis. | SNAREs ('Soluble N-ethyl-maleimide sensitive factor attachment protein receptors') play a critical role in the membrane fusion step of the vesicular transport system in eukaryotes. The number of the genes encoding SNARE proteins is estimated to be 64 in Arabidopsis thaliana. This number is much larger than those in oth... | 18,827,404 |
MicroRNA-206 is highly expressed in newly formed muscle fibers: implications regarding potential for muscle regeneration and maturation in muscular dystrophy. | miR-1, miR-133a, and miR-206 are muscle-specific microRNAs expressed in skeletal muscles and have been shown to contribute to muscle development. To gain insight into the pathophysiological roles of these three microRNAs in dystrophin-deficient muscular dystrophy, their expression in the tibialis anterior (TA) muscles ... | 18,827,405 |
A boy with growth disturbance caused by hypothalamic damage associated with intracranial hypotension syndrome following a motor vehicle accident: case report. | We examined the endocrine profile of a boy aged 10 years and 4 months with intracranial hypotension syndrome (IHS) following a motor vehicle accident. His complaint was growth disturbance. GH secretion gradually decreased and finally was lost in spite of an epidural blood patch procedure. His height velocity was restor... | 18,827,408 |
Hepatocarcinogenesis following HCV RNA eradication by interferon in chronic hepatitis patients. | Interferon (IFN) therapy reduces the incidence of hepatocarcinogenesis in patients with hepatitis C viral (HCV) infection who achieve a sustained virological response (SVR). The aim of the present study was to determine the rate of hepatocarcinogenesis and the risk factor in sustained virological responders. The study ... | 18,827,409 |
The anatomical distribution of colorectal cancer in Korea: evaluation of the incidence of proximal and distal lesions and synchronous adenomas. | The incidence of colorectal cancer throughout the Republic of Korea has been rising over the last 25 years. The change in incidence is supposed to be due to the westernized life style. We evaluated the anatomical distribution of colorectal cancer and the properties of synchronous adenomatous polyps in the Korean popula... | 18,827,411 |
Removal of a foreign body (artificial tooth) from the bronchial tree: a new method. | A 70-year-old man who had aspirated an artificial tooth during treatment at a dental clinic visited our hospital. His symptoms and physical condition were not remarkable. CT of chest revealed a foreign body in the right middle bronchus; bronchoscopy revealed it was wedged there. First, the authors tried to remove it us... | 18,827,418 |
Severe respiratory failure and torsades de pointes induced by disopyramide in a patient with myasthenia gravis. | Class 1a anti-arrhythmic drugs are often used for the treatment of atrial fibrillation (AF), but it is not well known that myasthenia gravis (MG)-like symptoms can be generated by their anti-cholinergic effects. We had a patient with MG who developed symptomatic MG aggravation after AF treatment with disopyramide. Symp... | 18,827,420 |
Strain differences in hepatic cytochrome P450 1A and 3A expression between Sprague-Dawley and Wistar rats. | Expression of hepatic cytochrome P450 (CYP) isoforms was compared in Sprague-Dawley (SD) and Wistar (WI) rats, which are commonly used strains in preclinical studies. Basal CYP1A1, CYP1A2, and CYP3A2 mRNA levels were higher in WI rats than in SD rats (by 8-, 3- and 2-fold, respectively). Treatment with phenobarbital, a... | 18,827,444 |
Expression of sonic hedgehog regulates morphological changes of rat developing cerebellum in hypothyroidism. | Although thyroid hormones are crucial for cerebellar development, and several thyroid hormone-dependent genes are known to be correlated with morphological development of the cerebellum, the precise mechanisms of morphological cerebellar changes in hypothyroidism (HT) remain unknown. To investigate these mechanisms in ... | 18,827,446 |
Chinese dumpling scare hits Japan--a case of methamidophos food poisoning. | An outbreak of food poisoning that affected at least ten people in various regions of Japan was traced to exposure to Chinese dumplings contaminated with the organophosphate insecticide Methamidophos. We experienced the most serious case, a five years old girl, who suffered coma. She presented with features of choliner... | 18,827,448 |
[Inhibitory effects of hybrid liposomes on the growth of gastric tumor cells established from cotton rats]. | We established cell-line (CoRa 622 G6) of gastric carcinoma using cotton rats with spontaneous malignant gastric carcinoma with hypergastrinaemia. Inhibitory effects of hybrid liposomes (HL) composed of dimyristoylphosphatidylcoline (DMPC) and polyoxyethylene (n) dodecyl ether (C(12)(EO)(n): n=21, 23, 25) on the growth... | 18,827,469 |
[NMR analysis of a contaminant in heparin]. | Recently, it has been reported that certain lots of heparin are associated with an acute, rapid onset of serious side effects indicative of allergic reaction, and (1)H NMR is one of the convenience but strong analytical methods to identify a contaminant in heparin. However, an NMR signal from the contaminant in some ca... | 18,827,473 |
Pegylated interferon plus ribavirin combination therapy for chronic hepatitis C in patients with congenital coagulation disorders. | Chronic hepatitis C (CHC) and end-stage liver disease are becoming an increasingly common cause of mortality in patients with congenital bleeding disorders, especially in the HIV-coinfected group. Combination of pegylated interferon (Peg-IFN) and ribavirin has recently become the treatment of choice for CHC. In this st... | 18,827,474 |
Auditory brainstem correlates of basilar membrane nonlinearity in humans. | A behavioral measure of the basilar membrane response can be obtained by comparing the growth in forward masking for maskers at, and well below, the signal frequency. Since the off-frequency masker is assumed to be processed linearly at the signal place, the difference in masking growth with level is thought to reflect... | 18,827,479 |
Role of AIB1 for tamoxifen resistance in estrogen receptor-positive breast cancer cells. | The p160 nuclear receptor coactivator, AIB1 (amplified in breast cancer 1), is frequently overexpressed in human breast cancer and has been shown to be associated with tamoxifen resistance. The present study aimed to investigate the role of AIB1 in tamoxifen resistance of breast cancer cells. We reconstructed the RNA i... | 18,827,493 |
[Comparisons of health inequalities in small areas with using the standardized mortality ratios in Korea]. | This study was performed to compare the standardized mortality ratios among different small areas and to explore the usefulness of standardized mortality ratios in South Korea. To calculate the standardized mortality ratio (SMR), we obtained the national deaths certificate data (2004-2006) and national registration pop... | 18,827,497 |
[Study on the health status of the residents near military airbases in Pyeongtaek City]. | We conducted an epidemiologic survey to evaluate the effect of the aircraft noise exposure on the health of the residents near the military airbases in Pyeongtaek City. The evaluation of environmental noise level, questionnaire survey, and health examination were performed for 917 residents. The study population consis... | 18,827,498 |
Lead hazards for pregnant women and children: part 1: immigrants and the poor shoulder most of the burden of lead exposure in this country. Part 1 of a two-part article details how exposure happens, whom it affects, and the harm it can do. | Poor, urban, and immigrant populations are at far greater risk for lead exposure than are other groups in the United States. Children with even slightly elevated blood lead levels are at increased risk for significant neurobehavioral problems that can extend through adolescence. Research has shown that elevated blood l... | 18,827,541 |
Activity of lipoplatin in tumor and in normal cells in vitro. | Lipoplatin is a novel liposomal cisplatin formulation with reduced adverse side effects compared with its parental compound, cisplatin. The aims of this preclinical study were to compare lipoplatin and cisplatin cytotoxicity in vitro in established cell lines derived from non-small cell lung cancer, renal cell carcinom... | 18,827,563 |
Nonalcoholic fatty liver disease: the potential role of nutritional management. | To review available data pertaining to dietary imbalances and metabolic alterations leading to the development of fatty liver disease and nutritional managements. The importance of treating fatty liver disease is now firmly recognized not only because of the risk of progression toward a more aggressive liver disease bu... | 18,827,582 |
Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma. | Heat shock protein 90 (Hsp90) is an abundant molecular chaperone that mediates the maturation and stability of a variety of proteins associated with the promotion of cell growth and survival. Inhibition of Hsp90 function leads to proteasomal degradation of its mis-folded client proteins. Recently, Hsp90 has emerged as ... | 18,827,603 |
Community-acquired methicillin-resistant staphylococcus aureus: diagnosis and treatment update for plastic surgeons. | : After studying this article, the participant should be able to: 1. Identify risk factors associated with community-acquired methicillin-resistant Staphylococcus aureus. 2. Recognize the clinical presentation of patients with community-acquired methicillin-resistant S. aureus. 3. Understand the treatment and indicatio... | 18,827,629 |
Radiation effects and radioprotection in MC3T3-E1 mouse calvarial osteoblastic cells. | Little is known about the mechanisms and treatment of radiation-induced inhibition of craniofacial bone growth. In an earlier study, the radioprotector amifostine (WR-2721) administered to rabbits before irradiation radioprotected cultured orbitozygomatic complex periosteal osteoblast-like cells. This study assessed th... | 18,827,633 |
Role of TGF-beta and FGF in the treatment of radiation-impaired wounds using a novel drug delivery system. | Despite refinements in radiotherapy, radiation-impaired wound healing continues to be a major source of postoperative morbidity with few treatment options. The application of polypeptide growth factors has been investigated in both the clinical and laboratory settings. The authors used a novel sustained-release deliver... | 18,827,634 |
Scars: a review of emerging and currently available therapies. | With the investigation and potential introduction of several novel scar-reducing therapies to the market within the next several years, it is germane to review both the pathophysiology of scarring and the safety and efficacy of currently available and emerging therapeutic agents. An extensive review of the English-lang... | 18,827,639 |
Spinal cord injury without radiological abnormality in an infant with delayed presentation of symptoms after a minor injury. | We present a very rare case of an infant with delayed presentation of spinal cord injury without radiologic abnormality (SCIWORA) after a minor injury. To emphasize the importance of spinal evaluation with MRI in selected cases, even after minor injuries, especially in infants. SCIWORA arises mainly in infants and chil... | 18,827,684 |
Lumbar epidural capillary hemangioma presenting as lumbar disc herniation disease: case report. | A case of lumbar spinal epidural hemangioma is presented. To present the first reported lumbar spinal epidural hemangioma patient clinically mimicking the lumbar disc herniation disease. Capillary hemangiomas are benign endothelial cell neoplasms that are believed to be hamartomatous proliferations of vascular endothel... | 18,827,685 |
The use of traction in the treatment of severe spinal deformity. | Multicenter, retrospective, nonrandomized comparison group study of patients with severe scoliosis and kyphosis treated after 1995 with halo-gravity traction and without halo-gravity traction before definitive fusion. Compare surgical correction of severe spine deformity with preoperative halo traction and without preo... | 18,827,696 |
Rheumatic disease and complementary-alternative treatments: a qualitative study of patient's experiences. | Complementary-alternative medicine (CAM) has been widely used by rheumatic patients for many years, but doctors are often unaware of the actual use. This study aimed at patients' experience and perceptions of CAM as a way for long-term coping with illness. Fifteen in-depth interviews were conducted with patients sample... | 18,827,715 |
Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model. | Hemoglobin vesicles (HbVs) are artificial oxygen (O2) carriers that encapsulate concentrated hemoglobin (Hb) solution in phospholipid vesicles (liposomes). Recent reports on cytoprotective effects of exogenous carbon monoxide (CO) urged us to test infusion of CO-bound HbV (CO-HbV) and red blood cells (CO-RBC) in hemorr... | 18,827,742 |
Metabolic syndrome and schizophrenia from integrative medicine perspective. | There has been a growing interest in the effect that comorbid schizophrenia and metabolic syndrome may have on each other. To examine metabolic syndrome from integrative medicine point of view including prevalence of metabolic syndrome in patients with schiziphrenia compared to their first-degree relatives, healthy vol... | 18,827,767 |
Association of cholesterol and socio-demographic parameters with suicidality in the male patients with schizophrenia. | Suicidal behavior is a major health risk in schizophrenia. The aim of this study was to evaluate serum cholesterol concentrations and some socio-demographic parameters in suicidal and non-suicidal men suffering from schizophrenia. Results of this study show that there were no differences in socio-demographic parameters... | 18,827,768 |
Pharamacogenetics and antidepressant treatment in integrative psychiatry perspective. | The concept of individualized drug therapy on the basis of pharmacogenetics has become a central focus in the treatment of depression. There is an increasing agreement about the importance of polymorphisms in cytochrome P450 enzymes and the effects of drug-drug interactions in relation to the incidence of adverse effec... | 18,827,770 |
Metabolic syndrome and depression in war veterans with post-traumatic stress disorder. | Post-traumatic stress disorder (PTSD), depression and metabolic syndromes are growing public health problems in post-war countries. Understanding the co-morbidity among PTSD, depression and metabolic syndrome has an important clinical and theoretical issue. To examine the relationship between combat-related PTSD, co-mo... | 18,827,772 |
The role and importance of consulting psychiatry in paediatric surgery. | The main aim of this study was to point on role and importance of consulting psychiatry in paediatric population of patients particularly in branch of paediatric surgery. This study is a view to a few years research on biopsychosocial aspect of treatment of long bones fractures in children and adolescents realized in D... | 18,827,776 |
What is imatinib-resistant chronic myeloid leukemia? Identifying and managing loss of response. | Imatinib is widely recognized as the standard of care in the first-line treatment of chronic myeloid leukemia (CML); however, resistance can limit its long-term benefits. Early identification of the loss of response to imatinib is therefore important for the optimal management of patients with this type of leukemia. Cy... | 18,827,790 |
Preservation of the kidney by carbon monoxide: a black swan phenomenon. | Nakao and colleagues demonstrate that carbon monoxide added to organ preservation solution reduces donor-kidney injury that occurs after cold storage and transplantation and improves the survival of the recipient. These findings are important because they highlight the role of the cytochrome P450 system in the pathogen... | 18,827,798 |
The impact of sodium chloride and volume depletion in the chronic kidney disease of congenital chloride diarrhea. | Congenital chloride diarrhea is due to mutations in the intestinal Cl(-)/HCO(3)(-) exchange (SLC26A3) which results in sodium chloride and fluid depletion leading to hypochloremic and hypokalemic metabolic alkalosis. Although treatment with sodium and potassium chloride offers protection from renal involvement in child... | 18,827,800 |
Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis. | Gene expression profiling is a valuable tool for identifying differentially expressed genes in studies of disease subtype and patient outcome for various cancers. However, it remains difficult to assign biological significance to the vast number of genes. There is an increasing awareness of gene expression profile as a... | 18,827,816 |
Sirtuins--novel therapeutic targets to treat age-associated diseases. | Sirtuins post-translationally modulate the function of many cellular proteins that undergo reversible acetylation-deacetylation cycles, affecting physiological responses that have implications for treating diseases of ageing. Potent small-molecule modulators of sirtuins have shown efficacy in preclinical models of meta... | 18,827,827 |
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. | Histone deacetylases (HDACs)--enzymes that affect the acetylation status of histones and other important cellular proteins--have been recognized as potentially useful therapeutic targets for a broad range of human disorders. Pharmacological manipulations using small-molecule HDAC inhibitors--which may restore transcrip... | 18,827,828 |
Genetic structure of Oryza rufipogon Griff. in China. | Oryza rufipogon Griff. (common wild rice; CWR) is the ancestor of Asian cultivated rice (Oryza sativa L.). Investigation of the genetic structure and diversity of CWR in China will provide information about the origin of cultivated rice and the grain quality and yield. In this study, we used 36 simple sequence repeat (... | 18,827,837 |
Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication. | Analyses of viral protein-protein interactions are an important step to understand viral protein functions and their underlying molecular mechanisms. In this study, we adopted a mammalian two-hybrid system to screen the genome-wide intraviral protein-protein interactions of SARS coronavirus (SARS-CoV) and therefrom rev... | 18,827,877 |
Treprostinil for pulmonary hypertension. | Treprostinil is a stable, long-acting prostacyclin analogue which can be administered as a continuous subcutaneous infusion using a portable miniature delivery system. Subcutaneous treprostinil has been shown in a large multicenter randomized controlled trial to improve exercise capacity, clinical state, functional cla... | 18,827,901 |
Cardiovascular co-morbidity in rheumatic diseases. | Patients with rheumatic disorders have an increased risk of cardiovascular disease (CVD). This excess co-morbidity is not fully explained by traditional risk factors. Disease severity is a major risk factor for CVD in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Shared disease mechani... | 18,827,910 |
The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration. | An ulcer categorized as Fontaine's stage IV represents a chronic wound, risk factor of arteriosclerosis, and co-morbidities which disturb wound healing. Our objective was to analyze wound healing and to assess potential factors affecting the healing process. 199 patients were included in this 5-year study. The signific... | 18,827,918 |
Digital vasculitis: a late complication of anti-tumour necrosis factor alpha therapy. | Anti-tumour necrosis factor alpha therapy has led to significant advancement in the treatment of rheumatological disease. Rarely, anti-TNFalpha antagonists have been associated with vasculitis, predominantly cutaneous leukocytoclastic vasculitis. We present the first case of angiographically-confirmed digital vasculiti... | 18,827,960 |
Flip-the-tip: automated patch clamping based on glass electrodes. | A conventional borosilicate glass patch pipette is glued into a plastic jacket, forming the entity of a FlipTip. One or two three-channel modules of recording tip sockets are mounted on a liquid handler platform to take up FlipTips. The tip sockets are connected to preamplifiers (HEKA) and to a suction system. The inne... | 18,827,988 |
Mechanosensitive ion channels investigated simultaneously by scanning probe microscopy and patch clamp. | Mechanosensitive ion channels play an important role for the perception of mechanical signals such as touch, balance, or sound. Here, a new experimental strategy is presented providing well-defined access to single mechanosensitive ion channels in living cells. As a representative example, the investigation of mechanos... | 18,827,992 |
Estimation of quantal parameters with multiple-probability fluctuation analysis. | The functional properties of central synapses are difficult to study because they can be modulated either presynaptically or postsynaptically, each connection has multiple contacts and release at each contact is stochastic. Moreover, studying central synapses with electrophysiology is complicated by the fact that synap... | 18,828,002 |
Mercury speciation and total trace element determination of low-biomass biological samples. | Current approaches to mercury speciation and total trace element analysis require separate extraction/digestions of the sample. Ecologically important aquatic organisms--notably primary consumers such as zooplankton, polychaetes and amphipods--usually yield very low biomass for analysis, even with significant compositi... | 18,828,006 |
Thyroid uptake of 67Ga-citrate is associated with thyroid autoimmunity and hypothyroidism in patients with sarcoidosis. | To evaluate the association of gallium-67 ((67)Ga)-citrate thyroid uptake with the presence of thyroid disorders in patients with sarcoidosis (S patients). Eighty-four S patients were evaluated by a complete thyroid work-up (neck ultrasound, circulating thyroid hormones and anti-thyroid antibodies, fine-needle aspirati... | 18,828,014 |
Phase II trial of S-1 and concurrent radiotherapy in patients with locally advanced pancreatic cancer. | S-1 has a favorable effect in unresectable pancreatic cancer and a potential radiosensitizer. In addition, daily oral administration of S-1 is more convenient than continuous infusion of 5-fluorouracil. This study was designed to evaluate the efficacy and safety of S-1 and concurrent radiotherapy in patients with local... | 18,828,020 |
Infantile hypertrophic pyloric stenosis: a comparative study of incidence and other epidemiological characteristics in seven European regions. | The objective of this study was to present epidemiologic data on infantile hypertrophic pyloric stenosis (IHPS) from seven well-defined European regions, and to compare incidence and changes in incidence over time between these regions. This was a population-based study using data from registries of congenital malforma... | 18,828,050 |
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