title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Molecular cloning, phylogenetic analysis and expression of a MAPEG superfamily gene from the pufferfish Takifugu obscurus. | The microsomal glutathione S-transferases (MGSTs) of membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) superfamily play an important role in xenobiotics detoxification. Compared to mammals, there is limited information on MAPEGS from fish. We cloned a full length of cDNA sequence of a MGST g... | 18,832,047 |
Morphometrics applied to medical entomology. | Morphometrics underwent a revolution more than one decade ago. In the modern morphometrics, the estimate of size is now contained in a single variable reflecting variation in many directions, as many as there are landmarks under study, and shape is defined as their relative positions after correcting for size, position... | 18,832,048 |
Life history of a basal bird: morphometrics of the Early Cretaceous Confuciusornis. | Confuciusornis sanctus stands out among the remarkable diversity of Mesozoic birds recently unearthed from China. Not only is this primitive beaked pygostylian (birds with abbreviated caudal vertebrae fused into a pygostyle) much more abundant than other avian taxa of this age but differences in plumage between specime... | 18,832,054 |
Experimental evolution of a microbial predator's ability to find prey. | Foraging theory seeks to explain how the distribution and abundance of prey influence the evolution of predatory behaviour, including the allocation of effort to searching for prey and handling them after they are found. While experiments have shown that many predators alter their behaviour phenotypically within indivi... | 18,832,061 |
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis. | In budding yeast, exit from the pachytene stage of meiosis requires the mid-meiosis transcription factor Ndt80, which promotes expression of approximately 200 genes. Ndt80 is required for meiotic function of polo-like kinase (PLK, Cdc5) and cyclin-dependent kinase (CDK), two cell cycle kinases previously implicated in ... | 18,832,066 |
Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion. | We describe here the role of histone deacetylase 3 (HDAC3) in sister chromatid cohesion and the deacetylation of histone H3 Lys 4 (H3K4) at the centromere. HDAC3 knockdown induced spindle assembly checkpoint activation and sister chromatid dissociation. The depletion of Polo-like kinase 1 (Plk1) or Aurora B restored co... | 18,832,068 |
Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. | Genesis of the trophectoderm and inner cell mass (ICM) lineages occurs in two stages. It is initiated via asymmetric divisions of eight- and 16-cell blastomeres that allocate cells to inner and outer positions, each with different developmental fates. Outside cells become committed to the trophectoderm at the blastocys... | 18,832,072 |
Modular control analysis of effects of chronic hypoxia on mouse heart. | Modular control analysis (MoCA; Diolez P, Deschodt-Arsac V, Raffard G, Simon C, Santos PD, Thiaudiere E, Arsac L, Franconi JM. Am J Physiol Regul Integr Comp Physiol 293: R13-R19, 2007) was applied here on perfused hearts to describe the modifications of the regulation of heart energetics induced in mice exposed to 3-w... | 18,832,083 |
Comparative study of selective chromogenic (chromID VRE) and bile esculin agars for isolation and identification of vanB-containing vancomycin-resistant enterococci from feces and rectal swabs. | The new chromogenic agar chromID VRE (cIDVRE; bioMérieux) was compared with bile esculin agar (BD) containing 6 mg/liter vancomycin for the detection of colonization with vanB-containing vancomycin-resistant enterococci (VRE). At 48 h of incubation, the results obtained with both media were comparable. However, cIDVRE ... | 18,832,121 |
Genetic relatedness of Clostridium difficile isolates from various origins determined by triple-locus sequence analysis based on toxin regulatory genes tcdC, tcdR, and cdtR. | A triple-locus nucleotide sequence analysis based on toxin regulatory genes tcdC, tcdR and cdtR was initiated to assess the sequence variability of these genes among Clostridium difficile isolates and to study the genetic relatedness between isolates. A preliminary investigation of the variability of the tcdC gene was ... | 18,832,125 |
A minimalist network model for coarse-grained normal mode analysis and its application to biomolecular x-ray crystallography. | In this article, we report a method for coarse-grained normal mode analysis called the minimalist network model. The main features of the method are that it can deliver accurate low-frequency modes on structures without undergoing initial energy minimization and that it also retains the details of molecular interaction... | 18,832,168 |
Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon. | To examine the role of Rb1 in gastrointestinal (GI) tumors, we generated mice with an Apc(1638N) allele, Rb(tm2brn) floxed alleles, and a villin-cre transgene (RBVCA). These animals had exon 19 deleted from Rb1 throughout the GI tract. We have shown previously that Rb1 deficiency is insufficient for GI tumor initiation... | 18,832,169 |
Hippocampal-dependent learning requires a functional circadian system. | Decades of studies have shown that eliminating circadian rhythms of mammals does not compromise their health or longevity in the laboratory in any obvious way. These observations have raised questions about the functional significance of the mammalian circadian system, but have been difficult to address for lack of an ... | 18,832,172 |
Biomechanical ordering of dense cell populations. | The structure of bacterial populations is governed by the interplay of many physical and biological factors, ranging from properties of surrounding aqueous media and substrates to cell-cell communication and gene expression in individual cells. The biomechanical interactions arising from the growth and division of indi... | 18,832,176 |
Filling the concept with data: integrating data from different in vitro and in silico assays on skin sensitizers to explore the battery approach for animal-free skin sensitization testing. | Tests for skin sensitization are required prior to the market launch of new cosmetic ingredients. Significant efforts are made to replace the current animal tests. It is widely recognized that this cannot be accomplished with a single in vitro test, but that rather the integration of results from different in vitro and... | 18,832,184 |
Effect of minor milk proteins in chymosin separated whey and casein fractions on cheese yield as determined by proteomics and multivariate data analysis. | The objective of this work was to find regressions between minor milk proteins or protein fragments in the casein or sweet whey fraction and cheese yield because the effect of major milk proteins was evaluated in a previous study. Proteomic methods involving 2-dimensional gel electrophoresis and mass spectrometry in co... | 18,832,200 |
Cleanliness scores as indicator of Klebsiella exposure in dairy cows. | This study was designed to explore the relationship between cow and udder cleanliness scores and the risk of isolation of Klebsiella spp. from lower hind legs and teat ends, respectively. The distribution of Klebsiella species was compared among isolates from teat ends, legs, and cases of clinical mastitis obtained fro... | 18,832,213 |
Short communication: malic acid does not promote vaccenic acid accumulation in mixed ruminal fluid with fractionated fish oil by a rumen-simulation technique. | The objective of this study was to determine whether malic acid could promote the accumulation of vaccenic acid in the rumen. The control diet was composed of a 65:35 ratio of forage to concentrate with 1% (dry matter basis) added fractionated fish oil (rich in docosahexaenoic acid), and treatment diets consisted of th... | 18,832,223 |
Genetic relationship between culling, milk production, fertility, and health traits in Norwegian red cows. | First-lactation records on 836,452 daughters of 3,064 Norwegian Red sires were used to examine associations between culling in first lactation and 305-d protein yield, susceptibility to clinical mastitis, lactation mean somatic cell score (SCS), nonreturn rate within 56 d in heifers and primiparous cows, and interval f... | 18,832,226 |
Genetic correlation patterns between somatic cell score and protein yield in the Italian Holstein-Friesian population. | Genetic parameters for somatic cell score (SCS) in the Italian Holstein-Friesian population were estimated addressing the pattern of genetic correlation with protein yield in different parities (first, second, and third) and on different days in milk within each parity. Three approaches for parameter estimation were ap... | 18,832,227 |
Psychosocial factors related to diet among women with recent gestational diabetes: opportunities for intervention. | This study investigated postpartum dietary behaviors among women with recent gestational diabetes mellitus (GDM), the cognitive and social factors related to these, and preferred types of lifestyle support, in order improve the development of diabetes prevention strategies for this group. Participants were a random sam... | 18,832,285 |
Effect of carbon source availability and growth phase on expression of Corynebacterium glutamicum genes involved in the tricarboxylic acid cycle and glyoxylate bypass. | The effect of different carbon sources on the expression of tricarboxylic acid (TCA) cycle genes, along with glyoxylate bypass genes, in Corynebacterium glutamicum was determined. All TCA cycle genes were coordinately expressed in medium containing acetate. Growth in the presence of acetate gave rise to abundant expres... | 18,832,313 |
Aromatic degradative pathways in Acinetobacter baylyi underlie carbon catabolite repression. | Carbon catabolite repression is an important mechanism allowing efficient carbon source utilization. In the soil bacterium Acinetobacter baylyi, this mechanism has been shown to apply to the aromatic degradative pathways for the substrates protocatechuate, p-hydroxybenzoate and vanillate. In this investigation, transcr... | 18,832,315 |
Detection of small RNAs in Pseudomonas aeruginosa by RNomics and structure-based bioinformatic tools. | Inactivation of the Pseudomonas aeruginosa (PAO1) hfq gene, encoding the Sm-like Hfq protein, resulted in pleiotropic effects that included an attenuated virulence. As regulation by Hfq often involves the action of small regulatory RNAs (sRNAs), we have used a shotgun cloning approach (RNomics) and bioinformatic tools ... | 18,832,323 |
The spindle positioning protein Kar9p interacts with the sumoylation machinery in Saccharomyces cerevisiae. | Accurate positioning of the mitotic spindle is important for the genetic material to be distributed evenly in dividing cells, but little is known about the mechanisms that regulate this process. Here we report that two microtubule-associated proteins important for spindle positioning interact with several proteins in t... | 18,832,349 |
CleanEST: a database of cleansed EST libraries. | The EST division of GenBank, dbEST, is widely used in many applications such as gene discovery and verification of exon-intron structure. However, the use of EST sequences in the dbEST libraries is often hampered by inconsistent terminology used to describe the library sources and by the presence of contaminated sequen... | 18,832,365 |
Modeling genetic inheritance of copy number variations. | Copy number variations (CNVs) are being used as genetic markers or functional candidates in gene-mapping studies. However, unlike single nucleotide polymorphism or microsatellite genotyping techniques, most CNV detection methods are limited to detecting total copy numbers, rather than copy number in each of the two hom... | 18,832,372 |
An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. | In order to understand how secreted signals regulate complex morphogenetic events, it is crucial to identify their cellular targets. By conditional inactivation of Fgfr1 and Fgfr2 and overexpression of the FGF antagonist sprouty 2 in different cell types, we have dissected the role of FGF signaling during heart outflow... | 18,832,392 |
Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. | The cardiac outflow tract (OFT) is a developmentally complex structure derived from multiple lineages and is often defective in human congenital anomalies. Although emerging evidence shows that fibroblast growth factor (FGF) is essential for OFT development, the downstream pathways mediating FGF signaling in cardiac pr... | 18,832,393 |
Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat. | Vagal pulmonary myelinated afferents are normally not activated by capsaicin, a selective agonist of transient receptor potential vanilloid type 1 (TRPV1) receptors. This study was carried out to investigate whether the expression of TRPV1 in these afferents is altered when chronic airway inflammation is induced by ova... | 18,832,423 |
Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus. | The activity of the subthalamic nucleus (STN) is intimately related to movement and is generated, in part, by voltage-dependent Na(+) (Na(v)) channels that drive autonomous firing. In order to determine the principles underlying the initiation and propagation of action potentials in STN neurons, 2-photon laser scanning... | 18,832,425 |
Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function. | Hydrogen sulfide (H(2)S) has been proposed as a novel neuromodulator, which plays critical roles in the central nervous system affecting both neurons and glial cells. However, its relationship with neurodegenerative diseases is unexplored. The present study was undertaken to investigate the effects of H(2)S on cell inj... | 18,832,435 |
Familial non-medullary thyroid carcinoma displays the features of clinical anticipation suggestive of a distinct biological entity. | Non-medullary thyroid carcinoma (NMTC) is mostly sporadic, but familial clustering is described. We aimed to compare the features of patients with sporadic and familial NMTC (FNMTC) patients and to assess whether FNMTC patients with parent-child relationship exhibit the 'anticipation' phenomenon (earlier age at disease... | 18,832,444 |
KRAS mutations: an old oncogene becomes a new predictive biomarker. | This commentary highlights a novel assay for detection of mutations in KRAS, which have recently emerged as a useful negative predictive biomarker. | 18,832,458 |
Keeping up with the next generation: massively parallel sequencing in clinical diagnostics. | The speed, accuracy, efficiency, and cost-effectiveness of DNA sequencing have been improving continuously since the initial derivation of the technique in the mid-1970s. With the advent of massively parallel sequencing technologies, DNA sequencing costs have been dramatically reduced. No longer is it unthinkable to se... | 18,832,462 |
Rapid allelic discrimination by TaqMan PCR for the detection of the Gilbert's syndrome marker UGT1A1*28. | Gilbert's syndrome causes mild, unconjugated hyperbilirubinemia and is present in approximately 10% of the Caucasian population. The basis of the disorder is a 70% reduction in bilirubin glucuronidation catalyzed by the UDP-glucuronosyltransferase 1A1 (UGT1A1), which, in Caucasians, is the result of a homozygous TA ins... | 18,832,463 |
Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion. | Acetylcholine (ACh) is a known modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic ACh receptors (nAChRs). Yet, the subunit composition and specific location of nAChRs involved in DA-mediated locomotion remain to be established in vivo. Mice lacking the beta2 subunit of nACh... | 18,832,468 |
Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes. | Glucuronidation via UDP-glucuronosyltransferase (UGT) is an increasingly important clearance pathway. In this study intrinsic clearance (CL(int)) values for buprenorphine, carvedilol, codeine, diclofenac, gemfibrozil, ketoprofen, midazolam, naloxone, raloxifene, and zidovudine were determined in pooled human liver micr... | 18,832,476 |
Telling interviewers about sexual abuse: predictors of child disclosure at forensic interviews. | This study aims to identify characteristics that predict full disclosure by victims of sexual abuse during a forensic interview. Data came from agency files for 987 cases of sexual abuse between December 2001 and December 2003 from Children's Advocacy Centers (CACs) and comparison communities within four U.S. states. C... | 18,832,489 |
Team negotiation: social, epistemic, economic, and psychological consequences of subgroup conflict. | Large collectives (e.g., organizations, political parties, nations) are seldom unitary players. Rather, they consist of different subgroups that often have conflicting interests. Nonetheless, negotiation research consistently regards negotiating teams, who represent these collectives, as monolithic parties with uniform... | 18,832,517 |
Long-term outcomes of physician peer teaching. | Research conducted in 10 cities assessed long-term pediatric asthma outcomes from a peer teaching intervention for physicians to improve their asthma-related clinical and counseling skills. Hypotheses were better outcomes for patients, symptom reduction, less health care use, and enhanced view of the physician. Peers t... | 18,832,540 |
Short-term outcomes of late preterms: an institutional experience. | This article describes the short-term outcomes of late preterm neonates born between 34 and 36 (6/7) weeks gestational age (GA) in a 4-year period. A total of 1381/ 20554 (6.7%) births were between 34 and 36 weeks of GA and were predominantly Caucasian (87%). In all, 697/1381 (51%) were admitted to nursery whereas 684/... | 18,832,549 |
De novo mRNA synthesis is required for both consolidation and reconsolidation of fear memories in the amygdala. | Memory consolidation is the process by which newly learned information is stabilized into long-term memory (LTM). Considerable evidence indicates that retrieval of a consolidated memory returns it to a labile state that requires it to be restabilized. Consolidation of new fear memories has been shown to require de novo... | 18,832,561 |
Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. | Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Molecular determinants of desmoid recurrence remain obscure. beta-Catenin deregulation has been commonly identified in sporadic desmoids although the incidence of CTNNB1 (the gene encoding beta-catenin) mutati... | 18,832,571 |
CGI-58 is an alpha/beta-hydrolase within lipid transporting lamellar granules of differentiated keratinocytes. | CGI-58 is the causative molecule underlying Dorfman-Chanarin syndrome, a neutral lipid storage disease exhibiting apparent clinical features of ichthyosis. CGI-58, associated with triacylglycerol hydrolysis, has an alpha/beta-hydrolase fold and is also known as the alpha/beta-hydrolase domain-containing protein 5. The ... | 18,832,586 |
A large excess in apparent solar oblateness due to surface magnetism. | The shape of the Sun subtly reflects its rotation and internal flows. The surface rotation rate, approximately 2 kilometers per second at the equator, predicts an oblateness (equator-pole radius difference) of 7.8 milli-arc seconds, or approximately 0.001%. Observations from the Reuven Ramaty High-Energy Solar Spectros... | 18,832,608 |
Temperature-induced hydrophobic-hydrophilic transition observed by water adsorption. | The properties of nanoconfined and interfacial water in the proximity of hydrophobic surfaces play a pivotal role in a variety of important phenomena such as protein folding. Water inside single-walled carbon nanotubes (SWNTs) can provide an ideal system for investigating such nanoconfined interfacial water on hydropho... | 18,832,642 |
Imaging preventable infarction in patients with acute ischemic stroke. | One of the goals of neuroimaging in acute ischemic stroke is to identify those patients whose outcome will be improved by therapeutic intervention. This article will discuss the design, analysis, and interpretation of clinical research studies carried out to establish the accuracy and clinical value of neuroimaging to ... | 18,832,661 |
Cutting edge: Immunity against a "silent" salivary antigen of the Lyme vector Ixodes scapularis impairs its ability to feed. | Ixodes scapularis ticks transmit the Lyme disease agent in the United States. Although strong antitick immunity mediates tick rejection by certain vertebrates, only a few Ags have been molecularly characterized. We show that guinea pig vaccination against a secreted tick salivary immunomodulator, sialostatin L2, can le... | 18,832,673 |
Cutting edge: Contact with secondary lymphoid organs drives postthymic T cell maturation. | T cell development, originally thought to be completed in the thymus, has recently been shown to continue for several weeks in the lymphoid periphery. The forces that drive this peripheral maturation are unclear. The use of mice transgenic for GFP driven by the RAG2 promoter has enabled the ready identification and ana... | 18,832,674 |
CD4 T cell-mediated rejection of cardiac allografts in B cell-deficient mice. | CD4 T cell-dependent mechanisms promoting allograft rejection include expression of inflammatory functions within the graft and the provision of help for donor-reactive CD8 T cell and Ab responses. These studies tested CD4 T cell-mediated rejection of MHC-mismatched cardiac allografts in the absence of both CD8 T and B... | 18,832,680 |
Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice. | Autoantigen presentation to T cells is crucial for the development of autoimmune disease. However, the mechanisms of autoantigen presentation are poorly understood. In this study, we show that splenic phagocytes play an important role in autoantigen presentation in murine lupus. Nucleosomes are major autoantigens in sy... | 18,832,681 |
Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. | Immune sensitization and memory generation are required for the development of allergic inflammation. Our previous studies demonstrate that the cyclooxygenase (COX) metabolic pathway is actively involved in allergic responses and COX inhibition increases allergic airway inflammation in a STAT6-independent fashion. To t... | 18,832,692 |
XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma. | Chemokine-mediated recruitment of regulatory cell subsets to the airway during inflammation and enhancement of their activities are potential strategies for therapeutic development in allergic asthma (AA). In this study, we aim to explore the role of XCL1, a chemokine associated with immune suppression and allergy, on ... | 18,832,695 |
NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection. | Pseudomonas aeruginosa is a major cause of nosocomial respiratory infections. The eradication of P. aeruginosa from the lung involves the orchestrated actions of the pulmonary epithelium and both resident and recruited immune cells. The NKG2D receptor is constitutively expressed on the surface of circulating and tissue... | 18,832,705 |
Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. | Phagocytosis of IgG-opsonized microbes via the Fc gamma receptor (Fc gammaR) requires the precise coordination of a number of signaling molecules, including the low-molecular mass GTPases. Little is known about the Ras-family GTPase Rap1 in this process. We therefore investigated its importance in mediating Fc gammaR-d... | 18,832,707 |
Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2. | Human CMV (HCMV) is a ubiquitous beta-herpesvirus which has developed several mechanisms of escape from the immune system. IFN-gamma-induced signaling relies on the integrity of the JAK/STAT pathway which is regulated by phosphorylation steps and leads to nuclear translocation of tyrosine-phosphorylated STAT1 (STAT1-P-... | 18,832,710 |
Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis. | Experimental allergic encephalomyelitis (EAE) is a T cell-mediated autoimmune disease model of multiple sclerosis. Signal transducer and activator of transcription 4 (Stat4) is a transcription factor activated by IL-12 and IL-23, two cytokines known to play important roles in the pathogenesis of EAE by inducing T cells... | 18,832,727 |
The angiogenic response of the aorta to injury and inflammatory cytokines requires macrophages. | The purpose of this study was to define early events during the angiogenic response of the aortic wall to injury. Rat aortic rings produced neovessels in collagen culture but lost this capacity over time. These quiescent rings responded to vascular endothelial growth factor but not to a mixture of macrophage-stimulator... | 18,832,730 |
Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment. | Autoantibody neuromyelitis optica-IgG (NMO-IgG) recognizing aquaporin-4 (AQP4) is implicated as playing a central role in the physiopathology of NMO. The aim of this in vitro-based study was to characterize functional consequences of interaction between NMO-IgG and cells of the neurovascular unit (astrocytes and brain ... | 18,832,732 |
Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction. | Primary graft dysfunction (PGD) is a major complication following lung transplantation. We reported that anti-type V collagen (col(V)) T cell immunity was strongly associated with PGD. However, the role of preformed anti-col(V) Abs and their potential target in PGD are unknown. Col(V) immune serum, purified IgG or B ce... | 18,832,733 |
Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase. | Obstructive sleep apnea leads to chronic intermittent hypoxia (CIH) and is associated with atherosclerosis. We have previously shown that C57BL/6J mice exposed to CIH and a high-cholesterol diet develop dyslipidemia, atherosclerosis of the aorta, and upregulation of a hepatic enzyme of lipoprotein secretion, stearoyl c... | 18,832,746 |
Enhancement of glucose toxicity by hyperbaric oxygen exposure in diabetic rats. | The side effects of hyperbaric oxygen (HBO) treatment, such as oxidative stress and oxygen toxicity, have long been of interest. However, there are no comprehensive studies evaluating such toxic effects in diabetes mellitus (DM). The purpose of this study was to determine the effects of HBO on glucose homeostasis and h... | 18,832,794 |
Growth inhibitory effect of the ternary complex factor Net on human pancreatic carcinoma cell lines. | Pancreatic carcinoma is one of the most aggressive malignancies and carries the most dismal prognoses of all cancers. A better understanding of the genes involving in tumor development may allow us to tackle this rapidly progressive disease. The Net gene belongs to the ternary complex transcription factor (TCF) family ... | 18,832,796 |
Fluoride concentration in dentin of exfoliated primary teeth as a biomarker for cumulative fluoride exposure. | A biomarker for lifetime fluoride exposure would facilitate population-based research and policy making but currently does not exist. This study examined the suitability of primary tooth dentin as a biomarker by comparing dentin fluoride concentration and fluoride exposures. Ninety-nine children's exfoliated primary te... | 18,832,828 |
Gender-specific weight estimation of fetuses between 2,501 and 3,999 g--new regression formulae. | To develop new gender-specific regression formulae to estimate fetal weight focusing on a particular weight range from 2,501 to 3,999 g. 3,254 singleton pregnancies were included to generate new regression formulae for female and male fetuses, and to evaluate their accuracy. In comparison with commonly used formulae, t... | 18,832,848 |
Single large inguinal lymph node metastasis in human papillomavirus-induced early invasive vulvar cancer of the anterior fourchette in two young women. | The incidence of human papillomavirus (HPV)-induced vulvar cancer in young women is increasing and often presents as microinvasive or early invasive tumors in a grade 3 vulvar intraepithelial neoplasia. So far, the risk of lymph node metastases in early invasive vulvar carcinoma (depth of invasion 1.1-2.0 mm) is report... | 18,832,852 |
Association of A/G polymorphism in intron 13 of the monoamine oxidase B gene with schizophrenia in a Spanish population. | Monoamine oxidase B (MAO-B) enzyme is involved in the oxidative metabolism of dopamine. We studied whether the A644G polymorphism in intron 13 of the MAO-B gene is a risk factor for schizophrenia. 242 subjects diagnosed with schizophrenia and related disorders and 290 hospital-based controls participated in the study. ... | 18,832,861 |
Protection against dryness of facial skin: a rational approach. | Facial skin is unique in that it gets far more exposure to the external environment than skin on other areas of the body and paradoxically, because it contains the thinnest epidermis and stratum corneum, especially on the eye lid. Environmental attacks contribute to drying of facial skin and damage to the stratum corne... | 18,832,866 |
The 3-year renal safety of a tenofovir disoproxil fumarate vs. a thymidine analogue-containing regimen in antiretroviral-naive patients. | Cases of renal dysfunction in patients receiving tenofovir disoproxil fumarate (TDF) have been reported. We analyzed the renal safety of TDF compared with thymidine analogue-containing (control) regimens through 144 weeks from two clinical trials in antiretroviral-naive HIV-infected patients. We evaluated the changes i... | 18,832,879 |
The therapeutic phase I trial of the recombinant native HIV-1 Tat protein. | The native HIV-1 Tat protein was chosen as a vaccine candidate based on its key role in the virus life cycle and on the correlation of Tat-specific immune responses with the asymptomatic stage and lower disease progression rates, but also due to its sequence conservation amongst the various HIV clades as well as the ad... | 18,832,884 |
Antigenic mimicry of the HIV envelope by AIDS-associated pathogens. | Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/l) through a carbohydrate-dependent interaction (50% inhibitory concentration for D-fructose, 12 mmol/... | 18,832,887 |
Correlation of vascular endothelial growth factor with the severity of thalassemia intermedia. | Several lines of evidence indicate that thalassemia intermedia is associated with disturbances in vascular endothelial cell proliferation. In addition, autopsy studies of thalassemia intermedia reported obstructive lesions in the pulmonary artery in 44% of cases, especially splenectomized patients, and a recent in-vivo... | 18,832,899 |
Protein S deposition at placenta: a possible role of protein S other than anticoagulation. | Protein S is an antithrombotic cofactor for protein C that also has multifunctional anti-inflammatory, cellular protective, apoptotic and mitogenic properties. Protein S levels are thought to decrease during pregnancy, but the underlying mechanism remains unknown. We compared protein S concentrations throughout normal ... | 18,832,905 |
New advances in hematopoietic cell transplantation. | The present review highlights sentinel work published since 2006 on the definition of the transplantation barrier and the elucidation of cytokine and immune response gene variation in defining posttransplant risks. Recent work has defined the relative importance of matching for the classical human leukocyte antigen (HL... | 18,832,924 |
Radioactive iodine (131I) effects on male fertility. | Radiometabolic therapy with radioactive iodine (I) is the standard treatment for differentiated thyroid cancer and is also currently the treatment of choice for Graves' disease in the United States. and in most countries. Men younger than 40 years of age represent about 10% of all radiometabolic treatments. Thus, the q... | 18,832,945 |
Follicle-stimulating hormone treatment of male infertility. | Treatment with gonadotrophins is very effective in patients affected by hypogonadotrophic hypogonadism. The success of follicle-stimulating hormone (FSH) treatment in these men has brought the utilization of the same therapy in infertile oligozoospermic patients, aimed at obtaining a quantitative increase in sperm coun... | 18,832,946 |
An open pilot study of the combination of escitalopram and bupropion-SR for outpatients with major depressive disorder. | Monotherapy with a selective serotonin reuptake inhibitor (SSRI) is the most common initial treatment for major depressive disorder (MDD), but this monotherapy leads to remission in fewer than a third of patients. The combination of the SSRI escitalopram and bupropion-SR is commonly used for treating patients with MDD ... | 18,832,958 |
Normal values of hertel exophthalmometry in children, teenagers, and adults from Tehran, Iran. | The aim of this study was to present normative values of exophthalmometry in Iranian children, teenagers, and adults and find the effect of age, gender, height, weight, and laterality (right vs. left eye) on normal values of protrusion. In a population-based epidemiological study, ocular protrusion values (mm) were mea... | 18,832,980 |
Immune response of human propagated gammadelta-T-cells to neuroblastoma recommend the Vdelta1+ subset for gammadelta-T-cell-based immunotherapy. | Human peripheral gammadelta-T-cells are able to induce cytolysis of neuroblastoma (Nb) tumor cells. Besides innate effector functions against infected cells and tumors, gammadelta-T-cells are involved in T-helper 1/T-helper 2 (TH1/TH2) differentiation of alphabeta-T-cells. However, as different gammadelta-T-cell subset... | 18,832,998 |
Clinical-scale lentiviral vector transduction of PBL for TCR gene therapy and potential for expression in less-differentiated cells. | In human gene therapy applications, lentiviral vectors may have advantages over gamma-retroviral vectors because of their ability to transduce nondividing cells, their resistance to gene silencing, and a lack of integration site preference. In this study, we used VSV-G pseudotype third generation lentiviral vectors har... | 18,833,004 |
Proposed guidelines for use of dermal and subdermal fillers. | The great variety of injectable substances for esthetic treatments and their many adverse effects evidence the necessity for agreement among the experts who use such substances. The guidelines to be followed should take into consideration the ideal features of a filler, the criteria of choice (anatomic area, type of im... | 18,833,061 |
Dendritic cell vaccines in metastasized malignant melanoma. | Dendritic cells as immunotherapeutic agents against malignancies have been applied for over ten years. Proof of principle studies demonstrated immunogenicity of dendritic cells even in patients suffering from advanced malignancies. Clinicians and immunologists early focused on this innovative immunotherapeutic approach... | 18,833,080 |
[Brain evoked potentials as correlates of neural dysfunction in the myofascial pain syndrome]. | To study the peculiarities of nervous system functioning in the conditions of nociceptive afferentation from myofascial trigger points in the myofascial pain syndrome (MFPS), 130 patients, 57 men and 73 women, aged from 20 to 55 years, have been examined. A method of somatosensory evoked potentials (SSEP) with recordin... | 18,833,107 |
[Cognitive evoked potentials in panic disorders]. | Sixteen healthy people and 79 patients with panic disorders (PD), including 50 patients with neurosis (ICD-10 F40-41), 18 with personality disorder (F60) and 11 with schizotypal disorder (F21) have been studied. The main investigation method is recording of cognitive evoked potentials (P300 parameters). Mental and neur... | 18,833,108 |
[Changes of the level of serum antibodies to neuroantigens in patients with schizophrenia during the treatment]. | The level of antibodies (AT) to neuroantigens (nerve growth factor and basic myelin protein) has been studied in the serum of 80 patients with schizophrenia, attack-like type, (ICD-10 items F20.01-02) during the treatment with psychotropic drugs. Therapeutic effectiveness has been measured clinically and with the PANSS... | 18,833,110 |
[How to raise efficacy of myringoplasty in extensive defects]. | A comparative trial of miringoplasty efficacy with or without application of biosynthetic wound cover Biocom-1 was performed in 82 patients with sub- and total chronic defects or acute traumatic rupture of the tympanic membrane (58 and 24 patients, respectively). Better clinico-morphological and functional results were... | 18,833,123 |
[Histamine releasing and immunomodulating activity of dental restorative materials]. | Histamine releasing and immunomodulating activity of the following dental restorative materials (DRM) - Prizmafil, Filtek Z250, XRV Herculite Prodigy, Glasiosite, Te-Econol, Valux Plus, Polofil Supra were studied. It was shown that DRM under study as a rule did not possess the ability to release histamine (H) from huma... | 18,833,129 |
[Experimental study of the effectiveness of indirect electrochemical blood oxidation and antioxidant therapy in the treatment of infectious soft tissue wounds]. | In experiments on rats in the process of soft tissues festering wounds treatment there was substantiated the inclusion of 0.03% sodium hypochlorite and antioxidant <<Recsod>> into basic therapy schedule. These preparations inclusion let reduce antioxidant stress and endogenous intoxication levels and elimin... | 18,833,131 |
[State of local immunity in patients with chronic generalized parodontitis]. | The aim of this work was the determination of the state of local immunity in periodontal complex in patients with chronic generalized periodontitis (CGP). 96 individuals were examined (mean age 43.6+/-1.2 years). All the patients were divided into 2 groups: basic group with CGP patients (76 persons) and comparative gro... | 18,833,135 |
[The function of gastric stump and duodenum after proximal gastric resection in patients with esophageal and gastric varicose veins dilatation]. | The authors had developed the technique of proximal gastric resection with cardiac orifice plasty. 21 patients with esophageal and varicose veins dilatation were operated on using the technique. Follow-up period came from 2 to 23 years. Results of the operation allow proximal gastric resection with cardiac orifice plas... | 18,833,147 |
[Clinical aspects of diagnostics and surgical treatment of acute primary purulent destructive pyelonephritis]. | 79 patients with the acute primary non-obstructive pyelonephritis were treated during 2003-2006. 24 (30.3%) patients were operated on with the diagnosis of acute primary purulent destructive pyelonephritis. Organopreserving operations were performed in 23 (95.8%) of patients. The early diagnostics of purulent destructi... | 18,833,158 |
[The use of axamon in the complex rehabilitation of patients with movement disorders in the pathology of lumbar spine]. | The authors review the use of axamon in the complex rehabilitation of neurological patients with movement disorders in the pathology of lumbar spine. Axamon (ipidacrine) stimulates neuromuscular transmission and excitement conduction via nerves and smooth muscles due to the blockade of potassium channels of the excited... | 18,833,171 |
[Surgical tactics of obturative large bowel tumor obstruction]. | Results of Hartmann operation performed on tumor left colon part obturation in general hospitals. Results of 117 patients' treatment were analysed. The local tumor recurrence was registered in 17 (14,5%) cases, mean time between initial and reconstructive operations was 7,2 months. Results of 61 patients for whom the t... | 18,833,178 |
[Surgical treatment of haemorrhoids]. | The new improved modification of haemorrhoidectomy was warked out. The mucosa is dissected 0,5-0,7 sm above the node basis, it is separated sharply from the mucosa, whereupon the vascular pedicle is ligated. After cutting the haemorrhoid node off, a continuous submucosal suture is used to submerge the stump in the subm... | 18,833,179 |
Zili is required for germ cell differentiation and meiosis in zebrafish. | Small RNAs exert an effect through diverse RNA interference pathways to transcriptionally or post-transcriptionally silence their targets. The Piwi-interacting RNAs (piRNAs) represent a germline-specific small RNA pathway where Piwi proteins themselves are thought to mediate piRNA biosynthesis. Here, we provide strong ... | 18,833,190 |
A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells. | Oxidative maturation of secretory and membrane proteins in the endoplasmic reticulum (ER) is powered by Ero1 oxidases. To prevent cellular hyperoxidation, Ero1 activity can be regulated by intramolecular disulphide switches. Here, we determine the redox-driven shutdown mechanism of Ero1alpha, the housekeeping Ero1 enzy... | 18,833,192 |
Association of arterial stiffness with the angiotensin-converting enzyme gene polymorphism in healthy individuals. | Arterial stiffness is an important determinant of cardiovascular morbidity and mortality. The I/D polymorphism of angiotensin-converting enzyme (ACE) gene is associated with cardiovascular disease. However, the relationship between ACE polymorphism, arterial stiffness, and wave reflections in healthy, low-risk populati... | 18,833,197 |
Night time blood pressure variability is a strong predictor for cardiovascular events in patients with type 2 diabetes. | We aimed this study to test the hypothesis that short-term blood pressure (BP) variability and abnormal patterns of diurnal BP variation, evaluated by ambulatory BP (ABP), predicts risk of incident cardiovascular disease (CVD) in patients with type 2 diabetes (T2DM). ABP monitoring (ABPM) was performed in 300 patients ... | 18,833,198 |
A convenient, high-throughput method for enzyme-luminescence detection of dopamine released from PC12 cells. | This protocol represents a novel enzyme-luminescence method to detect dopamine sensitively and rapidly with high temporal resolution. In principle, dopamine is first oxidized with tyramine oxidase to produce H(2)O(2), and then the produced H(2)O(2) reacts with luminol to generate chemiluminescence in the presence of ho... | 18,833,200 |
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