title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Remeasuring the double helix. | DNA is thought to behave as a stiff elastic rod with respect to the ubiquitous mechanical deformations inherent to its biology. To test this model at short DNA lengths, we measured the mean and variance of end-to-end length for a series of DNA double helices in solution, using small-angle x-ray scattering interference ... | 18,927,394 |
Influence of Campylobacter fetus subsp. fetus on ram sperm cell quality. | Campylobacter fetus subsp. fetus infection can occur in female sheep, causing infertility or abortion. Despite extensive research on the effect of these bacteria on female fertility, little research has been done on the influence of C. fetus subsp. fetus on the male factor. Our objective was to examine the influence of... | 18,927,420 |
Determinants of awareness, initiation and maintenance of physical activity among the over-fifties: a Delphi study. | To develop effective interventions to stimulate physical activity (PA), insight into its underlying variables is needed. The aim of this study was to obtain an overview of the most relevant determinants of awareness, initiation and maintenance of PA among the over-fifties by means of a three-round Delphi study. In the ... | 18,927,443 |
The political solidarity model of social change: dynamics of self-categorization in intergroup power relations. | Social and political change involves a challenge to the status quo in intergroup power relations. Traditionally, the social psychology of social change has focused on disadvantaged minority groups collectively challenging the decisions, actions, and policies of those in positions of established authority. In contrast, ... | 18,927,471 |
Busulfan produces efficient human cell engraftment in NOD/LtSz-Scid IL2Rgamma(null) mice. | Xenografting immunodeficient mice after low-dose irradiation has been used as a surrogate human hematopoietic stem cell (HSC) assay; however, irradiation requires strict and meticulous animal support and can produce significant mortality rates, limiting the usefulness of this model. In this work, we examined the use of... | 18,927,475 |
How much time does it take to get a pressure ulcer? Integrated evidence from human, animal, and in vitro studies. | Severe pressure ulcers and deep tissue injury are associated with higher mortality rates, longer hospital stays, and costly treatment. Time is a critical factor in commonly employed measures (eg, pressure redistribution for wheelchair users and patient turning schedules) to prevent pressure ulcers and deep tissue injur... | 18,927,481 |
Evaluation of the antioxidant activity of Syzygium cumini leaves. | The antioxidant activity of Syzygium cumini leaf extracts was investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging and ferric-reducing antioxidant power (FRAP) assays. The methanolic extract and its four water, ethyl acetate, chloroform, and n-hexane fractions were prepared and subjected ... | 18,927,517 |
Recent synthetic approaches toward non-anomeric spiroketals in natural products. | Many natural products of biological interest contain [6,5]- and [6,6]-spiroketal moieties that can adopt various configurations, benefiting or not from anomeric conformation stabilizing effects. The spiroketal fragments are often important for the biological activity of the compounds containing them. Most stable spirok... | 18,927,519 |
Inhibitory effect of antihypertensive drugs on calcineurin in cardiomyocytes. | In recent years, a handful of research investigations have shown that some antihypertensive drugs, i.e., angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), and calcium channel blocker (CCB), can inhibit myocardial expression and/or activity of calcineurin. Calcineurin is a Ca(2+)-calmod... | 18,927,543 |
Ethnicity and weight status affect the accuracy of proxy indices of insulin sensitivity. | This study tested the hypotheses that correlations between direct measures of insulin sensitivity and proxy indices of insulin sensitivity derived from fasting values, (i) would not be affected by ethnicity, and (ii) would be stronger in overweight vs. weight-reduced states. We further hypothesized that associations be... | 18,927,554 |
Fluoride varnish reduces white spot lesions during orthodontic treatment. | This was a randomised controlled trial (RCT) set in a community dental practice. The test varnish was a commercially available product, Fluor Protector (Ivoclar Vivadent, Schaan, Liechtenstein), containing 0.1% fluoride as difluorosilane in a polyurethane varnish base. The placebo varnish applied had an identical compo... | 18,927,569 |
Do folic acid supplements reduce facial clefts? | This was a national population-based case-control study in Norway. CASE AND CONTROL SELECTION: Cases consisted of all newborn infants born from 1996-2001 who had been referred for surgical treatment of a cleft [either cleft lip with or without cleft palate (377 children) or cleft palate only (196 children)]. Controls (... | 18,927,570 |
Handsearching still a valuable element of the systematic review. | The Cochrane Methodology Register, Medline, Embase, AMED, Biosis, Cinahl, LISA, and Psycinfo were consulted along with researchers who may have carried out relevant studies. Studies were considered eligible if they compared searching by hand with searching one or more electronic databases to identify reports of randomi... | 18,927,572 |
Epigenome dynamics: a quantitative genetics perspective. | Classically, quantitative geneticists have envisioned DNA sequence variants as the only source of heritable phenotypes. This view should be revised in light of accumulating evidence for widespread epigenetic variation in natural and experimental populations. Here we argue that it is timely to consider novel experimenta... | 18,927,581 |
Comparison of higher order aberrations in eyes with aspherical or spherical intraocular lenses. | To compare ocular, internal, corneal aberrations, and contrast sensitivity in patients implanted with aspheric or spherical intraocular lenses (IOLs). Total, corneal, and internal aberrations were measured using ray-tracing technology in 23 eyes implanted with aspheric (Tecnis ZA9003) IOLs, and in 25 eyes implanted wit... | 18,927,594 |
Signaling flux redistribution at toll-like receptor pathway junctions. | Various receptors on cell surface recognize specific extracellular molecules and trigger signal transduction altering gene expression in the nucleus. Gain or loss-of-function mutations of one molecule have shown to affect alternative signaling pathways with a poorly understood mechanism. In Toll-like receptor (TLR) 4 s... | 18,927,610 |
Shoulder dystocia: what is the risk of recurrence? | To study the recurrence risk of shoulder dystocia in women who have previously experienced at least once shoulder dystocia. A retrospective study of vaginal deliveries complicated by shoulder dystocia. Setting. American University of Beirut Medical Center - Lebanon. Vaginal deliveries complicated by shoulder dystocia o... | 18,927,947 |
[Vascular pathology in first-degree relatives of patients with intracranial aneurysms]. | An aim of the study was to compare by the analysis of pedigrees the frequency of vascular pathology in first-degree relatives (FDR) of patients with intracranial aneurysms (IA) and controls. Pedigrees were selected by interviewing 194 patients with IA (94 men and 100 women) and 193 age- and sex-matched control patients... | 18,927,979 |
Advances in endoscopic sinonasal and anterior skull base surgery. | Endoscopic transnasal surgery is rapidly replacing more radical external 'open' procedures. At Groote Schuur Hospital, Cape Town, we performed 94 advanced endoscopic sinonasal and anterior skull base procedures over a 2-year period. Most of these would previously have been performed using large external incisions requi... | 18,928,042 |
County government resources associated with dependent-adult abuse investigations in Iowa. | This study evaluated on a county level the association of Iowa's domestic dependent-adult abuse investigations with the location of adult protective services (APS) offices, rurality, government resources, felony charges and prosecutions, child abuse reports, and census demographics. In 2003, the rate of dependent-adult... | 18,928,053 |
Control of blood-transmitted infections in dentistry. | As knowledge has accumulated on the blood-transmitted pathogenic agents, the contact with biological fluids (blood, plasma, saliva, etc.) from apparently healthy individuals has started to be regarded as a real professional risk for dentists. Theoretically, exposure to a contaminated biological specimen may have as a c... | 18,928,060 |
Virulence characteristics of Escherichia coli isolates from children with urinary tract infections. | The urinary tract is among the most common sites of bacterial infection and E. coli is by far the most common infecting agent in children and adults of both sexes. In an attempt to evaluate the intrinsic virulence of E. coli uroisolates from children, 54 strains were assessed by using PCR for the presence of five repre... | 18,928,062 |
Fungal control of pathogenic fungi isolated from wild plants in Taif Governorate, Saudia Arabia. | Twenty two plants were collected from Taif Governorate and identified as: Euphorbia glomerifera, Juniperus procera, Launaea mucronata, Capparis dcidua, Punica granatum, Opuntia ficus, Prunus persica, Eucalyptus globulus, Medicago sativa, Artemisia monosperma, Trichodesma calathiforme, Artemisia judaica, Foeniculum vulg... | 18,928,069 |
Histomorphometric characteristics of peritoneal blood microvessels. | We assessed histological characteristics and sex related differences in morphometric parameters of healthy persons' peritoneal blood vessels. Eighteen samples of parietal peritoneum were collected from 11 healthy persons with elective abdominal surgery, 6 males and 5 females, age range 44-58. Tissue samples were prepar... | 18,928,159 |
Renal Doppler ultrasound in patients with hypertension and metabolic syndrom. | Evaluation of the renal changes by conventional and Doppler ultrasound (US) was performed in patients with hypertension and obesity. 67 persons were examined and divided in 3 groups. Group I includes 27 patients--15 M and 12 F, average age 52+/-4.87 with well controlled diabetes mellitus type II and hypertension, Ccr.-... | 18,928,166 |
[Frequency of polyneuropathy signs in CAPD patients]. | It is well known that polyneuropathy has been an important cause of disability in patients maintained on hemodialysis as well as on peritoneal dialysis. The present study was aimed to analyze frequency and causes of polyneuropathy in patients on continuous ambulatory peritoneal dialysis (CAPD). Sixty three CAPD patient... | 18,928,181 |
[Left ventricular hypertrophy in patients on hemodialysis: importance of anemia]. | Cardiovascular diseases are the most frequent cause of mortality in hemodialysis patients. Left ventricular hypertrophy is the main risk factor for development of cardiovascular morbidity and mortality in patients on hemodialysis. Anemia is the only main risk factor for the development of left ventricular hypertrophy i... | 18,928,184 |
Bioinformatics databases and tools in virology research: an overview. | Viruses are major factors of human infectious diseases. Understanding of the structure-function correlation in viruses is important for the identification of potential anti-viral inhibitors and vaccine targets. In virology research, virus-related databases and bioinformatic analysis tools are essential for discerning r... | 18,928,197 |
Vector-G: multi-modular SVM-based heterotrimeric G protein prediction. | Heterotrimeric G proteins interact with G protein-coupled receptors in response to stimulation by hormones, neurotransmitters, chemokines, and sensory signals to intracellular signaling cascades. Recently reported studies indicate that G protein subunits play a significant role in different eukaryotic diseases includin... | 18,928,202 |
Elder abuse: the Canadian experience. | Abuse and neglect of older adults occurs in all Canadian communities and solutions require the coordinated efforts of society at large. Amelioration entails more than a legislative approach. Prevention of this growing problem is a social responsibility that requires networking and collaboration between different discip... | 18,928,213 |
Mitomycin protection of peridural fibrosis in lumbar disc surgery. | In this prospective, randomized clinical study the authors sought to evaluate the effects of locally applied mitomycin C on peridural fibrosis during lumbar microdiscectomy. Patients undergoing lumbar disc surgery were randomly divided into 2 groups. Thirty patients had 1 mg/ml mitomycin C applied at the site of discec... | 18,928,218 |
Unilateral atlantal mass hypertrophy in acromegaly. Case report. | The authors report an extremely rare case of a patient with acromegaly who had unilateral enlargement of an atlas facet resulting in cord compression and progressive quadriparesis. Although unilateral atlas facet enlargement has been identified in the literature in cases of spondylosis and as a component of congenital ... | 18,928,225 |
Magnetic resonance imaging versus histological assessment for estimation of lesion volume after experimental spinal cord injury. Laboratory investigation. | The purpose of this study was to compare measures of lesion volume obtained by means of 1.5-T MR imaging to those obtained by the Cavalieri method, 6 weeks after experimental spinal cord injury. Nine male Wistar rats were subjected to spinal cord injury by clip compression (50 g) at the T-4 level. Six weeks postinjury,... | 18,928,229 |
Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis. | Mycobacterium tuberculosis, the causative agent of tuberculosis, produces unique sulfated metabolites associated with virulence. One such metabolite from M. tuberculosis lipid extracts, S881, has been shown to negatively regulate the virulence of M. tuberculosis in mouse infection studies, and its cell-surface localiza... | 18,928,249 |
Nickel-catalyzed reductive carboxylation of styrenes using CO2. | A nickel-catalyzed reductive carboxylation of styrenes using CO2 has been developed. The reaction proceeds under mild conditions using diethylzinc as the reductant. Preliminary data suggests the mechanism involves two discrete nickel-mediated catalytic cycles, the first involving a catalyzed hydrozincation of the alken... | 18,928,253 |
Extending pummerer reaction chemistry. Application to the total synthesis of (+/-)-dibromoagelaspongin. | The sponge metabolite dibromoagelaspongin was synthesized in 16 steps from imidazole. The route features two successive oxidative cyclizations with complete control of regiochemistry to deliver the unusual triaminomethane core of the target. These oxidative cyclizations likely resulted from Pummerer-like processes on t... | 18,928,282 |
Impact of food disinfection on beneficial biothiol contents in strawberry. | In this study, the impact of four food disinfectants including hydrogen peroxide, free chlorine, and gaseous- and aqueous-phase ozone with industrial doses on the concentration of biothiol compounds gamma-glutamylcysteinylglycine (GSH) and cystein (CYS) in strawberry was investigated for 1, 5, 15, 30, and 60 or 120 min... | 18,928,295 |
Interactions between beta-lactoglobulin and aroma compounds: different binding behaviors as a function of ligand structure. | Interactions between beta-lactoglobulin (BLG) in its monomeric form and a wide range of aroma compounds were investigated by Fourier transform infrared (FT-IR) and 2D nuclear magnetic resonance (NMR) spectroscopies. A screening of the ligands was carried out by FT-IR through the amide I region changes of BLG upon bindi... | 18,928,299 |
Isotope exchange at equilibrium indicates a steady state ordered kinetic mechanism for human sulfotransferase. | Cytosolic sulfotransferase (SULT)-catalyzed sulfation regulates biosignaling molecular biological activities and detoxifies hydroxyl-containing xenobiotics. The universal sulfuryl group donor for SULTcatalyzed sulfation is adenosine 3'-phosphate 5'-phosphosulfate (PAPS). The reaction products are a sulfated product and... | 18,928,301 |
A novel ferroceneylazobenzene self-assembled monolayer on an ITO electrode: photochemical and electrochemical behaviors. | A novel ferroceneylazobenzene self-assembled monolayer (SAM) has been constructed on an indium-tin oxide (ITO) electrode via the covalent attachment of 4-(4'-11-ferrocenyl-undecanoxyphenylazo)benzoic acid ( FcAzCOOH) onto a silanized ITO substrate surface and verified by reflectance infrared spectroscopy and water cont... | 18,928,307 |
Self-arrangement among charge-stabilized gold nanoparticles on a dithiothreitol reactivated octanedithiol monolayer. | Gold surfaces and structures modified with octanedithiol were reacted with dithiothreitol prior to immersion in buffered solutions of charge stabilized gold nanoparticles. The procedure gives a dithiol layer with adequate properties for a homogeneous octanedithiol monolayer and uniform and reproducible gold nanoparticl... | 18,928,323 |
Improving psychostimulant adherence in children with ADHD. | Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder of childhood, characterized by excessive inattention, hyperactivity and impulsivity. Effective medication exists for the condition, yet suboptimal long-term effects persist for children with ADHD. Poor adherence is a common issue for indiv... | 18,928,348 |
Peripheral intracranial aneurysms: management challenges in 60 consecutive cases. | The authors report the management and outcomes of 55 patients with 60 intracranial aneurysms arising distal to the major branch points of the circle of Willis and vertebrobasilar system. Between July 1997 and December 2006, the authors' neurovascular service treated 2021 intracranial aneurysms in 1850 patients. The dat... | 18,928,355 |
NOD-like receptors: role in innate immunity and inflammatory disease. | The NOD-like receptors (NLRs) are a specialized group of intracellular receptors that represent a key component of the host innate immune system. Since the discovery of the first NLR almost 10 years ago, the study of this special class of microbial sensors has burgeoned; consequently, a better understanding of the mech... | 18,928,408 |
Psychotropic medication utilization at a group-home residential facility for children and adolescents. | The purpose of this study was to examine psychotropic medication utilization over the course of treatment for children and adolescents admitted to a large residential group-home facility for youth with emotional and behavioral disorders. Retrospective analyses of psychotropic medication utilization at admission, during... | 18,928,416 |
Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protection. | Reactive oxygen species (ROS) are considered a key factor in brain aging process. Complex I of the mitochondrial respiration chain is an important site of ROS production and hence a potential contributor to brain functional changes with aging. Appropriate antioxidant strategies could be particularly useful to limit thi... | 18,928,424 |
Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn's disease. | Tumour necrosis factor inhibitors have revolutionised the management of Crohn's disease, but reports of a possible association between concomitant infliximab and immunomodulator therapy and hepatosplenic T-cell lymphoma (a rare form of aggressive non-Hodgkin's lymphoma) have emerged. We describe the first case in Austr... | 18,928,444 |
Hyperinsulinism and hyperammonaemia syndrome due to a novel missense mutation in the allosteric domain of the glutamate dehydrogenase 1 gene. | Congenital hyperinsulinism is one of the causes of persistent hypoglycaemia in neonates and infants. We describe a one-month-old boy with a rare form of congenital hyperinsulinism characterised by hypoglycaemia and hyperammonaemia. | 18,928,469 |
Combined magnetic resonance coronary artery imaging, myocardial perfusion and late gadolinium enhancement in patients with suspected coronary artery disease. | Cardiovascular magnetic resonance (CMR) imaging offers methods for the detection of ischemia and myocardial infarction as well as visualization of the coronary arteries (MRCA). However, a direct comparison of adenosine perfusion (PERF), late gadolinium enhancement (LGE) and MRCA or the results of their combination has ... | 18,928,521 |
SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys. | Infection of nonhuman primates with simian immunodeficiency virus (SIV) or chimeric simian-human immunodeficiency virus (SHIV) strains is widely used to study lentiviral pathogenesis, antiviral immunity and the efficacy of AIDS vaccine candidates. SHIV challenges allow assessment of anti-HIV-1 envelope responses in pri... | 18,928,523 |
Homoeologous gene silencing in tissue cultured wheat callus. | In contrast to diploids, most polyploid plant species, which include the hexaploid bread wheat, possess an additional layer of epigenetic complexity. Several studies have demonstrated that polyploids are affected by homoeologous gene silencing, a process in which sub-genomic genomic copies are selectively transcription... | 18,928,533 |
School based screening for tuberculosis infection in Norway: comparison of positive tuberculin skin test with interferon-gamma release assay. | In Norway, screening for tuberculosis infection by tuberculin skin test (TST) has been offered for several decades to all children in 9th grade of school, prior to BCG-vaccination. The incidence of tuberculosis in Norway is low and infection with M. tuberculosis is considered rare. QuantiFERONTB Gold (QFT) is a new and... | 18,928,541 |
A candidate molecular signature associated with tamoxifen failure in primary breast cancer. | Few markers are available that can predict response to tamoxifen treatment in estrogen receptor (ER)-positive breast cancers. Identification of such markers would be clinically useful. We attempted to identify molecular markers associated with tamoxifen failure in breast cancer. Eighteen initially ER-positive patients ... | 18,928,543 |
Insulin sensitivity is normalized in the third generation (F3) offspring of developmentally programmed insulin resistant (F2) rats fed an energy-restricted diet. | The offspring and grandoffspring of female rats fed low protein diets during pregnancy and lactation, but fed nutritionally adequate diets thereafter, have been shown to exhibit altered insulin sensitivity in adulthood. The current study investigates the insulin sensitivity of the offspring and grandoffspring of female... | 18,928,547 |
A qualitative exploration of prescription opioid injection among street-based drug users in Toronto: behaviours, preferences and drug availability. | There is evidence of a high prevalence of prescription opioid (PO) and crack use among street drug users in Toronto. The purpose of this qualitative study was to describe drug use behaviours and preferences as well as the social and environmental context surrounding the use of these drugs among young and old street-bas... | 18,928,556 |
Bladder incarceration following anterior external fixation of a traumatic pubic symphysis diastasis treated with immediate open reduction and internal fixation. | Anterior pelvic ring disruptions are often associated with injuries to the genitourinary structures with the potential for considerable resultant morbidity. Herniation of the bladder into the symphyseal region after injury with subsequent entrapment upon reduction of the symphyseal diastasis has seldom been reported i... | 18,928,569 |
[Immunoregulatory effect of mesenchymal stem cells on active T lymphocytes]. | This study was purposed to explore the immunoregulatory effects of human bone marrow mesenchymal stem cells (MSCs) on active T lymphocytes in vitro and the new strategy to prevent graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Mononuclear cells from human peripheral ... | 18,928,608 |
[Effect of PD-L1 blockade on function of dendritic cells derived from chronic myelocytic leukemia]. | Programmed death-1 ligand-1(PD-L1) is a recently identified member of the B7 family molecules and is shown to mediate the inhibition of immune responses. This study was purposed to enhance the weak immunological function of dendritic cells (DCs) derived from the patients with chronic myelocytic leukemia (CML) by blocka... | 18,928,614 |
Biological activity of DC-CIK cells and its effect against leukemia cells in vitro. | This study was aimed to investigate the effect of dendritic cells (DC) on the proliferation capability, immunophenotype changes, level of secreted cytokines and activity against leukemia of cytokine-induced killer (CIK) cells in vitro. DCs and CIK cells were induced from peripheral blood mononuclear cells of healthy vo... | 18,928,615 |
[Construction and selection of the most efficient siRNA interfering plasmid specific to mouse Qa-1 gene]. | This study was purposed to construct three siRNA eukaryotic expression vector specific to mouse Qa-1 gene, to investigate its silencing effect on Qa-1 gene and to select the most efficient siRNA plasmid specific to mouse Qa-1 gene. Three siRNA peptides specific to mouse Qa-1 through siRNA Web design tools of Ambion com... | 18,928,620 |
[GFP used as a reporter system for optimization of K562 cell transfection]. | This study was aimed to obtain higher efficiency in gene transfection into K562 cells and to study the role of green fluorescence protein (GFP) as a reporter system. Transfection efficiencies with different methods including electroporation and lipofectamine 2000 transfection, were observed and calculated under fluores... | 18,928,621 |
[Effect of prefreezing parameters on human platelet cryopreservation]. | This study was aimed to investigate the effect of prefreezing parameters such as freezing rate, annealing, rate, annealing temperature, holding time in annealing before lyophilization on lyophilized platelets by orthogonal tests. The recovery rate, the morphological and ultrastructural changes, the activation and aggre... | 18,928,628 |
[Curative effect of rhIL-11 on 26 patients with chromic idiopathic thrombocytopenic purpura]. | Traditional treatment of chronic idiopathic thrombocytopenic purpura (CITP) is usually adopted as hormonal therapy. If necessary, it also can be given immunosuppressive therapy. In order to investigate the curative effect of rhIL-11 on patients with ITP, 26 patients were divided into control group and rhIL-11 group, ea... | 18,928,632 |
[Clinical significance of Helicobacter pylori in pathogenesis of idiopathic thrombocytopenic purpura]. | This study was purposed to investigate the infection incidence of Helicobacter pylori (HP) in patients with idiopathic thrombocytopenic purpura (ITP) and curative efficacy of glucocorticoids combined with anti-helicobacter. 100 ITP patients with positive HP were divided randomly into 3 groups: glucocorticoid group (tre... | 18,928,633 |
Morphological study of fibroblasts treated with cytochalasin D and colchicine using a confocal laser scanning microscopy. | The role of actin filaments and microtubules in 3D cell morphology was investigated using confocal laser scanning microscopy and image analysis based on a region-growing method. Fibroblasts were treated with cytochalasin D or colchicine to disrupt the actin filaments or microtubules, respectively, and the structure and... | 18,928,641 |
Notch signaling in pediatric malignancies. | Notch signaling plays crucial roles in many developmental pathways, with Notch mutations linked to several developmental disorders. Because many pediatric malignancies arise from dysregulated development, roles for Notch signaling in these cancers are to be expected. Evidence to support this is now emerging as the Notc... | 18,928,660 |
Pediatric developmental therapies: interesting new drugs now in early-stage clinical trials. | The current high cure rates for children diagnosed with cancer can be attributed in part to emphasis on large cooperative group clinical trials. The significant improvement in pediatric cancer survival over the past few decades is the result of optimized chemotherapy drug dosing, timing, and intensity; however, further... | 18,928,662 |
Human papillomavirus testing for primary cervical cancer screening. | With our understanding of human papillomavirus (HPV) and cervical cancer, the availability of HPV testing, and the known limitations of cervical cytology, it is time to reassess cervical cancer screening technologies. This article reviews recent randomized trials comparing primary HPV testing with cervical cytology in ... | 18,928,670 |
[Ontogenic development of the incudostapedial joint]. | To study the development of the incudostapedial joint in human embryos and foetuses. 46 temporal bones with specimens between 9 mm and newborns were studied. The preparations were sliced serially and dyed using the Martins trichrome technique. The incudostapedial joint takes on the characteristics of a spheroidal joint... | 18,928,674 |
[Congenital disorder of glycosylation type 1b. Experience with mannose treatment]. | Congenital disorders of glycosylation (CDG) are recessively inherited multisystemic disorders resulting from several genetic defects affecting the assembly, transfer or processing of oligosaccharides onto proteins and other glycoconjugates. CDG type Ib is due to a deficiency of phosphomannose isomerase (PMI) encoded by... | 18,928,705 |
[Hemoglobin Stanleyville II [alpha78(EF7)Asn --> Lys]. First case described in Spain]. | Structural hemoglobinopathies are the result of mutations in the genes of globin, which determine a qualitative alteration in the expression of these genes. Most alterations do not originate any significant change, and correspond to silent or asymptomatic forms. This study proves a new case of hemoglobin (Hb) Stanleyvi... | 18,928,738 |
[Obesity in the history of surgery]. | Obesity is a problem that is reaching epidemic proportions throughout the world and bariatric surgery is now a rapidly growing technique. However existence of obesity in humans has been recognized for thousands of years, as statues dating from the Stone Age period appear to provide the earliest depictions. Hippocrates ... | 18,928,768 |
Drug-eluting stents in the real world: how intravascular ultrasound can improve clinical outcome. | Although the benefits of drug-eluting stents for the treatment of native coronary lesions in patients undergoing percutaneous coronary interventions have been demonstrated in multiple clinical trials, there remains concern about the risk of late stent thrombosis. The MATRIX registry, a prospective study designed to ref... | 18,928,789 |
Drug-eluting stents and antiplatelet resistance. | Resistance to the antiplatelet effects of both aspirin and clopidogrel is common and is associated with poorer clinical outcomes in patients receiving antiplatelet therapy. Available data indicate that hyporesponsiveness to clopidogrel is overcome in some patients by increasing the loading dose from 300 mg to 600 mg, w... | 18,928,790 |
[Osteoporosis and the orthopaedic surgeon in 2007]. | Despite advances in the prevention and treatment of fragility fractures, their prevalence continues to grow. The identification and treatment of osteoporosis in these high-risk patients are widely reported to be inadequate. The results of the 2002 and 2006 "Orthopaedic Surgeon Survey" under the auspice of BJD and IOF h... | 18,928,797 |
Preventing cancer. | Advancements in management protocols and chemotherapeutics have improved outcomes for patients diagnosed with cancer. Cancer, however, continues to claim many lives annually in the United States and around the world. There is a large body of evidence that is strong and consistent that through modification of diet and l... | 18,928,821 |
Disease prevention and wellness in the twenty-first century. | Primary care physicians should continue their efforts in disease prevention and also should expand their scope of service to support patients' interests in wellness and health optimization. Taking on this role will require additional time and continuing education, but by knowledgeably helping patients to maximize their... | 18,928,824 |
Comparison of the anesthetic efficacy of the conventional inferior alveolar, Gow-Gates, and Vazirani-Akinosi techniques. | The purpose of this prospective, randomized study was to compare the degree of pulpal anesthesia obtained with the conventional inferior alveolar, the Gow-Gates, and the Vazirani-Akinosi techniques in vital, asymptomatic teeth. With a crossover design, 40 subjects received all 3 techniques in a random manner by using 3... | 18,928,837 |
The onset and course of binge eating in 8- to 13-year-old healthy weight, overweight and obese children. | This study aimed to (1) determine the prevalence of binge eating and overeating in 8- to 13-year-old children; (2) identify factors that cross-sectionally predict binge eating and overeating; and (3) identify factors that prospectively predict onset of binge eating and overeating. Participants were 259 boys and girls w... | 18,928,907 |
Race is a predictor of in-hospital mortality after cholecystectomy, especially in those with portal hypertension. | Cholecystectomy is the most frequently performed gastrointestinal surgery in the United States. In this study, we characterized racial disparities in in-hospital mortality after cholecystectomy among patients with and without decompensated cirrhosis. All patients who underwent cholecystectomy between 1998 and 2003 were... | 18,928,940 |
Percutaneous Impella Recover circulatory support in high-risk coronary angioplasty. | Due to the increased life expectancy derived from better conditions of life and improved medical technology, interventional cardiologists are facing challenging procedures in older and much more delicate patients, in whom percutaneous coronary intervention is generally considered less dangerous than cardiac surgery. We... | 18,928,953 |
Adverse neonatal outcomes: examining the risks between preterm, late preterm, and term infants. | There is a relative paucity of data regarding neonatal outcomes in the late preterm cohort (34 to 36 6/7 weeks). This study sought to assess differences in adverse outcomes between infants delivering 32 to 33 6/7, 34 to 36 6/7 weeks, and 37 weeks or later. Data were collected as part of a retrospective cohort study of ... | 18,928,976 |
South Carolina Partners for Preterm Birth Prevention: a regional perinatal initiative for the reduction of premature birth in a Medicaid population. | The objective of the study was to improve the distribution of preterm deliveries in a Medicaid population through a regional perinatal risk assessment and case management initiative. An innovative public/private partnership was initiated in the 8 county Lowcountry (LC) perinatal region to reduce preterm birth (PTB) amo... | 18,928,985 |
The outcome of twin-twin transfusion syndrome complicated with placental insufficiency. | The aim was to evaluate the incidence and perinatal outcomes of TTTS complicated with placental insufficiency (PI/TTTS). This was a retrospective study of all TTTS with PI. PI is defined as estimated fetal weight < 10% with elevated head circumference/abdominal circumference ratio and weight discordance > 20%. Fi... | 18,928,994 |
Assessment of some diterpenoids in commercial distilled gin. | In the present study the qualitative and quantitative determination of diterpenoids in commercial distilled gin was carried out. This widely consumed juniper-based spirit is aromatized using Juniper (Juniperus communis) berries. Although juniper reportedly contains several diterpenic compounds, no studies have addresse... | 18,929,011 |
The effectiveness of inpatient rehabilitation in the acute postoperative phase of care after transtibial or transfemoral amputation: study of an integrated health care delivery system. | To compare outcomes between lower-extremity amputees who receive and do not receive acute postoperative inpatient rehabilitation within a large integrated health care delivery system. An observational study using multivariable propensity score risk adjustment to reduce treatment selection bias. Data compiled from 9 adm... | 18,929,014 |
Impact of comorbidities on stroke rehabilitation outcomes: does the method matter? | To examine the impact of comorbidities in predicting stroke rehabilitation outcomes and to examine differences among 3 commonly used comorbidity measures--the Charlson Index, adjusted clinical groups (ACGs), and diagnosis cost groups (DCGs)--in how well they predict these outcomes. Inception cohort of patients followed... | 18,929,019 |
Winged scapula caused by a dorsal scapular nerve lesion: a case report. | Dorsal scapular nerve lesions are quite rare. A case of a 51-year-old man who had right shoulder pain, weakness of right arm elevation, and prominence of right scapula for 6 months is presented. The condition had been abruptly developed after lifting a heavy box overhead on which he felt a sharp pain in the right shoul... | 18,929,031 |
Radiological appearances of papillary breast lesions. | This review illustrates the varied appearances of benign and malignant papillary breast tumours, as identified by a breast cancer-screening programme. The commonest mammographic appearance of a papillary tumour is as a soft-tissue mass, with calcification present in less than half of cases. When calcification is presen... | 18,929,044 |
Sieving a living: a review of the biology, ecology and conservation status of the plankton-feeding basking shark Cetorhinus maximus. | The basking shark Cetorhinus maximus is the world's second largest fish reaching lengths up to 12 m and weighing up to 4 tonnes. It inhabits warm-temperate to boreal waters circumglobally and has been the subject of fisheries exploitation for at least 200 years. There is current concern over its population levels as a ... | 18,929,065 |
Hormonal influences on seizures: basic neurobiology. | There are sex differences and effects of steroid hormones, such as androgens, estrogens, and progestogens, that influence seizures. Androgens exert early organizational and later activational effects that can amplify sex/gender differences in the expression of some seizure disorders. Female-typical sex steroids, such a... | 18,929,075 |
Epilepsy in women: special considerations for adolescents. | Adolescence is a time of many changes. It is a time of growing independence, physical and emotional change, accompanied by social insecurity. Girls tend to enter puberty ahead of their male peers, growing and changing physically. Our culture tells adolescents that they are still immature, but their bodies are saying ot... | 18,929,077 |
Sexual dysfunction in women with epilepsy: role of antiepileptic drugs and psychotropic medications. | Sexual dysfunction is a frequently encountered comorbid disorder in patients with neurological and psychiatric disorders. Importantly, sexual dysfunction can also occur as a treatment emergent adverse effect of a number of commonly used psychotropic and antiepileptic medications, and can include decreased libido, erect... | 18,929,080 |
Laser therapies for glaucoma: new frontiers. | Glaucoma is a long-term ocular neuropathy defined by optic disc or retinal nerve fiber structural abnormalities and visual-field defects. Treatment for glaucoma consists of reducing intraocular pressure (IOP) to an acceptable target range to prevent further optic-nerve damage. Currently available treatments include top... | 18,929,112 |
Modern aqueous shunt implantation: future challenges. | The aqueous shunts that are currently available are based on the principles of the Molteno implant, i.e., a permanent sclerostomy, routing of aqueous to the equatorial subconjunctival space, and an end plate to prevent obstruction, and also to determine the surface area for absorption. While the Ahmed Glaucoma Valve ap... | 18,929,115 |
Anomalous palmar cutaneous branch of the median nerve in the distal forearm: case report. | Variations exist in the anatomy of the palmar cutaneous branch of the median nerve about the wrist. We report an anatomic variation in the course of the palmar cutaneous branch of the median nerve identified in a 17-year-old girl undergoing surgery for a scaphoid nonunion. Instead of coursing ulnar to the flexor carpi ... | 18,929,196 |
Desmoplastic fibroma of the hand: case report. | Desmoplastic fibroma is a benign tumor of the soft tissue and rarely of the bone. It typically presents in the trunk and proximal limbs, but it is quite rare in the hands. We present a rare case of desmoplastic fibroma of the soft tissues of the hand that presented as a slow-growing, painless, well-encapsulated mass. | 18,929,210 |
Dipeptidyl peptidase-4 as a new target of action for type 2 diabetes mellitus: a systematic review. | Type 2 diabetes mellitus is a metabolic disease leading to microvascular and macrovascular complications including coronary artery disease and stroke. Management of diabetes has been challenging, particularly in the presence of the enormous prevalence of obesity. In recent years, various inhibitors of the enzyme dipept... | 18,929,237 |
Putative golden proportions as predictors of facial esthetics in adolescents. | In orthodontics, facial esthetics is assumed to be related to golden proportions apparent in the ideal human face. The aim of the study was to analyze the putative relationship between facial esthetics and golden proportions in white adolescents. Seventy-six adult laypeople evaluated sets of photographs of 64 adolescen... | 18,929,264 |
Image distortion and spatial resolution of a commercially available cone-beam computed tomography machine. | Our objective was to evaluate images produced by a commercially available cone-beam computed tomography (CBCT) machine (i-CAT model 9140-0035-000C, Imaging Sciences International, Hatfield, Pa) for measurement and spatial resolution (ie, the ability to separate 2 objects in close proximity in the image) for all setting... | 18,929,276 |
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