title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Signal enhancement techniques for chromatography detection systems. | The Environmental Protection Act has created a growing need for the measurement and assessment of trace emissions to the environment. This encompasses three main areas of ground, water and the atmosphere. The need to achieve lower emissions has placed a large burden on analytical techniques, particularly in the areas o... | 18,924,800 |
Single standard calibration and data processing in flow injection titration based on concentration gradients. | This paper describes use of gradients of concentration generated in flow injection (FI) systems to perform determinations based on points where the concentration of titrant and analyte are at stoichiometric ratio. Two procedures were developed. In one procedure the titrant is injected in a FI manifold and merges with t... | 18,924,802 |
Application of hand-held mobility spectrometers as sensors in manufacturing industries. | Ion mobility spectrometers (IMS) are small, lightweight, extremely robust devices with low power requirements, no moving parts, no absolute requirement for gases or vacuums, that can be operated at ambient temperatures and pressures, and yet are capable of measuring vapour phase concentrations of organic chemicals at v... | 18,924,815 |
Laboratory automation -some perspectives on the challenges in the implementation of the technology in pharmaceutical development. | The intensifying pressure on reducing the development time for new pharmaceutical products is resulting in an increasing need for laboratory automation. A key element for the successful implementation of robotics for drug product analysis is the establishment of a reliable process for interaction of the automation team... | 18,924,828 |
The importance of the laboratory to the pharmaceutical business. | Understanding the contributions that the laboratory can make in product/process development, process improvement, market surveillance and general business is key to the pharmaceutical business today. Poor laboratory practice yields compliance issues, increased cost, increased cycle time and delayed product introduction... | 18,924,858 |
IFCC recommendation: The theory of reference values. Part 4. Control of analytical variation in the production, transfer and application of reference values. | This paper is the fourth in a series of Recommendations on the Theory of Reference Values. The others cover:Part 1. The Concept of Reference Values [1].Part 2. Selection of Individuals for the Production of Reference Values [2].Part 3. Preparation of Individuals and Collection of Specimens for the Production of Referen... | 18,924,909 |
On-line analyte preconcentration with atomic spectrometric detection. | Pre-concentration of analytes, or matrix removal to overcome interferences using mini- or micro-columns of exchange media prior to atomic spectrometric detection is becoming increasingly more common. This paper is a review of some of the more recent applications of chelating, ion exchange and other resins and gels that... | 18,924,915 |
Application of a computer-controlled flow analyser to the determination of glucose and to the study of beta -galactosidase activity. | Glucose was determined using an automated flow analyser and a commercial reagent preparation based on the glucose oxidaseperoxidase reaction. The coupling system for the hydrogen peroxide liberated consisted of 4-aminophenazone and 2,4-dichlorophenol. The analyser demonstrated linearity of>0.9997 for five consecutiv... | 18,924,935 |
Sequential automatic on-line determination of aquiculture nutrients: phosphate and nitrate. | A continuous-flow method for the determination of nitrate and phosphate in water is proposed. The method is based on insertion of reagents and sample solutions into a single channel through a programmable switching valve. The method depends upon heteropolyacid with phosphate and on the modified Griess reaction for nitr... | 18,924,949 |
Analytical performance of the selective multianalyser Olympus AU 5200. | The analytical performance of a selective, automatic multianalyser- the Olympus A U5200 - was tested and assessed for practicability, following ECCLSguidelines. Twenty-two analytes were tested and compared with the Olympus A U5000 analyser. A Hitachi 747 analyser was also included in this survey in order to obtain corr... | 18,924,961 |
An automated method for the determination of deoxyribonuclease activity as exemplified by fractionation of the components of the medicament Varidase. | The activity of most deoxyribonuclease enzymes can be monitored by measuring the change in absorbance at 260 nm which accompanies the breakdown of the double-stranded structure of native DNA. An automated method for determining deoxyribonuclease activity, based on such an absorbance change, which can overcome problems ... | 18,924,962 |
Automatic simultaneous determination of copper and lead in biological samples by flow injection/stripping voltammetric analysis. | An automatic-continuous method for the simultaneous determination of copper and lead based on flow injection analysis (FIA) and stripping voltammetry (SV) is proposed. The method affords the determination of the analytes at the ng/ml level (linear ranges 0.64 to 64.0 ng/ml and 2.1 to 62.2 ng/ml for copper and lead, res... | 18,924,966 |
Flow injection analysis of water. Part 1: Automatic preconcentration determination of sulphate, ammonia and iron(II)/iron(III). | This paper describes a simple flow-injection (FI) manifold for the determination of a variety of species in industrial water. The chemical systems involved in the determination of ammonia (formation of Indophenol Blue), sulfate (precipitation with Ba(II)), and iron (complexation with 1,10-phenanthroline with the help o... | 18,924,969 |
Use of a robotic station for full automation of the determination of organic matter in soil and fertilizers. | A fully automatic method for the determination of organic matter has been implemented using a robotic station. The overall process involves weighing, dilution, oxidation in very harsh working conditions (K(2)Cr(2)O(7) + concentrated H(2)SO(4)) dilution, centrifugation and photometric monitoring of the Cr(III) formed. B... | 18,924,989 |
Automation of a fixed-bed continuous-flow reactor. | This paper describes the design and operation of a laboratory plant with a fixed-bed continuous-flow reactor, fully automated and controlled from a personal computer. The automated variables include two gas flows, one liquid flow, six temperatures, two pressures, one circulation of a cooling liquid, and 10 electrovalve... | 18,924,990 |
Prejudice, segregation and immigration laws -integration of the robot into the laboratory society. | This paper addresses some serious issues about personnel morale, fears and hopes associated with and attributed to the laboratory robot. The introduction of the laboratory robot into the laboratory is examined from a managerial perspective. Human-rights and robot-rights issues are identified and addressed. Real world e... | 18,925,001 |
Introduction: Laboratory automation at Schering-Plough-increased productivity today and foundation for the future. | The following is the introductory presentation to the 1994 ISLAR meeting held in Boston from 16 to 19 October 1994. The Editor is again grateful to the organizer, the Zymark Corporation, for permission to publish the papers in the Managing Laboratory Automation Session read at ISLAR. | 18,925,010 |
Evaluation of the Coulter Counter S-Plus VI. | This article reports an evaluation of the Coulter Counter model S-Plus VI automatic analyser for haematology, and data are presented on linearity, carry-over, precision, accuracy and stability of the instrument, when compared with a model S-Plus IV/D.The three-part differential count provided by Coulter S-Plus VI has b... | 18,925,186 |
Automation in urinalysis: evaluation of three urine test strip analysers. | A clinical laboratory evaluation was conducted on the Clinitek Auto 2000, the Super Aution Analyzer and the Urotron RL9 for the determination of glucose, protein, pH, blood, ketone-bodies and bilirubin.Precision of the systems was tested using three commercial control urine materials, and reported as the percentage of ... | 18,925,198 |
Adaptation of a cold vapour mercury analyser to flow injection analysis. | Minor modifications to a Coleman MAS-50A Mercury Analyser System allowed the determination of mercury by flow injection analysis. Using sample volumes of 600 mul it was possible to analyse up to 120 samples per hour, with a detection limit of 0.2 mug. l(-1) (120 pg) of mercury. The authors also report on a simple diges... | 18,925,214 |
A novel approach to non-segmented flow analysis: Part 3. Nitrate, nitrite and ammonium in waters. | A high-performance continuous-flow analyser is used for the analysis of nitrate, nitrite and ammonium ion in potable waters. The results demonstrate that (1) the analyser allows the sequential determination of a number of analytes without requiring modification to the manifold; (2) the use of programmed slicing of the ... | 18,925,215 |
Patterns in clinical chemistry requests. | For each patient sample that is presented to the clinical chemistry laboratory a combination of various tests can be requested. This combination or profile will depend on the condition of the patient, and hence also on the requesting hospital department. Several techniques were applied to detect and describe patterns i... | 18,925,235 |
Generation of selenium hydride from alkaline solutions: a new concept of the hydride generation-atomic absorption technique. | The use of hydride generation is often useful in environmental analysis. The normal acid sodium tetrahydroborate reaction provides exceptional sensitivity with continuous flow hydride generators. In some situations there are interferences which will mask the sensitivity. An alternative chemistry system is described her... | 18,925,246 |
An evaluation of the Diamat HPLC analyser for simultaneous determination of haemoglobins A(2) and F. | The authors describe a modification of the instrumental parameters of the Diamat fully automated HPLC system for Hb A(2) assay (Bio-Rad Laboratories, Milan, Italy) in order to obtain simultaneous determination of Hb A(2) and Hb F.Hb A(2) and Hb F measurements are reproducible (within-run CV 2.6%, with Hb A(2)2.7%; 5.1%... | 18,925,255 |
Automatic continuous on-line monitoring of salicylic acid and acetylsalicylic acid in pharmaceuticals. | An asymmetrical FIA merging-zones manifold based on the dual injection of two sample microvolumes was developed for the simultaneous determination of salicylic acid and acetylsalicylic acid in pharmaceutical preparations at a sampling frequency of 30/h. The complex formed between the Fe(III) reagent continuously introd... | 18,925,284 |
Social disadvantage, stress, and alcohol use among black, Hispanic, and white Americans: findings from the 2005 U.S. National Alcohol Survey. | Despite growing evidence of the adverse health effects of social disadvantage on minority populations, few studies have investigated whether such effects extend to alcohol problems. This study examines social disadvantage as a source of stress and analyzes its association with alcohol use and problems in the three larg... | 18,925,340 |
Do patients with alcohol dependence respond to placebo? Results from the COMBINE Study. | The purpose of this study was to examine the nature of the effect of placebo medication plus accompanying medical management in the treatment of alcohol dependence. The National Institute on Alcohol Abuse and Alcoholism COMBINE (Combining Medications and Behavioral Interventions) study, a randomized controlled double-b... | 18,925,346 |
The therapeutic modulation of atherogenic dyslipidemia and inflammatory markers in the metabolic syndrome: what is the clinical relevance? | The metabolic syndrome consists of a constellation of clinical and biochemical risk factors that cluster together and heighten the risk for atherogenesis, cardiovascular diseases, and diabetes. Established risk cardiovascular factors like hypertension, atherogenic dyslipidaemia, and glucose intolerance occur in the set... | 18,925,358 |
Phylogenetic, structural and functional relationships between WD- and Kelch-repeat proteins. | The beta-propeller domain is a widespread protein organizational motif. Typically, beta-propeller proteins are encoded by repeated sequences where each repeat unit corresponds to a twisted beta-sheet structural motif; these beta-sheets are arranged in a circle around a central axis to generate the beta-propeller struct... | 18,925,367 |
Predictive CT findings of malignancy in ground-glass nodules on thin-section chest CT: the effects on radiologist performance. | Our purpose was to identify thin-section chest computed tomography (CT) findings of malignancy other than the presence of a solid portion within ground-glass nodules (GGNs) and to evaluate whether the radiologists' performance in determining malignancy can be enhanced with this information. The predictive CT findings o... | 18,925,404 |
Marfan syndrome: clinical consequences resulting from a medicolegal autopsy of a case of sudden death due to aortic rupture. | To investigate the sudden death of a 31-year-old man, a medicolegal autopsy was performed. Major findings were a dilated aortic root with a longitudinal rupture of the intima and dissection of aorta and right coronary artery and consequent tamponade of the pericardial sac. Moreover, arachnodactyly and other skeletal de... | 18,925,407 |
Identification and characterization of a serine protease inhibitor of Paragonimus westermani. | Paragonimus westermani is a trematode parasite that causes pulmonary and/or extrapulmonary granulomatous disease in humans. In this study, we identified a full-length gene encoding a novel serine protease inhibitor of P. westermani (PwSERPIN) and characterized the biochemical properties of the recombinant protein. PwSE... | 18,925,417 |
Comparing patients' and clinicians' assessment of outcomes in a randomised trial of sentinel node biopsy for breast cancer (the RACS SNAC trial). | The RACS sentinel node biopsy versus axillary clearance (SNAC) trial compared sentinel-node-based management (SNBM) and axillary lymph-node dissection (ALND) for breast cancer. In this sub study, we sought to determine whether patient ratings of arm swelling, symptoms, function and disability or clinicians' measurement... | 18,925,434 |
Sister Mary Joseph's nodule as the sole presenting feature of disseminated squamous cell cancer of the esophagus: a rare case. | Umbilical nodule due to tumor metastasis is a rare presentation which is known as Sister Joseph's nodule. This is usually due to disseminated intra abdominal malignancies which are mostly adenocarcinomas. Esophageal squamous cell cancer commonly presents with progressive dysphagia, and it usually metastasizes to liver,... | 18,925,437 |
Size and morphology of toxic oligomers of amyloidogenic proteins: a case study of human stefin B. | Amyloid-induced toxicity is a well-known phenomenon but the molecular background remains unclear. One hypothesis relates toxicity to amyloid-membrane interactions, predicting that amyloid oligomers make pores into membranes. Therefore, the toxicity and membrane interaction of prefibrillar aggregates and individual olig... | 18,925,453 |
Changes in quality attributes of intermediate-moisture raisins during storage. | The aim of this research was to determine the changes in chemical and microbiological qualities of ready-to-eat intermediate-moisture raisins during storage. Raisins were immersed into hot (98+/-1 degrees C) glucose solutions (10% w/v and 20% w/v) containing 1% (w/v) potassium sorbate to inhibit mould and yeast growth.... | 18,925,480 |
A Rorschach journey with Bruno Klopfer: clinical application and teaching. | This article is a draft of a speech given as the recipient of the 2008 Bruno Klopfer Memorial award. I review some important details of the life of Bruno Klopfer, his contributions to the scoring and interpretation of the Rorschach (Exner, 2003), and his emphasis on the use of phenomenology in the process. I then focus... | 18,925,493 |
Behavioral correlates of selected MMPI-2 clinical, content, and restructured clinical scales. | In this study, we evaluated the validity of the Restructured Clinical (RC; Tellegen et al., 2003) scales by identifying and comparing behavioral correlates of selected RC scales (RCd, RC2, RC4), their original Clinical scale counterparts (Scale 2, Scale 4), and conceptually related Content scales (DEP, ASP, CYN) in an ... | 18,925,503 |
Oxidative stress in severe dengue viral infection: association of thrombocytopenia with lipid peroxidation. | Oxidative stress in viral infections has been suggested. The study was carried out to assess the oxidative stress in the different clinical spectrums of dengue infection and to evaluate if thrombocytopenia is associated with lipid and protein oxidative injury. Twenty-seven dengue fever (DF), 32 dengue hemorrhagic fever... | 18,925,513 |
Effect of fluid therapy on prevention of acute renal failure in Bam earthquake crush victims. | At 5:28 a.m. (local time) on December 26, 2003, an earthquake measuring 6.51 on the Richter scale struck the city of Bam in the Kerman Province in southeastern Iran. Among the most important morbid events in survivors were acute renal problems. Clinical findings, laboratory data, and management of the renal victims, al... | 18,925,519 |
Chemiluminescent analysis of plasma antioxidant capacity in uremic patients undergoing hemodialysis. | Hemodialysis is a common therapeutic strategy for patients with end stage renal failure. During the hemodialytic process, the neutrophils are activated (neutrophil burst) due to the hemoincompatibility induced by hemodialysis. As a result, the activated neutrophils release reactive oxygen species (ROS), such as hydroge... | 18,925,521 |
AST-120 treatment in pre-dialysis period affects the prognosis in patients on hemodialysis. | An oral adsorbent, AST-120, has been shown to retard the deterioration of renal function in patients with chronic kidney disease (CKD) by decreasing serum nephrotoxic substances such as indoxyl sulfate. Recent studies have suggested that a high level of serum indoxyl sulfate may be one of the mechanisms underlying the ... | 18,925,523 |
Diagnostic value of the aminopeptidase N, N-acetyl-beta-D-glucosaminidase and dipeptidylpeptidase IV in evaluating tubular dysfunction in patients with glomerulopathies. | The aim of the present study was to investigate the value of the urine cell glycoprotein 1 (PC-1), aminopeptidase N (APN), N-acetyl-beta-D-glucosaminidase (NAGA), and dipeptidylpeptidase IV (DPP IV) in the evaluation of tubular damage in patients with primary glomerulonephritis, diabetic nephropathy, and lupus nephriti... | 18,925,530 |
Nebivolol reduces experimentally induced warm renal ischemia reperfusion injury in rats. | Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. The objective of the present study was to examine the role of nebivolol in modulating peroxynitrite species-induced inflammation and apoptosis after renal warm ischemia/reperfus... | 18,925,533 |
Paraneoplastic polymyositis associated with crescentic glomerulonephritis. | A female concurrently developed polymyositis (PM), lung cancer, and nephrotic range proteinuria. Renal biopsy revealed crescentic glomerulonephritis. Pathology of lung cancer was proved to be adenocarcinoma. After surgical treatment of lung cancer, the symptoms of PM-associated crescentic glomerulonephritis disappeared... | 18,925,535 |
A case of latissimus dorsi pedicle arising from the lateral thoracic vessels. | The thoracodorsal system represents a versatile, yet reliable system for the harvest of tissues for microsurgical transplantation. Also, the donor vessel anatomy is generally thought to be highly predictable in terms of topography and branching patterns. In this article we describe for the first time the occurrence of ... | 18,925,544 |
The utility of detailed first trimester ultrasound examination in abnormal fetal nuchal translucency. | To determine the value of a first trimester fetal ultrasound examination in cases of an increased nuchal translucency (NT). A detailed fetal ultrasound examination was performed within 4 days of a detection of a first trimester increased NT. As many as 23 fetuses were evaluated. Severe anomalies were detected in eight ... | 18,925,580 |
Quantification of heterocyclic amines from thermally processed meats selected from a small-scale population-based study. | Heterocyclic amines (HAs) are potent mutagens that form at high temperatures in cooked, protein-rich food. Due to their frequent intake, these compounds are considered a risk factor for human cancer. Cooking conditions and eating habits strongly influence the level of HA exposure. Thus, it is difficult to assess the in... | 18,925,613 |
Empirical test of bullies' status goals: assessing direct goals, aggression, and prestige. | The literature suggests that status goals are one of the driving motivations behind bullying behavior, yet this conjecture has rarely if ever been examined empirically. This study assessed status goals in three ways, using dyadic network analysis to analyze the relations and goals among 10-11 and 14-15 year olds in 22 ... | 18,925,635 |
Relationship between vascular endothelial growth factor and nuclear factor-kappaB in renal cell tumors. | To assess the relationship between protein and messenger RNA (mRNA) levels of vascular endothelial growth factor (VEGF) and subcellular localization of nuclear factor-kappa B (NF-kappaB), proliferation rate of tumor cells, and clinicopathological characteristics of renal cell tumors. We analyzed 31 one renal cell tumor... | 18,925,694 |
[Cortical neuron apoptosis induced by beta-amyloid peptide and protective effect of panoxadiol in mice]. | To investigate the apoptosis of cortical neurons induced by beta-amyloid peptide (Abeta(1-40)) and the protective effect of panoxadiol. The Abeta(1-40) induced damage of primarily cultured mouse cortical neurons was examined with morphological observation, MTT assay, DNA agarose gel electrophoresis and Western-blot. Af... | 18,925,710 |
[5-Lipoxygenase/cysteinyl leukotriene pathway is not involved in injury of rat C6 glioma cells induced by oxygen-glucose deprivation]. | To determine whether oxygen-glucose deprivation (OGD) induces C6 cell injury, and whether 5-lipoxygenase (5-LOX)/cysteinyl leukotriene (CysLT) pathway is involved in OGD-induced injury. After OGD treatment and recovery for various durations, the viability of C6 cells was determined, and the effects of 5-LOX inhibitors ... | 18,925,711 |
Role of the geometry, restricted rotations and solvents on the computed 2,2'-diphenyl-1-picrylhydrazyl hyperfine tensors. | The nuclear hyperfine tensor (A) components of the 2,2'-diphenyl-1-picrylhydrazyl neutral radical are computed using the UB1LYP hybrid density functional method. Solvent interactions via hydrogen bonding are found to play a crucial role in the position of the two phenyl rings relative to the picryl moiety. Under these ... | 18,925,726 |
Thermodynamics of heterogeneous crystal nucleation in contact and immersion modes. | One of the most intriguing problems of heterogeneous crystal nucleation in droplets is its strong enhancement in the contact mode (when the foreign particle is presumably in some kind of contact with the droplet surface) compared to the immersion mode (particle immersed in the droplet). Heterogeneous centers can have d... | 18,925,734 |
Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors. | Despite their structural similarities, the natural products chelerythrine ( 5) and sanguinarine ( 6) target different binding sites on the pro-survival Bcl-X L protein. This paper details the synthesis of phenanthridine-based analogues of the natural products that were used to probe this difference in binding profiles.... | 18,925,736 |
Ni(II) and hs-Fe(II) complexes of a paramagnetic thiazyl ligand, and decomposition products of the iron complex, including an Fe(III) tetramer. | Synthesis and structural, magnetic and electrochemical characterization of the Ni(hfac) 2(pyDTDA) and the Fe(hfac) 2(pyDTDA) complexes are reported (hfac = 1,1,1,5,5,5-hexafluoroacetylacetonato-; pyDTDA = 4-(2'-pyridyl)-1,2,3,5-dithiadiazolyl). Unlike the previously reported Mn(II) and Cu(II) complexes, but similar to ... | 18,925,737 |
Investigation of non-nucleophilic additives for the reduction of morphological anomalies in protein arrays. | Uniform spot morphology is of critical importance in the fabrication and successful use of protein arrays, and solution additives are often needed to ensure good spot quality. Whereas hydroxyl-bearing molecules such as glycerol have found wide use, in our experience these reduce the efficiency of probe immobilization (... | 18,925,757 |
Engineering inorganic hybrid nanoparticles: tuning combination fashions of gold, platinum, and iron oxide. | Multistep colloidal chemical routes were employed to synthesize Pt/Au, Pt/iron oxide (IO), and Au/Pt/IO hybrid nanoparticles (NPs). The starting templates, Pt NPs, were synthesized by controlling the decomposition kinetics of platinum acetylacetonate in oleylamine. The morphologies of binary metal Pt/Au hybrid NPs were... | 18,925,758 |
Arraying heterotypic single cells on photoactivatable cell-culturing substrates. | This article describes a photochemical method for the site-selective assembly of heterotypic cells on a glass substrate modified with a silane coupling agent having a caged functional group. Silane coupling agents having a carboxyl (COOH), amino (NH 2), hydroxyl (OH), or thiol (SH) group protected by a photocleavable 2... | 18,925,763 |
Peptide-mediated cellular uptake of cryptophane. | Cryptophane-A has generated considerable interest based on its high affinity for xenon and potential for creating biosensors for (129)Xe nuclear magnetic resonance (NMR) spectroscopy. Here, we report the cellular delivery of three peptide-functionalized cryptophane biosensors. Cryptophanes were delivered using two cati... | 18,925,770 |
Papillary thyroid carcinoma tall cell variant. | The most common of the aggressive variant of papillary thyroid carcinoma (PTC) is the tall cell variant (TCV). Because there are serious prognostic and management implications to a diagnosis of TCV, we review the entity to inform clinicians about the many facets of TCV. The TCV of PTC is characterized by cells having t... | 18,925,842 |
Bevacizumab: direct anti-VEGF therapy in renal cell carcinoma. | Bevacizumab, in combination with IFN, is approved in the EU as first-line therapy for advanced and/or metastatic renal cell carcinoma (mRCC). Data from Avastin and Roferon in Renal Cell Carcinoma [BO17705] (AVOREN), a Phase III trial, demonstrated that bevacizumab plus IFN significantly improves progression-free surviv... | 18,925,847 |
Management of reproductive needs in cancer patients: clinical perspectives. | Over the last few decades, a growing number of cancer survivors cured or in long-term remission following successful cancer treatment, have particular reproductive health needs. Achieving or preventing pregnancies, as well as replacement of sex hormone deficiency are three main reproductive issues. Managing such reprod... | 18,925,851 |
Molecular abnormalities in Ewing's sarcoma. | Ewing's sarcoma is one of the few solid tumors for which the underlying molecular genetic abnormality has been described: rearrangement of the EWS gene on chromosome 22q12 with an ETS gene family member. These translocations define the Ewing's sarcoma family of tumors (ESFT) and provide a valuable tool for their accura... | 18,925,858 |
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). | SGK1 (serum- and glucocorticoid-induced protein kinase 1) is a member of the AGC (protein kinase A/protein kinase G/protein kinase C) family of protein kinases and is activated by agonists including growth factors. SGK1 regulates diverse effects of extracellular agonists by phosphorylating regulatory proteins that cont... | 18,925,875 |
IgE antibodies to omega-5 gliadin associate with immediate symptoms on oral wheat challenge in Japanese children. | Gliadins have been implicated in immunoglobulin E (IgE)-mediated allergy to ingested wheat and omega-5-gliadin is known to represent a major allergen in wheat-dependent exercise-induced anaphylaxis. Less known is whether omega-5-gliadin is a clinically relevant allergen in children with immediate allergy to ingested wh... | 18,925,890 |
The programmed death (PD)-1/PD-ligand 1 pathway regulates graft-versus-host-reactive CD8 T cells after liver transplantation. | Acute graft-versus-host disease (aGVHD) is a life-threatening complication after solid-organ transplantation, which is mediated by host-reactive donor T cells emigrating from the allograft. We report on two liver transplant recipients who developed an almost complete donor chimerism in peripheral blood and bone marrow-... | 18,925,909 |
Gillies lecture: dissecting glaucoma: understanding the molecular risk factors. | WE Gillies was a major contributor to research in glaucoma, notably pseuodexfoliation (XFS), as well as strabismus, particularly in relation to axial length (AL). The latter work involved breaking down the geometry of the eye to its basic components and using the measured AL to tailor the amount of strabismus surgery r... | 18,925,913 |
Osteolipoma of the eyelid. | A 50-year-old woman presented with a nodular swelling on her right upper eyelid. The tumour was diagnosed as osteolipoma histologically after resection. Osteolipoma is a very rare variant of lipoma and only a few cases affecting the head and neck are reported in literature. To the best of the author's knowledge this is... | 18,925,915 |
Whole blood assessment of antigen specific cellular immune response by real time quantitative PCR: a versatile monitoring and discovery tool. | Monitoring of cellular immune responses is indispensable in a number of clinical research areas, including microbiology, virology, oncology and autoimmunity. Purification and culture of peripheral blood mononuclear cells and rapid access to specialized equipment are usually required. We developed a whole blood (WB) tec... | 18,925,935 |
BioVenn - a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams. | In many genomics projects, numerous lists containing biological identifiers are produced. Often it is useful to see the overlap between different lists, enabling researchers to quickly observe similarities and differences between the data sets they are analyzing. One of the most popular methods to visualize the overlap... | 18,925,949 |
Attempts at in vitro fertilization and culture of in vitro matured oocytes in sei ( Balaenoptera borealis) and Bryde's ( B. edeni) whales. | The cumulus-oocyte-complexes (COCs) recovery rates with respect to reproductive status per sei (Balaenoptera borealis) and Bryde's (B. edeni) whales were determined in Experiment 1. The number of COCs recovered ranged from 16.0 to 30.6 and from 6.7 to 26.8 per sei and Bryde's whales, respectively. The effects of COCs g... | 18,925,980 |
Why should disorders of the ear, nose and throat be treated by the same specialty? Can this situation persist? | The surgical specialty of otorhinolaryngology has its origins in the nineteenth century. Subsequently, the specialty also incorporated allied disciplines such as plastics and head and neck surgery. Following World War II, the survival of the specialty was threatened by the advent of antibiotics and the rise of the gene... | 18,925,994 |
Thyroid surgery: the sub-mental drain. | To propose an alternative site of thyroid drain placement. During thyroid surgery, post-operative drains are often placed. It is common practice to bring out the drain lateral to the wound, often creating an additional, unsightly scar. We have found excellent cosmesis is achieved by bringing out the drain in the midlin... | 18,926,000 |
Spontaneous intracranial hypotension presenting to the ENT surgeon: case report. | To highlight a case of spontaneous intracranial hypotension presenting to the ENT surgeon. We present a case report and a review of the literature concerning spontaneous intracranial hypotension. Spontaneous intracranial hypotension is a rare diagnosis, particularly to the ENT surgeon. We report a patient with tinnitus... | 18,926,003 |
Fully automated high-performance signal-to-noise ratio enhancement based on an iterative three-point zero-order Savitzky-Golay filter. | The automated processing of data from high-throughput and real-time collection procedures is becoming a pressing problem. Currently the focus is shifting to automated smoothing techniques where, unlike background subtraction techniques, very few methods exist. We have developed a filter based on the widely used and con... | 18,926,027 |
The diagnosis and misdiagnosis of tuberculosis. | There are two worlds when it comes to the diagnosis of tuberculosis (TB). One world has only smear microscopy at its disposal. There may also be some radiological facilities, usually at the patients' expense. The other world has all modern techniques available, including culture, nucleic acid amplification, molecular d... | 18,926,032 |
Comparison of MAS-PCR and GenoType MTBDR assay for the detection of rifampicin-resistant Mycobacterium tuberculosis. | Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases, the tertiary referral hospital for tuberculosis (TB) in Southern Vietnam. To develop and evaluate a simple, rapid and accurate multiplex allele specific polymerase chain reaction (MAS-PCR) test to detect rifampicin (RMP) resistance point mutations at codons 5... | 18,926,042 |
Inequalities in smoking profiles in Morocco: the role of educational level. | Cigarette smoking is increasingly associated with lower socio-economic status, indicated by lower educational levels. This association has never been investigated in Morocco. The MARTA survey was undertaken to assess tobacco use in the Moroccan population according to level of education and other socio-demographic char... | 18,926,045 |
Endothelial activation and systemic inflammation in obese asthmatic children. | Asthma and obesity are prevalent disorders, each with a significant impact on the public health. The causality relating obesity and asthma has not been established. The objective of this article is to investigate whether asthma could exacerbate the endothelial activation and to determine the relationship between system... | 18,926,053 |
[A randomized controlled trial study of pulmonary rehabilitation with respiratory physiology as the guide on prognosis in patients with chronic obstructive pulmonary disease]. | To observe the effect of pulmonary rehabilitation with respiratory physiology as guide in patients with chronic obstructive pulmonary disease (COPD). Sixty patients of severe and very severe COPD as categorized by global proposed diagnostic criteria for COPD (GOLD, 2006) were enrolled for study. They were randomly divi... | 18,926,073 |
Combined modality therapy of esophageal cancer. | Esophageal cancer is a deadly disease. Only one third of patients with localized disease experience long-term survival. Over the past 20 years, investigators have evaluated neoadjuvant strategies to improve the outcomes of surgical management. Chemotherapy and radiation have been evaluated individually and in combinati... | 18,926,094 |
An update on biochemotherapy of advanced gastric and gastroesophageal adenocarcinoma. | Gastric and gastroesophageal adenocarcinoma (GGA) are significant worldwide health problems. With most patients presenting with advanced disease, palliative chemotherapy plays a significant role in treatment. Results from recent phase III studies of cytotoxic agents in combination therapy, such as docetaxel, oxaliplati... | 18,926,099 |
Impact of age and comorbidity in myelodysplastic syndromes. | Myelodysplastic syndromes (MDS) represent a heterogeneous group of myeloid neoplasms that are preferentially diagnosed in the elderly. With the increase in older patients with MDS in the Western world and the availability of more therapeutic options, new strategies and algorithms for optimal management and treatment of... | 18,926,101 |
Dietary restraint and gestational weight gain. | To determine whether a history of preconceptional dieting and restrained eating was related to higher weight gains in pregnancy. Dieting practices were assessed among a prospective cohort of pregnant women using the Revised Restraint Scale. Women were classified on three separate subscales as restrained eaters, dieters... | 18,926,129 |
Determining the most appropriate components for a composite clinical trial outcome. | Because composite end points augment event rates, they are often thought to increase statistical power. This may not be true if the intervention has a lesser effect on some components of the composite. Consequently, treatment effect size may depend on the choice of composite. To explore this issue, we performed a meta-... | 18,926,145 |
Long-term economic outcomes associated with intensive versus moderate lipid-lowering therapy in coronary artery disease: results from the Treating to New Targets (TNT) Trial. | In 10,001 patients with stable coronary artery disease (CAD) enrolled in the Treating to New Targets (TNT) trial, 80 mg/d of atorvastatin (high-dose regimen) reduced the composite primary end point of death from CAD, nonfatal myocardial infarction, resuscitation from cardiac arrest, or stroke by 22% relative to 10 mg/d... | 18,926,150 |
Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. | Many traditional risk factors for coronary artery disease (CAD) are associated with altered autonomic function. Inflammation may provide a link between risk factors, autonomic dysfunction, and CAD. We examined the association between heart rate variability (HRV), a measure of autonomic function, and inflammation, measu... | 18,926,158 |
Diagnosis of adrenocortical tumor in a neonate by detection of elevated blood 17-hydroxyprogesterone measured as a routine neonatal screening for congenital adrenal hyperplasia: a case report. | We report herein a case of prenatally detected neonatal adrenocortical tumor (ACT). The patient was an otherwise healthy newborn girl. No signs of Beckwith-Wiedemann syndrome were identified, and her family medical history did not suggest predisposition to cancer. Computed tomography and ultrasonography after birth rev... | 18,926,198 |
Primary repair of a large incomplete sternal cleft in an asymptomatic infant with Prolene mesh. | A cleft of the sternum is a rare congenital anomaly, often diagnosed as an asymptomatic condition at birth. We present a case of a large incomplete sternal cleft in a full-term baby boy. Surgical repair of the sternum with the use of Prolene mesh was performed during the neonatal period without cardiac compression. | 18,926,203 |
Maternal tobacco smoking, obesity, and low socioeconomic status during early pregnancy in the etiology of esophageal atresia. | The etiology of the congenital malformation esophageal atresia (EA) is essentially unknown. We hypothesized that maternal tobacco smoking, obesity, and low socioeconomic status (SES) during early pregnancy might increase the risk of the fetus developing EA. A nationwide, population-based, case-control study was nested ... | 18,926,209 |
Gastric outlet obstruction in children: an overview with report of Jodhpur disease and Sharma's classification. | Gastric outlet obstruction (GOO) is overwhelmingly described as infantile hypertrophic pyloric stenosis that overshadows other causes; thereby, there is a need to develop an elaborate and comprehensive classification. We present the same and establish a new disease called primary acquired gastric outlet obstruction dur... | 18,926,227 |
From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. | Triggering receptor expressed on myeloid cells (TREM) proteins play important roles in innate and adaptive immunity. Since the discovery of TREM-1 and TREM-2 in 2000, the field has exploded over the past 8 years and currently TREM-1 is thought of as an amplifier of the immune response, while TREM-2 is believed to be a ... | 18,926,286 |
Cybr, CYTIP or CASP: an attempt to pinpoint a molecule's functions and names. | Over the last decade several groups, including ourself, have published a series of findings on a molecule expressed in leukocytes. The molecule was termed Cybr, CYTIP or CASP for its functions and PSCDBP for its binding properties. In this review we attempt to chronicle and combine the findings on the molecule to gain ... | 18,926,288 |
Interferon-alpha controls IL-17 expression in vitro and in vivo. | The type I interferons interferon alpha (IFNalpha) and IFNbeta are the first line of defense potently induced upon viral infection, and at the same time are immunomodulatory cytokines bridging innate and adaptive immunity. T cells secreting interleukin-17 (IL-17) have recently been identified to regulate neutrophil-med... | 18,926,293 |
Identification and characterization of human thymic cortical dendritic macrophages that may act as professional scavengers of apoptotic thymocytes. | We identify and characterize a special type of macrophage in the human thymic cortex that may act as professional scavengers of apoptotic thymocytes. These are large cells with clear cytoplasm, evenly distributed exclusively in the thymic cortex, and usually contain degraded nuclei in their cytoplasm. They are distinct... | 18,926,298 |
Monitoring of glucocorticoid therapy by assessment of CD14(+)CD16(+) monocytes: a case report. | Bronchiolitis obliterans with organizing pneumonia (BOOP) is a disease affecting small airways and alveoli. It is characterized by interstitial inflammation rich in foamy macrophages and by fibroblastic connective tissue expanding into the airway and alveolar lumen. We report herein on a 54-year-old male BOOP patient w... | 18,926,305 |
Benzyl alcohol and ethanol can enhance the pathogenic potential of clinical Staphylococcus epidermidis strains. | Staphylococcus epidermidis is the most frequent cause of health care-associated infections, particularly in neonates and patients with indwelling catheters. The pathogenesis of infections caused by this organism is associated with its ability to form biofilms. We hypothesized that alcohol used in skin disinfectants, as... | 18,926,307 |
Nosocomial infections after pediatric cardiac surgery. | This study examined the rate of nosocomial infection (NI) in children who underwent cardiac surgery, and also investigated the impact of postdischarge infection surveillance. Risk factors for surgical site infections (SSIs) also were evaluated. All patients who underwent open-heart cardiac surgery in the Hospital for C... | 18,926,309 |
Influenza vaccination coverage rate among high-risk children during the 2002-2003 influenza season. | Influenza vaccination is the primary method for preventing influenza and its complications. Characteristics of influenza vaccination coverage among high-risk children (HRC) during the 2002-2003 influenza season are described. Children aged 1 to 17 years continuously enrolled in private health insurance plans during the... | 18,926,312 |
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