title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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[Effect of VEGF165 and the VEGF aptamer pegaptanib (Macugen) on the protein composition of tight junctions in microvascular endothelial cells of the retina]. | VEGF signalling is deregulated in diabetic retinopathy. Therefore, VEGF inhibitors like the modified RNA-oligonucleotide pegaptanib (VEGF aptamer, Macugen) which inhibits the interaction of VEGF(165) with its receptors, are currently being discussed as therapeutic options in the treatment of diabetic retinopathy. VEGF(... | 18,951,306 |
Cloning and expression of sheep DNA methyltransferase 1 and its development-specific isoform. | Unlike the mouse embryo, where loss of DNA methylation in the embryonic nucleus leaves cleavage stage embryos globally hypomethylated, sheep preimplantation embryos retain high levels of methylation until the blastocyst stage. We have cloned and sequenced sheep Dnmt1 and found it to be highly conserved with both the hu... | 18,951,375 |
Influence of different assignment conditions on the determination of symmetric homodimeric structures with ARIA. | The ambiguous restraint for iterative assignment (ARIA) approach for NMR structure calculation is evaluated for symmetric homodimeric proteins by assessing the effect of several data analysis and assignment methods on the structure quality. In particular, we study the effects of network anchoring and spin-diffusion cor... | 18,951,392 |
Evidence-based algorithms for diagnosing and treating ventilator-associated pneumonia. | Ventilator-associated pneumonia (VAP) is widely recognized as a serious and common complication associated with high morbidity and high costs. Given the complexity of caring for heterogeneous populations in the intensive care unit (ICU), however, there is still uncertainty regarding how to diagnose and manage VAP. We r... | 18,951,395 |
Sense of coherence moderates late effects of early childhood Holocaust exposure. | This study evaluated child Holocaust survivors with an emphasis on potential protective factors facilitating participants' adaptation to post-Holocaust life. We examined Antonovsky's (1979, 1987) salutogenic paradigm, testing the mediating and moderating effect of participants' sense of coherence (SOC) on the associati... | 18,951,426 |
Quantitative neurite outgrowth measurement based on image segmentation with topological dependence. | The study of neuronal morphology and neurite outgrowth has been enhanced by the combination of imaging informatics and high content screening, in which thousands of images are acquired using robotic fluorescent microscopy. To understand the process of neurite outgrowth in the context of neuroregeneration, we used mouse... | 18,951,464 |
Cyclic neutropenia in mammals. | Cyclic neutropenia (CN) has been well documented in humans and the gray collie. A recent model of the architecture and dynamics of hematopoiesis has been used to provide insights into the mechanism of cycling of this disorder. It provides a link between the cycling period and the cells where the mutated ELA2 is express... | 18,951,469 |
Modulation of microtubule dynamics by the microtubule-associated protein 1a. | Structural microtubule-associated proteins (MAPs) interact with microtubules to regulate the various dynamic stages of microtubules. The purpose of this study was to measure the impact of myc-tagged MAP1a fragments on microtubule dynamic phases in vivo. Cells from an epithelial kidney cell line (LLCPK1) that had been p... | 18,951,470 |
Content of endoplasmic reticulum and Golgi complex membranes positively correlates with the proliferative status of brain cells. | Although the molecular and cellular basis of particular events that lead to the biogenesis of membranes in eukaryotic cells has been described in detail, understanding of the intrinsic complexity of the pleiotropic response by which a cell adjusts the overall activity of its endomembrane system to accomplish these requ... | 18,951,474 |
Fate of the nasal capsular cartilages in prenatal and perinatal tamarins (Saguinus geoffroyi) and extent of secondary pneumatization of maxillary and frontal sinuses. | Development of the nasal capsule cartilages was studied in seven Geoffroy's tamarins (Saguinus geoffroyi), including one fetus, five neonates and one infant. Four additional postnatal specimens of the genus were studied (one 5-month-old and three adults) to determine the magnitude of postnatal expansion of the paranasa... | 18,951,479 |
Spinal cord dysmyelination caused by an antiproteolipid protein IgM antibody: implications for the mechanism of central nervous system myelin formation. | Antiglycolipid IgM antibodies are known to induce formation of "wide spaced" or "expanded" myelin, a distinctive form of dysmyelination characterized by a repeat period approximately two or three times normal, which is seen also in diseases, including multiple sclerosis. To determine whether an antibody directed agains... | 18,951,490 |
Presence of the maxillary sinus in fossil Colobinae (Cercopithecoides williamsi) from South Africa. | Extant cercopithecoid monkeys, except macaques, are distinguished among primates by their lack of paranasal pneumatization, including the maxillary sinus (MS). Analysis of this structure, widespread among Eutheria, suggests that its loss occurred in the cercopithecoid common ancestor; thus, the presence of the MS in ma... | 18,951,495 |
An automated self-similarity analysis of the pulmonary tree of the Sprague-Dawley rat. | We present the results of an automated analysis of the morphometry of the pulmonary airway trees of the Sprague-Dawley rat. Our work is motivated by a need to inform lower-dimensional mathematical models to prescribe realistic boundary conditions for multiscale hybrid models of rat lung mechanics. Silicone casts were m... | 18,951,511 |
The estrous cycle modulates small leucine-rich proteoglycans expression in mouse uterine tissues. | In the pregnant mouse uterus, small leucine-rich proteoglycans (SLRPs) are drastically remodeled within a few hours after fertilization, suggesting that ovarian hormone levels modulate their synthesis and degradation. In this study, we followed by immunoperoxidase approach, the presence of four members of the SLRP fami... | 18,951,514 |
Impact of changes in life circumstances on subjective well-being in an adult population over a 3-year period. | Mental health problems are a major issue worldwide, and there is a need to further explore factors that may increase or decrease people's subjective well-being (SWB). The main aim of the present study was to extend knowledge concerning changes in cohabitation, social support or financial situation and their influence o... | 18,951,593 |
Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity. | Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is an autoimmune genetic disorder caused by mutation of the forkhead box protein 3 gene (FOXP3), a key regulator of immune tolerance. We sought to provide clinical and molecular indicators that facilitate the understanding and diagnosis of ... | 18,951,619 |
Neuro-archaeology: pre-symptomatic architecture and signature of neurological disorders. | During brain development cells divide, differentiate and migrate to their assigned targets to form synapses and active cell assemblies. This sequence is controlled both by genetic programs and environmental factors. Alterations of this sequence by mutations or environmental insults leads to the formation of misconnecte... | 18,951,639 |
Dynamic feedback between phenotype and physiology in sexually selected traits. | Theory predicts that physiological costs of producing elaborate phenotypes assure the honesty of sexually selected traits. It is generally assumed that these physiological processes drive sexually selected displays. However, a recent study by Safran and colleagues demonstrates that the manipulation of plumage ornaments... | 18,951,654 |
Spontaneous gasping increases cerebral blood flow during untreated fatal hemorrhagic shock. | Gasping has been found to be associated with improved ventilation, stroke volume, and cerebral blood flow (CBF) during untreated ventricular fibrillation. However, its effects have not been thoroughly assessed during fatal hemorrhagic shock. In this study, we hypothesized that gasping increases CBF during fatal hemorrh... | 18,951,685 |
Nitric oxide as an early marker of human embryo metabolic cleavage in ART using fresh or thawed oocytes. | To study a possible role of nitric oxide (NO) as a marker of development in the early phases of human embryo cleavage during assisted reproduction. 179 women having ART were included. 123 women used fresh oocytes and 56 oocyte thawing cycles in the Center of Reproductive Medicine, Department of Obstetrics and Gynecolog... | 18,951,688 |
Exchange of angular momentum in EMCD experiments. | In energy loss magnetic chiral dichroism (EMCD) experiments a chiral electronic transition is induced that obeys the dipole selection rule for the magnetic quantum number Deltam = +/- 1 or DeltaL(z) = +/- h. The incident plane electron wave is inelastically scattered and is detected in the diffraction plane, i.e. again... | 18,951,701 |
Emerging treatment strategies for acute myeloid leukemia (AML) in the elderly. | Acute myeloid leukemia (AML) is more prevalent in older adults, with an incidence in the United States of 17.6 per 100,000 for those 65 years of age, compared with an incidence of 1.8 per 100,000 for those <65 years of age. While there have been improvements in survival during the last decade for younger patients, p... | 18,951,721 |
Involvement of CRH-R2 receptor in eating behavior and in the response of the HPT axis in rats subjected to dehydration-induced anorexia. | Wistar rats subjected to dehydration-induced anorexia (DIA), with 2.5% NaCl solution as drinking water for 7 days, decrease by 80% their food intake and present some changes common to pair-fed food restricted rats (FFR) such as: weight loss, decreased serum leptin and expression of orexigenic arcuate peptides, increasi... | 18,951,722 |
Local delivery of osteoprotegerin may be a way of reinforcing orthodontic anchorage. | One of the most challenging problems in orthodontics is anchorage. The traditional mechanical methods of reinforcing anchorage are limited by multiple factors, but a pharmacological approach aimed at utilizing the known biological mechanisms underlying tooth movement may provide an ideal way of reinforcing orthodontic ... | 18,951,727 |
Validation of a method for the determination of sterols and triterpenes in the aerial part of Justicia anselliana (Nees) T. Anders by capillary gas chromatography. | An accurate and sensitive method, combining soxhlet extraction, solid phase-extraction and capillary gas chromatography is described for the quantitative determination of one triterpene (lupeol) and three sterols (stigmasterol, campesterol and beta-sitosterol) and the detection of another triterpene (alpha-amyrin) from... | 18,951,746 |
[Field 5. Safety practices procedures for mechanical ventilation. French-speaking Society of Intensive Care. French Society of Anesthesia and Resuscitation]. | Invasive or endotracheal mechanical ventilation can lead to numerous complications likely to burden morbidity and mortality of patients in the intensive care unit. Various safety practices for mechanical ventilation may involve intubation, the mechanical ventilation period, weaning and extubation, the use of tracheosto... | 18,951,756 |
[New autoanti-bodies in rheumatoid arthritis: anti-citrullinated protein or peptide autoanti-bodies and the others]. | New treatment strategies require that rheumatoid arthritis (RA) be diagnosed as early as possible. New diagnostic markers were required, because rheumatoid factors (RF), until now criteria for classification of RA, are not sufficiently specific and sometimes appear late, thereby limiting their diagnostic usefulness. Th... | 18,951,757 |
Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region. | By exploiting a Still-Gennari olefination of a common C11-C26 aldehyde with a C4-C10 or C1-C10 beta-ketophosphonate, three modified C2-C6 region analogues of the 22-membered macrolide dictyostatin were synthesised and evaluated in vitro for growth inhibition against a range of human cancer cell lines, including the Tax... | 18,951,787 |
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis. | Increasing efforts are directed toward finding applications for natural products and their derivatives in the treatment of human diseases. Among such products, propolis, a resinous substance produced by honey bees from various plant sources, has been found to be a promising source of potential therapeutics. In the pres... | 18,951,805 |
Periodontal impact of surgically induced dental lesions in mandibular osteodistraction: an animal study. | The objective of the study was to evaluate the impact of dental lesions on the periodontium, in a canine model of mandibular osteodistraction. In six adult male Beagle dogs, an osteotomy was made between the right second lateral incisor and canine, and a distraction device placed. The roots adjacent to the osteotomy we... | 18,951,812 |
[The Vitruvian Man: an anatomical drawing for proportions by Leonardo Da Vinci]. | The aim of the study was to find out and to analyse the text by Vitruvius which inspired the famous drawing by Leonardo da Vinci (circa 1490) kept in the Galleria dell'Accademia, in Venezia, Italy: the man inscribed in one circle and in one square. The book "de Architectura" by Vitruvius Marcus Pollio was printed sever... | 18,951,824 |
Budget impact model of rituximab after failure of one or more TNFalpha inhibitor therapies in the treatment of rheumatoid arthritis. | To estimate the budget impact implied by the introduction of rituximab after failure of one or more anti-TNFalpha therapies in the perspective of the French health care system. A Markov model reproduced the course, over 4years, of patients treated either by infliximab, etanercept, adalimumab or RTX, after failure of on... | 18,951,825 |
Formin' an invasion machine: actin polymerization in invading apicomplexans. | Apicomplexan parasites are motile and invade host cells. The force required for this is generated by an actomyosin motor. In a recent paper, Baum and colleagues suggest that the protein formin regulates the polymerization of actin at the moving junction between parasite and host cell. This finding provides novel insigh... | 18,951,846 |
Injectable fillers for facial rejuvenation: a review. | Health care practices are moving toward a more preventative focus. In addition to leading healthier lives and seeking help to eradicate disease, patients are enlisting the help of plastic surgeons to reduce the visible signs of aging. Traditionally, facial rejuvenation focused on skin tightening through resection and r... | 18,951,862 |
Identification of an inducible factor secreted by pancreatic cancer cell lines that stimulates the production of fucosylated haptoglobin in hepatoma cells. | Fucosylation is one of the most important oligosaccharide modifications and is involved in cancer and inflammation. Recently, fucosylated haptoglobin was identified as a possible tumor marker for pancreatic cancer. The molecular mechanism underlying increases in fucosylated haptoglobin in sera of patients with pancreat... | 18,951,869 |
Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells. | Activins regulate pancreatic development, differentiation and insulin secretion. Activin receptor-like kinase 7 (ALK7) has been identified as a receptor for Nodal and Activin AB and B, and is expressed in pancreatic islets and beta-cell lines. In this study, human insulin promoter was activated by Smad2, Smad3 and the ... | 18,951,876 |
Allosteric modulation of 5-HT(1A) receptors by zinc: Binding studies. | 5-HT(1A) receptors were studied via [(3)H]WAY-100635 and [(3)H]8-OH-DPAT binding to rat brain cortical membranes. We characterized the effect of zinc (Zn(2+)) on the binding properties of the 5-HT(1A) receptor. The allosteric ternary complex model was applied to determine the dissociation constant (K(A)) of Zn(2+) and ... | 18,951,909 |
Hemispheric asymmetries in discourse processing: evidence from false memories for lists and texts. | Previous research suggests that the right hemisphere (RH) may contribute uniquely to discourse and text processing by activating and maintaining a wide range of meanings, including more distantly related meanings. The present study used the word-lists false memory paradigm [Roediger, H. L., III, & McDermott, K. B. ... | 18,951,910 |
Inactivated rotavirus vaccines: a priority for accelerated vaccine development. | Live oral rotavirus vaccines have proven to be generally safe and effective to prevent severe dehydrating diarrhea among children in high and some middle income countries. However, concerns linger about rare but severe adverse events, such as intussusception and their efficacy against the full range of rotavirus seroty... | 18,951,937 |
DNA based vaccination with a cocktail of plasmids encoding immunodominant Leishmania (Leishmania) major antigens confers full protection in BALB/c mice. | Despite the lack of effective vaccines against parasitic diseases, the prospects of developing a vaccine against leishmaniasis are still high. With this objective, we have tested four DNA based candidate vaccines encoding to immunodominant leishmania antigens (LACKp24, TSA, LmSTI1 and CPa). These candidates have been p... | 18,951,941 |
Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta. | Glycogen synthase kinase-3beta (GSK-3beta) has been proposed as the main kinase able to phosphorylate tau aberrantly in Alzheimer's disease and in related tauopathies. We have previously generated a double transgenic mouse line overexpressing the enzyme GSK-3beta and tau protein carrying a triple frontotemporal dementi... | 18,951,953 |
Characterization of Bacillus stearothermophilus infA and of its product IF1. | Bacillus stearothermophilus infA encoding translation initiation factor IF1 was cloned and expressed in Escherichia coli and its transcript and protein product characterized. Although the functional properties of B. stearothermophilus and E. coli IF1, compared in several translational tests in the presence of both homo... | 18,951,960 |
Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW)F(1) mice. | Previous studies have shown that treatment of ovariectomized females with 17-beta estradiol (E2) accelerates the development of autoimmunity in the (NZBxNZW)F(1) murine lupus model. Treatment with estrogenic organochlorine pesticides (OCPs) such as chlordecone produces a similar effect. Although it is reasonable to pos... | 18,951,962 |
Evaluation of a taste sensor instrument (electronic tongue) for use in formulation development. | A taste sensor instrument (electronic tongue) was evaluated to determine its utility in developing a taste-enhanced liquid formulation. To train the electronic tongue, human sensory panel data were collected for two prototype formulations, a solution of the drug in water and several marketed products. Studies using the... | 18,951,963 |
An alternative pathway for Alu retrotransposition suggests a role in DNA double-strand break repair. | The Alu family is a highly successful group of non-LTR retrotransposons ubiquitously found in primate genomes. Similar to the L1 retrotransposon family, Alu elements integrate primarily through an endonuclease-dependent mechanism termed target site-primed reverse transcription (TPRT). Recent studies have suggested that... | 18,951,971 |
Microsclerotia development in Verticillium dahliae: Regulation and differential expression of the hydrophobin gene VDH1. | The vascular wilt fungus Verticillium dahliae produces persistent resting structures, known as microsclerotia, which are important for this plant pathogen's long-term survival. Previously, we identified a hydrophobin gene (VDH1) that is necessary for microsclerotial production. The current study of VDH1's expression, a... | 18,951,989 |
Human mitochondrial variants influence on oxygen consumption. | This work investigates if human mitochondrial variants influence on maximal oxygen consumption (VO(2max)). With this purpose we recruited, as a uniform population in term of nutritional habits and life style, 114 healthy male Spanish subjects that practiced fitness exercises 3-4 times a week. Once mtDNA haplogroups wer... | 18,952,007 |
Cesarean delivery on maternal request: the impact on mother and newborn. | Mothers should be counseled that the most concerning risks related to maternal request cesarean delivery are neonatal respiratory morbidity and those that may affect the mother's future reproductive health, including life-threatening conditions, such as placenta accreta. The literature suggests that overall risks of ma... | 18,952,018 |
Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology. | The human hypoxia-inducible factor prolyl hydroxylases 1, 2, and 3 (HIF-PHD1, -2, and -3) are thought to act as proximal sensors of cellular hypoxia by virtue of their mechanism-based dependence on molecular oxygen. These 2-oxoglutarate (2-OG) and non-heme iron-dependent oxygenases constitutively hydroxylate HIF, resul... | 18,952,043 |
Intrinsic uncoupling in the ATP synthase of Escherichia coli. | The ATP hydrolysis activity and proton pumping of the ATP synthase of Escherichia coli in isolated native membranes have been measured and compared as a function of ADP and Pi concentration. The ATP hydrolysis activity was inhibited by Pi with an half-maximal effect at 140 microM, which increased progressively up in th... | 18,952,048 |
Suppressive effects of retinoids on iron-induced oxidative stress in the liver. | We previously reported that impaired retinoid signaling in the liver causes steatohepatitis and hepatocellular carcinoma. Recently, oxidative stress induced by hepatic iron overload has emerged as an important factor for the progression of liver disease in patients with chronic hepatitis C, alcoholic liver disease, and... | 18,952,085 |
Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites. | The invasion of red blood cells (RBCs) is an essential event in the life cycle of all malaria-causing Plasmodium parasites; however, there are major gaps in our knowledge of this process. Here, we use video microscopy to address the kinetics of RBC invasion in the human malaria parasite Plasmodium falciparum. Under in ... | 18,952,091 |
Crystal structure of the erythromycin polyketide synthase dehydratase. | The dehydratases (DHs) of modular polyketide synthases (PKSs) catalyze dehydrations that occur frequently in the biosynthesis of complex polyketides, yet little is known about them structurally or mechanistically. Here, the structure of a DH domain, isolated from the fourth module of the erythromycin PKS, is presented ... | 18,952,099 |
Tracking prey or tracking the prey's resource? Mechanisms of movement and optimal habitat selection by predators. | We synthesize previous theory on ideal free habitat selection to develop a model of predator movement mechanisms, when both predators and prey are mobile. We consider a continuous environment with an arbitrary distribution of resources, randomly diffusing prey that consume the resources, and predators that consume the ... | 18,952,108 |
Expression profiles of cytokines released in intestinal epithelial cells of the rainbow trout, Oncorhynchus mykiss, in response to bacterial infection. | To determine whether fish intestinal epithelial cells (IECs) contribute to mucosal immunity, we established a method for isolating IECs from the rainbow trout Oncorhynchus mykiss and examined cytokine production in these cells. Components of the intestinal epithelium were released by incubation of intestinal pieces wit... | 18,952,122 |
The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. | The zinc finger-containing protein A20 is a negative regulator of TNF-induced JNK (c-Jun-N-terminal kinase) and NFkappaB (nuclear factor kappaB) signaling. A20 is an unusual enzyme that contains both ubiquitinating and deubiquitinating activities. Although A20 is mostly localized in the cytosol, our recent studies reve... | 18,952,128 |
MBL2 single nucleotide polymorphism diversity among four ethnic groups as revealed by a bead-based liquid array profiling. | In the present work we established a rapid, cost-effective and high-throughput method for genotyping using a multiplexed microsphere-based suspension array platform - Luminex xMAP which enabled us to analyze 3 SNPs in the MBL2 gene promoter and 5' UTR, and 3 coding SNPs exon 1 haplotypes, associated with different leve... | 18,952,132 |
Identification of an unusual AT(D)Pase-like activity in multifunctional NAD glycohydrolase from the venom of Agkistrodon acutus. | NAD-glycohydrolases (NADases) are ubiquitous enzymes that possess NAD glycohydrolase, ADPR cyclase or cADPR hydrolase activity. All these activities are attributed to the NADase-catalyzed cleavage of C-N glycosyl bond. AA-NADase purified from the venom of Agkistrodon acutus is different from the known NADases, for it c... | 18,952,139 |
Mechanisms of human inherited epilepsies. | It is just over a decade since the discovery of the first human epilepsy associated ion channel gene mutation. Since then mutations in at least 25 different genes have been described, although the strength of the evidence for these genes having a pathogenic role in epilepsy varies. These discoveries are allowing us to ... | 18,952,142 |
Genetic study of an American family with DYT3 dystonia (lubag). | X-linked dystonia-parkinsonism (XDP, DYT3), endemic in the Philippine island of Panay, is characterized by the clinical onset with dystonia followed by parkinsonism. We found a 35-year-old American male patient, originally from Panay with typical XDP, has a 2-year history of parkinsonism, dystonia, and tremor. Ancestra... | 18,952,144 |
I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation. | A decrease in orexin-A (OX-A) levels has been reported to be associated with depression. It is also well known that stress and depression can disrupt neurogenesis in the dentate gyrus of the hippocampus; however, it is unclear how OX-A is involved in depression and/or neurogenesis. In the present study, we investigated... | 18,952,152 |
Functionally modified gelatin microspheres impregnated collagen scaffold as novel wound dressing to attenuate the proteases and bacterial growth. | An attempt was made to develop a new therapeutic delivery system which would play a dual role of attenuating MMP activity in the wounds and also prevent infection by controlled delivery of antimicrobials. A catechol type MMP inhibitor 2,3-dihydroxybenzoic acid (DHBA) was conjugated to gelatin microspheres using EDC/NHS... | 18,952,165 |
High-cell density shake-flask expression and rapid purification of the large fragment of Thermus aquaticus DNA polymerase I using a new chemically and temperature inducible expression plasmid in Escherichia coli. | We have developed a new expression vector, pcI(ts) ind(+), based upon the powerful rightward promoter of bacteriophage lambda, which is controlled by a temperature-sensitive and chemically-inducible version of the lambda repressor on the same plasmid. Locating the repressor gene on the plasmid makes this vector "portab... | 18,952,180 |
Three galactose inducible promoters for use in C. neoformans var. grubii. | Cryptococcus neoformans is the causative agent of cryptococcal meningoencephalitis, most frequently occurring in immunocompromised individuals. There are three varieties of C. neoformans, var. grubii, var. neoformans, and var. gatti. Worldwide var. grubii is the most prevalent clinical isolate. However, few tools for t... | 18,952,189 |
Development of a matrix solid-phase dispersion method for the simultaneous determination of pyrethroid and organochlorinated pesticides in cattle feed. | A matrix solid-phase dispersion (MSPD) method was developed for the simultaneous extraction of 36 common pesticides and breakdown products (mostly pyrethroids and organochlorines) in cattle feed. Different parameters affecting the extraction efficiency (such as dispersing phase, clean-up adsorbent and elution volume) w... | 18,952,214 |
Quantification of N-acetyl- and N-glycolylneuraminic acids by a stable isotope dilution assay using high-performance liquid chromatography-tandem mass spectrometry. | The present report describes a method for the quantification of N-acetyl- and N-glycolylneuraminic acids without any derivatization, using their (13)C(3)-isotopologues as internal standards and a C(18) reversed-phase column modified by decylboronic acid which allows for the first time a complete chromatographic separat... | 18,952,219 |
Upregulation of protein kinase cdelta in vascular smooth muscle cells promotes inflammation in abdominal aortic aneurysm. | The development of abdominal aortic aneurysms (AAAs) involves a complex interplay of extracellular matrix degradation, inflammation, and apoptosis. We have previously shown that protein kinase Cdelta (PKCdelta) plays a critical role in vascular smooth muscle cell (vSMC) apoptosis in the setting of oxidative stresses. H... | 18,952,226 |
Norepinephrine-mediated suppression of phagocytosis by wound neutrophils. | The systemic response to injury is characterized by massive release of norepinephrine (NE) into the circulation as a result of global sympathetic activation. Multiple authors have demonstrated NE-mediated alterations in migration of circulating neutrophils to wounds. We hypothesized that NE further alters wound neutrop... | 18,952,237 |
Substance P enhances wound closure in nitric oxide synthase knockout mice. | The neuropeptide, substance P (SP), up-regulates nitric oxide production (NO). The purpose of this study was to determine whether SP enhances response to cutaneous injury in nitric oxide synthase knockout (NOS null) mice. We studied mice with targeted deletions of the 3 NOS genes, neuronal NOS, inducible NOS, or endoth... | 18,952,239 |
Detection of spatial fluctuations of non-point source fecal pollution in coral reef surrounding waters in southwestern Puerto Rico using PCR-based assays. | Human fecal contamination of coral reefs is a major cause of concern. Conventional methods used to monitor microbial water quality cannot be used to discriminate between different fecal pollution sources. Fecal coliforms, enterococci, and human-specific Bacteroides (HF183, HF134), general Bacteroides-Prevotella (GB32),... | 18,952,244 |
Speciation analysis of arsenic in terrestrial plants from arsenic contaminated area. | Arsenic speciation analysis was carried out in plants collected from arsenic contaminated area. Two plant species were chosen for the investigation: Reed Grass (Calamagrostis arundinacea) and Lady Fern (Athyrium filix-femina). To characterize arsenic species several different extraction procedures were applied includin... | 18,952,257 |
A model for simultaneous crystallisation and biodegradation of biodegradable polymers. | This paper completes the model of biodegradation for biodegradable polymers that was previously developed by Wang et al. (Wang Y, Pan J, Han X, Sinka, Ding L. A phenomenological model for the degradation of biodegradable polymers. Biomaterials 2008;29:3393-401). Crystallisation during biodegradation was not considered ... | 18,952,280 |
Assessment of biomarkers of cadmium stress in lettuce. | Laboratory and field studies have provided encouraging insights into the capacity of plants to act as biomonitors of environmental quality through the use of biomarkers. However, a better understanding of the overall process of Cd-induced senescence, describing the cascade of Cd effects in plants is needed for a select... | 18,952,284 |
OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation. | Dendritic cell-specific transmembrane protein (DC-STAMP) has been first identified as an EST in a cDNA library of human monocyte-derived dendritic cells (DC). DC-STAMP is a multimembrane spanning protein that has been implicated in skewing haematopoietic differentiation of bone marrow cells towards the myeloid lineage,... | 18,952,287 |
Nylon wool purification alters the activation of T cells. | Purification of lymphocytes, particularly T cells, is commonly performed using nylon wool. This enrichment method selectively retains B cells and some myeloid cells allowing a significantly more pure T cell population to flow through a nylon wool column. T cells purified in this fashion are assumed to be unaltered and ... | 18,952,296 |
Morphological and immunological characteristics of the bovine temporal lymph node and hemal node. | Anatomical dissection of the temporal regions of 62 cattle demonstrated that lymph nodes and hemal nodes are present in 89% of the animals (bilaterally in 65% and unilaterally in 24% of the cases). Lymph nodes accounted for 60% and hemal nodes for 40% of all examined nodes. They are nearly always round with diameters r... | 18,952,301 |
Boost first, eliminate systematic error, and individualize CTV to PTV margin when treating lymph nodes in high-risk prostate cancer. | The purpose of this report is to evaluate the movement of the planning target volume (PTV) in relation to the pelvic lymph nodes (PLNs) during treatment of high-risk prostate cancer. We reviewed the daily treatment course of ten consecutively treated patients with high-risk prostate cancer. PLNs were included in the in... | 18,952,307 |
High precision transponder localization using a novel electromagnetic positioning system in patients with localized prostate cancer. | The Micropos 4DRT system is being developed to provide accurate, precise, objective, and continuous target localization during radiotherapy. This study involves the first in vivo use of the system, aiming to evaluate the localization accuracy of this electromagnetic positioning technique compared with radiographic loca... | 18,952,311 |
[Contribution of exercise and diet in the management of knee osteoarthritis in the obese]. | Our objective was to determine whether exercise and weight loss are more effective either separately or in combination, in improving pain and physical function in obese adults with moderate knee osteoarthritis (OA). Forty-five obese adults, with a body mass index greater than 35 kg/m2 or 30<or=BMI<35 associated t... | 18,952,312 |
Payments for health care and its effect on catastrophe and impoverishment: experience from the transition to Universal Coverage in Thailand. | Equitable health financing was embodied in the reform strategies of Thailand's health care system when the country moved towards implementing the Universal Coverage (UC) policy in 2001. This study aimed to measure the pattern of household out-of-pocket payments for health care and to examine the financial catastrophe a... | 18,952,336 |
The evolving concept of health literacy. | The relationship between poor literacy skills and health status is now well recognized and better understood. Interest in this relationship has led to the emergence of the concept of health literacy. The concept has emerged from two different roots - in clinical care and in public health. This paper describes the two d... | 18,952,344 |
Objective assessment of cardiopulmonary resuscitation skills of 10-11-year-old schoolchildren using two different external chest compression to ventilation ratios. | To objectively evaluate how effectively children can perform cardiopulmonary resuscitation CPR) 2 months after a single, 2h training session and establish whether or not their performance is affected by the ratio of external chest compressions to ventilations used. Eighty-five schoolchildren aged 10-11 years old were g... | 18,952,356 |
Digalloylresveratrol, a new phenolic acid derivative induces apoptosis and cell cycle arrest in human HT-29 colon cancer cells. | Digalloylresveratrol (DIG) is a new synthetic ester of the naturally occurring polyhydroxyphenolic substances gallic acid and resveratrol which both exert anti-cancer activity in a number of tumor cell lines. The aim of the study was to identify the biochemical effects of DIG in HT-29 human colon cancer cells. DIG indu... | 18,952,370 |
The treatment of hand burns. | In more than 80% of all burns, the hand is involved. Even if a burned hand does not play a major role for the survival of a patient, its function and aesthetic appearance are of utmost importance for the re-integration into society and professional life. Adequate treatment demands a number of major decisions: necessity... | 18,952,379 |
[Hyperreactive malarial splenomegaly: three clinical cases and literature review]. | Hyperreactive malarial splenomegaly (HMS) is the chronic stage of a long-term stimulation of the immune system secondary to plasmodial infections, more frequently in genetically predisposed patients. HMS is a leading cause of large tropical splenomegaly in endemic zones but has been described in immigrants from Africa ... | 18,952,389 |
Aseptic loosening of total hip arthroplasty: preliminary genetic investigation. | Femoral and acetabular loosening can be attributed different factors, but the causes and mechanism of early failure are still obscure. The objective of this study was to investigate the relationship between gene polymorphisms and early implant failure. Fifty-eight patients older than 50 years was recruited for analysis... | 18,952,406 |
Compostable cutlery and waste management: an LCA approach. | The use of disposable cutlery in fast food restaurants and canteens in the current management scenario generates mixed heterogeneous waste (containing food waste and non-compostable plastic cutlery). The waste is not recyclable and is disposed of in landfills or incinerated with or without energy recovery. Using biodeg... | 18,952,413 |
Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors. | 5-(Trifluoroacetyl)thiophene-2-carboxamides were found to be potent and selective class II HDAC inhibitors. This paper describes their further development and the investigation on the cause for the lack of cell-based activity. A rapid screening assay was set up which enabled the identification of more metabolic stable ... | 18,952,417 |
A Spanish sporadic case of deafness-dystonia (Mohr-Tranebjaerg) syndrome with a novel mutation in the gene encoding TIMM8a, a component of the mitochondrial protein translocase complexes. | Mohr-Tranebjaerg syndrome is a rare X-linked condition characterized by the association of dystonia and progressive postlingual sensorineural hearing impairment. Here we report the clinical and genetic findings in a Spanish patient with MTS carrying a novel mutation in the DDP1 (deafness-dystonia peptide 1) gene, which... | 18,952,432 |
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM). | Peptidyl alpha-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of alpha-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of inhibitors as drugs for the treatment of human disease and as insecticides for the management of insect pests. We show h... | 18,952,446 |
Prospective randomized comparison of left atrial and biatrial radiofrequency ablation in the treatment of atrial fibrillation. | The aim of this study was to compare, in patients with permanent atrial fibrillation (AF), the efficacy and safety of left atrial ablation with that of a biatrial procedure and to assess the risk factors for late failure of sinus rhythm restoration. Between January 2004 and January 2007, 299 consecutive patients underw... | 18,952,450 |
Bioprosthetic replacement of the ascending thoracic aorta: what are the options? | Increasing patient age and improved durability of latest generation bioprostheses have stimulated the use of bioprosthetic devices in the setting of ascending aortic replacement as an alternative to mechanical valved conduits or aortic valve-sparing procedures. We performed an English literature review to assess differ... | 18,952,452 |
Expression of BCL10 is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan. | This study used an immunohistochemical technique to examine the expression of BCL10 in 93 specimens of oral squamous cell carcinoma (OSCC) and 21 specimens of normal oral mucosa (NOM). We found a significant correlation between the higher mean BCL10 labeling index (LI) and OSCCs at the tongue, with larger tumor size, w... | 18,952,491 |
Enhanced frequencies of CD14++CD16+, but not CD14+CD16+, peripheral blood monocytes in severe asthmatic patients. | CD16+ monocytes are expanded in various inflammatory conditions. Recently it was reported that CD16+ monocytes can be divided into two subsets with contrasting potential of modulating inflammatory responses, namely CD14++CD16+ and CD14+CD16+ monocytes. Here, we characterized and quantified CD14++CD16+ and CD14+CD16+ mo... | 18,952,503 |
grlA and gyrA mutations and antimicrobial susceptibility in clinical isolates of ciprofloxacin- methicillin-resistant Staphylococcus aureus. | To determine grlA and gyrA mutations in ciprofloxacin- methicillin-resistant Staphylococcus aureus isolates and their susceptibility to current antimicrobials, including a newer fluoroquinolone gatifloxacin, glycopeptides vancomycin, teicoplanin and oxazolidinone linezolid. A total of 56 methicillin-resistant S. aureus... | 18,952,518 |
Smoking and drinking habits are important predictors of Helicobacter pylori eradication. | The aim of the study was to evaluate the effect of smoking and drinking habits, in separate and joint analyses, on the efficacy of H. pylori eradication. A total of 250 patients were recruited. They were treated with a 7-day course of omeprazole, amoxicillin, tinidazole (OAT), omeprazole amoxicillin, clarithromycin (OA... | 18,952,538 |
Treatment of patients with myeloma with comorbid conditions: considerations for the clinician. | Patients with multiple myeloma (MM) frequently present with serious comorbidities such as renal impairment and/or diabetes. Treatment of these patient subsets poses a greater challenge: renal dysfunction can alter drug clearance leading to increased toxicity, and commonly used regimens can induce or exacerbate hypergly... | 18,952,546 |
Unraveling the biologic and clinical complexities of HER2. | It has been over 20 years since the discovery of the human epidermal growth factor receptor 2 (HER2), a tyrosine kinase receptor that is a potent oncoprotein in breast and other cancers and has become an opportune target for therapy. HER2 plays a critical role in normal development, forming homodimers or heterodimers w... | 18,952,552 |
Extended adjuvant endocrine therapy in breast cancer: current status and future directions. | Women with hormone receptor-positive breast cancer have traditionally been treated with 5 years of adjuvant tamoxifen to reduce their risk of subsequent recurrent disease. Among those who experience subsequent disease recurrence, the majority do so after 5 years, suggesting that longer durations of endocrine therapy mi... | 18,952,554 |
Retrospective evaluation of clinical outcomes in patients with HER2-positive advanced breast cancer progressing on trastuzumab-based therapy in the pre-lapatinib era. | Patients with HER2-positive breast cancer whose disease has become resistant to the anti-HER2 monoclonal antibody trastuzumab can benefit from lapatinib, a dual epidermal growth factor receptor/HER2 tyrosine kinase (TK) inhibitor. Before the availability of this compound, trastuzumab was often continued beyond disease ... | 18,952,558 |
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