title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Arachidonic acid cytochrome P450 epoxygenase pathway. | Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acid (EET) regioisomers, 5,6-, 8,9-, 11,12-, and 14,15-EET, that function as autacrine and paracrine mediators. EETs produce vascular relaxation by activating smooth muscle large-conductance Ca2+-activated K+ channels (BKCa). In add... | 18,952,572 |
Regression of subependymal giant cell astrocytoma with rapamycin in tuberous sclerosis complex. | The authors present a 21-year-old woman who has been receiving rapamycin for 5 months for bilateral subependymal giant cell astrocytomas. The patient was started at a dose of 0.2 mg/kg/day. Levels were maintained between 11 and 13 ng/mL. Magnetic resonance imaging of the brain 2(1/2) months after initiating rapamycin d... | 18,952,591 |
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. | S6K1 (p70S6K) is a serine kinase downstream from Akt in the insulin signaling pathway that is involved in negative feedback regulation of insulin action. S6K1 is also activated by TNF-alpha, a pro-inflammatory cytokine. However, its role remains to be characterized. In the current study, we elucidated a mechanism for S... | 18,952,604 |
Smad7 is required for the development and function of the heart. | Transforming growth factor-beta (TGF-beta) family members, including TGF-betas, activins, and bone morphogenetic proteins, exert diverse biological activities in cell proliferation, differentiation, apoptosis, embryonic development, and many other processes. These effects are largely mediated by Smad proteins. Smad7 is... | 18,952,608 |
Biliary penetration and pharmacodynamic exposure of linezolid in liver transplant patients. | The aim of the study was to assess the biliary penetration of linezolid and the probabilities of attaining optimal pharmacodynamic exposure against vancomycin-resistant enterococci (VRE) in the bile of liver transplant (LTx) patients who received linezolid for the treatment of multidrug-resistant Gram-positive hospital... | 18,952,619 |
Adipocytokines and risk of stroke in older people: a nested case-control study. | Inflammation may play an important role in atherothrombosis and in promoting cerebral damage after stroke. We hypothesized that plasma adipocytokine concentrations would be associated with risk of stroke in older people. Nested case-control study from the Prospective Study of Pravastatin in the Elderly (PROSPER). Subje... | 18,952,622 |
Coagulase-negative staphylococcal prosthetic valve endocarditis--a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study. | To describe the contemporary features of coagulase-negative staphylococcal (CoNS) prosthetic valve endocarditis (PVE). Observational study of prospectively collected data from a multinational cohort of patients with infective endocarditis. Patients with CoNS PVE were compared to patients with Staphylococcus aureus and ... | 18,952,633 |
Allele *2 of the HS1,2A enhancer of the Ig regulatory region associates with rheumatoid arthritis. | To investigate the role of the HS1,2 enhancer polymorphisms as a new candidate marker for rheumatoid arthritis (RA) and to define the possible association with autoantibody positivity and clinical outcome. Genomic DNA was obtained from two cohorts of patients with RA (100 with early RA (ERA) and 114 with longstanding R... | 18,952,640 |
The influence of socioeconomic status on the reporting of regional and widespread musculoskeletal pain: results from the 1958 British Birth Cohort Study. | This study aims to determine to what extent the reporting of pain in adulthood varies by adult socioeconomic status, whether there are additional long-term effects of socioeconomic status in childhood and whether any such relationships are mediated through adult psychological ill health. A prospective cohort study (the... | 18,952,642 |
Vascular endothelial growth factor expression by hyalocytes and its regulation by glucocorticoid. | Tumour necrosis factor-alpha (TNF-alpha) is one of the major inflammatory cytokines involved in the pathogenesis of various vitreoretinal diseases. The authors investigated the effect of hypoxia, TNF-alpha and dexamethasone on vascular endothelial growth factor (VEGF) expression by cultured hyalocytes. Hyalocytes were ... | 18,952,656 |
Harvesting keratolimbal allografts from corneoscleral buttons: a novel application of cyanoacrylate adhesive. | To describe an alternative and novel technique using cyanoacrylate glue to achieve successful limbal tissue dissection, from an organ culture media stored corneoscleral button, without an artificial anterior chamber. A donor corneoscleral button (leftover from penetrating keratoplasty) was divided into two equal semici... | 18,952,657 |
Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia. | Appearance of dyskinesia is a common problem of long-term l-DOPA treatment in Parkinson's disease patients and represents a major limitation for the pharmacological management of the motor symptoms in advanced disease stages. We have recently demonstrated that dopamine released from serotonin neurons is responsible for... | 18,952,677 |
Impact of reporting rules of biopsy Gleason score for prostate cancer. | To investigate how the biopsy Gleason score (GS) and the clinical risk classification have been changed by the reporting rules. 565 prostate biopsy specimens were reassessed. Each Gleason pattern, 1 to 5, was interpreted according to the modified Gleason grading system proposed by the International Society of Urologica... | 18,952,690 |
Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. | Perivascular adipose tissue (PVAT) inhibits vascular smooth muscle cell (VSMC) contraction and stimulates VSMC proliferation by releasing protein factors. The present study was to determine whether visfatin is involved in these paracrine actions of PVAT, and if so, to explore the underlying mechanisms. Visfatin was pre... | 18,952,695 |
Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. | Serum insulin-like growth factor (IGF) -1 is secreted mainly by the liver and circulates bound to IGF-binding proteins (IGFBPs), either as binary complexes or ternary complexes with IGFBP-3 or IGFBP-5 and an acid-labile subunit (ALS). The purpose of this study was to genetically dissect the role of IGF-1 circulatory co... | 18,952,711 |
Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity. | A novel heterodimeric three-finger neurotoxin, irditoxin, was isolated from venom of the brown treesnake Boiga irregularis (Colubridae). Irditoxin subunit amino acid sequences were determined by Edman degradation and cDNA sequencing. The crystal structure revealed two subunits with a three-finger protein fold, typical ... | 18,952,712 |
Cow/calf preweaning efficiency of Nellore and Bos taurus x Bos indicus crosses. | The objectives of this study were to determine if percentage Bos taurus (0 or 50%) of the cow had an effect on ME requirements and milk production, and to compare cow/calf efficiency among 3 mating systems. Metabolizable energy requirements were estimated during a feeding trial that encompassed a gestation and lactatio... | 18,952,743 |
Pain in patients living in Norwegian nursing homes. | The aims of this study were to describe the pain and use of pain medication in nursing home patients and examine which variables that were associated with pain. Inpatients (n = 307) older than 64 years from nursing homes were included. Pain was measured with a 4-point verbal rating scale in the self-reported group (SRG... | 18,952,745 |
Reflecting the scope and work of palliative care teams today: an action research project to modernise a national minimum data set. | The Minimum Data Set (MDS) for UK specialist palliative care services was developed in 1995 to provide annual data on palliative care services. Data collected is used for local and national purposes including service management, monitoring and audit, the commissioning of services and the development of national policy.... | 18,952,752 |
Airway epithelial-derived factor relaxes pulmonary vascular smooth muscle. | The factors controlling the pulmonary vascular resistance under physiological conditions are poorly understood. We have previously reported on an apparent cross talk between the airway and adjacent pulmonary arterial bed where a factor likely derived from the bronchial epithelial cells reduced the magnitude of agonist-... | 18,952,757 |
The pathway of oligomeric DNA melting investigated by molecular dynamics simulations. | Details of the reaction coordinate for DNA melting are fundamental to much of biology and biotechnology. Recently, it has been shown experimentally that there are at least three states involved. To clarify the reaction mechanism of the melting transition of DNA, we perform 100-ns molecular dynamics simulations of a hom... | 18,952,784 |
A quantitative model of cortical spreading depression due to purinergic and gap-junction transmission in astrocyte networks. | Spreading depression (SD), a propagating wave of electrical silence in the cortex and archicortex, involves depolarization of neurons and astrocytes for approximately 1 min, due principally to a large increase in extracellular K+. SD is accompanied by large increases in extracellular ATP and is blocked by glutamate N-m... | 18,952,785 |
The small RNA GcvB regulates sstT mRNA expression in Escherichia coli. | In Escherichia coli, the gcvB gene encodes a nontranslated RNA (referred to as GcvB) that regulates OppA and DppA, two periplasmic binding proteins for the oligopeptide and dipeptide transport systems. An additional regulatory target of GcvB, sstT, was found by microarray analysis of RNA isolated from a wild-type strai... | 18,952,787 |
Geobacter sulfurreducens contains separate C- and A-adding tRNA nucleotidyltransferases and a poly(A) polymerase. | The genome of Geobacter sulfurreducens contains three genes whose sequences are quite similar to sequences encoding known members of an RNA nucleotidyltransferase superfamily that includes tRNA nucleotidyltransferases and poly(A) polymerases. Reverse transcription-PCR using G. sulfurreducens total RNA demonstrated that... | 18,952,795 |
The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. | Gene expression programs can become activated in response to extracellular signals. One evolutionarily conserved example is binding of Wnt glycoproteins to their receptor, which triggers a signal transduction cascade that stabilizes cytoplasmic beta-catenin protein, allowing it to translocate into the nucleus. There, b... | 18,952,824 |
The N-linked oligosaccharide at Fc gamma RIIIa Asn-45: an inhibitory element for high Fc gamma RIIIa binding affinity to IgG glycoforms lacking core fucosylation. | Human leukocyte receptor IIIa (Fc gamma RIIIa) plays an important role in mediating therapeutic antibodies' antibody-dependent cellular cytotoxicity (ADCC), which is closely related to the clinical efficacy of anticancer processes in humans in vivo. The removal of the core fucose from oligosaccharides attached to the F... | 18,952,826 |
Beta-arrestin 2 is required for lysophosphatidic acid-induced NF-kappaB activation. | Lysophosphatidic acid (LPA) is a bioactive phospholipid and binds to its receptors, a family of G protein-coupled receptors (GPCR), which initiates multiple signaling cascades and leads to activation of several transcription factors, including NF-kappaB. Although LPA-induced signaling pathways have been intensively inv... | 18,952,848 |
Sensitivity analysis using elicited expert information for inference with coarsened data: illustration of censored discrete event times in the AIDS Link to Intravenous Experience (ALIVE) Study. | In this paper, the authors use the rubric of "coarsened data," of which missing and censored data are special cases, to motivate the elicitation and use of expert information for performing sensitivity analyses of censored event-time data. Elicited information is important because observed data are insufficient to esti... | 18,952,850 |
In vivo Himar1 transposon mutagenesis of Burkholderia pseudomallei. | Burkholderia psedudomallei is the etiologic agent of melioidosis, and the bacterium is listed as a potential agent of bioterrorism because of its low infectious dose, multiple infectious routes, and intrinsic antibiotic resistance. To further accelerate research with this understudied bacterium, we developed a Himar1-b... | 18,952,878 |
R93W mutation in Orai1 causes impaired calcium influx in platelets. | The intracellular Ca(2+) concentration of many nonexcitable cells is regulated by calcium store release and store-operated calcium entry (SOCE). In platelets, STIM1 was recently identified as the main calcium sensor expressed in the endoplasmic reticulum. To evaluate the role of the SOC channel moiety, Orai1, in platel... | 18,952,890 |
Evaluating relevance ranking strategies for MEDLINE retrieval. | This paper evaluates the retrieval effectiveness of relevance ranking strategies on a collection of 55 queries and about 160,000 MEDLINE((R)) citations used in the 2006 and 2007 Text Retrieval Conference (TREC) Genomics Tracks. The authors study two relevance ranking strategies: term frequency-inverse document frequenc... | 18,952,932 |
Structured product labeling improves detection of drug-intolerance issues. | This study sought to assess the value of the Health Level 7/U.S. Food and Drug Administration Structured Product Labeling (SPL) drug knowledge representation standard and its associated terminology sources for drug-intolerance (allergy) decision support in computerized provider order entry (CPOE) systems. The Regenstri... | 18,952,933 |
Glutathione S-transferase M1 and T1 polymorphisms may predict adverse effects after therapy in children with medulloblastoma. | Glutathione S-transferases (GSTs) are polymorphic enzymes that catalyze the glutathione conjugation of alkylating agents, platinum compounds, and free radicals formed by radiation used to treat medulloblastoma. We hypothesized that GST polymorphisms may be responsible, in part, for individual differences in toxicity an... | 18,952,980 |
Sir Michael Foster MD FRS (1836-1907): the rise of the British school of physiology. | In 1867 William Sharpey (1802-80), Professor of General Anatomy and Physiology at University College, London, appointed Michael Foster to the unique post of Teacher of Practical Physiology; in Britain the study of experimental physiology was dormant. In 1870 Foster accepted a Praelectorship in Physiology at Trinity Col... | 18,952,994 |
Jean Langlais (1907-91): an historical case of a blind organist with stroke-induced aphasia and Braille alexia but without amusia. | The subject of a prior report of a blind organist with aphasia and Braille alexia without amusia, published in French, has been identified as Jean Langlais. His artistic and medical history is presented, the latter via translation of the original 1987 paper. | 18,952,998 |
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. | Histone deacetylase (HDAC) inhibitors, including various benzamides and hydroxamates, are currently in clinical development for a broad range of human diseases, including cancer and neurodegenerative diseases. We recently reported the identification of a family of benzamide-type HDAC inhibitors that are relatively non-... | 18,953,021 |
Bacteriophage Mu integration in yeast and mammalian genomes. | Genomic parasites have evolved distinctive lifestyles to optimize replication in the context of the genomes they inhabit. Here, we introduced new DNA into eukaryotic cells using bacteriophage Mu DNA transposition complexes, termed 'transpososomes'. Following electroporation of transpososomes and selection for marker ge... | 18,953,026 |
Mechanisms and consequences of macrophage apoptosis in atherosclerosis. | Macrophage apoptosis is an important feature of atherosclerotic plaque development. Research directed at understanding the functional consequences of macrophage death in atherosclerosis has revealed opposing roles for apoptosis in atherosclerotic plaque progression. In early lesions, macrophage apoptosis limits lesion ... | 18,953,058 |
Interaction between antihypertensives and NSAIDs in primary care: a controlled trial. | Non-steroidal anti-inflammatory drugs (NSAIDs) may increase blood pressure (BP) and blunt the effects of many antihypertensives. It seems that NSAIDs and the antihypertensive drugs differ in their propensity to such an interaction. To determine the extent of the interaction between two antihypertensives and three NSAID... | 18,953,082 |
Antidepressant therapy during pregnancy: an insight on its potential healthcare costs. | Information on healthcare costs associated with poorly treated psychiatric disorders during and after pregnancy is limited. To compare the direct healthcare costs, during and after pregnancy, between women who continue their antidepressant therapy during the whole gestational period and those who discontinue their trea... | 18,953,084 |
Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons. | Some neurosteroids show neuroprotective action in in vitro and in vivo studies, but their interaction with apoptotic/necrotic processes has been only partially unraveled. The aim of the present study was to examine the effect of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), pregnenolone (PGL) a... | 18,953,090 |
A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary. | Polychlorinated biphenyls (PCBs) have been detected at high levels, up to hundreds of pg/ml, in human ovarian follicle fluid. The effect of PCBs on the ovary and the consequences of exposure are largely unknown. We have previously shown that PCB3 (4-chlorobiphenyl) increases the secretion of estradiol and the activity ... | 18,953,099 |
Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies. | Immunotherapies that target the amyloid-beta (Abeta) peptide in Alzheimer's disease (AD) have shown promise in animal and human studies. Although the first clinical trial was halted because of adverse reactions, this approach has been refined and additional trials are underway. Another important target in AD is the neu... | 18,953,105 |
Alzheimer disease therapeutics: perspectives from the developing world. | Although a majority of dementia patients live in middle-income and low-income countries, dementia represents an under-recognized public health burden in the developing world. Culturally and socially, it tends to be trivialized as an inevitable consequence of aging. Economic constraints are paramount, precluding the ava... | 18,953,114 |
Lessons learned from failed and discontinued clinical trials for the treatment of Alzheimer's disease: future directions. | While advances have been made in understanding the neurobiological processes underlying Alzheimer's disease (AD), few treatment options currently exist. Numerous potential therapeutic and/or preventive agents have been tested in clinical trials, yet most have failed to show a clear therapeutic benefit. The lack of effe... | 18,953,117 |
Eliminating the paper medical archive by bulk document scanning of historic folders and implementing revised workflows for scanning new documents. | We made the decision in our hospital to radically eliminate the paper archive by bulk scanning over a million medical records. This reorganization goes together with installation of new workflows for injecting information that is still captured on paper as automatically as feasible into the electronic medical record. I... | 18,953,132 |
Predictors of Plasmodium vivax malaria-induced nephropathy in young Korean men. | Plasmodium vivax malaria accounts for more than half of all malaria cases in Asia and Latin America. Despite the high prevalence of disease caused by this parasite, research into its effects (especially its renal effect) has lagged disproportionately. To investigate predictors of vivax malaria-induced nephropathy, we a... | 18,953,180 |
The identification and treatment of toxic megacolon secondary to pseudomembranous colitis. | Toxic megacolon is an infrequently occurring, potentially life-threatening complication of pseudomembranous colitis. Although toxic megacolon may be considered rare, incidence is expected to increase because of the rapidly increased prevalence of pseudomembranous colitis. This article discusses the pathophysiology, cli... | 18,953,191 |
Medication adherence self-report instruments: implications for practice and research. | After an acute cardiac event, adhering to recommendations for pharmacologic therapy is important in achieving optimal health outcomes. Considering the impressive evidence base for cardiovascular pharmacotherapy, strategies for promoting adherence are less well developed. Furthermore, accessing reliable, valid, and cost... | 18,953,213 |
Clinical and radiological outcome of patients suffering from chronic pancreatitis associated with gene mutations. | Cystic fibrosis transmembrane conductance regulator (CFTR), cationic trypsinogen gene (PRSS1), and serine protease inhibitor kazal type 1 (SPINK1) gene mutations have been associated with chronic pancreatitis (CP). The aim of this study was to compare clinical and radiological findings in sporadic CP with (CPgm) and wi... | 18,953,248 |
Assessment of the prognostic value of certain acute-phase proteins and procalcitonin in the prognosis of acute pancreatitis. | Of patients with acute pancreatitis (AP), 20% develop severe attacks that need early and intensive therapy. Yet, to administer such treatment, it is important to classify early on the patients with mild and severe pancreatitis. The aim of this study was to evaluate the role of serum amyloid A, C-reactive protein, proca... | 18,953,261 |
Inflammatory aneurysm of the thoracoabdominal aorta with associated dissection. | The inflammatory variant of aortic aneurysms has 3 unique features: marked thickening of the aneurysm wall, fibrosis of the adjacent retroperitoneum, and rigid adherence of the adjacent structures to the anterior aneurysm wall. Abdominal tenderness with or without a pulsatile abdominal mass is the most common finding, ... | 18,953,281 |
Promoting epidural analgesia for labor: 2005-2007 diffusion in Lombardia, Italy. | Since January 2005 the Regional Government of Lombardia, a large Italian region with over 1/5 of all Italian births, allocated public funds for 3 consecutive years to help provide epidural analgesia (EA) for women in labor. The aim of the present study was to evaluate the trend of diffusion of EA in the triennium 2005-... | 18,953,285 |
Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans. | Many proteins necessary for sound transduction have been identified through positional cloning of genes that cause deafness. We report here that mutations of LRTOMT are associated with profound nonsyndromic hearing loss at the DFNB63 locus on human chromosome 11q13.3-q13.4. LRTOMT has two alternative reading frames and... | 18,953,341 |
[Obesity, inflammation and insulin resistance: role of gp 130 receptor ligands]. | Obesity can be considered as a low grade inflammatory disease, characterized by increased plasma levels of proinflammatory cytokines such as tumoral necrosis factor-a (TNF-a), and acute phase reactant proteins like C-reactive protein. In this context, some cytokines of the interleukin-6 (IL-6) family have been involved... | 18,953,360 |
[Effectiveness of primary health care in the diagnosis and treatment of arterial hypertension]. | Arterial hypertension (AHT) is a significant public health problem due to its high cardiovascular morbidity and mortality and its economic and social costs. Background. To identify the prevalence of AHT detected in primary care and its degree of control; to determine the types of treatment used and factors associated w... | 18,953,361 |
[Rare diseases: medicine's challenge in the XXI Century]. | Rare diseases (RD) are receiving increasing attention within both the scientific community and society in general. Many RDs are diagnosed during paediatric age and affect the patient throughout his life, but they can also be diagnosed during adult age. Advances in the biochemical, molecular and genetic diagnosis of the... | 18,953,368 |
Reprogramming primordial germ cells into pluripotent stem cells. | Specification of primordial germ cells (PGCs) results in the conversion of pluripotent epiblast cells into monopotent germ cell lineage. Blimp1/Prmt5 complex plays a critical role in the specification and maintenance of the early germ cell lineage. However, PGCs can be induced to dedifferentiate back to a pluripotent s... | 18,953,407 |
Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus. | In all organisms the Signal Recognition Particle (SRP), binds to signal sequences of proteins destined for secretion or membrane insertion as they emerge from translating ribosomes. In Archaea and Eucarya, the conserved ribonucleoproteic core is composed of two proteins, the accessory protein SRP19, the essential GTPas... | 18,953,414 |
Mammary tumors initiated by constitutive Cdk2 activation contain an invasive basal-like component. | The basal-like subtype of breast cancer is associated with invasiveness, high rates of postsurgical recurrence, and poor prognosis. Aside from inactivation of the BRCA1 tumor-suppressor gene, little is known concerning the mechanisms that cause basal breast cancer or the mechanisms responsible for its invasiveness. Her... | 18,953,433 |
Prostate gland biopsies and prostatectomies: an Ontario community hospital experience. | Transrectal ultrasound-guided core biopsies of the prostate gland and prostatectomies have become common procedures at many community hospitals in Canada, especially in the era of serum prostate-specific antigen (PSA) screening for prostate cancer. The Gleason grading of prostate cancer in biopsies and prostatectomies ... | 18,953,449 |
Leptin levels recover normally in healthy older adults after acute diet-induced weight loss. | Involuntary weight loss affects 20% of community dwelling older adults. The underlying mechanism for this disorder is unknown. Objective is to determine if failure of older persons to regain weight is associated with elevated pro-inflammatory cytokine and leptin levels. Prospective diet intervention study. University o... | 18,953,464 |
An investigation of the effects of saccharides on the memory performance of middle-aged adults. | To investigate the effects of glucose, or a combination of saccharides, or a placebo on the memory performance of middle-aged adults. A double-blind, placebo controlled design was used. A population-based sample of 45 men and women (aged 40-63 years) completed a series of memory tasks following administration of a sing... | 18,953,465 |
Multidetector computed tomography for preoperative evaluation of vascular anatomy in living renal donors. | Currently, multidetector computed tomographic (MDCT) angiography has become a noninvasive alternative imaging modality to catheter renal angiography for the evaluation of renal vascular anatomy in living renal donors. In this study, we investigated the diagnostic accuracy of 16-slice MDCT in the preoperative assessment... | 18,953,477 |
Prevalence of hepatitis B virus genotypes in chronic carriers in Santiago, Chile. | The eight genotypes (designated A-H) of hepatitis B virus (HBV) display distinctive geographical distribution worldwide, with genotypes A, D and F frequently detected in South America. To determine the prevalence of HBV genotypes in Santiago, Chile, 131 samples from chronic carriers were used for PCR amplification, and... | 18,953,483 |
Serum total selenium status in Greek adults and its relation to age. The ATTICA study cohort. | The trace element selenium is an essential micronutrient for human health and its low levels in serum are implicated in the pathogenesis of several chronic diseases. Therefore, the determination of total selenium in serum may contribute to the assessment of the health and nutritional status of certain populations. The ... | 18,953,500 |
Serum zinc, plasma ghrelin, leptin levels, selected biochemical parameters and nutritional status in malnourished hemodialysis patients. | This study was performed to investigate the serum zinc (Zn), plasma ghrelin, leptin levels and nutritional status, and to evaluate the potential association between malnutrition and these investigated parameters in malnourished hemodialysis (HD) patients. Fifteen malnourished HD patients, aged 42.9 +/- 2.11 years, who ... | 18,953,507 |
Arteriovenous malformation of the pancreas: assessment of clinical and multislice CT features. | This study was undertaken to analyze the clinical and CT features of arteriovenous malformation (AVM) of the pancreas. Seven lesions in six consecutive patients (one woman and five men, mean age 51 years) with AVM of the pancreas who underwent multiphase contrast-enhanced CT with 0.5 or 1-mm collimation were retrospect... | 18,953,516 |
[Semen analysis: spermiogram according to WHO criteria]. | Semen analysis plays a key role in diagnostics of male infertility. Semen analysis should be done according to WHO guidelines (1999), which are currently under revision. Standard procedures of semen analysis include evaluation of sperm concentration, motility, morphology, and vitality as well as determination of round ... | 18,953,523 |
Variability in motor learning: relocating, channeling and reducing noise. | Variability in motor performance decreases with practice but is never entirely eliminated, due in part to inherent motor noise. The present study develops a method that quantifies how performers can shape their performance to minimize the effects of motor noise on the result of the movement. Adopting a statistical appr... | 18,953,531 |
Plant voltage-dependent anion channels are involved in host defense against Pseudomonas cichorii and in Bax-induced cell death. | The voltage-dependent anion channel (VDAC) is a major outer mitochondrial membrane protein. It is well documented that VDAC plays an important role in apoptosis, a kind of programmed cell death, in mammalian systems. However, little is known about the role of the plant counterpart during the process of plant-specific c... | 18,953,543 |
Quantitative parameters to compare image quality of non-invasive coronary angiography with 16-slice, 64-slice and dual-source computed tomography. | Multi-slice computed tomography (MSCT) is a non-invasive modality to visualize coronary arteries with an overall good image quality. Improved spatial and temporal resolution of 64-slice and dual-source computed tomography (DSCT) scanners are supposed to have a positive impact on diagnostic accuracy and image quality. H... | 18,953,544 |
Evaluation of the integrity of the deltoid ligament in supination external rotation ankle fractures: a systematic review of the literature. | Review the literature concerning modalities to evaluate the integrity of the deltoid ligament in patients with supination external rotation ankle fractures. The electronic databases Pubmed/Medline, CINAHL and Embase were searched from 1987 to November 2007 to identify all published original studies concerning diagnosti... | 18,953,550 |
Influence of cosmetically tinted soft contact lenses on higher-order wavefront aberrations and visual performance. | To investigate the influence of cosmetically tinted soft contact lenses on ocular higher-order aberrations and visual performance, and to analyze the relationship between these parameters after the lens wear. In 44 eyes of 22 subjects, visual acuity, contrast sensitivity under photopic and mesopic conditions, and ocula... | 18,953,556 |
Human error in strabismus surgery: quantification with a sensitivity analysis. | Reoperations are frequently necessary in strabismus surgery. The goal of this study was to analyze human-error related factors that introduce variability in the results of strabismus surgery in a systematic fashion. We identified the primary factors that influence the outcome of strabismus surgery. For each of the huma... | 18,953,557 |
Depressive symptoms and self-reported occupational injury in small and medium-sized companies. | This survey was designed to determine whether depressive symptoms had an effect on the risk of self-reported occupational injury in South Korea. We conducted a prospective follow-up survey of workers at 44 small- to medium-sized companies classified into manufacturing or service businesses; 1,350 questionnaires were us... | 18,953,561 |
Impact of the exercise mode on heart rate recovery after maximal exercise. | Heart rate recovery 1 min after exercise termination (HRR-1) is a prognostic predictor. However, the influence of the exercise mode on HRR-1 is incompletely characterised. Twenty-nine young and healthy subjects and 16 elderly patients with chronic heart failure underwent cardiopulmonary exercise testing using cycle erg... | 18,953,564 |
Molecular studies of BKCa channels in intracranial arteries: presence and localization. | Large conductance calcium-activated potassium channels (BK(ca)) are crucial for the regulation of cerebral vascular basal tone and might be involved in cerebral vasodilation relevant to migraine and stroke. We studied the differential gene expression of mRNA transcript levels and protein expression of the BK(Ca) channe... | 18,953,570 |
Whole-tree sap flow is substantially diminished by leaf herbivory. | Ecohydrological models consider the relationship between tree size and structure (especially leaf area index) and water use but generally treat herbivory as a source of unwanted noise in the data. Little is known of how insect damage to leaves influences whole-plant water use in trees. Water use is driven by environmen... | 18,953,575 |
A randomized, phase II study of preoperative plus postoperative imatinib in GIST: evidence of rapid radiographic response and temporal induction of tumor cell apoptosis. | Gastrointestinal stromal tumor (GIST) is the most common sarcoma arising in the gastrointestinal (GI) tract. Imatinib mesylate (imatinib) is efficacious in treating advanced and metastatic GIST. Patients undergoing resection of GIST realize a highly variable median disease-free survival (DFS). In the absence of prospec... | 18,953,611 |
Physical activity behaviors in women with newly diagnosed ductal carcinoma-in-situ. | Epidemiological evidence suggests that physical activity may affect breast cancer risk and other health outcomes. Little information is available regarding changes in activity after diagnosis and treatment of in-situ cancer. We enrolled 487 women with newly diagnosed ductal carcinoma-in-situ (DCIS) in a longitudinal co... | 18,953,612 |
Genotype phenotype correlations of cardiac beta-myosin heavy chain mutations in Indian patients with hypertrophic and dilated cardiomyopathy. | The aim of the current study was to determine the frequency of mutations in the beta-myosin heavy chain gene (MYH7) in a cohort of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) and their families, and to investigate correlations between genotype and phenotype. About 130 consecutive patients diagnos... | 18,953,637 |
Developing a university-workforce partnership to address rural and frontier MCH training needs: the Rocky Mountain Public Health Education Consortium (RMPHEC). | The objective of the article is to provide the socio-cultural, political, economic, and geographic conditions that justified a regional effort for training maternal and child health (MCH) professionals in the Rocky Mountain region, describe a historical account of factors that led to the development of the Rocky Mounta... | 18,953,642 |
Acculturation among three racial/ethnic groups of host and immigrant adolescents. | This study compares Latino host, Latino immigrant, Asian-American host, Asian-American immigrant and European-American host groups of adolescents with respect to four acculturation-related variables: ethnic identity exploration, ethnic identity affirmation/belonging, outgroup orientation, and American identity. Using t... | 18,953,649 |
Cytogenetic and Y chromosome microdeletion screening studies in infertile males with Oligozoospermia and Azoospermia in Southeast Turkey. | In view of the genetic risks for the next generation, the importance of careful evaluation of karyotypes and AZF microdeletions in male infertility prior to assisted reproduction is evident. In the present study, it is aimed to investigate the frequency and types of both major chromosomal abnormalities by using standar... | 18,953,646 |
Egg distributions of insect parasitoids: modelling and analysis of temporal data with host density dependence. | A simple numerical procedure is presented for the problem of estimating the parameters of models for the distribution of eggs oviposited in a host. The modelling is extended to incorporate both host density and time dependence to produce a remarkably parsimonious structure with only seven parameters to describe a data ... | 18,953,656 |
Prediction of protein structural classes using hybrid properties. | In this paper, amino acid compositions are combined with some protein sequence properties (physiochemical properties) to predict protein structural classes. We are able to predict protein structural classes using a mathematical model that combines the nearest neighbor algorithm (NNA), mRMR (minimum redundancy, maximum ... | 18,953,662 |
Pili in Gram-negative and Gram-positive bacteria - structure, assembly and their role in disease. | Many bacterial species possess long filamentous structures known as pili or fimbriae extending from their surfaces. Despite the diversity in pilus structure and biogenesis, pili in Gram-negative bacteria are typically formed by non-covalent homopolymerization of major pilus subunit proteins (pilins), which generates th... | 18,953,686 |
Tonsillectomy and breast cancer risk in the Western New York Diet Study. | Exposures during early life may affect risk of breast cancer. History of tonsillectomy has recently been associated with risk of several cancers, including cancer of the breast. We conducted a population-based case-control study of women living in Western New York from 1986 to 1991. Cases had incident, primary, patholo... | 18,953,693 |
Dendritic cell subtypes as primary targets of vaccines: the emerging role and cross-talk of pattern recognition receptors. | Preventive vaccination is the most successful approach against infectious diseases and has a great impact on world health. Vaccines operate through the activation of innate immunity that helps to stimulate antigen-specific T- and B-lymphocytes. These events are orchestrated by dendritic cells (DCs) that are able to sam... | 18,953,714 |
Maintenance of serological memory. | Long-lived plasma cells are key to maintaining long-term humoral immunity after infection or vaccination. Some vaccines and/or infections induce antibody levels that remain stable for the life of the individual. However, the mechanism whereby these long-lived plasma cells are maintained over long periods of time remain... | 18,953,719 |
Inhibition of bacterial oxidases by formamide and analogs. | The enzymatic activity of Paracoccus denitrificans cytochrome c oxidase (COX) and Escherichia coli cytochrome b(o) ubiquinol oxidase (QOX) was determined in the presence of formamide, N,N-dimethyl formamide and N,N-dimethyl acetamide. Formamide was found to inhibit the enzyme activity of the oxidases most significantly... | 18,953,727 |
Neuroprotection of GST, an extract of traditional Chinese herb, against ischemic brain injury induced by transient brain ischemia and reperfusion in rat hippocampus. | In this study, we investigated the effect of GST, an extract of Chinese traditional herb, on transient brain ischemia/reperfusion-induced neuronal cell death. Immunoblotting was used to detect the phosphorylation of MLK, JNK and c-jun. Transient (15 minutes) brain ischemia was induced by the four-vessel occlusion in Sp... | 18,953,737 |
Stability and relative validity of the Multiple Sclerosis Impact Profile (MSIP). | To examine the stability and relative validity of the Multiple Sclerosis Impact Profile (MSIP) in criterion-related groups. The MSIP is a disease-targeted health impact measure based on a selection of International Classification of Functioning, Disability and Health (ICF) aspects selected by 98 patients and medical an... | 18,953,748 |
Extensive-stage small-cell lung cancer: evolution of systemic therapy and future directions. | Extensive-stage small-cell lung cancer (ES-SCLC) is one of the most lethal malignancies, with a median overall survival of only 8-10 months with first-line chemotherapy despite response rates of 60%-80%. In the second-line setting, the prognosis is even more limited, with only 20%-30% of patients having a response and ... | 18,953,759 |
Waste processing and health. A position document of the Italian Association of Epidemiology (AIE) - May 2008. | This is a position document of the Italian Epidemiological Association (AIE) on the health hazards of waste disposal. The main objectives of the document are: 1) to support the decision makers on the safety of the existing waste treatment and disposal plants and of the planned new plants; b) to recommend protective act... | 18,953,763 |
A preliminary study investigating class characteristics in the Gurmukhi handwriting of 1st and 2nd generation Punjabis. | Gurmukhi is a written script of the Punjabi language spoken by 104 million people worldwide. It has been previously shown in a study of Punjabi residents to contain several unique class characteristics. In this paper these class characteristics and others were analysed in both 1st generation and 2nd generation Punjabi ... | 18,953,800 |
[Intraoperative cranial nerves monitoring under partial neuromuscular relaxation during cerebellopontine angle tumor resection]. | To evaluate the efficacy of multiple cranial nerves monitoring under partial Seventy elective neuromuscular relaxation during cerebellopontine angle (CPA) tumor resection. patients undergoing CPA tumor resection via microneurosurgery were randomly allocated to 2 equal groups: Group FN receiving intraoperative facial ne... | 18,953,855 |
[Testosterone impairs insulin sensitivity in 3T3-L1 adipocytes and the related nongenomic mechanisms]. | To investigate the influence of rapid nongenomic effect of androgen on the insulin sensitivity of mature adipocytes and the molecular mechanism thereof. Fetal mice [corrected] preadipocytes of the line 3T3-L1 were cultured to develop into mature adipocytes. 3T3-L1 adipocytes were pretreated with testosterone of the con... | 18,953,857 |
[Enhanced expression of caveolin-1 in articular chondrocytes in osteoarthritis]. | To study the expression level of caveolin-1 in articular chondrocytes in patients with osteoarthritis (OA), and whether catabolic factor IL-1beta stimulate caveolin-1 expression in articular chondrocytes. In human OA cartilage, caveolin-1 mRNA was investigated by quantitative real-time RT-PCR while caveolin-1 protein w... | 18,953,858 |
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