title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
[Relationship between pigment gallstone and intestinal barrier function: experiment with guinea pigs and clinical observations]. | To investigate the relationship between the intestinal barrier function and pigment gallstone formation. Ninety Guinea pigs were divided randomly into 3 groups: normal control (CON) group receiving normal forage, pigment gallstone (PS) group receiving pigment gallstone-forming forage, and intestinal mucosa protection g... | 18,953,859 |
[Effect of high viral hepatitis B virus DNA loads on vertical transmission of hepatitis B virus in late-pregnant women]. | To investigate the effect of high viral loads (HBV DNA concentration in blood > 2.0 copy/ml) on the vertical transmission of hepatitis B virus in mothers with HBV DNA positivity. Forty pregnant women with HBV DNA positivity were divided randomly, double-blindly into 2 groups: at 28 weeks of pregnancy, one group rece... | 18,953,863 |
[Expression of human spindle mitosis arrest deficiency gene in spontaneous abortion embryo tissues]. | To investigate the expression of human spindle mitosis arrest deficiency gene (hsMAD2) in spontaneous abortion embryos and the relationship between low expression of hsMAD2 and numerical chromosomal aberration. METHODS Spontaneous abortion embryo tissues were collected, including 23 cases of once spontaneous abortion t... | 18,953,867 |
[Alteration of early growth response 1 expression in gastroenterological cancers and its biological significance]. | To investigate the expression of early growth response 1 (EGR1) in gastroenterological cancers and its significance in the pathogenesis. RT-PCR was used to determine the expression of EGR1 in normal gastric mucosa tissues from 20 non-tumor patients, gastroenterological tumor tissues and matched para-cancer tissues norm... | 18,953,875 |
[Effect of non-restrictive external stent on the expression of platelet-derived growth factor in vein grafts of rabbits]. | To investigate the potential mechanism of non-restrictive external stent in preventing re-stenosis of vein grafts. Thirty-six rabbits underwent reversed bypass grafting of autologous external jugular vein into common carotid artery and then were randomly divided into two equal groups, stenting group (Group S), with an ... | 18,953,884 |
[Differential scanning calorimetry analyses of phase transformations in different nickel-titanium orthodontic wires]. | To characterize austenite, martensite and R phase temperatures as well as transition temperature ranges of the commonly used nickel-titanium (NiTi) orthodontic arch wires selected from several manufacturers. Differential scanning calorimetry (DSC) method was used to study the phase transformation temperatures and the p... | 18,953,918 |
[An experimental study on outcome of ipsilateral C7 nerve root transfer to repair the root avulsion of the brachial plexus]. | To experimentally compare the treatment outcome of the injured upper limb of the root avulsion of C5 and C6 of the brachial plexus repaired by ipsilateral C7 nerve root transfer and other three multiple nerve transfers. One hundred and twenty SD rats of simulated C5 and C6 root avulsion randomly divided into 4 groups, ... | 18,953,933 |
[A clinical analysis of 32 patients with diffuse alveolar hemorrhage in diffuse connective tissue diseases]. | To provide clues to diagnosis and treatment for diffuse alveolar hemorrhage (DAH) in patients with diffuse connective tissue diseases (CTD). To analyze retrospectively the data of clinical features, pulmonary images and bronchoalveolar lavage (BAL) in 32 patients hospitalized in Peking Union Medical College Hospital fr... | 18,953,941 |
[The clinical and laboratory features of acute promyelocytic leukemia: an analysis of 513 cases]. | To investigate the clinical and laboratory features of acute promyelocytic leukemia (APL). 513 APL patients in the last two decades were retrospectively analyzed in this research. We investigated the clinical features including age, sex, abnormality of peripheral hemogram before treatment, therapeutic effect and follow... | 18,953,948 |
[Continuous glucose monitoring in type 2 diabetes with gastroparesis]. | To observe the glucose profile in type 2 diabetic gastroparesis. 31 patients diagnosed with type 2 diabetes were enrolled into this study for measurement of gastric emptying of solids and continuous glucose monitoring to observe blood glucose levels for 72 hours on a balanced diet; the results were compared with 7 subj... | 18,953,950 |
Changing patient health-risk behavior requires new investment in primary care. | Evidence supports the effectiveness of primary care interventions to improve nutrition, increase physical activity levels, reduce alcohol intake, and stop tobacco use. However, implementing these interventions requires considerable practice expense. If we hope to change behavior to reduce chronic illness, the way we pa... | 18,953,968 |
Vacuum-assisted vaginal delivery. | The second stage of labor is a dynamic event that may require assistance when maternal efforts fail to effect delivery or when there are nonreassuring fetal heart tones. Therefore, knowing how to perform an operative vaginal delivery with forceps or vacuum is vital for family physicians who provide maternity care. Vacu... | 18,953,972 |
[The origin and molecular evolution of ionotropic glutamate receptors]. | A review of the main approaches to the revealing molecular evolution of glutamate receptors is presented. Large amount of evidences concerning the homology of glutamate-binding proteins forming the membrane channels has been accumulated. However, the knowledge of amino acid sequences of these proteins is the necessary ... | 18,953,990 |
[Fragmentomics of proteins and natural oligopeptides]. | The substantiation and definition of the term "fragmentomics" are given. Within the framework of this scientific direction, a theoretical structural and functional analysis of all possible fragments of one protein molecule was performed to determine the sites that could be potential sources of the regulatory oligopepti... | 18,953,997 |
[Mg spin determines adenosinetriphosphate energetics]. | The molecular dynamics method DFT:B3LYP (6-31G** basis set, T = 310 K) was used to study interactions between adenosinetriphosphate (ATP), ATP subsystem, and magnesium cofactor [Mg(H2O)6]2+, Mg subsystem, in water environment modeled with 78 water molecules in singlet (S) and triplet (T) states. The lowest in energy si... | 18,954,005 |
[The myosin-activating protein kinases in human myocardium: localization and content]. | Using the immunofluorescence approach, we have determined that the recently detected protein kinases, among which are RhoA-activated kinase, integrin-linked kinase, zipper interacting protein kinase, and death-associated protein kinase, which are capable of phosphorylating myosin, are localized in the Z-lines sarcomere... | 18,954,004 |
[The action of low-intensity extremely high-freguency electromagnetic radiation on growth parameters for bacteria Enterococcus hirae]. | It has been found that the exposure of Enterococcus hirae ATCC9790, grown under anaerobic conditions for 30 min or 1 h, to low-intensity (flux capacity 0.06 mW/sm2) coherent electromagnetic radiation (EMI) of extremely high-frequency 45 - 53 GHz), or millimeter waves causes a marked prolongation of the lag-growth phase... | 18,954,011 |
Development and validity of the Japanese version of body shape silhouette: relationship between self-rating silhouette and measured body mass index. | We devised new body shape silhouettes to more accurately reflect Japanese body sizes. Our aim was to assess the association between measured body mass index (BMI) and body size through self-selection of nine figure scales. This study was comprised of 4808 men and 1093 women aged 35-71 years. Subjects were asked to iden... | 18,954,027 |
Intraosseous glomus tumor of the ulna: a case report with radiographic findings and a review of the literature. | Intraosseous glomus tumors of bone are extremely rare. We report a case of an intraosseous glomus tumor of the ulna. The patient was a 25-year-old woman who had a three-month history of a palpable mass in her right forearm with spontaneous pain. Radiographs showed cortical hypertrophy and a shell-like bone formation su... | 18,954,031 |
Atomic alignment effect on the branching to ArCl* and CCl2* formation in the reaction of oriented Ar(3P2,MJ=2) + CCl4. | Atomic alignment effects for the formation of ArCl*(C) and CCl2*(A) in the reaction of Ar((3)P 2) + CCl 4 have been measured by using an oriented Ar( (3)P2, M J=2) beam at a collision energy of 0.08 eV. The emission intensity for ArCl*(C) and CCl2*(A) has been measured as a function of the magnetic orientation field di... | 18,954,032 |
Resonance Raman and resonance hyper-Raman intensities: structure and dynamics of molecular excited states in solution. | Resonance Raman scattering is discussed as a vibronic spectroscopy that can provide detailed information about the structure and dynamics of excited electronic states of molecules. The emphasis is on molecules in liquid solution. The theory of resonance Raman intensities and experimental and interpretive methods are di... | 18,954,035 |
Synthesis of N-confused tetraphenylporphyrin rhodium complexes having versatile metal oxidation states. | A variety of N-confused tetraphenylporphyrin rhodium complexes were synthesized, and their structures and physical properties were investigated. Depending on the reaction conditions, the rhodium(I), -(III), and -(IV) complexes were produced, which exemplified the versatile coordination mode of N-confused porphyrin liga... | 18,954,046 |
Calcium-catalyzed Pictet-Spengler reactions. | Pictet-Spengler reactions of m-tyramine and aldehydes produced tetrahydroisoquinolines in the presence of a catalytic amount of Ca[OCH(CF3)2]2. This reaction occurs with a variety of aryl, heteroaryl, and alkyl aldehydes, producing tetrahydroisoquinolines in high yield and with high regioselectivity. This calcium-promo... | 18,954,062 |
Unique isothermal crystallization behavior of novel polyphenylene sulfide/inorganic fullerene-like WS2 nanocomposites. | The isothermal crystallization of polyphenylene sulfide (PPS) nanocomposites with inorganic fullerene-like tungsten disulfide nanoparticles (IF-WS2) has been studied from a thermal and morphological point of view, using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), polarized optical micro... | 18,954,107 |
Theoretical investigations on the stereoselectivity of the proline catalyzed Mannich reaction in DMSO. | The stereocontrol steps of the (S)-proline catalyzed Mannich reaction of cyclohexanone, formaldehyde, and aniline were theoretically investigated. The geometries of reactants, products, and transition states were optimized using density functional theory using the B3LYP functional with the 6-31++G(d,p) basis set. The e... | 18,954,108 |
Hydrophobicity and mixing effects on select heterogeneous, water-accelerated synthetic reactions. | The influence of aqueous reaction media on organic reactions is a topic of long-standing interest, particularly as it affects the rate or selectivity of synthetic reactions. Sometimes such reactions appear homogeneous, typically in dilute solution, whereas others are obviously heterogeneous, typically in concentrated s... | 18,954,111 |
Theoretical studies of the quinolinic acid to nicotinic acid mononucleotide transformation. | Quinolinate phosphoribosyl transferase (QPRTase) is an essential enzyme that catalyzes the transformation of quinolinic acid (QA) to nicotinic acid mononucleotide (NAMN), a key step on the de novo pathway for nicotinamide adenine dinucleotide (NAD) biosynthesis. We describe herein a theoretical study of the intrinsic e... | 18,954,112 |
Phase equilibrium and nucleation in VLS-grown nanowires. | Phase diagrams accounting for capillarity and surface stress in VLS-grown nanowires have been calculated, and linearized forms for the compositions of the solid and liquid are given. The solid-vapor interfacial energy causes a significant depression of the liquidus, and the impurity concentration in the wire decreases ... | 18,954,122 |
Vertically aligned single crystal TiO2 nanowire arrays grown directly on transparent conducting oxide coated glass: synthesis details and applications. | Single-crystal one-dimensional (1D) semiconductor architectures are important in materials-based applications requiring a large surface area, morphological control, and superior charge transport. Titania has widespread utility in applications including photocatalysis, photochromism, photovoltaics, and gas sensors. Whil... | 18,954,124 |
Synthesis and strain relaxation of Ge-core/Si-shell nanowire arrays. | Analogous to planar heteroepitaxy, misfit dislocation formation and stress-driven surface roughening can relax coherency strains in misfitting core-shell nanowires. The effects of coaxial dimensions on strain relaxation in aligned arrays of Ge-core/Si-shell nanowires are analyzed quantitatively by transmission electron... | 18,954,126 |
Preparation of primary amine-based block copolymer vesicles by direct dissolution in water and subsequent stabilization by sol-gel chemistry. | A new amphiphilic biocompatible diblock copolymer, poly(epsilon-caprolactone)-block-poly(2-aminoethyl methacrylate), PCL-b-PAMA, was synthesized in three steps by (i) ring-opening polymerization of epsilon-caprolactone, (ii) end-group modification by esterification, and (iii) atom transfer radical polymerization (ATRP)... | 18,954,148 |
Chronic psychosocial factors and acute physiological responses to laboratory-induced stress in healthy populations: a quantitative review of 30 years of investigations. | This meta-analysis included 729 studies from 161 articles investigating how acute stress responsivity (including stress reactivity and recovery of hypothalamic-pituitary-adrenal [HPA] axis, autonomic, and cardiovascular systems) changes with various chronic psychosocial exposures (job stress; general life stress; depre... | 18,954,159 |
Gendered racism, psychological distress, and coping styles of African American women. | This study explores the relationship of the accumulative effect of gendered racism, the discrimination felt by African American women, on psychological distress. The study also explores whether coping serves as a mediating variable between gendered racism and psychological distress. Over 300 African American women part... | 18,954,166 |
Toward assessing traumatic events and stress symptoms in preschool children from low-income families. | Traumatic events can seriously disrupt the development of preschool children. Yet few studies capture developmentally specific examples of traumas and the expression of distress for this age group. Mothers and teachers of 138 preschoolers from low-income families were interviewed about traumatic events and completed a ... | 18,954,185 |
Two ways to be complex and why they matter: implications for attitude strength and lying. | Integrative complexity broadly measures the structural complexity of statements. This breadth, although beneficial in multiple ways, can potentially hamper the development of specific theories. In response, the authors developed a model of complex thinking, focusing on 2 different ways that people can be complex within... | 18,954,192 |
Romantic red: red enhances men's attraction to women. | In many nonhuman primates, the color red enhances males' attraction to females. In 5 experiments, the authors demonstrate a parallel effect in humans: Red, relative to other achromatic and chromatic colors, leads men to view women as more attractive and more sexually desirable. Men seem unaware of this red effect, and ... | 18,954,199 |
For better and for worse: everyday social comparisons between romantic partners. | The authors examined the frequency, direction, and impact of social comparisons between romantic partners. Comparisons were expected to occur on a daily basis, owing to regular interactions between partners. To the extent that one empathizes and shares outcomes with one's partner, one might respond more positively to u... | 18,954,201 |
It's a wonderful life: mentally subtracting positive events improves people's affective states, contrary to their affective forecasts. | The authors hypothesized that thinking about the absence of a positive event from one's life would improve affective states more than thinking about the presence of a positive event but that people would not predict this when making affective forecasts. In Studies 1 and 2, college students wrote about the ways in which... | 18,954,203 |
A boost and bounce theory of temporal attention. | What is the time course of visual attention? Attentional blink studies have found that the 2nd of 2 targets is often missed when presented within about 500 ms from the 1st target, resulting in theories about relatively long-lasting capacity limitations or bottlenecks. Earlier studies, however, reported quite the opposi... | 18,954,206 |
Placing the mnemonic model in context: diagnostic, theoretical, and clinical considerations. | The mnemonic model of posttraumatic stress disorder (PTSD) proposed by D. C. Rubin, D. Berntsen, and M. K. Bohni presents some provocative and potentially insightful ideas about this mental disorder. D. C. Rubin et al. suggested that PTSD is caused and maintained through a "pathogenic memory" (D. C. Rubin et al., 2008,... | 18,954,216 |
Evaluation practices of a major Canadian telehealth provider: lessons and future directions for the field. | The objective of this study was to assess the quality of Capital Health (Edmonton Area)'s telehealth evaluation practices. We conducted a comprehensive background literature review examining the current state of the art in telehealth evaluation. Using the Clinical, Human and Organizational, Educational, Administrative,... | 18,954,246 |
Smart wireless continence management system for persons with dementia. | Incontinence is highly prevalent in the elderly population, especially in nursing home residents with dementia. It is a distressing and costly health problem that affects not only the patients but also the caregivers. Effective continence management is required to provide quality care, and to eliminate high labor costs... | 18,954,254 |
The effect of gender and age differences on media selection in small and medium tourism enterprises. | The purpose of this study is to examine the impact that gender and age differences have on the communication media selection within the context of small and medium tourism enterprises (SMEs). Media Richness Theory (MRT) was used to assess media preferences in the firms. Using a mail questionnaire, data from 78 firms we... | 18,954,272 |
Are robots present? From motor simulation to "being there". | Even if the most sophisticated robot now available is unable to learn and move in the same way as humans, two decades of research in artificial intelligence and cognitive systems introduced the concept of embodiment: the mind has to be understood in the context of its relationship to a physical body that interacts with... | 18,954,288 |
Association between increased body mass index, calcineurin inhibitor use, and renal graft survival. | Using data from the US Renal Data System, we examined the relation between body mass index and graft survival as mediated through calcineurin inhibitor use. Adult patients who received a first kidney-only transplant, with at least 6 months' survival were classified into 5 categories (underweight, normal, overweight, ob... | 18,954,297 |
Neurologic complications after renal transplant. | Neurologic complications are a significant cause of morbidity and mortality in patients who undergo transplants. We sought to evaluate the nature and incidence of neurologic complications in patients undergoing a renal transplant. Between January 2005 and December 2007, 132 adults (35 women, 97 men; mean age, 34.32 -/+... | 18,954,301 |
A simple and rapid PCR-based method for ostrich sexing using micro amounts of DNA. | The aim of the present study is to identify ostrich sex by using polymerase chain reaction (PCR) on micro amounts of DNA from blood, bloodstain and feathers. Sixteen male and 18 female ostriches were used as test individuals. Genomic DNA as a template was extracted by the Chelex method. Ostrsex-P1 and P2 primers were d... | 18,954,377 |
Effects of melatonin implants during non-breeding season on sperm motility and reproductive parameters in Rasa Aragonesa rams. | The effect of melatonin implants administered during non-breeding season in Rasa Aragonesa rams on sperm motility parameters and other reproductive traits was assessed. In a first experiment, two Rasa Aragonesa rams were implanted (with melatonin group M), remaining other two males as control group (C). Semen of each g... | 18,954,380 |
The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center. | Several groups have reported that a fraction of severely injured patients have abnormal coagulation tests at presentation to trauma centers, even in the absence of significant crystalloid resuscitation. These patients have high mortality, but their prevalence in trauma populations is not clear from the reports. Records... | 18,954,393 |
Measurement of phosphatidylserine exposure during storage of platelet concentrates using the novel probe lactadherin: a comparison study with annexin V. | Annexin V binding to platelets (PLTs) is considered the gold standard for monitoring phosphatidylserine (PS) exposure. However, recent comparison of annexin V with the new calcium-independent PS probe lactadherin revealed that annexin V requires a certain threshold of PS exposure (2%-8%) for binding to occur. The aim o... | 18,954,406 |
Validation of an automated immunoglobulin G-only cytomegalovirus (CMV) antibody screening assay and an assessment of the risk of transfusion transmitted CMV from seronegative blood. | Cytomegalovirus (CMV) antibody donor screening assays have predominantly included both immunoglobulin G (IgG) and immunoglobulin M (IgM) detection. However, since in the majority of cases both CMV IgG and IgM are detected concomitantly during early seroconversion, CMV assays based only on IgG are now widely applied for... | 18,954,407 |
Refining the phenotype of alpha-1a Tubulin (TUBA1A) mutation in patients with classical lissencephaly. | Mutations in the alpha-1a Tubulin (TUBA1A) gene have recently been found to cause cortical malformations resemblant of classical lissencephaly but with a specific combination of features. To date, TUBA1A mutations have been described in five patients and three foetuses. Our aims were to establish how common TUBA1A muta... | 18,954,413 |
Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease. | Transcriptional dysregulation is an early, key pathogenic mechanism in Huntington's disease (HD). Therefore, gene expression analyses have biomarker potential for measuring therapeutic efficacy in pre-clinical trials, particularly those aimed at correcting gene expression abnormalities. Housekeeping genes are commonly ... | 18,954,449 |
High-fidelity correction of genomic uracil by human mismatch repair activities. | Deamination of cytosine to produce uracil is a common and potentially mutagenic lesion in genomic DNA. U*G mismatches occur spontaneously throughout the genome, where they are repaired by factors associated with the base excision repair pathway. U*G mismatches are also the initiating lesion in immunoglobulin gene diver... | 18,954,457 |
Functional architecture of Escherichia coli: new insights provided by a natural decomposition approach. | Previous studies have used different methods in an effort to extract the modular organization of transcriptional regulatory networks. However, these approaches are not natural, as they try to cluster strongly connected genes into a module or locate known pleiotropic transcription factors in lower hierarchical layers. H... | 18,954,463 |
Functional brain organization for visual search in ASD. | Although previous studies have shown that individuals with autism spectrum disorder (ASD) excel at visual search, underlying neural mechanisms remain unknown. This study investigated the neurofunctional correlates of visual search in children with ASD and matched typically developing (TD) children, using an event-relat... | 18,954,479 |
Treating knee osteoarthritis with intra-articular hyaluronans. | Intra-articular hyaluronan (HA) or hylan is approved for the treatment of osteoarthritis (OA) knee pain. The authors review here published evidence of efficacy and safety of intra-articular HA for the treatment of knee pain. Since the systemic safety of nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclo-oxygenase ... | 18,954,498 |
Occupational rhinitis in damp and moldy workplaces. | Numerous studies confirm the association between exposure to indoor air dampness and molds and different health outcomes. Of these, upper respiratory tract problems are the most commonly reported work-related symptoms in damp indoor environments. The aim of this study was to describe a clinically investigated patient s... | 18,954,502 |
Clinical assessment of a nasal decongestion test by visual analog scale in allergic rhinitis. | Nasal airflow, as measured by rhinomanometry, is frequently impaired in allergic rhinitis (AR). The decongestion test evaluates whether the application of an intranasal vasoconstrictor drug increases nasal airflow. That allergy is characterized by inflammation and that the response to the decongestion test correlates w... | 18,954,509 |
Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells. | Recent experimental and human studies have shown that hyperuricemia is associated with hypertension and cardiovascular diseases. Elevated levels of endothelin-1 (ET-1) has been regarded as one of the most powerful independent predictors of cardiovascular diseases. For investigating whether uric acidinduced vascular dis... | 18,954,524 |
Evaluation and optimization of handle design parameters of a grass trimming machine. | The grass trimming machine is a widely used agricultural machine for cutting grass by the roadside and in other areas in Malaysia. Hand-arm vibration (HAV) syndrome is very common among workers operating power tools and performing similar work for extended periods. Grass trimming involves the use of a motorized cutter ... | 18,954,544 |
Adult stem cells applied to tissue engineering and regenerative medicine. | Regeneration takes place in the body at a moment or another throughout life. Bone, cartilage, and tendons (the key components of the structure and articulation in the body) have a limited capacity for self-repair and, after traumatic injury or disease, the regenerative power of adult tissue is often insufficient. When ... | 18,954,550 |
Development of the Healthy Eating Index-2005. | The Healthy Eating Index (HEI) is a measure of diet quality as specified by Federal dietary guidance, and publication of the Dietary Guidelines for Americans 2005 necessitated its revision. An interagency working group based the HEI-2005 on the food patterns found in My-Pyramid. Diets that meet the least restrictive of... | 18,954,580 |
Providing obesity prevention counseling to children during a primary care clinic visit: results from a pilot study. | The purpose of this study was to evaluate parent response to a clinic-based primary prevention intervention to increase the proportion of 5- to 10-year-old children receiving annual body mass index screening and counseling about physical activity, dietary practices, and sedentary practices. A posttest-only, quasiexperi... | 18,954,581 |
Increased invasion through basement membrane by CXCL7-transfected breast cells. | CXC chemokines may modify breast cancer cells and surrounding extracellular matrix to facilitate metastasis. CXCL7 is heparin binding, has heparanase activity, and is a ligand to CXCR2, a G-protein-linked receptor. Isogenic cell lines, malignant MCF10CA1a.cl1 cells, and premalignant MCF10AT cells were used. CXCR2 and C... | 18,954,601 |
Pexelizumab in ischemic heart disease: a systematic review and meta-analysis on 15,196 patients. | Pexelizumab is a humanized monoclonal antibody inhibiting C5 complement. It has been postulated to improve outcomes in patients undergoing coronary artery bypass surgery and urgent reperfusion therapy for ST elevation myocardial infarction. We aimed at evaluating the risk/benefit profile of pexelizumab (bolus + infusio... | 18,954,626 |
Measurement of technical performance in surgery for congenital heart disease: the stage I Norwood procedure. | No method of measuring technical performance exists for the stage I Norwood procedure. Hospital mortality is usually used as a surrogate for technical performance, but evidence is lacking to support this concept. A technical score was designed by expert consensus. The technical score included the following steps: (1) S... | 18,954,641 |
Analgesia for the critically ill dog or cat: an update. | Acute pain reliably accompanies severe illness and injury, and when sufficiently severe, it can complicate the recovery of critically ill patients. Because acute pain is closely tied to the neurologic process of nociception, pharmacologic therapy is often essential and effective. This update focuses on two methods of t... | 18,954,688 |
Neuropathic pain in dogs and cats: if only they could tell us if they hurt. | Neuropathic pain is difficult to diagnose in veterinary patients because they are unable to verbalize their pain. By assuming that neuropathic pain may exist based on the history of events that each patient has experienced, a focused client history and neurologic examination may identify a lesion resulting in persisten... | 18,954,689 |
Antimicrobial management of sepsis and septic shock. | Every patient who has sepsis and septic shock must be evaluated appropriately at presentation before the initiation of antibiotic therapy. However, in most situations, an abridged initial assessment focusing on critical diagnostic and management planning elements is sufficient. Intravenous antibiotics should be adminis... | 18,954,702 |
Prognostic systems for lymphomas. | The prognostication of lymphoma patients remains important to optimize treatments choices. Clinically based indices, such as the International Prognosis Index and the Follicular Lymphoma International Prognosis Index, developed respectively for aggressive and follicular lymphoma, are of great value in routine practice ... | 18,954,740 |
New drugs for the treatment of lymphoma. | Historically, most drugs developed for treatment of leukemias, lymphomas, and myeloma had already been studied in the solid tumor setting. Nearly 10 years ago, chronic myelogenous leukemia (CML) forever changed this paradigm. Imatinib showed that it was possible to nullify the pathognomic genetic lesion in a hematologi... | 18,954,749 |
Rapid diagnostic methods in sexually transmitted infections. | Sexually transmitted infections (STIs) are common infections throughout the developed and the developing world. It is estimated that worldwide there are 1 million new cases per day of curable bacterial STIs. As part of the World Health Organization 2001 Sexually Transmitted Diseases Diagnostics Initiative, the organiza... | 18,954,754 |
Optimal surgical performance attenuates physiologic risk in high-acuity operations. | The interplay between baseline physiology, operative performance, and postoperative recovery is poorly defined. We describe the beneficial effect of a successful operation on outcomes across the full spectrum of physiologic risk for an elective high-acuity procedure. Four hundred twelve consecutive pancreatic resection... | 18,954,785 |
Laparoscopic resection of benign hepatic cysts: a new standard. | We sought to evaluate the feasibility and outcomes of laparoscopic resection of symptomatic hepatic cysts. Fifty-one patients underwent laparoscopic resections for symptomatic hepatic cysts. Resection was accomplished laparoscopically with an Endo-GIA vascular stapler. Data were collected in a prospective database. Med... | 18,954,786 |
Individualized treatment for iron-deficiency anemia in adults. | Iron deficiency is one of the most common disorders affecting humans, and iron-deficiency anemia continues to represent a major public health problem worldwide. It is especially common among women of childbearing age because of pregnancy and menstrual blood loss. Additional patient groups include those with other sourc... | 18,954,837 |
Clinical milestones predict symptom remission over 6-month and choice of treatment of patients with major depressive disorder (MDD). | It is uncertain as to what short-term outcomes predict long-term treatment compliance and outcomes in patients with MDD. To determine what treatment milestones predict symptom remission with long-term treatment with antidepressant medication. Pooled analysis of four randomised, double-blind, active comparator, 6-month ... | 18,954,875 |
Infection risk assessment of diarrhea-related pathogens in a tropical canal network. | A quantitative microbial risk assessment (QMRA) of Cryptosporidium, Giardia and diarrhegenic Escherichia coli (DEC) infection was performed using Monte Carlo simulations to estimate the human health risks associated with the use of canal water for recreational purposes, unrestricted and restricted irrigation in a tropi... | 18,954,895 |
Status of the glass sponge reefs in the Georgia Basin. | The purpose of this paper is to describe the status and general faunal composition of sponge reefs in the Georgia Basin (GB), British Columbia, Canada. Fourteen distinct deep-water glass sponge (Hexactinellid) reefs have been mapped using multibeam bathymetry and sidescan sonar in the GB. Seven of these have been surve... | 18,954,900 |
The use of seclusion in the Netherlands compared to countries in and outside Europe. | The use of seclusion in psychiatric practice is a contentious issue in the Netherlands as well as other countries in and outside Europe. The aim of this study is to describe Dutch seclusion data and compare these with data on other countries, derived from the literature. An extensive search revealed only 11 articles co... | 18,954,906 |
GABA, a natural immunomodulator of T lymphocytes. | gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low... | 18,954,912 |
Patterns of care and outcome in elderly cervical cancer patients: a special focus on brachytherapy. | The mean age of the general population has been prolonged and the incidence of cancer in elderly patients has increased. The purpose was to evaluate outcome of brachytherapy (BT) as an integrated part of the treatment of elderly patients with cervical cancer. From November 1997 to January 2006, 1073 patients diagnosed ... | 18,954,913 |
An in vivo investigative protocol for HDR prostate brachytherapy using urethral and rectal thermoluminescence dosimetry. | To develop an in vivo dosimetry based investigative action level relevant for a corrective protocol for HDR brachytherapy boost treatment. The dose delivered to points within the urethra and rectum was measured using TLD in vivo dosimetry in 56 patients. Comparisons between the urethral and rectal measurements and TPS ... | 18,954,914 |
Surface physicochemical analysis of natural Lactococcus lactis strains reveals the existence of hydrophobic and low charged strains with altered adhesive properties. | The cell surface physicochemical properties of 50 Lactococcus lactis strains of different subspecies and isolated from different origins (dairy, vegetal and animal) were examined. Cell surface hydrophobicity and Lewis acid-base properties were evaluated by affinity measurements to solvents in a partitioning test, while... | 18,954,916 |
Detoxification and repair process of ozone injury: from O3 uptake to gene expression adjustment. | Plants react to O(3) threat by setting up a variety of defensive strategies involving the co-ordinated modulation of stress perception, signalling and metabolic responses. Although stomata largely controls O(3) uptake, differences in O(3) tolerance cannot always be ascribed to changes in stomatal conductance but cell p... | 18,954,925 |
Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia. | To determine the predictive power of the out-of-hospital cardiac arrest (OHCA) score and serum neuron-specific enolase (NSE) in patients resuscitated from ventricular fibrillation treated with therapeutic hypothermia (TH) and glucose control. An analysis of prospectively collected data of 90 TH patients. Serum NSE was ... | 18,954,930 |
Percutaneous access for endovascular abdominal aortic aneurysm repair: can selection criteria be expanded? | Previous reports suggest that percutaneous access for endovascular abdominal aortic aneurysm repair (P-EVAR) is as safe as open access (O-EVAR) in patients with favorable femoral anatomy. Severe femoral artery calcification and obesity have been considered relative contraindications to P-EVAR, but these criteria have n... | 18,954,964 |
Impact of total retrieved lymph nodes on staging and survival of patients with gastric cancer invading the subserosa. | To investigate the impact of total retrieved lymph nodes (tLNs) on staging and survival in patients with pT2b gastric cancer according to the nodal status. Clinicopathological characteristics and prognostic outcomes of 392 patients with pT2b gastric cancer between 1980 and 2005 were retrospectively investigated based o... | 18,954,972 |
The effect of stratification and seasonal variability on the profile of an anaerobic swine waste treatment lagoon. | In this study, the characterization of an anaerobic swine waste treatment lagoon from a farrowing operation (approximately 2000 sows) was carried out to examine the dynamics of the system due to stratification and seasonal variability. Swine waste samples were taken at different depths with a pulley system equipped wit... | 18,954,977 |
Alpha-mercaptoketone based histone deacetylase inhibitors. | In an effort to discover novel non-hydroxamic acid histone deacetylase (HDAC) inhibitors, a novel alpha-mercaptoketone was identified in a high-throughput screen. Lead optimization of the screening hit, led to a number of potent HDAC inhibitors. In particular, alpha-mercaptoketone 19y (KD5150) exhibited nanomolar in vi... | 18,954,984 |
Spinal epidural lipomatosis--a brief review. | Spinal epidural lipomatosis (SEL) is a rare disorder characterized by overgrowth of fat in the extradural space, causing compression of the neural elements. It is frequently associated with the administration of exogenous steroids or elevation of endogenous steroids. We present two patients, both with epidural lipamoto... | 18,954,986 |
Varus-valgus laxity correlates with pain in osteoarthritis of the knee. | Pain during osteoarthritis (OA) of the knee does not necessarily correlate with the severity of the radiographic grade, and the mechanism of pain has not been completely clarified. The purpose of this study was to evaluate risk factors for pain in the knee OA using epidemiologic analyses. We evaluated 518 out of 4183 p... | 18,954,990 |
Efficient synthesis and biological evaluation of two modafinil analogues. | Non classical bioisosters of modafinil featuring interesting biological profile have been easily produced through replacement of the sulfoxide function with a carbonyl group and modification of the carboxylic acid amide functionality. | 18,954,992 |
DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes. | In this study, we were interested in the overall methylation level in aged and degenerated cartilage. Also, we looked at one gene which might be involved in the re-initiation of replicative activity in osteoarthritis (OA) chondrocytes, p21(WAF1/CIP1). p21(WAF1/CIP1) was previously suggested to be down-regulated in OA c... | 18,954,998 |
A dosimetric comparison of MammoSite and ClearPath high-dose-rate breast brachytherapy devices. | A new form of partial breast irradiation (PBI), ClearPath (CP) breast brachytherapy, has been introduced. We present our results of a dosimetric comparison of MammoSite (MS) and CP PBI. The dimensions of the CP device were reconstructed onto the MS planning CT scans for 15 previously treated patients. The mean %V(100),... | 18,955,018 |
Hybrid synapse formation between spinal motoneurons and superior cervical ganglion neurons in vitro: a study of the functional reconstruction of visceral organs. | Spinal motoneurons (SMNs) were co-cultured with labeled superior cervical ganglion neurons (SCGNs) in complete medium on coverslips prepared by the microisland technique. "Hybrid" synapses formation between SMNs and SCGNs was examined by double immunostaining, reverse transcription-polymerase chain reaction (RT-PCR), a... | 18,955,021 |
Deep membrane insertion of prion protein upon reduction of disulfide bond. | The membrane may play a role in the pathogenesis of the prion protein (PrP). Cytoplasmic expression of PrP causes the conversion of PrP to a self-perpetuating PrP(Sc)-like conformation and the interaction of polypeptide chain with the hydrophobic core of the membrane is believed to be closely correlated with neurodegen... | 18,955,027 |
Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1. | To characterize the regulatory mechanism of the interferon regulatory factor (IRF) family, we performed yeast two-hybrid screening with IRF-2 and isolated the small ubiquitin-related modifier (SUMO)-conjugating enzyme Ubc9, which also interacts with other IRF family members IRF-1 and ICSBP. Subsequent assays indicated ... | 18,955,028 |
Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha. | Although PDZK1 is a well-known adaptor protein, the mechanisms for its role in transcriptional regulation are largely unknown. The peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor that plays an important role in the regulation of lipid homeostasis. Previously, we e... | 18,955,051 |
Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect. | Sulfur mustard (HD, SM), is a chemical warfare agent that within hours causes extensive blistering at the dermal-epidermal junction of skin. To better understand the progression of SM-induced blistering, gene expression profiling for mouse skin was performed after a single high dose of SM exposure. Punch biopsies of mo... | 18,955,075 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.