title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population. | Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males... | 18,957,718 |
Ergonomics for children: an educational program for elementary school. | Studies indicate that musculoskeletal discomfort and back pain problems are evident not only in adults, but also in children [11,13]. We believe that educating towards a balanced-posture, body-function and movement patterns, as well as their ergonomic implications, can minimize and even prevent these problems. Such an ... | 18,957,743 |
Behaviors of physiologically active bacteria in water environment and chlorine disinfection. | Direct microscopic methods using several fluorescent staining were applied to estimate the proportion of physiologically active bacteria in the water environment and evaluate the efficacy of disinfection with chlorine. 4',6-diamidino-2-phenylindole (DAPI) was used to determine total bacterial numbers, and 5-cyano-2,3-d... | 18,957,745 |
Codigestion of manure and industrial organic waste at centralized biogas plants: process imbalances and limitations. | The present study focuses on process imbalances in Danish centralized biogas plants treating manure in combination with industrial waste. Collection of process data from various full-scale plants along with a number of interviews showed that imbalances occur frequently. High concentrations of ammonia or long chain fatt... | 18,957,768 |
Measuring the effectiveness of performance-based training. | This article describes a statistical analysis of small water systems' turbidity data within the framework of a logic model for the USEPA's Performance-Based Training (PBT) program. The logic model shows the theoretical linkages between optimization training for small system operators; operator application of optimizati... | 18,957,784 |
Mechanical strain increases expression of type XII collagen in murine osteoblastic MC3T3-E1 cells. | In adult mouse, the mRNA corresponding to the alpha1 chain of type XII collagen (alpha 1(XII)) is predominantly detected in the bone. Additionally, murine osteoblastic cells, MC3T3-E1, increased the mRNA level of alpha 1(XII) response to the mechanical strain in the stretch culture system. Cyclic stretch stress resulte... | 18,957,791 |
The metabolic syndrome as a concept of adipose tissue disease. | The metabolic syndrome is a constellation of interrelated metabolic risk factors that appear to directly promote the development of diabetes and cardiovascular disease. However, in 2005, the American Diabetes Association and the European Association for the Study of Diabetes jointly stated that no existing definition o... | 18,957,797 |
Monosynaptic excitatory connection from the rostral ventrolateral medulla to sympathetic preganglionic neurons revealed by simultaneous recordings. | To directly investigate whether a monosynaptic connection exists between neurons in the rostral ventrolateral medulla (RVLM) and sympathetic preganglionic neurons (SPNs), we used simultaneous extracellular recordings of RVLM neurons and whole-cell patch-clamp recordings of SPNs at the Th2 level and analyzed them by spi... | 18,957,816 |
Dose-response relationship for induction of ovarian tumors in mice irradiated during prenatal, early postnatal and elder periods. | Female B6C3F1 mice were irradiated at day 17 prenatal period, day 0, 7, 35, 105, 240, 365 and 550 postnatal period with doses of 0.10 to 5.70 Gy gamma rays from (137)Cs. All mice were allowed to live through their entire life spans under a specific-pathogen free condition. The excess relative risk for prevalence at the... | 18,957,829 |
[Relationships of positive and negative affectivity to sleep quality in Japanese civil servants: 3-year follow-up study]. | We conducted this longitudinal study to evaluate the relationships of positive and negative affectivity (Affect Balance Scale) to sleep quality among civil servants. For this study we evaluated 827 civil servants of T city in Toyama prefecture in the springs of 2001 (Baseline) and 2004 with complete information in both... | 18,957,834 |
Effect of insulin-like growth factor-I gene therapy on the somatotropic axis in experimental prolactinomas. | Insulin-like growth factor-I (IGF-I) provides a physiologic feedback effect within the somatotropic axis. Gene therapy was implemented in young female Sprague-Dawley rats which received 2 pituitary stereotaxic injections of a control recombinant adenoviral vector expressing green fluorescent protein (RAd-GFP) or IGF-I ... | 18,957,836 |
Time delay between onset of symptoms and diagnosis in pulmonary thromboembolism. | Although pulmonary thromboembolism is usually considered as an acute illness, delayed presentations are fairly common. The purpose of this study was to investigate delays to presentation/diagnosis and their likely correlation with patients' clinical and radiographic findings in pulmonary thromboembolism. All cases of p... | 18,957,839 |
Protein restriction during pregnancy induces hypertension and impairs endothelium-dependent vascular function in adult female offspring. | Intrauterine undernutrition plays a role in the development of adult hypertension. Most studies are done in male offspring to delineate the mechanisms whereby blood pressure may be raised; however, the vascular mechanisms involved in female offspring are unclear. Female offspring of pregnant Sprague-Dawley rats fed eit... | 18,957,856 |
Metagenomics for mining new genetic resources of microbial communities. | Recent progress has revealed that the capture of genetic resources of complex microbial communities in metagenome libraries allows the discovery of a richness of new enzymatic diversity that had not previously been imagined. Activity-based screening of such libraries has demonstrated that this new diversity is not simp... | 18,957,866 |
Implantation of dedifferentiated fat cells ameliorates habu snake venom-induced chronic renal dysfunction in tenascin-C-deficient mice. | We established dedifferentiated fat (DFAT) cells from mature adipocytes that differentiate to multiple lineages and have characteristics similar to those of mesenchymal stem cells. In this study, we evaluated the effect of implantation of DFAT cells on habu snake venom (HSV)-induced renal dysfunction in tenascin-C knoc... | 18,957,871 |
New approaches to target microsomal triglyceride transfer protein. | Microsomal triglyceride transfer protein (MTP), a chaperone for the biosynthesis of apolipoprotein B lipoproteins and CD1d, is a therapeutic candidate to decrease plasma lipids and to diminish inflammation. MTP inhibition increases plasma transaminases and tissue lipids, and therefore new approaches are needed to avoid... | 18,957,879 |
The trials and tribulations of the treatment of nonalcoholic fatty-liver disease. | To review published clinical trials, with a focus on those of randomized design, of the management of nonalcoholic fatty-liver disease (NAFLD), an increasing complication of the obesity epidemic. There is increasing recognition that cardiovascular risk issues are associated with NAFLD. Clinical trials of management of ... | 18,957,882 |
Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitis. | Antimicrobial peptides are intrinsic to the innate immune system in many organ systems, but little is known about their expression in the central nervous system. We examined cerebrospinal fluid (CSF) and serum from patients with active bacterial meningitis to assess antimicrobial peptides and possible bactericidal prop... | 18,957,897 |
[The physician-patient relationship in chronic disease management]. | The relationship between patients and clinicians is a key element in the management of chronic diseases. With the objective of a more efficient communication, the clinician should know his own personality but also the patient personality. The organisation of the consultation, of the waiting room and of the secretary ha... | 18,957,911 |
[News in trabeculoplasty]. | The main objection to argon laser trabeculoplasty is collateral tissular injury, requiring hazardous repeated sessions if tonometric efficacy decreases. Selective trabeculoplasty could allow reliably effective iterative sessions because it is relatively harmless to tissues. Two other physical methods are on the market,... | 18,957,920 |
[Tolerance to fixed combinations]. | Four classes of drugs are mainly used for glaucoma medical therapy: beta-blockers, prostaglandin analogs, alpha-2 agonists, and carbonic anhydrase inhibitors. Clinicians can prescribe fixed combinations that associate two drugs from two different classes that have been available for a long time. Tolerance of fixed comb... | 18,957,921 |
SNP analyses of postprandial responses in (an)orexigenic hormones and feelings of hunger reveal long-term physiological adaptations to facilitate homeostasis. | The postprandial responses in (an)orexigenic hormones and feelings of hunger are characterized by large inter-individual differences. Food intake regulation was shown earlier to be partly under genetic control. This study aimed to determine whether the postprandial responses in (an)orexigenic hormones and parameters of... | 18,957,934 |
A large-scale functional approach to uncover human genes and pathways in Drosophila. | We demonstrate the feasibility of performing a systematic screen for human gene functions in Drosophila by assaying for their ability to induce overexpression phenotypes. Over 1 500 transgenic fly lines corresponding to 236 human genes have been established. In all, 51 lines are capable of eliciting a phenotype suggest... | 18,957,936 |
Genome-wide association scan for five major dimensions of personality. | Personality traits are summarized by five broad dimensions with pervasive influences on major life outcomes, strong links to psychiatric disorders and clear heritable components. To identify genetic variants associated with each of the five dimensions of personality we performed a genome-wide association (GWA) scan of ... | 18,957,941 |
The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice. | Neuroinflammation plays a role in the progression of several neurodegenerative disorders. We used a lipopolysaccharide (LPS) model of neuroinflammation to characterize the gene expression changes underlying the inflammatory and behavioral effects of neuroinflammation. A single intracerebroventricular injection of LPS (... | 18,957,951 |
International standards to document remaining autonomic function after spinal cord injury. | Experts opinions consensus. To develop a common strategy to document remaining autonomic neurologic function following spinal cord injury (SCI). The impact of a specific SCI on a person's neurologic function is generally described through use of the International Standards for the Neurological Classification of SCI. Th... | 18,957,962 |
Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM. | We have previously demonstrated safety of G207, a doubly mutated (deletion of both gamma(1)34.5 loci, insertional inactivation of U(L)39) herpes simplex virus (HSV) for patients stereotactically inoculated in enhancing portions of recurrent malignant gliomas. We have now determined safety of two inoculations of G207, b... | 18,957,964 |
A new potent secondary amphipathic cell-penetrating peptide for siRNA delivery into mammalian cells. | RNA interference constitutes a powerful tool for biological studies, but has also become one of the most challenging therapeutic strategies. However, small interfering RNA (siRNA)-based strategies suffer from their poor delivery and biodistribution. Cell-penetrating peptides (CPPs) have been shown to improve the intrac... | 18,957,965 |
Consumption of 'extra' foods by Australian adults: types, quantities and contribution to energy and nutrient intakes. | To identify the types and quantities of 'extra' foods, or energy-dense, nutrient-poor foods, consumed by Australian adults, and assess their contribution to total energy and nutrient intakes. We used 24-h recall data from 10 851 adults, aged 19 years and over, who participated in the nationally representative 1995 Nati... | 18,957,970 |
Effect of the glycemic index of carbohydrates on day-long (10 h) profiles of plasma glucose, insulin, cholecystokinin and ghrelin. | Low glycemic index (GI) carbohydrates have been linked to increased satiety. The drive to eat may be mediated by postprandial changes in glucose, insulin and gut peptides. To investigate the effect of a low and a high GI diet on day-long (10 h) blood concentrations of glucose, insulin, cholecystokinin (CCK) and ghrelin... | 18,957,972 |
Transient widespread blood-brain barrier alterations after cerebral photothrombosis as revealed by gadofluorine M-enhanced magnetic resonance imaging. | Magnetic resonance imaging (MRI) is a powerful tool to assess brain lesions, but currently available contrast agents are limited in the assessment of cellular and functional alterations. By use of the novel MRI contrast agent gadofluorine M (Gf) we report on imaging of transient and widespread changes of blood-brain ba... | 18,957,988 |
GABA synapses mediate neuroprotection after ischemic and epsilonPKC preconditioning in rat hippocampal slice cultures. | Delayed neuroprotection against ischemic challenges is conferred by both ischemic preconditioning (IPC) and preconditioning by activation of the epsilon-isoform of protein kinase C (epsilonPKC-PC). In vivo, ischemic preconditioning enhances GABA release and ameliorates glutamate release during lethal cerebral ischemia.... | 18,957,990 |
Children's inhalation exposure to methamidophos from sprayed potato fields in Washington State: exploring the use of probabilistic modeling of meteorological data in exposure assessment. | We examined the significance of meteorology and postspray volatilization of methamidophos (an organophosphorus insecticide) in assessing potential inhalation risk to children in an agricultural community. We combined fluxes from sources and dispersion modeling with a range of possible local meteorology to create output... | 18,957,992 |
Multipolar analysis of second-harmonic radiation from gold nanoparticles. | We present a multipolar tensor analysis of second-harmonic radiation from arrays of noncentrosymmetric L-shaped gold nanoparticles. Our approach is based on the fundamental differences in the radiative properties of electric dipoles and higher multipoles, which give rise to differences in the nonlinear response tensors... | 18,958,000 |
Exploring the limits of single emitter detection in fluorescence and extinction. | We present an experimental comparison and a theoretical analysis of the signal-to-noise ratios in fluorescence and extinction spectroscopy of a single emitter. We show that because of its homodyne nature the extinction measurements can be advantageous if the emitter is weakly excited. Furthermore, we discuss the potent... | 18,958,019 |
Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate, part I: simulation. | We investigate the feasibility of trans-rectal optical tomography of the prostate using an endo-rectal near-infrared (NIR) applicator that is to be integrated with a trans-rectal ultrasound (TRUS) probe. Integration with TRUS ensures accurate endo-rectal positioning of the NIR applicator and the utility of using TRUS s... | 18,958,030 |
Advancing multifocal nonlinear microscopy: development and application of a novel multibeam Yb:KGd(WO4)2 oscillator. | We present a novel Yb:KGd(WO(4))(2) oscillator design that generates six beams of temporally delayed, 253 fs, 11 nJ pulses. This allows multifocal nonlinear microscopy to be performed without the need for complicated optical multiplexers. We demonstrate our design with twelve simultaneously acquired two-photon, second-... | 18,958,037 |
A comparative study of noisy signal evolution in 2R all-optical regenerators with normal and anomalous average dispersions using an accelerated Multicanonical Monte Carlo method. | In [Opt. Express 15, 10061 (2007)] we proposed a new regime of multichannel all-optical regeneration that required anomalous average dispersion. This regime is superior to the previously studied normal-dispersion regime when signal distortions are deterministic in their temporal shape. However, there was a concern that... | 18,958,052 |
Two-photon-induced excited-state nonlinearities. | We report a theoretical investigation of laser-pulse-duration dependence of excited-state nonlinearities induced by two-photon absorption (2PA). We investigate the spatiotemporal characteristics of the transmitted pulses caused by 2PA-induced excited-state absorption, which strongly depends on laser pulse duration. By ... | 18,958,055 |
Application of structured illumination for multiple scattering suppression in planar laser imaging of dense sprays. | A novel approach to reduce the multiple light scattering contribution in planar laser images of atomizing sprays is reported. This new technique, named Structured Laser Illumination Planar Imaging (SLIPI), has been demonstrated in the dense region of a hollow-cone water spray generated in ambient air at 50 bars injecti... | 18,958,069 |
An analysis of heterodyne signals in apertureless scanning near-field optical microscopy. | This study constructs interference-based model of the apertureless scanning near-field optical microscopy (A-SNOM) heterodyne detection signal which takes account of both the tip enhancement phenomena and the tip reflective background electric field. The analytical model not only provides a meaningful explanation of th... | 18,958,078 |
All-optical retrieval of the global phase for two-dimensional Fourier-transform spectroscopy. | A combination of spatial interference patterns and spectral interferometry are used to find the global phase for non-collinear two-dimensional Fourier-transform (2DFT) spectra. Results are compared with those using the spectrally resolved transient absorption (STRA) method to find the global phase when excitation is wi... | 18,958,080 |
Photonic crystal with multiple-hole defect for sensor applications. | A photonic crystal defect consisting of several subwavelength holes was investigated as a means to increase the surface area of the defect region without compromising the quality factor of the structure. Finite-difference time-domain calculations were performed to determine the relationships between the size of the mul... | 18,958,096 |
Realtime photoacoustic microscopy of murine cardiovascular dynamics. | Non-invasive visualization of cardiovascular dynamics in small animals is challenging due to their rapid heart-rates. We present a realtime photoacoustic imaging system consisting of a 30-MHz ultrasound array transducer, receive electronics, a high-repetition-rate laser, and a multicore-computer, and demonstrate its ab... | 18,958,134 |
Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivo. | A variety of physiological and pathological factors induce cellular swelling in the brain. Changes in cell volume activate several types of ion channels, which mediate the release of inorganic and organic osmolytes and allow for compensatory cell volume decrease. Volume-regulated anion channels (VRAC) are thought to be... | 18,958,155 |
In vitro identification and characterization of CD133(pos) cancer stem-like cells in anaplastic thyroid carcinoma cell lines. | Recent publications suggest that neoplastic initiation and growth are dependent on a small subset of cells, termed cancer stem cells (CSCs). Anaplastic Thyroid Carcinoma (ATC) is a very aggressive solid tumor with poor prognosis, characterized by high dedifferentiation. The existence of CSCs might account for the heter... | 18,958,156 |
Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products. | While we lack a complete understanding of the molecular mechanisms by which parasites establish and achieve protection from host immune responses, it is accepted that many of these processes are mediated by products, primarily proteins, released from the parasite. Parasitic nematodes occur in different life stages and ... | 18,958,170 |
Coincidence between transcriptome analyses on different microarray platforms using a parametric framework. | A parametric framework for the analysis of transcriptome data is demonstrated to yield coincident results when applied to data acquired using two different microarray platforms. Microarrays are widely employed to acquire transcriptome information, and several platforms of chips are currently in use. However, discrepanc... | 18,958,174 |
Progestin receptor-mediated reduction of anxiety-like behavior in male rats. | It is well known progesterone can have anxiolytic-like effects in animals in a number of different behavioral testing paradigms. Although progesterone is known to influence physiology and behavior by binding to classical intracellular progestin receptors, progesterone's anxiety reducing effects have solely been attribu... | 18,958,180 |
CRF1 receptor activation increases the response of neurons in the basolateral nucleus of the amygdala to afferent stimulation. | The basolateral nucleus (BLA) of the amygdala contributes to the consolidation of memories for emotional or stressful events. The nucleus contains a high density of CRF1 receptors that are activated by corticotropin-releasing factor (CRF). Modulation of the excitability of neurons in the BLA by CRF may regulate the imm... | 18,958,192 |
Response inhibition is linked to emotional devaluation: behavioural and electrophysiological evidence. | To study links between the inhibition of motor responses and emotional evaluation, we combined electrophysiological measures of prefrontal response inhibition with behavioural measures of affective evaluation. Participants first performed a Go-Nogo task in response to Asian and Caucasian faces (with race determining th... | 18,958,213 |
Sequential activation of human oculomotor centers during planning of visually-guided eye movements: a combined fMRI-MEG study. | We used magneto-encephalography (MEG) to measure visually evoked activity in healthy volunteers performing saccadic eye movements to visual targets. The neuromagnetic activity was analyzed from regions of cortical activation identified in separate functional magnetic resonance imaging (fMRI) studies. The latency of vis... | 18,958,215 |
No disillusions in auditory extinction: perceiving a melody comprised of unperceived notes. | The formation of coherent percepts requires grouping together spatio-temporally disparate sensory inputs. Two major questions arise: (1) is awareness necessary for this process; and (2) can non-conscious elements of the sensory input be grouped into a conscious percept? To address this question, we tested two patients ... | 18,958,228 |
Conditioned reinforcement can be mediated by either outcome-specific or general affective representations. | Conditioned reinforcers are Pavlovian cues that support the acquisition and maintenance of new instrumental responses. Responding on the basis of conditioned rather than primary reinforcers is a pervasive part of modern life, yet we have a remarkably limited understanding of what underlying associative information is t... | 18,958,230 |
Cortical activity influences geniculocortical spike efficacy in the macaque monkey. | Thalamocortical communication is a dynamic process influenced by both presynaptic and postsynaptic mechanisms. In this study, we recorded single-unit responses from cortical neurons that received direct input from the lateral geniculate nucleus (LGN) to address the question of whether prior patterns of cortical activit... | 18,958,231 |
Multisensory integration produces an initial response enhancement. | The brain has evolved the ability to integrate information across the senses in order to improve the detection and disambiguation of biologically significant events. This multisensory synthesis of information leads to faster (and more accurate) behavioral responses, yet the underlying neural mechanisms by which these r... | 18,958,232 |
Category-specific responses to faces and objects in primate auditory cortex. | Auditory and visual signals often occur together, and the two sensory channels are known to influence each other to facilitate perception. The neural basis of this integration is not well understood, although other forms of multisensory influences have been shown to occur at surprisingly early stages of processing in c... | 18,958,243 |
Associative and non-associative plasticity in kenyon cells of the honeybee mushroom body. | The insect mushroom bodies are higher-order brain centers and critical for odor learning. We investigated experience dependent plasticity of their intrinsic neurons, the Kenyon cells (KCs). Using calcium imaging, we recorded KC responses and investigated non-associative plasticity by applying repeated odor stimuli. Ass... | 18,958,247 |
Spontaneous coronary artery dissection: current insights and therapy. | Spontaneous coronary artery dissection (SCAD) is a very rare cause of acute coronary syndromes in young otherwise healthy patients with a striking predilection for the female gender. The pathological mechanism has not been fully clarified yet. However, several diseases and conditions have been associated with SCAD, suc... | 18,958,258 |
Heaven can wait - or down to earth in real time: Near-death experience revisited. | Near-death experience (NDE) is an intriguing phenomenon that invites more questions than answers. Hitherto emphasis has been laid on apparent similarities in accounts of NDE to prove a supernatural origin while in fact unique differences besides gross similarities support a neurophysiological explanation. A teleologica... | 18,958,261 |
Acquisition of growth-inhibitory antibodies against blood-stage Plasmodium falciparum. | Antibodies that inhibit the growth of blood-stage Plasmodium falciparum may play an important role in acquired and vaccine-induced immunity in humans. However, the acquisition and activity of these antibodies is not well understood. We tested dialysed serum and purified immunoglobulins from Kenyan children and adults f... | 18,958,278 |
Roadless wilderness area determines forest elephant movements in the Congo Basin. | A dramatic expansion of road building is underway in the Congo Basin fuelled by private enterprise, international aid, and government aspirations. Among the great wilderness areas on earth, the Congo Basin is outstanding for its high biodiversity, particularly mobile megafauna including forest elephants (Loxodonta afri... | 18,958,284 |
Taurine suppresses the spread of cell death in electrically coupled RPE cells. | To determine whether taurine exerts a protective effect on retinal pigment epithelium (RPE) cells exposed to a cytotoxic agent, cytochrome C (cyC), shown previously to induce apoptosis and produce cell death in electrically coupled neighboring cells. Monolayer cultures of confluent human RPE (ARPE-19) cells, which expr... | 18,958,305 |
A review of systematic reviews on pain interventions in hospitalized infants. | Hospitalized infants undergo multiple, repeated painful procedures. Despite continued efforts to prevent procedural pain and improve pain management, clinical guidelines and standards frequently do not reflect the highest quality evidence from systematic reviews. To critically appraise all systematic reviews on the eff... | 18,958,314 |
Photoreduction of 2-methyl-1-nitro-9,10-anthraquinone in the presence of 1-phenylethanol. | The photoreactions of 1-nitro-9,10-anthraquinone (N1) and 2-methyl-1-nitro-9,10-anthraquinone (N2) were studied in benzene and acetonitrile in the presence of 1-phenylethanol. For N2, a short-lived 10 ns transient observed upon flash photolysis is attributed to a triplet state, which can be intercepted by 1-phenylethan... | 18,958,321 |
Chlorochromate ion as a catalyst for the photodegradation of chloroform by visible light. | Exposure of solutions of tetrabutylammonium chlorochromate in chloroform to UV or blue light causes decomposition of the chloroform and the buildup of HCl and peroxides in solution. The CrO(3)Cl(-) is converted during irradiation to CrO(2)Cl(2), which forms a suspension in the chloroform, and then to CrOCl(4)(-). CrO(2... | 18,958,324 |
Characterization of new fluorescent labels for ultra-high resolution microscopy. | Photo-induced switching of dyes into dark, long-lived states, such as a triplet state, has recently gained increasing interest, as a means to achieve ultra-high optical resolution. Additionally, these long lived states are often highly environment-sensitive and their photodynamics can thus offer additional independent ... | 18,958,325 |
Radical cage effects: a method for measuring recombination efficiencies of secondary geminate radical cage pairs using pump-probe transient absorption methods. | A method is reported for measuring the recombination efficiency of secondary geminate radical cage pairs. The procedure involves measuring the recombination efficiency for primary geminate recombination (F(c1)) using pump-probe laser methods and measuring the "apparent" (or net) recombination efficiency (F(cP)) for all... | 18,958,326 |
[Backpain and haemophilia]. | A literature research for back pain in hemophilia (1990-2007) revealed only five papers! They all had lumbar or sciatic pain due to hematoma. All symptoms responded to factor VIII replacement. A similar research for a normal population showed hundreds of papers with a lifetime prevalence of 80% for back pain. A survey ... | 18,958,339 |
Enhanced thrombin generation in plasma of severe thrombocytopenic patients due to rFVIIa. | RFVIIa-enhanced thrombin generation has been shown to be dependent on platelets. In previous work we have shown that addition of monocytes and rFVIIa to microparticle free plasma causes a distinct thrombin generation. The aim of our study has been to examine whether there is enough surface provided by microparticles in... | 18,958,344 |
Sperm nuclear histone H2B: correlation with sperm DNA denaturation and DNA stainability. | To examine the relationship between sperm DNA damage and sperm nuclear histone (H2B) staining. We evaluated sperm samples from 14 consecutive asthenoteratozoospermic infertile men and six consecutive fertile controls. Sperm nuclear histone (H2B) staining and sperm chromatin integrity (assessed by sperm chromatin struct... | 18,958,350 |
Postnatal roles of glial cell line-derived neurotrophic factor family members in nociceptors plasticity. | The neurotrophin and glial cell line-derived neurotrophic factor (GDNF) family of growth factors have been extensively studied because of their proven ability to regulate development of the peripheral nervous system. The neurotrophin family, which includes nerve growth factor (NGF), NT-3, NT4/5 and BDNF, is also known ... | 18,958,362 |
Australian pelvic floor questionnaire: a validated interviewer-administered pelvic floor questionnaire for routine clinic and research. | The aim of this study was to design and validate an interviewer-administered pelvic floor questionnaire that integrates bladder, bowel and sexual function, pelvic organ prolapse, severity, bothersomeness and condition-specific quality of life. Validation testing of the questionnaire was performed using data from 106 ur... | 18,958,382 |
Typical trigeminal neuralgia associated with brainstem white matter lesions on MRI in patients without criteria of multiple sclerosis. | Although compression of the trigeminal nerve by a vascular loop is thought to be the most common cause of trigeminal neuralgia (TN), other aetiologies, such as multiple sclerosis or brainstem infarction may be associated with this disorder. MRI may detect lesions different from vascular loop compression of the trigemin... | 18,958,387 |
Intractable hiccups as a presenting symptom of Chiari I malformation. | Hiccups as the only presenting symptom in neurosurgical practice is uncommon. We report a case of a 22-year-old man who was evaluated for a 9-month history of intractable hiccups. He was diagnosed with a case of Chiari malformation type I. Surgical decompression improved the symptoms of the patient. The cause and patho... | 18,958,392 |
Interdisciplinarity and participatory approaches to environmental health: reflections from a workshop on social, economic and behavioural factors in the genesis and health impact of environmental hazards. | This paper reviews a workshop discussion postulated on the notion that social, economic and behavioural factors are responsible for the creation of environmental hazards and benefits that, in turn, can affect human health, with concomitant effects on future social well-being. The workshop case study centred on environm... | 18,958,398 |
Return to work after injury: a review of evidence regarding expectations and injury perceptions, and their influence on outcome. | Work disability after injury is a complex problem, and there remains a lack of clarity about what factors are most influential on whether or not someone will experience difficulty returning to work. Increasingly, expectations and injury perceptions are being explored as potential factors in work disability, because of ... | 18,958,407 |
On-line characterization of physiological state in poly(beta-hydroxybutyrate) production by Wautersia eutropha. | Culture fluorescence measurement technique has the potential for on-line characterization of metabolic status of fermentation processes. Many fluorophores present inside the living cells such as NADH + H+, tryptophan, pyridoxine, and riboflavin fluoresce at specific excitation and emission wavelength combinations. Sinc... | 18,958,410 |
APE1/Ref-1 promotes the effect of angiotensin II on Ca2+ -activated K+ channel in human endothelial cells via suppression of NADPH oxidase. | The effects of angiotensin II (Ang II) on whole-cell large conductance Ca(2+)-activated K(+) (BK(Ca)) currents was investigated in control and Apurinic/apyrimidinic endonuclease1/redox factor 1 (APE1/Ref-1)-overexpressing human umbilical vein endothelial cells (HUVECs). Ang II blocked the BK(Ca) current in a dose-depen... | 18,958,420 |
A new ferulic acid ester and other constituents from Dracocephalum peregrinum. | A new ferulic acid ester, 1'-methyl-2'-hydroxyethyl ferulate (1), together with methylcaffeate (2), 4-hydroxy cinnamic acid (3), ferulic acid (4), caffeic acid (5), diosmetin (6), luteolin (7), 5,3',4'-trihydroxy-3,7-dimethoxyflavone (8), eriodictyol (9), kaempferol (10), quercetin (11), acacetin-7-O-glcopyranoside (12... | 18,958,424 |
In vitro and in vivo evaluation of ranitidine hydrochloride loaded hollow microspheres in rabbits. | The objective of this investigation was to develop the hollow microspheres as a new dosage form of floating drug delivery systems with prolonged stomach retention time. Hollow microspheres containing ranitidine hydrochloride (RH) were prepared by a novel solvent diffusion-evaporation method using ethyl cellulose (EC) d... | 18,958,430 |
[Gender differences in psychopharmacology]. | At least half of all patients with psychiatric disorders are female. Depressive disorders occur twice as often in women than in men. Despite the need for a gender-specific approach in treating psychiatric disorders, little is known about gender issues in psychopharmacology. It has been recognized that women respond bet... | 18,958,437 |
[A 47-year-old patient with longstanding nicotine abuse, increasing dyspnea on exertion and lower and peripheral lung predominant ground-glass opacities]. | The causal relationship between cigarette smoking and a number of interstitial lung diseases continues to evolve. These "smoking-related interstitial lung diseases" (SR-ILD) are a heterogeneous group of entities which have overlapping imaging findings and which can coexist. The presented case of a patient with smoking ... | 18,958,443 |
Renal injury at first presentation as a predictor for poor outcome in severe paracetamol poisoning referred to a liver transplant unit. | Paracetamol poisoning remains a leading cause of morbidity and mortality. Identifying indices of poor prognosis at first presentation is key to both improving clinical care and determining targets for intervention. Renal failure is a feature of severe paracetamol poisoning. The aim of this study was to investigate the ... | 18,958,458 |
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. | Astroblastoma is a very rare primary glial tumor occurring in children and young adults that is almost exclusively supratentorial in location. We report an extremely unusual presentation of a densely calcified posterior fossa astroblastoma with disseminated spinal and supratentorial metastasis. The mass exhibited neopl... | 18,958,463 |
Prognostic significance of p16/cdkn2a loss in pleural malignant mesotheliomas. | Homozygous deletion of p16/CDKN2A is the most common genetic abnormality in malignant mesotheliomas. The aim of this study was to determine prognostic significance of p16/CDKN2A loss in malignant pleural mesotheliomas (MPM) as defined by immunohistochemistry and fluorescence in situ hybridization (FISH). High-density t... | 18,958,493 |
Structure-function analysis of the barley genome: the gene-rich region of chromosome 2HL. | A major gene-rich region on the end of the long arm of Triticeae group 2 chromosomes exhibits high recombination frequencies, making it an attractive region for positional cloning. Traits known to be controlled by this region include chasmogamy/cleistogamy, frost tolerance at flowering, grain yield, head architecture, ... | 18,958,509 |
The change in surgical practice from subtotal to near-total or total thyroidectomy in the treatment of patients with benign multinodular goiter. | Although total thyroidectomy is the procedure of choice in patients with thyroid carcinoma, this surgical approach has emerged as a surgical option to treat patients with benign multinodular goiter (BMNG), especially in endemically iodine-deficient regions. The aim of this study was to review our experience with patien... | 18,958,517 |
Total parathyroidectomy without autotransplantation for secondary hyperparathyroidism. | To treat secondary hyperparathyroidism with subtotal parathyroidectomy or total parathyroidectomy with autotransplantation might cause the disease to recur because of growth of the parathyroid remnant or the autografts. The aim of the present study was to determinate an alternative surgical treatment for secondary hype... | 18,958,522 |
Adjuvant postoperative radiotherapy to the cervical lymph nodes in cutaneous melanoma: is there any benefit for high-risk patients? | The use of adjuvant radiotherapy after lymph node dissection for metastatic melanoma remains controversial. This study examined the effectiveness of adjuvant radiotherapy in controlling regional disease in high-risk patients. A total of 716 patients were identified from a large prospective database who underwent cervic... | 18,958,539 |
Abdominal aortic aneurysm surgery for octogenarians. | To define the indications for abdominal aortic aneurysm (AAA) surgery in octogenarians. We reviewed septuagenarians and octogenarians with a nonspecific AAA diagnosed at our hospital between January, 1990 and June, 2006. Among a total 628 patients seen, 306 were in their 70s (group A) and 108 were in their 80s or older... | 18,958,558 |
Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine. | Reactive oxygen species (ROS) and reactive nitrogen species (RNS), generated during tissue reperfusion, are characteristic of ischemia/reperfusion (I/R) injury. We conducted this study to evaluate the protective effect of alpha-lipoic acid (alpha-LA) and ebselen against intestinal I/R injury. Forty Sprague-Dawley rats ... | 18,958,562 |
Annular pancreas causing localized recurrent pancreatitis in a child: report of a case. | Annular pancreas is a rare congenital anomaly. We report a case of relapsing acute pancreatitis localized in the annulus of an annular pancreas in a young child. A 6-year-old boy complained of abdominal pain and we made a diagnosis of acute pancreatitis based on blood biochemistry results. Over the subsequent 12 months... | 18,958,567 |
Treatment of a citrin-deficient patient at the early stage of adult-onset type II citrullinaemia with arginine and sodium pyruvate. | Citrin deficiency is a common congenital metabolic defect not only in East Asian populations but also in other populations around the world. It has been shown that although liver transplantation is ultimately required in many patients to prevent neurological decompensation associated with hyperammonaemia, arginine is e... | 18,958,581 |
Comparative responsiveness and minimal change for the Oxford Elbow Score following surgery. | To assess the responsiveness and minimal change for the Oxford Elbow Score (OES) using anchor- and distribution-based approaches. A prospective observational study of 104 patients undergoing elbow surgery at a specialist orthopaedic hospital was carried out. Patients completed the OES and the Disabilities of the Arm, S... | 18,958,582 |
Haemato-biochemical responses and induction of HSP70 to dietary phosphorus in Catla catla (Hamilton) fingerlings. | A feeding trial of 120 days was conducted to study the effect of graded levels of dietary phosphorus on haematology, serum protein concentrations and HSP70 expression in fingerlings of the Indian major carp, Catla (Catla catla). Eight isonitrogenous and isoenergetic purified diets were formulated to contain graded leve... | 18,958,586 |
Cypermethrin and lambda-cyhalothrin induced alterations in nucleic acids and protein contents in a freshwater fish, Channa punctatus. | In this study, a freshwater fish Channa punctatus was exposed to subacute concentrations of synthetic pyrethroid insecticides (cypermethrin and lambda-cyhalothrin) for 96 h to evaluate their impact on the levels of nucleic acids and protein in its different organs. Significant enhancement in the level of DNA was record... | 18,958,590 |
Functional and stoichiometric analysis of subunit e in bovine heart mitochondrial F(0)F(1)ATP synthase. | The role of the integral inner membrane subunit e in self-association of F(0)F(1)ATP synthase from bovine heart mitochondria was analyzed by in situ limited proteolysis, blue native PAGE/iterative SDS-PAGE, and LC-MS/MS. Selective degradation of subunit e, without disrupting membrane integrity or ATPase capacity, alter... | 18,958,608 |
Poor response to pegylated interferon and ribavirin in older women infected with hepatitis C virus of genotype 1b in high viral loads. | Response to treatment in patients with chronic hepatitis C, with reference to age and gender, has not been examined fully. The influence of gender and age on treatment with pegylated interferon (PEG-IFN) and ribavirin was evaluated in a retrospective study. PEG-IFN and ribavirin were given for 48 weeks to 179 men and 1... | 18,958,621 |
Characterization of Phaseolus vulgaris L. landraces cultivated in central Italy. | Eight Phaseolus vulgaris L. landraces cultivated on farm in marginal areas of Central Italy (Lazio region) were investigated in order to evaluate chemical composition of storage proteins and secondary metabolites fractions. The total protein content showed some differences among landraces; the maximum value was next to... | 18,958,625 |
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