title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Infrequent and low expression of cancer-testis antigens located on the X chromosome in colorectal cancer: implications for immunotherapy in South African populations. | Cancer-testis (CT) antigens are a group of tumor antigens that are expressed in the testis and aberrantly in cancerous tissue but not in somatic tissues. The testis is an immune-privileged site because of the presence of a blood-testis barrier; as a result, CT antigens are considered to be essentially tumor specific an... | 18,956,367 |
Determination of pharmaceuticals in drinking water by CD-modified MEKC: separation optimization using experimental design. | A suite of 12 widely used pharmaceuticals (ibuprofen, diclofenac, naproxen, bezafibrate, gemfibrozil, ofloxacin, norfloxacin, carbamazepine, primidone, sulphamethazine, sulphadimethoxine and sulphamethoxazole) commonly found in environmental waters were separated by highly sulphated CD-modified MEKC (CD-MEKC) with UV d... | 18,956,383 |
On the overestimation of early wall thickening at the carotid bulb by black blood MRI, with implications for coronary and vulnerable plaque imaging. | Black blood MRI is an attractive tool for monitoring normal and pathological wall thickening; however, limited spatial resolutions can conspire with complex vascular geometries to distort the appearance of the wall in ways hitherto unclear. To elucidate this, a thin-walled cylinder model was developed to predict the co... | 18,956,420 |
Identification of rat urinary glycoproteome captured by three lectins using gel and LC-based proteomics. | Many different types of urine proteome studies have been done, but urine glycoprotein studies are insufficient. Therefore, we studied the glycoproteins from rat urine, which could be used to identify biomarkers in an animal model. First, urinary proteins were prepared by using the dialysis and lyophilizing methods from... | 18,956,432 |
Simultaneous determination of seven pesticides in waters using multi-walled carbon nanotube SPE and NACE. | In this work, NACE with UV detection is combined with SPE using multi-walled carbon nanotubes (MWCNT) as stationary phase to determine a group of seven pesticides (pirimicarb, pyrifenox, penconazol, carbendazim, cyromazine, pyrimethanil and cyprodinil) in mineral water samples using ametryn as internal standard. The op... | 18,956,435 |
SPE and large-volume sample stacking in MEKC for determination of doxycycline in biological fluids: comparison of direct injection to SPE-MEKC. | A novel and simple method has been developed for the determination of doxycycline (DOX) in biological fluids. The method is based on SPE, large-volume sample stacking (LVSS) and MEKC with UV-DAD detection. Six SPE cartridges have been used in investigation for sample clean up and pre-concentration (Supelco LC-8, LC-18,... | 18,956,436 |
Dizygotic monochorionic twin pregnancy conceived following intracytoplasmic sperm injection treatment and complicated by twin-twin transfusion syndrome and blood chimerism. | We report a case of a dizygotic monochorionic twin pregnancy preceded by intracytoplasmic sperm injection treatment including assisted hatching. On ultrasound examination at 25 weeks' gestation the twins, which had been assumed to be monochorionic, were found to be of different sexes. Karyotyping and zygocity determina... | 18,956,441 |
Main traumatic events in Europe: PTSD in the European study of the epidemiology of mental disorders survey. | A potentially traumatic event (PTE) contributes to trauma through its frequency, conditional probability of posttraumatic stress disorder (PTSD), and experience of other PTEs. A cross-sectional survey was conducted, enrolling 21,425 adults nationally representative of six European countries. Using the WHO-Composite Int... | 18,956,444 |
Characteristics and management of infectious industrial waste in Taiwan. | Infectious industrial waste management in Taiwan is based on the specific waste production unit. In other countries, management is based simply on whether the producer may lead to infectious disease. Thus, Taiwan has a more detailed classification of infectious waste. The advantage of this classification is that it is ... | 18,956,484 |
Food labeling: health claims; soluble fiber from certain foods and risk of coronary heart disease. Final rule. | The Food and Drug Administration (FDA) is adopting as a final rule, without change, the provisions of the interim final rule (IFR) that amended the regulation authorizing a health claim on soluble fiber from certain foods and risk of coronary heart disease (CHD), to add barley betafiber as an additional eligible source... | 18,956,498 |
Immunohistochemical detection of HIF-1alpha and CAIX in advanced head-and-neck cancer. Prognostic role and correlation with tumor markers and tumor oxygenation parameters. | Tumor hypoxia has an impact on the outcome of cancer patients treated with radiotherapy. The validity of endogenous markers such as hypoxia-inducible factor-1alpha (HIF-1alpha) and carbonic anhydrase isozyme IX (CAIX) to detect therapeutically relevant Levels of hypoxia within tumors is controversially discussed. Furth... | 18,956,515 |
United we stand. Power shifts marginalize physician practices--unless we act and integrate. | How three "seismic events" in Fort Wayne, Ind., pushed a multispecialty group administrator to embrace integration. | 18,956,545 |
Day-night fluctuation of pulse oximetry: an exploratory study in pediatric inpatients. | Pulse oximetry is a simple and non-invasive procedure widely used nowadays in the clinical practice. However, it is unclear if SpO2 values are constant throughout the 24 hours of the day or have periodic fluctuations. In the present study we evaluated if progressive day-night variations of SpO, values occur in children... | 18,956,552 |
[Proof of transovarial transmission of Lymantria dispar nucleopolyhedrovirus (fam. Baculoviridae) with the RAPD-PCR method]. | Transovarial transmission of Lymantria dispar Nucleopolyhedrovirus is shown with the RAPD-PCR method. Genetic markers of virus DNA found with the primer OPA-08 are recommended for diagnostics of Lymantria dispar nucleopolyhedrosis, in particular at the egg stage. Genetic markers of virus DNA found with the use of OPA-0... | 18,956,576 |
Clinical review of 23 patients with tuberculous peritonitis: presenting features and diagnosis. | To better identify which clinical, laboratory, radiological and invasive procedures were most useful in diagnosing tuberculous peritonitis and to assess the methods in order to reach the diagnosis in future cases. Tuberculous peritonitis cases diagnosed between 2000 and 2006 were reviewed retrospectively. Their clinica... | 18,956,596 |
[Safety and efficacy of modified radical lymph nodes dissection in patients with papillary thyroid cancer (PTC) and clinically manifested lymph metastasis]. | Papillary cancer of the thyroid gland is well known as lymphotropic type. In more than 50 percent of cases it metastized in regional lymph nodes. The extent of surgical exploration remains controversial. The aim of our retrospective study is to evaluate safety and efficacy of modified radical lymph node dissection (MRN... | 18,956,604 |
[Surgical treatment of patients with therapy-resistant obsessive-compulsive disorder. Review]. | In spite of adequate pharmaco- and psychotherapy, only 60-80 percent of the patients with obsessive compulsive disorder (OCD) respond to treatment and the symptoms of OCD will persist in 20-40 percent of the cases. These patients are considered therapy resistant. Neurosurgical procedures may bring a breakthrough for pa... | 18,956,611 |
[Exercise addiction: a literature review]. | Exercise in appropriate quantity and of proper quality contributes significantly to the preserve our health. On the contrary, excessive exercise may be harmful to health. The term 'exercise addiction' has been gaining increasing recognition to describe the latter phenomenon. The exact definition of exercise addiction a... | 18,956,613 |
[Central and peripheral mechanisms in antinociception: current and future perspectives]. | As it is well known opioids are the most powerful drugs used for acute and chronic pain, although, their several serious side effects, such as respiratory depression, mental clouding, constipation, and tolerance dependence producing capacity, as well as large interpatient variability in responses limit their safe every... | 18,956,616 |
[Assessment of gestures and their psychiatric relevance]. | Analyzing and investigating non-verbal behavior and gestures has been receiving much attention since the last century. Thanks to the pioneer work of Ekman and Friesen we have a number of descriptive-analytic, categorizing and semantic content related scales and scoring systems. Generation of gestures, the integrative s... | 18,956,625 |
[Relationship between Helicobacter pylori infection and expression of connexin (Cx) 32 and Cx43 genes in gastric cancer and gastric precancerous lesions]. | To investigate the expression of connexin (Cx)32 and Cx43 genes in gastric cancer and precancerous lesion, and to investigate the relation between the changes of expression of Cx32 and Cx43 genes and Helicobacter pylori (Hp) infection. Gastroscopy and biopsy of gastric mucosa were conducted on 33 patients with chronic ... | 18,956,631 |
[Expression and significance of glypican-3 in colorectal cancer]. | To investigate the expression and significance of Glypican-3 in colorectal cancer. Immunohistochemistry was used to detect the expression of Glypican-3 in 200 specimens of colorectal cancer and adjacent non-cancerous tissues resected during operation. Glypican-3 immunoreactivity was recognized in both the cytoplasm and... | 18,956,635 |
[Study on the comparison of high risk behaviors related to AIDS among different status of income in men who have had sex with men]. | To explore the risk sexual behaviors related to AIDS among different status of income among men who have had sex with men and to provide relevant interventions for AIDS control and prevention. Study objectives were recruited through target sampling and anonymous questionnaires were adopted. Men's sexual behaviors were ... | 18,956,671 |
[Study on the indeterminate results of characterization and verification of HIV antibody from Western blot test]. | To study the serological characterization of indeterminate Western blot (WB) results of HIV antibody and to find a new way to verify the HIV antibody indeterminate results and provide references for editing "National Guideline for Detection of HIV/AIDS". All of the 42 subjects who were confirmed as indeterminate HIV an... | 18,956,682 |
[Clinical characteristics and prognostic factors of synchronous gastric carcinoma associated with esophageal carcinoma]. | To investigate the clinical characteristics and prognostic factors of synchronous gastric adenocarcinoma associated with squamous carcinoma of esophagus (SGCEC). From June 1979 to April 2005, 44 patients with SGCEC were treated and the data were retrospectively reviewed. There were 34 male and 10 female. The median age... | 18,956,720 |
[Clinical research about balloon dilation before incision for patients with ureteric stricture]. | To study the use about balloon dilatation before incision for the patients with ureteric stricture. Sixteen patients with ureteric stricture were included in our study. The cases were reviewed retrospectively with regards to the etiological factor, the site of stricture, symptom and diagnosis. Six patients with ureteri... | 18,956,723 |
[Effects on lymphangiogenesis and angiogenesis of lung cancer with antisense oligonucleotides of vascular endothelial growth factor C]. | To investigate the effects on lymphangiogenesis and angiogenesis of orthotopic implantation of lung cancer in nude mice with antisense oligonucleotides of VEGF-C. The model in nude mice was established with orthotopic implantation for the human lung cancer cell line A549. Thirty nude mice were randomized into three gro... | 18,956,726 |
[The microclimate of an unoccupied wintering sett of the badger, Meles meles (Carnivora: Mustelidae), in the Darwin State Nature Reserve, Vologda Region]. | Data on the microclimate (air temperature and humidity) within an unoccupied badger sett in the Darwin Reserve (the Vologda Region) between September 2005 and May 2006 have been analyzed in relation to changes in the temperature and humidity of the ground air layer and soil. A positive correlation has been revealed bet... | 18,956,735 |
[Identification of antimicrobial susceptibility of foodborne Salmonella and related plasmid]. | We tested the antimicrobial susceptibility of 390 Salmonella isolates. We also studied the relationship between plasmids in some multidrug resistant Salmonella isolates and the antibiotic resistance profile of their hosts, as well as conjugation test of some multidrug resistant Salmonellas. Salmonella strains were isol... | 18,956,747 |
[Construction of recombinant fowlpox virus coexpressing HA from subtype H5 of avian influenza virus and chicken interleukin-18]. | We developed recombinant fowlpox viruses (rFPV) coexpressing chicken IL-18 and H5 AIV HA. Recombinant expression plasmid pSYHA/IL-18 was constructed by cloning chicken IL-18 into transfer plasmid containing HA gene and transfected by lipofectamine on the chicken embryo fibroblasts cell (CEF) pre-infected with S-FPV-017... | 18,956,750 |
[Analysis and isolation of radical scavengers from metabolites of Hirsutella sp]. | During a screening for free radical scavengers from metabolites of entomogenous fungi, we fond a fermentation broth of the strain RCEF 0881 of Hirsutella sp. exhibited strong radical scavenging activity. To make clear of the constituents of the active compounds, and prepare some pure active compound for further structu... | 18,956,752 |
[Analysis of xanthones in gamboge by HPLC-PDA-ESI/MS]. | The MS and multi-MS spectra of gambogic acid and gambogenic acid in positive ion detection mode were analyzed by electrospray ion trap mass spectrometry (ESI-QITMS) and their cleavage patterns were summarized. Gamboge samples were separated by a Kromasil C18 column and analyzed by HPLC-PDA and MS. Sixteen xanthones cou... | 18,956,777 |
[Tuberculosis epidemiology in Mayotte Island]. | Mayotte is a French territory island, part of the Comoros Archipelago in the Indian Ocean with 200,000 inhabitants. The tuberculosis control program started in 1976, although available epidemiological data remains incomplete. We conducted a retrospective hospital-based survey in 202 outpatients and hospital medical rec... | 18,956,814 |
Alkane hydroxylation by peroxy acids: a comparison with the cytochrome P450 hydroxylation. | Alkane hydroxylation by peroxy acids proceeds by a synchronous nonconcerted peroxy oxygen insertion into the C-H bond according to density functional theory. A comparable reaction sequence, initiated by homolytic peroxy bond cleavage, can be formulated for the alkane hydroxylation by the cytochrome P450 hydroperoxo-hem... | 18,956,858 |
Palladium-catalyzed formylation of aryl bromides: elucidation of the catalytic cycle of an industrially applied coupling reaction. | The first comprehensive study of the catalytic cycle of the palladium-catalyzed formylation of aryl bromides with synthesis gas (CO/H2, 1:1) is presented. The formylation in the presence of efficient (Pd/PR2(n)Bu, R = 1-Ad, (t)Bu) and nonefficient (Pd/P(t)Bu3) catalysts was investigated. The main organometallic complex... | 18,956,867 |
Dystrophic-like alterations characterize orbicularis oris and palatopharyngeal muscles in patients affected by cleft lip and palate. | This study analyzed histological and histochemical features of specimens of the orbicularis oris muscle, and palatal and pharyngeal muscles biopsied during surgery from 33 patients affected by cleft lip and palate. Three groups were studied: 20 patients affected by cleft palate with or without cleft lip (at the time of... | 18,956,931 |
Cleft lip and/or palate: 10 years experience at a pediatric cleft center in Southern Thailand. | To study the clinical characteristics, demographic data, and associated congenital anomalies of pediatric patients with cleft lip and/or palate in Southern Thailand. Retrospective, hospital-based study. Cleft Clinic Center, Songklanagarind Hospital Children with cleft lip and/or palate who were born or seen at Songklan... | 18,956,943 |
Evaluation of the Respimat Soft Mist Inhaler using a concurrent CFD and in vitro approach. | The Respimat Soft Mist Inhaler is reported to generate an aerosol with low spray momentum and a small droplet size. However, the transport characteristics of the Respimat aerosol are not well understood. The objective of this study was to characterize the transport and deposition of an aerosol emitted from the Respimat... | 18,956,950 |
HIV-related risk behaviors among female sex workers in Ho Chi Minh City, Vietnam. | This study quantitatively and qualitatively described HIV risk behaviors among Vietnamese female sex workers (FSWs) who work at three distinct venues in Ho Chi Minh City: street, massage parlors, and bars/clubs. Although 35% of the participants had never been tested for HIV, 18% of street and 7% of bar/club FSWs report... | 18,956,984 |
[Post-transplant diabetes mellitus depending on the pre-transplant dialysis technique]. | Post-transplant diabetes mellitus (PTDM) is one of the most important complications in kidney transplant patients because it has a significant impact on graft and patient survival. Diagnosis of PTDM should be based on the American Diabetic Association criteria. Recent studies show the value of performing an oral glucos... | 18,957,019 |
Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use. | There is growing consensus on the potential use of pharmacogenetics in clinical practice, and hopes have been expressed for application to the improvement of global health. However, two major challenges may lead to widening the "biotechnological gap" between the developing and the industrial world; first the unaffordab... | 18,957,039 |
Association of epidermal growth factor receptor (EGFR) gene mutations with EGFR amplification in advanced non-small cell lung cancer. | Somatic mutations in the epidermal growth factor receptor (EGFR) gene are associated with the response to EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer (NSCLC). Increased EGFR copy number has also been associated with sensitivity to these drugs. However, given that it is often difficult to... | 18,957,054 |
Novel centrosome protein, TCC52, is a cancer-testis antigen. | A novel centrosome protein, TCC52, was identified as a cancer-testis (CT) antigen. The TCC52 gene was tissue-restricted in normal tissues but highly expressed in lung cancer tissues and some cancer cell lines. Immunoglobulin G antibody specific to TCC52 was detected in serum samples from patients with prostate cancer (... | 18,957,058 |
Pre-hospital advanced airway management by anaesthesiologists: is there still room for improvement? | Endotracheal intubation is an important part of pre-hospital advanced life support that requires training and experience, and should only be performed by specially trained personnel. In Norway, anaesthesiologists serve as Helicopter Emergency Medical Service HEMS physicians. However, little is known about how they them... | 18,957,064 |
Prognostication after out-of-hospital cardiac arrest, a clinical survey. | Numerous parameters and tests have been proposed for outcome prediction in comatose out-of-hospital cardiac arrest survivors. We conducted a survey of clinical practice of prognostication after therapeutic hypothermia (TH) became common practice in Norway. By telephone, we interviewed the consultants who were in charge... | 18,957,071 |
Neutralizing human monoclonal antibody against H5N1 influenza HA selected from a Fab-phage display library. | Identification of neutralizing antibodies with specificity away from the traditional mutation prone antigenic regions, against the conserved regions of hemagglutinin from H5N1 influenza virus has the potential to provide a therapeutic option which can be developed ahead of time in preparation for a possible pandemic du... | 18,957,074 |
Dual-hemisphere tDCS facilitates greater improvements for healthy subjects' non-dominant hand compared to uni-hemisphere stimulation. | Transcranial direct current stimulation (tDCS) is a non-invasive technique that has been found to modulate the excitability of neurons in the brain. The polarity of the current applied to the scalp determines the effects of tDCS on the underlying tissue: anodal tDCS increases excitability, whereas cathodal tDCS decreas... | 18,957,075 |
NG2 cells response to axonal alteration in the spinal cord white matter in mice with genetic disruption of neurofilament light subunit expression. | Chondroitin sulphate proteoglycan (NG2) expressing cells, morphologically characterized by multi-branched processes and small cell bodies, are the 4th commonest cell population of non-neuronal cell type in the central nervous system (CNS). They can interact with nodes of Ranvier, receive synaptic input, generate action... | 18,957,081 |
Spectrum of heart diseases in a new cardiac service in Nigeria: an echocardiographic study of 1441 subjects in Abeokuta. | Echocardiography is a non-invasive, relatively cheap and useful imaging technique for the evaluation of cardiac diseases. The procedure has reliable levels of accuracy. Echocardiography commenced at the Federal medical centre Abeokuta on September 9, 2005.The aim of this study is to report our experience with the proce... | 18,957,102 |
Severe maternal morbidity (near miss) as a sentinel event of maternal death. An attempt to use routine data for surveillance. | To identify all the records within the Brazilian Hospital Information System (HIS) that contained information suggestive of severe maternal morbidity (near miss); to describe the diagnoses and procedures used; to identify variables associated with maternal death. A descriptive population study with data from the HIS an... | 18,957,110 |
Giant fibrovascular polyp of the oesophagus: a case report and review of the literature. | We present a case of fibrovascular polyp, a rare submucosal tumour of the oesophagus that has been reported only sporadically in the literature. The biapproach for surgical removal of fibrovascular polyp has only been mentioned once in the literature. A 65-year-old Greek man presented with a 9-month history of graduall... | 18,957,112 |
Careers in ecstasy use: do ecstasy users cease of their own accord? Implications for intervention development. | Ecstasy (MDMA, 3, 4-methylenodioxymethamphetamine) use is widespread in the Netherlands, with a lifetime prevalence of 4.3%, and two-thirds of dance party visitors being ecstasy users. However, research into Dutch ecstasy use patterns is lacking. In addition, recent studies suggest that ecstasy users cease their use au... | 18,957,117 |
MetaMine--a tool to detect and analyse gene patterns in their environmental context. | Modern sequencing technologies allow rapid sequencing and bioinformatic analysis of genomes and metagenomes. With every new sequencing project a vast number of new proteins become available with many genes remaining functionally unclassified based on evidences from sequence similarities alone. Extending similarity sear... | 18,957,118 |
Practice of noninvasive ventilation for cystic fibrosis: a nationwide survey in France. | No guidelines are available for noninvasive ventilation (NIV) for cystic fibrosis (CF). To survey and evaluate the use of NIV for CF in France. We surveyed the coordinator physicians of every accredited CF center in France. The respondents represented 36 centers (15 pediatric centers, 13 adult centers, and 8 centers th... | 18,957,151 |
Effect of pH and water-soluble polymers on the aqueous solubility of nimesulide in the absence and presence of beta-cyclodextrin derivatives. | The aqueous solubility of nimesulide in the absence and presence of beta-cyclodextrin (beta-CD) and its alkyl derivatives hydroxypropyl-beta-CD and methyl-beta-CD was studied. We also investigated the effect of water-soluble polymers, hydroxypropylmethyl-cellulose, sodium-carboxymethyl-cellulose, polyvinylpyrrolidone a... | 18,957,163 |
Pharmacological and local toxicity studies of a liposomal formulation for the novel local anaesthetic ropivacaine. | This study reports an investigation of the pharmacological activity, cytotoxicity and local effects of a liposomal formulation of the novel local anaesthetic ropivacaine (RVC) compared with its plain solution. RVC was encapsulated into large unilamellar vesicles (LUVs) composed of egg phosphatidylcholine, cholesterol a... | 18,957,165 |
Design and synthesis of new symmetrical derivatives of dihydropyridine containing a pyridyl group on the 3, 5-positions and evaluation of their cytotoxic and multidrug resistance reversal activity. | Today, chemotherapy is an important part in the treatment of several kinds of cancer; however, the development of drug resistance remains one of the major obstacles in successful chemotherapy. Several types of agents have been recognized as multidrug resistance (MDR) inhibitors, among which the 1,4-dihydropyridines (DH... | 18,957,169 |
HIV-associated neurocognitive disorders and the impact of combination antiretroviral therapies. | HIV-associated neurocognitive disorders (HAND) are the most common preventable and treatable cause of dementia. While the incidence of the most severe form of HAND, HIV-associated dementia, has decreased since the introduction of combination antiretroviral therapy (cART), the prevalence of less severe forms of HAND has... | 18,957,181 |
Nuclear roadblocks for mRNA export. | The THO complex and Sub2 RNA helicase have been shown to function in both transcription and mRNA processing. Rougemaille et al. (2008) now uncover evidence that THO/Sub2 coordinates mRNA processing and nuclear export. | 18,957,194 |
Kinetochores and microtubules wed without a ring. | Proper chromosome segregation in mitosis requires tethering of spindle microtubules to the kinetochore. Using electron tomography of mammalian cells, McIntosh et al. (2008) now report the presence of fibrils that connect the inner kinetochore to the curved protofilaments at microtubule ends, suggesting a new model for ... | 18,957,196 |
Nature, nurture, or chance: stochastic gene expression and its consequences. | Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to cell-to-cell variations in mRNA and protein levels. This variation appears in organisms ranging from microbes to metazoans, and its characteristics depend both on the biophysical parameters governing gene ... | 18,957,198 |
The hippocampus and dopaminergic midbrain: old couple, new insights. | Humans have a natural ability to gain new insights by generalizing from previous experience. In this issue of Neuron, Shohamy and Wagner reveal how generalizations naturally emerge during associative learning through a partnership between putatively dopaminergic circuitry in the midbrain and the hippocampus. | 18,957,213 |
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. | Neuronal migration is a fundamental component of brain development whose failure is associated with various neurological and psychiatric disorders. Reelin is essential for the stereotypical inside-out sequential lamination of the neocortex, but the molecular mechanisms of its action still remain unclear. Here we show t... | 18,957,219 |
Human cortex: reflections of mirror neurons. | Claims to have identified mirror neurons in human cortex have been controversial. A recent study has applied an fMRI adaptation protocol to the problem and come up with novel evidence for the existence of movement-selective mirror neurons in human cortex. | 18,957,251 |
Association between individual differences in self-reported emotional resilience and the affective perception of neutral faces. | Resilience, i.e., the ability to cope with stress and adversity, relies heavily on judging adaptively complex situations. Judging facial emotions is a complex process of daily living that is important for evaluating the affective context of uncertain situations, which could be related to the individual's level of resil... | 18,957,273 |
Methyltransferase-inhibition interferes with neuronal differentiation of P19 embryonal carcinoma cells. | We have analyzed the importance of substrate methylation by S-adenosylmethionine-dependent methyltransferases for neuronal differentiation of P19 embryonal carcinoma cells. We show that treatment of cells with methyltransferase inhibitor adenosine dialdehyde (AdOx) interferes with neuronal differentiation. Retinoic aci... | 18,957,285 |
Source of the elevation Ca2+ evoked by 15-HETE in pulmonary arterial myocytes. | We have previously reported that 15-hydroxyeicosatetraenoic acid (15-HETE), a metabolite of arachidonic acid by 15-lipoxygenase, causes pulmonary vasoconstriction via increasing the intracellular Ca(2+) concentration ([Ca(2+)]i). However, the multiple sources of Ca(2+) that contribute to Ca(2+) elevation during and aft... | 18,957,290 |
Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences. | We have previously shown gonadal steroid-dependent, gender specific modulation of nociception by alpha(2)-adrenoceptors. Agonist activation of the receptor enhances its association with spinophilin that antagonizes arrestin functions both by diminishing receptor phosphorylation by G-protein-coupled receptor kinase 2 (G... | 18,957,308 |
Evaluation of candidate reference genes in Q-PCR studies of Atlantic cod (Gadus morhua) ontogeny, with emphasis on the gastrointestinal tract. | To obtain reliable relative qPCR data in developing fish larvae, stable reference genes have to be found. This study is focused on finding good candidates for normalization of qPCR data for ontogenetic studies of Atlantic cod. Ten commonly used reference genes; Acidic ribosomal protein, Actin-related protein 2, beta-ac... | 18,957,329 |
First population study of the general public awareness and perception of epilepsy in Bosnia and Herzegovina. | Public knowledge of, perception of, and attitudes toward epilepsy in Bosnia and Herzegovina (BH) were studied for the first time. One thousand randomly selected adults were asked 12 questions about epilepsy. Ninety-one percent (91%) of respondents had heard about epilepsy, 41% knew someone with epilepsy, 32.5% had witn... | 18,957,332 |
Unravelling the nuclear matrix proteome. | The nuclear matrix (NM) model posits the presence of a protein/RNA scaffold that spans the mammalian nucleus. The NM proteins are involved in basic nuclear function and are a promising source of protein biomarkers for cancer. Importantly, the NM proteome is operationally defined as the proteins from cells and tissue th... | 18,957,335 |
Crucial cytokine interactions in nitric oxide production induced by Mycoplasma arthritidis superantigen. | Mycoplasma arthritidis causes autoimmune arthritis in rodents. It produces a superantigen (MAM) that simultaneously activates antigen presenting cells and T cells inducing nitric oxide and cytokine release. Nitric oxide is a key inducer and regulator of the immune system activation. Here, we investigated nitric oxide a... | 18,957,330 |
[Fruit of the emergence of an enterovirus: acute haemorrhagic conjunctivitis]. | First seen in Ghana and Indonesia in the early 70's, acute haemorrhagic conjunctivitis or "Apollo 11" disease is an eye infection caused by Enterovirus type 70 (EV70). The disease appeared to be a highly contagious conjunctivitis which spread rapidly all over the world. EV70 has been considered as an emerging virus and... | 18,957,336 |
[CSF: diagnosis of neurosyphilis in a patient hospitalized for an acute brain stroke]. | We report the case of a sixty-eight years old patient, who was admitted to the emergency for paresthesis associated with dysarthra and speech complaints. Neuroimaging revealed the presence of stenosis caused by arteritis. The notion of history of syphilis infection led to diagnosis of neurosyphilis. Diagnosis is diffic... | 18,957,346 |
[Meningoencephalitis due to community Klebsiella pneumoniae in an adult immunocompetent: a case report]. | We report the first Moroccan case of community-acquired meningoencephalitis due to Klebsiella pneumoniae in an adult immunocompetent without medical history, complicated of cerebral vasculitis and right endophthalmitis. K. pneumoniae is exceptionally responsible for meningitis community in the world excepted in some co... | 18,957,347 |
Testing the island rule: primates as a case study. | The island rule states that after island colonization, larger animals tend to evolve reduced body sizes and smaller animals increased sizes. Recently, there has been disagreement about how often, if ever, this rule applies in nature, and much of this disagreement stems from differences in the statistical tests employed... | 18,957,368 |
The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations. | The Na+,K+-ATPase transforms the energy of ATP to the maintenance of steep electrochemical gradients for sodium and potassium across the plasma membrane. This activity is tissue specific, in particular due to variations in the expressions of the alpha subunit isoforms one through four. Several mutations in alpha2 and 3... | 18,957,371 |
Review. ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator. | Proteins belonging to the ATP-binding cassette superfamily couple ATP binding and hydrolysis at conserved nucleotide-binding domains (NBDs) to diverse cellular functions. Most superfamily members are transporters, while cystic fibrosis transmembrane conductance regulator (CFTR), alone, is an ion channel. Despite this f... | 18,957,373 |
Review. The mammalian proton-coupled peptide cotransporter PepT1: sitting on the transporter-channel fence? | The proton-coupled di- and tripeptide transporter PepT1 (SLC15a1) is the major route by which dietary nitrogen is taken up from the small intestine, as well as being the route of entry for important therapeutic (pro)drugs such as the beta-lactam antibiotics, angiotensin-converting enzyme inhibitors and antiviral and an... | 18,957,377 |
Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism. | Isoproterenol treatment of Brown Norway and Lewis rats (high and low plasma angiotensin-I-converting enzyme activity, respectively) results in similar cardiac hypertrophy but higher cardiac fibrosis in Brown Norway rats. Rats were infused in vivo with isoproterenol for two or 10 days. Cardiac fibrosis and inflammation ... | 18,957,386 |
Rexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1. | The synthetic rexinoid bexarotene (Targretin, LGD1069) inhibits the formation of both estrogen receptor-negative and estrogen receptor-positive breast cancer in preclinical models and controls the expression of growth-regulatory biomarkers, such as IGFBP-6 (insulin-like growth factor-binding protein 6), RARbeta, or cyc... | 18,957,410 |
The essential cytosolic iron-sulfur protein Nbp35 acts without Cfd1 partner in the green lineage. | In photosynthetic eukaryotes assembly components of iron-sulfur (Fe-S) cofactors have been studied in plastids and mitochondria, but how cytosolic and nuclear Fe-S cluster proteins are assembled is not known. We have characterized a plant P loop NTPase with sequence similarity to Nbp35 of yeast and mammals, a protein o... | 18,957,412 |
tRNAdb 2009: compilation of tRNA sequences and tRNA genes. | One of the first specialized collections of nucleic acid sequences in life sciences was the 'compilation of tRNA sequences and sequences of tRNA genes' (http://www.trna.uni-bayreuth.de). Here, an updated and completely restructured version of this compilation is presented (http://trnadb.bioinf.uni-leipzig.de). The new ... | 18,957,446 |
Increased prevalence of white matter hyperintensities in patients with panic disorder. | The aim of the current study is to compare the prevalence, severity and location of cerebral white matter hyperintensities (WMH) between patients with panic disorder (PD) and healthy control subjects. Patients with PD (n = 24) and matched healthy control subjects (n = 24) were scanned using a 3.0 Tesla whole-body magne... | 18,957,476 |
Annotation of tertiary interactions in RNA structures reveals variations and correlations. | RNA tertiary motifs play an important role in RNA folding and biochemical functions. To help interpret the complex organization of RNA tertiary interactions, we comprehensively analyze a data set of 54 high-resolution RNA crystal structures for motif occurrence and correlations. Specifically, we search seven recognized... | 18,957,492 |
Dissecting the involvement of formins in Bud6p-mediated cortical capture of microtubules in S. cerevisiae. | In S. cerevisiae, spindle orientation is linked to the inheritance of the ;old' spindle pole by the bud. A player in this asymmetric commitment, Bud6p, promotes cortical capture of astral microtubules. Additionally, Bud6p stimulates actin cable formation though the formin Bni1p. A relationship with the second formin, B... | 18,957,510 |
Altered gene expression profiles define pathways in colorectal cancer cell lines affected by celecoxib. | It is well established that celecoxib, a selective inhibitor of cyclooxygenase-2 (COX-2) and a tested chemopreventive agent, has several COX-2-independent activities. In an attempt to better understand COX-2-independent molecular mechanisms underlying the chemopreventive activity of celecoxib, we did global transcripti... | 18,957,522 |
Association between alcohol intake and serum sex hormones and peptides differs by tamoxifen use in breast cancer survivors. | To measure the association between alcohol intake and 11 hormones and peptides in postmenopausal breast cancer survivors and to evaluate whether this association differs by tamoxifen use. Self-reported alcohol intake was assessed via food frequency questionnaire on average 30 months post-breast cancer diagnosis in 490 ... | 18,957,523 |
Wnt-mediated self-renewal of neural stem/progenitor cells. | In this work we have uncovered a role for Wnt signaling as an important regulator of stem cell self-renewal in the developing brain. We identified Wnt-responsive cells in the subventricular zone of the developing E14.5 mouse brain. Responding cell populations were enriched for self-renewing stem cells in primary cultur... | 18,957,545 |
A model of efficiency: stress tolerance by Streptococcus mutans. | The complete genome sequence of Streptococcus mutans, a bacterial pathogen commonly associated with human dental caries, was published in 2002. The streamlined genome (2.03 Mb) revealed an organism that is well adapted to its obligately host-associated existence in multispecies biofilms on tooth surfaces: a dynamic env... | 18,957,579 |
Additive attenuation of virulence and cariogenic potential of Streptococcus mutans by simultaneous inactivation of the ComCDE quorum-sensing system and HK/RR11 two-component regulatory system. | The genome of Streptococcus mutans harbours 13 two-component signal transduction systems (TCSTSs). Of these, a peptide-mediated quorum-sensing system, ComCDE, and the HK/RR11 two-component system are well known to regulate several virulence-associated traits in in vitro experiments, including genetic competence, bacter... | 18,957,580 |
L-Cysteine is required for induced antibiotic resistance in actively swarming Salmonella enterica serovar Typhimurium. | Swarm-cell differentiation in Salmonella enterica serovar Typhimurium (S. typhimurium) results in a biosynthetic mode of growth, despite growing on a rich medium, and cells that have elevated antibiotic resistance. These phenotypes are not a prerequisite for swarm motility. By blocking the switch to anabolic growth usi... | 18,957,594 |
A comparative study of host response to three Mycobacterium tuberculosis PE_PGRS proteins. | Three Mycobacterium tuberculosis proteins, PE_PGRS 16 (Rv0977), PE_PGRS 26 (Rv1441c) and PE_PGRS 33 (Rv1818c), were expressed in Mycobacterium smegmatis and used to investigate the host response to members of this unique protein family. Following infection of macrophages with the recombinant M. smegmatis (Ms) strains, ... | 18,957,600 |
AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix. | High-grade gliomas release excitotoxic concentrations of glutamate, which has been shown to enhance tumor proliferation and migration. alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) glutamate receptors are abundantly expressed at the invading edge of glioblastoma specimens, suggesting they may play an ... | 18,957,620 |
Addition of thiazolidinedione or exenatide to oral agents in type 2 diabetes: a meta-analysis. | The introduction of several new therapeutic agents for the treatment of type 2 diabetes mellitus has led to significant challenges for providers in deciding which agent to select during the disease course. To provide a relative comparison of the efficacy and safety of adding thiazolidinediones (TZDs) or exenatide to or... | 18,957,626 |
Occurrence of mycoplasmas in free-ranging birds of prey in Germany. | Mycoplasmas are well-known avian pathogens of poultry and some passerines. Although reported in birds of prey, their role as pathogens is still unclear. Healthy, free-ranging raptor nestlings sampled during a routine ringing (banding) program, and birds of prey from rehabilitation centers, tested positive for Mycoplasm... | 18,957,640 |
Ranavirus infection of free-ranging and captive box turtles and tortoises in the United States. | Iridoviruses of the genus Ranavirus are well known for causing mass mortality events of fish and amphibians with sporadic reports of infection in reptiles. This article describes five instances of Ranavirus infection in chelonians between 2003 and 2005 in Georgia, Florida, New York, and Pennsylvania, USA. Affected spec... | 18,957,641 |
Prevalence of tetracycline and rabies virus antibody in raccoons, skunks, and foxes following aerial distribution of V-RG baits to control raccoon rabies in Ontario, Canada. | More than 3.6 million baits containing a recombinant vaccinia virus-rabies glycoprotein (V-RG) oral rabies vaccine were aerially or hand-distributed during 1999-2006 in an approximate 4,000-9,000 km(2) area of eastern Ontario, Canada, as part of a multitactic approach to control the raccoon variant of rabies. The effic... | 18,957,651 |
The HIF-1 alpha-C/EBP alpha axis. | The hypoxia inducible factors (HIFs) and CCAAT/enhancer binding protein alpha (C/EBP alpha) are transcription factors that mediate adaptive responses to hypoxia and control aspects of energy metabolism, respectively. New evidence suggests that when HIF-1 alpha and C/EBP alpha interact, they bring about reciprocal funct... | 18,957,690 |
Positron-emission tomography in imaging and staging prostate cancer. | With increasing application of positron-emission tomography (PET) imaging, familiarity with the applications of PET in genitourinary oncology, especially prostate-cancer (PCa) imaging, becomes important. PET studies provide functional information using radiolabeled tracers, with fluoro-dexoxy-glucose (FDG) being the mo... | 18,957,716 |
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