title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Copper catalysts for soot oxidation: alumina versus perovskite supports. | Copper catalysts prepared using four supports (Mg- and Sr-modified Al2O3 and MgTiO3 and SrTiO3 perovskites) have been tested for soot oxidation by 02 and NOx/O2. Among the catalysts studied, Cu/SrTiO3 is the most active for soot oxidation by NOx/O2 and the support affects positively copper activity. With this catalyst,... | 18,983,091 |
Validation of dietary intake of dichlorodiphenyltrichloroethane and metabolites in two populations from Beijing and Shenyang, China based on the residuals in human milk. | This paper presents the results of an investigation on association between dietary intakes and human milk concentrations of dichlorodiphenyltrichloroethane and metabolites (DDTs) of two populations from Beijing and Shenyang, China. We analyzed human milk samples from 76 women and 287 composite food samples covering maj... | 18,983,097 |
Factors associated with advance care planning among older women in Southwest Florida. | As the nation's population continues to age, many older women will face care needs that can be anticipated in advance. However, little is known about the advance care plans of older women and the characteristics of those who plan. This study utilized a stratified random sampling design to survey older women (n = 124) i... | 18,983,110 |
Rehabilitation programs for elderly women inpatients with schizophrenia. | This study aims to describe rehabilitation and resocialization methods we believe to be appropriate for application to female patients with schizophrenia, in a psychiatric unit with a predominantly older population. We briefly describe the unit and the interventions used as an example of the proposed rehabilitation and... | 18,983,112 |
Temperature-induced route to chaos in the H2O2-HSO3(-)-S2O3(2-) flow reaction system. | Low-frequency, high-amplitude pH-oscillations observed experimentally in the H2O2-HSO3(-)-S2O3(-) flow reaction system at 21.0 degrees C undergo period-doubling cascades to chemical chaos upon decreasing the temperature to 19.0 degrees C in small steps. Period-4 oscillations are observed at 20.0 degrees C and can be ca... | 18,983,129 |
New lipophilic tyrosyl esters. Comparative antioxidant evaluation with hydroxytyrosyl esters. | New lipophilic esters of tyrosol, a naturally occurring phenol with interesting biological properties, have been synthesized in good yields by a chemoselective procedure, using lipase from Candida antarctica or p-toluenesulfonic acid as catalysts. Their antioxidant activities have been evaluated by the Rancimat test in... | 18,983,160 |
Optimization of lipase-catalyzed synthesis of ginsenoside Rb1 esters using response surface methodology. | In the lipase (Novozyme 435)-catalyzed synthesis of ginsenoside Rb1 esters, different acyl donors were found to affect not only the degree of conversion but also the regioselectivity. The reaction of acyl donors with short carbon chain was more effective, showing higher conversion than those with long carbon chain. Amo... | 18,983,161 |
Loss of ripening capacity of pawpaw fruit with extended cold storage. | The fruit ripening traits of pawpaw [ Asimina triloba (L.) Dunal] were examined after harvest and after cold storage at -2, 2, 4, and 6 degrees C for up to 12 weeks. Generally, fruits stored at 2-4 degrees C for 4 weeks ripened normally, but those stored at -2 degrees C did not ripen normally, those stored at 6 degrees... | 18,983,162 |
Pseudoirreversible inhibition of prostate-specific membrane antigen by phosphoramidate peptidomimetics. | The mode of inhibition for phosphoramidate peptidomimetic inhibitors of prostate-specific membrane antigen was determined by inhibition reversibility experiments. The results revealed that these inhibitors can be classified into three types: pseudoirreversible (compounds 1-3), moderately reversible (compounds 4-9), and... | 18,983,168 |
Shedding new light on the molecular architecture of oocytes using a combination of synchrotron Fourier transform-infrared and Raman spectroscopic mapping. | Synchrotron Fourier transform-infrared (FT-IR) and Raman microspectroscopy were applied to investigate changes in the molecular architecture of mouse oocytes and demonstrate the overall morphology of the maturing oocyte. Here we show that differences were identified between immature mouse oocytes at the germinal vesicl... | 18,983,174 |
Aprotinin and renal dysfunction. | Aprotinin is a polypeptide serine protease inhibitor used to prevent bleeding and need for transfusions in patients having heart surgery. A recent analysis of an observational study data set suggested the use of aprotinin was associated with an increased risk of developing renal failure. The present article reviews the... | 18,983,214 |
Smoking cessation in pregnancy. | Pregnant women who continue to smoke expose their developing fetus to a wide range of risks. Assisting these patients to stop smoking can be an important intervention for the health of the baby and the mother. The management of pregnant smokers can be challenging, due to the potential risks of pharmacotherapy. There ar... | 18,983,219 |
Targeting important pathways in head and neck cancer: from the bench to the clinic. | Radiation therapy as single or combined modality (concurrent chemoradiotherapy) has been the cornerstone of treatment for squamous cell carcinoma of the head and neck for a long time. Fortunately, advances in tumor biology have provided new insights of tumor proliferation, metastases, migration and cell cycle regulatio... | 18,983,242 |
Imbalanced distribution of GM immunoglobulin allotypes according to the clinical presentation of Plasmodium falciparum malaria in Beninese children. | Selection pressure exerted by pathogens contributes to the persistence of polymorphisms in GM and KM allotypes, which are antigenic determinants of immunoglobulins. This study investigated the impact of GM and KM allotypes on the clinical response to Plasmodium falciparum infection among Beninese children, including 65... | 18,983,245 |
Cardiac differentiation is driven by NKX2.5 and GATA4 nuclear translocation in tissue-specific mesenchymal stem cells. | Myocardial infarction is a major public health problem that causes significant mortality despite recent advances in its prevention and treatment. Therefore, approaches based on adult stem cells represent a promising alternative to conventional therapies for this life-threatening condition. Mesenchymal stem cells (MSCs)... | 18,983,250 |
A novel telemedicine system for monitoring congestive heart failure patients. | Congestive heart failure is a widespread cardiac disease in western countries. At present, the main measure for monitoring the level of pulmonary edema in telemedicine systems is weight, which is not a reliable indicator. The authors propose a novel bioimpedance telemedical system to monitor these patients. The system ... | 18,983,286 |
Ten-year secular trends for congestive heart failure hospitalizations: an analysis of regional differences in the United States. | This study used data from the National Hospital Discharge Survey to examine secular trends and regional variation in hospitalization rates for congestive heart failure. The hospitalization rate for congestive heart failure rose significantly between 1995 and 2004 for adults aged 35 to 64 years. This trend was particula... | 18,983,290 |
Lupus syndrome with neutropenia following minocycline therapy - a case report. | An 18-year-old patient is described who presented with febrile neutropenia and hepatitis caused by minocycline therapy. This rare complication of minocycline-induced lupus syndrome is discussed here. | 18,983,308 |
Trichosporon mucoides fungemia in a liver transplant recipient: case report and review. | Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus. During his hospitalization he experienced bloodstream infections including fungemia due to Trichosporon mucoides and prolonged undu... | 18,983,414 |
Morphological, biochemical and molecular characterisation of the first Italian Candida africana isolate. | One atypical isolate of the pathogenic yeast Candida albicans was isolated from an Italian patient with vulvovaginitis. The strain, germ tube positive and chlamydospore-negative showed white-thin turquoise colonies on Candida ID 2 medium. The yeast was identified as Candida africana by using morphological and biochemic... | 18,983,430 |
Hyperzincemia and hypercalprotectinemia: unsuccessful treatment with tacrolimus. | We report on a 5-year-old boy with hyperzincemia and hypercalprotectinemia. Treatment began with Tacrolimus at the age of 4 years and 6 months. Despite an initial correction of clinical and biological symptoms, zincemia and calprotectinemia progressively worsened with secondary reappearance of symptoms. Tacrolimus seem... | 18,983,438 |
Blood volume, blood pressure and total body sodium: internal signalling and output control. | Total body sodium and arterial blood pressure (ABP) are mutually dependent variables regulated by complex control systems. This review addresses the role of ABP in the normal control of sodium excretion (NaEx), and the physiological control of renin secretion. NaEx is a pivotal determinant of ABP, and under experimenta... | 18,983,442 |
Oxygen-dependent ion transport in erythrocytes. | The present contribution reviews current knowledge of apparently oxygen-dependent ion transport in erythrocytes and presents modern hypotheses on their regulatory mechanisms and physiological roles. In addition to molecular oxygen as such, reactive oxygen species, nitric oxide, carbon monoxide, regional variations of c... | 18,983,458 |
Renal medullary effects of transient prehypertensive treatment in young spontaneously hypertensive rats. | Transient angiotensin II receptor blockade (ARB) leads to prolonged blood pressure (BP) lowering, but the underlying mechanism remains uncertain. Long-term BP control is regulated by the medullary microcirculation with the pericyte as contractile cell. We hypothesize that the prolonged BP effect is caused by increased ... | 18,983,459 |
Can morphology predict 1p/19q loss in oligodendroglial tumours? | To investigate the relationship between phenotype and genotype in oligodendroglial tumours and evaluate whether 1p/19q status can be reliably predicted from histological findings. Three neuropathologists reviewed the association between 10 histological variables, location and genetic losses at 1p, 19q and 17p13 in 63 o... | 18,983,467 |
Development of targeted angiogenic medicine. | Strategies to alter angiogenesis have been successfully translated from the bench to bedside. With an estimated number of more than 500 million patients worldwide potentially benefiting from it, it is a prime example of targeted therapy that is increasingly changing the face of clinical medicine. Most efforts to stimul... | 18,983,480 |
Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading on collagen. | Nitric oxide (NO) inhibits platelet adhesion to collagen, although the precise molecular mechanisms underlying this process are unclear. Collagen-mediated adhesion is a multifaceted event requiring multiple receptors and platelet-derived soluble agonists. We investigated the influence of NO on these processes. S-nitros... | 18,983,487 |
Elevated platelet and leukocyte response to oral bacteria in periodontitis. | Periodontitis is associated with an increased risk for cardiovascular diseases (CVD), but the underlying mechanisms are poorly understood. Recently, we showed that platelets from periodontitis patients are more activated than those from controls. Given the regularly occurring bacteremic episodes in periodontitis patien... | 18,983,491 |
Guidelines and the use of inferior vena cava filters: a review of an institutional experience. | Based on the American College of Chest Physicians 2004 antithrombotic therapy for venous thromboembolism (VTE) and the Eastern Association for the Surgery of Trauma 2002 guidelines, placement of an inferior vena cava (IVC) filter is indicated in patients who either have, or are at high risk for, VTE, but have a contrai... | 18,983,493 |
Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model. | Atherothrombosis is a major cause of cardiovascular events. However, animal models to study this process are scarce. We describe the first murine model of acute thrombus formation upon plaque rupture to study atherothrombosis by intravital fluorescence microscopy. Localized rupture of an atherosclerotic plaque in a car... | 18,983,512 |
Heparin-induced thrombocytopenia--therapeutic concentrations of danaparoid, unlike fondaparinux and direct thrombin inhibitors, inhibit formation of platelet factor 4-heparin complexes. | Treatment of heparin-induced thrombocytopenia (HIT), a disorder in which anti-platelet factor 4 (PF4)-heparin antibodies cause platelet activation and hypercoagulability, requires alternative (non-heparin) anticoagulation. Treatment options include direct thrombin inhibitors [lepirudin and argatroban (approved), and bi... | 18,983,520 |
Ida Mann Lecture 2007: Planet eye. | The concept for this lecture arose as a consequence of the invitation from the College to give the 'Ida Mann Lecture' arriving recently after I had enjoyed the beautiful David Attenborough series 'Planet Earth' on television. It struck me as not too fanciful an idea at the time to make an analogy between 'Planet Earth'... | 18,983,543 |
Nucleus extraction in sutureless surgery: getting hooked! | Simple modifications to a readily available disposable 25 gauge cannula facilitate nucleus extraction in sutureless extracapsular cataract surgery. A case series using the modified cannula, and a temporal incision approach, are presented. Outcomes and complications attributable to the use of the cannula are discussed. | 18,983,544 |
Methods for studying the physiology of kidney oxygenation. | 1. An improved understanding of the regulation of kidney oxygenation has the potential to advance preventative, diagnostic and therapeutic strategies for kidney disease. Here, we review the strengths and limitations of available and emerging methods for studying kidney oxygen status. 2. To fully characterize kidney oxy... | 18,983,577 |
Effects of in utero exposure to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) on somatic growth and endocrine status in rat offspring. | Exposure to polychlorobiphenyl (PCB) mixtures at an early stage of development has been reported to affect endocrine glands; however, little is known about the precise toxicological properties of individual PCB. The present study was undertaken to determine whether prenatal exposure to 2,2',4,4',5,5'-hexachlorobiphenyl... | 18,983,581 |
Reliability and repeatability of the Pentacam on corneal curvatures. | The purpose of this study was to assess the intra-observer reliability and inter-session repeatability of the Pentacam system (Oculus, Inc.) on the simulated keratometry readings (Sim K) and peripheral corneal curvatures (PCC) at both the anterior and posterior corneal surfaces. One eye was randomly selected from each ... | 18,983,633 |
Cardiogenic shock as a complication of acute mitral valve regurgitation following posteromedial papillary muscle infarction in the absence of coronary artery disease. | A 48 year old man was transferred to our department with cardiogenic shock, pyrexia, a high white cell count and significant serum troponin T level. Clinical evaluation revealed severe mitral regurgitation secondary to a flail of both mitral valve leaflets. An emergency cardiac catheterisation did not reveal any signif... | 18,983,645 |
Empowering employees with chronic diseases; development of an intervention aimed at job retention and design of a randomised controlled trial. | Persons with a chronic disease are less often employed than healthy persons. If employed, many of them experience problems at work. Therefore, we developed a training programme aimed at job retention. The objective of this paper is to describe this intervention and to present the design of a study to evaluate its effec... | 18,983,652 |
The incidence of interstitial lung disease 1995-2005: a Danish nationwide population-based study. | Current data on incidence of interstitial lung diseases (ILDs) are sparse and concerns about an increasing trend have been raised. We examined incidence rates (IRs) of ILDs and changes in IRs between 1995 and 2005. All persons with a first-time hospital discharge or outpatient diagnosis of ILD were identified through t... | 18,983,653 |
Geographic disparities in the risk of perforated appendicitis among children in Ohio: 2001-2003. | Rural-urban disparities in health and healthcare are often attributed to differences in geographic access to care and health seeking behavior. Less is known about the differences between rural locations in health care seeking and outcomes. This study examines how commuting patterns in different rural areas are associat... | 18,983,666 |
Networks for all. | A report on the Cold Spring Harbor Laboratory/Wellcome Trust conference on Network Biology, Hinxton, UK, 27-31 August 2008. | 18,983,700 |
X-chromosome inactivation: the molecular basis of silencing. | X-chromosome inactivation occurs randomly for one of the two X chromosomes in female cells during development. Inactivation occurs when RNA transcribed from the Xist gene on the X chromosome from which it is expressed spreads to coat the whole X chromosome. In the first issue of Epigenetics and Chromatin, Nesterova and... | 18,983,701 |
Barbiturates for the treatment of intracranial hypertension after traumatic brain injury. | In their article on the use of barbiturates for the treatment of intracranial hypertension after traumatic brain injury, Perez-Barcena and colleagues conclude that thiopental was more effective than pentobarbital in decreasing intracranial pressure. Here we discuss the limitations of this study and review areas of cont... | 18,983,702 |
Year in review 2007: Critical Care--intensive care unit management. | With the development of new technologies and drugs, health care is becoming increasingly complex and expensive. Governments and health care providers around the world devote a large proportion of their budgets to maintaining quality of care. During 2007, Critical Care published several papers that highlight important a... | 18,983,704 |
Year in review 2007: Critical Care--multiple organ failure and sepsis. | Several research papers published in Critical Care throughout 2007 examined the pathogenesis, diagnosis, treatment and prognosis of sepsis and multiorgan failure. The present review summarizes the findings and implications of the papers published on sepsis and multiorgan failure and places the research in the context o... | 18,983,708 |
Antimicrobial resistance in swine production. | Large amounts of antimicrobial agents are still being used in modern swine production in many countries around the world. This facilitates the emergence and development of antimicrobial resistance. Bacteria causing infections in swine have in several cases acquired resistance to a number of the agents most commonly use... | 18,983,723 |
Assisted reproductive technology: perspectives in Halakha (Jewish religious law). | The Jewish religion is characterized by a strict association between faith and practical precepts. In principle, Jewish law has two divisions, the Written and the Oral traditions. The foundation of the Written Law and the origin of authority is the Torah, the first five books of the Scripture. This paper presents the a... | 18,983,733 |
The Greek Orthodox position on the ethics of assisted reproduction. | In dealing with reproduction, the Church believes that every human being has a beginning but has no end; this is why conception constitutes an event of unique importance. The exact moment of the beginning of life is unknown to man, but the logic of sexual intercourse without reproduction and of reproduction without sex... | 18,983,734 |
A Catholic ethical approach to human reproductive technology. | This article presents the Catholic Christian tradition and teaching on the moral respect due to human life from conception, supported by natural law moral philosophical reasoning. This approach contrasts with the ethical views of secular philosophers on human embryo research for therapeutic purposes. The challenges for... | 18,983,736 |
Magnetic resonance and diffusion-weighted imaging findings of herpes simplex encephalitis. | Herpes simplex encephalitis (HSE) is a rare, life-threatening disease. This paper draws attention to the role of imaging in early HSE diagnosis. Five consecutive patients diagnosed with HSE (type 1) between June 2005 and June 2006 (three males, two females, mean age 44 [range 16-68] years) were included in this retrosp... | 18,983,763 |
[Effect of beta-elemene on the proliferation, migration and RhoA expression of hepatic stellate cells induced by angiotensin II]. | To explore the influence of beta-elemene on the proliferation, migration and RhoA expression of hepatic stellate cells (HSC) induced by angiotensin II (ANG II). HSC were incubated in vitro. Proliferation and migration of the HSC were induced by ANG II. The effect on the proliferation of HSC was determined by MTT colori... | 18,983,771 |
Emergency thyroidectomy in infected thyroid cyst due to spontaneous gas forming organisms. | We are reporting a case of a young female, who presented to emergency room with sudden increase in thyroid swelling, high fever and acute respiratory distress. Clinical diagnosis of spontaneous infection of thyroid cyst was made. Operative finding was infection of thyroid cyst with gas formation. Systemic antibiotics a... | 18,983,798 |
Prevalence of antibodies and cell mediated immune response against Leishmania major in feral nonhuman primates from Kenya. | In Kenya, Leishmania major is responsible for human cutaneous leishmaniasis (CL). Natural infection with L. major of a vervet monkey and experimental susceptibility of some nonhuman primates (NHPs) from Kenya has been established. However, there has been no comprehensive study of the prevalence of zoonotic CL in Kenya.... | 18,983,806 |
Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery. | The epithelial and endothelial barriers of the human body are major obstacles for drug delivery to the systemic circulation and to organs with unique environment and homeostasis, like the central nervous system. Several transport routes exist in these barriers, which potentially can be exploited for enhancing drug perm... | 18,983,815 |
Bisnaphthalimidopropyl spermidine induces apoptosis within colon carcinoma cells. | Bisnaphthalimido compounds bisintercalate to DNA via the major groove and are potentially potent cancer therapeutics. We incorporated natural polyamines as linkers connecting the two-naphthalimido ring moieties to create a series of novel soluble cytotoxic bisnaphthalimidopropyl polyamines (BNIPPs). Here, we determined... | 18,983,836 |
Paclitaxel-octreotide conjugates in tumor growth inhibition of A549 human non-small cell lung cancer xenografted into nude mice. | Targeted chemotherapy is a novel approach to cancer therapies. This study evaluated the anti-tumor effects of conjugates made by coupling cytotoxic paclitaxel to the somatostatin analog octreotide in A549 human non-small-cell lung cancer (NSCLC) cells xenografted into nude mice. Two cytotoxic somatostatin analogs, pacl... | 18,983,839 |
Unfolding thermodynamics of the Delta-domain in the prohead I subunit of phage HK97: determination by factor analysis of Raman spectra. | An early step in the morphogenesis of the double-stranded DNA (dsDNA) bacteriophage HK97 is the assembly of a precursor shell (prohead I) from 420 copies of a 384-residue subunit (gp5). Although formation of prohead I requires direct participation of gp5 residues 2-103 (Delta-domain), this domain is eliminated by viral... | 18,983,851 |
Testing a counter-intuitive prediction of optimal cue combination. | Weighted averaging is said to be optimal when the weights assigned to the cues minimize the variance of the final estimate. Since the variance of this optimal percept only depends on the variances of the individual cues, irrespective of their values, judgments about a cue conflict stimulus should have the same variance... | 18,983,869 |
Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors. | The heptad repeats (HR1 and HR2) of the spike protein of SARS-CoV are highly conserved regions forming a critical 6-helix bundle during the fusion step of virus entry and are attractive targets of entry inhibitors. In this study, we report that a minimal HR2 peptide, P6 of 23-mer, can block the fusion of SARS-CoV with ... | 18,983,873 |
Pre-surgical training ameliorates orbitofrontal-mediated impairments in spatial reversal learning. | We recently reported that orbitofrontal cortical (OFC) lesions impaired reversal learning of an instrumental two-lever spatial discrimination task, a deficit manifested as increased perseveration on the pre-potent response. Here we examine whether exposure to reversal learning test pre-operatively may have a beneficial... | 18,983,877 |
Neem leaf glycoprotein directs T-bet-associated type 1 immune commitment. | Neem leaf glycoprotein (NLGP)-mediated immune activation and associated immune polarization was studied. NLGP-induced activation is reflected in upregulation of early activation marker CD69 on lymphocytes, monocytes, and dendritic cells. Activation is also denoted by CD45RO enhancement, with a decrease in CD45RA phenot... | 18,983,881 |
The mechanism of vasorelaxation induced by Schisandra chinensis extract in rat thoracic aorta. | Schisandra chinensis (SC) is a known medical herb for the treatment of cardiovascular symptoms associated with menopausal symptoms in Korea. However, the pharmacological action mechanisms involved have not been well studied. This study was aimed to investigate the vascular effects of SC in rat thoracic aorta. We isolat... | 18,983,904 |
Aggregation of Escherichia coli proteins during stationary phase depends on glucose and oxygen availability. | In natural environments, bacteria are often challenged by nutrient starvation and other stresses. As a consequence, cell growth is arrested and bacteria enter stationary phase. In this report, we demonstrate that during stationary phase, Escherichia coli cells accumulate aggregates of misfolded proteins and complexes o... | 18,983,914 |
Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease. | The airway inflammation of chronic obstructive pulmonary disease (COPD) demonstrates a poor response to the anti-inflammatory actions of corticosteroids. However, long-acting beta(2)-agonists and low-dose theophylline are reported to have a possible anti-inflammatory effect in COPD. The aim of this study was to compare... | 18,983,928 |
Field preservation of monogenean parasites for molecular and morphological analyses. | In the present work we examined the efficacy of three different chemical solutions (EtOH 70%, DMSO-NaCl solution, and Longmire buffer) in field preservation of fish gills to be subsequently screened for monogenean specimens destined to morphological and molecular analyses. Degree of difficulty in collecting monogeneans... | 18,983,938 |
Cyclin-dependent kinase-5 targeting for ischaemic stroke. | Recovery from ischaemic stroke is dependent on survival of neurones, particularly in peri-infarcted regions. Angiogenesis is critical for the development of new microvessels resulting in the re-formation of collateral circulation associated with enhanced neuronal survival and reduced morbidity and mortality. Recently, ... | 18,983,942 |
SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate. | Small ubiquitin-like modifier 1 (SUMO1) haploinsufficiency results in cleft lip and palate in animal models. However, no studies have linked SUMO1 to non-syndromic cleft lip with or without cleft palate (NSCLP) in humans. In the present study, we investigated the potential association between SUMO1 single nucleotide po... | 18,983,974 |
Chinese hamster monomeric carbonyl reductases of the short-chain dehydrogenase/reductase superfamily. | Chinese hamster monomeric carbonyl reductases (CHCRs) belong to the short-chain dehydrogenase/reductase (SDR) superfamily, which is a family of enzymes that metabolize many endogenous and xenobiotic compounds. We previously cloned three carbonyl reductase cDNAs-Chcr1, Chcr2, and Chcr3. By performing spectrophotometric ... | 18,983,989 |
Free radical fragmentation of cardiolipin by cytochrome c. | The effect of cytochrome c (cyt c) on degradation of cardiolipin in its polar part was investigated in cardiolipin/phosphatidylcholine (CL/PC) liposomes incubated with cyt c/H(2)O(2)/and (or) ascorbate by high-performance thin layer chromatography and MALDI-TOF mass spectrometry. It has been shown that phosphatidic aci... | 18,983,994 |
Altering the regioselectivity of the subterminal fatty acid hydroxylase P450 BM-3 towards gamma- and delta-positions. | Cytochrome P450 BM-3 monooxygenase from Bacillus megaterium (CYP102A1) catalyzes the subterminal hydroxylation of fatty acids with a chain length of 12-22 carbons. Wild-type P450 BM-3 oxidizes saturated fatty acids at subterminal positions producing a mixture of omega-1, omega-2 and omega-3 hydroxylated products. Using... | 18,984,016 |
Differences in the injury/sprouting response of splenic noradrenergic nerves in Lewis rats with adjuvant-induced arthritis compared with rats treated with 6-hydroxydopamine. | Sympathetic nerves in the spleen undergo an injury and sprouting response with development of adjuvant-induced arthritis (AA), a model of rheumatoid arthritis (RA). The objective of the present study was to determine whether this injury and sprouting response is disease-specific or occurs in a non-specific manner simil... | 18,984,038 |
Regulation of somatic firing dynamics by backpropagating dendritic spikes. | Pyramidal cells of the apteronotid ELL have been shown to display a characteristic mechanism of burst discharge, which has been shown to play an important role in sensory coding. This form of bursting depends on a reciprocal dendro-somatic interaction, in which discharge of a somatic spike causes a dendritic spike, whi... | 18,984,047 |
Discussion: 'Hypnotic analgesia during first-trimester termination' by Marc et al. | In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed: Marc I, Rainville P, Masse B, et al. Hypnotic analgesia intervention during first-trimester pregnancy termination... | 18,984,071 |
Infrared endoscopic system for bleeding-point detection after flushing with indocyanine green solution (with videos). | Infrared endoscopy is used to visualize vessels in the GI tract. By applying this system, we developed a new method to visualize a bleeding point during endoscopic resection. This study aimed to evaluate the ability of infrared endoscopy to detect a bleeding point during endoscopic resection and to elucidate the mechan... | 18,984,104 |
Treatment of a completely obstructed colonic anastomotic stricture by using a prototype forward-array echoendoscope and facilitated by SpyGlass (with videos). | Colonic anastomotic strictures complicate colorectal resection in up to 7% of cases and are often managed with endoscopic dilation. Complete anastomotic obstructions are rare and have traditionally required surgical remediation. To demonstrate a novel endoscopic approach to treat complete colonic anastomotic obstructio... | 18,984,106 |
[Paraplegia after interlaminar epidural steroid injection: a case report]. | We report the first case of paraplegia observed after epidural steroid injection in the upper spine. The patient was a 42-year-old male who underwent surgery two years earlier for stenosis of the lumbar spine from L2 to the sacrum leading to early manifestations of an equina cauda syndrome. This first operation provide... | 18,984,128 |
It takes a (dysfunctional) village to raise a tumor. | The tumor microenvironment is known to play an important role in tumorigenesis. In this issue, Yang et al. (2008) demonstrate that mast cells heterozygous for the Nf1 gene promote the growth of neurofibromas in a mouse model of neurofibromatosis and that genetic and pharmacological inhibition of these cells is sufficie... | 18,984,150 |
The MatP/matS site-specific system organizes the terminus region of the E. coli chromosome into a macrodomain. | The organization of the Escherichia coli chromosome into insulated macrodomains influences the segregation of sister chromatids and the mobility of chromosomal DNA. Here, we report that organization of the Terminus region (Ter) into a macrodomain relies on the presence of a 13 bp motif called matS repeated 23 times in ... | 18,984,159 |
Clinical characteristics of external auditory canal cholesteatoma in children. | The purpose of this study was to investigate the characteristics of pediatric external auditory canal cholesteatoma (EACC). Chart review of nine children with EACC between January 1, 2000 and December 31, 2007 was performed with subsequent analysis of etiologic factors, associated symptoms, otoscopic findings, imaging ... | 18,984,260 |
Relationship between voice quality and vocal nodule size. | To determine the effect of vocal nodule size on voice in pediatric patients. Vocal nodules were graded according to a validated grading scale by three pediatric otolaryngologists. Patients evaluated from 2003 to 2007 with a diagnosis of vocal nodules were included. Forty patients (21 female) with a mean age of 7.5 year... | 18,984,271 |
Foreign-body reaction to the Artelon CMC joint spacer: case report. | The Artelon CMC spacer (Small Bone Innovations, Inc., Morrisville, PA) is a relatively new device that was developed for the treatment of basal joint arthritis. It is composed of a biodegradable polycaprolactone-based polyurethane urea that acts to resurface the distal part of the trapezium and stabilize the trapeziome... | 18,984,346 |
Chronic Mycobacterium infection of first dorsal web space after accidental Bacilli Calmette-Guérin injection in a health worker: case report. | We present a case of inoculation of the first dorsal web space by a nurse practitioner who accidentally stuck herself while preparing Bacilli Calmette-Guérin vaccine for treatment of bladder tumor. We report the evolution and management of this resistant chronic Mycobacterium infection that ultimately required use of a... | 18,984,347 |
Clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: a status report. | This article reviews the anti-inflammatory and nonantimicrobial effects of antibiotics in acne and other diseases and examines issues relating to the emergence of decreased bacterial sensitivity to antibiotics and how these issues relate to clinical practice. It includes an overview of the inflammatory activities of so... | 18,984,363 |
Use of antibiotics for noninfectious dermatologic disorders. | One fascinating element of medical dermatology is the diversity of available therapeutic agents, and dermatologists are well versed in applying the mechanism of action of a drug to modify a disease process. Oral antibiotics are the ideal example of pharmacologic agents that are effective against inflammatory processes ... | 18,984,371 |
Medical management of hip fracture. | The United States population at the greatest risk for hip fracture, those aged 65 years and older, is steadily increasing in size. Today, the incidence of hip fracture is approximately 250,000 per year and it is expected to double in the next 30 years. Hip fracture patients are comorbid at baseline, and there are compl... | 18,984,382 |
Impact of orthodontic appliances on sleep quality. | Many young patients are asked to wear headgear or functional appliances during sleep as part of their orthodontic treatment. The objective of this clinical study was to assess the impact of these appliances on sleep quality. Twenty-two subjects (8 boys, 14 girls) between 10 and 15 years of age wearing either a headgear... | 18,984,392 |
Comparison of treatment outcomes between skeletal anchorage and extraoral anchorage in adults with maxillary dentoalveolar protrusion. | The goal of this retrospective cephalometric study was to compare orthodontic outcomes in patients with maxillary dentoalveolar protrusion malocclusion treated with extraoral headgear or mini-implants for maximum anchorage. Forty-seven subjects with Angle Class II malocclusion or Class I bimaxillary dentoalveolar protr... | 18,984,393 |
Bicortical vs monocortical orthodontic skeletal anchorage. | Case reports have documented the use of titanium miniscrews in providing skeletal anchorage for orthodontic tooth movement. Success rates as low as 50% have been reported for screw retention in either the facial or the lingual cortical plates (monocortical placement). The purpose of this in-vitro study was to test the ... | 18,984,394 |
Gingival recession in young adults: occurrence, severity, and relationship to past orthodontic treatment and oral piercing. | Gingival recession can be localized or generalized and associated with at least 1 tooth surface. As a result, gingival recession leads to root surface exposure, often causing esthetic impairment, fear of tooth loss, increased susceptibility for root caries, and dentin hypersensitivity. The prevalence, extent, and sever... | 18,984,397 |
Growth and development of the cranial base in mice that spontaneously develop anterior transverse crossbite. | Homozygous brachymorphic (bm/bm) mice are characterized by disproportionately short stature. Anterior transverse crossbite sometimes develops spontaneously in inbred BALB/c-bm/bm mice that produce undersulfated glycosaminoglycans. The reason for inferior growth of the craniofacial structures of BALB/c-bm/bm mice has no... | 18,984,401 |
Orthodontics in 3 millennia. Chapter 15: Skeletal anchorage. | For many years, orthodontists have searched for a form of anchorage that does not rely on patient cooperation, although the answer already lay in the implants dentists used to replace missing teeth and oral surgeons used to hold bone segments together. Now these divergent lines have come together in the form of station... | 18,984,405 |
Role of nuclear scintigraphy in the characterization and management of the salivary component of Sjögren's syndrome. | The American-European Consensus Group, in its classification criteria of Sjögren's syndrome (SS), consigns dynamic salivary scintigraphy to providing objective evidence of xerostomia, a secondary role. In the current SS therapeutic environment, scintigraphy's ability to differentiate parenchymal damage from neuropathic... | 18,984,416 |
A risk score to predict intracranial hemorrhage after recombinant tissue plasminogen activator for acute ischemic stroke. | Ability to predict risk of postthrombolysis intracerebral hemorrhage (ICH) is currently limited. Using data from the Multicenter Recombinant Tissue Plasminogen Activator Stroke Survey Group, we developed a score to predict this risk. One point was assigned for the presence of each of 4 variables: age older than 60 year... | 18,984,422 |
The effects of study participation in the Familial Intracranial Aneurysm Study on cigarette smoking. | Cigarette smoking is the most modifiable risk factor for the formation and rupture of intracranial aneurysm (IA). This study examined the impact of participation in the Familial IA study on smoking behavior. On entry into the study, a baseline smoking history was obtained. At follow-up visits, subjects were surveyed co... | 18,984,429 |
Asymptomatic large T2 high-signal pontine lesions that are different from ischemic rarefaction. | We encountered asymptomatic large T2 high-signal pontine lesion (PL) with peachlike configurations on magnetic resonance imaging. The objective of this study was to determine the pathogenic factors for such PLs and to differentiate PL from ischemic rarefaction. We compared the clinical backgrounds of 37 patients with P... | 18,984,434 |
Erectile dysfunction as a coronary artery disease risk equivalent. | The conditions that predispose patients to erectile dysfunction are substantially similar to the coronary artery disease risk factors, including diabetes mellitus, hypertension, hyperlipidemia, obesity, sedentary lifestyle, depression, age, and smoking. Because of these shared risks and overlapping pathophysiologic mec... | 18,984,455 |
PET detection of the impact of dobutamine on myocardial glucose metabolism in women with type 1 diabetes mellitus. | Our objective was to determine, in the hearts of women with type 1 diabetes mellitus (T1DM), whether the fate of extracted glucose is altered and, if so, what the impact of dobutamine is on myocardial substrate metabolism. In experimental models of T1DM, myocardial glycolysis and glucose oxidation are reduced with the ... | 18,984,454 |
Noninvasive assessment of liver fibrosis: serum markers, imaging, and other modalities. | Liver fibrosis is a common pathway of injury after chronic insult to the liver. The evolution of liver fibrosis to cirrhosis has many clinical implications, including bleeding, infection, hepatocellular carcinoma, and death. The reference standard for diagnosing liver fibrosis is currently histologic assessment of tiss... | 18,984,472 |
Current and future anti-fibrotic therapies for chronic liver disease. | Chronic injury results in a wound healing response that eventually leads to fibrosis. The response is generalized, with features common among multiple organ systems. In the liver, various different types of injury lead to fibrogenesis, implying a common pathogenesis. Although several specific therapies for patients who... | 18,984,475 |
Imported infectious diseases and surveillance in Japan. | Surveillance of imported infectious diseases is important because of the need for early detection of outbreaks of international concern as well as information of risk to the travelers. This paper attempts to review how the Japanese surveillance system deals with imported infectious diseases and reviews the trend of the... | 18,984,479 |
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