title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier. | One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its ad... | 18,980,322 |
A method for cleaving an allyl protecting group at the amide nitrogen of peptides by one-pot olefin isomerization-oxidation. | A facile method for N-deallylation at the amide nitrogen of peptides is described. One-pot deallylation of a substrate through ruthenium hydride-catalyzed terminal olefin isomerization and subsequent ozonolysis gave the corresponding deallylated product under mild conditions. | 18,980,332 |
Neutron scattering study of the structural change induced by photopolymerization of AOT/D2O/dodecyl acrylate inverse microemulsions. | Small-angle and ultrasmall-angle neutron scattering (SANS/USANS) measurements were used to determine the structural changes induced by photopolymerization of AOT/D2O/(dodecyl acrylate) inverse microemulsion systems. Scattering profiles were collected for the initial microemulsions and the films resulting from photopoly... | 18,980,349 |
PAMAM dendrimer interactions with supported lipid bilayers: a kinetic and mechanistic investigation. | The interaction kinetics of polyamidoamine (PAMAM) dendrimers with supported lipid bilayers of 1,2-sn-glycero-dimyristoylphosphocholine prepared by the vesicle deposition has been probed by optical waveguide lightmode spectroscopy and atomic force microscopy (AFM). In particular, the influence of PAMAM dendrimer genera... | 18,980,350 |
Structure of molybdenum and tungsten sulfide M(x)S(y)+ clusters: experiment and DFT calculations. | A combination of experiment and density functional theory was used to investigate the energetics of CO adsorption onto several small M(x)S(y)(+) (M = Mo, W; x/y = 2/6, 3/7, 5/7, 6/8) clusters as a probe of their atomic and electronic structure. Experimentally, tandem mass spectrometry was used to measure the relative y... | 18,980,366 |
Synthesis of chiral organocatalysts derived from aziridines: application in asymmetric aldol reaction. | We report the synthesis of a new series of highly efficient chiral organocatalysts derived via the regio- and stereoselective ring opening of chiral aziridines with azide anions. The catalysts have proved to be very efficient for a direct asymmetric aldol reaction, both with cyclic as well as acyclic ketones in brine w... | 18,980,379 |
Comparison of water, sediment, and plants for the monitoring of antibiotics: a case study on a river dedicated to fish farming. | Oxolinic acid, flumequine, oxytetracycline, and florfenicol are antibiotics commonly used in farming. Because an important percentage of these antibiotics given to fish and cattle ends up, directly or indirectly, in the freshwater environment, suitable tools for the monitoring of these antibiotics are needed. A French ... | 18,980,393 |
CARIN theory reanalysis reanalyzed: a comment on Maguire, Devereux, Costello, and Cater (2007). | P. Maguire, B. Devereux, F. Costello, and A. Cater discussed the Gagné and Shoben (1997) CARIN theory of conceptual combination and, after presenting a sample drawn from the British National Corpus and comparing the two corpora, concluded that the Gagné and Shoben corpus is too small and unrepresentative. They then dis... | 18,980,417 |
Assessment of platelet growth factors in supernatants from rehydrated freeze-dried equine platelets and their effects on fibroblasts in vitro. | To determine whether platelet growth factors are preserved in supernatants obtained from rehydrated trehalose-stabilized, freeze-dried (lyophilized) equine platelets and whether those growth factors stimulate fibroblast proliferation and migration and enhance fibroblast-associated contraction in a collagen gel assay. 6... | 18,980,435 |
Retrospective evaluation of the effects of diazepam in dogs with anxiety-related behavior problems. | To characterize the effects of diazepam in dogs with behavior problems and to determine whether adverse effects were of sufficient concern to owners to prompt drug discontinuation. Cross-sectional study. 37 dogs and their owners. Dogs for which diazepam had been prescribed by the behavior service of a veterinary teachi... | 18,980,494 |
Factors associated with survival of neonatal foals with bacteremia and racing performance of surviving Thoroughbreds: 423 cases (1982-2007). | To identify factors associated with short-term survival in bacteremic neonatal foals, evaluate the racing performance of Thoroughbred survivors, and evaluate changes in causative organisms and their antimicrobial susceptibility. Retrospective case series. 423 bacteremic foals. Medical records of foals that were hospita... | 18,980,499 |
Lipopolysaccharide-mediated enhancement of bone metabolism in estrogen-deficient mice. | Osteoporosis may be a risk factor in periodontal disease. However, biologic mechanisms explaining the apparent interaction between these two diseases have not been defined. It is well known that lipopolysaccharide (LPS) increases the resorption of alveolar bone. We hypothesized that LPS and estrogen deficiency have syn... | 18,980,527 |
Pay for performance programs in Australia: a need for guiding principles. | Pay-for-performance (P4P) programs which reward clinical providers with incentive payments based on one or more measures of quality of care are now common in the United States and the United Kingdom and it is likely they will attract increasing interest in Australia. However, empirical evidence demonstrating effectiven... | 18,980,570 |
A case study of centralised monitoring of hospital access performance. | Access to care for patients remains a concern for all parties in the provision of hospital services. It is the subject of patient complaints, large investments of funds and vigorous debate in the community, hospitals and the political arena. This is a common problem in developed nations. There has been little achieveme... | 18,980,571 |
A decade of data linkage in Western Australia: strategic design, applications and benefits of the WA data linkage system. | The report describes the strategic design, steps to full implementation and outcomes achieved by the Western Australian Data Linkage System (WADLS), instigated in 1995 to link up to 40 years of data from over 30 collections for an historical population of 3.7 million. Staged development has seen its expansion, initiall... | 18,980,573 |
Quality frameworks for telephone triage. | The establishment of the Grampians After-Hours Service has led to the development of a quality framework for nurse telephone triage. The service providers believe this framework is the basis for the service's success. While quality frameworks including critical evaluation and peer review are not new to the health indus... | 18,980,575 |
Oxysterol activation of phosphatidylcholine synthesis involves CTP:phosphocholine cytidylyltransferase alpha translocation to the nuclear envelope. | In addition to suppressing cholesterol synthesis and uptake, oxysterols also activate glycerophospholipid and SM (sphingomyelin) synthesis, possibly to buffer cells from excess sterol accumulation. In the present study, we investigated the effects of oxysterols on the CDP-choline pathway for PtdCho (phosphatidylcholine... | 18,980,580 |
How stable is sense of coherence? Changes following an intervention for unemployed individuals. | The present investigation was concerned with the changeability of sense of coherence. We examined changes in sense of coherence (SOC) over a six-month period in a sample of Finnish unemployed individuals (n = 74) participating in an intervention program designed to boost re-employment. Over the study period, participan... | 18,980,600 |
Long-term in vitro reactivity for human leukocyte antigen antibodies and comparison of detection using serum versus plasma. | Human leukocyte antigen (HLA) antibodies are a possible cause of transfusion-related acute lung injury (TRALI), and fluorescent bead assays are often used for antibody detection. Serum is the manufacturer's recommended sample, but plasma may be easier to obtain for studies of HLA antibody prevalence and TRALI case inve... | 18,980,615 |
Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective. | Several factors acting together have recently enabled clinicians to seriously consider whether chronic immunosuppression is needed in all solid organ allograft recipients. This has prompted a dozen or so centers throughout the world to prospectively wean immunosuppression from conventionally treated liver allograft rec... | 18,980,624 |
Independent evolution of functional Pm3 resistance genes in wild tetraploid wheat and domesticated bread wheat. | The Pm3 alleles of cultivated bread wheat confer gene for gene resistance to the powdery mildew fungus. They represent a particular case of plant disease resistance gene evolution, because of their recent origin and possible evolution after the formation of hexaploid wheat. The Pm3 locus is conserved in tetraploid whea... | 18,980,638 |
A toolbox and procedural notes for characterizing novel zinc finger nucleases for genome editing in plant cells. | The induction of double-strand breaks (DSBs) in plant genomes can lead to increased homologous recombination or site-specific mutagenesis at the repair site. This phenomenon has the potential for use in gene targeting applications in plant cells upon the induction of site-specific genomic DSBs using zinc finger nucleas... | 18,980,651 |
HvLsi1 is a silicon influx transporter in barley. | Most plants accumulate silicon in their bodies, and this is thought to be important for resistance against biotic and abiotic stresses; however, the molecular mechanisms for Si uptake and accumulation are poorly understood. Here, we describe an Si influx transporter, HvLsi1, in barley. This protein is homologous to ric... | 18,980,663 |
Learning transcriptional regulatory networks from high throughput gene expression data using continuous three-way mutual information. | Probability based statistical learning methods such as mutual information and Bayesian networks have emerged as a major category of tools for reverse engineering mechanistic relationships from quantitative biological data. In this work we introduce a new statistical learning strategy, MI3 that addresses three common is... | 18,980,677 |
mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft. | Interactions between the gene products encoded by the mitochondrial and nuclear genomes play critical roles in eukaryotic cellular function. However, the effects mitochondrial DNA (mtDNA) levels have on the nuclear transcriptome have not been defined under physiological conditions. In order to address this issue, we ch... | 18,980,691 |
Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients. | Coeliac disease (CD) is an enteropathy characterized by an aberrant immune response to cereal-gluten proteins. Although gluten peptides and microorganisms activate similar pro-inflammatory pathways, the role the intestinal microbiota may play in this disorder is unknown. The purpose of this study was to assess whether ... | 18,980,693 |
Genetic noise control via protein oligomerization. | Gene expression in a cell entails random reaction events occurring over disparate time scales. Thus, molecular noise that often results in phenotypic and population-dynamic consequences sets a fundamental limit to biochemical signaling. While there have been numerous studies correlating the architecture of cellular rea... | 18,980,697 |
Spontaneous transformation of human granulosa cell tumours into an aggressive phenotype: a metastasis model cell line. | Granulosa cell tumours (GCTs) are frequently seen in menopausal women and are relatively indolent. Although the physiological properties of normal granulosa cells have been studied extensively, little is known about the molecular mechanism of GCT progression. Here, we characterise the unique behavioural properties of a... | 18,980,698 |
Recent advances in understanding depression in adults with diabetes. | The authors review the science linking depression with diabetes. Some recent heuristic research is identified that highlights progress in the field and is directing future research. Issues in the management of depression in diabetes are outlined, including interactions of depression and insulin resistance. | 18,980,733 |
[Bioenergy production from waste: examples of biomethane and biohydrogen]. | This new century addresses several environmental challenges among which distribution of drinking water, global warming and availability of novel renewable energy sources to substitute for fossil fuels are of utmost importance. The last two concerns are closely related because the major part of carbon dioxide (CO(2)), c... | 18,980,740 |
[Postgenomic analysis of desiccation tolerance]. | Desiccation tolerance is the capacity to survive complete drying. It is an ancient trait that can be found in prokaryotes, fungi, primitive animals (often at the larval stages), whole plants, pollens and seeds. In the dry state, metabolism is suspended and the duration that anhydrobiotes can survive ranges from years t... | 18,980,743 |
Clinical and biochemical presentations of polycystic ovary syndrome among obese and nonobese women. | To study the differences in clinical and biochemical characteristics between obese and nonobese women with polycystic ovary syndrome (PCOS). Retrospective study. University teaching hospital. Four hundred sixty-four Taiwan Chinese women, among whom 295 were diagnosed with PCOS and 169 were non-PCOS controls. Body mass ... | 18,980,763 |
The influence of disinfection on aquatic biodegradable organic carbon formation. | The aim of this paper was to assess the extent of biodegradable dissolved organic carbon formation upon disinfection of water with chlorine dioxide. Wide diversity of natural waters has been subjected to reactions with various amounts of ClO(2). For comparison examined waters have also been treated with ozone and chlor... | 18,980,774 |
RNA polymerases I and III, non-coding RNAs and cancer. | Oncogenically transformed cells overexpress the non-coding RNAs, such as pre-ribosomal RNA (rRNA) and transfer RNA (tRNA), which are produced by RNA polymerases (Pols) I and III. Recent results indicate that levels of pre-rRNA have prognostic value and that a tRNA has oncogenic potential. Transcription by Pols I and II... | 18,980,784 |
Examination of femoral-neck structure using finite element model and bone mineral density using dual-energy X-ray absorptiometry. | Research regarding femoral-neck fractures has mainly focused on bone mineral density and limited studies have been performed on relationship between the femoral-neck structure and its fracture. Finite element models were established to estimate stress distributions across the femoral neck with various femoral-neck angl... | 18,980,785 |
MRI documented acute myelitis in a patient with Vogt-Koyanagi-Harada syndrome: first report. | MRI findings in transverse myelitis complicating Vogt-Koyanagi-Harada (VKH) syndrome have not been documented before. Here, we present a case with acute myelitis complicating VKH syndrome and show the MRI findings. | 18,980,794 |
Analytical methodologies for the determination of sertraline. | Sertraline is a widely used antidepressant belonging to the selective serotonin reuptake inhibitor class; its efficacy has been demonstrated not only in the treatment of major depression, obsessive compulsive and panic disorders, but also for eating, premenstrual dysphoric and post-traumatic stress disorders. Several m... | 18,980,823 |
Chorioallantoic membrane assays have been based on diffusion control--problems arising with a diversity of mass transfers in egg white. | The chorioallantoic membrane (CAM) assays have been intensively used to determine angiogenesis and anti-angiogenesis of medicines. In view of bioactivity, this technique should be performed with kinetic control regime in chicken embryos. Whether the dosages ever used had satisfied this requirement, we explored by mathe... | 18,980,833 |
Polymerizing immobilization of acrylamide-modified nucleic acids and its application. | The immobilization of nucleic acids on solid supports has been widely used in the detection of DNA and other biomolecules in sensor technology. Because three dimensional (3-D) hydrogel matrixes offer significant advantages for capturing probes over more conventional two dimensional (2-D) rigid substrates and the abilit... | 18,980,839 |
Sternoclavicular septic arthritis in a previously healthy patient: a case report and review of the literature. | Sternoclavicular septic arthritis is an unusual event in healthy patients. Cases have been reported in diabetes mellitus patients, intravenous drug abusers and patients affected by rheumatoid arthritis. We report a case of this unique infection that occurred in a patient who was not at risk of septic arthritis. Through... | 18,980,853 |
Dissociating nociceptive modulation by the duration of pain anticipation from unpredictability in the timing of pain. | Waiting longer to receive pain increases its perceived unpleasantness by inducing 'dread'. However, it is not clear how unpredictability in the timing of the impending pain stimulus interacts with dread and whether the two factors show differential effects on the neural generators of the pain-evoked response. We manipu... | 18,980,863 |
Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies. | A bioanalytical method for the analysis of artesunate (ARS) and its metabolite dihydroartemisinin (DHA) in human plasma using protein precipitation and liquid chromatography coupled to positive tandem mass spectroscopy was developed. The method was validated according to published US FDA-guidelines and showed excellent... | 18,980,865 |
Willingness among college students to help a smoker quit. | Between February and March 2003, the authors examined college students' willingness to help a smoker quit and assessed demographic and psychosocial characteristics associated with willingness to help. Survey respondents were 701 college students (474 women, 227 men) aged 18 to 24 years who indicated there was someone c... | 18,980,882 |
The use of nutritional labels by college students in a food-court setting. | Between January and September 2006, the authors examined when, why, if, and how nutrition labels impact food purchase decisions of college students. Participants were 16 college-aged students at a large northeastern university. As part of a larger study undertaken at a large northeastern university on the effect of nut... | 18,980,885 |
Readiness to change among a group of heavy-drinking college students: correlates of readiness and a comparison of measures. | Although several multi-item scales assess readiness to change alcohol consumption, some researchers have proposed that a small number of single-item rulers may assess readiness nearly as well. In fall 2006 and spring 2007, the authors assessed 279 participants who reported at least 1 heavy drinking episode in the 2 wee... | 18,980,889 |
Risk of unwanted sex for college women: evidence for a red zone. | University and college health and counseling centers frequently warn female students about the red zone-a period early in a student's first year at college during which she may be at higher risk for unwanted sexual experiences (UWS). The authors designed this study to assess temporal risk for UWS in 1st- and 2nd-year c... | 18,980,890 |
The role of haptic exploration of ground surface information in perception of overhead reachability. | The authors performed an experiment in which participants (N = 24) made judgments about maximum jump and reachability on ground surfaces with different elastic properties: sand and a trampoline. Participants performed judgments in two conditions: (a) while standing and after having recently jumped on the surface in que... | 18,980,903 |
The experience of imagery as a post-treatment intervention in patients with breast cancer: program, process, and patient recommendations. | To better understand the common themes of women participating in an imagery program designed to improve quality of life (QOL). Qualitative. Classroom setting at Alaska Regional Hospital in Anchorage. 10 women with a confirmed diagnosis of breast cancer who had completed conventional care participated in a six-class, ei... | 18,980,915 |
Effects of a supervised exercise intervention on recovery from treatment regimens in breast cancer survivors. | To investigate the effects of supervised exercise training on cardiopulmonary function and fatigue in cancer survivors undergoing various clinical treatments. Pretest and post-test quasiexperimental. Outpatient oncology rehabilitation center. 96 breast cancer survivors undergoing various clinical treatments. Subjects w... | 18,980,921 |
Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8. | Palmitoylation is a posttranslational modification that regulates protein trafficking and stability. In this study we investigated whether the endosomal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) proteins syntaxin 7 and syntaxin 8 are modified with palmitate. Using metabolic labeling... | 18,980,942 |
Corresponding increase in long-chain acyl-CoA and acylcarnitine after exercise in muscle from VLCAD mice. | Long-chain acylcarnitines accumulate in long-chain fatty acid oxidation defects, especially during periods of increased energy demand from fat. To test whether this increase in long-chain acylcarnitines in very long-chain acyl-CoA dehydrogenase (VLCAD(-/-)) knock-out mice correlates with acyl-CoA content, we subjected ... | 18,980,943 |
Deep venous thrombosis caused by congenital malformation of the inferior vena cava and heterozygous factor V leiden presenting as venous claudication. | A case of an 18-year-old man with deep venous thrombosis of the lower limbs caused by hypoplasia of the inferior vena cava in combination with heterozygous factor V Leiden is presented. Both anomalies were found when the patient complained of venous claudication in both thighs. Inferior vena cava malformation is a rare... | 18,980,946 |
BRCA1 5083del19 mutant allele selectively up-regulates periostin expression in vitro and in vivo. | The aim of this study was to explore the gene expression pattern produced by the cancer-associated BRCA1 5083del19 founder mutation by using a microarray analysis. Such a mutation, identified in a subset of familial breast cancer patients, involves a deletion at the 3' end of the BRCA1 messenger leading, in the mature ... | 18,980,973 |
Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis. | The purpose of this study was to examine the molecular mechanisms by which sulforaphane enhances the therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in prostate cancer. Cell viability and apoptosis assays were done by XTT and terminal deoxynucleotidyl transferase-mediated dUTP n... | 18,980,980 |
Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas. | Although patients with newly diagnosed WHO grade 3 malignant glioma have a more favorable prognosis than those with WHO grade 4 malignant glioma, salvage therapies following recurrence offer essentially palliative benefit. We did a phase II trial of bevacizumab, a monoclonal antibody to vascular endothelial growth fact... | 18,981,004 |
Population pharmacokinetics and pharmacogenetics of imatinib in children and adults. | The aim of this study was to explore the effect of several demographic, biological, and pharmacogenetic covariates on the disposition of imatinib and its main metabolite (CGP74588) in both adults and children. Thirty-three children with solid malignancies included in a phase II exploratory study and 34 adults with gast... | 18,981,009 |
A meta-analysis of impact exercise on postmenopausal bone loss: the case for mixed loading exercise programmes. | To assess the effects of differing impact exercise protocols on postmenopausal bone loss at the hip and spine. Systematic review and meta-analysis. Electronic bibliographic databases, key journals and reference lists of reviews and articles. Two independent reviewers assessed controlled trials evaluating effects of imp... | 18,981,037 |
Experimental antibody therapy of liver metastases reveals functional redundancy between Fc gammaRI and Fc gammaRIV. | Many patients with colorectal cancer will develop liver metastases, even after successful surgical removal of the primary tumor at a time at which no visible metastases are present. We previously demonstrated that surgery--although mandatory--paradoxically enhances the risk of developing liver metastases. Because Ab th... | 18,981,101 |
Human CD4+ CD25+ Foxp3+ regulatory T cells do not constitutively express IL-35. | EBV-induced gene 3 (EBI3) can associate with p28 to form the heterodimeric cytokine IL-27, or with the p35 subunit of IL-12 to form the EBI3/p35 heterodimer, recently named IL-35. In mice, IL-35 has been shown to be constitutively expressed by CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg cells) and suggested to contr... | 18,981,109 |
A novel role for neutrophils as critical activators of NK cells. | Neutrophils are essential players in innate immune responses to bacterial infection. Despite the striking resistance of Legionella pneumophila (Lpn) to bactericidal neutrophil function, neutrophil granulocytes are important effectors in the resolution of legionellosis. Indeed, mice depleted of neutrophils were unable t... | 18,981,133 |
TNF-alpha is a positive regulatory factor for human Vgamma2 Vdelta2 T cells. | Vgamma2 Vdelta2 T cells in human peripheral blood recognize phosphoantigen and play important roles in host defense and immunoregulation. The TCR is required for Vgamma2 Vdelta2 T cell responses to phosphoantigen, but less is known about soluble or cell-associated costimulatory molecules. In this study, we show that hu... | 18,981,134 |
Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease. | Microglial activation is an important pathological component in brains of patients with Alzheimer's disease (AD), and fibrillar amyloid-beta (Abeta) peptides play an important role in microglial activation in AD. However, mechanisms by which Abeta peptides induce the activation of microglia are poorly understood. The p... | 18,981,147 |
The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function. | The ADP-ribosylation factor-like (Arl) family of small G proteins are involved in the regulation of diverse cellular processes. Arl2 does not appear to be membrane localized and has been implicated as a regulator of microtubule dynamics. The downstream effector for Arl2, Binder of Arl 2 (BART) has no known function but... | 18,981,177 |
Structural and functional analysis of a glycoside hydrolase family 97 enzyme from Bacteroides thetaiotaomicron. | SusB, an 84-kDa alpha-glucoside hydrolase involved in the starch utilization system (sus) of Bacteroides thetaiotaomicron, belongs to glycoside hydrolase (GH) family 97. We have determined the enzymatic characteristics and the crystal structures in free and acarbose-bound form at 1.6A resolution. SusB hydrolyzes the al... | 18,981,178 |
Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling. | MRAP, melanocortin 2 (MC2) receptor accessory protein, is required for trafficking by the MC2 (ACTH) receptor. MRAP is a single transmembrane protein that forms highly unusual antiparallel homodimers. We used molecular complementation to ask where MRAP achieves dual topology. Fragments of yellow fluorescent protein (YF... | 18,981,183 |
Constraint-induced therapy versus dose-matched control intervention to improve motor ability, basic/extended daily functions, and quality of life in stroke. | Trials of constraint-induced movement therapy (CIT) to improve upper extremity function after stroke have usually not included an actively treated control group. This study compared a modified CIT intervention with a dose-matched control intervention that included restraint of the less affected hand and assessed for di... | 18,981,188 |
Endobronchial polyp derived from a myxosarcoma in the lung of a dog. | An endobronchial polyp was visible radiographically and bronchoscopically in an 11-year-old, mixed-breed dog with a persistent cough. The polyp was removed by traction. Initial histological examination suggested it was a myxomatous fibroma. The cough resolved but recurred with polyp regrowth. Two additional lung masses... | 18,981,198 |
Sarcospan reduces dystrophic pathology: stabilization of the utrophin-glycoprotein complex. | Mutations in the dystrophin gene cause Duchenne muscular dystrophy and result in the loss of dystrophin and the entire dystrophin-glycoprotein complex (DGC) from the sarcolemma. We show that sarcospan (SSPN), a unique tetraspanin-like component of the DGC, ameliorates muscular dystrophy in dystrophin-deficient mdx mice... | 18,981,229 |
P bodies promote stress granule assembly in Saccharomyces cerevisiae. | Recent results indicate that nontranslating mRNAs in eukaryotic cells exist in distinct biochemical states that accumulate in P bodies and stress granules, although the nature of interactions between these particles is unknown. We demonstrate in Saccharomyces cerevisiae that RNA granules with similar protein compositio... | 18,981,231 |
A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth. | Mouse-derived macrophages have the unique ability to restrict or permit Legionella pneumophila intracellular growth. The common inbred mouse strain C57BL/6J (B6) restricts L. pneumophila growth, whereas macrophages derived from A/J mice allow >10(3)-fold bacterial growth within three days. This phenotypic difference... | 18,981,241 |
The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection. | The de novo immune response to infectious organisms arises from the innate recognition of pathogen-associated molecular patterns (PAMPs) by the host's pattern recognition receptors (PRRs). As the generation of type 2 cytokine responses by the human trematode parasite Schistosoma mansoni is glycan mediated, there is a p... | 18,981,244 |
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. | In vitro resistance to maribavir (MBV), a cytomegalovirus UL97 kinase inhibitor currently in clinical trials, is known to result from viral UL97 mutations that confer moderate to high-level resistance and UL27 mutations that confer low-level resistance. To add to the four reported UL27 mutations, cytomegalovirus isolat... | 18,981,262 |
Depressive symptoms and serum lipid fractions in middle-aged men: physiologic and health behavior links. | To investigate alternative hypothetical models that could clarify the relationship between depressive symptoms and serum cholesterol fractions, i.e., high-density lipoprotein (HDL) and low-density lipoprotein (LDL). It was hypothesized that the impact of the depressive symptoms on cholesterol fractions is mediated thro... | 18,981,271 |
Home health care and patterns of subsequent VA and medicare health care utilization for veterans. | The Veterans Affairs or VA health care system is in the process of significantly expanding home health care (HHC) nationwide. We describe VA HHC use in 2003 for all VA HHC users from 2002; we examine whether VA utilization across a broad spectrum of services differed for a sample of VA HHC users and their propensity-sc... | 18,981,283 |
Variation in the use of federal and state civil money penalties for nursing homes. | The study examined factors associated with state variations in the use of federal and state civil money penalties (CMPs) for nursing homes. We collected federal and state CMP data from state survey and certification agencies for 2004. We also used federal CMP data from the federal enforcement action database for 2000-2... | 18,981,284 |
Harvest health: translation of the chronic disease self-management program for older African Americans in a senior setting. | We describe the translation of K. R. Lorig and colleagues' Chronic Disease Self-Management Program (CDSMP) for delivery in a senior center and evaluate pre-post benefits for African American participants. Modifications to the CDSMP included a name change; an additional introductory session; and course augmentations inv... | 18,981,286 |
N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. | Inhibition of H(+),K(+)-ATPase is accepted as the most effective way of controlling gastric acid secretion. However, current acid suppressant therapy for gastroesophageal reflux disease, using histamine H(2) receptor antagonists and proton pump inhibitors, does not fully meet the needs of all patients because of their ... | 18,981,288 |
Opportunities and strategies for breast cancer prevention through risk reduction. | Due to the high incidence of breast cancer among US females, risk-reduction strategies are essential. Before considering approaches to breast cancer risk reduction, it is important for clinicians to complete individualized qualitative and quantitative assessments of risk for their patients in order to inform physicians... | 18,981,297 |
Exercise-induced pulmonary arterial hypertension. | The clinical relevance of exercise-induced pulmonary arterial hypertension (PAH) is uncertain, and its existence has never been well studied by direct measurements of central hemodynamics. Using invasive cardiopulmonary exercise testing, we hypothesized that exercise-induced PAH represents a symptomatic stage of PAH, p... | 18,981,305 |
Neurologic manifestations of localized scleroderma: a case report and literature review. | We describe a young woman with localized scleroderma, seizures, numerous persistently enhancing white matter lesions on brain MRI, and oligoclonal bands in the CSF. The case is remarkable in the widespread bilateral distribution of the lesions and their enhancement during more than a year of follow-up despite immunosup... | 18,981,376 |
Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. | Tolerance, described as the loss of drug effectiveness over time, is an important component of addiction. The degree of acute behavioral tolerance to alcohol exhibited by a naïve subject can predict the likelihood of alcohol abuse. Thus, the determinants of acute tolerance are important to understand. Calcium- and volt... | 18,981,408 |
Ceramide starves cells to death by downregulating nutrient transporter proteins. | Ceramide induces cell death in response to many stimuli. Its mechanism of action, however, is not completely understood. Ceramide induces autophagy in mammalian cells maintained in rich media and nutrient permease downregulation in yeast. These observations suggested to us that ceramide might kill mammalian cells by li... | 18,981,422 |
Parathyroid hormone signaling through low-density lipoprotein-related protein 6. | Intermittent administration of PTH stimulates bone formation, but the precise mechanisms responsible for PTH responses in osteoblasts are only incompletely understood. Here we show that binding of PTH to its receptor PTH1R induced association of LRP6, a coreceptor of Wnt, with PTH1R. The formation of the ternary comple... | 18,981,475 |
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression. | During cellular differentiation, both permissive and repressive epigenetic modifications must be negotiated to create cell-type-specific gene expression patterns. The T-box transcription factor family is important in numerous developmental systems ranging from embryogenesis to the differentiation of adult tissues. By a... | 18,981,476 |
Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity. | Genome endoreduplication during mammalian development is a rare event for which the mechanism is unknown. It first appears when fibroblast growth factor 4 (FGF4) deprivation induces differentiation of trophoblast stem (TS) cells into the nonproliferating trophoblast giant (TG) cells required for embryo implantation. He... | 18,981,479 |
Intraspecific evolution of the intercellular signaling network underlying a robust developmental system. | Many biological systems produce an invariant output when faced with stochastic or environmental variation. This robustness of system output to variation affecting the underlying process may allow for "cryptic" genetic evolution within the system without change in output. We studied variation of cell fate patterning of ... | 18,981,482 |
Trypanosoma cruzi transmission cycle among wild and domestic mammals in three areas of orally transmitted Chagas disease outbreaks. | We report Trypanosoma cruzi infection in wild and domestic mammals from three orally acquired Chagas disease outbreak areas in Brazil. Cachoeiro do Arari (Pará) displayed a panzootic scenery (positive mammals in all ecologic strata), and human cases were probably the consequence of their exposure within the sylvatic T.... | 18,981,516 |
Does rooibos tea (Aspalathus linearis) support regeneration of rat liver after intoxication by carbon tetrachloride? | This study evaluates the effect of rooibos tea (RT, Aspalathus linearis) on biochemical and histological parameters during rat liver regeneration after intoxication by carbon tetrachloride (CCl4). From the 10th week, when the administration of CCl4 was terminated, the liver tissue began to regenerate. Seven days later ... | 18,981,533 |
Reducing post-surgical adhesions utilizing a drug-enhanced device: sodium carboxymethylcellulose aqueous gel/poly(p-dioxanone) and Tranilast. | Post-surgical adhesion formation has numerous deleterious side effects in a wide variety of surgical settings. Physical barriers used together with laparoscopy were developed to reduce tissue trauma seen with open procedures. However, despite surgeons' meticulous techniques and the use of such barriers, adhesion format... | 18,981,543 |
Ameliorative effect of Captopril and Valsartan on an animal model of diabetic cardiomyopathy. | The objective of this study was to clarify the relationship between angiotensin II and the pathogenesis of diabetic cardiomyopathy by observing the effects of related drugs on diabetic cardiomyopathy in rats. Captopril and Valsartan, an automatic biochemical analyzer, and radioimmunoassay technology were used to an exp... | 18,981,571 |
Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction. | It was studied to determine if nicorandil can improve frequent urination in rats with partial bladder outlet obstruction (BOO) without changing the blood pressure. Voiding behavior was observed 6 to 8 d after obstruction in female rats with BOO that loaded 30 ml/kg of water. A drug was administered orally. Changes in s... | 18,981,577 |
Active infective endocarditis: management and risk analysis of hospital death from 24 years' experience. | This study was performed to identify risk factors for hospital death in patients with acute and active infective endocarditis (AAIE) after surgical intervention. From 1980 to 2004, 94 patients underwent surgery for AAIE (age range, 3-77 years; 76% males). Congestive heart failure (CHF) was present in 44 patients, as we... | 18,981,596 |
Structures of new monoterpenes from Thai herbal medicine Curcuma comosa. | Three new monoterpenes, comosoxide A (1), comosoxide B (2), and comososide (3), were isolated from the methanolic extract of the rhizomes of Curcuma comosa cultivated in Thailand. Their structures were elucidated on the basis of chemical and physicochemical evidence. | 18,981,614 |
Incidence and clinical significances of human T-cell lymphotropic virus type I-associated myelopathy with T2 hyperintensity on spinal magnetic resonance images. | To clarify the incidence and clinical significance of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) showing T2 hyperintensity in the spinal cord on magnetic resonance images (MRI). We reviewed the spinal cord MRI of 38 HAM/TSP patients and analyzed them in relation to clinical and laboratory findi... | 18,981,631 |
Establishment of an efficient enzyme-linked immunosorbent assay for the detection of Eperythrozoon sius antibody in swine. | The Eperythrozoon suis (E. suis) antigen was purified using a Sephadex G-200 chromatograph, and thereby, a high-affinity, specific E. suis antigen was collected and confirmed with Western blotting. Using this antigen, an enzyme-linked immunosorbent assay (ELISA) system to detect the antibody against E. suis in swine wa... | 18,981,677 |
[Bio-database literacy and its application with cis-regulatory modules to find novel drug target proteins]. | We have expected Bioinformatics as tools to extract new knowledge from whole genome sequences of various organisms. In the post-genome era, to find some knowledge of the gene regulation including locations of cis-regulatory elements, modules and those combinations became one of the big challenges on Bioinformatics fiel... | 18,981,686 |
Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury. | Flaxseed (FS) has high contents of omega-3 fatty acids and lignans with antioxidant properties. Its use in preventing thoracic X-ray radiation therapy (XRT)-induced pneumonopathy has never been evaluated. We evaluated FS supplementation given to mice given before and post-XRT. FS-derived lignans, known for their direct... | 18,981,722 |
Current concepts of neurohormonal activation in heart failure: mediators and mechanisms. | Neurohormonal activation is a commonly cited array of phenomena in the body's physiologic response to heart failure. Although various neurohormones and pharmacologic agents that moderate their pathophysiologic effects have been reviewed in the nursing literature, both the mechanisms of neurohormonal system activation a... | 18,981,739 |
Chronic wound infection and antimicrobial use. | To provide the wound care practitioner with a review of the assessment and management of chronic wound infection. This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. After reading this article and taking this test, the reader should be able to: 1. Discuss th... | 18,981,758 |
Event reporting: the value of a nonpunitive approach. | This article will discuss why patient safety has been so hard to achieve due to long standing beliefs that when errors occur individuals must be blamed or punished. It will offer suggestions as to how a culture of learning can be advanced by fostering a different approach to medical errors and how reporting systems and... | 18,981,789 |
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