title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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One-stage repair of severe hypospadias using modified tubularized transverse preputial island flap with V-incision suture. | Although hypospadias repair for preserving the urethral plate is popular among pediatric urologists, applying this procedure to severe hypospadias is controversial. We report the outcome of applying additional modifications to the modified tubularized transverse preputial island flap (TPIF) procedure reported previousl... | 19,013,413 |
Hypoxia-inducible factor 1alpha is deregulated by the serum of rats with adjuvant-induced arthritis. | Rheumatoid arthritis (RA) is known to be associated with increased risks of hypoxia-related diseases, whose progresses are critically determined by HIF-1alpha. The authors hypothesized that the hypoxia-related complications of RA are associated with HIF-1alpha deregulation by some factor(s) in RA serum. Arthritis was i... | 19,013,431 |
Novel progesterone receptor modulators with gene selective and context-dependent partial agonism. | Progesterone receptor (PR) modulators are used in contraception and post-menopausal hormone therapy, and are under clinical development for reproductive disorders such as uterine fibroids and endometriosis. Development of tissue selective PR modulators (SPRMs) with reduced side effects and improved pharmacology represe... | 19,013,437 |
Maternal Interferon Regulatory Factor 6 is required for the differentiation of primary superficial epithelia in Danio and Xenopus embryos. | Early in the development of animal embryos, superficial cells of the blastula form a distinct lineage and adopt an epithelial morphology. In different animals, the fate of these primary superficial epithelial (PSE) cells varies, and it is unclear whether pathways governing segregation of blastomeres into the PSE lineag... | 19,013,452 |
Isolation of human proteasomes and putative proteasome-interacting proteins using a novel affinity chromatography method. | The proteasome is the primary subcellular organelle responsible for protein degradation. It is a dynamic assemblage of 34 core subunits and many differentially expressed, transiently interacting, modulatory proteins. This paper describes a novel affinity chromatography method for the purification of functional human ho... | 19,013,454 |
Posterior capsule opacification. | Posterior Capsule Opacification (PCO) is the most common complication of cataract surgery. At present the only means of treating cataract is by surgical intervention, and this initially restores high visual quality. Unfortunately, PCO develops in a significant proportion of patients to such an extent that a secondary l... | 19,013,456 |
Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis. | Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in American children. Noninvasive means to discriminate between NAFLD and nonalcoholic steatohepatitis (NASH) might diminish the requirement for liver biopsy or predict those at increased risk for progression. Data obtained prospectively from ... | 19,013,463 |
Coordinated responses to developmental hormones in the Kenyon cells of the adult worker honey bee brain (Apis mellifera L.). | The brains of experienced forager honey bees exhibit predictable changes in structure, including significant growth of the neuropil of the mushroom bodies. In vertebrates, members of the superfamily of nuclear receptors function as key regulators of neuronal structure. The adult insect brain expresses many members of t... | 19,013,465 |
Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment. | Assessments for potential impact to human health from environmental exposures were carried out for 44 active pharmaceutical ingredients (APIs) marketed by GlaxoSmithKline (GSK), representing approximately 22 general pharmacological classes exhibiting a broad spectrum of therapeutic activities. These assessments use the... | 19,013,494 |
2-Deoxy-d-glucose protects neural progenitor cells against oxidative stress through the activation of AMP-activated protein kinase. | 2-Deoxy-d-glucose (2DG) is an analog of glucose that is effectively taken up by cells competing with normal glucose but cannot be further utilized to produce energy. It was previously reported that 2DG can mimic the beneficial effects of dietary restriction in experimental models of neurodegenerative disorders and canc... | 19,013,500 |
The complete mitochondrial genome of Macaca thibetana and a novel nuclear mitochondrial pseudogene. | The complete mitochondrial genome of Macaca thibetana was determined by the long and accurate polymerase chain reaction (LA-PCR) and primer walking sequencing methods. It is 16,540 bp and contains 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes and one control region. Most codon usage followed t... | 19,013,508 |
Sildenafil augments early protective transcriptional changes after ischemia in mouse myocardium. | Recently, targeting cyclic-GMP specific phosphodiesterase-5 (PDE5) has attracted much interest in several cardiopulmonary diseases, in particular myocardial ischemia (MI). Although multiple mechanisms were postulated for these beneficial effects at cellular level, early transcriptional changes were unknown. The aim of ... | 19,013,509 |
Ophthalmic timolol in a hydrogel vehicle leads to minor inter-individual variation in timolol concentration in aqueous humor. | Ophthalmic timolol has been used for decades in the treatment of glaucoma and ocular hypertension, traditionally in aqueous 0.5% eye drops. Recently a timolol 0.1% hydrogel has been developed to improve systemic safety. The aim of the present study was to compare aqueous humor timolol concentrations after administratio... | 19,013,521 |
Control of Dead end localization and activity--implications for the function of the protein in antagonizing miRNA function. | Dead end (dnd) is a vertebrate-specific component of the germ plasm and germ-cell granules that is crucial for germ-cell development in zebrafish and mouse. Dnd counteracts the inhibitory function of miRNAs, thereby facilitating the expression of proteins such as Nanos and Tdrd7 in the germ cells. Here, we show that ci... | 19,013,519 |
Time-dependent adaptation in the hemodynamic response to hypoxia. | In rats, acute exposure to hypoxia causes a decrease in mean arterial pressure (MAP) caused by a predominance of hypoxic vasodilation over chemoreflex-induced vasoconstriction. We previously demonstrated that exposure to chronic intermittent hypoxia (CIH) impairs hypoxic vasodilation in isolated resistance arteries; th... | 19,013,546 |
Memory for an imagined pathway and strategy effects in sighted and in totally congenitally blind individuals. | The literature reports mixed results on the imagery abilities of the blind, at times showing a difference between sighted and blind individuals and at other times similarities. However, the possibility that the results are due to different strategies spontaneously used in performing the imagery tasks has never been sys... | 19,013,547 |
A comparison of primary and passaged chondrocytes for use in engineering the temporomandibular joint. | This study examines the tissue engineering potential of passaged (P3) and primary (P0) articular chondrocytes (ACs) and costal chondrocytes (CCs) from skeletally mature goats for use in the temporomandibular joint (TMJ). These four cell types were assembled into scaffoldless tissue engineered constructs and cultured fo... | 19,013,549 |
Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala. | Cardiovascular disease (CVD) is a major source of medical comorbidity for patients with mood and anxiety disorders, and it remains the leading public health burden for the general population in industrialized nations. Indirect neurobiological evidence suggests that preclinical risk for atherosclerosis, the main contrib... | 19,013,557 |
Dietary intervention with Okinawan vegetables increased circulating endothelial progenitor cells in healthy young women. | Circulating endothelial progenitor cells (EPCs) play a critical role in maintaining the integrity of vascular vessels. The number of EPCs inversely correlates with the number of atherosclerotic risk factors. Although nonpharmacological treatment represents the first approach to the primary prevention of atherosclerotic... | 19,013,573 |
The relationship between nocturnal polyuria and the distribution of body fluid: assessment by bioelectric impedance analysis. | Increased nocturnal urinary volume is closely associated with nocturia. We investigated the relationship between nocturnal polyuria and the variation of body fluid distribution during the daytime using bioelectric impedance analysis. A total of 34 men older than 60 years were enrolled in this study. A frequency volume ... | 19,013,595 |
Single institution 2-year patient reported validated sexual function outcomes after nerve sparing robot assisted radical prostatectomy. | To identify surgeon specific factors for preserving sexual function (and minimize patient related factors) we report 2-year potency outcomes in men 65 years or younger with normal preoperative sexual function undergoing nerve sparing robot assisted laparoscopic radical prostatectomy. Between July 2004 and February 2006... | 19,013,596 |
Serum biomarker measurements of endothelial function and oxidative stress after daily dosing of sildenafil in type 2 diabetic men with erectile dysfunction. | We investigated changes in serum biomarkers of vascular function after short-term, continuous sildenafil dosing in men with type 2 diabetes with erectile dysfunction. Men with erectile dysfunction associated with type 2 diabetes mellitus were randomized to receive continuous, daily sildenafil (50 mg for 1 week run-in a... | 19,013,603 |
Bladder neck transection for intractable pediatric urinary incontinence. | We report the indications, technique and outcome of a large series of children who underwent bladder neck transection for intractable urinary incontinence. We retrospectively reviewed demographics, operative details, complications and outcomes of 76 patients (47 males, 29 females) who underwent bladder neck closure at ... | 19,013,617 |
Gene delivery in vitro and in vivo from bioreducible multilayered polyelectrolyte films of plasmid DNA. | Layer-by-layer (LbL) films were assembled on flexible stainless steel substrate using plasmid DNA and reducible hyperbranched poly(amido amine) (RHB) polycation. The films were characterized by XPS and their disassembly in reducing conditions confirmed by ellipsometry. Fibroblast and smooth muscle cell attachment and p... | 19,013,638 |
IGF-I, EGF, and sex steroids regulate autophagy in bovine mammary epithelial cells via the mTOR pathway. | Mammary gland growth and involution are based on a dynamic equilibrium between proliferation and apoptosis of mammary epithelial cells (MEC). The main type of cell death responsible for bovine mammary gland involution is apoptosis, but MEC also exhibit morphological features of autophagy. The present study has been und... | 19,013,662 |
Utility of spa typing for investigating the local epidemiology of MRSA on a UK intensive care ward. | In the UK, meticillin-resistant Staphylococcus aureus (MRSA) is frequently endemic on intensive care units (ICUs), yet our understanding of the local epidemiology of MRSA within the ICU is poor and the best methods for preventing MRSA acquisition remain controversial. Newer molecular typing methods may aid epidemiologi... | 19,013,682 |
Impacts of the physiochemical properties of chlorinated solvents on the sorption of trichloroethylene to the roots of Typha latifolia. | Sorption to plant roots is the first step for organic contaminants to enter plant tissues. Mounting evidence is showing that sorption to plant roots is nonlinear and competitive. The objective of this study was to investigate the effects of physiochemical properties of homologous chlorinated ethenes and ethanes on the ... | 19,013,701 |
Immunosurveillance of pancreatic adenocarcinoma: insights from genetically engineered mouse models of cancer. | The resurgent theory of cancer immunosurveillance holds that the immune system plays an important role in the suppression of tumors, particularly in the elimination of early neoplastic lesions. Tumors with reduced immunogenicity or those that have acquired mechanisms to suppress immune effector functions, however, can ... | 19,013,709 |
Anti-Trichomonas vaginalis activity of synthetic lipophilic diamine and amino alcohol derivatives. | Taking in account the increased prevalence of metronidazole-resistant infections, alternative drugs are necessary for the treatment of trichomonosis. We report in this work the preparation and the in vitro anti-trichomonads activity of two diamines 1 and 2, and three different lipophilic amino alcohol derivatives 3, 4 ... | 19,013,752 |
Effect of carvedilol on pulse pressure and left ventricular hypertrophy in spontaneously hypertensive rats with adriamycin nephropathy. | Recent studies indicated pulse pressure as a risk factor for left ventricular hypertrophy, myocardial infarction, congestive heart failure and stroke as well as chronic renal failure progression. The present study examined the effects of carvedilol and its combination with captopril on blood pressure, left ventricular ... | 19,013,753 |
Poor reporting of search strategy and conflict of interest in over 250 narrative and systematic reviews of two biologic agents in arthritis: a systematic review. | To evaluate the quality of reviews about etanercept (ETN) and infliximab (IFX), two biologic treatments for rheumatoid arthritis (RA). A comprehensive, systematic review, including searches of MEDLINE, EMBASE, and other electronic databases and hand-searches for published and unpublished literature. Two raters independ... | 19,013,763 |
Prediction of risk of COPD exacerbations by the BODE index. | This study assesses the power of the BODE index, a multidimensional grading system that predicts mortality, to predict subsequent exacerbations in patients with COPD. Prospective cohort study. A total of 275 COPD patients were followed every 6 months up to 8 years (median of 5.1 years). Baseline clinical variables were... | 19,013,781 |
Patient-reported outcomes: assessment and current perspectives of the guidelines of the Food and Drug Administration and the reflection paper of the European Medicines Agency. | Patient-reported outcomes (PROs) have recently gained greater credibility with regulatory bodies aiming to standardise their use and interpretation in RCTs, thereby supporting medicinal product submissions. For this reason, the United States (US) Food and Drug Administration (FDA) and the European Medicines Agency (EME... | 19,013,787 |
Acute subdural hematoma after transsphenoidal surgery. | We report the case of a 48-year-old male who developed an acute subdural hematoma after transsphenoidal decompression of a pituitary adenoma followed by a lumbar drain to conservatively manage postoperative cerebrospinal fluid rhinorrhoea. An attempt is made to discuss the risk factors. The need for constant monitoring... | 19,013,804 |
Three adolescents with Lhermitte-Duclos disease. | Lhermitte-Duclos disease (LDD) is a rare, benign cerebellar disorder, characterized by replacement of granular cells and Purkinje cells by an overgrowth of cerebellar ganglion cells. LDD can be associated with Cowden's syndrome (CS). We studied three adolescent LDD patients, including two with CS. MRI revealed the typi... | 19,013,808 |
Comorbidities and their impact on mortality in HCV and HCV-HIV-coinfected persons on dialysis. | To determine the rates of non-human immuno deficiency virus (HIV)-related comorbidities and their impact on survival in hepatitis C virus (HCV) and HCV-HIV coinfected persons on dialysis. We identified HCV-infected subjects and diagnoses of medical and psychiatric comorbidities in the United States Renal Data System us... | 19,013,829 |
The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies. | The human brain endothelial capillary cell line hCMEC/D3 has been developed recently as a model for the human blood-brain barrier. In this study a further characterization of this model was performed with special emphasis on permeability properties and active drug transport. Para- or transcellular permeabilities (P(e))... | 19,013,850 |
Advanced imaging technologies for mapping cadaveric lymphatic anatomy: magnetic resonance and computed tomography lymphangiography. | Lymphatic anatomy has become increasingly clinically important as surgical techniques evolve for investigating and treating cancer metastases. However, due to limited anatomical techniques available, research in this field has been insufficient. The techniques of computed tomography (CT) and magnetic resonance (MR) lym... | 19,013,880 |
Trabeculectomy with mitomycin-C in neovascular galucoma patients. | We sought to determine the effectiveness of trabeculectomy with mitomycin-C (MMC) in neovascular glaucoma (NVG) patients. Trabeculectomy with MMC in NVG patients is a method that has high rate of short-term success. | 19,013,913 |
Clinical and coronary angiographic characteristics of patients with coronary slow flow. | The coronary slow flow phenomenon is an angiographic finding characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease, and is an important clinical entity because it may be the cause of angina at rest or during exercise, acute myocardial infarction, and hypertension... | 19,014,000 |
High prevalence of the metabolic syndrome in hypertensive rural Chinese women. | The metabolic syndrome has become a major public health issue worldwide.This study was designed to evaluate and compare the epidemiological features of the metabolic syndrome in hypertensive rural Chinese women. A cross-sectional survey was conducted during 2004-2006, which undertook cluster multistage sampling to a re... | 19,014,002 |
Lack of association between endothelial nitric oxide synthase gene polymorphisms and risk of premature coronary artery disease in the Greek population. | Genetic polymorphisms in the gene for endothelial nitric oxide synthase have been considered as potential risk factors for the development of coronary artery disease in some populations. We studied two polymorphisms of the NOS3 gene, the VNTR in intron 4 (4VNTR) and the Glu298Asp polymorphism in exon 7, in relation to ... | 19,014,005 |
Lasers in cosmetic dentistry. | Lasers have become a necessary instrument in the esthetic restorative armamentarium. This article presents smile design guidelines for soft tissue lasers, as well as an overview of hard tissue procedures that may be performed using all-tissue lasers. The goal is to help dentists determine the appropriate laser for a gi... | 19,014,026 |
A comprehensive treatment approach focusing on the restoration of the anterior maxilla. | Proper diagnosis, thorough evaluation, and a comprehensive treatment plan are fundamental to restoring each patient's oral health and esthetic concerns. This case report presents the strategy of a comprehensive evaluation, diagnosis, and treatment focusing on the patient's compromised anterior maxillary dentition. Oral... | 19,014,031 |
Neuroendocrine carcinoma of the oral cavity: a case report and review of the literature. | Neuroendocrine (NE) carcinoma is a rare disease originating from the NE cell system, which is considered to be the third division of the nervous system. Based on their biological characteristics, NE carcinomas are classified into three subtypes: well-differentiated NE carcinoma (typical carcinoid tumor), moderately dif... | 19,014,033 |
Diabetes mellitus in a nanday conure (Nandayus nenday). | A 3-year-old male nanday conure (Nandayus nenday) was presented with acute lethargy, polyuria, and polydipsia. Marked persistent hyperglycemia, glycosuria, and ketonuria were also noted. The serum insulin concentration (< 3 microU/ml) was lower than reference ranges described for other psittacine birds. Initial trea... | 19,014,099 |
[Educational campaign targeting high school smokers]. | The problem of smoking among young people continues to be a major health problem. In this study, high school students from the provinces of Rimini and Ravenna were invited to take the carbon monoxide test, in order to investigate the main reasons behind their smoking behaviour and to analyse attitudes towards changing ... | 19,014,106 |
Providing patients with information on caring for skin. | This article examines why healthcare professionals may find it difficult to advise patients about care of chronic skin conditions such as psoriasis, eczema and acne. Strategies that might be helpful in improving advice for patients are discussed. | 19,014,143 |
Management and prevention of diabetic foot ulcers and infections: a health economic review. | Diabetic foot ulcers and infections are common and incur substantial economic burden for society, patients and families. We performed a comprehensive review, on a number of databases, of health economic evaluations of a variety of different prevention, diagnostic and treatment strategies in the area of diabetic foot ul... | 19,014,203 |
Within-subjects experiments on blocking and facilitation in honeybees (Apis mellifera). | It has long been suspected in the vertebrate literature, but demonstrated only recently in work with honeybees (Apis mellifera), that the different treatments of nontarget stimuli in conventional between-groups blocking experiments may give the appearance of blocking independently of experience with the target stimulus... | 19,014,261 |
Personality in free-ranging Hanuman langur (Semnopithecus entellus) males: subjective ratings and recorded behavior. | The authors obtained behavioral observations and personality ratings for 27 free-ranging Hanuman langur males. Subjects were rated using a questionnaire based on the human Five-Factor Model (FFM). Behavioral observations were taken over 5 months using an ethogram that included 50 behaviors. Principal Component Analysis... | 19,014,262 |
Aping humans: age and sex effects in chimpanzee (Pan troglodytes) and human (Homo sapiens) personality. | Ratings of 202 chimpanzees on 43 personality descriptor adjectives were used to calculate scores on five domains analogous to the human Five-Factor Model and a chimpanzee-specific Dominance domain. Male and female chimpanzees were divided into five age groups ranging from juvenile to old adult. Internal consistencies a... | 19,014,265 |
Veterinarian-client-patient communication during wellness appointments versus appointments related to a health problem in companion animal practice. | To compare the clinical interview process, content of the medical dialog, and emotional tone of the veterinarian-client-patient interaction during wellness appointments and appointments related to a health problem in companion animal practice. Cross-sectional descriptive study. A random sample of 50 companion animal pr... | 19,014,290 |
Successful treatment of head shaking by use of infrared diode laser deflation and coagulation of corpora nigra cysts and behavioral modification in a horse. | A 15-year-old Saddlebred gelding used for competitive pleasure driving had a 1-year history of head shaking while pulling a cart. The horse had cystic corpora nigra in both eyes and concomitant classic and operant conditioned responses to wearing a bridle with bilateral eye covers (blinkers). Deflation and coagulation ... | 19,014,298 |
Single-case experimental designs for the evaluation of treatments for self-injurious and suicidal behaviors. | Single-case experimental designs (SCEDs) provide a time- and cost-effective alternative to randomized clinical trials and offer significant advantages in terms of internal and external validity. A brief history and primer on SCEDs is provided, specifically for use in suicide intervention research. Various SCED methodol... | 19,014,302 |
University students' perceived self-efficacy in identifying suicidal warning signs and helping suicidal friends find campus intervention resources. | Currently, suicide is the third leading cause of death among youth 18 to 24 years of age and the second leading cause of death on college campuses. A sample of students (N = 1,019) from three midwestern universities were surveyed regarding their perceived self-efficacy in identifying suicide warning signs and campus su... | 19,014,311 |
Expression of opioid growth factor (OGF)-OGF receptor (OGFr) axis in human nonmedullary thyroid cancer. | Although thyroid cancers are readily treatable with surgery and radioactive iodine, there are problems in managing recurring, as well as locally advanced, thyroid cancer. The opioid growth factor (OGF) and its receptor, OGF receptor (OGFr), form a tonically active, autocrine-paracrine loop that serves to inhibit cell p... | 19,014,324 |
Purification and characterization of human phosphatidylserine synthases 1 and 2. | PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. The PS synthesis in cultured mammalian cells is inh... | 19,014,349 |
Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments. | TGases (transglutaminases) are a class of calcium-dependent enzymes that catalyse the interactions between acyl acceptor glutamyl residues and amine donors, potentially making cross-links between proteins. To assess the activity of apple (Malus domestica) pollen TGase on the functional properties of actin and tubulin, ... | 19,014,351 |
Expression and distribution of 'high affinity' glutamate transporters GLT1, GLAST, EAAC1 and of GCPII in the rat peripheral nervous system. | l-Glutamate is one of the major excitatory neurotransmitters in the mammalian central nervous system, but recently it has been shown to have a role also in the transduction of sensory input at the periphery, and in particular in the nociceptive pathway. An excess of glutamate is implicated in cases of peripheral neurop... | 19,014,361 |
Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation. | The microtubule associated protein tau is a major component of neurofibrillary tangles in Alzheimer disease brain, however the neuropathological processes behind the formation of neurofibrillary tangles are still unclear. Previously, 14-3-3 proteins were reported to bind with tau. 14-3-3 Proteins usually bind their tar... | 19,014,373 |
Relationship of CSF neurotransmitter metabolite levels to disease severity and disability in multiple sclerosis. | Axonal degeneration and brain tissue loss occur during disease progression in multiple sclerosis (MS) and are expected to influence neurotransmitter activities, with consequences on neurologic and psychiatric symptomatology. We searched for relationships of disease duration, disability, and severity of MS patients to C... | 19,014,375 |
Understanding your inhibitions: effects of GABA and GABAA receptor modulation on brain cortical metabolism. | A targeted neuropharmacological, (1)H/(13)C NMR spectroscopy and multivariate statistical approach was used to examine the effects of exogenous GABA and ligands at the GABA(A) receptor family on brain metabolism in the Guinea pig cortical tissue slice. All ligands at GABA(A) receptors generated metabolic patterns which... | 19,014,380 |
Evaluation of safety and efficacy of topical prostaglandin E2 in treatment of vitiligo. | Prostaglandin E2 (PGE2) has stimulant and immunomodulatory effects on melanocytes and regulates their proliferation. To study the efficacy and safety of topical PGE2 in treating stable vitiligo patches involving <5% body surface area. Fifty-six consecutive patients with clinically diagnosed stable vitiligo of types ... | 19,014,395 |
Women's attitude towards prenatal screening for red blood cell antibodies, other than RhD. | Since July 1998 all Dutch women (+/- 200,000/y) are screened for red cell antibodies, other than anti-RhesusD (RhD) in the first trimester of pregnancy, to facilitate timely treatment of pregnancies at risk for hemolytic disease of the fetus and newborn (HDFN). Evidence for benefits, consequences and costs of screening... | 19,014,424 |
Delayed diagnosis of intermittent mesenteroaxial volvulus of the stomach by computed tomography: a case report. | Gastric volvulus is a rare condition. Presenting acutely, mesenteroaxial gastric volvulus has characteristic symptoms and may be easily detected with upper gastrointestinal contrast studies. In contrast, subacute, intermittent cases present with intermittent vague symptoms from episodic twisting and untwisting. Imaging... | 19,014,426 |
Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients. | Studies on asbestos-induced tumourigenesis have indicated the role of, e.g., reactive oxygen/nitrogen species, mitochondria, as well as NF-kappaB and MAPK signalling pathways. The exact molecular mechanisms contributing to asbestos-mediated carcinogenesis are, however, still to be characterized. In this study, gene exp... | 19,014,429 |
Surgical strategies for treatment of malignant pancreatic tumors: extended, standard or local surgery? | Tumor related pancreatic surgery has progressed significantly during recent years. Pancreatoduodenectomy (PD) with lymphadenectomy, including vascular resection, still presents the optimal surgical procedure for carcinomas in the head of pancreas. For patients with small or low-grade malignant neoplasms, as well as sma... | 19,014,474 |
Sox genes in the coral Acropora millepora: divergent expression patterns reflect differences in developmental mechanisms within the Anthozoa. | Sox genes encode transcription factors that function in a wide range of developmental processes across the animal kingdom. To better understand both the evolution of the Sox family and the roles of these genes in cnidarians, we are studying the Sox gene complement of the coral, Acropora millepora (Class Anthozoa). Base... | 19,014,479 |
XM02 is superior to placebo and equivalent to Neupogen in reducing the duration of severe neutropenia and the incidence of febrile neutropenia in cycle 1 in breast cancer patients receiving docetaxel/doxorubicin chemotherapy. | Recombinant granulocyte colony-stimulating factors (G-CSFs) such as Filgrastim are used to treat chemotherapy-induced neutropenia. We investigated a new G-CSF, XM02, and compared it to Neupogen after myelotoxic chemotherapy in breast cancer (BC) patients. A total of 348 patients with BC receiving docetaxel/doxorubicin ... | 19,014,494 |
Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome. | In this report we describe the genomic sequence of guinea pig cytomegalovirus (GPCMV) assembled from a tissue culture-derived bacterial artificial chromosome clone, plasmid clones of viral restriction fragments, and direct PCR sequencing of viral DNA. The GPCMV genome is 232,678 bp, excluding the terminal repeats, and ... | 19,014,498 |
Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment. | Research using the zebrafish model has experienced a rapid growth in recent years. Although real-time reverse transcription PCR (QPCR), normalized to an internal reference ("housekeeping") gene, is a frequently used method for quantifying gene expression changes in zebrafish, many commonly used housekeeping genes are k... | 19,014,500 |
The responsiveness of the uterine fibroid symptom and health-related quality of life questionnaire (UFS-QOL). | A number of noninvasive alternatives to hysterectomy have become available as treatments for uterine fibroids. These alternative therapies, however, may not relieve all symptoms. Consequently, the need for patient-reported outcomes to assess symptom reduction of uterine fibroids has become increasingly important to eva... | 19,014,505 |
Determinants of non attendance to mammography program in a region with high voluntary health insurance coverage. | High participation rates are needed to ensure that breast cancer screening programs effectively reduce mortality. We identified the determinants of non-participation in a public breast cancer screening program. In this case-control study, 274 women aged 50 to 64 years included in a population-based mammography screenin... | 19,014,522 |
Cytokine activation is predictive of mortality in Zambian patients with AIDS-related diarrhoea. | Mortality in Zambian AIDS patients is high, especially in patients with diarrhoea, and there is still unacceptably high mortality in Zambian patients just starting anti-retroviral therapy. We set out to determine if high concentrations of serum cytokines correlate with mortality. Serum samples from 30 healthy controls ... | 19,014,537 |
Transcriptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis. | Bacillus anthracis secretes several virulence factors targeting different host organs and cell types during inhalational anthrax infection. The bacterial expression of a key virulence factor, lethal toxin (LeTx) is closely tied to another factor, edema toxin (EdTx). Both are transcribed on the same virulence plasmid (p... | 19,014,542 |
Alkaptonuria diagnosed in a 4-month-old baby girl: a case report. | The mother of a four month old female baby attended in the well baby clinic with the complaint of black staining of the diaper after few minutes of urination. The baby was born of a non consanguineous marriage, healthy and breast fed. Mother noticed that stain first at the age of two and half month. The urine when kep... | 19,014,543 |
The Kv2.1 K+ channel targets to the axon initial segment of hippocampal and cortical neurons in culture and in situ. | The Kv2.1 delayed-rectifier K+ channel regulates membrane excitability in hippocampal neurons where it targets to dynamic cell surface clusters on the soma and proximal dendrites. In the past, Kv2.1 has been assumed to be absent from the axon initial segment. Transfected and endogenous Kv2.1 is now demonstrated to pref... | 19,014,551 |
Atypical presentation of "takotsubo cardiomyopathy" without ST segment elevation: a case report. | "Takotsubo cardiomyopathy" is characterized by transient LV dysfunction and mimicking acute myocardial infarction. We reported a case with atypical presentation of "takotsubo cardiomyopathy" without ST segment elevation, but with severe transient left ventricular dysfunction. Diagnosis of "takotsubo cardiomyopathy" sho... | 19,014,564 |
Malignant mesothelioma of the tunica vaginalis of the testis without exposure to asbestos. | Mesotheliomas are rare tumours that usually are seen in the pleura after asbestos exposure. Mesotheliomas have been reported around the testicular region but are even rarer following trauma, herniorrhaphy and long term hydrocoele. An elderly male farmer presented to us with an insidious onset of painless swelling in hi... | 19,014,568 |
Spermatogonial stem cell sensitivity to capsaicin: an in vitro study. | Conflicting reports have been published on the sensitivity of spermatogenesis to capsaicin (CAP), the pungent ingredient of hot chili peppers. Here, the effect of CAP on germ cell survival was investigated by using two testis germ cell lines as a model. As CAP is a potent agonist of the transient receptor potential van... | 19,014,578 |
Age-related differences in dual task walking: a cross sectional study. | Variability in stride velocity during walking characterizes gait instability and predicts falling in older individuals. Walking while executing a cognitive task is also associated with increased risk of falling, particularly in older adults. Variability in stride velocity, particularly during dual task walking conditio... | 19,014,583 |
Cone inputs to murine striate cortex. | We have recorded responses from single neurons in murine visual cortex to determine the effectiveness of the input from the two murine cone photoreceptor mechanisms and whether there is any unique selectivity for cone inputs at this higher region of the visual system that would support the possibility of colour vision ... | 19,014,590 |
The experience of linking Victorian emergency medical service trauma data. | The linking of a large Emergency Medical Service (EMS) dataset with the Victorian Department of Human Services (DHS) hospital datasets and Victorian State Trauma Outcome Registry and Monitoring (VSTORM) dataset to determine patient outcomes has not previously been undertaken in Victoria. The objective of this study was... | 19,014,622 |
Dermatosis neglecta in a case of multiple fractures, shoulder dislocation and radial nerve palsy in a 35-year-old man: a case report. | Dermatosis neglecta is an often misdiagnosed and under-diagnosed condition. In dermatosis neglecta, a progressive accumulation of sebum, sweat, keratin and other dirt and debris, occurs due to inadequate local hygiene resulting in a localized hyperpigmented patch or a verrucous plaque. Vigorous rubbing with alcohol-soa... | 19,014,627 |
Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters. | Organophosphates are broad class of chemicals widely used as pesticides throughout the world. We performed a cross-sectional study of associations between dialkylphosphate metabolites of organophosphates and semen quality among pesticide applicators in Majes (Arequipa), Peru. Thirty-one men exposed to organophosphate (... | 19,014,632 |
Connective tissue growth factor promoter activity in normal and wounded skin. | In skin, connective tissue growth factor (CTGF/CCN2) is induced during tissue repair. However, what the exact cell types are that express CTGF in normal and wounded skin remain controversial. In this report, we use transgenic knock-in mice in which the Pacific jellyfish Aequorea victoria enhanced green fluorescent prot... | 19,014,648 |
High-efficiency Rosa26 knock-in vector construction for Cre-regulated overexpression and RNAi. | Rosa26 is a genomic mouse locus commonly used to knock-in cDNA constructs for ubiquitous or conditional gene expression in transgenic mice. However, the vectors generally used to generate Rosa26 knock-in constructs show instability problems, which have a severe impact on the efficiency of the system. We have optimized ... | 19,014,667 |
Expression profiles of switch-like genes accurately classify tissue and infectious disease phenotypes in model-based classification. | Large-scale compilation of gene expression microarray datasets across diverse biological phenotypes provided a means of gathering a priori knowledge in the form of identification and annotation of bimodal genes in the human and mouse genomes. These switch-like genes consist of 15% of known human genes, and are enriched... | 19,014,681 |
Effect of foot orthoses on lower extremity kinetics during running: a systematic literature review. | Throughout the period of one year, approximately 50% of recreational runners will sustain an injury that disrupts their training regimen. Foot orthoses have been shown to be clinically effective in the prevention and treatment of several running-related conditions, yet the physical effect of this intervention during ru... | 19,014,705 |
Biomimetic poly(amidoamine) hydrogels as synthetic materials for cell culture. | Poly(amidoamine)s (PAAs) are synthetic polymers endowed with many biologically interesting properties, being highly biocompatible, non toxic and biodegradable. Hydrogels based on PAAs can be easily modified during the synthesis by the introduction of functional co-monomers. Aim of this work is the development and testi... | 19,014,710 |
Spontaneous improvement of a haemodynamically significant ventricular septal defect produced by blunt chest trauma in a child. | We describe the progress of a girl aged 5 years, who suffered blunt trauma to the chest producing a ventricular septal defect of 1 centimetre in diameter. The shunt generated a mild dilation of the left-sided chambers, and exertional dyspnoea. Three months later, therapeutic catheterisation revealed important diminutio... | 19,014,715 |
[Psychosis in affective disorders]. | Psychosis in affective disorder is prevalent as 15-20% of depressive patients and approximately 50% of manic patients present with psychotic features. Psychosis in conjunction with affective disorder has a poor prognosis. It is particularly so for depression where psychosis is associated with an increased risk of recur... | 19,014,720 |
[Psychosis and crime]. | The number of forensic patients has increased dramatically in Denmark as well as in many other countries during the last three decades. The patients predominantly suffer from schizophrenia. The offences committed by the patients are often violence. The increasing number of forensic patients has been linked to a decreas... | 19,014,727 |
[Have the 2005 guidelines for resuscitation been implemented?]. | In 2005, new international evidence-based guidelines for cardiopulmonary resuscitation (CPR) were published by the International Liaison Committee on Resuscitation (ILCOR). The aim of these new guidelines is to improve the quality of care and, thereby, the outcome from cardiac arrest. This necessitates that the guideli... | 19,014,735 |
[Glucagonoma syndrome without diabetes mellitus]. | A patient developed depression, weight loss, ulcers and a migrating, denuded erythematous skin area. Punch biopsy revealed necrolytic migrating erythema. Computerised tomography and endoscopic ultrasound showed a solid tumour of the pancreas. A blood sample showed an increased level of glucagon without diabetes. Glucag... | 19,014,744 |
Sleep and dreaming in Greek and Roman philosophy. | Theories as to the function of sleep and dreaming have been with us since the beginning of recorded history. In Ancient Greece and Rome the predominant view of dreams was that they were divine in origin. This view was held not only in theory but also in practice with the establishment of various dream-oracles and dream... | 19,014,776 |
Evaluation of psychiatric symptoms in cocaine users in the Brazilian public health system: need for data and structure. | Few studies of comorbidity among cocaine users have been undertaken in Brazil, despite the fact that cocaine is one of the most commonly used illegal drugs in the country. The aim of this paper is to review existing data on psychiatric evaluations of cocaine users, and present data from two studies that have addressed ... | 19,014,831 |
Efficacy of cefditoren pivoxil and amoxicillin/clavulanate in the treatment of pediatric patients with acute bacterial rhinosinusitis in Thailand: a randomized, investigator-blinded, controlled trial. | The recommended treatment for acute bacterial rhinosinusitis in adults and children is 10 to 14 days of high doses of oral cephalosporins or amoxicillin/clavulanate. This study compared the clinical efficacy and tolerability of cefditoren pivoxil and amoxicillin/clavulanate in children with uncomplicated acute bacteria... | 19,014,842 |
Water softening by combination of ultrasound and ion exchange. | Ion exchange resin used in this work was styrene-divinylbenzene co-polymer with sulfonic acid group as a strong acid cation resin. This resin is particularly well suited for the removal of water hardness. In water treatment, commonly used softening processes are chemical precipitation and ion exchange. In this study, a... | 19,014,894 |
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