title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Role of sexual self-disclosure in the sexual satisfaction of long-term heterosexual couples. | This study examined two proposed pathways between sexual self-disclosure (SSD) and sexual satisfaction in a sample of 104 heterosexual couples in long-term relationships. According to the proposed instrumental pathway, disclosure of sexual preferences increases a partner's understanding of those preferences resulting i... | 19,012,061 |
Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up. | Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of spinal cord and cortical motoneurons. Despite improved understanding of the mechanisms underlying ALS, in clinical practice the management of ALS remains essentially supportive and focused on symptom relief. H... | 19,012,065 |
Handedness and depression: evidence from a large population survey. | There is a considerable body of research arguing for an association between psychotic disorders and atypical brain lateralisation--where non-right-handedness is usually taken as a marker for the latter. By contrast, there has been less attention given to a possible link between handedness and affective disorders (parti... | 19,012,075 |
Institutional support for HIV/AIDS care in China: a multilevel analysis. | A total of 1,101 Chinese healthcare workers were surveyed to determine the perception of institutional support for HIV/AIDS care in China. Multilevel regression models with random effects were used to estimate individual and facility-level effects on healthcare workers' perceived institutional support. Regional workers... | 19,012,080 |
Mismatch negativity (MMN) as an index of central auditory system plasticity. | The mismatch negativity (MMN) is an electric brain response which is automatically elicited by any discriminable change in a repetitive sound or sound pattern. When this change is made smaller in magnitude, the MMN is attenuated in amplitude, eventually vanishing at around the discrimination threshold. Therefore the MM... | 19,012,108 |
Auditory-visual discourse comprehension by older and young adults in favorable and unfavorable conditions. | This investigation examined how age and test condition affect one's ability to comprehend discourse passages, and determined whether age and test condition affect discourse comprehension and closed-set sentence recognition in a similar way. Young and older adults were tested with closed-set sentences from the newly-cre... | 19,012,110 |
Are individual differences in speech reception related to individual differences in cognitive ability? A survey of twenty experimental studies with normal and hearing-impaired adults. | This paper summarizes twenty studies, published since 1989, that have measured experimentally the relationship between speech recognition in noise and some aspect of cognition, using statistical techniques such as correlation or factor analysis. The results demonstrate that there is a link, but it is secondary to the p... | 19,012,113 |
Use of supportive context by younger and older adult listeners: balancing bottom-up and top-down information processing. | Older adults often have more difficulty listening in challenging environments than their younger adult counterparts. On the one hand, auditory aging can exacerbate and/or masquerade as cognitive difficulties when auditory processing is stressed in challenging listening situations. On the other hand, an older listener c... | 19,012,114 |
The interference of different background noises on speech processing in elderly hearing impaired subjects. | The objective of the investigation is to study the interference of different background noises on speech processing. For this purpose speech recognition with the Hagerman test and a test battery with speech comprehension tasks (SVIPS) were performed in speech-weighted background noises varying in temporal structure, si... | 19,012,115 |
Psychiatric education and training in Asia. | Psychiatric education and training, whilst playing a pivotal role in addressing the burden of mental illness in Asia, is very variable in quality and quantity across the continent. In this article formal postgraduate programmes in Indonesia, Thailand, Philippines, Singapore and India are described. The special situatio... | 19,012,125 |
Pharmacotherapy for schizophrenic inpatients in East Asia--changes and challenges. | (1) to review characteristics of prescription patterns of antipsychotic medication in China, Hong Kong, Japan, Korea, Singapore and Taiwan, (2) to examine the changes of prescriptions brought about by the introduction of second generation psychotropic drugs (SGA) in East Asia, (3) to analyse factors contributing to the... | 19,012,132 |
Team effectiveness in academic primary health care teams. | Primary health care is undergoing significant organizational change, including the development of interdisciplinary health care teams. Understanding how teams function effectively in primary care will assist training programs in teaching effective interprofessional practices. This study aimed to explore the views of me... | 19,012,140 |
Leadership styles in interdisciplinary health science education. | The US Institute of Medicine recommends that all health professionals should deliver patient-centered care as members of interdisciplinary health science teams. The current application of the Bolman and Deal Leadership model to health sciences provides an interesting point of reference to compare leadership styles. Thi... | 19,012,143 |
Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry. | Simultaneous analysis of the protein composition of biological fluids is now possible. Such an approach can be used to identify biological markers of disease and to understand the pathophysiology of disorders that have eluded classification, diagnosis, and treatment. The purpose of this study was to analyze the differe... | 19,012,186 |
A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitor. | Vaginal bleeding is a risk factor for preterm PROM (PPROM). A disorder of decidual hemostasis has been implicated in the genesis of PROM. Indeed, excessive thrombin generation has been demonstrated in PPROM both before and at the time of diagnosis. Decidua is a potent source of tissue factor (TF), the most powerful nat... | 19,012,190 |
Different biological properties of circulating and bone marrow endothelial progenitor cells in acute myocardial infarction rats. | Many studies have shown that endothelial progenitor cell (EPC) can enhance the neovascularization of the ischemic myocardium. Peripheral blood and bone marrow are the most convenient resources for EPC. The aim of the study was to investigate, in vitro and in vivo, the different biological properties between circulating... | 19,012,207 |
Lack of correlation between smoking status and early postoperative outcome following valve surgery. | We sought to assess the effect of smoking on early outcome following valve surgery. This is a retrospective review of a prospectively collected departmental database of all patients who underwent isolated aortic and/or mitral valve surgery (replacement and/or repair). Our cohort consisted of 590 patients stratified int... | 19,012,208 |
Should the aortic valve be replaced in patients with mild aortic stenosis admitted for coronary surgery? | The question whether the aortic valve in patients with mild aortic stenosis undergoing coronary artery bypass grafting (CABG) should be replaced or left alone is still controversial. Between 01/1995 and 03/2004, 38 patients (30 male, 8 female, mean age 70.9 +/- 7.8 years) required redo AVR 7.1 +/- 4.8 years after prima... | 19,012,211 |
Case of left atrial metastasis of a sarcomatoid carcinoma. | Metastatic tumor involvement of the heart may occur with all types of primary neoplasms. Right atrial cardiac metastases following vena cava extension from renal cell carcinoma are well recognized, while a left atrial appearance is extremely rare. We report on a patient who developed a left atrial mass originating from... | 19,012,215 |
Bilateral trapped lung with concomitant Wermer's syndrome and cutis laxa. | We report a rare occurrence of trapped lung associated with Wermer's syndrome and cutis laxa. A 25-year-old man with bilateral trapped lung presented with respiratory distress. Additional investigation revealed adenoma of the parathyroid and hypophysis, a neuroendocrine abdominal tumor, and cutis laxa. Successful treat... | 19,012,220 |
[MELAS syndrome as a differential diagnosis of ischemic stroke]. | Mitochondrial encephalomyopathy, lactacidosis and stroke-like episode (MELAS) syndrome is a phenotypically and genetically heterogeneous mitochondrial disorder with a clinical onset between the first and third decade. The clinical hallmark is the stroke-like-episode, which mimicks ischemic stroke but is usually transie... | 19,012,224 |
Left atrial shortening fraction in fetuses with and without myocardial hypertrophy in diabetic pregnancies. | To test the hypothesis that, in diabetic pregnancies, left atrial shortening fraction (LASF) is decreased in fetuses with myocardial hypertrophy, compared to those without hypertrophy and to fetuses of non-diabetic mothers. Fetal echocardiography was performed in women with pre-existing or gestational diabetes and in n... | 19,012,275 |
Fixed effects, random effects and GEE: what are the differences? | For analyses of longitudinal repeated-measures data, statistical methods include the random effects model, fixed effects model and the method of generalized estimating equations. We examine the assumptions that underlie these approaches to assessing covariate effects on the mean of a continuous, dichotomous or count ou... | 19,012,297 |
Asymptomatic Becker muscular dystrophy in a family with a multiexon deletion. | We report a Becker muscular dystrophy (BMD) family with one 5-year-old affected patient and a 69-year-old asymptomatic grandfather. Dystrophin gene multiplex polymerase chain reaction and multiplex ligation-dependant probe amplification analysis showed that both males carried an in-frame deletion of exons 45-55. Segreg... | 19,012,301 |
Bonding in mercury molecules described by the normalized elimination of the small component and coupled cluster theory. | Bond dissociation energies (BDEs) of neutral HgX and cationic HgX(+) molecules range from less than a kcal mol(-1) to as much as 60 kcal mol(-1). Using NESC/CCSD(T) [normalized elimination of the small component and coupled-cluster theory with all single and double excitations and a perturbative treatment of the triple... | 19,012,313 |
Quantification of amounts and (13)C content of metabolites in brain tissue using high- resolution magic angle spinning (13)C NMR spectroscopy. | Metabolic pathway mapping using (13)C NMR spectroscopy has been used extensively to study interactions between neurons and glia in the brain. Established extraction procedures of brain tissue are time consuming and may result in degradation of labile substances. We examined the potential of mapping (13)C-enriched compo... | 19,012,315 |
Bias in a binary risk behaviour model subject to inconsistent reports and dropout in a South African high school cohort study. | We describe a methodology for analysing self-reported risk behaviour transitional patterns in a binary outcome variable, subject to misclassification and a large loss to follow-up. The motivation stems from the analysis of self-reported transitional patterns in responses to the question 'have you ever smoked a whole ci... | 19,012,316 |
Novel mutation of IL1RAPL1 gene in a nonspecific X-linked mental retardation (MRX) family. | Mental retardation (MR) affects approximately 2% of the population. About 10% of all MR cases result from defects of X-linked genes. Mutations in most of more than 20 known genes causing nonspecific form of X-linked MR (MRX) are very rare and may account for less than 0.5-1% of MR. Linkage studies in extended pedigrees... | 19,012,350 |
Band-like intracranial calcification with simplified gyration and polymicrogyria: a distinct "pseudo-TORCH" phenotype. | The combination of intracranial calcification and polymicrogyria is usually seen in the context of intrauterine infection, most frequently due to cytomegalovirus. Rare familial occurrences have been reported. We describe five patients-two male-female sibling pairs, one pair born to consanguineous parents, and an unrela... | 19,012,351 |
Limited utility of rapamycin in severe, refractory Wegener's granulomatosis. | We report our experience using rapamycin in patients with Wegener's granulomatosis (WG) who failed to achieve remission with conventional treatment. Eight patients received rapamycin for severe, refractory WG. Clinical outcomes were reviewed retrospectively. Four patients treated with rapamycin sustained remissions of ... | 19,012,360 |
Competing gas-phase substitution and elimination reactions of gemini surfactants with anionic counterions by mass spectrometry. Density functional theory correlations with their bolaform halide salt models. | Understanding ion specific effects on the solution properties of association colloids is a major unsolved problem, and we are studying the chemistry of gemini surfactants in the gas-phase by mass spectrometry and density functional theory (DFT) to probe ion specific effects in the absence of water. Products from gas-ph... | 19,012,368 |
On the extent and connectivity of conical intersection seams and the effects of three-state intersections. | We discuss the connectivity of intersection spaces and the role of minimal energy points within these intersection spaces (minimal energy conical intersections or MECIs) in promoting nonadiabatic transitions. We focus on malonaldeyde as a specific example, where there is a low-lying three-state conical intersection. Th... | 19,012,385 |
Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases. | A series of tricyclic, conformationally constrained Smac mimetics have been designed, synthesized, and evaluated. The most potent compound 6 (WS-5) binds to XIAP, cIAP-1, and cIAP-2 with K(i) of 18, 1.1, and 4.2 nM, respectively. Compound 6 antagonizes XIAP in a functional assay, induces cIAP-1 degradation, inhibits ce... | 19,012,392 |
Negative APCI-LC/MS/MS method for determination of natural persistent halogenated products in marine biota. | A sensitive and selective method utilizing high performance liquid chromatography coupled to negative atmospheric pressure chemical ionization tandem mass spectrometry (APCI-LC/MS/MS) was developed to enable analysis of selected natural persistent organohalogens accumulated in marine biota. The analytes were three meth... | 19,012,416 |
Testing potential interference with RFID usage in the patient care environment. | The use of radio frequency identification (RFID) equipment in the clinical setting has become prevalent. The exploration of the potential interactions between the equipment used to implement RFID and medical devices is vital to ensure safe and effective use of both the tracking technology and the patient care equipment... | 19,012,466 |
Significant headache improvement after transsphenoidal surgery in patients with small sellar lesions. | Pituitary adenomas represent a large proportion of brain tumors that are increasing in incidence because of improved imaging techniques. Headache is the primary symptom in patients with large tumors (macroadenomas), but is also a symptom in patients with small tumors (microadenomas, tumors < 1.0 cm). The prevalence ... | 19,012,490 |
Novel therapeutics in metastatic bladder cancer. | Albeit transitional cell carcinoma of the urinary bladder is a chemosensitive neoplasm, metastatic disease is related with poor prognosis and short-term survival data. Cisplatin-based combination chemotherapy is recognised as the golden standard therapy for patients with inoperable locally advanced or metastatic bladde... | 19,012,504 |
Health effects of arsenic and chromium in drinking water: recent human findings. | Even at high concentrations, arsenic-contaminated water is translucent, tasteless, and odorless. Yet almost every day, studies report a continually increasing plethora of toxic effects that have manifested in exposed populations throughout the world. In this article we focus on recent findings, in particular those asso... | 19,012,537 |
A statewide system of trauma care in Victoria: effect on patient survival. | To determine whether the statewide system of trauma care introduced in 2000 has resulted in improved survival for all major trauma patients in Victoria. Population-based cohort study using data from the Victorian State Trauma Registry (VSTR), a registry of all hospitalised major trauma patients in Victoria. The study i... | 19,012,550 |
Plasma lipoprotein concentrations in the dog: the effects of gender, age, breed and diet. | Earlier studies of canine lipoprotein metabolism have frequently not taken into account such variables as age, gender, lifestyle or feeding status. In the last years, many changes to lifestyle and feeding of dogs have occurred. In this study, C-tot, C-HDL, C-LDL, triglycerides and lipoprotein fractions were determined ... | 19,012,618 |
Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation. | As activated microglia (MG) is an early sign that often precedes and triggers neuronal death, inhibition of microglial activation and reduction of subsequent neurotoxicity may offer therapeutic benefit. The present study demonstrates that rat primary cultured MG expressed Kir6.1 and SUR2 subunits of K(ATP) channel, whi... | 19,012,619 |
Sociogenomic personality psychology. | In this article, we address a number of issues surrounding biological models of personality traits. Most traditional and many contemporary biological models of personality traits assume that biological systems underlying personality traits are causal and immutable. In contrast, sociogenomic biology, which we introduce ... | 19,012,657 |
Structures of personality and their relevance to psychopathology: II. Further articulation of a comprehensive unified trait structure. | There is increasing agreement that the current categorical system of personality disorders (PDs) in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV; American Psychiatric Association, 2000) should be replaced by a trait dimensional scheme in DSM-V. In particular, the consensus appears t... | 19,012,658 |
The effects of physical exercises to mental state and quality of life in patients with schizophrenia. | The purpose of this study was to examine the effects of 10 weeks of physical exercises programme on mental states and quality of life (QOL) of individuals with schizophrenia. The study involved 30 inpatients or outpatients with schizophrenia who were assigned randomly into aerobic exercise (n = 15) group and control (n... | 19,012,672 |
Cognitive behaviour therapy within assertive outreach teams: barriers to implementation: a qualitative peer audit. | Assertive outreach is an evidence-based intervention, with over 30 well-designed randomized studies demonstrating its effectiveness, predominately in the USA. Assertive outreach teams have recently been implemented in the UK, and it has been recommended that teams should offer cognitive behaviour therapy (CBT) to servi... | 19,012,676 |
Effectiveness of weight management interventions for people with serious mental illness who receive treatment with atypical antipsychotic medications. A literature review. | Weight gain associated with treatment with atypical antipsychotic medication has been widely recognized as a risk factor for the development of diabetes and cardiovascular diseases. A systematic search was conducted of major databases and of citations for material about the effectiveness of weight management interventi... | 19,012,677 |
Cigarette smoking and glutathione S-transferase M1 polymorphism associated with risk for uterine cervical cancer. | To elucidate the role of tobacco smoking and polymorphisms of carcinogen metabolism genes in cervical carcinogenesis. We analyzed genotypes of nine genes, 11 polymorphisms encoding carcinogen metabolizing enzymes, information on smoking, and the presence of human papillomavirus in 124 Japanese cervical cancer patients ... | 19,012,698 |
Does laparoscopic cystectomy and cauterization of endometriomas greater than 3 cm diminish ovarian response to controlled ovarian hyperstimulation during IVF-ET? A case-control study. | The objective of this study is to evaluate the in vitro fertilization and embryo transfer results of patients with endometriomas pretreated with laparoscopic cystectomy and cauterization compared with age-matched tubal infertility patients. Records of the in vitro fertilization and embryo transfer unit have been retros... | 19,012,700 |
Caring for families coping with perinatal loss. | To describe support needs and comfort level of labor nurses caring for families experiencing perinatal loss. Qualitative descriptive study. A western hospital birthing unit. Ten labor nurses. Participants completed online surveys and follow-up interviews; data saturation was reached. Content analysis produced themes an... | 19,012,713 |
Sleep quality in women with and without postpartum depression. | To compare and measure the effects of sleep quality in women with and without postpartum depression. A case-control repeated measures matched pairs design. Home and obstetric office. Forty-six women who were 6 to 26 weeks postpartum. Two participants were dropped from the final analysis because they were outliers. Part... | 19,012,723 |
Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus. | Type 2 diabetes mellitus induces a characteristic platelet hyperactivity that might be due to several factors including oxidative stress and abnormal intracellular Ca(2+) homeostasis. Hyperhomocysteinaemia is considered a risk factor in the development of thrombosis although its effect on platelet function and the mech... | 19,012,728 |
Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. | CD47 or integrin-associated protein promotes cell death in blood and tumor cells. Recently, CD47 signaling has been identified in neurons as well. In this study, we investigated the role of CD47 in neuronal cell death. Exposure of primary mouse cortical neurons to the CD47 ligand thrombospondin-1 or the specific CD47-a... | 19,012,741 |
The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease. | Tetrahydroisoquinoline (TIQ) derivatives are putative neurotoxins that may contribute to the degeneration of dopaminergic neurons in Parkinson's disease. One TIQ, norsalsolinol (NorSAL), is present in dopamine-rich areas of human brain, including the substantia nigra. Here, we demonstrate that NorSAL reduces cell viabi... | 19,012,744 |
Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor. | Our laboratory demonstrated previously that PGE2-induced modulation of hippocampal synaptic transmission is via a pre-synaptic PGE2 EP2 receptor. However, little is known about whether the EP2 receptor is involved in hippocampal long-term synaptic plasticity and cognitive function. Here we show that long-term potentiat... | 19,012,750 |
A review of psychosocial needs of breast-cancer patients and their relatives. | To identify the psychosocial needs of breast-cancer patients and their relatives along with factors affecting these needs and to develop a tentative model to guide further research and need assessments in clinical practice. Women experiencing breast cancer must deal with the diagnosis of a life-threatening illness. Tre... | 19,012,759 |
Drug use and pressure ulcers in long-term care units: do nurse time pressure and unfair management increase the prevalence? | This study examined the associations between nurse working conditions (time pressure and perceived unfair management) and quality indicators (prevalence of antianxiety or hypnotic drug use and pressure ulcers) in long-term care units. Differences persist across long-term care facilities in their care processes and resi... | 19,012,772 |
Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis. | Many essential transcription factors have conserved roles in regulating biological programs, yet their genomic occupancy can diverge significantly. A new study demonstrates that such variations are primarily due to cis-regulatory sequences, rather than differences between the regulators or nuclear environments. | 19,012,800 |
Monetary cost of self-reported diet in relation to biomarker-based estimates of nutrient intake in young Japanese women. | All previous studies on monetary diet cost have examined the relationship of monetary cost of self-reported diet to self-reported, rather than biomarker-based, estimates of dietary intake. The present cross-sectional study examined the association between monetary costs of self-reported diet and biomarker-based estimat... | 19,012,801 |
High sensitivity detection of 16s rRNA using peptide nucleic acid probes and a surface plasmon resonance biosensor. | A signal enhancing method allowing highly sensitive detection of E. coli 16s rRNA was developed using peptide nucleic acid (PNA) as a capture probe and a surface plasmon resonance (SPR) sensor as a detector. 16s rRNA has been used as a genetic marker for identification of organisms, and can be analyzed directly without... | 19,012,828 |
The role of peer e-mail support as part of a college smoking-cessation website. | Helping young smokers to quit early in life substantially reduces the risk of later morbidity and mortality due to tobacco use. The RealU study demonstrated the efficacy of a smoking-cessation website for college students that incorporated both individually tailored feedback and peer e-mail support. The relationship be... | 19,012,841 |
Tobacco-use prevalence in special populations taking advantage of electronic medical records. | It is difficult and expensive to use surveys to obtain the repeatable information that is needed to understand and monitor tobacco prevalence rates and to evaluate cessation interventions among various subgroups of the population. Therefore, the electronic medical record database of a large medical group in Minnesota w... | 19,012,845 |
Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability. | Cell-adhesion molecules play critical roles in brain development, as well as maintaining synaptic structure, function, and plasticity. Here we have found the disruption of two genes encoding putative cell-adhesion molecules, CDH15 (cadherin superfamily) and KIRREL3 (immunoglobulin superfamily), by a chromosomal translo... | 19,012,874 |
Working harder to obtain more snack foods when wanting to eat less. | This study investigates individual differences in the reinforcing value of snack food. More specifically, it was investigated whether differences in restraint status are associated with differences in working for high-caloric snack food. Thirty-six unrestrained non-dieters, twenty restrained non-dieters and fifteen cur... | 19,012,877 |
Internally self-assembled particles entrapped in thermoreversible hydrogels. | The present study describes the development of thermogelling emulsions by the entrapment of internally self-assembled emulsion droplets (ISAsomes) within a thermoreversible hydrogel made of kappa-carrageenan. The droplets are emulsified mesophases of cubic or hexagonal order, or emulsified micro-emulsions. Above 60 deg... | 19,012,899 |
Laparoscopic partial nephrectomy for central tumors: analysis of perioperative outcomes and complications. | We report our experience with laparoscopic partial nephrectomy for central tumors compared to peripheral tumors to analyze the feasibility and safety of the laparoscopic approach to these complex cases. Between October 2002 and July 2007, 212 patients underwent laparoscopic partial nephrectomy. In 53 patients the tumor... | 19,012,908 |
Impact of P2Y(12) inhibitory effects induced by clopidogrel on platelet procoagulant activity in type 2 diabetes mellitus patients. | Type 2 diabetes mellitus (T2DM) patients have a variable response profile to the P2Y(12) receptor antagonist clopidogrel. P2Y(12) receptor signalling promotes platelet procoagulant activity. The aim of this study was to determine if T2DM patients with suboptimal clopidogrel response have greater platelet procoagulant a... | 19,012,950 |
Calibrated automated thrombin generation and modified thromboelastometry in haemophilia A. | Global coagulation tests may have a better relation with phenotype in haemophilia than traditional coagulation tests. These include the Calibrated Automated Thrombin generation assay (CAT) and modified thromboelastometry using low tissue factor triggering. Both have shown marked variability in thrombin generation and c... | 19,012,951 |
HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. | In the Step Study, the MRKAd5 HIV-1 gag/pol/nef vaccine did not reduce plasma viraemia after infection, and HIV-1 incidence was higher in vaccine-treated than in placebo-treated men with pre-existing adenovirus serotype 5 (Ad5) immunity. We assessed vaccine-induced immunity and its potential contributions to infection ... | 19,012,957 |
Methods for siRNA-mediated reduction of mRNA and protein expression in human placental explants, isolated primary cells and cell lines. | The use of RNA interference (RNAi) to deplete individual proteins from cells or tissue has revolutionised our ability to characterise gene function. The placenta is an attractive target for studies in which the role of specific proteins can be compared with cell culture models and explanted villous tissue where physiol... | 19,012,963 |
Management of suprastomal tracheal fibroma: introduction of a new technique and comparison with other techniques. | Suprastomal tracheal granuloma/fibroma (SSTGF) is a common cause of failure to decannulate following pediatric tracheostomy. Because larger lesions obstruct the trachea, it is necessary to remove them prior to decannulation. Various methods have been described for the management of these obstructing tracheal lesions, i... | 19,012,974 |
Inter-fraction motion and dosimetric consequences during breast intensity-modulated radiotherapy (IMRT). | Intensity-modulated radiotherapy (IMRT) can improve dose homogeneity within the breast planned target volume (PTV), but may be more susceptible to patient/organ motion than standard tangential radiotherapy (RT). We used daily cone-beam CT (CBCT) imaging to assess inter-fraction motion during breast IMRT and its subsequ... | 19,012,980 |
Dyspnea evolution after high-dose radiotherapy in patients with non-small cell lung cancer. | To determine what the influence is of dyspnea (CTCAE3.0) before high-dose radiotherapy (RT) on the incidence and severity of subsequent lung toxicity in patients with non-small cell lung cancer (NSCLC). In 197 patients with stage I-III NSCLC maximal dyspnea scores (CTCAE3.0) were obtained prospectively at three time pe... | 19,012,981 |
Removal of Cr3+ from aqueous solution by biosorption with aerobic granules. | Aerobic granules were utilized as an effective biosorbent to remove Cr(3+) from aqueous solution. The results showed that the initial pH, contact time, and Cr(3+) concentration affected the biosorption process significantly. Both Freundlich and Langmuir isotherms were able to describe the equilibrium data reasonably wi... | 19,013,022 |
Fetal superior mesenteric artery: longitudinal reference ranges and evidence of regulatory link to portal liver circulation. | To establish longitudinal reference ranges for the fetal superior mesenteric artery (SMA) flow velocity and pulsatility index (PI(SMA)). Also to examine the hemodynamic relationship to venous liver perfusion and umbilical flow distribution in the liver, to other splanchnic arteries, and more generally to the middle cer... | 19,013,030 |
[Fulminant myocarditis: clinical value of extracorporeal life support]. | Fulminant myocarditis is a rare cause of cardiogenic shock which usually occurs in young adults without known cardiac disease. Initial course may be complicated by a cardiogenic shock refractory to optimal medical treatment. Temporary circulatory assistance using an extracorporeal life support is of great clinical valu... | 19,013,051 |
[Arteriovenous difference in O2 content, pulmonary venous O2 saturation, cardiac index: are they equivalent in cardiac surgery?]. | To study the concordance of cardiac index (CI), mixed venous oxygen saturation (SvO(2)) and the arterial-mixed venous O(2) content difference, i.e.: C(a-v)O(2), postoperatively to cardiac surgery. We hypothesized that significant discrepancies would be measurable between C(a-v)O(2) and SvO(2), and CI, because the latte... | 19,013,053 |
MicroRNA processing pathway regulates olfactory neuron morphogenesis. | The microRNA (miRNA) processing pathway produces miRNAs as posttranscriptional regulators of gene expression. The nuclear RNase III Drosha catalyzes the first processing step together with the dsRNA binding protein DGCR8/Pasha generating pre-miRNAs [1, 2]. The next cleavage employs the cytoplasmic RNase III Dicer produ... | 19,013,069 |
Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. | Recent studies demonstrated that inhibition of dimethylarginine dimethylaminohydrolase (DDAH) activity could be a new strategy to indirectly affect nitric oxide (NO) formation by elevating N(omega)-methylated L-arginine (NMMA, ADMA) levels. This approach is an alternate strategy for the treatment of diseases associated... | 19,013,076 |
Don't 'leaf' now. The making of a fruit. | The fruit of Arabidopsis thaliana is derived from two fused carpels in the centre of the developing flower. Significant progress has been made in the study of Arabidopsis gynoecium and fruit development during the past few years with the identification of key regulators and analysis of the interactions between them. Ma... | 19,013,099 |
Transcription factor Yin Yang 1 represses fetal troponin I gene expression in neonatal myocardial cells. | Yin Yang 1 (YY1) is a transcription factor that can activate or repress expression of a variety of genes and is involved in several developmental processes. While some transcription factors are known to modulate skeletal myogenesis, the regulation of fetal troponin I (ssTnI) expression by YY1 in cardiac development has... | 19,013,134 |
BDNF Val66Met polymorphism is associated with unstable angina. | Brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of coronary artery disease (CAD). The human BDNF Val66Met polymorphism has been shown to be associated with altered susceptibility to neuropsychiatric disorders. However it is unknown whether this polymorphism plays a role in cardiovascular dis... | 19,013,140 |
Differences in the temporal expression of regulatory growth factors during choroidal neovascular development. | Although the roles of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF) in pathologic neovascularization have been well characterized in certain tissues, their particular functions and expression patterns in choroidal neovascularization (CNV) have not b... | 19,013,152 |
Lack of relationship between cardiovascular reactivity to mental stress and autonomic modulation of the sinoatrial node in normotensive and hypertensive male subjects. | A cardiovascular over-reactivity to stress may participate in the pathophysiology of hypertension. The aim of this study was to investigate whether baseline indexes of autonomic modulation of heart rate or baroreflex sensitivity were correlated with cardiovascular reactivity to stress. Spectral parameters of RR interva... | 19,013,200 |
Atypical neuroleptic risperidone modulates glial functions in C6 astroglial cells. | Risperidone has demonstrated therapeutic advantages over conventional neuroleptics and offers a valuable emerging option for the treatment of social behavior associated with autistic disorder. Considering the putative involvement of astroglial cells in neuropsychiatric disorders, we investigated the effect of risperido... | 19,013,209 |
Reactive oxygen species production and MAPK activation are implicated in tetrahydrobiopterin-induced SH-SY5Y cell death. | Tetrahydrobiopterin (BH4), an obligatory cofactor for dopamine (DA) synthesis, has been shown to produce reactive oxygen species (ROS) upon its autoxidation and induce selective dopaminergic cell death in many in vivo and in vitro models of Parkinson's disease (PD). The precise molecular mechanisms underlying neuronal ... | 19,013,215 |
Binding of Silurus asotus lectin to Gb3 on Raji cells causes disappearance of membrane-bound form of HSP70. | Heat shock proteins (HSPs) are divided into stress-inducible and constitutive types. Generally, HSP70 (stress inducible) and HSC70 (constitutive) are representative of their types, respectively. From the results of immunocytochemical analysis, both HSP70 and HSC70 were constitutively expressed in globotriaosylceramide ... | 19,013,219 |
Epigenetic states in stem cells. | Whereas embryonic stem cells can differentiate into all cell types of the body, stem cells found in somatic tissues display more restrictive differentiation capacity. The extent of multi-lineage differentiation ability of stem cells is believed to be associated with the potential for expression of developmentally- and ... | 19,013,220 |
Development and characterisation of a new model of rat trophoblasts. | The placenta plays a key role during pregnancy. In vitro models have proven to assess the role of placental transporters in the exchange of nutrients, waste products and the distribution of drugs between the maternal and fetal compartments. Therefore, a primoculture of Wistar rat trophoblasts from the labyrinth zone wa... | 19,013,229 |
Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers. | HOXB13 is a homeodomain protein implicated to play a role in growth arrest in AR (androgen receptor)-negative prostate cancer cells. Expression of HOXB13 is restricted to the AR-expressing prostate cells. In this report, we demonstrate that the HDAC inhibitor NaB (sodium butyrate) was able to induce cell growth arrest ... | 19,013,255 |
Loop II of DNA polymerase beta is important for discrimination during substrate binding. | Loop II of DNA polymerase beta (pol beta) consists of 14 amino acid residues and is highly flexible and solvent exposed. Previous research from our laboratory has shown that this loop is important for polymerase activity and fidelity. In the study presented here, we demonstrate that a shortened five amino acid residue ... | 19,013,261 |
In vitro and in vivo evidence for stimulation of bone resorption by an EP4 receptor agonist and basic fibroblast growth factor: Implications for their efficacy as bone anabolic agents. | Prostaglandin E2 receptor subtype 4 agonists (EP4A) and basic fibroblast growth factor (FGF2) stimulate bone formation, but their effects on bone resorption are controversial. To provide additional insight into the skeletal effects of EP4A and FGF2, their regulation of expression of genes associated with bone formation... | 19,013,265 |
Telomerase reverse transcriptase delays aging in cancer-resistant mice. | Telomerase confers limitless proliferative potential to most human cells through its ability to elongate telomeres, the natural ends of chromosomes, which otherwise would undergo progressive attrition and eventually compromise cell viability. However, the role of telomerase in organismal aging has remained unaddressed,... | 19,013,273 |
Effect of ezetimibe on plasma cholesterol levels, cholesterol absorption, and secretion of biliary cholesterol in laboratory opossums with high and low responses to dietary cholesterol. | Partially inbred lines of laboratory opossums differ in plasma low-density lipoprotein cholesterol concentration and cholesterol absorption on a high-cholesterol diet. The aim of the present studies was to determine whether ezetimibe inhibits cholesterol absorption and eliminates the differences in plasma cholesterol a... | 19,013,286 |
Epidemiology of invasive fungal infection. | Invasive fungal infection is a growing cause of morbidity and mortality in immunosuppressed patients. Furthermore, the use of azole prophylaxis against Candida species has coincided with an increase in the incidence of invasive aspergillosis and infections by other filamentous fungi such as Mucorales. New risk factors ... | 19,013,332 |
Viruses and kidney disease: beyond HIV. | Human immunodeficiency virus (HIV)-infected patients may acquire new viral co-infections; they also may experience the reactivation or worsening of existing viral infections, including active, smoldering, or latent infections. HIV-infected patients may be predisposed to these viral infections owing to immunodeficiency ... | 19,013,331 |
Analysis of iron, zinc, selenium and cadmium in paraffin-embedded prostate tissue specimens using inductively coupled plasma mass-spectrometry. | Formalin-fixed paraffin-embedded (FFPE) tissue specimens represent a valuable and abundant resource of pathologic material for various biomedical studies. In the present study, we report the application of high-resolution inductively coupled mass-spectrometry (ICP-MS) for quantification of Fe, Zn, Se and Cd in FFPE pro... | 19,013,358 |
Effects of long-term zinc supplementation and deprivation on gene expression in human THP-1 mononuclear cells. | Zinc is an essential trace element that is critical for cellular function and structural integrity. It has an important regulatory role in the immune system, in particular in monocytes. To identify the diverse cellular targets and mechanisms of action of zinc in this cell type, we used microarray technology to assess t... | 19,013,360 |
Occult nasal sinus tumours causing oncogenic osteomalacia. | Oncogenic osteomalacia (OOM) is a rare but curable cause of metabolic bone disease. We report 9 patients with OOM, including 2 patients with occult nasal sinus tumours and 1 in whom a progressive increase in the post-operative FGF23 level heralded the development of metastatic pulmonary disease. The median duration of ... | 19,013,380 |
A rational approach to ankle fractures. | Ankle fractures involve a spectrum of injury patterns from simple to complex, such that these injuries are not always "just an ankle fracture." By combining the injury mechanism and the radiographic findings, the surgeon can apply the Lauge-Hansen classification in taking a rational approach to the management of these ... | 19,013,398 |
Inter-observer and intra-observer agreement on interpretation of uroflowmetry curves of kindergarten children. | To evaluate the inter-observer and intra-observer agreement on the interpretation of uroflowmetry curves of children. Healthy kindergarten children were enrolled for evaluation of uroflowmetry. Uroflowmetry curves were classified as bell-shaped, tower, plateau, staccato and interrupted. Only the bell-shaped curves were... | 19,013,411 |
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