title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Ultrasound assisted regioselective sulfonation of aromatic compounds with sulfuric acid. | A simple and convenient methodology for selective sulfonation of aromatic compounds using sulfuric acid under sonication is described. The present methodology shows a considerable enhancement in the reaction rate along with improved selectivity compared with the reactions performed under silent conditions. The effect o... | 19,014,895 |
The formation of argpyrimidine, a methylglyoxal-arginine adduct, in the nucleus of neural cells. | Methylglyoxal (MG) is an endogenous metabolite in glycolysis and forms stable adducts primarily with arginine residues of intracellular proteins. The biological role of this modification in cell function is not known. In the present study, we found that a MG-detoxification enzyme glyoxalase I (GLO1) is mainly expressed... | 19,014,907 |
Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels. | NADP(H)-dependent cytosolic aldo-keto reductases (AKRs) have been added to the group of enzymes which contribute to oxidoreductive conversions of retinoids. Recently, we found that two members from the AKR1B subfamily (AKR1B1 and AKRB10) were active in the reduction of all-trans- and 9-cis-retinaldehyde, with K(m) valu... | 19,014,918 |
Epidemiological association between fasting plasma glucose and shortened APTT. | To investigate the relationship between fasting plasma glucose (FPG) and shortened activated partial thromboplastin time (APTT), an independent risk factor for thrombosis. We analyzed outpatients' results of coagulation tests and FPG. When compared with euglycemic subjects, those with impaired fasting glucose and diabe... | 19,014,926 |
Negative elongation factor NELF controls transcription of immediate early genes in a stimulus-specific manner. | The transcription rate of immediate early genes (IEGs) is controlled directly by transcription elongation factors at the transcription elongation step. Negative elongation factor (NELF) and 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) sensitivity-inducing factor (DSIF) stall RNA polymerase II (pol II) soon af... | 19,014,935 |
Orientobilharzia turkestanicum is a member of Schistosoma genus based on phylogenetic analysis using ribosomal DNA sequences. | In the present study, samples representing Orientobilharzia turkestanicum from cattle, sheep, cashmere goat and goat in Heilongjiang Province, China, were characterized and grouped genetically by sequences of internal transcribed spacer (ITS, including ITS-1 and ITS2) and 28S ribosomal DNA (28S rDNA). The ITS and 28S r... | 19,014,940 |
Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. | Refractory celiac disease (RCD) was recently subdivided into 2 subtypes (RCD I and II) based on a normal or abnormal phenotype of intraepithelial lymphocytes (IELs), respectively. It is not clear, however, if these 2 entities differ in their presentation at diagnosis or long-term outcome. We compared the clinical and b... | 19,014,942 |
SIFamide illustrates the rapid evolution in Arthropod neuropeptide research. | This review is focussed on SIFamide. This neuropeptide was discovered as a result of an extensive purification process, typical for 20th century physiology, of an extract of 350,000 flesh flies. Our knowledge of SIFamide greatly expanded since the first publication in 1996. Describing the minor and major findings on th... | 19,014,945 |
Active school transport, physical activity levels and body weight of children and youth: a systematic review. | Active school transport (AST) may be an important source of children's physical activity (PA). Innovative solutions that increase PA time for children, without putting added pressure on the school curriculum, merit consideration. Before implementing such solutions, it is important to demonstrate that active school tran... | 19,014,963 |
In-tube transfection improves the efficiency of gene transfer in primary neuronal cultures. | To facilitate genetic studies in primary neurons, we analyzed the efficiency of cationic lipid-mediated plasmid DNA transfection using adherent and acutely dissociated neuronal suspensions derived from embryonic mouse cortical tissue. Compared to transfections using adherent cultures, the in-tube procedure enhanced the... | 19,014,969 |
Chronic alcohol treatment in rats alters sleep by fragmenting periods of vigilance cycling in the light period with extended wakenings. | Studies have shown that disturbed sleep produced by chronic alcohol abuse in humans can predict relapse drinking after periods of abstinence. How alcohol produces disturbed sleep remains unknown. In this study we used a novel analysis of sleep to examine the effects of alcohol on sleep patterns in rats. This analysis s... | 19,014,977 |
Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling. | UROtsa cells exposed to 50 nM monomethylarsonous acid [MMA(III)] for 52 wk (MSC52) achieved hyperproliferation, anchorage independent growth, and enhanced tumorgenicity. MMA(III) has been shown to induce reactive oxygen species (ROS), which can lead to activation of signaling cascades causing stress-related proliferati... | 19,014,992 |
Molecular cloning, characterization and expression of two tryptophan hydroxylase (TPH-1 and TPH-2) genes in the hypothalamus of Atlantic croaker: down-regulation after chronic exposure to hypoxia. | Recently we discovered that hypoxia causes marked impairment of reproductive neuroendocrine function in Atlantic croaker, a marine teleost, which is due to a decline in hypothalamic serotonergic activity. As a first step in understanding the molecular responses of the hypothalamic serotonergic system to hypoxia, we clo... | 19,015,006 |
No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapy. | Attention-deficit/hyperactivity disorder (ADHD) is the most frequent psychiatric disorder in children and adolescents and is often treated with methylphenidate (MPH), resulting in MPH exposure in more than 1% of all children in many countries. A 2005 report on cytogenetic effects in peripheral lymphocytes from 12 ADHD ... | 19,015,014 |
Morinda citrifolia Linn (Noni): in vivo and in vitro reproductive toxicology. | Morinda citrifolia Linn (syn. Noni) is a plant widely used as food and medicine worldwide but there are no toxicological tests about this plant focused on reproduction. To investigate possible endocrine activity and toxic effect on the reproductive system of Wistar rats by exposure of aqueous extract of the Morinda cit... | 19,015,020 |
Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7. | Pancreatic fibrosis is the hallmark of chronic pancreatitis, currently an incurable disease. Pancreatitis fibrosis is caused by deposition of extracellular matrix (ECM) and the underlying pathological mechanism remains unclear. In addition to its broad biological activities, TGF-beta is a potent pro-fibrotic factor and... | 19,015,026 |
The roles of the FGF signal in zebrafish embryos analyzed using constitutive activation and dominant-negative suppression of different FGF receptors. | The roles of the FGF family growth factors and their receptors (FGFRs) in zebrafish embryos were examined using variously modified versions of the four FGFR genes (fgfr1-4). Constitutively active forms of all of the examined FGFRs (ca-FGFRs) caused dorsalization, brain caudalization, and secondary axis formation, indic... | 19,015,027 |
Mass spectrometry-based footprinting of protein-protein interactions. | We present a high-resolution mass spectrometric (MS) footprinting method enabling identification of contact amino acids in protein-protein complexes. The method is based on comparing surface topologies of a free protein versus its complex with the binding partner using differential accessibility of small chemical group... | 19,015,031 |
Rejection of pulse related artefact (PRA) from continuous electroencephalographic (EEG) time series recorded during functional magnetic resonance imaging (fMRI) using constraint independent component analysis (cICA). | Rejection of the pulse related artefact (PRA) from electroencephalographic (EEG) time series recorded simultaneously with fMRI data is difficult, particularly during NREM sleep because of the similarities between sleep slow waves and PRA, in both temporal and frequency domains and the need to work with non-averaged dat... | 19,015,033 |
The left amygdala knows fear: laterality in the amygdala response to fearful eyes. | The detection of threat is a role that the amygdala plays well, evidenced by its increased response to fearful faces in human neuroimaging studies. A critical element of the fearful face is an increase in eye white area (EWA), hypothesized to be a significant cue in activating the amygdala. However, another important s... | 19,015,094 |
Ventral frontal cortex in children: morphology, social cognition and femininity/masculinity. | The ventral frontal cortex (VFC) has been shown to differ morphologically between sexes. Social cognition, which many studies demonstrate involves the VFC, also differs between sexes, with females being more adept than males. In a previous study of subregions of the VFC in our lab, in an adult population, size of the s... | 19,015,107 |
Self-reflection across time: cortical midline structures differentiate between present and past selves. | The processing of personal changes across time and the ability to differentiate between representations of present and past selves are crucial for developing a mature sense of identity. In this study, we explored the neural correlates of self-reflection across time using functional magnetic resonance imaging (fMRI). Co... | 19,015,116 |
AutDB: a gene reference resource for autism research. | Recent advances in studies of Autism Spectrum Disorders (ASD) has uncovered many new candidate genes and continues to do so at an accelerated pace. To address the genetic complexity of ASD, we have developed AutDB (http://www.mindspec.org/autdb.html), a publicly available web-portal for on-going collection, manual anno... | 19,015,121 |
A cytoplasmic variant of the KH-type splicing regulatory protein serves as a decay-promoting factor for phosphoglycerate kinase 2 mRNA in murine male germ cells. | Phosphoglycerate kinase 2 (PGK2) is a germ cell-specific protein whose mRNA is translationally regulated in the mammalian testis. Using RNA affinity chromatography with the 3'-untranslated region (UTR) of Pgk2 mRNA and adult testis extracts, several associated proteins including a novel isoform of the AU-rich element R... | 19,015,122 |
Selection of oligonucleotides for whole-genome microarrays with semi-automatic update. | Oligonucleotide microarray probes are designed to match specific transcripts present in databases that are regularly updated. As a consequence probes should be checked every new database release. We thus developed an informatics tool allowing the semi-automatic update of probe collections of long oligonucleotides and a... | 19,015,129 |
Prediction of translation initiation site for microbial genomes with TriTISA. | We report a new and simple method, TriTISA, for accurate prediction of translation initiation site (TIS) of microbial genomes. TriTISA classifies all candidate TISs into three categories based on evolutionary properties, and characterizes them in terms of Markov models. Then, it employs a Bayesian methodology for the s... | 19,015,130 |
Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction. | Clinical studies suggest that intake of omega-3 polyunsaturated fatty acids (omega-3 PUFA) may lower the incidence of heart failure. Dietary supplementation with omega-3 PUFA exerts metabolic and anti-inflammatory effects that could prevent left ventricle (LV) pathology; however, it is unclear whether these effects occ... | 19,015,135 |
Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. | Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and PPi. Although dUTP is a normal intermediate in DNA synthesis, its accumulation and misincorporation into DNA is lethal. Importantly, uracil misincorporation is a mechanism of cytotoxicity induced by fluoropyrimidine che... | 19,015,155 |
Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans. | We investigated the role of somatosensory feedback from locomotor muscles on central motor drive (CMD) and the development of peripheral fatigue during high-intensity endurance exercise. In a double-blind, placebo-controlled design, eight cyclists randomly performed three 5 km time trials: control, interspinous ligamen... | 19,015,193 |
Agonist- and antagonist-induced conformational changes of loop F and their contributions to the rho1 GABA receptor function. | Binding of gamma-aminobutyric acid (GABA) to its receptor initiates a conformational change to open the channel, but the mechanism of the channel activation is not well understood. To this end, we scanned loop F (K210-F227) in the N-terminal domain of the rho1 GABA receptor expressed in Xenopus oocytes using a site-spe... | 19,015,197 |
Adaptation of reactive and voluntary saccades: different patterns of adaptation revealed in the antisaccade task. | Sensorimotor adaptation restores and maintains the accuracy of goal-directed movements. It remains unclear whether these adaptive mechanisms modify actions by controlling peripheral premotor stages that send commands to the effectors and/or earlier processing stages involved in registration of target location. Here, we... | 19,015,199 |
High-density lipoprotein: why all the fuss? | The current search for new treatments to combat coronary heart disease (CHD) is centred on increasing HDL-cholesterol. The failure of the CETP inhibitor torcetrapib may force a rethink. This perspective briefly reviews the antiatherosclerotic properties of HDL and ways HDL-cholesterol concentration can be raised, but a... | 19,015,220 |
Extracting respiratory data from pulse oximeter plethysmogram traces in newborn infants. | To investigate whether valid respiratory data can be extracted from the pulse oximeter plethysmographic (pleth) trace in healthy newborn infants, pleth data were collected from the foot, and respiratory airflow was simultaneously measured using a facemask. The pleth waveform was analysed using fast Fourier transform (F... | 19,015,221 |
Detection of cryptic pathogenic copy number variations and constitutional loss of heterozygosity using high resolution SNP microarray analysis in 117 patients referred for cytogenetic analysis and impact on clinical practice. | Microarray genome analysis is realising its promise for improving detection of genetic abnormalities in individuals with mental retardation and congenital abnormality. Copy number variations (CNVs) are now readily detectable using a variety of platforms and a major challenge is the distinction of pathogenic from ubiqui... | 19,015,223 |
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. | p27(Kip1) is a cyclin-dependent kinase inhibitor that regulates the G(1)/S transition. Increased degradation of p27(Kip1) is associated with cellular transformation. Previous work demonstrated that the ubiquitin ligases KPC1/KPC2 and SCF(Skp2) ubiquitinate p27(Kip1) in G(1) and early S, respectively. The regulation of ... | 19,015,242 |
Characterization of the binding specificity of K88ac and K88ad fimbriae of enterotoxigenic Escherichia coli by constructing K88ac/K88ad chimeric FaeG major subunits. | Enterotoxigenic Escherichia coli (ETEC) strains expressing K88 (F4) fimbriae are the major cause of diarrhea in young pigs. Three antigenic variants of K88 fimbriae (K88ab, K88ac, and K88ad) have been identified among porcine ETEC strains. Each K88 fimbrial variant shows a unique pattern in binding to different recepto... | 19,015,246 |
Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling. | Klebsiella pneumoniae magA (for mucoviscosity-associated gene A) is linked to the pathogenesis of primary pyogenic liver abscess, but the underlying mechanism by which magA increases pathogenicity is not well elucidated. In this study, we investigated the role of the capsular polysaccharides (CPS) in the pathogenesis o... | 19,015,249 |
Rapamycin-induced Gln3 dephosphorylation is insufficient for nuclear localization: Sit4 and PP2A phosphatases are regulated and function differently. | Gln3, the major activator of nitrogen catabolite repression (NCR)-sensitive transcription, is often used as an assay of Tor pathway regulation in Saccharomyces cerevisiae. Gln3 is cytoplasmic in cells cultured with repressive nitrogen sources (Gln) and nuclear with derepressive ones (Pro) or after treating Gln-grown ce... | 19,015,262 |
The genetic basis of hereditary medullary thyroid cancer: clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy. | Medullary thyroid cancer (MTC) may occur either sporadically or on a hereditary basis. Hereditary MTC may be observed with either multiple endocrine neoplasia syndromes (MEN 2A and MEN 2B) or as familial MTC (FMTC). Despite the rarity of these syndromes, early diagnosis is especially important, since MTC is a lethal di... | 19,015,274 |
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. | The roles of autoimmune regulator (Aire) in the expression of the diverse arrays of tissue-restricted antigen (TRA) genes from thymic epithelial cells in the medulla (medullary thymic epithelial cells [mTECs]) and in organization of the thymic microenvironment are enigmatic. We approached this issue by creating a mouse... | 19,015,306 |
TIMs: central regulators of immune responses. | Exhaustion of T cell responses during chronic viral infections has been observed in both mouse and man and has been attributed to up-regulation of PD-1 on the surface of exhausted T cells. In patients with chronic human HIV infection, T cell exhaustion leads to opportunistic infections associated with AIDS. However, no... | 19,015,312 |
RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. | The active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily. Additionally, 1,25(OH)(2)D(3) has several nongenomic effe... | 19,015,318 |
Comparison of the performances of two in-house rapid methods for antitubercular drug susceptibility testing. | Resistance to rifampin (rifampicin), isoniazid, and streptomycin of 69 Mycobacterium tuberculosis isolates was analyzed by an in-house method based on mycobacteriophage D29 and a colorimetric micromethod. Both methods showed sensitivity and specificity values ranging from 93% to 100%. These simple methods offer an opti... | 19,015,333 |
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis. | The efficacy of two mesoionic derivatives (MI-H-H and MI-4-OCH(3)) was evaluated in CBA/J mice infected with Leishmania amazonensis. Treatment with these compounds demonstrated that the MI-4-OCH(3) derivative and the reference drug meglumine antimoniate (Glucantime) presented significant activity relative to an untreat... | 19,015,338 |
Statistical model to evaluate in vivo activities of antimalarial drugs in a Plasmodium cynomolgi-macaque model for Plasmodium vivax malaria. | Preclinical animal models informing antimalarial drug development are scarce. We have used asexual erythrocytic Plasmodium cynomolgi infections of rhesus macaques to model Plasmodium vivax during preclinical development of compounds targeting parasite phospholipid synthesis. Using this malaria model, we accumulated dat... | 19,015,340 |
Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adults. | Ibalizumab (formerly TNX-355) is a humanized monoclonal antibody that binds CD4, the primary receptor for human immunodeficiency virus type 1 (HIV-1), and inhibits the viral entry process. A phase lb multidose study of the safety, pharmacokinetics, and antiviral activity of ibalizumab was conducted with 22 HIV-1-infect... | 19,015,347 |
Activity of levofloxacin alone and in combination with a DnaK inhibitor against gram-negative rods, including levofloxacin-resistant strains. | Synergy time-kill testing of levofloxacin alone and in combination with CHP-105, a representative DnaK inhibitor, against 50 gram-negative rods demonstrated that 34 of the 50 strains tested showed significant synergy between levofloxacin and CHP-105 after 12 h and 24 h. Fourteen of these 34 organisms were quinolone res... | 19,015,359 |
Multistrain virus dynamics with mutations: a global analysis. | We consider within-host virus models with n >or= 2 strains and allow mutation between the strains. If there is no mutation, a Lyapunov function establishes global stability of the steady state corresponding to the fittest strain. For small perturbations, this steady state persists, perhaps with small concentrations ... | 19,015,367 |
Object representations for multiple visual categories overlap in lateral occipital and medial fusiform cortex. | How representations of visual objects are maintained across changes in viewpoint is a central issue in visual perception. Whether neural processes underlying view-invariant recognition involve distinct subregions within extrastriate visual cortex for distinct categories of visual objects remains unresolved. We used eve... | 19,015,371 |
B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome. | The diagnosis of chronic lymphocytic leukemia (CLL) in asymptomatic patients has historically been based on documenting a characteristic lymphocyte clone and the presence of lymphocytosis. There are minimal data regarding which lymphocyte parameter (absolute lymphocyte count [ALC] or B-cell count) and what threshold sh... | 19,015,397 |
The angular branch: maximizing the scapular pedicle in head and neck reconstruction. | To evaluate the scapular free flap based on the angular artery in complex head and neck reconstruction. Case series. A tertiary referral center. A series of 25 osteocutaneous scapular flaps was performed from August 2000 through January 2005. Of these 25 flaps, 7 procedures of scapular bone solely vascularized by the a... | 19,015,454 |
Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer. | To investigate if loss of extracellular matrix metalloprotease inducer (EMMPRIN) will inhibit the growth of head and neck squamous cell carcinoma (HNSCC) tumor cell lines in vivo. Tumor cell-derived EMMPRIN is highly overexpressed in HNSCC and is thought to be induced by surrounding fibroblasts to stimulate matrix meta... | 19,015,455 |
Gastrointestinal tract recovery in patients undergoing bowel resection: results of a randomized trial of alvimopan and placebo with a standardized accelerated postoperative care pathway. | To investigate the efficacy and safety of alvimopan, 12 mg, administered orally 30 to 90 minutes preoperatively and twice daily postoperatively in conjunction with a standardized accelerated postoperative care pathway for managing postoperative ileus after bowel resection. This multicenter, randomized, placebo-controll... | 19,015,469 |
Nipple-sparing mastectomy update: one hundred forty-nine procedures and clinical outcomes. | To describe our experience with patients who underwent the nipple-sparing mastectomy procedure developed and standardized at our institution and to report clinical outcomes for those patients with a breast cancer diagnosis. Prospective study for consecutive nipple-sparing mastectomy procedures. Multidisciplinary breast... | 19,015,470 |
GM1/GalNAc-GD1a complex: a target for pure motor Guillain-Barre syndrome. | GM1 and GalNAc-GD1a are located on the axolemma of the motor nerves and are believed to be the antigens associated with pure motor Guillain-Barré syndrome (GBS). Furthermore, GM1 and GalNAc-GD1a may exist nearby and colocalize on the axolemma. Ganglioside complex (GSC) antigens associated with GM1 or GalNAc-GD1a can be... | 19,015,484 |
Early-onset dementia with prolonged occipital seizures: an atypical case of Kufs disease. | Kufs disease is the adult-onset form of neuronal ceroid lipofuscinosis (NCL). Its two clinical phenotypes are type A (progressive myoclonus epilepsy with dementia) and type B (behavioral abnormalities and dementia, associated with pyramidal and extrapyramidal signs). We describe the clinical evolution of an atypical ca... | 19,015,486 |
Perceptual representations in false recognition and priming of pictures. | Using a new procedure, we investigate whether imagination can induce false memory by creating a perceptual representation. Participants studied pictures and words with and without an imagery task and at test performed both a direct recognition test and an indirect perceptual identification test on pictorial stimuli. Co... | 19,015,501 |
Exploring knotting mechanisms in protein folding. | One of the most striking topological features to be found in a protein is that of a distinct knot formed by the path of the polypeptide backbone. Such knotted structures represent some of the smallest "self-tying" knots observed in Nature. Proteins containing a knot deep within their structure add an extra complication... | 19,015,517 |
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. | The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a represso... | 19,015,525 |
Orthology, function and evolution of accessory gland proteins in the Drosophila repleta group. | The accessory gland proteins (Acps) of Drosophila have become a model for the study of reproductive protein evolution. A major step in the study of Acps is to identify biological causes and consequences of the observed patterns of molecular evolution by comparing species groups with different biology. Here we character... | 19,015,541 |
A high-density single nucleotide polymorphism map for Neurospora crassa. | We report the discovery and validation of a set of single nucleotide polymorphisms (SNPs) between the reference Neurospora crassa strain Oak Ridge and the Mauriceville strain (FGSC 2555), of sufficient density to allow fine mapping of most loci. Sequencing of Mauriceville cDNAs and alignment to the completed genomic se... | 19,015,548 |
Metabolic Syndrome and the Risk of Ischemic Heart Disease and Stroke among Middle-Aged Japanese. | Limited information is available regarding risk of cardiovascular disease and trends for the metabolic syndrome in Asia. We examined the impact of the metabolic syndrome and its components on risk of cardiovascular disease among middle-aged Japanese according to four criteria. We followed 2,613 subjects from a rural Ja... | 19,015,596 |
Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects. | Recent studies suggest that lipocalin-type prostaglandin (PG) D synthase (L-PGDS), which converts PGH2 to PGD2, is implicated in the pathogenesis of atherosclerosis. However, clinical evidence for the association between serum L-PGDS levels and atherosclerosis has not been reported. In this study, we measured the serum... | 19,015,601 |
Superior vena cava syndrome caused by an intravascular thrombosis due to underlying prostate carcinoma. | Superior vena cava (SVC) syndrome is usually caused by malignant tumors or their lymph node metastases oppressing a SVC. However, we encountered a case of SVC syndrome that was caused by a thrombus in the SVC, which we considered as a manifestation of Trousseau's syndrome triggered by underlying prostate cancer. A 60-y... | 19,015,618 |
Synthesis and structure of new 3,3,9,9-tetrasubstituted-2,4,8,10-tetraoxaspiro[5.5]undecane derivatives. | The configurational and conformational behavior of some new 3,3,9,9-tetrasubstituted-2,4,8,10-tetraoxaspiro[5.5]undecane derivatives with axial chirality was investigated by conformational analysis and variable temperature NMR experiments. | 19,015,624 |
PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage. | The promyelocytic leukemia (PML) tumor suppressor protein, a central regulator of cell proliferation and apoptosis, is frequently fused to the retinoic acid receptor-alpha (RARalpha) in acute PML. Here we show the interaction of PML with another tumor suppressor protein, the serine/threonine kinase homeodomain-interact... | 19,015,637 |
Predicting the ideal serum creatinine level following kidney transplantation. | This Practice Point commentary reviews a study by Sberro et al. that evaluated formulae to predict the lowest measured serum creatinine concentration in kidney transplant recipients following surgery. The objective of the study was to ascertain a simple means of identifying patients with inappropriately high serum crea... | 19,015,653 |
Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss. | To evaluate the rate of remission of metabolic syndrome (Met Syn) among patients undergoing a brief, low-calorie lifestyle change weight loss intervention and to compare the baseline characteristics of patients who were remitted and not remitted from Met Syn at post-treatment. Obese adults (N=36) meeting criteria for M... | 19,015,662 |
Fundamental-mode cutoff in liquid-filled Y-shaped microstructured fibers with Ge-doped core. | We report on the cutoff characteristics of a Ge-doped Y-shaped microstructured fiber in which the holes are filled with a liquid of refractive index higher than silica but lower than the Ge-doped core. It is found that the cutoff wavelength was very sensitive to temperature variations as a result of the refractive inde... | 19,015,673 |
Numerical multiplexing and demultiplexing of digital holographic information for remote reconstruction in amplitude and phase. | We investigate the possibility to multiplexing (Mux) and demultiplexing (de-Mux) numerically digital holograms (DHs) with the aim of optimizing their storage and/or transmission process. The DHs are multiplexed and demultiplexed thanks to the unique property of the digital holography to numerically manage the complex w... | 19,015,690 |
Route to the minimum pulse duration in normal-dispersion fiber lasers. | The factors that control the pulse duration in all-normal-dispersion lasers are identified. To minimize the pulse duration the cavity dispersion should be as small as possible. For fixed dispersion increasing pulse energy leads to shorter pulses with more structured spectra. Experiments performed with ordinary single-m... | 19,015,693 |
Visible photon-avalanche upconversion in Ho3+ singly doped beta-Na(Y1.5Na0.5)F6 under 980 nm excitation. | Visible IR-to-green photon-avalanche upconversion is reported in an Ho3+ singly doped beta-Na(Y1.5Na0.5)F6 crystal under 980 nm excitation. Upconverted green, red, and IR emissions are observed at 540, 645, and 751 nm, respectively. Temporal evolution and excitation power dependent upconversion intensity are measured, ... | 19,015,698 |
Mid-infrared optical combs from a compact amplified Er-doped fiber oscillator. | By means of a difference-frequency-generation (DFG) process driven by a two-branch Er-doped fiber laser at a stabilized 100 MHz repetition rate, broadly tunable pulses from 5 to 12 microm are generated with an unprecedented power level of around 100 microW. The mid-IR pulse train is expected to exhibit an harmonic comb... | 19,015,704 |
Warmer weather linked to tick attack and emergence of severe rickettsioses. | The impact of climate on the vector behaviour of the worldwide dog tick Rhipicephalus sanguineus is a cause of concern. This tick is a vector for life-threatening organisms including Rickettsia rickettsii, the agent of Rocky Mountain spotted fever, R. conorii, the agent of Mediterranean spotted fever, and the ubiquitou... | 19,015,724 |
Self-assembly in monoelaidin aqueous dispersions: direct vesicles to cubosomes transition. | In the present study, synchrotron small-angle X-ray scattering (SAXS) and Cryo-TEM were used to characterize the temperature-induced structural transitions of monoelaidin (ME) aqueous dispersion in the presence of the polymeric stabilizer F127. We prove that the direct transition from vesicles to cubosomes by heating t... | 19,015,726 |
Allele dependent silencing of COL1A2 using small interfering RNAs. | Osteogenesis imperfecta (OI) is generally caused by a dominant mutation in Collagen I, encoded by the genes COL1A1 and COL1A2. To date there is no satisfactory therapy for OI, but inactivation of the mutant allele through small interfering RNAs (siRNA) is a promising approach, as siRNAs targeting each allele of a polym... | 19,015,742 |
An innovative method to evaluate the suture compliance in sealing the surgical wound lips. | The increasing number of surgical procedures performed with local anesthesia, followed by immediate patient discharge from the hospital, emphasizes the need for a tight waterproof suture that is capable of maintaining its tensile strength in the postoperative phase when the wound tumescence, edema due to the anesthetic... | 19,015,745 |
Protective effects of urinary trypsin inhibitor on systemic inflammatory response induced by lipopolysaccharide. | Urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely used in Japan as a drug for patients with acute inflammatory disorders such as disseminated intravascular coagulation (DIC), shock, and pancreatitis. Recent in vitro studies have demonstrated that serine protease inhibitors may have anti-infl... | 19,015,747 |
Hysteroscopic sterilization: history and current methods. | For many practicing obstetrician-gynecologists, tubal ligation was the gold standard by which female sterilization techniques were measured. Yet gynecologic surgeons have simultaneously sought to occlude the fallopian tubes transcervically to avoid discomfort and complications associated with transabdominal approaches.... | 19,015,762 |
The effects of self-aggregation on the vibrational circular dichroism and optical rotation measurements of glycidol. | The noncovalent interactions between glycidol molecules in the CDCl3 solvent have been studied by means of vibrational absorption (VA), vibrational circular dichroism (VCD), optical rotation (OR) spectroscopy and density functional theory (DFT) calculations. The concentration dependence of the VA and VCD spectra and OR... | 19,015,782 |
Anatomical study of the greater palatine artery and related structures of the palatal vault: considerations for palate as the subepithelial connective tissue graft donor site. | Palate is considered as a tissue graft donor site for dental surgical procedures. Therefore, the aim of this study was to investigate the anatomy of palatal structures, such as greater palatine artery, greater palatine foramen, and incisive fossa, in order to consider their topography at planning the graft dimensions a... | 19,015,806 |
Culturable bacteria in glacial meltwater at 6,350 m on the East Rongbuk Glacier, Mount Everest. | Culturable bacteria in the glacial meltwater in the ablation zones of glacier at high altitude (6,350 m) on Mt Everest were isolated and identified by 16S rRNA amplification and sequencing. The obtained sequences revealed the presence of members of alpha, beta, and gamma-Proteobacteria, Actinobacteria, and Firmicutes, ... | 19,015,814 |
Cloning, sequence analysis, and expression of a gene encoding Chromobacterium sp. DS-1 cholesterol oxidase. | Chromobacterium sp. strain DS-1 produces an extracellular cholesterol oxidase that is very stable at high temperatures and in the presence of organic solvents and detergents. In this study, we cloned and sequenced the structural gene encoding the cholesterol oxidase. The primary translation product was predicted to be ... | 19,015,844 |
Elementary mode analysis: a useful metabolic pathway analysis tool for characterizing cellular metabolism. | Elementary mode analysis is a useful metabolic pathway analysis tool to identify the structure of a metabolic network that links the cellular phenotype to the corresponding genotype. The analysis can decompose the intricate metabolic network comprised of highly interconnected reactions into uniquely organized pathways.... | 19,015,845 |
Disposition of desipramine, a sensitive cytochrome P450 2D6 substrate, when coadministered with intravenous temsirolimus. | Intravenous (i.v.) temsirolimus, a novel inhibitor of mammalian target of rapamycin (mTOR), is approved for treatment of renal cell carcinoma. In vitro studies with pooled human liver microsomes showed that temsirolimus and its principal metabolite, sirolimus, inhibit the CYP2D6 isozyme (K(i) = 1.5 and 5 microM, respec... | 19,015,855 |
Protamine-mediated DNA coating remarkably improves bombardment transformation efficiency in plant cells. | We have developed a method by which remarkably higher efficiencies of transient and stable transformation were achieved in bombardment transformation of plants. Over fivefold increase in transient gus gene expression was achieved when rice or maize suspension cells were bombarded with gold particles coated with plasmid... | 19,015,859 |
Effects of low ambient temperature on heart rate variability during sleep in humans. | The effects of cold exposure on heart rate variability (HRV) during sleep were examined. Eight male subjects slept under three different conditions: 3 degrees C, 50-80% relative humidity (RH) [3]; 10 degrees C, 50% RH [10]; and 17 degrees C 50% RH [17]. No significant differences were observed in HRV during rapid eye m... | 19,015,871 |
Frequent inactivation of RUNX3 by promoter hypermethylation and protein mislocalization in oral squamous cell carcinomas. | RUNX3 is a functionally important component in transforming growth factor-beta (TGF-beta) mediated signaling pathway. Epigenetic silencing expression of RUNX3, as well as aberrant cytoplasmic retention of RUNX3 protein are causally involved in gastric carcinogenesis. Here, we examined the expression of RUNX3 gene and p... | 19,015,875 |
Community use of the amplatzer atrial septal defect occluder: results of the multicenter MAGIC atrial septal defect study. | The objective of this study was to determine the initial safety and results of unrestricted multi-institution routine community use of the Amplatzer Septal Occluder (ASO) for atrial septal defect (ASD) closure. A multicenter, nonrandomized prospective study was performed in 13 pediatric cardiology centers from November... | 19,015,911 |
Accelerated ageing: from mechanism to therapy through animal models. | Ageing research benefits from the study of accelerated ageing syndromes such as Hutchinson-Gilford progeria syndrome (HGPS), characterized by the early appearance of symptoms normally associated with advanced age. Most HGPS cases are caused by a mutation in the gene LMNA, which leads to the synthesis of a truncated pre... | 19,015,945 |
Analysis of vibroarthrographic signals with features related to signal variability and radial-basis functions. | Knee-joint sounds or vibroarthrographic (VAG) signals contain diagnostic information related to the roughness, softening, breakdown, or the state of lubrication of the articular cartilage surfaces. Objective analysis of VAG signals provides features for pattern analysis, classification, and noninvasive diagnosis of kne... | 19,015,987 |
Clinical and epidemiological characteristics of thyroid hemiagenesis: ultrasound screening in patients with thyroid disease and normal population. | Thyroid hemiagenesis is a rare form of thyroid dysgenesis, in which one thyroid lobe fails to develop. The true prevalence of this rare abnormality is about 0.05-0.2% in normal population. We aimed to determine prevalence of thyroid hemiagenesis in patients with various thyroid disorders and a normal population in a mi... | 19,016,002 |
What is (still not) known of the mechanism by which electroporation mediates gene transfer and expression in cells and tissues. | Cell membranes can be transiently permeabilized under application of electric pulses. This treatment allows hydrophilic therapeutic molecules, such as anticancer drugs and DNA, to enter into cells and tissues. This process, called electropermeabilization or electroporation, has been rapidly developed over the last deca... | 19,016,008 |
Epidermal growth factor receptor as a predictor of tumor response to preoperative chemoradiation in locally advanced gastric carcinoma. | The purpose of our study was a retrospective evaluation whether the intensity of epidermal growth factor receptor (EGFR) expression predicts tumor response to preoperative chemoradiotherapy in patients with locally advanced gastric carcinoma. Thirty-six patients with gastric adenocarcinoma (cT2-4 or N+) were studied. P... | 19,016,018 |
[Local recurrence following hepatic radiofrequency ablation: diagnosis and treatment]. | Radiofrequency ablation (RFA) is an established treatment in irresectable malignant liver disease. The most severe constraint is re-occurrence at site of ablation. Whereas factors influencing local recurrence rates have been determined, little is known about the timespan within local recurrence (LR) is to be expected, ... | 19,016,019 |
Treatment options for high-risk T1 bladder cancer: status quo and future perspectives of radiochemotherapy. | To review the standards and new developments in diagnosis and management of high-risk T1 bladder cancer with emphasis on the role of radiotherapy (RT) and radiochemotherapy (RCT). A systematic review of the literature on developments in diagnosis and management of high-risk T1 bladder cancer was performed. First transu... | 19,016,022 |
Seed displacements after permanent brachytherapy for prostate cancer in dependence on the prostate level. | To evaluate seed displacements after permanent prostate brachytherapy considering different prostate levels. In 61 patients, postimplant CT scans were performed 1 day and 1 month after an implant with stranded seeds. Seed and prostate surface displacements were determined relative to pelvic bones. Four groups of seed l... | 19,016,041 |
Adipose tissue and skeletal muscle plasticity modulates metabolic health. | Obesity, accumulation of adipose tissue, develops when energy intake exceeds energy expenditure. Adipose tissue is essential for buffering the differences between energy intake and expenditure by accumulating lipids while skeletal muscle is the energy burning machine. Here we adopted the concept that (i) adipose tissue... | 19,016,045 |
Maternal coherence in the Adult Attachment Interview is linked to maternal reminiscing and to children's self concept. | The role of maternal attachment representations in mother-child reminiscing and children's self concept was assessed in a sample of 31 New Zealand mothers and their 5.5-year-old children. Mothers participated in the Adult Attachment Interview (AAI; Main, Goldwyn, & Hesse, 2002) and reminisced about everyday past ev... | 19,016,052 |
Ethylene glycol poisoning presenting with a falsely elevated lactate level. | Early diagnosis of ethylene glycol poisoning is crucial in order to prevent morbidity and mortality. However, diagnosis can sometimes be delayed because of the false elevation of lactate in some chemistry analyzers as a result of the interference of glycolate, a metabolite of ethylene glycol. We present a case of ethyl... | 19,016,054 |
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