title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Injuries of the midtarsal joint. | Injuries involving the midtarsal joint, which are frequently misdiagnosed, have been studied to clarify the mechanism, classification and treatment. The necessity for routine antero-posterior, lateral and oblique radiographs is emphasised. Seventy-one injuries have been classified according to the direction of the defo... | 234,971 | [
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Computer-facilitated nutritional analysis. | A seven-day dietary analysis of 59 students in the dental health profession indicated that their nutrient consumption was generally adequate. A dental health examination indicated excellent oral hygiene. Nevertheless, many students were deficient in specific nutrient categories. Results suggested that computerized nutr... | 234,985 | [
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The effect of pH on radioimmunoassay of LH and FSH. | Freezing and thawing of human serum produces alkaline changes in the pH. Weak buffers were of insufficient capacity to compensate for these pH changes. Thus the effect of serum pH on modified solid-phase and double-antibody radioimmunoassay (RIA) of LH and FSH was studied. Pooled postmenopausal serum standardized again... | 234,997 | [
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Binding of human chorionic gonadotrophin by rat testis: effect of sexual maturation, cryptorchidism and hypophysectomy. | The specific binding of 125I-labelled human chorionic gonadotrophin (HCG) by rat testicular homogenate as compared with isolated Leydig cells differs with respect to total binding capacity but not to the dissociation constant (Kd) as revealed by Scatchard analysis. The maximal binding capacity for [125I]HCG of crude te... | 235,000 | [
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Early cellular events in a systemic graft-vs.-host reaction. II. Autoradiographic estimates of the frequency of donor lymphocytes which respond to each Ag-B-determined antigenic complex. | A graft-vs.-host (GVH) reaction was initiated by the intravenous injection of parental strain (AO) lymphocytes into irradiated (AO times HO)F1 or (AO times DA)F1 hybrids. The proportion of donor T cells which had responded to the F1 hybrid antigens within 24 h was estimated by two methods. (a) Donor lymphocytes were la... | 235,004 | [
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Abnormal intrafusal muscle fibres in myotonic dystrophy: a study using serial sections. | Studies of the extent and complexity of intrafusal muscle fibre splitting in myotonic dystrophy have been carried out in three spindles obtained at muscle biopsy, and in nine spindles found in the lumbrical muscle of a case that came to necropsy. It is suggested that splitting, due to mechanical stresses, leads to a re... | 235,011 | [
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Stereospecific blockage of the alpha adrenergic receptor by substituted 1-aminotetralines. | Certain members of a series of 1-aminotetraline derivatives reversed the epinephrine pressor response in dogs; this effect occurred with the R- but not the S-isomers. Studies with rabbit aortic strips indicated competitive blockade of the alpha adrenergic receptor by the active agents. Receptor protection experiments... | 235,019 | [
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Brain monoamine levels in the cow during oestrus and metoestrus. | Norepinephrine, dopamine, and serotonin concentrations in the hypothalamus and stalk-median eminence were estimated in nine Hereford heifers at the onset of oestrus or 48 hr later. Significant differences in levels of monoamines at these stages of the oestrous cycle were not evident. Norepinephrine levels were similar ... | 235,027 | [
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[Congenital shoulder dysplasia and luxation]. | In connection with the demonstration of their cases the congenital dysplasia and luxation of the shoulder are discussed. The theories in respect of the pathogenesis of this rare clinical picture, the differential diagnosis as well as the therapeutical possibilities are resumed. | 235,049 | [
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[Total luxation of the ankle, without fracture]. | In the 4 and 10 years' material of two Surgical Departments four total luxations of the talus--without fracture--have been observed by the authors. This luxation is a very rare lesion. The authors' cases are described in detail. All patients heald without complications. The Hungarian and foreign literature dealing with... | 235,054 | [
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Use of an angiotensin II antagonist (saralasin) in the recognition of "angiotensinogenic" hypertension;. | The possibility has been explored of using a specific angiotensin ii antagonist, saralasin (P-113, 1-sar-8-ala-angiotensin ii) to recognize patients whose hypertension depends upon excessive angiotensin ii activity. Among 60 hypertensive patients, saralasin infusion reduced blood pressure in 16 "responders," but not i... | 235,090 | [
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A kinetic study in vitro of the reoxidation of interchain disulfide bonds in a human immunoglobulin IgGLk. Correlation between sulfhydryl disappearance and intermediates in covalent assembly of H2L2. | After reduction by dithiothreitol and removal of the reductant by molecular sieve chromatography, the four interchain disulfide bonds of the human IgGlk protein Fro reoxidize in the presence of oxygen and trace metal ions. The six molecular components of the reoxidation--L (light chain), H (heavy chain), HL, H2, H2L, H... | 235,127 | [
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Effects of peridural block: V. Properties, circulatory effects, and blood levels of etidocaine and lidocaine. | Ten healthy, unpremedicated, male volunteers, aged 21-33 years, were given 20 ml 1 per cent etidocaine with 5 mug/ml epinephrine for peridural analgesia via a catheter placed L2. On a different occasion they were given 20 ml 2 per cent lidocaine with 5 mug/ml epinephrine in the same manner. Initial onset of sensory ana... | 235,229 | [
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[Quantitative method for determining variamycin]. | A quantitative spectrophotmetric method for the assay of variamycin in commercial samples was developed. It was based on the measurement of the optical density of variamycin solutions in 0.01 N hydrochloric acid at a UV spectrum wave length of 412 nm. A method of thin-layer chromatography for a semi-quantitative estima... | 235,239 | [
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Temperature and requency dependence of solvent proton relaxation rates in solutions of manganese(II) carbonic anhydrase. | Longitudinal and transverse proton relaxation rates of water in solutions of manganese(II) bovine carbonic anhydrase have been measured by pulsed nuclear magnetic resonance spectrometry as a function of temperature (2-35 degrees), frequently (5-100 MHz) and pH. The pH dependence of the longitudinal relaxation rate was ... | 235,272 | [
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Dissociation and characterization of enzymes from a multienzyme complex involved in CO2 fixation. | A multienzyme complex from Euglena, molecular weight about 360,000, containing phosphoenolpyruvate carboxylase, malate dehydrogenase, and acetyl-coenzyme A carboxylase has been dissociated into active constituent enzymes. The respective molecular weights are 183,000, 67,000, and 127,000. The malate dehydrogenase contai... | 235,277 | [
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Formaldehyde as a probe of DNA structure. I. Reaction with exocyclic amino groups of DNA bases. | A comprehensive description is given of both the equilibrium and the kinetic aspects of the reaction of formaldehyde with the exocyclic amino groups of derivatives of adenine, cytosine, and guanine; the results extend previous data in the literature to the point where formaldehyde can now be used as a quantitative prob... | 235,285 | [
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Effect of alpha2 macroglobulin on some kinetic parameters of trypsin. | 1. Complex formation of trypsin with alpha2 macroglobulin results in marked changes of the Michaelis-Menten constant, pH optimum and sensitivity to ionic strength in a system using N-carbobenzoxy-glycylglycyl-L-arginine-2-naphthylamide as substrate. 2. In contrasts to the inhibition (50%) observed when alpha2 macroglob... | 235,290 | [
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Effects of a nitrate reductase inactivating enzyme and NAD(P)H on the nitrate reductase from higher plants and Neurospora. | Evidence is presented which suggests that the NAD(P)H-cytochrome c reductase component of nitrate reductase is the main site of action of the inactivating enzyme. When tested on the nitrate reductase (NADH) from the maize root and scutella, the NADH-cytochrome c reductase was inactivated at a greater rate than was the ... | 235,300 | [
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Biosynthesis of acid phosphatase of baker's yeast. Characterization of a protoplast-bound fraction containing precursors of the exo-enzyme. | 1. Yeast protoplasts, secreting acid phosphatase (orthophosphoric-monoester phosphohydrolase (acid optimum) EC 3.1.3.2) contain a small amount of firmly bound enzyme, even after lysis (Van Rijn, H.J.M., Boer, P. and Steyn-Parvé, E.P. (1972) Biochim. Biophys. Acta 268, 431-441). The major part (70%) of this protoplast-b... | 235,303 | [
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Purification and properties of a constitutive beta-lactamase from Pseudomonas aeruginosa strain Dalgleish. | 1. The beta-lactamase (penicillin amido-beta-lactamhydrolase EC 3.5.2.6) appeared to be periplasmic rather than truly intracellular, since it was released by freeze-thawing without gross morphological changes in the cell. 2. The partially purified enzyme had pI between 5.0 and 5.5, mol. wt 32 000 and a broad pH vs acti... | 235,307 | [
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An acridine probe into the physiological state of the cell. | Acridine orange was used as a probe to look into the physiological state of the yeast cell, particularly as regards the change in the properties of the membrane (which acts as a barrier against the incoming acridine orange) and the availability of binding sites for acridine orange in chromosomal DNA during growth. Afte... | 235,310 | [
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[A calorimetric study of the triple helix formation: interaction of poly(C) - guanosine - protonated poly(C)]. | The triple helix formation of poly(C) - guanosine - poly(C+) was investigated by the help of an LKB scanning micro-calorimeter. The existence of the triple helix could also be shown by recording the melting curves. The ultraviolet absorption at different wave lengths namely 275 nm, 260 nm, and 245 nm was plotted as a f... | 235,328 | [
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Fibrinogen ""New York"--an abnormal fibrinogen associated with thromboembolism: functional evaluation. | A 54-yr-old woman presented with a 23-yr history of repeated life-threatening thromboembolism. The presence of a qualitatively abnormal fibrinogen was suggested by the demonstration of delayed and incomplete coagulation of plasma or partially purified fibrinogen by thrombin or Reptilase. Two brothers showed a similar i... | 235,338 | [
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A simple chromatographic method for the determination of the methylated basic amino acids in proteins. | A chromatographic method is described for the determination of epsilon-N-monomethyl-epsilon-N, epsilon-N-dimethyl-, and epsilon-N, epsilon-N, epsilon-N-trimethyllysines, 1-methyl-, and 3-methylhistidines, N-G, N-G-dimethyl-, and N-G, N'G-dimethylarginines, ornithine, the diastereoisomers of hydroxylysine, basic amino a... | 235,351 | [
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Separation of myocardial cytoplasmic acidic inhibitor proteins which inhibit hepatic protein biosynthesis in vitro. | Cytoplasmic inhibitor proteins of rabbit and pig myocardium have been separated and their in-vitro effects on hepatic cell-free protein biosynthesis reported. Three protein peaks could be separated from myocardial cytoplasmic pH 5 fraction by DEAE and CM cellulose column chromatography. There was a difference in the el... | 235,368 | [
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Studies on phosphatidylcholine model membranes. I. Iodine permeability measurement by specific ion electrode. | An iodide specific ion electrode was used to measure iodide released from egg phosphatidylcholine liposomes after passage through an ion exchange column. The permeation process was shown to be a sum of two separate first order processes. The method permits linear initial rates of iodide release to be determined for the... | 235,373 | [
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0.292329... |
Furosemide binding to human albumin and plasma of nephrotic children. | The extent and nature of furosemide (F) binding to human albumin (HA) and to the plasma of 6 children with nephrotic syndrome were studied by equilibrium dialysis at 37 degrees C and pH 7.4 with 14C-F. At a total concentration of 3.4 mug/ml (therapeutic range), the unbound fraction of F to 4 gm per 100 ml HA was 2.79 p... | 235,396 | [
-0.215262,
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0.3597702,
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0.01669277,
0.1921846,
0.1876886,
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-0.0... |
Study of the mechanism of thyroid hormone secretion in an in vitro model system: indirect evidence for fusion of lysosomes with thyroglobulin liposomes. | The interaction between [131I]-thyroglobulin liposomes and thyroidal lysosomes was used as an in vitro model system for analyzing the relation of colloid droplets to lysosomes in follicular cells. The rates of hydrolysis of [131I]-thyroglobulin in a liposome-lysosome system (Lipo-Lyso system) and a thyroglobulin-lysoso... | 235,419 | [
-0.2285337,
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0.2510208,
0.5674413,
0.1224943,
-0.3526651,
... |
[Transfer of glucose from UDP-glucose in microsomal membranes of rat hepatocytes (author's transl)]. | Microsomal preparations from rat liver mediate transfer of glucosyl units from UDP-glucose to three different kinds of acceptors: an endogenous glycoprotein, exogenous glycogen and collagen. Both glucosyl transferases work at acidic pH, 6.5 for transfer on endogeneous acceptor and glycogen and at pH 5.5 for transfer on... | 235,431 | [
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0.02416324,
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0.1082351,
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0.06977927,
0.407976,
-0.02353137,
-0.117884... |
The central modulatory effect of clonidine on the cardiodepressor reflex after suppression of synthesis and storage of noradrenaline. | Rats were decerebrated and treated with a beta-adrenoceptor blocker (toliprolol, Kö 592, 5 mg/kg). Increases of blood pressure were repeatedly elicited by i.v. injection of angiotensin (0.03-0. 125 mug/kg) ant eh accompanying reflex bradycardia was measured. The vagally mediated reflex bradycardia was significantly inc... | 235,438 | [
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0.153266,
0.01036918,
0.3386432,
0.02046563,
0.05143932,
-0.265424,... |
Some properties of cathepsins chemically fixed to carriers. | An insoluble preparation of rat liver cathepsin D was obtained by coupling the enzyme to Enzacryl Polyacetal (EPA-cathepsin) and to CNBr-activated Sepharose 4B. EPA-cathepsin was active toward the synthetic hexapeptides (Gly-Phe-Leu)2 and did not split hemoglobin. The optimum pH of splitting was displaced upward by 1.5... | 235,496 | [
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0.5825189,
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0.2138568,
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0... |
Xanthosine-5'-phosphate amidotransferase from Escherichia coli. | The purified enzyme xanthosine-5'-monophosphate (XMP) aminase from Escherichia coli strain B-96 is shown to possess catalytic activity with either glutamine or ammonia as a substrate. This enzyme, which possesses identical subunits, has the following properties: (a) a pH optimum of 8.3 for both aminase and amidotransfe... | 235,520 | [
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0.1712703,
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0.2871541,
0.2155943,
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0... |
Solvent-temperature perturbations of ionizable groups as a tool for the investigation of the active site of enzymes. | Co-solvent and temperature effects on the pK of histidine (imidazolium) residue 46 of trypsin, as well as of weak electrolytes (buffers), which have been reported in two preceding papers, can be satisfactorily explained in terms of enthalpy-entropy compensation patterns. Such patterns have been generated for various mi... | 235,525 | [
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0.3502733,
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0.1585156,
-0.1507111... |
Characterization of the different polypeptide components and analysis of subunit assembly in ferritin. | Ferritin was dissociated into subunits by various denaturants and the subunits were examined by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Human, horse, rat, and rabbit ferritins all exhibited characteristic patterns of heterogeneity; components with molecular weights of about 19,000, 11,000, and 8,000 ... | 235,540 | [
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0.1177622,
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0.1793851,
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... |
The effects of inositol hexaphosphate on the allosteric properties of two beta-99-substituted abnormal hemoglobins, hemoglobin Yakima and hemoglobin Kempsey. | Hemoglobins (Hb) Yakima and Kempsey were purified from patients' blood with diethylaminoethyl cellulose column chromatography. The oxygen equilibrium curves of the two hemoglobins and the effects of organic phosphates on the function were investigated. In 0.1 M phosphate buffer, Hill's constants n for Hb Yakima and Hb ... | 235,541 | [
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0.6912019,
0.1181117,
0.08927701,
... |
Rabbit liver pyridoxamine (pyridoxine) 5'-phosphate oxidase. Purification and properties. | Pyridoxamine (pyridoxine) 5'-phosphate oxidase (EC 1.4.3.5) has been purified 2000-fold from rabbit liver. The enzyme preparation migrates as a single protein and activity band on analytical disc gels containing 4,7, or 9 percent acrylamide, and as a single protein band on sodium dodecyl sulfate acrylamide gels. The ox... | 235,547 | [
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0.2327567,
0.3845665,
0.09632445,
0.2272164,
0.02048807,
0... |
Red cell NADP+ and NADPH in glucose-6-phosphate dehydrogenase deficiency. | Extraction in the presence of sodium hydroxide and cysteine allows estimates of NADPH and total NADP in human red cells without the erroneously high values of NADP+ obtained with earlier methods. An application of this technique to G6PD-deficient cells reveals that most of the nucleotide is in the oxidized form. In con... | 235,564 | [
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0.1860782,
0.3781219,
0.2872921,
0.2000412,
... |
Monoaminergic mediation of female sexual behavior. | Lordotic behavior was facilitated in estrogen-primed female rats by direct application of progesterone or serotonergic or beta-adrenergic receptor blockers to specific telencephalic, anterior hypothalamic-medial preoptic, or posterior hypothalamic sites. Blockade of the alpha-adrenergic system was ineffective in facili... | 235,573 | [
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... |
[Problem of increasing the viability of the ischemic myocardium in the light of experimental studies]. | With the author's own observations and literature sources as a background the key issues concerned with increasing the viability of the myocardium in acute ischemia are considered. The possibility of a material enlargement of the collateral coronary circulation through administration of mesatonemonoaminoxidase inhibito... | 235,663 | [
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0.5260794,
0.5551438,
0.06074063,
-0.11057... |
[Crocodile tears syndrome]. | Among 245 patients with peripheral facial nerve paralysis in 16 cases gustatory lacrimation was observed to remain as a sequel of paralysis. On the basis of clinical observation, testing of nerve excitability, Schirmer's test, examination of taste and laryngological examinations it was found that gustatory lacrimation ... | 235,748 | [
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0.3761691,
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0.1736357,
0.2166527,
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0.2720142,... |
Life history of Coelomomyces psorophorae. | The mosquito parasite, Coelomomyces psorophorae (Blastocladiales, Chytridiomycetes) alternates obligately between the larvae of Culiseta inornata and the copepod Cyclops vernalis. Isogametes, derived from heterothallic, wall-less gametangia which develop in the copepod, fuse to produce a diploid zygote that subsequentl... | 235,761 | [
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0.3455565,
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0.08455853,
0.2429445,
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-0.... |
Heart transplantation in endotoxin shock. | The condition of the heart from dogs in endotoxin shock was evaluated, and all dogs in the control group receiving 5 milligrams per kilogram to Eschericia coli endotoxin died within two to 14 hours. Hearts from four other dogs receiving the same dosage of endotoxin were allografted orthotopically into healthy recipient... | 235,795 | [
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0.2601745,
0.3474788,
0.1780671... |
Comparative effects of beta adrenergic blocking drugs. | Although many different beta blockers are now in clinical use, there is very little information concerning their relative efficacy, and it is still not clear what clinical importance should be attached to properties such as positive inotropic stimulation (intrinsic sympathomimetic activity or ISA) and membrane stabiliz... | 235,803 | [
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0.3440916,
-0.1275011,
0.07670648,
-0.05692049... |
[Identification of mycoplasmas isolated from monkeys]. | The authors identified 15 strains of mycoplasmae isolated from Papio hamadryas suffering from leukemia and from healthy Macacus rhesus, a green monkey and saimiri. A study was made of their biochemical properties, antigenic properties in the reaction of growth depression with immune sera to a number of standard strains... | 235,821 | [
0.1927737,
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0.1676494,
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0.2439754,
0.4439991,
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... |
Fibrinoid necrosis of liver parenchymal cells. | By means of different histological and histochemical investigations and fluorescence microscopy it has been possible to demonstrate fibrinoid necrosis of parenchymal liver cells in cases of delayed chloroform death and in septic, toxic and infectious hepatitis. This type of necrosis has previously been observed only in... | 235,824 | [
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0.1018994,
0.006739729,
0.3239985,
0.1849166,
-0.00519542,
-0.0874847... |
Double-blind comparison of the effectiveness of azathioprine and sulfasalazine in idiopathic proctocolitis. Preliminary report. | A double-blind therapeutic trial of azathioprine in 20 patients with acute proctocolitis was performed over a 3-month period. Azathioprine was compared with sulfasalazine in patients paired and treated in a sequential order. Clinical, laboratory, endoscopic, biopsy, and radiologic data were assessed by semiquantitative... | 235,835 | [
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0.1293512,
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-0.01106608,
-0.132712... |
Aqueous humor pH changes after experimental alkali burns. | Following application of 2N sodium hydroxide, or 8.1N ammonium hydroxide to rabbit cornea, the aqueous humor pH reached a maximum of 10.2, 11.9, and 12 within six minutes following 20-, 50-, and 100-mu1 sodium hydroxide burns, respectively; after two hours the pH had fallen to 8.5, 10, and 10.5. The maximum rise follow... | 235,843 | [
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0.2257821,
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0.3717614,
0.3121345,
0.187016... |
Electrostatic effects in myoglobin. Application of the modified Tanford-Kirkwood theory to myoglobins from horse, California grey whale, harbor seal, and California sea lion. | The modified Tanford-Kirkwood electrostatic theory (Shire et al., 1974a) was applied to ferrimyoglobins from the following animal species: sperm whale (Physeter catodon), horse, California grey whale (Eschrichtius gibbosus), harbor seal (Phoca vitulina), and California sea lion (Zalophus californianus). Computations we... | 235,950 | [
0.1282397,
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0.09332412,
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0.4264861,
-0.03898276,
0.05899276,... |
Magnetic circular dichroic spectra of cobalt(II) substituted metalloenzymes. | The magnetic circular dichroic (MCD) spectra of cobalt(II) sugstituted metalloenzymes have been studied and compared to a series of four-, five-, and six-coordinate cobalt(II) model complexes previously examined (T. A. Kaden et al. (1974), Inorg. Chem. 13, 2582). The MCD spectra of cobalt substituted carboxypeptidase A... | 235,952 | [
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0.06958444,
0.1255161,
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0.... |
Interaction of effecting ligands with lac repressor and repressor-operator complex. | The equilibrium association constants for the binding of a wide variety of effecting ligands of the lac repressor were measured by equilibrium dialysis. Also, detailed investigations of the apparent rate of dissociation of repressor-operator comples as a function of ligand concentration were carried out for several ind... | 235,964 | [
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0.2236285,
0.3218077,
0.2557613,
0.1936796,
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0.3192... |
Endoribonuclease from bovine adrenal cortex cytosol. | An endoribonuclease which digests a variety of synthetic homoribopolymers and poly(A)-rich mRNA has been identified and purified greater than 500-fold with respect to specific activity from bovine adrenal cortex cytosol. Enzymatic digestion of synthetic poly(riboadenylic acid) was stimulated by Mn-2+ and Mg-2+ and the ... | 235,972 | [
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-... |
The effect of o-phenanthroline on the midpoint potential of the primary electron acceptor of photosystem II. | The primary electron acceptor of Photosystem II has a midpoint oxidation-reduction potential of +95 mV at pH 7.0 in Photosystem II chloroplast fragments prepared by digitonin treatment. The midpoint potential of the acceptor has a pH dependence of -60 mV/pH unit. At concentrations that inhibit oxygen evolution, o-phena... | 235,986 | [
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0.1493521,
0.2011469,
0.2588... |
Studies on acetylcholinesterase and cholinesterase covalently bound to polymaleinic anhydride. | Acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) and cholinesterase (acylcholine acylhydrolase, EC 3.1.1.8), respectively, were covalently attached to a cross-linked copolymerisate of maleinic anhydride and butanediol-divinylether. Based on the coupling procedure reported by Brümmer et al. (Brummer, W., Hennr... | 235,987 | [
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-0.13173,
-0.245... |
L-ascorbic acid 2-sulphate. A substrate for mammalian arylsulphatases. | Ascorbic acid 2-sulphate has a stability in acid comparable to that of phenyl sulphate and is rather more acid-labile than simple carbohydrate sulphates. At its optimum pH of 4.8 sulphatase A(aryl-sulphate sulphohydrolase EC 3.1.6.1.) hydrolyses ascorbic acid sulphate with a specific activity of 90 mumol/mg per min (15... | 235,988 | [
-0.3227465,
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0.01419448,
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0.1666049,
0.1505844,
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0.1920027,
0.1231852,
0.1878433,
0.1533708,
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-0.3988633,
-... |
Glycolysis in human erythrocytes containing elevated concentrations of 2, 3-P2-glycerate. | In studies on the mechanism of the inhibitory effect of 2, 3-diphosphoglycerate on glycolysis in human erythrocytes, the following results were obtained: 1) Glucose consumption and lactate production are reduced by 70 and 40 per cent relative to normal erythrocytes in red blood cells containing five times the normal am... | 236,004 | [
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0.09034668,
0.1103824,
0.2493202,
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0.1210535,
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0.2766319,
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0.4172257,
0.1850042,
0.2208851,
0.4100258,
0.2634941,
0.01436452,
... |
Studies on the mechanism of metabolic stimulation in polymorphonuclear leucocytes during phagocytosis. I. Evidence for superoxide anion involvement in the oxidation of NADPH2. | 1. The oxidation of NADPH2 by leucocyte granules, as measured at acid pH in the presence of Mn-2+, was found to be inhibited by superoxide dismutase. 2. Omission of Mn-2+ markedly lowered the oxidase activity at acid pH, which was still inhibited by superoxide dismutase. 3. At alkaline pH the oxidase activity was lower... | 236,010 | [
-0.004363991,
0.007713281,
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0.2319432,
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0.04989799,
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0.02732081,
0.2799675,
0.2440364,
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0.06997155,
0.1437852,
0.4032289,
0.2361969,
0.07165252,
0.0876316... |
On the stimulation of the light-induced proton uptake by uncoupling aminoacridine derivatives in spinach chloroplasts. | 1. Light-induced proton uptake by spinach chloroplasts is enhanced several-fold by 9-(4-diethylamino-1-methylbutylamino)-6-chloro-2-methoxyacridine (atebrin). This stimulation does not depend on the chlorophyll concentration. The amount of extra protons taken up in the presence of atebrin is determined by the pKa val... | 236,030 | [
-0.3045639,
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0.1913822,
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0.3962656,
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0.07202814,
0.04575884,
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0.3160525,
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-0.0006464305,
0.592859,
-0.03413746,
0.2056... |
Phospholipase A activities in rat placentas of 14 days' gestation. | 1. Homogenates and subcellular fractions of placentas obtained from rats on the 14th day of gestation were assayed for enzymes characteristic of various subcellular organelles. Based on these assays it seemed the placental lysosomes (acid phosphatase activity) were distributed equally among the subcellular particulate ... | 236,032 | [
0.04084851,
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0.2786623,
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0.01839294,
0.3431739,
0.3646308,
0.3919126,
0.4175299,
-0.1362028,
0.14... |
Metabolism of alkyldihydroxyacetone phosphate in rat brain. | Alkyldihydroxyacetone-P is the first detectable product in the biosynthetic pathway for ether-linked glycerolipids that eventually leads to the formation of ethanolamine plasmalogens, a major constituent of myelin. During early postnatal development, the specific activity of NADPH2:alkyldihydroxyacetone-P oxidoreductas... | 236,033 | [
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0.08975445,
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0.1671171,
0.4290718,
0.2839266,
0.01882741,
0... |
The control of pyruvate kinases of Escherichia coli. II. Effectors and regulatory properties of the enzyme activated by ribose 5-phosphate. | The pyruvate kinases of Escherichia coli activated by ribose 5-phosphate (RP) has been partially purified. The active form of the enzyme has a molecular weight of about 180 000 as judged by sucrose density gradient centrifugations and Sephadex G-150 chromatography. On dissociation in the absence of sulfhydryl reagents ... | 236,081 | [
-0.04725892,
0.1069384,
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0.05159584,
0.1230808,
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0.173055,
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0.2727947,
0.09191425,
-0.08885572,... |
In situ studies on the effect of acid extraction on the DNA template activity of mature avian erythrocytes. | Exogenous E. coli RNA polymerase was used to determine the in situ DNA template activity of ethanol/acetone fixed avian erythrocytes. No RNA polymerase-catalyzed incorporation of 3H-UTP was detected in mature avian erythrocytes while simultaneously fixed avian lymphocytes did exhibit incorporation of 3H-UTP. Nuclei of ... | 236,093 | [
0.082594,
0.1291561,
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0.1684558,
0.2717032,
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0.2998899,
0.285973,
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0.1618182,
0.3832289,
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-0.3594132,
-0.1827... |
An automated technique for the analysis of plasma guanidino acids, and some findings in chronic renal disease. | A sensitive method for the quantitative determination of all guanidino compounds in human serum, including basic compounds such as methylguanidine, was developed by the adaptation of the Technicon automatic amino acid analyzer. Elution buffers with very high pH and molarity are employed for the elution of very basic co... | 236,102 | [
-0.08240469,
0.1326912,
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0.1304405,
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0.02458315,
0.02979733,
0.06678931,
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0.4056706,
0.5142497,
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0.2716252,
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0.2850436,
0.04287871,
-0.03554281,
-0.06082... |
Linkage investigation of a large family with Reifenstein's syndrome. | Linkage analysis of a 116-member family with 11 males affected by Reifenstein's syndrome is reported. One X-chromosomal and eight autosomal markers were used. Close linkage can be excluded for P, K, MNS and Xg-a. A possibility of close linkage to ABO is discussed. | 236,106 | [
0.2191929,
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0.083824,
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0.07982484,
0.08947583,
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0.2966114,
-0.200718,
-0.1493442,... |
Pathogenesis of lead shot poisoning in the mallard duck. | Adult mallard ducks were administered steel pellets to determine the rate of excretion from the gastrointestinal tract. In separate studies the ducks were administered 5 number 6 lead pellets. Birds were examined for clinical signs and sacrificed at given intervals over a 20 day period to assess changes in tissue struc... | 236,148 | [
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0.07638088,
0.4153133,
0.7234948,
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... |
Reconstitution of the rabbit pulmonary microsomal mixed-function oxidase system from solubilized components. | Lung microsomal cytochrome P-450 was solubilized and purified 2-fold. NADPH-cytochrome c reductase (EC 1.6.2.3) was solubilized and purified 4-6 fold by three methods with use of sonication and detergent digestion followed by either DEAE-cellulose chromatography or ammonium sulfate fractionation. Benzphetamine N-demeth... | 236,158 | [
-0.001347339,
0.2124465,
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0.009802546,
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0.007740018,
0.2075926,
0.2314748,
0.2349671,
0.1010955,
-0.06924314... |
Biliary excretion of diphenylhydantoin in the rat. Time-course studies. | The role of biliary excretion in the dose-dependent elimination of diphenylhydantoin (DPH) was investigated in the rat. During 6 hr, following iv injection of 10 mg of (14-C)DPH per kg, 28% of the radioactivity was excreted in bile and following the higher dose of DPH reached a plateau and remained constant over a peri... | 236,160 | [
-0.3720609,
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0.3081593,
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0.005456465,
0.006197812,
0.09227451,
0.05355047,
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0.2484187,
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0.2009342,
0.07125491,
0.5750235,
0.1979177,
... |
Hydroxylation of 14-C-niflumic acid by phenobarbital-induced rat liver microsomes. | Hydroxylation of niflumic acid to 4'-hydroxyniflumic acid and 5-hydroxyniflumic acid by rat liver microsomes from untreated animals or phenobarbital-pretreated animals has been demonstrated. Pretreatment of rats with phenobarbital (50 mg/kg) increased the 4'-hydroxylase activity 53%, whreas the 5-hydroxylase activity w... | 236,165 | [
-0.09308732,
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0.2441502,
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0.1300819,
0.3369868,
0.1162344,
0.3162532,
-0.1063846,
... |
Renal glutaminase in postnatal and adult rats. | Properties of renal phosphate-dependent glutaminase (EC 3.5.1.2), assayed in tissue homogenates, were compared in adult, 2-week-old, and newborn rats. Vmax, Km glutamine, pH optimum, inhibition by glutamate, activation by phosphate, intracellular distribution, and the possible presence of activators or inhibitors were ... | 236,175 | [
-0.06170297,
0.01362227,
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0.2807464,
0.3395483,
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0.4029822,
0.01926763,
0.2626086,
0.3366323,
0.5095969,
-0.01151028... |
Effect of magnesium ion (Mg2+) and the magnesium adenosine triphosphate ion (MgATP2-) on pigeon liver pyruvate carboxylase. | Kinetic methods have been used to determine whether Mg2+ and MgATP2- play an important role in regulating pigeon liver pyruvate carboxylase [pyruvate: CO2 ligase (ADP), EC 6.4.1.1]. Mg2+ not only forms a complex with ATP4- (MgATP2-) but is also required for the enzyme activation (and probably for the binding of MgATP2-... | 236,182 | [
-0.3272319,
0.218325,
-0.54089,
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0.1291536,
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0.07609005,
0.1999256,
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0.02394444,
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0.07691124,
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0.1604147,
0.4362598,
0.2178864,
-0.02019141,
0.1... |
Dibenamine blockade on gastric acid secretion in vitro and its protection by histamine antagonists. | Experiments to protect the histamine receptor against dibenamine blockade were carried out to elucidate the pharmacological characteristics of the H2-histamine receptor system for gastric acid secretion in isolated bullfrog gastric mucosa. Dibenamine alone (5 times 10-minus 5 g/ml) irreversibly blocked both basal and h... | 236,188 | [
0.04684174,
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0.4827391,
0.1404888,
0.0737579,
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0.1543622,
0.2131438,
0.1468976,
0.2264431,
0.1809158,
0.04536577,
-0.06... |
Influence of the adrenal gland on the pressor effect and antagonistic potency of angiotensin II analogs. | In ganglion blocked vagotomized rats, several 1,8-substituted angiotensin II analogs (250 ng/kg/min, i.v.) antagonized the pressor effect of angiotensin II. Dose ratios measured at the ED20 levels were: [Sar1,Ile8]-28; [Gac1,Ile8]- 19;[MeAla1,Ile8i1- 16;[MeIle1,Ile8]- 10;[sar1,Ala8]- 9;[me2Gly1,Ile8]- 4. Elimination of... | 236,194 | [
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0.211032,
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0.2862024,
0.5437308,
0.4962983,
0.3166215,
0.08784461,
0.01259961,
-... |
Isolation of two new related peptide antibiotics, cerexins A and B (studies on antibiotics from the genus Bacillus. I). | Two new antibiotics cerexins A and B were isolated from different strains identified with Bacillus cereus. These two antibiotics are amphoteric in nature, soluble in particular solvents such as dimethylsulfoxide, dimethylformamide and alkaline water, and show typical infrared absorptions of peptide. These also have sim... | 236,271 | [
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0.1173436,
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0.09089831,
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0.00726162,
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0.1930885,
-0.0152396,
-0.1666573,... |
A new flavin enzyme catalyzing the reduction of dihydrodipicolinate in sporulating Bacillus subtilis I. Purification and properties. | A dihydrodipicolinate reductase containing flavin was purified from sporulating Bacillus subtilis PCI 219. The purified enzyme appeared homogeneous by dise gel electrophoresis. Its molecular weight was estimated as 74,000 by gel filtration on Sephadex G-200, and as 18,500 by electrophoresis on sodium dodecylsulfate p... | 236,291 | [
-0.07449053,
0.2910411,
0.06518539,
0.250565,
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0.2336954,
0.3459514,
0.09904777,
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0.30... |
Altered renin release and propranolol potentiation of vasodilatory drug hypotension. | Vasodilating antihypertensive drugs induce hypotension with reflex tachycardia, renin release, and fluid and electrolyte retention. Propranolol can impair this renin release. The studies described here were designed to determine the hemodynamic role of vasodilatory drug-induced renin release and inhibition thereof by p... | 236,325 | [
0.08656005,
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0.1714483,
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0.2769919,
0.1876017,
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-0.2741309,
... |
Indolizines II: search for potential oral hypoglycemic agents. | A few 1,2-bis(N-alkylaminomethyl)indolizines, simple indolizinecarboxylic acids, and several 6-alkoxyindolizine-2-carboxylic acids were synthesized and screened as possible oral hypoglycemic agents. The absence of any significant hypoglycemic activity excludes these compounds from the predicted structural lead provided... | 236,380 | [
-0.3209477,
0.06155427,
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0.3575714,
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0.229389,
0.3485149,
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0.2144626,
0.126152,
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-0.... |
Pyruvate kinase from human skeletal muscle. | A simple method is described for the isolation of crystalline pyruvate kinase from human skeletal muscle. The enzyme was purified by ammonium sulfate fractionation, heat treatment and crystallization. Two crystal forms of pyruvate kinase differing in solubility but not in specific activity were found. The homogenous en... | 236,510 | [
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0.05466832,
0.1884559,
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... |
[Verapamil in the study and treatment of supraventricular tachycardias, with special reference to pre-excitation]. | Verapamil is a novel antiarrhythmic agent which appears to act as a calcium-ion antagonist, blocking calcium transport across the myocardial cell membrane. It was given intravenously, in a dose of 10 mg, to thirty-two patients suffering from paroxysmal supraventricular tachycardia, and sinus rhythm was achieved promptl... | 236,526 | [
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0.3006924,
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0.03779735,
0.1438667,
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-0.2711073,
... |
A double blind trial of nitrazepam and flurazepam as sedatives. | A double-blind cross-over trial was conducted using flurazepam and nitrazepam as sedatives in a group of a dozen psychiatric in-patients. The results show highly significant differences between placebo effects and the active drugs. The differences between the two drugs were not significant apart from the subjective est... | 236,528 | [
-0.2538086,
0.2743136,
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0.1058109,
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0.2689869,
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0.1586848,
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0.1803811,
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0.07060827,
0.03615864,
0.2182788,
-0.04911663,
0... |
The interaction of ribonuclease T 1 with DNA. | The interaction of RNase T1 with calf thymus DNA was studied using uv difference spectroscopy and the effect of the enzyme on DNA melting. There was no indication of RNase T1 binding with native DNA. A prominent difference spectrum for RNase T1 binding with denatured DNA (d-DNA) was observed at pH 5, 25 degrees and low... | 236,550 | [
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0.06492563,
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0.0406172,
0.1319006,
0.3894312,
0.1552236,
-0.05915765,
-0.2182478,... |
Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor. | Studies in cultured fibroblasts from patients with the clinical syndrome of homozygous familial hypercholesterolemia have disclosed two different mutations affecting the functions of the low density lipoprotein receptor. One of these mutations, described previously, results in a functionless receptor that does not bind... | 236,556 | [
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0.01512158,
0.0... |
Metabolism of octanoate and its effect on glucose and palmitate utilization by isolated fat cells. | Octanoate is avidly incorporated into triglycerides by isolated rat adipocytes in the presence of glucose via direct esterification without prior beta-oxidation to acetyl CoA. This was shown by separation of the products formed from (1-14C) octanoate into lipid classes using Florisil columns, and after alkaline hydrol... | 236,573 | [
-0.1502267,
0.101241,
-0.3065365,
0.09834311,
0.1858148,
-0.04493459,
-0.404775,
0.4221956,
-0.07495164,
0.2773616,
-0.1475916,
-0.1818483,
0.1421433,
0.0007145685,
-0.7716303,
0.01620641,
-0.2289867,
0.1138686,
0.05769843,
0.3923762,
-0.02939564,
0.2439529,
-0.3510242,
... |
Evidence for beneficial effect of intravenous glucose on the hemodynamic response to acute asphyxia. | Anesthetized rabbits were subjected to two 4-min periods of asphyxia with a 15-min recovery period intervening. During the recovery period animals received an iv infusion of either isotonic glucose or mannitol. Results indicated that glucose had a beneficial effect on systolic blood pressure during the second period of... | 236,574 | [
-0.3402034,
-0.3359177,
-0.3424756,
-0.2980398,
0.1842315,
-0.1610384,
-0.2813688,
-0.1179235,
-0.08513129,
-0.0229484,
0.1310664,
0.01523057,
-0.1698193,
-0.1192833,
-0.2826096,
-0.02067665,
-0.3992426,
0.2580847,
-0.2105683,
-0.1135902,
0.1465402,
0.04812304,
0.01648799... |
Positive chronotropic and inotropic effects of glucagon on the canine isolated atrium. | Effects of glucagon on SA node pacemaker activity and atrial contractility were investigated in isolated canine atrium preparations which were perfused with blood led from a support dog and suspended in a bath. Glucagon at a dose from 0.1 to 10 mug was injected into the sinus node artery, which caused a marked positive... | 236,604 | [
-0.2113601,
-0.1003947,
-0.8085415,
-0.5247064,
-0.09912997,
-0.2519165,
-0.08176353,
-0.2482019,
0.01578762,
-0.2083979,
-0.2953724,
0.1301359,
-0.06623639,
-0.1798859,
-0.2496913,
-0.06779391,
-0.4090326,
0.3667189,
-0.2860841,
0.3929837,
0.2933852,
-0.0555822,
0.042323... |
Cholinergic and adrenergic neuroreceptors in urinary tract of female dogs. Evaluation of function with pharmacodynamics. | Our preliminary pharmacodynamic studies on the lower urinary tract of adult female dogs indicate that cholinergic and adrenergic (alpha and beta) neuroreceptors in the urethra appear to coordinate the detrusor and urethral function during micturition. Urethral resistance measured as urethral pressure was easily alter... | 236,615 | [
-0.02837074,
0.1105119,
-0.2696178,
-0.4182671,
0.02229652,
-0.3910929,
-0.3486162,
-0.3418922,
-0.1479116,
-0.1075435,
0.04948824,
0.009665857,
0.009520777,
0.07393741,
-0.2145889,
0.1331335,
-0.2861345,
0.6748853,
-0.1819739,
-0.07964492,
-0.08952255,
-0.166792,
0.15890... |
Secretion of progesterone by human overies perfused in vitro. | A system for the perfusion of isolated human ovaries is described. Krebs-Ringer bicarbonate buffer (pH 7.4) containing glucose, sodium lactate and pyruvate was perfused at a flow rate of 5-8 ml/min at 37 degrees C through the ovarian artery. Oxygen uptake, LDH-activity, pH and progesterone secretion were determined as ... | 236,628 | [
0.129979,
-0.0174962,
-0.3540529,
0.197783,
-0.0481279,
-0.3178749,
0.2349702,
0.09971971,
-0.3172312,
-0.199226,
0.01840319,
0.05400765,
0.2032704,
-0.2180851,
-0.3946351,
-0.3027889,
-0.246169,
-0.03960902,
-0.05726736,
0.1201478,
0.3086591,
0.1314277,
0.01508205,
0.3... |
Production of cell-bound antigens by Bacteroides fragilis nctc 9343 in continuous culture. | Highly active antigen preparations, as measured by precipitation and inhibition of haemaglutination, were obtained from Bacteroides fragilis NCTC 9343 grown in continuous culture. The activity varied slightly only with the glucose concentration of the medium and the dilution rate. pH had a greater influence on antigen ... | 236,632 | [
-0.03646814,
-0.2913004,
-0.2204949,
0.2669504,
-0.08543864,
-0.2406582,
-0.1128148,
0.1260869,
0.01991346,
-0.01482109,
-0.1036784,
-0.03687559,
-0.1812079,
-0.2327936,
0.06080071,
-0.1945471,
-0.4088187,
-0.03546592,
-0.2341922,
0.17252,
0.4062197,
0.1689252,
0.02586351... |
Ileal HCO3 secretion: relationship to Na and Cl transport and effect of theophylline. | Interrelationships among Na, Cl, and HCO3 transport processes were examined in short-circuited rabbit ileal mucosa. As serosal (HCO3) was increased from 10 to 50 mM (pH from 7.1 to 7.8), net Na absorption decreased from 4.6 to 0.3 mueq/h-cm2, net Cl flux changed from absorption of 0.9 to secretion of 0.9 and a net HCO3... | 236,661 | [
0.07573297,
-0.1698741,
-0.05116622,
-0.106628,
0.03511066,
-0.2819606,
-0.2479504,
-0.05744277,
-0.1981128,
-0.09758416,
0.04464421,
0.2212919,
-0.05203294,
0.07635997,
-0.2249624,
-0.2649533,
-0.4646608,
-0.02621854,
-0.06909756,
-0.04088075,
0.3231488,
0.03468943,
0.11... |
Fluroxene and isolated heart muscle. | The direct myocardial effects of fluroxene were examined in isometrically and isotonically contracting isolated rat heart muscle. MAC, the minimum anesthetic concentration needed to prevent movement in response to tail clamping, was found to be 5.0 vol per cent fluroxene in the rat. At 4.6 vol per cent fluroxene, peak ... | 236,706 | [
-0.08406609,
-0.03789835,
-0.3054993,
-0.4929318,
0.2676174,
-0.1873963,
-0.2770514,
0.3843832,
-0.1598807,
-0.3372835,
0.2519841,
-0.04234094,
0.4386413,
-0.222689,
-0.07951611,
-0.03062036,
-0.4244746,
0.2483438,
0.05919886,
0.5702273,
0.2886457,
-0.07113227,
-0.2901162... |
Nicotinamide-adenine dinucleotide inhibition of pig kidney alkaline phosphatase. | 1. The interaction of NAD+, NADH and various nucleotide analogues with pig kidney alkaline phosphatase (orthophosphoric-monoester phosphohydrolase (alkaline optimum) EC 3.1.3.1) has been investigated by kinetic means. Some inhibitors act uncompetitively whereas others markedly increase the slopes of double reciprocal p... | 236,767 | [
-0.2309413,
0.1305318,
-0.1445114,
0.2327636,
0.04907534,
-0.4061823,
-0.07368826,
0.003032498,
0.007834164,
-0.1312515,
0.105014,
0.1165928,
0.06182171,
0.2672807,
-0.8620251,
-0.01270779,
-0.5642787,
0.1464106,
-0.3636476,
0.1421462,
0.3463322,
0.189797,
-0.4131383,
0... |
Ultrastructural study of crystalloids in sertoli cells of the normal, intersex and experimental cryptorchid swine. | Spindle- or needle-shaped crystalloids are observed in Sertoli cells of the intersex and experimental cryptorchid swine in the light and electron microscopes. Small crystalloids are also observed in Sertoli cells of the normal swine only by electron microscopy. These crystalloids consist of fine filaments. The filament... | 236,833 | [
-0.07105246,
0.2311448,
0.2175293,
0.06633367,
-0.1235217,
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-0.3638563,
0.2669818,
-0.03558879,
0.1183826,
0.2984291,
-0.1555629,
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-0.5074307,
-0.2015956,
-0.3622226,
-0.05178346,
-0.1028709,
-0.04883192,
0.4248887,
0.248538,
-0.1666701,
... |
Vascular responses to prostaglandin F 2 alpha in isolated cat lungs. | Changes in perfusion pressure in response to graded doses of prostaglandin F 2 alpha (PGF 2 alpha) were measured during both forward and retrograde perfusion of isolated cat lungs perfused at a constant flow rate. During forward perfusion, PGF 2 alpha produced a dose-dependent increase in pulmonary artery pressure and ... | 236,839 | [
-0.2648297,
-0.3201438,
-0.1915797,
-0.01247196,
0.052395,
-0.1850216,
0.02705891,
-0.06310868,
-0.2625627,
-0.2563126,
0.07247083,
-0.1073344,
0.02658146,
0.008717286,
-0.4307902,
-0.1758863,
-0.05845024,
-0.03600941,
0.5028797,
0.156422,
-0.001902307,
-0.04608513,
-0.15... |
Colorimetric enzymatic determination of serum total carbon dioxide, as applied to the Vickers Multichannel 300 discrete analyzer. | Phosphoenolpyruvate carbosylase (EC 4.1.1.31) has been used in developing a simple, inexpensive colorimetric assay for serum total carbon dioxide in an open system. The oxaloacetate formed by the action of the enzyme on bicarbonate and phosphoenolpyruvate is measured by use of the diazonium salt of Fast Violet B. Inter... | 236,847 | [
-0.00508037,
0.2777061,
-0.2916803,
-0.1754395,
-0.08603728,
-0.1400584,
-0.2687511,
0.1142702,
-0.1159699,
-0.3592211,
0.2164008,
0.3222073,
-0.01295705,
0.3072677,
-0.2506111,
-0.03417552,
-0.5119818,
0.3871801,
0.1421189,
0.2288401,
0.2510598,
-0.05197429,
-0.192713,
... |
The oxidation of arsenite in seawater. | The oxidation rate of arsenite in seawater is very slow. Of the parameters investigated which might affect this rate the most important were temperature, initial arsenite concentration, salinity and pH. An empirical rate expression was developed from experimental data which led to a prediction that the natural rate of ... | 236,901 | [
-0.07727171,
-0.08022302,
-0.1738217,
0.1082107,
-0.09030471,
0.07075275,
-0.1417007,
0.2844197,
0.02490445,
-0.1529726,
0.09783574,
0.1088618,
0.1724981,
-0.08681904,
-0.002329257,
-0.1628602,
-0.3861913,
0.2439196,
0.07287064,
0.3707528,
0.4920753,
0.1509054,
-0.1851272... |
Separation of two L-glutamine-hydroxylamine glutamyltransferases from rat liver. | The purification of glutamine synthetase (GS) from rat liver demonstrates that a small portion of glutamine-hydroxylamine-glutamyltransferase activity (GT) remains associated with GS activity (GT(S)). As GS is purified from the water extract, the ratio between GT(S) activity (GT(T)) is left to be extracted by KC1 from ... | 236,905 | [
0.002811135,
0.1161874,
-0.4941792,
-0.1238948,
-0.1151893,
-0.2605477,
0.2410892,
-0.02750869,
-0.1227081,
0.1464206,
0.1341099,
0.2458021,
0.1550533,
0.1416692,
-0.3547378,
0.02518719,
-0.4455726,
0.1548779,
0.305476,
0.17234,
0.0277671,
0.1806125,
-0.05086682,
0.0284... |
Effect of free and conjugated bile salts on alpha-amylase activity. | The effect of individual bile salts on alpha-amylase hydrolysis of Cibachron Blue starch was studied at pH 6.0. With sodium cholate, taurocholate and taurodeoxycholate, enzyme activity was increased to 150-160 percent of the control value, at a concentration of similar to 1 mmol/l bile salt. The increased activity exte... | 236,906 | [
-0.001562246,
0.3086441,
-0.2413039,
0.143011,
0.07259309,
-0.0848152,
-0.2309639,
-0.1394361,
-0.07295248,
0.2735318,
0.1523011,
0.06710851,
0.212572,
-0.09236592,
-0.4153833,
0.1143924,
-0.3466628,
0.2554793,
0.1138398,
0.4003358,
0.6146975,
-0.1123499,
0.2490772,
0.1... |
Studies of glucose metabolism in Bacillus subtilis. I. Purification of glucose-6-phosphate dehydrogenase from the vegetative cell and its properties in comparison with the spore enzyme. | 1. Glucose-6-phosphate dehydrogenase [D-glucose-6-phosphate : NADP-+ 1-oxidoreductase, EC 1.1.1.49] from vegetative cells of Bacillus subtilis was purified about 2,400-fold. The purified enzyme was shown to be homogeneous as judged by chromatographic profile, polyacrylamide gel electrophoresis and ultracentrifugation. ... | 236,997 | [
-0.1562332,
-0.155646,
-0.2512033,
-0.03040664,
-0.0313637,
-0.3883168,
-0.1483415,
0.08752423,
-0.1603787,
-0.236763,
0.1807484,
0.0292525,
-0.3076709,
0.2082149,
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0.1823451,
-0.2905531,
0.344135,
0.3502076,
0.07635643,
0.5917375,
0.3088802,
0.004364233,
0.1... |
Affinity chromatography of beta-galactosidase on controlled-pore glass derivatives. | Several controlled-pore glass (CPG) derivatives were examined as supports for the affinity chromatographic purification of the enzyme beta-galactosidase. The competitive inhibitor p-aminophenyl-beta-D-thiogalactopyranoside was coupled to an azelaic acid and a malonic acid derivative of 750-A alkylamine CPG of 80-120 me... | 237,008 | [
-0.07287496,
0.1429969,
-0.09315024,
0.07674327,
-0.06992777,
0.3200994,
-0.1790204,
-0.2791295,
0.1951353,
0.02046875,
-0.1639812,
-0.07198469,
0.2163113,
0.02986438,
-0.8762668,
0.3542149,
-0.5563248,
0.2256046,
-0.03318416,
0.07126252,
0.6399813,
0.1424333,
-0.2147207,... |
Vasoconstriction of the isolated rabbit ear artery caused by nicotinic agonists acting on adrenergic neurons. | In the perfused isolated central ear artery of the rabbit, nicotine, acetylcholine (ACh), tetramethylammonium (TMA) and carbachol (CCh) at high concentrations (greater than 1 mug/ml) produced transient vasoconstriction. The order of potency was: nicotine greater than ACh greater than TMA greater than CCh. Over the conc... | 237,110 | [
0.09380922,
-0.169056,
-0.663078,
-0.3990904,
0.008390523,
-0.3187692,
-0.1991622,
0.1983066,
-0.06056371,
0.1748649,
0.2005247,
0.3160124,
-0.007404791,
-0.06875826,
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-0.6521751,
0.3559135,
0.07696436,
0.02963805,
0.2343295,
0.0552834,
0.3046999,
... |
Effects of beta adrenergic blocking agents on erythropoietin production in rabbits exposed to hypoxia. | The effects of dl-propranolol, d-propranolol, butoxamine or practolol on erythropoietin (ESF) production in rabbits exposed to hypoxia (0.42 atmosphere) for 18 hours were investigated. Rabbits treated with dl-propranolol (4 or 8 mg/kg i.p.) or butoxamine (15 or 30 mg/kg i.p.) produced significantly less ESF in response... | 237,111 | [
0.1512913,
-0.002669955,
-0.370213,
0.1507754,
0.01964486,
-0.2165705,
-0.08121353,
-0.3019827,
-0.1546019,
-0.2108465,
-0.281496,
0.4198115,
-0.04253392,
0.1210332,
-0.03601937,
-0.3818803,
-0.3516801,
0.30035,
0.203269,
0.2340941,
-0.2446319,
0.4109841,
-0.03373443,
-... |
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