title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Immunocytochemical demonstration of calcitonin-containing C-cells in the thyroid glands of different mammals. | In the thyroid glands of the horse, pig, deer, mole, and rat, C-cells could be demonstrated by means of the immunocytochemical PAP-technique using rabbit antisera against human calcitonin. Only in ruminants, the cross-reaction between the intracellularly stored antigen and the antibodies used appeared to be incomplete. | 342,107 | [
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Treatment of senile osteoporosis with 1alpha-hydroxyvitamin D3. | About 30% of patients with clinical osteoporosis had histological signs of osteomalacia, in spite of normal serum 25-hydroxyvitamin D3 (25-OHD3). The excess osteoid disappeared during treatment with 1alpha-hydroxyvitamin D3 (1alpha-OHD3). These patients might have reduced ability to convert 25-OHD3 to 1,25-dihydroxyvit... | 342,143 | [
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Studies on the heterophile antibodies of infectious mononucleosis. I. Separation of four antibody populations, one of which contains lymphocytotoxic activity. | With the aid of insolubilized immunoadsorbents made with glycoproteins, extracted from cow red blood cells (RBC), and with guinea-pig kidney tissue, heterophile antibody populations of the Paul--Bunnell type and the Forssman type were eluted from infectious mononucleosis sera. Two Paul--Bunnell-type antibody population... | 342,158 | [
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[In-patient treatment of peptic ulcer with cimetidine. I. Effect on duodenal ulcer healing (author's transl)]. | The effect of 300 mg cimetidine q.i.d. on ulcer healing was studied in a controlled double-blind clinical trial of 71 in-patients with duodenal ulcer. Healing occurred in 48.5% of patients in the cimetidine group after two weeks, and in 20.6% in the placebo group (P less than 0.05). The healing rate was 88% in the cime... | 342,217 | [
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[In-patient treatment of peptic ulcer with cimetidine. II. Controlled double-blind trial on gastric ulcer patients (author's transl)]. | In a controlled double-blind clinical trial of 39 in-patients with gastric ulcer the effect of cimetidine on ulcer healing, ulcer pain and pentagastrin-stimulated acid and pepsin secretion was measured. A faster healing rate in the cimetidine group was statistically not significant. Cimetidine had no effect on ulcer pa... | 342,218 | [
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Cimetidine: a review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease. | Cimetidine is a specific competitive histamine H2-receptor antagonist which effectively inhibits gastric acid secretion and is advocated for the treatment of chronic peptic ulceration, haemorrhage from erosive gastritis, and the control of gastric hypersecretion and peptic ulceration in the Zollinger-Ellison syndrome. ... | 342,231 | [
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Double-blind oral analgesic study of butorphanol in musculoskeletal pain: a comparison with codeine and placebo. | Butorphanol tartrate (4 mg and 8 mg) was compared to codeine phosphate (60 mg) and placebo for oral analgesic activity and side-effects employing a double-blind design in ninety-three out-patients suffering from moderate to very severe musculoskeletal pain. The study duration was 72 hours with medication administered e... | 342,300 | [
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Clinical trial of acebutolol (Sectral) in hypertension. | Acebutolol (Sectral) was used successfully in a clinical trial involving thirty-two hypertensive patients. Twenty-three patients received acebutolol at a dosage of 400--800 mg daily as sole treatment and nine patients received concurrent treatment with thiazide diuretics. In both groups of patients there was a substant... | 342,303 | [
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An attenuated influenza virus vaccine: protection against homologous and heterologous strains of virus. | An effective influenza vaccine should be capable of providing protection against both the homologous virus strain and heterologous strains representing antigenic "drift". Two attenuated vaccines were evaluated, an A/Hong Kong/8/68 (H3N2) and an A/England/42/72 (H3N2) strain. Volunteers were immunized intranasally with ... | 342,305 | [
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Clinical reactions to an adsorbed killed trivalent influenza vaccine (including A/New Jersey 8/76 antigen) with different immunization methods. | The local and general reactions of 489 individuals vaccinated with an adsorbed killed influenza vaccine (containing A/New Jersey 8/76, A/Victoria 3/75, B/Hong kong 8/73 antigens) were studied on the fourth day after vaccination. 179 participants were vaccinated by syringe, the rest by jet injector. Local indurations we... | 342,310 | [
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Clinical trials with a new influenza subunit vaccine in adults and children. | The reactogenicity and immunogenicity of a new influenza subunit vaccine containing essentially only hemagglutinin and neuraminidase has been studied in man. Studies in primed individuals demonstrated that the subunit vaccine induced antibody levels as high as those induced by a comparable whole virus vaccine, or a com... | 342,311 | [
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Possible toxic effects of normal and diabetic patient serum on pancreatic B-cells. | Serum from normal blood-donors and juvenile diabetic patients inhibited Rb+ accumulation and stimulated release of 51Cr and insulin in suspensions of dispersed pancreatic islet cells prepared from ob/ob mouse islets, which are rich in B-cells. The effects indicate the presence of a B-cytotoxic factor in human serum. Se... | 342,324 | [
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Chronic laxative abuse associated with pancreatic islet cell hyperplasia. | Marked pancreatic islet cell hyperplasia was found in a patient with laxative-induced diarrhoea. It is suggested that laxative abuse might be an important aetiological factor in patients with pancreatic islet cell hyperplasia and the watery diarrhoea syndrome but in whom no hormonal excess can be demonstrated. | 342,355 | [
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Effect of L1210 leukemia on the susceptibility of mice to Candida albicans infections. | This study was carried out to determine whether animals bearing L1210 leukemia were more susceptible to candida infection in the absence of immunosuppression and to determine also if the L1210 cells suppressed the inflammatory response of the animal host. Systemic infection was studied by intravenous injection of Candi... | 342,409 | [
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Effect on particle size of solubilization of wild-type and Re chemotype lipopolysaccharides solubilized with bovine serum albumin and triethylamine. | Disaggregation of wild-type and Re chemotype lipopolysaccharides (LPS) has been accomplished by solubilization with triethylamine followed by stabilization with bovine serum albumin in order to determine the degree of aggregation. Solubilization with 1.5% triethylamine was found to be more effective than with lower con... | 342,411 | [
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Mitogenic activity of bacterial lipopolysaccharides in vivo: morphological and functinal characterization of responding cells. | The in vivo effect of bacterial lipopolysaccharides (LPS) on mouse spleen cell subpopulations was investigated. Intravenous administration of LPS resulted in marked enlargement of the spleen, accompanied by increased cellular proliferation and enhanced nucleated cell recoveries. At least two morphologically distinct ce... | 342,416 | [
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Complexity of branching dendritic trees: dependence on number of trees per cell and effects of branch loss during sectioning. | We have investigated whether the complexity of dendritic trees is correlated with the number of primary dendrites per neuron (trees per cell). In estimating the average number of branches of centrifugal orders 1-5 per tree we used statistical methods to compensate for loss of parts of trees during sectioning. Limitatio... | 342,471 | [
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Carriomycin, a new polyether antibiotic produced by Streptomyces hygroscopicus. | Carriomycin, a new polyether antibiotic, was isolated from culture broth of Streptomyces hygroscopicus strain T-42082. It is active against Gram-positive bacteria, several fungi, yeasts and mycoplasma. It is also coccidiostatic. The free acid of carriomycin occurs as colorless prisms having the molecular formula C47H80... | 342,475 | [
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Requirements for suppression of a dnaG mutation by an I-type plasmid. | We have confirmed and further characterized the phenomenon of suppression of a dnaG mutation by an I plasmid and determined the requirements for the complete expression of suppressibility. The authentic derepressed mutation of the conjugal fertility system, described earlier, was shown to be one of the requirements. Th... | 342,493 | [
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Escherichia coli mutants with defects in the biosynthesis of 5-methylaminomethyl-2-thio-uridine or 1-methylguanosine in their tRNA. | Two tRNA methyltransferase mutants, isolated as described in the accompanying paper (G.R. Björk and K. Kjellin-Stråby, J. Bacteriol. 133:499-207, 1978), are biochemicaaly and genetically characterized. tRNA from mutant IB13 lacks 5-methylaminomethyl-2-thio-uridine in vivo due to a permanently nonfunctional methyltransf... | 342,495 | [
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Genetic analysis of antibiotic resistance in Streptococcus pyogenes. | The genetics of antibiotic resistance in mutant strains of Streptococcus pyrogenes was studied. Utilizing a type 6 strain (9440) primarily resistant to strepttomycin (Strr), classes of mutant strains were isolated that were resistant to one of the following antibiotics: rifampin (Rifr), erythromycin (Eryr), thiostrepto... | 342,510 | [
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Expression of the uvrB gene of Escherichia coli: in vitro construction of a pMB9 uvrB plasmid. | Bacteriophage lambdab2att2 [lambdab2cI857intam6(deltabioAB)bioFCD+uvrB+phr+] codes for a function(s) that confers UV resistance (Uvr+) and reactivation of irradiated phage (Hcr+) to an Uvr-Hcr-Escherichia coli strain. It was demonstrated that these functions are expressed under the control of bacterial regulatory eleme... | 342,513 | [
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The clinical use of combined xenografts of bone and autologous red marrow. A preliminary report. | The beneficial effect upon osteogenesis of imprenating bone grafts with autologous red marrow is well documented. The experimental findings reported in a previous paper suggested that prepared xenograft bone might provide a good medium for osteogenesis by marrow cells. This paper is a preliminary report of the first cl... | 342,531 | [
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Use of cell cultures as an indicator of pathogenicity of free-living amoebae. | Results comparing the time needed for the development of cytopathic effects in cell cultures with that needed to cause death in mice using inocula of Naegleria and Acanthamoeba are presented. The significance of the source and concentration of the inocula is demonstrated. The use of cell cultures as an indicator of the... | 342,543 | [
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Infection with Bacillus Calmette-Guérin activates murine thymus-independent (B) lymphocytes. | Thymus-independent (B) lymphocytes from BCG-infected mice respond with enhanced or depressed levels of proliferation relative to the nonspecific levels of stimulation induced by tuberculin. The type of response obtained depends on how BCG was administered and the source of the lymphocytes. The proliferation of splenic ... | 342,604 | [
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Quantitative determination of human leukocyte interferon by microfluorometric immunoassay with FITC-labeled anti-interferon immunoglobulin. | The possibility of quantitative determination of human leukocyte interferon using FITC-labeled anti-interferon antibody was studied. Anti-interferon immunoglobulin of high specific activity was obtained as a result of long-term immunization of a donkey with human leukocyte interferon preparation and subsequent fraction... | 342,608 | [
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Rapid method for preparing bone marrow cells from small laboratory animals. | A new method is described by which long bones may be removed from small laboratory animals for the preparation of bone marrow cell suspensions for use in immunologic assays. Bones are obtained free of muscle and cartilage, and the procedures is adaptable for use under aseptic experimental conditions. | 342,612 | [
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Immunogenicity and reactogenicity of influenza A/New Jersey/76 virus vaccines in normal adults. | Inactivated influenza A/New Jersey/76 virus vaccines were administered intramuscularly to 199 normal adults, aged 19-59, in doses of 200, 400, or 800 chick cell-agglutinating units in a double-blind, placebo-controlled trial. Systemic reactions (including fever) were uncommon, were mild, lasted less than 24 hr, and wer... | 342,618 | [
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... |
Reactogenicity and immunogenicity of parenteral monovalent influenza A/Victoria/3/75 (H3N2) virus vaccine in healthy adults. | Monovalent influenza A/Victoria/3/75 whole-virus vaccines prepared by Merck Sharp and Dohme (West Point, Pa.) and Merrell-National Laboratories (Cincinnati, Ohio) and split-virus vaccines prepared by Parke, Davis and Company (Detroit, Mich.) and Wyeth Laboratories (Philadelphia, Pa.) containing 200, 400, and 800 chick ... | 342,622 | [
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... |
Studies of inactivated influenza virus vaccines in hospital employees: reactogenicity and absenteeism. | The impact of a mass influenza vaccination program on the operation of a major medical center was evaluated in adult volunteer employees who were given either ether-split or whole-virus bivalent influenza vaccine in a double-blind manner by jet-injector gun. Each volunteer completed a reaction information form, nurses ... | 342,626 | [
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... |
The interaction in vitro of Pneumocystis carinii with macrophages and L-cells. | A model was developed for studying the interaction between Pneumocystis, rat-derived cells, and humoral factors. Pneumocystis were obtained in large quantity by bronchial lavage of steroid-treated rats. The trophozoite was the predominant form obtained, and it could readily be recognized by phase contrast microscopy. O... | 342,665 | [
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0.1897098,
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Piroxicam (CP 16171) in rheumatoid arthritis: a controlled clinical trial with novel assessment techniques. | Piroxicam (CP 16171), a new nonsteroidal anti-inflammatory agent, decreased pain, stiffness, and inflammation and increased the patient's ability to perform tasks in a double-blind study of patients with active, definite rheumatoid arthritis, poorly controlled despite standard therapy. Clinically and statistically sign... | 342,691 | [
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Calcium antagonists and islet function: VII. Effect of calcium deprivation. | The role of extracellular Ca2+ in the regulation of islet function is investigated. Decreasing extracellular Ca2+ concentrations cause a dose-related inhibition of glucose-induced insulin release. Whereas the efflux of 45Ca from perifused islets is transiently increased on exposure to Ca2+-deprived media, it is unaffec... | 342,698 | [
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... |
The chemotherapy of leprosy from a microbiological standpoint. | The increased knowledge concerning microbiology and chemotherapy of leprosy is exposed. Great stress is put on the knowledge of chemotherapy of tuberculosis that has accumulated during the last two decades and the guidelines that are equally valid for the chemotherapy of leprosy. The problems of the chemotherapy of the... | 342,826 | [
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0.1092867,
0.045674... |
An endotoxin induced serum factor that causes enhancement of antibody response to heterologous erythrocytes. | The sera obtained from blood of the mice, which had been intravenously injected with LPS several hours in advance, contained some active substance capable of enhancing anti-sheep red blood cell (SRBC) antibody responses in mice. Activity of the sera was still retained after passage through a rabbit anti-LPS antibody-co... | 342,876 | [
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[Effects of the beta-adrenergic blocking agent propranolol on the carbohydrate- and lipometabolism (author's transl)]. | Intravenous glucose tolerance tests were performed in 17 patients suffering from hyperthyreosis before and after a week of treatment with propranolol. The blood taken until the 125. minute after the glucose load was used for the determination of serum glucose, the free fatty acids (FFA), the free glycerol and the radio... | 342,883 | [
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... |
Caffeine enhancement of radiation killing in different strains of Saccharomyces cerevisiae. | Haploid and diploid wild type strains, and three classes of radiation-sensitive mutants of Saccharomyces cerevisiae were tested for enhancement of UV-inactivation by caffeine in growth medium. In addition, the sensitizing effect of caffeine was studied in a haploid and a diploid wild type strain after gamma-irradiation... | 342,906 | [
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A gene involved in the metabolic control of ppGpp synthesis. | A genetic locus has been identified which controls the basal synthesis of ppGpp in growing E. coli. Cells carrying a recessive allele of the relX gene have a very low concentration of ppGpp during balanced growth, and fail to accumulate ppGpp in response to carbon/energy source downshift. Moreover, the recessive relX a... | 342,913 | [
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0.39495,
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Relationships between mutation and transformation frequencies in mammalian cells treated "in vitro" with chemical carcinogens. | An analytical quantitative comparison of data from the literature about frequencies of mutations and transformations induced by mutagenic-carcinogenic compounds in mammalian cells was carried out without any selection of unfitting data. The analysis was performed for equitoxic doses and background level. Data on transf... | 342,929 | [
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0.3209331,
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High mutagenicity of N-(alpha-acyloxy)alkyl-N-alkylnitrosamines in S. typhimurium: model compounds for metabolically activated N,N-dialkylnitrosamines. | A series of N,N-dialkylnitrosamines (alkyl means methyl, ethyl, n-propyl, n-butyl or tert-butyl group) mono-substituted at the alpha-carbon with an acetoxy group, were tested for their mutagenic action in Salmonella typhimurium TA1530 in the presence or absence of a rat-liver supernatant from 9000 X g. The presumed rel... | 342,933 | [
-0.5925372,
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0.02319812,
... |
Diepoxybutane-induced male-transmissible X-autosome translocations in Drosophila melanogaster: a test of the supporting evidence for the Lifschytz-Lindsley model of spermatogenesis. | The Lifschytz-Lindley model of spermatogenesis in heterogametic animals postulates a stage of gene inactivation during spermatogenesis, which affects the X-chromosome and the autosomes at different times. The frequent male infertility of X-ray induced X-autosome translocations is attributed to disruption in the timing ... | 342,935 | [
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0.... |
Mutagenic effect of dichloromethane on Salmonella typhimurium. | The possible mutagenicity of the organic solvent dichloromethane was investigated with the mutation test as described by Ames et al. The compound was mutagenic in both tester strains used, namely TA98 and TA100. The administration of rat-liver homogenate did not appear to be essential though it slightly increased the n... | 342,942 | [
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Mutagenicities of the pyrolyzates of peptides and proteins. | Pyrolyzates of 10 peptides, 10 proteins and 5 naturally-occurring materials were tested for mutagenicity in the histidine-requiring mutants Salmonella typhimurium TA98 and TA100. Significant mutagenic activity was detected with pyrolyzates of most of these materials. The pyrolyzates requred a liver microsomal fraction,... | 342,945 | [
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... |
Desamino arginine vasopressin (DDAVP) as a diagnostic agent. | The use of 1-desamino-8-arginine vasopressin (DDAVP) was examined as a diagnostic agent, within the context of the comprehensive one day renal function test. Thirty-three normal young subjects were examined in an 8 1/2 hour day. It was found that a 20 microgram intranasal dose of DDAVP consistently resulted in the prod... | 343,010 | [
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Carpal tunnel syndrome in pregnancy. | The signs and symptoms of carpal tunnel syndrome in pregnant patients are outlined and the diagnostic methods are reviewed. Carpal tunnel syndrome that occurs during pregnancy almost invariably abates postpartum. Due to the benign course and excellent prognosis in most cases, splinting of the wrist is indicated in the ... | 343,016 | [
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Effect of noxythiolin on experimental peritonitis. | The intraperitoneal instillation of noxythiolin in the treatment of peritonitis is widespread in clinical practice despite contradictory evidence as to its efficacy. In this light the value of noxythiolin was reappraised by studying its effect in guinea-pigs and mice with induced bacterial peritonitis. Treatment with a... | 343,081 | [
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0.03965904... |
Behavioral and electroencephalographic manifestations of avian epilepsy: a review of the literature. | Recently, electrophysiological studies on sleep and wakefulness in birds have yielded useful results. Furthermore, recent evidence obtained in behavioral and electroencephalographical investigations of epileptic birds, induced neuropharmacologically or genetically, have led to recognition of the fact that epileptic sei... | 343,084 | [
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[Analysis of gamma-ray spectra by using fast Fourier transform (author's transl)]. | In order to simplify the mass data processing in a response matrix method for gamma-ray spectral analysis, a method using a Fast Fourier Transform devised. The validity of the method was confirmed by a computer simulation for spectra of a NaI detector. The method uses the fact that spectral data can be represented by F... | 343,189 | [
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[Comparative study of 3 irreversible hydrocolloids]. | This study was realized: to determine the best manipulation of 3 alginates; to compare their dimensional stability; to compare their reproduction of detail; to evaluate, through these 3 criteria, the best of the 3 alginates. It seems necessary to point out that: The 3 examined alginates show a poor dimensional stabilit... | 343,247 | [
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Myosin: immunofluorescent localization in neuronal and glial cultures. | The distribution of intracellular myosin was studied by the double antibody immunofluorescence method in primary organotypic neuronal cultures and two established neuronal and glial cell lines. An array of parallel filaments aligned with the major cellular axis and a three-dimensional subsurface network were shown to r... | 343,252 | [
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Transplantation of children's kidneys into adult recipients. | In the present study of 31 kidneys transplanted from donors ranging in age from one to one-half to nine years, the ability of kidneys from donors in the pediatric age group to provide adequate renal function in adults is evaluated. Kidney function was reviewed six months, one year, three years and five years after tran... | 343,278 | [
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0... |
Pancreatic autotransplantation following resection. | A patient with recurrent pancreatitis was treated by near-total pancreatectomy. The tail of the pancreas, together with the splenic artery and vein, was transplanted into the thigh, with anastomoses of the splenic vessels to the femoral vessels. Two months after operation simultaneously drawn blood samples from both fe... | 343,288 | [
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Treatment of intestinal amoebiasis and vaginal trichomoniasis with panidazole and its comparison with metronidazole. | A dose range study in 18 patients suffering from intestinal amoebiasis and treated with doses of panidazole between 1.0 and 2.0 g per day for six days revealed that the best therapeutic results were obtained with the higher dose. This dose was then compared with metronidazole, at the same dose, in a clinical trial in 1... | 343,312 | [
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0.... |
A study of the conversion from paid to altruistic blood donors in New Mexico. | We investigated the recent conversion of the New Mexico blood supply from a donor recruitment base which depended almost entirely upon paid, responsibility fee, and insured donors to 100 per cent reliance upon altruistic donors. Blood Services of New Mexico (BSNM) effected this change. The local Red Cross played a key ... | 343,326 | [
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0.04307692,
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Pathological changes in the small intestine of neonatal calves with enteric colibacillosis. | Three neonatal calves, protected from colisepticaemia by intravenously administered immunoglobulin M, were infected orally with Escherichia coli type 0101 K?(A). All calves developed severe enteric colibacillosis. When they were 4 days old stunting and fusion of villi were seen in the distal half of the small intestine... | 343,349 | [
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0.2383565,
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-0.2536832,
-0.1458182,
0.09057755,
0.2937721,
0.1444811,
0.01522927... |
[The roux-en-y-loop (author's transl)]. | 78 patients were operated on from 1st July to 31th December 1976 according to the method of Roux-en-Y-loop under several indications concerning primary and secondary reconstructive procedures in abdominal surgery. The experiences made are good. We recommend this method. | 343,438 | [
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0.08583954,... |
[Echinococci of the spinal canal]. | The authors present a 51-year-old patient who was admitted to the neurosurgical department of the hospital because of paraparesis and vegetative disturbances. Myelography showed a complete lumbosacral stop. During surgery, large masses of Echinococcal cysts were removed from the extradural space. 20 months after the in... | 343,442 | [
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0.1591642,
0.133543,
... |
[Bacteriocinogenic properties of Proteus]. | As revealed, bacteriocinogenia was widespread in bacteria of the Proteus genus (85 +/- 3.87%). Proteus cultures isolated from various sources failed to differ by the number of bacteriocinogenic cultures and by bacteriocinogenic activity. Bacteriocinogenic cultures were mostly revealed among the Proteius mirabilis strai... | 343,455 | [
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0.1030686,
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[Submicroscopic study of bacteria and spores under the effect of peracetic acid and various aspects of the mechanism of its action]. | Microbial cells (E. coli and staphylococcus) and B. cereus spores were used in this work. Peracetic acid in a concentration of 0.005% caused the death of 99% of the microbes in 20 minutes, and 0.1% peracetic acid caused the death of 99% of the spores in 45 minutes. Changes in the surface and internal structures of the ... | 343,456 | [
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0.5053762,
0.4044137,
0.09778129,
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Osteogenesis after bone and bone marrow transplantation. II. The initial cellular events following transplantation of decalcified allografts of cancellous bone. | An experimental study was done in rabbits to investigate the fate of allogeneic iliac cancellous bone, both non-decalcified and decalcified with hydrochloric acid, transplanted to a muscular site for up to 14 days. Some of the treated allografts were impregnated with autologous bone marrow cells, obtained from the femo... | 343,478 | [
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0.1047486,
0.1653495,
0.1269648,
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On the diagnosis of coagulase-negative staphylococci with emphasis on Staphylococcus saprophyticus. | This study concerns the diagnosis of coagulase-negative staphylococci, with special emphasis on novobiocin-resistant species, vis S. saprophyticus, S. cohnii and S. xylosus. Disc diffusion tests for novobiocin were found useful in the differential diagnosis of coagulase-negative staphylococci isolated from urine specim... | 343,493 | [
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0.02269556,
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0.2037238,... |
Humoral and cell-mediated immunity to hepatitis B virus antigen in a haemodialysis-renal transplantation unit. | Hepatitis B surface antigen (HBsAg), the corresponding antibody (anti-HBs), the antibody to hepatitis B core antigen (anti-HBc), and the cellular immune response to purified HBsAg (leucocyte migration inhibition test: LMT-HBsAg) were determined in 19 staff members, 11 long-term haemodialysis patients, and 22 renal tran... | 343,497 | [
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0.1630095,
0.1313099,
0.3220304,
0.06521368,
... |
Visual field defects, cup-disc ratio and fluorescein angiography in glaucomatous optic atrophy. | Fluorescein angiography was carried out in 150 glaucoma subjects. Among them 94 subjects were selected to evaluate the correlation between functional loss and the findings of fluorescein angiography in the optic disc. The intensity of fluorescence was assessed in the superficial reticular capillaries and radial epipapi... | 343,552 | [
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0.2371374,
0.2401068,
... |
Comparison of a commercial identification kit and conventional biochemical tests used for the identification of enteric gram-negative rods. | A comparison between 11 Minitek biochemical tests and corresponding conventional tubed media was undertaken with 1,089 isolates of enteric gram-negative rods. Overall correlation between Minitek and conventional biochemicals was 97.4%. Minitek proved to be a time- and space-saving miniaturized biochemical system that c... | 343,571 | [
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0.3458933,
0.2614004,
0.2973848,
0.1... |
Yersinia enterocolitica septicemia. | Yersinia enterocolitica was recovered from the blood of an infant with sepsis and fever but with few gastrointestinal symptoms. The age of this patient was unusual as septicemia owing to this organism has most frequently been seen in adults. Because of the absence of digestive symptoms, it is uncertain what the portal ... | 343,573 | [
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0.1671611,
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Gastric analysis in selected populations. Improvement of its clinical usefulness. | Little doubt exists concerning the limited usefulness of gastric analysis as a screening test in unselected populations. Reliable tests, such as those for glycemia, are also of limited value when performed blindly on the general population. When, however, gastric analysis is performed on an adequate preselected populat... | 343,581 | [
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Chromosomal aneuploidy in a patient with hypereosinophilic syndrome. Evidence for a malignant disease. | A patient with rapidly fatal hypereosinophilic syndrome and a bone marrow chromosomal abnormality, 49,XYY,t(3:5),+8,+mar, is described. Scanning and transmission electron microscopy of eosinophils failed to reveal any significant abnormalities. Previous cytogenetic data on patients with hypereosinophilic syndrome have ... | 343,585 | [
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0.1008674,
0.356521,
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Clinical relevance of research on the structure of human chorionic gonadotropin. | Human chorionic gonadotropin (hCG) has been studied extensively over the past 10 years, and some structural correlates of its chemical, biological, and immunologic properties have been defined. A review of these observations and their relevance to clinical applications of methods for detecting hCG is presented. | 343,593 | [
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Chest physiotherapy: the effect on arterial oxygenation. | A prospective study of 47 patients during mechanical ventilation with positive end-expiratory pressure was undertaken to evaluate changes in Pao2 following chest physiotherapy. In contrast to other studies, we found no significant change in Pao2 following chest physiotherapy (p greater than 0.05). Different technics fo... | 343,646 | [
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Pathophysiology of capillary circulation: Raynaud's disease. | Despite the frequency of Raynaud's disease in cold climates, the etiology of the condition remains uncertain. This report reviews the literature since Raynaud's original description and Lewis and Pickering's addition to the concept, and several recent observations which add to our understanding of the disease are discu... | 343,651 | [
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0.2847289,
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Asymptomatic coronary artery disease: angiography in diabetic patients before renal transplantation. Relation of findings to postoperative survival. | Twenty-one juvenile-onset diabetic patients with azotemic nephropathy underwent coronary angiography and left ventriculography before renal transplantation or chronic hemodialysis. Two-year survival of 12 patients with no coronary artery disease (group A) was 88% compared to 22% for nine patients with coronary artery d... | 343,680 | [
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0.2585168,
0.4109887,
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... |
Cicatricial pemphigoid and rheumatoid arthritis. | A review of our experience with cicatricial pemphigoid revealed three patients with cicatrical pemphigoid and rheumatoid arthritis and one patient with ankylosing spondylitis who had a high titer of rheumatoid factor. A comparison of these four patients with patients who had bullous pemphigoid and rheumatoid arthritis ... | 343,718 | [
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0.2498834,
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0.2168936,
-0.007240279,
0.068... |
Naproxen in osteoarthrosis. Double-blind crossover trial. | In this double-blind crossover trial, naproxen (750 mg/day) was compared to placebo for the treatment of osteoarthrosis of the hip and knee. Patients were randomly assigned to treatment with either naproxen or placebo for 4 weeks and then to treatment with the alternate agent for a second 4-week period. 8 out of 9 obje... | 343,726 | [
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0.2309367,
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0.1697244,
0.1683744,
0.1262231,
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Hematuria in renal transplant recipients. | This study is a retrospective analysis of microscopic and gross hematuria in 127 male renal transplant recipients. The incidence of hematuria was 12%. The causes of hematuria were similar to those in the general population with inflammatory conditions predominating. Urologic malignancy was not found. Hematuria heralded... | 343,737 | [
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Moderate and extreme hemodilution in open-heart surgery: fluid balance and acid-base studies. | Two groups of patients underwent aortic valve replacement. Fifteen patients received moderate hemodilution (mean hematocrit, 27%) with 40% donor blood in the priming solution. Extreme hemodilution was used in 14 patients (mean hematocrit, 18%) with a nonhemic prime and withdrawal of blood at the start of operation. Bot... | 343,739 | [
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0.1016268,
0.3510919,
0.1153355,
0.1116571,
-... |
Long-term blood pressure changes in renal homotransplantation. | Long-term blood pressure changes were studied in 50 patients who had undergone renal homotransplantation. Excluded were those subjects with arterial stenosis of the transplanted kidney, acute or rapidly progressive rejection, or recurrent glomerulonephritis, as well as those retaining their own diseased kidney(s). The ... | 343,741 | [
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[Morphology of the endocrine portion of the teleost pancreas]. | Endocrine component of the crucian (Carassius carassius), carp (Cyprinus carpio), tench (Tinca tinca) and silurus (Silurus glanis) pancreas is structurally organized in the form of pancreatic islets. Gorbusha (Oncorhynchus gorbuscha) has, besides the islets, some Brockman's bodies. Endocrine component of the pancreas o... | 343,755 | [
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0.3925118,
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-0... |
Photobinding of 8-methoxypsoralen to transfer RNA and 5-fluorouracil-enriched transfer RNA. | The photobinding of [3H]8MOP to tRNA upon irradiation at 365 nm in the absence of O2 was determined by gel filtration. The maximum photobinding was found to be ca. 4 mol of 8MOP er mol of tRNA and 5FU-tRNA, with an overall quantum yield of 2.3 X 10(-3). The photobinding kinetics for 8MOP-tRNA showed an apparent inducti... | 343,811 | [
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0.4345733,
0.1024359,
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-0.1... |
Metabolic effects of heavy physical training on female 'age-group' swimmers. | Twelve female age-group swimmers and twelve female controls, aged ten to sixteen, performed a pre-training discontinuous maximal cycle ergometer test to determine the capacities of their anaerobic (alactacid and lactacid) and aerobic energy systems. Heart rate and oxygen uptake were determined during rest, exercise, an... | 343,860 | [
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0.1295005,
0.2339902,
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-... |
Cigarette smoking and reactions to air pollutants. | There are many mechanisms whereby recent exposure to cigarette smoke augments the toxicity of common air contaminants: the total pollutant burden is increased, there is cumulative irritation of the airways, pollutants are deposited selectively in the airways, ventilatory patterns are altered, mucus production is increa... | 343,900 | [
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0.08177943,
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0.3365992,
0.03511781,
... |
Postdiarrheal arthropathy of Yersinia pseudotuberculosis. | Two patients with acute gastroenteritis in whom polyarthritis subsequently developed were found to have positive serologic results for Yersinia pseudotuberculosis. With resolution of the arthropathy the antibody titres decreased. While the patient without the histocompatibility antigen HLA-B27 had an acute, self-limite... | 343,903 | [
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0.1292663,
0.03187573,
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... |
Role of the adrenal cortex and sodium in the pathogenesis of human hypertension. | After 30 years of continuous research into the mechanisms of human hypertension, we summarize the results obtained by the members of the multidisciplinary research group on hypertension of the Clinical Research Institute of Montreal on the disturbances of minerlocorticoid activity in a rigorously selected group of pati... | 343,905 | [
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0.4024115,
0.08941077,
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Anaerobic liver abscess and intrahepatic metastases: a case report and review of the literature. | A patient is described in whom the first recurrence of a cloacogenic carcinoma of the rectum was an intrahepatic metastasis associated with an hepatic abscess caused by the anaerobic bacterium Peptococcus prevotii. Three previously reported cases of infection associated with hepatic tumor nodules have been found in whi... | 343,910 | [
-0.2826841,
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0.2134392,
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-0.2357907,
-0.4796111,
-0.04378295,
-0.150831,
-0.1621633,
0.1502579,
0.3449847,
-0.03232949,
-0.08856194,
-0.549769,
-0.3020776,
-0.3704957,
0.1377189,
0.278626,
0.02296337,
0.08600753,
0.1650823,
-0.09291044,
... |
Granulocytic sarcoma of the uterus. | The presenting features of vaginal bleeding and abnormal cytologic smears in a elderly patient with simultaneously occurring acute myelogenous leukemia (AML), were due to massive infiltration of the uterine cervix and endometrium by immature myeloid elements or granulocytic sarcoma. The abnormal cytologic smears and ut... | 343,911 | [
-0.1531178,
0.4771461,
-0.4123282,
-0.2033111,
0.1712757,
-0.214436,
-0.3214652,
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0.02214464,
0.2419412,
0.0008862048,
0.4076579,
0.1499136,
0.2852993,
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-0.2298266,
0.002198136,
-0.2700675,
0.09465524,
0.6408207,
0.07601723,
-0.2092949,... |
Different myosins in myoid and entodermal reticular epithelial cells of the thymus. An immunocytochemical study using specific antibodies against striated and smooth muscle myosin. | A sensitive immunofluorescence microscopical technique employing specific antibodies against highly purified actin and (smooth muscle type) myosin from chicken gizzard and myosin from human striated muscle was used to localize these contractile proteins in the thymus of rat, guinea-pig, cat and chicken. Myoid cells wer... | 343,919 | [
0.116356,
-0.2044523,
-0.2883765,
-0.1405078,
-0.006712304,
-0.1165137,
-0.3512443,
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0.009375028,
0.285402,
0.1666691,
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0.0869606,
0.2721067,
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-0.1181085,
-0.3538541,
0.00685497,
0.2129409,
0.1042671,
-0.08553983,
... |
The development of Chinese herbal medicine and the Pen-ts'ao. | Chinese medicine employs complex mixtures of remedies and does not appreciate the advantage or effectiveness of a single drug entity. Chinese herbal remedies are derived from animal, mineral, as well as arboreous and herbaceous sources. At least 1,500 different herbal drugs have been tested, analysed, and used in Chine... | 343,983 | [
-0.1502546,
0.1135793,
0.3077413,
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0.1197223,
0.04832755,
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0.3648104,
0.4211687,
-0.1270621,
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0.0585554,
0.3791203,
0.04657334,
-0.7716762,
0.009211785,
-0.1708106,
0.1846572,
0.1759934,
0.3654637,
0.2012382,
0.1462811,
-0.4299609,
-0... |
Is vitamin E involved in the autoimmune mechanism? | Autoimmune diseases are characterized by an alteration of the body's defense mechanism, designed for protection against infections and toxic injuries, which for unknown reasons attacks and destroys normal tissue. Some evidence strongly suggests that such diseases are the result of hydrolytic enzymes that escape from ly... | 343,998 | [
-0.2386675,
-0.3079019,
0.3162703,
-0.03328419,
0.2364118,
-0.1251303,
-0.1606399,
0.08727821,
0.1546781,
0.1884174,
0.2866176,
0.01221576,
-0.001522735,
-0.05212319,
-0.1858468,
0.1654812,
-0.4081299,
-0.2720807,
0.06710225,
0.3149833,
0.1073552,
0.06485187,
-0.4588632,
... |
Tolmetin in osteoarthrosis of the hip and knee: double-blind crossover trials. | A double-blind crossover study was carried out in 24 patients with osteoarthrosis of the hip or knee to compare the efficacy of a 1200 mg tolmetin daily dose with a 600 mg daily dose, each given for 2 weeks. Both regimens were well tolerated and appeared to give satisfactory relief of pain, but no differences in respon... | 343,992 | [
-0.01248773,
-0.09035254,
-0.04214922,
-0.1765899,
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-0.4590055,
-0.2615601,
0.1132846,
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-0.310187,
0.0645614,
0.08519128,
0.5077575,
-0.1766446,
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-0.2013052,
0.1713559,
-0.05611452,
0.01945579,
0.1075297,
0.07083677,
-0.15305... |
Coexistent bullous pemphigoid and systemic lupus erythematosus. | A case of coexistent bullous pemphigoid and systemic lupus erythematosus is reported. Evidence for an immunologic pathogenesis is reviewed for both disorders. It is suggested that the coexistence of bullous pemphigoid and systemic lupus erythematosus may represent a similar pathomechanism. | 344,000 | [
0.02324462,
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0.01382567,
-0.09809525,
0.1851533,
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-0.2164742,
0.2145896,
0.0008041338,
0.2370426,
0.1119292,
0.1543095,
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-0.04794036,
0.071528,
0.2582128,
-0.1527851,
0.2740367,
0.1290267,
0.03530281,
... |
Immunofluorescence localization of thyroglobulin autoantibody producing cells in various organs of obese strain (OS) chickens. | All major lymphoid organs from animals of the Obese strain (OS) of chickens which develop a spontaneous autoimmune thyroiditis with circulating thyroglobulin autoantibodies (Tg-AAb) were investigated for Tg-AAb producing cells using the immunofluorescence method (IF). No Tg-binding cells could be detected in spleen, bu... | 344,076 | [
0.2049809,
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-0.4193763,
-0.2650833,
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0.04649819,
0.04336014,
0.09219919,
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0.08009586,
0.1447587,
0.2360339,
0.1162533,
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-0.4039865,
-0.07315271,
-0.03371773,
0.151155,
0.070375,
0.2162741,
-0.3249092,
... |
A phase I study of a multi-modal schedule with Corynebacterium parvum. | A Phase I study of an immuno-chemotherapy regime was carried out using C. parvum as an immune-modulator. 14 women were studied. All received doses of C. parvum ranging from 2.5 mg to 21 mg administered in 1 litre of dextrose saline over 4 h. No evidence of tumour enhancement was observed. | 344,102 | [
-0.2477996,
-0.001798187,
-0.1892119,
-0.2376162,
-0.3063928,
-0.3511413,
-0.4157132,
0.09508657,
-0.02721508,
0.09501072,
-0.1653655,
0.2134608,
0.107528,
0.2642704,
-0.2245141,
-0.2880153,
-0.219061,
0.06613854,
-0.03838618,
0.3030373,
0.2042281,
0.4081128,
0.2038389,
... |
Clinical experience in the use of C. parvum in the treatment of locally advanced carcinoma of the breast. | Twenty-one patients with locally advanced breast cancer which had failed to respond to conventional therapy have been treated by infusion of C. parvum (strain CN 6134, Wellcome Research Laboratories) in 5% Dextrose. Thirteen patients had a single dose of 15 mg. C. parvum over 4 h and 8 patients received 5 daily infusio... | 344,104 | [
-0.2282943,
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-0.2728704,
-0.4801287,
-0.3761954,
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0.1480557,
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0.2448649,
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0.1844394,
0.1544779,
-0.2924102,
0.04510946,
-0.08288218,
0.2472019,
-0.3235519,
0.0853672,
-0.02801428,... |
C. parvum clinical protocols: prototypes and summary results in U. S. trials with Wellcome Coparvax. | Clinical investigations utilizing Wellcome C. parvum in cancer therapy number more than one hundred in multiple institutions. Multiple diseases in various stages are being attacked by multi-modality therapy, making the role of immunotherapy very difficult to assess. Fundamental laboratory observations have suggested wa... | 344,109 | [
-0.3243835,
0.09616924,
-0.1793594,
-0.5046743,
-0.1170898,
-0.4474317,
-0.3812509,
0.1775298,
0.02652103,
-0.02069751,
-0.1244339,
0.1140809,
0.3472149,
0.2679557,
-0.2139976,
-0.3779853,
0.02931375,
-0.1110952,
-0.2549634,
0.3057696,
-0.09292875,
0.3453872,
-0.0501977,
... |
Protective effect of metronidazole in experimental ulcerative colitis. | Administration of carrageenan to guinea pigs produces colonic lesions which are similar to those noted in idiopathic ulcerative colitis of human beings. This model was used to determine fecal flora changes and response to antimicrobial probes during the evolution of carrageenan-induced colitis. The results of fecal flo... | 344,126 | [
0.07961728,
-0.01236298,
-0.1348678,
0.1995669,
0.2408362,
0.002676003,
0.1673025,
0.1088078,
0.2425451,
-0.3673799,
-0.1728123,
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0.02211442,
0.1682075,
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-0.06231801,
-0.5052327,
0.1738925,
-0.1275899,
0.201475,
-0.02027931,
0.1619089,
-0.09462173,
... |
Enrichment for the globin coding region in a chromatin fraction from chick reticulocytes by endonuclease digestion. | A nuclease-sensitive fraction was obtained from chick reticulocyte chromatin by brief digestion with an endonuclease (DNAase II, deoxyribonucleate 3'-oligonucleotidohydrolase, EC 3.1.4.6). The nuclease-sensitive fraction typically contained less than 1% of the chromatin-DNA but about 50% or more of the nascent chromati... | 344,138 | [
0.1103251,
0.2189129,
-0.3239253,
-0.01927003,
0.1015085,
-0.2353808,
-0.01830903,
-0.09869362,
0.0624012,
0.03756867,
0.02194977,
0.09509651,
0.02835154,
-0.08670483,
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0.07231749,
-0.7031357,
0.1947683,
0.2796061,
-0.0604757,
0.4819112,
0.1307482,
-0.2479363,
... |
Escherichia coli antibodies in patients with inflammatory bowel disease. | Sera from 30 patients with inflammatory bowel disease (IBD) (16 with Crohn's disease (CD) and 14 with ulcerative colitis (UC) were assayed for the presence of antibodies against 159 Escherichia coli O-antigens and compared with sera from 16 matched control subjects. The majority of patients with IBD had agglutinating a... | 344,155 | [
-0.04797863,
0.1463763,
0.1166643,
0.02107701,
-0.0920776,
-0.3339668,
0.1069434,
0.2944954,
-0.06678436,
0.1562612,
0.185807,
0.1025476,
0.3393001,
-0.08012631,
-0.4372163,
0.02106193,
-0.1923301,
0.1305866,
0.1210223,
0.09469049,
-0.05311403,
0.1524785,
-0.2080431,
0.... |
Role of mouse IgG and IgE homocytotropic antibodies in passive cutaneous anaphylaxis. | The role of the mouse homocytotropic antibodies in passive cutaneous anaphylaxis reaction was investigated. One class of antibody was heat stable, detected at 2 h but not at 48 h after passive transfer, and belonged to a sublcass of mouse IgG. The other was heat labile, detected at 2 h and 48 h after passive transfer, ... | 344,200 | [
-0.01401513,
-0.09372527,
-0.1340864,
-0.2840541,
0.2485347,
0.004531699,
0.2600159,
0.06112845,
0.001482574,
0.2245157,
0.2772784,
0.1795479,
0.1682537,
-0.1624507,
-0.19349,
-0.1582316,
-0.06264699,
-0.1498402,
-0.2467231,
0.02466649,
0.257358,
0.1012782,
0.02684715,
... |
Eosinophil chemotactic factor (ECF). III. Generation in human peripheral leukocytes. | Eosinophil chemotactic factor (ECF) can be released from human peripheral leukocytes by an IgE-anti-IgE reaction, by the calcium ionophore A 23187 and during phagocytosis. Supernatants and sonicates of unstimulated cells contain little or no ECF. On stimulation, however, ECF activity increases in the cells and even mor... | 344,230 | [
-0.1373632,
0.1315339,
-0.3290436,
-0.2407673,
0.6224186,
-0.09630245,
-0.02067937,
0.04134059,
-0.03597845,
-0.1605552,
-0.2026924,
0.2648028,
0.05209497,
-0.02463679,
-0.4404662,
-0.005817472,
-0.5278388,
0.1365128,
0.04543331,
0.321281,
0.3005147,
0.1361404,
-0.3542039... |
Acupuncture in the treatment of addiction: a review and analysis. | Many claims have been made about the usefulness of acupuncture as an analgesic and in the cure of certain conditions. The background of some of these claims is examined as are alternative hypotheses for some of the observations that have been reported. The studies that have served as the basis of much of what has been ... | 344,235 | [
-0.05055609,
0.2177498,
-0.03275578,
0.07139587,
0.07361298,
-0.07352494,
-0.4165134,
0.03780295,
-0.03597227,
-0.07001967,
0.1127543,
0.1468127,
0.003906108,
0.003577677,
-0.2558798,
0.07997797,
0.01294835,
0.2853779,
-0.2861683,
-0.04280621,
-0.2295483,
0.04089097,
-0.1... |
A closed submucous cervical suture for the incompetent cervix. | Twenty-five consecutive cases of cervical incompetence were treated by a closed submucous cervical suture that I developed. Twenty patients proceeded to term and delivered live babies. This was statistically significant when compared to their own reproductive performance before operation (P less than 0.001). The suture... | 344,251 | [
0.1340131,
0.01176493,
-0.148635,
-0.07879752,
0.04660934,
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0.02613311,
0.1764617,
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0.2534045,
0.2559063,
-0.1494258,
-0.289042,
-0.5587597,
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-0.4550832,
-0.09417796,
-0.2507778,
-0.1419798,
0.4921713,
-0.02341806,
-0.073663... |
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