title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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The electroencephalogram in dementia. | The EEG in normal aging and in dementia due to a variety of diseases has been described. In dementia due to degenerative diseases, metabolic disorders, normal pressure hydrocephalus, and deficiency states, the diffuseness of the abnormalities observed has been emphasized; whereas with cerebrovascular disease and with i... | 336,273 | [
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The pathogenesis of immune thrombocytopenic purpura. | Chronic idiopathic thrombocytopenic purpura (ITP) is a human disease manifested by destructive thrombocytopenia due to a circulating antiplatelet antibody. The antibody is of IgG type and is produced primarily in the spleen and bone marrow. After binding of the antibody to a platelet-associated antigen, phagocytosis i... | 336,282 | [
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The analysis of essential oils and extracts (oleoresins) from seasonings--a critical review. | A critical review of the analytical methods employed for the determination of the relevant components of seasonings is presented. Where the available methods were inadequate, new ones have been devised. Particular emphasis has been placed on those methods of analysis that provide a rapid and sufficiently accurate appra... | 336,288 | [
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The involvement of protein L16 on ribosomal peptidyl transferase activity. | Radioactive ribosomes from Escherichia coli were treated with increasing concentrations of NH4Cl in the presence of 50% ethanol. The resulting particles were tested for peptidyl transferase activity as well as for the binding of (U)C-A-C-C-A-Leu-Ac, (U)C-A-C-C-A-Leu, chloramphenicol, lincomycin and erythromycin. At the... | 336,360 | [
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Immunodetection of a human chorionic gonadotropin-like substance in human sperm. | The presence of a human chorionic gonadotropin (hCG)-like substance in human spermatozoa is reported. A highly sensitive immunocytochemical procedure was utilized (double-antibody immunofluorescence technique). Rabbit anti-hCG or rabbit anti-hCG beta-subunit was used as the first antibody. A positive fluorescence react... | 336,416 | [
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Tolerance to lactose among lactase-deficient American Indians. | To determine the amount of lactose that could be tolerated in a meal, 59 lactase-deficient American Indians, ranging in age from 5 to 62, were given graded doses of lactose. The diagnosis of lactase deficiency had beeen documented previously by showing increased breath hydrogen after an oral lactose load (2 g per kg, m... | 336,450 | [
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[Effects of pretreatment with carteolol on metabolic changes induced by coronary artery ligation in dog left ventricular wall (author's transl)]. | Effects of coronary artery ligation on myocardial glycogenolysis were studied in the endo- and epicardial layers of the left ventricular wall in dogs pretreated with 10 or 100 microgram/kg (i.v.) of carteolol, a potent beta-adrenergic blocking agent. Coronary artery ligation was performed by ligating one of the small b... | 336,485 | [
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Effect of phosphate on ergot alkaloid synthesis in Aspergillus fumigatus. | High concentration of inorganic phosphate in the culture medium of Aspergillus fumigatus inhibited ergot alkaloid synthesis. Addition of L-tryptophan but not mevalonate or 5-methyltryptophan to the above culture restored the alkaloid synthesis to the level found in normal cultures. The decrease in alkaloid synthesis in... | 336,488 | [
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The adoptive secondary response to human serum albumin under conditions of high antigen pressure. The response of high and low avidity B cell subsets. | Thoracic duct lymphocytes (TDL) from (AS2 x AS)F1 rats previously injected with human serum albumin (HSA) were transferred to 900 r irradiated syngeneic recipients which were challenged with various doses of soluble HSA (s-HSA). TDL from partially tolerant rats, which were deficient in high avidity B cells, produced a ... | 336,520 | [
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IgG anti-hapten antibody secretion in vitro commences after extensive precursor proliferation. | We have investigated whether the intermediate cells that arise in primed mice after boosting require further cycles of division in culture before maturation into IgG antibody secreting cells. Killing of dividing cells between days 1--4 in culture, by exposure to BUdR-uv irradiation ablated the high IgG response observe... | 336,521 | [
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Liability to hydrophobic and charge interaction of smooth Salmonella typhimurium 395 MS sensitized with anti-MS immunoglobulin G and complement. | Sensitization of smooth Salmonella typhimurium 395 MS bacteria with hyper-immune anti-MS immunoglobulin G (IgG) antibodies increased the liability to hydrophobic interaction as assessed by the affinity for a column of Octyl-Sepharose. After sensitization, the material originally eluted with 1 M (NH4)SO4 in a 0.01 M pho... | 336,538 | [
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Surgical pocket therapy. | (1) Periodontal pockets can be treated successfully by several modalities of surgery. (2) Periodontal pocket walls do not have to be eliminated surgically in order to stop the progress of periodontal disease. (3) A residual defect which can be probed beyond 3 mm at the site of a previous peridontal pocket, does not sig... | 336,552 | [
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Reduction of Salmonella and fecal contamination of pork during swine slaughter. | Experiments were designed to reduce Salmonella and fecal contamination of pork, using several sanitizing methods and agents. Sanitizing the hauling vehicle and holding pens with chlorine or quaternary ammonium compounds proved ineffective in reducing carcass contamination. When the eviscerator wore a plastic glove and ... | 336,588 | [
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Yersiniosis in captive exotic mammals. | Within a 2 1/2-month period, Yersinia pseudotuberculosis infection occurred in 3 blesbok (Damaliscus dorcas), 1 dik-dik (Madoqua kirkii), and 1 giant anteater (Myrmecophaga tridactyla) at the National Zoological Park, Washington, DC. Lesions consisted of fibrinonecrotic enteritis and peritonitis, mesenteric lymphadenit... | 336,591 | [
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Differentiation of rennet from other milk-clotting enzymes by polyacrylamide gel electrophoresis. | Polyacrylamide gel electrophoresis was used to differentiate animal rennet and other milk-clotting enzymes. After electrophoresis, the separated components were visualized by staining with aniline blue-black. Two prominent proteins were found in calf and bovine rennet, while only 1 major protein was observed in pepsin ... | 336,596 | [
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Thymineless death in Escherichia coli dnaB mutants and in a dnaB dnaG double mutant. | The interference of dnaB mutations of Escherichia coli with thymineless death is described. All the isogenic Thy- dnaB mutants of E. coli we have tested show a remarkable immunity towards cell death induced by thymine deprivation at the nonpermissive temperature. We have also constructed and tested an isogenic double d... | 336,604 | [
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Purification and characterization of active component and active fragment of colicin E3. | 1. Two components of colicin E3, namely proteins A and B, were prepared by means of an improved method. 2. Protein A thus obtained was more than a thousand times as active as native colicin E3 when they were assayed in terms of activity for ribosome inactivation. 3. Protein A was reconstituted to colicin E3 simply by m... | 336,615 | [
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Changes in phospholipids of Saccharomyces cerevisiae associated with inositol-less death. | Two inositol-requiring strains of Saccharomyces cerevisiae were examined for changes in levels of phospholipids occurring after inositol deprivation. Lack of inositol results in loss of cell viability (inositol-less death) and in very large increases in two phospholipid precursors, phosphatidic acid and CDP-diacylglyce... | 336,620 | [
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Purification and some novel properties of Escherichia coli RNase II. | RNase II of Escherichia coli (EC 3.1.4.23) has been purified to apparent homogeneity. The K+-activated diesterase activity against poly(U), which defines RNase II, cochromatographs with activity against T4 mRNA or pulse-labeled E. coli RNA successively on DEAE-cellulose, hydroxyapatite or phosphocellulose, and Sephadex... | 336,625 | [
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Experience with a "continuous" laser in the treatment of suitable cutaneous conditions: preliminary report. | A clinical trial with a "continuous" CO2 laser in the treatment of cutaneous lesions was instituted 2 1/2 years ago. The laser was used as a "light" knife for excision and for gross destruction of some lesions directly. Details of technique and a preliminary report assessing clinical results and general effects are giv... | 336,667 | [
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Delayed flexor tendon repair in no man's land. | Thirty seven digital flexor tendon injuries in 31 patients were treated by closure of the skin and delayed repair from 24 hours to 21 days later. All skin wounds healed without serious complication, and there were no infections. On examination at a minium of 4 months after repair, 36% had total active motion (TAM) of 2... | 336,676 | [
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G.H. Mead's social behaviorism. | This paper seeks to clarify those conceptual foundations of G.H. Mead's social behaviorism which are assumed, but not made explicit, in that writer's well-known volume Mind, Self and Society. These foundations are shown to be an outgrowth of Mead's early commitment to the organic conception of conduct underlying the ps... | 336,677 | [
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Two-wavelength cytophotometry: the choice of the wavelengths from a practical point of view. | Methods in use for the choice of the two-wavelengths and the effect of a faulty choice of the two wavelengths in the two-wavelength cytophotometric method of Patau and Ornstein are studied by means of a computer simulation and in practice upon pararosaniline-Schiff stained nuclei. A simplification of the measuring stra... | 336,786 | [
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Microbiological evaluation of South Australian rock lobster meat. | Samples of frozen precooked rock lobster meat from five South Australian fish-processing plants situated in the West Coast and south-east regions were tested over a period of six months during the 1974/5 lobster fishing season. The most probable number (MPN) of E. coli and coliforms, Staphylococcus aureus and Salmonel... | 336,790 | [
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'Malignant lymphoepithelial lesions' (undifferentiated ductal carcinomas of the parotid gland). Three case reports and review of the literature. | Three cases of the so-cassed malignant lymphoepithelial lesion occurring in women are described. The authors, however, prefer to label the lesion 'undifferentiated carcinoma of the parotid'. From an accurate review of the world literature it appears that 23 cases of such lesion have been reported, 22 arising in the par... | 336,820 | [
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A priming effect of luteinizing hormone releasing factor with respect to release of follicle-stimulating hormone in vitro and in vivo. | Pituitary incubation studies were carried out which showed that in the rat luteinizing hormone releasing factor (LH-RF) can exert a priming effect on FSH secretion in vitro. It was found that, as for LH, the effect depends on protein synthesis. The priming effect of LH-RF with respect to FSH could also be demonstrated ... | 336,830 | [
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Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice. | The absolute frequencies of B cells-producing A5A idiotype have been determined in vitro by limiting dilution analysis in a culture system in which every LPS-reactive B cell grows into a clone of IgM-secreting cells. Spleen cells from normal A/J mice contain 1 A5A-idiotype-producing B-cell precursor in 2.5 X 10(3) LPS-... | 336,835 | [
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Effect of a polyene antibiotic on growth and phosphate uptake by Candida albicans. | The polyene antibiotic, amphotericin, inhibited phosphate uptake in Candida albicans more strongly than it inhibited growth. Cultures grown from an inoculum of young (2 h) cells were more affected than those inoculated with old (24 h) cells. Thus, the polyene displays a double effect on C. albicans (and presumably on o... | 336,844 | [
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[Combined trephining with scleral flap (Elliot-Fronimopoulos) and intracapsular cataract extraction (author's transl)]. | 68 eyes of 51 non-selected patients on which a combined cataract extraction and Elliot's trephining with scleral flap (Fronimopoulos) had been performed between 1972 and september 1976, were re-examined between 6 and 48 months following operation. Postoperative complications were rare: there was one persistent shallow ... | 336,973 | [
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[On the treatment of acute arterial circulatory disturbances of the retina and optic nerve (author's transl)]. | After discussing basic therapeutic principles for the treatment of acute arterial occlusions of the retina and N. opticus (fibrinolysis, anticoagulation, corticoids, vasoactive drugs) the problems in employment of vasodilating drugs and the necessity of concomitant administration of strophanthine or digitalisglycosides... | 336,975 | [
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The advantage of heterotopic cardiac transplantation over orthotopic cardiac transplantation in the management of severe acute rejection. | The major problems with organ transplantation are rejection of the allograft and the side effects of antirejection therapy. This report describes the successful treatment of a patient in whom rejection of the donor heart developed 10 months after implantation. The recipient's own heart had been left intact and was able... | 336,984 | [
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Replication of plasmid pSC101 in Escherichia coli K12: requirement for dnaA function. | Replication of pSC101 was analyzed by using DNA-DNA hybridization and alkaline sucrose gradient centrifugation. Mutants of the dnaA gene were tested for their capacity to replicate pSC101 DNA at a non-permissive temperature. Only a small amount of radioactive precursor was incorporated into pSC101 DNA in dnaA mutants a... | 337,104 | [
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Genetic studies of hybrids between coliphage lambda and salmonella phage P22: genetic analysis of the P22-lambda hybrid class. | P22-lambda hybrids which retain the protein coat of P22 have been isolated and characterized into two types. Type 1 hybrids which have the c through O-P genes of lambda are unable to grow lytically on Salmonella typhimurium. On the other hand, type 2 hybrids which contain only the c region of lambda, plated on S. typhi... | 337,122 | [
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Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. | Overweight patients with uncomplicated essential hypertension were followed up biweekly for six months: 24 not receiving antihypertensive-drug therapy (Group I) and 83 on regular but inadequate (despite drug manipulation) antihypertensive-drug therapy (Group II). All patients in Group I and 57 randomly selected patient... | 337,144 | [
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Histologic fate of tympanic membrane and ossicle homografts. | 1. The biologic behavior and usefulness of homologous incus grafts preserved in Cialit compare favorably with that of ossicular autografts. 2. Reconstruction of the transplanted incus correlates with the period of its immersion in preservative: the briefer the period of exposure to fixative, the more rapidly resorption... | 337,217 | [
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The services of a hospital medical library. | The purpose of a hospital medical library is described under the headings of diagnostic and treatment guide, current awareness and access to published literature. The Wessex Regional Library and Information Services is described. | 337,263 | [
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Differential lateral mobility of IgM and IgG receptors in mouse B lymphocyte membranes. | Anti-Ig induced redistribution of different Ig subclasses was studied as a function of temperature and correlated with membrane phase transitions as revealed by electron spin resonance spectroscopy. Fluorescein isothiocyanate-coupled anti-IgG2 and anti-IgM antibodies induced patching and capping that proceeded with inc... | 337,299 | [
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Escherichia coli ribosomal protein S1 has two polynucleotide binding sites. | The interaction of Escherichia coli ribosomal protein S1 with a variety of RNA and DNA oligomers and polymers has been studied, using both a sedimentation technique and the quenching of intrinsic protein fluorescence upon nucleic acid binding to obtain equilibrium binding parameters. Two polynucleotide binding sites ha... | 337,301 | [
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New drugs in the treatment of pituitary disorders. | Because of the poor results and the morbidity associated with surgical and radiation treatment of pituitary adenomas, investigators continue to search for new pharmacologic tools to treat anterior pituitary hyperfunction. New drugs are being studied in the treatment of acromegaly, Cushing's disease, and galactorrhea-am... | 337,337 | [
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[Notes on the phlebologic work of Jean-Daniel Martinet]. | In homage to J.D. Martinet, the author, who was his collaborator for more than 25 years, surveys his phlebological work, so diverse and so multiple that it embraces all subjects of the venous pathology of the lower limbs. He cites 3 representative examples on different levels: the information and practical conclusions ... | 337,333 | [
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Oxidation of various substrates by host grown Mycobacteria leprae and M. lepraemurium. | Oxidation of various substrates by whole cell suspensions of M. Lepraemurium and M. leprae was investigated using manometric techniques. Yeast extract, L-cysteine, dithioerythritol, and DL-penicillamine were oxidized by both M. lepraemurium as well as by M. leprae. Although tween 80 was oxidized by M. lepraemurium cell... | 337,415 | [
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[Iron overload: effect on specific and nonspecific immunity]. | Acute overload with an iron salt in mice enhanced the virulence of a relatively avirulent type of Salmonella typhimurium in a dose-dependent fashion. Iron administration also partly abolished specific immunity. Ferritin iron did not display the virulence-enhancing effect. | 337,471 | [
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The chemotherapy of tuberculosis--a personal overview. | The story is told of how streptomycin, PAS and isoniazid came to be known as the first-line drugs. Although the present first line is generally accepted as rifampicin, ethambutol and isoniazid, the way in which these drugs should be used in different types of tuberculosis and in different parts of the world is discusse... | 337,481 | [
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Mediastinal cyst containing mural pancreatic tissue. | The second documented case of mediastinal ectopic tissue presenting as a mediastinal mass is reported. Previously reported cases of ectopic pancreatic tissue in the thorax are reviewed in an attempt to explain this anomalous development. | 337,563 | [
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Hepatitis syphilitica. A clinico-pathological study of 25 cases. | Specific histological alterations have been observed in 23 of the 25 patients with early syphilis with laboratory findings suggesting liver damage. Treponema has been detected in the areas of liver lesion in 70 per cent of the patients. Control examination carried out after penicillin therapy showed regression of the a... | 337,744 | [
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The effect of doxapram on buprenorphine induced respiratory depression. | Doxapram administered as a single injection or infusion satisfactorily counteracted the respiratory depression produced by buprenorphrine when administered one hour after the analgesic in healthy subjects. The respiratory stimulant effect was relatively short lived, however, a more prolonged effect was found by study o... | 337,748 | [
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Monitoring the critically ill surgical patient. | This review has focused on several aspects of monitoring the critically ill patient. A few of the more commonly used monitoring devices have been discussed to emphasize that their use carries some risk. Because of this, proper indications, based on the benefits to be achieved, must be available before they are used. Gu... | 337,778 | [
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Man or machine in psychiatric diagnosis. | The authors describe the previous studies of the stability of psychiatric diagnoses over time that have found such diagnoses to be unreliable, stating that the assumptions underlying these studies have been tested and disproved. On the other hand, the use of standardized interview techniques and categorization by compu... | 337,813 | [
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Factors governing the emergence of resistance to nalidixic acid in treatment of urinary tract infection. | Cultures of Escherichia coli were exposed to nalidixic acid in an in vitro model in which the conditions of drug-organism interaction resembled those of bacterial cystitis treatment. Results obtained in this way suggested that emergence of bacterial resistance should not be a major problem in treatment of uncomplicated... | 337,890 | [
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L-Histidine production by histidase-less regulatory mutants of Serratia marcescens constructed by transduction. | 2-Methylhistidine (2MH) and 1,2,4-triazole-3-alanine (TRA) inhibited the growth of Serratia marcescens. These inhibitory effects were counteracted by L-histidine. Enzymatic studies showed that 2MH acts as a false feedback inhibitor and TRA acts as both a false feedback inhibitor and a repressor. Mutants resistant to ea... | 337,893 | [
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Rapid identification and quantitation of small numbers of microorganisms by a chemiluminescent immunoreaction. | A method (patent pending) for rapidly identifying and quantitating small numbers of microorganisms was developed based on the specific immunoreaction of microorganisms with homologous antibodies linked by conjugation to peroxidase. The high sensitivity of the method is due to the use of a chemiluminescent reaction for ... | 337,894 | [
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Double-antibody solid-phase enzyme immunoassay for the detection of staphylococcal enterotoxin A. | A simple double-antibody enzyme immunoassay that uses a microtechnique was developed for detecting staphylococcal enterotoxin A in food products. Sample preparation can be completed in less than 15 min. Assay sensitivity ranges from 0.4 ng (20-h test time) to 3.2 ng (1- to 3-h test time) of toxin per ml of prepared sam... | 337,898 | [
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Comparative dose-survival curves of representative Clostridium botulinum type F spores with type A and B spores. | Radiation survival data of proteolytic (Walls 8G-F) and non-proteolytic (Eklund 83F) type F spores of Clostridium botulinum were compared with dose-response data of radiation-resistant type A (33A) and B (40B) spores. Strain Eklund 83F was as resistant as strain 33A, whereas strain Walls 8G-F was the most sensitive of ... | 337,901 | [
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Endocarditis with myocardial abscesses and pericarditis in an adult: group B Streptococcus as a cause. | Group B beta-hemolytic Streptococcus, S agalactiae, is an uncommon cause of endocarditis in adults. We present the clinical, laboratory, and postmortem findings of an adult patient with group B streptococcal endocarditis and major arterial emboli. What to our knowledge are previously unreported features are purulent pe... | 337,917 | [
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In vivo and in vitro studies on the glucose dependent inactivation of yeast cytoplasmic malate dehydrogenase. | The cytoplasmic malate dehydrogenase in the yeast Saccharomyces cerevisiae is known to be inactivated by a glucose dependent process. In this paper it is shown that in vivo effectors of the glucose metabolism (arsenate, iodoacetate, acetaldhyde) inhibit the inactivation or change the inactivation kinetics. In vitro it ... | 337,921 | [
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-0.1827849,
0.2975316,
0.3727246,
0.2754498,
0.1145547,
0... |
The role of easily released substances (ERS) from bacteria in physiologic solution in natural immunity. VI. Induction of opsonins for different genera of bacteria by ERS from Staph. aureus oxford. | ERS obtained from Staph. aureus by mild extraction with physiologic saline solution possess activity of inducing nonspecific opsonins which react with homologous bacteria and with related Gram-negative bacteria. ERS from Staph. aureus weakly stimulated precipitins and antibodies active in passive hemagglutination and i... | 337,934 | [
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0.0430599,
0.1068225,
-0.1600782... |
[Characteristics of the ultrastructural changes of the large intestine mucosa after acute dysentery]. | Electron microscopic examinations of biopsy specimens of the large intestine from 8 patients one month after termination of the acute phase of dysentery revealed dystrophic and destructive changes in surface epithelium cells consisting in the lack of glycocalyx, fragmentation of microvilli, vacuolation and subsequent h... | 337,939 | [
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0.2522165,
0.1397522,
0.01145287,
... |
Corneal rings with gram-negative bacteria. | Corneal rings have been described with corneal ulcerations caused by Gram-negative bacteria. Corneal rings were produced by intracorneal injections of viable Pseudomonas aeruginosa as well as heat-inactivated suspensions of Gram-negative bacteria (P aeruginosa and Escherichia coli) but not Gram-positive bacteria (Staph... | 337,946 | [
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0.1637336,
0.01051753,
0.3306581,
0.3385236,
0.0211... |
Transitory IgA-deficiency, persistent IgE deficiency and recurrent respiratory tract infectious disease after splenectomy. | In a 14 year old boy, a ruptured spleen was removed. Two months after the splenectomy he developed recurrent infections of the respiratory tract. A deficiency of IgA and IgE in his blood serum was found. His impaired resistance to respiratory tract infections responded well to substitution therapy with IgA. Spontaneous... | 337,948 | [
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The migrant cells in allotransplants of heart, kidney and skin. II. Monocyte-macrophage activity. | Within a few hours of transplantation the cells of the mononuclear phagocyte system migrate into the interstitial tissues of the organ. The cells arrive on the vascular endothelium of the allotransplanted organ either as macrophages or as monocytes but on entering the interstitial tissues they begin to enlarge, differe... | 338,013 | [
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0.1931292,
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0.001151129,
0.4393477,
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-... |
Heavy meromyosin binds actin with negative cooperativity. | The association of fluorescently labeled heavy meromyosin (HMM) and F-actin was measured by time-resolved fluorescence depolarization. The effects of varying the protein concentrations, temperature, KCl concentration, and pH were determined. Measurements of HMM mobility supported a model of no interaction between the t... | 338,033 | [
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0.1433268,
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0.06181601,
0.6370826,
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0.1110... |
Antidepressant drug therapy in psychotic depression. | Imipramine and phenelzine were ineffective in the treatment of five primary unipolar depressives with delusions, even when plasma levels of imipramine and desmethylimipramine or activity of platelet monoamine oxidase suggested that an adequate dose of drug had been given. Four patients went on to receive ECT and all re... | 338,082 | [
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0.2921564,
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0.1590189,
0.02339537,
... |
The use of double renal transplants from paediatric cadaver donors. | In 224 consecutive kidney transplantations, 3 patients, aged 44, 37 and 13 years received double renal transplants from paediatric cadaver donors aged 1 day, 23 and 19 months respectively. Both adult recipients developed severe hypertension during postoperative rejection crises leading to multiple graft ruptures in the... | 338,086 | [
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0.1495003,
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0.3214912,
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... |
Breast metastasis: an unusual manifestation of a malignant carcinoid tumor. | A metastasis from a bronchial carcinoid tumor presented as an isolated breast mass in a 58-year-old female. A review of the English literature revealed four cases of metastatic carcinoid to the breast that presented as an isolated breast mass. In each case, radical mastectomy was performed after the lesion had been int... | 338,142 | [
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0.1261675,
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... |
Ultrastructural identification of a new cell type--the N-cell as the source of neurotensin in the gut mucosa. | The neurotensin-cell is identified immunohistochemically and ultrastructurally by differential counting of endocrine cells in the gut of a primate (Tupaia belangeri). Utilizing light microscopy, the EC-cells are identified by the Masson-Fontana silver stain; with the same method the neurotensin cells are not stained. T... | 338,160 | [
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-... |
alpha-1-Antitrypsin immunoreactivity in islet cells of adult human pancreas. | alpha-1-antitrypsin immunoreactivity was demonstrated by immunofluorescence technique in the peripheral islet cells of all ten normal adult human pancreata examined; normal adult human liver was negative. The specificity of the reactions was confirmed by applying various control tests including absorption of the specif... | 338,161 | [
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Variations in structure and function during the life cycle of malarial parasites. | The fine structure of malarial parasites is reviewed and the function of the intracellular organelles is discussed. When the erythrocytic, exoerythrocytic, and mosquito stages of plasmodia are compared, substantial differences are seen. The major differences involve the amount of surface coat of the motile forms, the s... | 338,177 | [
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0.106318,
0.2444772,
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... |
Evaluation of homogeneous enzyme immunoassay of serum thyroxine with use of bichromatic analysis. | We evaluated the homogeneous enzyme immunoassay ("EMIT") of serum thyroxine with use of an ABA- 100 Bichromatic Analyzer, modified with an auxiliary dispenser syringe and a dual probe assembly. The modification allows two reagents to be dispensed at one time. The sera must be pre-treated with 0.1 mol/liter NaOH. The pr... | 338,200 | [
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0.1890192,
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... |
Homogeneous enzyme immunoassay for cannabinoids in urine. | We describe a homogeneous enzyme immunoassay for measurement of cannabinoid metabolites, as well as delta9-tetrahydrocannabinol (I) in urine. Malate dehydrogenase from pig heart mitochondria was labeled with a derivative of I. The compound used to calibrate the assay was the I metabolite, 11-nor-delta9-tetrahydrocannab... | 338,202 | [
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0.2075262,
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0.... |
Study of the effects of bromocriptine on sexual impotence. | Serum testosterone, prolactin, LH, FSH and plasma 17 beta-oestradiol levels were determined in forty-seven male patients with sexual impotence. Low testosterone values and slightly elevated prolactin levels were observed in 19% and in 17% of cases, respectively. Since sexual function in the male seems to be controlled ... | 338,206 | [
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0.2297801,
0.2269339,
0.3187665,
0.0044157... |
Controlled telethermographic study of the peripheral vasoactivity of oral piribedil. | A single-blind crossover study was carried out in 10 subjects with a healthy arterial system to compare the effects of oral piribedil and placebo on the peripheral circulation. Using a telethermographic technique, skin temperature variations from baseline values were measured, at 15 minute intervals over a 2-hour perio... | 338,254 | [
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0.09740295,
0.00243607,
0.3416944,
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... |
A double-blind trial of feprazone in osteoarthritis of the hip. | A double-blind crossover study was carried out in 21 patients with osteoarthrosis of the hip to compare the efficacy and tolerance of feprazone (600 mg/day) and ibuprofen (1200 mg/day), each drug being given for 4 weeks. No statistically significant changes were noted in any of the objective parameters measured, but pa... | 338,255 | [
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0.2748096,
0.02160662,
0.02355929,
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... |
Treatment of fluid retention in cirrhosis: a comparison of bumetanide and frusemide. | Bumetanide and frusemide were compared in a crossover study of 10 patients with cirrhosis and fluid overload. Patients received each drug for 3 months. Doses of bumetide varied from 1 mg on alternate days to 3 mg daily (mean 1.3 mg/day), and for frusemide from 40 mg on alternate days to 160 mg daily (mean 72 mg/day). B... | 338,256 | [
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[Experimental control of the dye dilution method of measuring telediastolic ventricular volume by the steps in the curve of indicator "washing"]. | After a brief discussion on the basis of the dilution method for determination of telediastolic volume (TDV) of the ventricles, the authors described the results from their own experimental studies on 8 nonbred dogs, on whom 186 curves of indicator "washing" (of the dye "Cardiogreen" were recorded, presented on 2 table... | 338,287 | [
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0.2430216,
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0.0774836,
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0.08652098,... |
Reconstitution of model membranes from phospholipid and outer membrane proteins of Proteus mirabilis. Role of proteins in the formation of hydrophilic pores and protection of membranes against detergents. | Outer membrane proteins extracted from isolated cell walls of Proteus mirabilis were able to combine the cell wall phospholipids in a model membrane system. The presence of outer membrane proteins in vesicular model membranes mediated the release of previously entrapped [14C]sucrose while [3H]inulin was retained. Incor... | 338,302 | [
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0.2468665,
0.289132,
0.00005... |
Adenohypophysial necrosis in rats following destruction of the pituitary stalk. A histologic, immunocytologic and fine structural study. | Adenohypophyses of adult male rats have been investigated by light microscopy, immunocytology and electron microscopy 30 minutes, 1, 2, 4, 6 and 24 hours following electrolyte destruction of the pituitary stalk. Light microscopy revealed massive ischemic infarction of the adenohypophysis. Immunoreactive growth hormone,... | 338,335 | [
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0.2237891,
0.402914,
-0.08435807,
0.022960... |
Structure-activity correlations for antibacterial 1,5-benzodiazepine derivatives on gram-positive cells. | The antibacterial activity of a set of 1,5-benzodiazepine derivatives against Staph, aureus and Strep, pyogenes has been correlated with structural features of the compounds examined. It is shown by means of substituent constants and regression analysis that the lipophilic character of the molecule is the most importan... | 338,349 | [
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0.04379665,
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Sequence organization and expression of a yeast plasmid DNA. | Saccharomyces cerevisiae strain A364A D5 contains circular double-stranded DNA molecules of 6230 +/- 30 base pairs (2mu DNA) which are present in 68 copies per cell and make up 2.4% of the haploid genome. About 0.4% of non-poly A containing yeast RNA hybridizes to the yeast DNA circles. When denatured and then self-ann... | 338,416 | [
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0.5358948,
0.1237215,
-0.1192635... |
Thymic-dependent anti-hapten response in congenitally athymic (nude) mice immunized with DNP-thymosin. | Immunization of congenitally athymic (nu/nu) and adult thymectomized, irradiated bone marrow, reconstituted (TxBm) mice with DNP5-thymosin (dinitrophenylated-bovine thymosin fraction 5) was found to elcit IgM and IgG anti-DNP plaque-forming cells in these animals. Further studies indicated that this response was antige... | 338,478 | [
-0.1035382,
-0.2645368,
-0.312045,
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-0.325764,
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0.1691313,
0.09509936,
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-0... |
Role of phagocytosis in mouse virulence of Salmonella typhimurium recombinants with O antigen 6,7 or 4,12. | The quality of lipopolysaccharide has previously been shown to influence the mouse virulence of Salmonella so that strains with O antigen 4,12 were more virulent than their O-9,12 sister strains. Immunosuppression did not alter this O-antigen-dependent difference in virulence. I have now constructed smooth O-4,12 and O... | 338,484 | [
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0.3764875,
0.07818144,
0.1599816,
0.1474035,
-0.279589... |
Failure of endotoxin to protect C3H/HeJ mice against lethal x-irradiation. | C3H/HeJ mice are more sensitive to lethal X-irradiation and cannot be protected by pretreatment with endotoxin, compared to the C3HeB/FeJ strain. Lack of a granulopoietic response in C3H/HeJ mice is evident. | 338,493 | [
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0.4035241,
0.3018727,
0.00192133,
0.0653725... |
Some observations on fuzzy diagnosis and medical computing. | Wechsler has advocated the use of fuzzy logic for medical diagnosis, but it is pointed out that simpler systems have proved more successful than is apparent from his paper. The proposal raises a broad range of issues concerning the role of sophisticated information-processing techniques in the development of medical co... | 338,512 | [
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-0.02186296,
-0.228... |
Potential of the amino acid homology studies: homologies found between beta-galactosidase and lac repressor of E. coli. | Significant amino acid homologies were found between beta-galactosidase fragments and lac repressor of E. coli using a sliding match according to Greller and Erhan (1974). Since both of these proteins can recognise and bind galactose moiety, we propose that the homologous regions represetn galactose binding site(s) on ... | 338,513 | [
0.1757577,
-0.2020633,
-0.1504442,
0.2910247,
-0.05221174,
-0.2168147,
-0.4201409,
-0.07632114,
0.1342628,
-0.02177724,
-0.001984407,
0.202674,
0.128746,
0.002357444,
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0.1686617,
-0.3169171,
0.03354155,
0.1407887,
-0.1751964,
0.3400204,
0.06277286,
-0.2432232,
... |
Bladder response to klebsiella infection: a scanning electron microscopy study. | The early response of rat bladder epithelium to Klebsiella pneumoniae was examined using scanning electron microscopy. Increased bacterial adherence with time after challenge paralleled the occurrence of strand formation and ulceration on the bladder epithelium. The early bladder response to the bacteria consisted of a... | 338,544 | [
-0.06013508,
0.03649214,
-0.1534213,
-0.006260875,
0.1588292,
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0.1718442,
0.2877583,
0.08269698,
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0.1858539,
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-0.2758229,
0.04635707,
-0.1308909,
-0.2135171,
0.3125397,
0.10191,
0.107594,
... |
On the mechanism of the persistence of lymphocytic choriomeningitis virus in the continuous cell line Detroit-6. | A persistent lymphocytic choriomeningitis virus, noninfectious for mice, was revealed in the continuous human cell line, Detroit-6. The virus was detected in the cell monolayer by an indirect immunofluorescence test and in the cell homogenate by a complement-fixation test. Between 30 and 80% of the cells produced viral... | 338,548 | [
-0.0908173,
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-0.06835293,
0.2531892,
0.582466,
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-0.001249504,
0.1235087,
0.3212397,
0.02531861,
0.02182378,
0.08247214,
0.1881769,
0.3230132,
-0.4113849,
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0.2390106,
-0.562674,
0.08778275,
0.2213652,
-0.08617637,
-0.2050863,
-... |
Identification of the Escherichia coli cell division gene sep and organization of the cell division-cell envelope genes in the sep-mur-ftsA-envA cluster as determined with specialized transducing lambda bacteriophages. | From a lysogen with lambda integrated in the leu operon, specialized transducing phages that carry the cell division, murein biosynthesis, and envelope permeability genes located about 0.5 min to the right of leu were isolated. These phages were used to identify the previously undiscovered cell division gene sep. A gen... | 338,600 | [
0.05530239,
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0.03310157,
0.2697878,
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0.004992409,
0.2826115,
0.1528234,
0.01501235,
0.1321159,
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0.2931189,
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0.07657534,
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0.04648355,
0.4739225,
0.1189513,
-0.1707699,
... |
Involvement of 30S ribosomal protein S1 in poly(U)-directed polyphenylalanine synthesis. | The effect of 30S ribosomal protein S1 on poly(U)-directed polyphenylalanine synthesis was studied using a highly purified cell-free system which was devoid of endogenous S1. The system consisted of homogeneous preparations of EF-Tu, EF-Ts, and EF-G, and 70S ribosomes from which protein S1 had been removed by poly(U)-c... | 338,604 | [
-0.08037814,
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0.1423546,
0.05415354,
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0.03788561,
0.2334556,
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0.1565516,
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0.1703947,
-0.3744726,
0.3004582,
0.631155,
0.1220385,
-0.3193805,
-0.094... |
Phagocytosis of bacteria by polymorphonuclear leukocytes. A freeze-fracture, scanning electron microscope, and thin-section investigation of membrane structure. | The changes in membrane structure of rabbit polymorphonuclear (PMN) leukocytes during bacterial phagocytosis was investigated with scanning electron microscope (SEM), thin-section, and freeze-fracture techniques. SEM observations of bacterial attachment sites showed the involvement of limited areas of PMN membrane surf... | 338,617 | [
-0.07929992,
0.05331348,
0.03936011,
0.2552148,
-0.2241277,
-0.1709923,
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0.3687423,
-0.08981737,
0.2890145,
-0.06546465,
-0.2791141,
-0.4160094,
-0.0002994006,
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-0.4473107,
-0.008346216,
0.2944386,
0.2035212,
0.3956518,
0.2888996,
-0.015... |
Evaluation of two rapid methods for identification of commonly encountered nonfermenting or oxidase-positive, Gram-negative rods. | The ability of the expanded API-20E and the Oxi-Ferm System to identify 176 isolates of nonfermenting or oxidase-positive, gram-negative rods from 17 species or groups was studied. The expanded API-20E, without referral to a computer reference center, was able to identify 61.4% of the isolates to the species level. If ... | 338,626 | [
-0.05137749,
0.3589619,
0.1269381,
0.1344996,
-0.1895845,
-0.02054931,
0.02018677,
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-0.6120395,
0.05219184,
0.1600628,
0.0290419,
0.1704088,
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-0.7171248,
0.3858482,
-0.001582088,
-0.3223547,
0.1366527,
0.1974991,
0.1498619,
... |
IgA localisation in glomerular diseases. | The structural changes found on light and electron microscopy study of 25 renal biopsy specimens that showed significant glomerular IgA deposition on immunofluorescence were correlated with relevant clinical data. The morphology of a wide range of glomerulopathies seeen included mesangial proliferative (60%), membranou... | 338,632 | [
0.238378,
0.2168531,
-0.01268303,
-0.09213377,
0.07868676,
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-0.119058,
-0.2299897,
-0.04330304,
0.2244369,
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0.03871288,
-0.1072486,
0.01574887,
-0.195232,
0.006812982,
0.2318275,
0.2431535,
0.0451692,
0.2233617,
0.112255,
-0.1168719,
0... |
Isolation, lactoperoxidase catalyzed radioiodination, and recovery of proteins bound to insoluble immunoadsorbents. | A method for the direct radioiodination and recovery of proteins specifically absorbed to an insoluble immunoadsorbent is described. The optimal conditions for adsorption, washing, radiolabelling by lactoperoxidase catalyzed iodination, and elution of radiolabelled proteins from the immunoadsorbent have been determined... | 338,833 | [
-0.1560821,
-0.3085305,
-0.09150386,
-0.03463464,
0.03729152,
-0.1529453,
-0.1955415,
0.1828268,
0.09067231,
0.1682218,
0.08790755,
-0.06184513,
0.06394438,
0.008823168,
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0.08790997,
-0.4395908,
-0.04328874,
-0.05924679,
0.3694222,
0.2346303,
0.1498604,
-0.2064... |
Hepatitis B antigen and polymyositis. | Concomitant polymyositis diagnosed by muscle biopsy developed in a 51-year-old man with hepatitis B surface antigen (HBsAg) hepatitis. Findings from immunofluorescent studies showed deposits of gamma-globulins and complement in both muscle and liver. The HBsAg and HBsAg-antibody complexes were detected in the liver by ... | 338,934 | [
-0.1143089,
-0.1131417,
-0.1666582,
0.1913947,
-0.02480702,
-0.0270184,
-0.2621095,
0.06540913,
-0.04827493,
0.08149827,
0.05832966,
0.1828073,
0.16141,
0.2240198,
-0.2386612,
-0.1553447,
-0.3188633,
-0.00277805,
-0.0926493,
0.05339698,
0.1375298,
-0.005341834,
-0.0385218... |
[Immunologic HLA-typing. A tool for selection of recipients in transplantation and for detection of disposition to certain diseases (author's transl)]. | Some decades ago, animal experiments have shown that inbred mice with completely identical genetic characteristics accept transplants between each other without any problem while transplants between individuals of genetically different strains are being rejected after a few days. It was also proven later that with men,... | 338,972 | [
0.02100219,
-0.2718317,
0.1454249,
0.01268174,
0.3189355,
-0.2899035,
0.005130492,
0.1374951,
0.1587609,
0.07584175,
0.1112306,
-0.1006184,
0.4125251,
-0.2191461,
-0.5993935,
-0.2909687,
-0.2676143,
0.03504647,
-0.2521984,
0.1261234,
0.09845506,
0.1906935,
-0.1777593,
-... |
Clinical trial with rifampicin in the treatment of leprosy (final report). | A controlled trial of Rifampicin plus Dapsone had been in progress for two years in the Department of Leprology, School of Tropical Medicine, Calcutta. Interim results of this trial after six months treatment were reported in 1976. The present paper is the final report of the study after two years of treatment. The stu... | 338,983 | [
-0.2215461,
0.05804216,
0.2114497,
-0.1285097,
-0.003828472,
-0.3690117,
-0.2892722,
-0.001358067,
0.08622269,
-0.1548516,
0.1391443,
0.1236554,
0.07894951,
0.2823751,
-0.553493,
-0.1878004,
-0.2990774,
0.07931513,
-0.1067585,
0.257845,
0.0711568,
0.08192768,
-0.05125668,... |
Chemical and immunological studies of cell surfaces from normal and transformed cells. | Immunological and chemical studies of cell surfaces from normal and transformed BALB/c fibroblasts have shown alterations associated with transformation. The cells studied include normal lines which do not cause tumors when injected into BALB/c mice, viral transformants, and spontaneous transformants which cause tumors... | 338,994 | [
-0.04026502,
-0.4228679,
-0.2687683,
-0.006674586,
0.2288759,
-0.02090986,
0.1046336,
0.1367005,
0.1362254,
0.3232293,
0.08440851,
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-0.03284616,
0.1015309,
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0.1399462,
-0.2055911,
-0.02927921,
0.2463338,
0.2172676,
-0.1580453,
0.1566605,
-0.4420292,... |
Autogenic biofeedback treatment for migraine. | Autogenic biofeedback training appears to be a promising technique for the treatment of migraine headaches, as reflected in the literature reviewed herein and in the data from 21 patients who were followed up for an average of 10 months. Autogenic biogeedback training exemplifies an important trend in psychosomatic med... | 339,010 | [
-0.4846812,
0.3087257,
-0.1779974,
0.1106149,
0.06525382,
-0.4985624,
-0.04816577,
-0.1385015,
0.08758946,
-0.200095,
0.117461,
0.03135065,
-0.05517469,
-0.5492784,
-0.4511673,
0.1133809,
-0.1469103,
0.1713926,
-0.3963209,
0.01446109,
-0.04322028,
0.2941478,
-0.3320197,
... |
The thirty degree transposition flap. | The rhomboid and other 60 degrees transposition flaps have theoretical and practical disadvantages for many applications. A better flap for these is one having an angulation of 30 degrees at its distal end. When this 30 degrees flap is combined with the M-plasty, a versatile and cosmetically favorable repair is provide... | 339,020 | [
-0.2306623,
-0.007831054,
-0.1108794,
-0.4262868,
-0.06550497,
0.004442695,
-0.03041403,
-0.1623728,
0.2719294,
0.194827,
0.1309597,
-0.2731532,
-0.2386062,
0.1763121,
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0.07761256,
-0.09459724,
-0.2041994,
-0.0718227,
0.2276726,
0.1011806,
-0.0419132... |
Spontaneous mutability in UV-sensitive excision-defective strains of Saccharomyces. | The genes RAD1, RAD2, RAD3 and RAD4 encode enzymes in the pathway leading to excision repair of UV-induced DNA damage in Saccharomyces cerevisiae. Four mutant alleles of these loci (rad1-1, rad2-2, rad3-12, and rad4-3) were studied for their effect on spontaneous reversion rate to lysine and histidine independence, by ... | 339,064 | [
0.1439574,
-0.6786485,
-0.1815735,
-0.1480367,
0.2337014,
-0.2341559,
0.02480418,
0.0151963,
0.402147,
0.2070949,
0.08603411,
0.2392755,
-0.1555473,
0.1236566,
-0.1486608,
0.194177,
-0.2767838,
-0.2094398,
0.1080346,
-0.1757752,
0.4686491,
0.4496541,
0.1498348,
0.124419... |
Cytogenetic findings in pernicious anaemia. Comparison between results obtained with chromosome studies and the micronucleus test. | To elucidate whether the micronucleus test may be a sensitive test for the demonstration of the occurrence of spontaneous structural chromosomal aberrations in human disease, bone-marrow smears and chromosome preparations were studied from ten patients with pernicious anaemia. An increased incidence of metaphases with ... | 339,066 | [
-0.03339047,
0.04724832,
-0.002266168,
0.03081678,
-0.009536198,
-0.0888988,
-0.05181777,
0.01291004,
0.08551029,
0.07774214,
0.1079738,
0.1841004,
-0.003730748,
0.2141874,
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-0.1927591,
0.1481508,
-0.2465234,
0.106802,
0.3477641,
0.1155196,
0.1156082... |
[Echography in the diagnosis of kidney diseases]. | Nephrosonography has become a useful diagnostic tool in assessing renal disease. Parenchymal structure can be viewed by stable B-scan or A-scan and, even better, on the grey scale. The principles of applying ultrasounds and for examining results are described together with percutaneous renal punction and nephrostomy gu... | 339,131 | [
-0.2211352,
0.07876413,
-0.02056956,
0.01247712,
0.163426,
-0.2434547,
-0.2437882,
-0.290793,
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0.0881643,
0.03957509,
-0.2488961,
-0.1896176,
-0.07380247,
-0.493561,
-0.4391232,
-0.5269331,
0.04375952,
0.3636364,
-0.2809887,
0.3324498,
0.05452931,
-0.3412552,
... |
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