title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Use of lyophilized homologous spongy bone in tibial head fractures]. | 30 comminutive fractures of the tibial head which all needed bone grafting beside the internal fixation of the fracture, have been investigated, autogenic material having been used 19 times, allogenic 11 times. The results of the grafting, controlled 1 1/2 to 7 years later, are in both groups absolutely identical. Free... | 350,812 | [
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Murein biosynthesis during a synchromous cell cycle of Escherichia coli B. | The last stages of murein biosynthesis were studied in relation to the division cycle of Escherichia coli in cells synchronized by amino acid starvation (Ron et al., J. Bacteriol. 123:374--376, 1975). Murein synthesis and the activities of the D-alanine carboxypeptidase and transpeptidase were found to vary significant... | 350,823 | [
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Lipoprotein from Proteus mirabilis. | The biosynthesis of a Proteus mirabilis outer membrane protein of molecular weight of approximately 7,000 was found to be relatively resistant to puromycin and rifampin, as is the case for the Escherichia coli liporotein. Furthermore, the existence of the lipoprotein in P. mirabilis was indicated by a comparison of the... | 350,832 | [
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Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli: structure of F100, F152, and F8 and mapping of the Escherichia coli chromosomal region fep-supE-gal-attlambda-uvrB. | The genetic and physical structures of commonly used F-prime factors carrying the galactose region of the Escherichia coli chromosome were analyzed. Deletions in the chromosomal DNA sequences in the F-prime factors were found to be frequent events. A genetic method was developed to reconstruct the original F-prime fact... | 350,847 | [
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Cell-cell recognition in Saccharomyces cerevisiae: regulation of mating-specific adhesion. | Mating-specific adhesion between haploid yeast cells of opposite mating type (a and alpha) was studied by using a quantitative agar plate assay. Washed a and alpha cells that had not previously been exposed to their respective opposite mating type ("naive" cells) adhered relatively weakly. In water, only 5 to 10% of th... | 350,854 | [
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Solubilization and partial purification of yeast chitin synthetase. Confirmation of the zymogenic nature of the enzyme. | Chitin synthetase was solubilized with digitonin from a particulate yeast fraction. The solubilized enzyme, which did not sediment at 200,000 X g and emerged after the void volume in a Sepharose 6B column, was active only after treatment with a protease. This confirms that chitin synthetase exists in the plasma membran... | 350,873 | [
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Structure of cortical microtubule arrays in plant cells. | Serial sectioning was used to track the position and measure the lengths of cortical microtubules in glutaraldehyde-osmium tetroxide-fixed root tip cells. Microtubules lying against the longitudinal walls during interphase, those overlying developing xylem thickenings, and those in pre-prophase bands are oriented circu... | 350,889 | [
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Sporozoites of rodent and simian malaria, purified by anion exchangers, retain their immunogenicity and infectivity. | Sporozoites of rodent malaria, Plasmodium berghei, and simian malaria, Plasmodium knowlesi and Plasmodium cynomolgi, were partially separated from mosquito debris and microbial contaminants by passage of Anopheles material through a DEAE-cellulose column. In addition to eliminating most of the contaminants (80-90%), th... | 351,177 | [
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Role of sulfate conjugation in estrogen metabolism and activity. | There has been an increasing interest in the sulfate conjugates of estrogens as important metabolites in steroid hormone homeostasis and activity. In women estrogen sulfates have been known as major components of plasma originating from ovarian secretion and hepatic metabolism. However, only recently has the capacity t... | 351,200 | [
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Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VII. Mortality and selected nonfatal events with insulin treatment. | The University Group Diabetes Program is a long-term prospective clinical trial designed to evaluate the effects of various hypoglycemic agents on vascular complications in patients with asymptomatic adult-onset diabetes. Mortality and blood glucose levels were determined as well as certain nonfatal events for patients... | 351,218 | [
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Legionnaires' disease in Vermont, May to October 1977. | Thirty-two confirmed and 24 highly probable cases of Legionnaires' disease occurred in Vermont between May 1 and Oct 15, 1977. Confirmed cases had positive results for direct fluorescent antibody testing of lung tissue or fourfold rise in antibody titer. Highly probable cases had one elevated titer (greater than or equ... | 351,219 | [
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[Heliomycin decrease in the pool of purine- and pyrimidine-containing compounds in bacterial cells]. | Heliomycin inhibited formation of the pool or purine and pyrimidine containing compounds in the cells of the growing cultures of Staphylococcus aureus and Escherichia coli both in the lag phase at the maximum rate of formation of the pool of compounds absorbing at 260 nm and in the exponential phase. A decrease in the ... | 351,337 | [
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The interaction between ethanol and antihistamines. 1: Dexchlorpheniramine. | Thirteen paid student volunteers (9 male, 4 female) were used in a double-blind crossover experiment to investigate the effects of a therapeutic dose of dexchlorpheniramine alone, and in combination with a social dose of ethanol on perceptual, cognitive and motor functions. Both ethanol (0.75 g/kg) and dexchlorpheniram... | 351,355 | [
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Cultivation of malarial parasites. | The method for continuous cultivation of Plasmodium falciparum has now been successfully applied to several strains from different geographical areas. It has been used for tests of antimalarial drugs, for studies of parasite-host cell interactions with special reference to sickle haemoglobin, and for the production of ... | 351,412 | [
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Toward drugs derived from cannabis. | Recent work aimed at the introduction of natural and synthetic cannabinoids as drugs is reviewed. Delta1-Tetrahydrocannabinol (delta1-THC) is mainly investigated as a potential drug against glaucoma and asthma, and as an antiemetic agent in cancer chemotherapy. Cannabidiol is being tried in the clinic against epilepsy ... | 351,429 | [
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Prophylactic use of cefazolin in monitored obstetric patients undergoing cesarean section. | Prophylactic cefazolin was evaluated in high-risk obstetric patients who had invasive fetal monitoring and subsequent cesarean section. A three-dose regimen of either cefazolin or placebo was administered randomly in a double-blind manner to 93 patients, 48 receiving cefazolin and 45 placebo, with the first dose given ... | 351,488 | [
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[Importance of the viability of the endothelium of corneal grafts]. | Since we use a very strict control of the viability of the endothelium of the graft, we have no more failures in corneal grafting not even in cases with bad prognoses, such as Fuchs' endothelial dystrophy. On the contrary, in corneal grafting without this control, we had failures in 20% of the cases. | 351,500 | [
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Gonioscopy: uses old and new. The inheritance of occludable angles. | The goniolens has become increasingly important in the practice of ophthalmology, For example, the treatment of angle closure and neovascular glaucoma is most effective in the earliest stages of the diseases, even prior to the onset of symptoms. Routine gonioscopy is essential if patients are to be provided optimum car... | 351,502 | [
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Haemoflagellates: commercially available liquid media for rapid cultivation. | The successful cultivation of a variety of haemoflagellates in three different liquid media is reported. These media include medium 199, Grace's insect tissue-culture medium and Schneider's drosophila medium, each in combination with 30% (v/v) foetal calf serum. These media were used to cultivate Old and New World spec... | 351,527 | [
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Immunological reactions caused by infection with Mycobacterium paratuberculosis. A review. | The natural resistance of cattle to infection with Mycobacterium paratuberculsis in relation to their immunological reactions is recorded. In vivo and in vitro manifestations of cell-mediated immunity during infection are reviewed, together with the antibody responses. It is suggested that three distinct immunological ... | 351,550 | [
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The interconversion of conformers of phenylalanyl-tRNA with different affinity to 70S ribosomes of Escherichia coli. | Earlier the existence of two conformers of Phe-tRNAPhe of E. coli was demonstrated because one of them yields complexes with 70S-poly(U) of extremely high affinity and the other with at least a 105 lower binding constant. We denote the first conformer as HAC (high affinity conformer) and the second as LAC (low affinity... | 351,562 | [
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Calcium requirements in man: a critical review. | Many official bodies give advice on desirable intakes of calcium but no clear evidence of a calcium deficiency disease in otherwise normal people has ever been given. In Western countries the usual calcium intake is of the order of 800-1000 mg/day; in many developing countries figures of 300-500 mg/day are found. There... | 351,589 | [
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[Clincial aspects and treatment of exacerbated chronic respiratory insufficiency in silicosis patients]. | The clinical picture and treatment of exacerbated chronic respiratory insufficiency is studied in 189 silicosis patients with different stage and degree of decompensation. It is found out that chronic respiratory insufficiency determination in these patients is conditioned by the exacerbation of a chronic inflammtory p... | 351,609 | [
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[Treatment of blood circulation disorders with a hemoactive-vasoactive drug]. | The therapeutic activity of Fludilat in circulatory disorders was evaluated in 9 women and 11 men, with ages between 41 and 75 years. Three suffered atherosclerosis and 17 diabetic vascular disease. Elimination of the symptom was obtained in intermittent claudication in 71 per cent of the patients who suffered it, in 6... | 351,601 | [
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Medico-psychological interventions in male asthmatic children: an evaluation of physiological change. | The purpose of this study was systematically to evaluate the effectiveness of several modes of psychological intervention used with male asthmatic children being treated in the Allergy Outpatient Clinic. Therapeutic effectiveness was measured by large airway changes in respiratory function, and the number of recurrent ... | 351,664 | [
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[Comparison of radioimmunologic and immunoenzymatic methods in detection of Australia antigen]. | A new immunoenzymatic method (enz-me-linked-immunosorbent-assay) has been compared with the radioimmunologic method, in solid-phase, for the research of HBsAg in serum analysed in normal routine. This method has evidenced a high sensitivity and correlation to the RIA test. | 351,695 | [
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Characterization of the normoblast population in beta-thalassaemic blood by rapid-flow cytofluorometry. | Samples of peripheral blood from patients with beta-thalassaemia major which contained significant numbers of nucleated normoblasts were stained with acridine orange and analyzed with rapid-flow cytofluorometry. The pyknotic normoblast-nuclei gave less green 'DNA' fluorescence than the (diploid) leucocytes and constitu... | 351,792 | [
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[Effect of group B vitamins on 35S-lipoic acid intake by mouse tissues]. | Lipoic acid intake following parenteral administration with functionally linked vitamins depends on molar relations between them. It is shown that a combined administration of 35S-lipoate with these vitamins decreases radioactivity 30-120 min after the injection in most of tissues as compared to the control, except for... | 351,901 | [
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0.05752769,
-0.005720678,
0.5257228,
0.5206923,
0.3500663,
0.023735... |
[On the regulatory role of amino acids in biosynthesis and formation of protein structure]. | There exist definite relations between certain amino acids in the process of protein biosynthesis. Interactivation in their incorporation into synthesizing proteins is observed between ones and interinhibition between others. The mentioned phenomena are observed in studies both at the model experiments on the enzymic s... | 351,902 | [
-0.2065735,
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0.004038483,
0.2471788,
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0.1122527,
0.2760419,
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0.2919041,
0.06531645,
0.1972175,
-0.228125,
... |
Lesions of Cowper's ducts and glands in infants and children. | Lesions of Cowper's duct and gland are more common than previously reported. They may be asymptomatic or may cause micturition difficulties or urinary retention. They may be congenital or acquired (usually inflammatory). Radiographic findings are either a rounded filling defect arising from the floor of the bulbous ure... | 351,914 | [
-0.1986326,
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0.1809337,
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0.4001187,
-0.06956843,
-0.0628901... |
[The diagnostic scope of ultrasonography in renal pathology (author's transl)]. | The accuracy of ultrasonography in the diagnosis of different pathological renal conditions is evaluated. Correlations were established to the findings on intravenous urography and selective angiography. Ultrasonography is suitable for the determination of the exact size and site of the kidney and, therefore, should be... | 351,972 | [
-0.0260771,
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0.06879596,
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0.216304,
0.3562629,
0.003961422,
0.1521832,
-0.006933347,
-0.0606426,
... |
Levamisole in multiple sclerosis; with special reference to immunological parameters. A pilot study. | Nineteen patients with multiple sclerosis (MS) have been given one course of levamisole therapy, and 16 patients two courses of levamisole treatment in daily dosages of 100--150 mg over two periods lasting from 1 month to 22 weeks each. Clinical effect was evaluated using Kurtzke's disability status scale. Immediate cl... | 352,087 | [
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0.1417494,
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0.4145052,
0.05208901,
0.3190797,
0.1595682,
-... |
Clinical use of non-invasive method for determining oxygen saturation: ear oximetry. | Oxygen saturation can be estimated by measuring the absorption properties of the arterialized blood perfusing the ear. Simultaneous determination of oxygen saturation by blood gas and ear oximetry showed no statistical difference. This non-invasive method allows rapid and accurate monitoring of the oxygenation status o... | 352,202 | [
-0.1301299,
0.05867851,
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0.05128041,
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0.1363798,
-0.550036,
0.01188081,
0.1048806,
-0.1380667,
0.1103254... |
Comparative physiological effects of incorporated amino acid analogs in Escherichia coli. | The relative toxicities of several incorporated analogs of phenylalanine, methionine, arginine, and proline were assessed by a variety of criteria in a derivative of Escherichia coli 15 requiring the antagonized amino acids. Toxicity of the analog-substituted cell protein was most consistently indicated by its insolubi... | 352,262 | [
-0.09832688,
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0.08029486,
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0.00907697,
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-0.09491412,
0.5115271,
0.3579903,
0.5613874,
-0.04... |
Incidence of anatomical variants in renal vasculature in the presence of normal renal function. | This report defines the incidence of variations in the renal vascular pedicle in a group of patients with normal renal function as determined by standard laboratory criteria. The study group consisted of 166 patients undergoing renal arteriography as potential renal allograft donors. Ninety-seven patients were male and... | 352,280 | [
-0.3165096,
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0.00538612,
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0.2659629,
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0.300344,
0.3088626,
-0.3554609,
... |
A longitudinal study of the mechanisms of action of debrisoquine and propranolol. | 1 The mode of action of hypotensive drugs is not necessarily the same early and late in a course of treatment. 2 It was aimed to study this possible difference of effects for the drugs debrisoquine and propranolol, using a clinical trial design and measuring as many cardiovascular functions as possible by noninvasive m... | 352,376 | [
-0.1783697,
0.1044472,
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0.08838098,
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0.07042176,
0.2139304,
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0.01148343,
0.02353906,
0.3652489,
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-0.002055117,
-0.2385677,
0.3381941,
-0.1365152,
-0.03616966,
-0.14944... |
Sterelogical analyses of leukaemic cells. | With the development of different treatment schedules for acute and chronic leukaemias it has become essential that a uniform, standardized classification of malignant cell type is achieved. Without a standardized diagnosis it is impossible to compare the results of differing treatment regimes. Present diagnosis is sti... | 352,386 | [
0.237349,
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0.03517308,
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0.4964583,
0.5455303,
0.1673832,
0.1206916,
0.0241868... |
Kinetic studies on the inactivation of Escherichia coli RTEM beta-lactamase by clavulanic acid. | The kinetic details of the irreversible inactivation of the Escherichia coli RTEM beta-lactamase by clavulanic acid have been elucidated. Clavulanate is destroyed by the enzyme and simultaneously inhibits it by producing two catalytically inactive forms. One of these is transiently stable and decomposes to free enzyme ... | 352,394 | [
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0.4351718,
0.3547898,
0.6003931,
-0.0401461,
-0.03953166,
... |
Chemical studies on the inactivation of Escherichia coli RTEM beta-lactamase by clavulanic acid. | Incubation of clavulanic acid with the beta-lactamase from Escherichia coli RTEM leads to enzyme-catalyzed depletion of clavulanic acid, to transient inhibition, and to irreversible inactivation of the enzyme. Both the transiently inhibited and the irreversibly inactivated species show a marked increase in the absorban... | 352,395 | [
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0.1176524,
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0.1162567,
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0.3285415,
0.2154763,
0.4228477,
0.08816621,
0.02260175,
... |
Phospholipid biosynthesis and secretion by a cell line (A549) which resembles type II aleveolar epithelial cells. | The A549 cell line is a continuous cell line derived from a human adenocarcinoma of the lung. At low cell population density the cells contain relatively few lamellar bodies, but in mature cells in very confluent cultures lamellar bodies are abundant. The lamellar bodies from these cells are enriched for phosphatidylch... | 352,403 | [
-0.2336076,
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0.1592175,
0.1528991,
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0.03751561,
0.0455029,
0.5026504,
0.1847536,
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0.1... |
A mutant of Escherichia coli which accumulates large amounts of coproporphyrin. | A mutant of Escherichia coli which accumulates a large amount of coproporphyrin, presumably because of a block in heme biosynthesis, has been isolated after nitrosoguanidine mutagenesis. On rich media, the mutant forms colonies which give bright orange fluorescence when illuminated with ultraviolet light. The mutant ap... | 352,406 | [
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0.06406188,
0.05560258,
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0.312691,
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0.2303557,
0.1703988,
0.2957247,
-0.01703818,
-0.1282699,... |
Evolution of ethylene by Saccharomyces cerevisiae as influenced by the carbon source for growth and the presence of air. | Effects of the carbon source and oxygen on ethylene production by the yeast Saccharomyces cerevisiae have been studied. The amounts of ethylene evolved by the yeast culture were less than those detected in the blank (an equal volume of uninoculated medium), suggesting a net absorption of ethylene by the yeast cells. Ad... | 352,497 | [
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0.02445481,
0.3582789,
0.1291659,
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0.03142169,
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0.3137898,
0.08042975,
0.00153711... |
Detection of Mycoplasma hominis and Mycoplasma orale in cell cultures by immunofluorescence. | Mycoplasma contaminants of animal and human cell cultures were rapidly detected and identified by an indirect immunofluorescent technique. Cells suspected of being contaminated by mycoplasmas were grown as monolayers on chamber slides in a culture medium selected to promote mycoplasmal growth. Before fixation by aceton... | 352,499 | [
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0.3055632,
0.01247949,
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0.1589336,
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0.3250327,
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0.1894776,
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0.2007343,
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0.3100428,
-0.04911919,
0.01171005,
... |
B lymphocyte differentiation in lethally irradiated and reconstituted mice. A histological study using immunofluorescent detection of B lymphocytes. | The recovery of the B lymphocyte compartments was investigated in lethally irradiated mice reconstituted with fetal liver cells. This was done by means of immunofluorescence on frozen sections of spleen, lymph nodes and Peyer's patches. The first B lymphocyte recovery in the spleen was observed on day 8, a few days ear... | 352,529 | [
0.1047499,
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0.1280943,
0.1784151,
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0.3650123,
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0.04851665,
0.5270832,
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0.5662093,
0.4010724,
0.2191352,
0.02326022,
-0.1... |
Cell surface markers for distinguishing different types of rat dorsal root ganglion cells in culture. | The distribution of three cell surface markers on dissociated cultures of the rat dorsal root ganglion has been investigated using indirect immunofluorescence. Tetanus toxin binds to a nondividing class of cells with neuronal morphology. Ran-1 is expressed by Schwann cells. Thy-1 is expressed both by fibroblasts and by... | 352,534 | [
0.128226,
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0.06896364,
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0.1882427,
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0.2347008,
0.1850944,
0.04250908,
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0.1480265,
-0.04057315,
... |
Hypothalamo-pituitary-gonadal function in male central precocious puberty. | Eleven boys aged 1-10 years with central precocious puberty were studied. According to the pubertal development six were classified as P2, one as P3 and four as P5. In all cases plasma testosterone levels were definitely elevated (1.7-5.8 ng/ml) when compared with pre-pubertal controls. Peak values after HCG (3 X 1500 ... | 352,578 | [
0.187479,
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0.1947103,
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0.2223385,
0.2410454,
0.1122245,
-0... |
Localization of luteinizing hormone-releasing factor in the human placenta. | Luteinizing hormone-releasing factor (LRF) has been found to be produced by the placenta. In the present study, the localization of this releasing factor was delineated by the use of an immunofluorescnece technique. Intense fluorescence was localized in the cytotrophoblast, along the outer surface layer of the syncytio... | 352,732 | [
0.3642201,
-0.2234734,
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0.163591,
0.1734237,
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0.2520992,
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0.322317,
0.2356871,
0.03843518,
... |
Protective effect of rabbit immune serum administered orally to rats infected by a human pathogenic strain of E. coli. | 1-week-old rats were inoculated orally with a strain of E. coli (serotype 078) isolated from the blood of a newborn baby who had died of septicemia. During the 3 weeks following inoculation, approximately 50% of the animals died of septicemia and 60% of the surviving rats had pathogenic bacteria in their rectum. Some o... | 352,764 | [
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0.02414456,
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0.2840379,
0.1724591,
0.450826,
-0.1546063,... |
Corticosteroid therapy of alcoholic hepatitis. | Fifty-five patients with alcoholic hepatitis were studied in a 28- to 32-day randomized double blind treatment trial comparing prednisolone (40 mg per day) with placebo therapy. Of 31 placebo-treated patients, 4 died during the study interval and 2 more died within 5 days of study completion. Only 1 of 24 prednisolone-... | 352,788 | [
0.1076843,
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0.1527531,
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0.4187082,
0.06697433,
0.05000021,
-0.2101165,
... |
Chromosomes in malignant lymphomas (study on short-term lymph node cultures). | In 15 cases, chromosome studies were performed in short-term lymph node cultures, using the banding technique. Clonal aberrations were found in two cases of Hodgkin's disease and in two of lymphosarcoma. In agreement with earlier observations, the cases of lymphosarcoma with abnormal karyotypes proved hyperdiploid. No ... | 352,853 | [
-0.2088755,
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0.01919993,
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0.03098806,
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0.6460703,
0.1635646,
0.01032728,
... |
Inhibition of macrophage phagocytic activity by group A streptococcal cell walls. | Group A streptococcal cell walls inhibited phagocytosis of polystyrene latex particles by rat peritoneal macrophages in vitro. This inhibition was not accompanied by a measurable loss of cell viability. Group D streptococcal cell walls were relatively ineffective in altering phagocytosis. The effectiveness of group A v... | 352,930 | [
0.0481262,
0.05610824,
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0.2508569,
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0.339344,
0.2487362,
0.3084434,
0.1176616,... |
Association of hemolysin production, hemagglutination of human erythrocytes, and virulence for chicken embryos of extraintestinal Escherichia coli isolates. | One hundred forty-two strains of Escherichia coli isolated from extraintestinal infections were examined for colicin V (ColV) and hemolysin (Hly) production. For comparison, 20 strains isolated from the feces of normal individuals and 12 enteropathogenic strains of E. coli were tested for these properties. Thirty-five ... | 352,937 | [
-0.1849848,
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0.0912246,
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0.3078747,
0.2856266,
-0.3297031,
0.036... |
Infectious agents in immunodeficient murine models: pathogenicity of Nocardia asteroides in congenitally athymic (nude) and hereditarily asplenic (Dh/+) mice. | Congenitally athymic (Nu/Nu), hereditarily asplenic (Dh/+), and littermate control mice were given intravenous injections of homogeneous cell suspensions of the virulent Nocardia asteroides GUH-2. Kill curve, 50% lethal dose, and kidney clearance data were obtained over a period of 3 months postinfection. N. asteroides... | 352,942 | [
-0.4950829,
-0.3603168,
-0.4672974,
-0.2083105,
0.4814402,
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-0.3235387,
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0.4446904,
0.346093,
0.4844497,
-0.2315672,
-0... |
Ideal target organism for quantitative bactericidal assays. | We have developed a target organism which permits quantitative bactericidal assays. The organism is an Escherichia coli mutant which cannot grow at the temperature of the assay (37 degrees C), but retains full colony-forming potential for subsequent quantitation at 25 degrees C. We show that quantitative data on the ba... | 352,943 | [
0.007770897,
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-0.2492884,
0.4457436,
0.2268789,
0.2957431,
0.1488683... |
Pathogenesis, lethality, and immunizing effect of experimental cutaneous cryptococcosis. | Mice were subcutaneously inoculated with small numbers of virulent Cryptococcus neoformans and divided into groups. Numbers of viable yeasts at the site were estimated at weekly intervals for 5 weeks on the basis of cultures of minced tissue excised from sacrificed animals. Organisms multiplied at the site for at least... | 352,944 | [
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0.2434072,
0.339759,
0.3779208,
0.0293,
... |
A double blind study with melperone and placebo in the treatment of chronic alcoholics. | In a 2-wk randomized double blind study 60 chronic alcoholics were treated with either melperone (Buronil) or placebo. The patients were assessed daily using a scale including 4 items: tension, depression, craving and sleep. Statistically significant improvement was achieved in the placebo group only for "tension" and ... | 352,974 | [
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0.2511252,
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0.3072044,
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0.2350969,
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0.1785194,
-0.0799149,
-0.2241081,
0.002734146,
... |
Methylergometrine: comparison of plasma concentrations and clinical response of two brands. | There were no significant differences between the two brands of methylergometrine (methylergonovine), Methergin and Myomergin, in the radioimmunologically measured serum concentrations nor in the AUC after an oral 0.250 mg dose determined on the third or sixth postpartum day during a continuous treatment with methylerg... | 352,975 | [
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-... |
Escherichia coli gene that controls sensitivity to alkylating agents. | A new type of Escherichia coli mutant which shows increased sensitivity to methyl methane sulfonate but not to UV light or to gamma rays was isolated after mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. The mutant is unable to reactivate phage lambdavir or double-stranded phiX174 DNA (replicative form) that had... | 353,028 | [
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... |
Site of inhibition of peptidoglycan biosynthesis during the stringent response in Escherichia coli. | The site of inhibition of peptidoglycan synthesis during the stringent response in Escherichia coli was determined in strains which were auxotrophic for both lysine and diaminopimelic acid (DAP). Cells were labeled with [(3)H]DAP for 30 to 60 min in the presence and absence of required amino acids, and the cellular dis... | 353,038 | [
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0... |
Characterization and incidence of pigment production by human clinical group B streptococci. | Pigment was produced in stab cultures by 97% of 297 group B streptococci isolated from human clinical specimens. The pigment, which was associated with a membranous cell fraction, showed a four-banded absorption spectrum similar to that of a carotenoid, with maxima at 435, 566, 485, and 525 nm. Addition of glucose to t... | 353,069 | [
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... |
Biotyping of Serratia marcescens and its use in epidemiological studies. | A Serratia marcescens biotyping system using eight carbon sources (benzoate, DL-carnitine, m-erythritol, 3-hydroxybenzoate, 4-hydroxybenzoate, lactose, D-quinate, and trigonelline), a tetrathionate reduction test, production of prodigiosin, and horse blood hemolysis was derived from a recent numerical taxonomic study (... | 353,073 | [
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0.3073179,
0.09122009,... |
Lysosomal enzyme cytochemistry of blood neutrophils. | Patients with bacterial infection may show altered membrane permeability of the primary azurophilic lysosomes of blood neutrophils. A new enzyme cytochemical technique, sensitive to increased membrane permeability caused by contact of neutrophils with acetone, saponin, low pH, Streptolysin O, bacteria, and nylon wool, ... | 353,080 | [
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A comparison of postsurgical healing following debridement by ultrasonic or hand instruments. | Subjects for the study were 15 patients requiring periodontal surgery in the maxillary posterior quadrants. A split mouth technique with assignment of quadrants by random alternation was used. Assessments were carried out at given time intervals using the Gingival Index, crevicular fluid measurement, Plaque Index and R... | 353,249 | [
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-0.4081741,
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0.003320811,
-0.0113074... |
A new class of antimalarial drugs: derivatives of benzothiopyrans. | A series of substituted benzothiopyrans was synthesized and examined for antimalarial activity. Some were found to be active and curative at dose levels of 160--360 mg/kg against Plasmodium berghei in mice. Afew observations concerning structure-activity relationships were made. The benzothiopyrans were prepared by tre... | 353,282 | [
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0.1475233,
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... |
Effect of RNase III on efficiency of translation of bacteriophage T7 lysozyme mRNA. | RNase III had no positive effect on the translation of bacteriophage T7 lysozyme mRNA in vivo or in vitro. The time of appearance and quanity of lysozyme in T7-infected E. coli BL107, an RNase III- strain, and T7-infected E. coli BL15, a nearly isogenic RNase III+ strain, were indistinguishable. Nearly identical patter... | 353,304 | [
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0.1149... |
Disulfiram implantation. A placebo-controlled trial with two-year follow-up. | Ten alcoholics implanted with disulfiram had longer periods of abstinence after treatment than did 10 alcoholics implanted with placebo; 7 of the disulfiram-implanted patients experienced a disulfiram-ethanol reaction in uncontrolled drinking situations, while none of the placebo-implanted patients did. | 353,387 | [
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... |
Mutations in the tryptophanyl-transfer ribonucleic acid ligase of E. coli causing temperature-sensitivity for growth. | Strains of Escherichia coli K-12 with altered tryptophanyl-tRNA ligases, conferring temperature-sensitivity for growth, have been isolated as spontaneous one-step mutants. The mutated enzymes differ markedly in activity from the wildtype, even at the permissive temperature. When assayed at the non-permissive temperatur... | 353,515 | [
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... |
Transposon-mediated insertion of R factor into bacterial chromosome. | Insertion of transposon T n1 into the E. coli JC411 chromosome results in a sharp increase of plasmid RP4 integration frequency. This effect is absent in JC1553 recA cells. The RP4 integration with the chromosome is probably accomplished via recA-dependent recombination between transposon Tn1 inserted into the chromoso... | 353,520 | [
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... |
Map position of the replication origin on the E. coli chromosome. | Strains carrying a dnaA temperature sensitive (t.s.) mutation and a Mu-1 prophage inserted within different genes near the origin of replication have been constructed. For each strain, integratively suppressed Hfrs, named G and D in which the ori region was replicated clockwise and counterclockwise respectively, were i... | 353,522 | [
-0.1081141,
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0.1043537,
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Microbiological mutagenicity studies of pesticides in vitro. | 14 pesticides were tested as pure compounds for the induction of point mutations in four strains of Salmonella typhimurium--TA1535, TA1536, TA1537 and TA1538--in the presence and in the absence of rat-liver microsomal fractions and for the induction of resistance to low concentrations of streptomycin in the filamentous... | 353,549 | [
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... |
Traumatic embolization of the intracranial internal carotid artery. | A 3 mm pellet, shot into the neck of a 13 year old boy, migrated into the common carotid artery and lodged in the infraclinoid internal carotid artery. The case illustrates an unusual intravascular migration of a foreign body. The benign clinical course, radiological evaluation, and rationale for expectant management o... | 353,583 | [
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... |
[Volume distribution studies on the platelet populations (author's transl)]. | The volume distribution into human platelet populations was investigated in order to determine if thereis a relationship between the cell density and the cell size and if the isolated platelets are homogeneous populations of cells. The platelet populations were isolated from platelet rich plasma or from washed platelet... | 353,656 | [
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... |
Treatment of status asthmaticus in children with high doses and conventional doses of methylprednisolone. | Twenty-one children who were admitted to the hospital with status asthmaticus were assigned randomly to one of two groups. Children in group A received methylprednisolone sodium succinate intravenously, 30 mg/sq m every six hours (conventional dose), and those in group B received methylprednisolone sodium succinate int... | 353,682 | [
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0.11864... |
[The treatment of abdominal evisceration using the wire technique (author's transl)]. | The insertion of wires in the preventive and curative treatment of abdominal evisceration is a variety of atraumatic open full-thickness sutures which are easy to carry out and particularly effective. In preventive treatment, they facilitate abdominal closure and avoid the risk of evisceration when large areas of skin ... | 353,704 | [
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0.4101947,
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Construction of recombinant plasmid carrying the lambda DNA fragment responsible for prophage integration. | The recombinant DNA molecules were constructed from plasmid RSF2124 and the EcoRI fragment of lambda DNA containing the genes responsible for prophage integration. The presence of these genes in recombinant plasmids was detected genetically. lambda int-gene was shown to be expressed in either orientation of insertion i... | 353,729 | [
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Analysis of the steady-state mechanism of the aminoacylation of tRNAPhe by phenylalanyl-tRNA synthetase from yeast. | The steady-state mechanism of the aminoacylation of tRNAPhe by the corresponding synthetase from yeast has been investigated in detail by kinetic experiments. It was found that there are two alternative mechanisms: one favoured at low tRNA concentrations and the other at high tRNA concentrations. ATP and Phe are bound ... | 353,737 | [
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Plasma renin activity following renal transplantation. | Plasma renin activity (PRA) was studied serially for up to 21 days following transplantation in thirteen patients receiving renal allografts. PRA was measured during fasting and recumvency and its relationship to renal function, diuretic administration, plasma sodium, allograft rejection and blood pressure was examined... | 353,767 | [
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... |
Norepinephrine, vasopressin, glucagon, and A23187 induce efflux of calcium from an exchangeable pool in isolated rat hepatocytes. | Isolated rat hepatocytes do not actively accumulate Ca(2+) during prolonged incubation in vitro; however, these cells do exhibit a limited exchange of intracellular with extracellular Ca(2+). The exchangeable pool represents about 2 nmol of Ca(2+) per mg of protein. In medium containing either a low (20 muM) or high (1... | 353,809 | [
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... |
Epidermolysis bullosa: current concepts and management of the advanced hand deformity. | A current classification of the types of epidermolysis bullosa is reviewed, in conjunction with some etiological concepts. The pathomechanics of the advanced hand deformity are discussed, and applied to a sequential plan of reconstructive surgery. The objective is the restoration of elementary hand function. Two illust... | 353,849 | [
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0.02402... |
[Child psychiatry through the years]. | A brief survey of the development of pedopsychiatry in the first half of this century shows how the emphasis changed from an initial interest in handicapped children to an interest especially in environmental and social factors. An attempt is made to explain this change in pedopsychiatric thinking, consideration being ... | 353,859 | [
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[Development of nosological conceptions of child psychoses]. | A study of the historical development of nosological conceptions of schizophrenia of children in parallel with the development of pedopsychiatry shows that these conceptions closely follow the lines of adult psychiatry. The description of psychosis-like conditions such as infantile dementia and autism also did not yet ... | 353,860 | [
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... |
Helen Flanders Dunbar (1902-1959) and a holistic approach to psychosomatic problems. II. The role of Dunbar's nonmedical background. | Despite Dunbar's central role in the American psychosomatic movement, few successors seem to have grasped the nature and context of her work. This is partially because, as conveyed in Part I of his article, most histories of psychosomatic theory and research overlook the holistic, organismic point of view shared by Dun... | 353,863 | [
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The morphological basis of the glomerular permeability to proteins. | The morphological basis of the glomerular permeability to proteins is reviewed and a survey is given of the studies done with ultrastructural tracer substances. In the normal GCW two structures have been considered important as a possible barrier to macromolecules: the GBM and the epithelial slit pore and slit diaphrag... | 353,959 | [
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[Long-term experience in endosseous endodontic implantation]. | The results of 9 years experience with transfixed abutment-teeth for bar-joint dentures in the lower jaw were collected. The method has been slightly altered since the beginning, and these changes are described in order to complete earlier publications: there are special chapters dealing with the implant-material Synta... | 353,976 | [
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0.004732684,
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-0.3775978,
0.2063824,
-0.03401293,
-0.3071237,
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-0.3725142,
0.1078577,
-0.05681752,
0.2941318,
0.4503726,
0.1499169,
0.3841394,
... |
Levamisole and the treatment of Herpesvirus hominis infections. A case report. | The successful treatment with levamisole of 3 categories of Herpesvirus hominis infection is described. A fourth category of patients infected with vulval condylomata acuminata were unsuccessfully treated with levamisole. The dosage regimen is discussed. The most dramatic feature was the relief of the severe pain encou... | 354,039 | [
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0.0108313,
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0.1584117,
0.03643659,
0.09610384,
0.01714267,
0.06111016... |
Antibody-coated bacteria in urine of patients with ileal conduit urinary diversion. | The antibody-coated bacteria (ACB) test is a helpful adjunct for differentiating pyelonephritis from cystitis in the intact urinary tract, particularly in female patients. This test was used in patients with ileal conduits and infected urine in an attempt to determine whether bacilluria was of renal or conduit origin. ... | 354,159 | [
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0.1072504,
0.3077719,
-0.09504682,
... |
Pills for the poor: John Wesley's Primitive Physick. | While John Wesley's Primitive Physick (1747) cannot be termed a classic of British medical literature, it must certainly be identified as one of the most popular volumes published in England during the eighteenth century. Although the work came under attack from contemporary surgeons, physicians, and apothecaries, who ... | 354,225 | [
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0.2805451,
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[Surgery for hypospadias using a penile and scrotal skin flap]. | It is reported on a penoscrotal operation method, where the penile urethra is formed by a skin stripe of penis and scrotum. 35 cases operated by means of this method, the operation technique of which is described in detail, operated cases had altogether good functional and cosmetic results with a completely complicatio... | 354,266 | [
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0.4892984,
0.1282323,
0.1177197... |
[Biochemical and serological characteristics of Escherichia belonging to the serological group 01]. | A circulation at the territory of the country of various biochemical and serological variants of escherichia belonging to serological group O1, isolated in acute intestinal diseases of children and adults, was revealed. Nonhomogeneousness of the partial composition of the O-antigen was demonstrated; K-antigens were det... | 354,288 | [
-0.1087439,
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0.1519515,
0.1031205,
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... |
[Immunoglobulin and antibody content in the blood serum, coprofiltrate and saliva of patients with Sonne dysentery]. | The authors studied the immunoglobulin and specific antibodies content of various classes in the serum, coprofiltrates and the saliva of 68 patients suffering from Sonne dysentery and in 48 healthy adult persons. Mancini's test demonstrated a significant elevation of IgG and IgM content in the blood of dysentery patien... | 354,289 | [
0.118111,
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0.3438337,
0.1365989,
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-0.1643479,
0.109... |
Specificity of gastric proteinases. | The aim of our study was to isolate the gastricsin fraction in the purest possible form and to verify some of its properties for further study of the specificity of synthetic substrates. The next step in our research will be a similar analysis of pepsin. | 354,358 | [
-0.1123706,
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0.1313224,
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0.3280038,
0.2314528,
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0... |
Glutathione reductase deficiency in a kindred with hereditary spherocytosis. | A kindred with hereditary spherocytosis was found to have erythrocyte glutathione reductase deficiency. The glutathione reductase was evaluated enzymatically and immunologically. The enzyme activity could not be restored either by flavin adenine dinucleotide (FAD) in vitro, or by oral administration of FAD. Kinetic and... | 354,376 | [
-0.2569562,
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0.2728813,
0.2284416,
0.1465598,
-0.05802433,... |
Alternative procedures for identification of anaerobic bacteria. | Recognizing the need for practical inexpensive procedures which allow identification of anaerobes commonly encountered in clinical laboratories, a number of investigators have in recent years proposed various alternatives to the expensive, time-consuming techniques presently recommended by reference anaerobe laboratori... | 354,382 | [
-0.087978,
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0.07099047,
0.04336598,
-0.03436464,... |
Field evaluation of primaquine in the control of Plasmodium vivax. | Two regimens of primaquine in combination with amodiaquine have been compared with amodiaquine alone in known cases of Plasmodium vivax in an endemic area of El Salvador, C.A. A 5-day regimen of primaquine, with dosages based on an adult dose of 15 mg per day, produced a substantial reduction in the numbers of patients... | 354,416 | [
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0.2891251,
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0.3253196,
0.07873891,
0.0004544406,
0.125... |
Pathogenesis of respiratory syncytial virus infection in ferret and fetal human tracheas in organ culture. | The pathogenesis of human respiratory syncytial virus infection was studied in ferret and fetal human tracheas in organ culture. Although the patterns of virus growth were similar in these species, the sites and morphologic consequences of virus replication differed markedly. In human trachea, synthesis of respiratory ... | 354,444 | [
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-0.1184788,
0.08737358,
0.2941237,
-0.3027... |
Cofactor role of iodide in peroxidase antimicrobial action against Escherichia coli. | The mechanism of antimicrobial activity of the peroxidase-hydrogen peroxide (H(2)O(2))-iodide (I(-)) system was investigated. Inhibition of respiration and loss of viability of Escherichia coli were used as measures of antimicrobial activity. Because the bacteria destroyed H(2)O(2), peroxidase antimicrobial action depe... | 354,514 | [
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0.294618,
0.05039969,
0.2832737,
... |
Comparison of the toxicities of patulin and patulin adducts formed with cysteine. | The toxicities of patulin and of the patulin adducts formed with cysteine were compared using the mutation-sensitive strain Escherichia coli W3110 thy polA1 and its polA1+ revertant. The acute toxicities of patulin and of the adduct mixture were also compared using NMRI mice. The adduct mixture was shown by thin-layer ... | 354,524 | [
-0.2836628,
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-0.211958,
0.07911076,
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0.1444299,
0.4702919,
0.0298525,
0.2783228,
0.2817875,
-0.41... |
Detection of mutagens produced by fungi with the Salmonella typhimurium assay. | Forty-one fungal isolates (one isolate per species) representing common plant pathogens and food crop contaminants were grown on sterile, polished rice and assayed for mutagenic activity in the Salmonella typhimurium-microsome system. Initially, single doses of aqueous and chloroform extracts of the moldy rice were ass... | 354,528 | [
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0.2161741,
0.01584348,
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0.3276689,
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0.1035192,
0.4007684,
0.3355106,
0.2446742,
0.424... |
Indocyanine green: a new vital stain for use before penetrating keratoplasty. | Indocyanine green selectively stains devitalized corneal endothelial cells. In addition, the dye has been found to be nontoxic to the function of living endothelial cells. Indocyanine green appears to be an ideal vital stain for use before penetrating keratoplasty. | 354,616 | [
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0.01222771,
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0.01831391,
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0.06737134,
... |
Protecting chicks and poults from Salmonellae by oral administration of "normal" gut microflora. | Resistance of young chicks and poults to salmonella exposure was substantially increased by early oral administration of intestinal contents or feces from selected adult chickens. Protection was secured also by administering anaerobic broth cultures of intestinal microflora from selected donor birds. Protection, was su... | 354,629 | [
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0.03743679,
-0.2423707,
0.4212359,
0.01051542,
0.19811,
0.04108225,
... |
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