title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Phosphorus and the eutrophication of lakes--a personal view. | The availability and abundance of biologically-active forms of phosphorus in natural waters are briefly reviewed in relation to the requirements, growth and development of algal populations. The consequences of artificial enrichment of lakes with agricultural, domestic and industrial effluents ('eutrophication') attrib... | 357,120 | [
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The dissipation of phosphorus in sewage and sewage effluents. | Of the 41 kt of phosphorus reaching the sewage works in England and Wales 15 kt is removed in sewage sludge and the remainder is disposed of to rivers. 60% of the sewage sludge is now used as fertilizer and this proportion will no doubt increase in the future. The total use of sewage sludge, however, represents only ab... | 357,121 | [
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Modern mankind's influence on the natural cycles of phosphorus. | When the molten surface of the earth solidified over 4 X 10(9) years ago the quantity of phosphorus to be contained in the storehouse of the new planet had already been resolved. The phosphorus was locked in an igneous lithosphere as orthophosphate. With the advent of the first primitive rainstorms the slow endless pro... | 357,125 | [
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Transcutaneous PO2 measurement for evaluating the oxygen supply of skin allo- and autografts. Theory and practical application. | The condition of skin autografts and allografts in rats and rabbits was checked by transcutaneous PO2 measurement according to R. HUCH, D. W. LUBBERS and A. HUCH. The tcPO2 values obtained with standardized maximal hyperemia allow conclusions concerning the oxygen supply and thus the vascularization of a transplant. Th... | 357,153 | [
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Splenic transposition with ligation of the vascular pedicle in rodents. Immunological consequences. | By splenic subcutaneous transposition and ligation of the vascular pedicle, the direct relation spleen-liver was interrupted in rodents infected with malaria. It was demonstrated that in this situation detoxification of the liver and recovery from malaria was evidently hampered by the lack of a direct splenic cell supp... | 357,154 | [
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Ontogeny of B lymphocyte function. VI. Ontogeny of thymus cell capacity to facilitate the functional maturation of B lymphocytes. | The differentiation of the B cell population from fetal mice to produce a normal, adult-like, heterogeneous reponse, with respect to antibody affinity, has been shown to require (or to be facilitated by) thymus cells. The maturation of the thymus cell population to be capable of facilitating this differentiation of the... | 357,163 | [
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Pulmonary metabolism of epoxides. | Activities of epoxide hydrase (EH) and glutathione S-transferase (GST) have been measured in pulmonary tissue from several species. On the basis of total organ activity, pulmonary tissue has less capacity than liver tissue to metabolize epoxides. Pulmonary EH and GST appear to be refractory to induction by typical agen... | 357,180 | [
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The intermediate-sized filaments in rat kangaroo PtK2 cells. II. Structure and composition of isolated filaments. | When cultured cells of the rat kangaroo cell line PtK2 grown on plastic or glass surfaces are lysed and extracted with combinations of low and high salt buffers and the non-ionic detergent Triton X-100 cytoskeletal preparations are obtained that show an enrichment of 6 to 11 nm thick filaments. The arrays of these fila... | 357,225 | [
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A double-blind crossover evaluation of ketoprofen (Orudis) and placebo in rheumatoid arthritis with assessment of long-term tolerance. | A two-week double-blind crossover study of ketoprofen, a non-steroidal antiinflammatory agent, and placebo was done in ten patients with active rheumatoid arthritis in order to obtain a preliminary efficacy estimate of this new drug. Even after only one week of treatment, joint activity was significantly reduced while ... | 357,231 | [
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[The nasal cavity and paranasal sinuses of the red deer (Cervus elaphus)--anatomical corrosion studies]. | By means of thirty skulls of dominating female animals the formation and topography of the Cavum nasi and its Sinus paranasales of the red-deer are described. The main results are on the one hand the total absence of a Sinus frontalis and a Sinus sphenoidalis and on the other hand the characteristic formation of the Si... | 357,242 | [
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Isolation of the regulatory segment of the biotin operons of Escherichia coli K-12. | A DNA fragment of 463 base pairs has been isolated by HpaII digestion of the EcoRI cleaved lambdabiot124-10 DNA fragment containing the Escherichia coli biotin gene cluster. This HpaII subfragment contains the biotin regulator region. The biotin regulator DNA has been characterized by electron microscopic heteroduplex ... | 357,250 | [
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Comparative immunological analysis of host plasma proteins bound to bloodstream forms of Trypanosoma brucei subspecies. | The presence, location, host specificity, identity, and quantity of rat plasma proteins bound to bloodstream forms of Trypanosoma brucei subsp. brucei, T. brucei subsp. rhodesiense, and T. brucei subsp. gambiense were determined by a quantitative indirect fluorescent-antibody method and gel immunoassays. Fluorescence d... | 357,291 | [
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Cefazolin and cephradine: relationship between serum concentrations and tissue contents in mice. | The relationship between serum concentrations and tissue levels of various doses of cefazolin and cephradine was determined in experimentally infected mice. An infection was induced by injection of 5 X 10(6) Escherichia coli into the right hind leg, antibiotics were administered 1 h later. At 15-minute intervals mice w... | 357,295 | [
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The principles of controlled clinical trials of drugs. | The principles of evaluation of new drugs are described and discussed. This evaluation is carried out in three consecutive phases. The first one is performed on young, healthy volunteers. The general response to the drug and signs of toxicity are registered. Preliminary data about absorption, elimination and metabolism... | 357,309 | [
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Methodological aspects of clinical evaluation of antianginal drugs. | The principles of patient selection and designing and management of the clinical evaluation of antianginal agents are discussed. The study should involve patients with stable angina pectoris, history of anginal attacks of at least three months duration with five or more attacks per week, ST-segment depression at least ... | 357,310 | [
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Bacterial catabolism of lipoic acid. Isolation and identification of a methyl ketone. | A soil bacterium, Pseudomonas putida LP, can be grown on lipoate as sole source of carbon, sulfur, and energy. In addition to the previously identified catabolites (bisnorlipoate, tetranorlipoate, beta-hydroxybisnorlipoate, lipoate thiolsulfinate, and two bisnorlipoate thiolsulfinates) isolated from cultures of the org... | 357,321 | [
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Factorial relationships of measures of perceived level of psychopathology and sociometric choice. | Studied the relationship of diagnosis, age, length of hospitalization, and various measures of perceived level of psychopathology, perceived appropriateness of hospitalization, and sociometric choice among 39 adolescent psychiatric inpatients. Factor analysis revealed two factors, one that was apparently a measure of p... | 357,452 | [
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Mobilization of the Proteus mirabilis chromosome by R plasmid R772. | The P-1 incompatibility group plasmid R772 can mobilize the chromosome of Proteus mirabilis strain PM5006. The decreasing gradient of recombinant recovery frequencies found for markers which were increasingly distal to 0 min with plasmid D donors was not found with R772. Instead, it produced recombinants for all marker... | 357,678 | [
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Combined endodontic and restorative treatment considerations. | Endodontic treatment for pulpal pathology should result in an asymptomatic tooth with a sealed canal. Restorative treatment for the pulpless tooth should provide protection against fracture and the needed resistance against masticatory stress to allow the tooth to resume normal function. | 357,709 | [
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The psychological training of Abraham Flexner, the reformer of medical education. | The great reformer of American medical education was Abraham Flexner. His basic emphasis was to insist that medical education should be solidly based on science. Not a physician, Flexner's specialized training was in psychology. This paper traces the major influence on Flexner's thinking (primarily the works of Hall, S... | 357,713 | [
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A reevaluation of B-lymphocyte levels in peripheral blood from cancer patients. | B-lymphocytes were quantitated in mononuclear cell suspensions derived from the peripheral blood of patients with various nonlymphoreticular cancers. The method used was anti-IgM and anti-IgD membrane immunofluorescence. The mean percentage of circulating B-lymphocytes in 78 cancer patients tested was 5.3 +/- 4.6 with ... | 357,747 | [
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Primary splenic tuberculosis in transplant candidates. | Caseous granulomatous lesions, consistent with tuberculosis, were found in the spleen in two of our renal transplant candidates. There was no clinical evidence of tuberculosis in either patient. Only one patient had a positive tuberculin skin test whose chest film showed hilar calcifications suggestive of healed granul... | 357,750 | [
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Longterm treatment with brompheniramine and phenylpropanolamine in recurrent otitis media--a double-blind study. | A double-blind study has been performed in 44 children with recurrent episodes of otitis media and/or secretory otitis media using a combined preparation of brompheniraminemaleate and phenylpropanolaminehydrocloride (Lunerin mite). No significant prophylactic effect was found on symptoms of respiratory tract infections... | 357,754 | [
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Furosemide compared with hydrochlorothiazide. Long-term treatment of hypertension. | In a double-blind crossover study, the effectiveness of furosemide, 40 mg twice daily, was compared with hydrochlorothiazide, 50 mg twice daily, in hypertensive patients. Both hydrochlorothiazide and furosemide significantly reduced blood pressure (BP) during three months of therapy. However, the fall in BP was consist... | 357,764 | [
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Liver transplantation. | From March 1963 through June 1976, 111 patients received orthotopic liver homografts. Forty-two of the recipients had congenital biliary atresia. Other common diagnoses were chronic aggressive hepatitis, Laennec's cirrhosis, and primary hepatic malignancy. There were also other assorted, less common diagnoses. Thirty-o... | 357,795 | [
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[Hereditary benign intra-epithelial dyskeratosis (Witkop--Von Sallman syndrome)]. | A case of inherited intraepithelial benign dyskeratosis (Witkop-Von Sallmann syndrome) is presented by the authors. The diagnosis is based on clinical and histological peculiarities. | 357,858 | [
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[Angiomas of the mouth]. | A patient with palatal hemangioma was subjected to study and the general characteristics of buccal hemangioma are analyzed. Their infrequent occurrence being remarkable. Maxillar angiomas have a reserved prognosis not only because of their histologic malignancy but also because of the threat of incoercible hemorrhage w... | 357,863 | [
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Elevated levels of pancreatic polypeptide in obese-hyperglycemic mice. | The concentration and distribution of pancreatic polypeptide (PP) was studied in hyperglycemic obese (ob/ob) mice and homozygous (+/+) controls. By radioimmunoassay, the concentration of PP in the pancreas of ob/ob mice was greater both in the duodenal lobe (70.7%) and in the body and tail (66.3%) when compared to iden... | 357,891 | [
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0.1247746,
-0.05436559,
-0.4... |
Systems to support clinical decisions: automated medical signal analysis. | The benefits and capabilities of an automated medical signal analysis system that can lead to more effective patient care are identified, the capabilities of different types of systems are briefly mentioned, and automated systems that support nominative and managerial decisions are described. The need for the practicin... | 357,940 | [
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0.014... |
Determination of radiation equivalence of ethyl methanesulphonate (EMS) for induction of gene conversion in diploid yeast. | A unit Rad-Equivalent Chemical (REC) has been suggested for purposes of quantitating the mutagenic hazards of chemicals. The usefulness of this approach is demonstrated by the establishment of a constant relationship between the forward mutation frequency and haploid genome size in various organisms for both radiation ... | 357,960 | [
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Immunoglobulin classes of human serum antibodies in vaginal candidiasis. | The titre and immunoglobulin class of antibodies against Candida albicans in serum from 60 non-pregnant women was determined. IgG titres up to 1 : 32, IgA titres up to 1 : 8, and IgM titres up to 1 : 4 were detected in 30 women with vaginal candidiasis. Similar titres were found in 20 women harbouring yeasts in the mou... | 357,978 | [
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-0.034... |
Fibronectins--adhesive glycoproteins of cell surface and blood. | A recently characterised class of adhesive, high molecular weight glycoproteins is present on the surfaces of cells, in connective tissue matrices, and in extracellular fluids. These proteins may have important roles in cellular adhesion, malignant transformation, reticuloendothelial system function, and embryonic diff... | 357,987 | [
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Bacteriophages inhibit degradation of abnormal proteins in E. coli. | On infection of Escherichia coli cells by bacteriophages T4, T5 or T7, the degradation of E. coli protein fragments and abnormal proteins is inhibited. Normal E. coli proteins, however, continue to be degraded at their usual rates. T4 early proteins (s) is needed to inhibit the turnover of abnormal proteins in T4-infec... | 357,993 | [
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0.... |
Lungs as a generator of prostacyclin--hypothesis on physiological significance. | In vivo anti-platelet de-aggregatory activity of exogenous prostacyclin is enhanced after its passage through the pulmonary circulation of anaesthetized cats, probably because of a concomitant generation of endogenous prostacyclin by the lungs. Evidence is also presented that perfused lungs of guinea pigs and rats spon... | 357,998 | [
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... |
Osmotic stimulation of pepsin secretion in the rat. | The effect of the osmolarity of intragastric instillates on pepsin secretion was studied in rats anaesthetised with urethane. Irrigation of the stomach with solutions of sucrose and NaCl, resp. caused a concentration-dependent increase in pepsin output. A stimulation was observed already by hypotonic solutions and the ... | 357,999 | [
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0.01597... |
Relationships between portions of the third and fourth ventricles. An aid to stereotactic accuracy for posterior fossa stereotaxy. | The relationships between the third and fourth ventricles have been studied by examination of the angles formed by third and fourth ventricular projections. These have been subjected to statistical analysis and have proved useful for posterior fossa stereotactic surgery. | 358,010 | [
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0.0504621... |
Effect of valproic acid on hepatic function. | Altered hepatic function tests occurred in four of 25 patients treated with valproic acid. An average dose reduction in three patients of 10 mg per kilogram per day resulted in reversion of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) to normal. The drug was discontinued... | 358,014 | [
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0.03466449,
... |
On the role of protein S4 N-terminal residues 1 through 30 in 30S ribosome function. | 30S ribosomal protein S4 contains a single cysteine residue at position 31. We have selectively cleaved the peptide bond adjacent to this residue using the reagent 2-nitro-5-thiocyanobenzoic acid. The two resultant fragments were purified. The smaller S4-fragment (1-30) was found to be incapable of interacting with 16S... | 358,148 | [
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Fluorescent localization of membrane sites in glycerinated chicken skeletal muscle fibers and the relationship of these sites to the protein composition of the Z disc. | Didansyl derivatives of amino acids and N-phenyl-1-naphthylamine were used to localize membrane hydrophobic sites in glycerol-extracted chicken skeletal muscle fibers. Epifluorescence microscopy revealed that such sites coincide with the distribution of mitochondria, the transverse tubular (T) system and the sarcoplasm... | 358,193 | [
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THe hazards of injecting local anesthetic solutions with epinephrine into flaps: experimental study. | In a study using paired longitudinal flaps on the back of the rat, we found evidence to support the findings of previous investigators regarding the toxic effects of injecting local anesthetic solutions containing epinephrine into delayed flaps. Epinephrine concentrations of 1:200,000 and 1:400,000 were demonstrated to... | 358,228 | [
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0.133980... |
Choosing the correct Limberg flap. | A technique is presented for designing the 8 possible Limberg flaps to close any given rhomboidal defect. Then we show how to choose out of those 8 the only two that will be correctly oriented so the donor area of the Limberg flap can be closed with a minimal amount of tension. | 358,233 | [
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0.1519564,... |
The effect of prostacyclin on the human umbilical artery. | Prostacyclin was tested on human umbilical artery obtained after spontaneous delivery or by Cesarean section. Isometric and isotonic responses were measured on spiral preparations in Krebs-bicarbonate buffer at 37 degrees C equilibrated with 95% O2 and 5% CO2. Spiral artery strips, whether superfused or mounted in orga... | 358,293 | [
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0.2361051,
... |
Termination of second trimester pregnancy with intra-muscular administration of 16 phenoxy-omega-17,18,19,20 tetranor PGE2 methylsulfonylamide. | A new prostaglandin analogue, 16 phenoxy-omega-17,18,19,20 tetranor PGE2 methylsulfonylamide was used for the termination of second trimester pregnancy in 60 patients. The drug was injected intramuscularly in doses of 0.5 mg 4 hourly, 1 mg 8 hourly or 1 mg 6 hourly for a maximum of 36 hours. Fifty five patients aborted... | 358,296 | [
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0.1256402,
0.600666,
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0.21... |
Acute cholecystitis treated by early and delayed surgery. A controlled clinical trial. | 100 patients with acute cholecystitis (AC) diagnosed by clinical, laboratory, and roentgenological examinations were randomly divided into 2 groups; early surgery (ES), operated within 7 days after the onset of acute symptoms, and delayed (DS), operated 2--3 months after the acute episode. Patients with elevated serum ... | 358,366 | [
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The use of dimethyl-sulfoxide (DMSO) in the treatment of interstitial cystitis. | Dimethyl-sulfoxide (DMSO) was used in 17 patients with interstitial cystitis. The diagnosis was made on the basis of clinical and laboratory findings and the characteristic picture with Hunner ulcera. The majority of the patients had responded poorly to other forms of conservative treatment. Subjective symptoms were co... | 358,382 | [
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[The operation on and death of Lieutenant M.J. Nix]. | One of the four Dutch military attaches who sided with the Republican forces in the Second Anglo-Boer War, Lieutenant M.J. Nix, was severely wounded during the battle at Sannaspost on 31 March 1900. A British shrapnel bullet injured his spine, which left him almost completely paralysed. He was transported in a Britis... | 358,425 | [
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... |
The precision and comparative sensitivity of interferon assays. | Any interferon assay essentially measures the potency of unknown samples relative to each other or to a standard. The reliability of such measurements of relative potency, i.e. the precision of the assay, is a key feature of any method. In contrast, sensitivity is seldom a characteristic of great importance in an assay... | 358,442 | [
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... |
Use of bacteriophage nucleic acid inducers of interferon in man. | The interest in therapeutic exploration of phage ds-RNAs is motivated by their antiviral and immunoregulatory activities. Preliminary studies in man indicate that topical application of native ds-RNAs represents no health-hazard to patients and may be beneficial in the therapy of viral skin and eye diseases. | 358,474 | [
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[New aspects in operative flail chest management (author's transl)]. | A method for stabilization of flail chest is described. A row of pericostal chromic catgut sutures is placed from the pleural surface using a probe as ligature carrier. | 358,492 | [
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Complementary structures of membrane fracture faces obtained by ultrahigh vacuum freeze-fracturing at -196 degrees C and digital image processing. | Conventional freeze-etch replicas of the cytoplasmic fracture face (PF) of the yeast plasmalemma membrane show hexagonally ordered regions. Complementary features on the extraplasmic face (EF) could not be identified. Replicas with improved topographical resolution were obtained for both fracture faces by ultrahigh vac... | 358,525 | [
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0... |
Sandwich enzymoimmunoassay of hepatitis B surface antigen (HBsAg). | A sandwich enzymoimmunoassay (EIA) procedure was developed for the detection of HBsAg using Fab' of anti-HBsAg conjugated with beta-D-galactosidase from Escherichia coli with anti-HBsAg-coated silicone rubber discs as a solid phase. EIA could detect 1 ng/ml of HBsAg. It was as sensitive as radioimmunoassay (RIA, AusRia... | 358,585 | [
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Cell-mediated immunity in professional and voluntary blood donors. | Cell-mediated immunity (CMI) was compared in professional and voluntary blood donors. Depressed CMI in professional donors was revealed by the presence of significantly lower numbers of positive delayed reactive hypersensitivity responses to Candida albicans, streptokinase and streptodornase, as well as a decrease in l... | 358,587 | [
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0.2516809,
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0.1779012,
-0.05605325... |
Reduction of trimethylamine N-oxide by Escherichia coli as anaerobic respiration. | E. coli was found to grow anaerobically on lactate in the presence of trimethylamine N-oxide (TMANO), reducing it to trimethylamine. Anaerobic growth on glucose was promoted in the presence of TMANO. When a culture grown in complex medium was transferred to defined medium, growth on glucose and ammonia took place in th... | 358,620 | [
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0.3931092,
0.1789791,... |
[The value of supportive therapy in the treatment of malignant tumors]. | Supportive care are a strongly connected constituent of the curative and palliative treatment of cancer. They serve for prevention and early diagnosis, respectively, and treatment of complications during therapy and disturbances which may issue from the tumour disease itself. These are especially the results of the ins... | 358,633 | [
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0.0227... |
[Variations in the use of microscopic instruments for the examination of urinary calculi in routine professional practice and in research]. | Generalising considerations concerning the problem of the analysis of urinary calculi as well as a longer testing within own examination prove modern microscopic methods and devices to be a scientific and practical instrumentarium for the examination of urinary calculi which has a good future. Expensive special microsc... | 358,660 | [
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0.318... |
[Immunogenic properties of various forms of flagellin]. | The authors obtained and studied immunologically flagellae of S. typhi and flagellins (monomeric and polymeric) obtained from them. Immunological activity of flagellin was the greater the higher the molecular weight of the preparation (the polymer molecules were the largest and the most immunogenic). There were reveale... | 358,692 | [
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0.002397417,
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... |
Prostaglandin-stimulated gastric mucus secretion in man. | In 6 healthy volunteers, following intragastric instillation of a prostaglandin analogue pentagastrinstimulated gastric secretion of acid, pepsin, and glycoprotein N-acetylneuraminic acid (NANA) was assessed. There was only a slight and statistically insignificant inhibition of acid output while pepsin secretion remain... | 358,722 | [
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0.02891315,
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Phagocytosis of 32P-labelled E. coli by human polymorphonuclear cells (PMN). Adaptation of a method. | A system for the study of phagocytosis by human polymorphonuclear cells (PMN) is presented. The leucocytes are harvested from heparinized whole blood by the Bøyum method and transferred to glass tubes to yield glass adherent monolayers of leucocytes, approximately 80% of which were PMN. A strain of E. coli labelled by ... | 358,745 | [
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0.2099382,
0.2698128,
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0.205454,
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Amipaque as contrast medium for intraosseous phlebography. | The degree of pain produced by Amipaque 260 and Isopaque 260 at intraosseous phlebography in patients with varicose ulcerations in the ankle region was compared. Amipaque produced less pain than Isopaque. No complications or side-effects occurred during the observation period of about one year. | 358,757 | [
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0.1793895... |
Choline acetyltransferase activity in rat heart after transplantation. | Choline acetyltransferase (CAT) catalyzes the biosynthesis of acetylcholine according to the chemical equation: Acetyl-CoA + Choline in equilibrium Acetylcholine + CoA. To demonstrate the neuronal relationship of this enzyme, CAT activity was measured in hearts to which the extrinsic innervation was completely interrup... | 358,843 | [
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... |
[Scanning and transmission electron microscopic studies of the development of the joint surfaces (author's transl)]. | The late embryonic and post partum development of the rat knee-joint has been studied by the transmission and scanning electron microscope. Undergoing a transformation in the sense of functional adaption to extrauterine life there is a final breakdown of the mesenchym cell layer (interzone) which separates in the embry... | 358,859 | [
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0.1479881,
0.02043013... |
[Intelligence : individual differences, genetic factors, environmental factors and interaction between the genotype and the environment (author's transl)]. | The authors undertook a review of published work on the sources of variation in individual differences in intelligence. They should : 1) that methods of quantitative genetics concerning intelligence are not applicable to human populations ; 2) that the results of studies on adoptions and on twins do not permit one to e... | 358,865 | [
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[Isolation of a cytolytic strain of hog cholera virus from IB-RS2 cells (author's transl)]. | An infectious agent, able to induce a definite cytopathic effect in pig kidney cell monolayers, was isolated from the IB-RS2 cell line. Immunofluorescence, seroneutralization and ultracentrifugation studies have permitted to identify this agent as hog cholera virus (HCV). Representative HCV-strains being devoid of path... | 358,888 | [
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... |
[2 types of auxotrophic mutants occurring by insertion of the ampicillin transposon into the chromosome of E. coli K-12]. | Insertion of transpozone TnI determining ampicillin resistance into the E. coli K-12 chromosome resulted in formation of auxothrophic mutants of 2 types. The mutants of the first type carried thermosensitive mutation resulting in auxotrophy with respect to isoleucine at a temperature of 43 degrees C. Such mutants occur... | 358,910 | [
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... |
Mode of incomplete cross-resistance among pipemidic, piromidic, and nalidixic acids. | Spontaneous mutants with various patterns of resistance to pipemidic acid (PPA), piromidic acid (PA), and nalidixic acid (NAL) were isolated from Escherichia coli K-12. Most mutants were less resistant to PPA than to PA and NAL, and some mutants resistant to PA and NAL were hypersusceptible to PPA. As for the mutants t... | 358,918 | [
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... |
Isolation of Klebsielleae from within living wood. | Previous studies from this laboratory have documented the presence of coliform bacteria emanating from wooden reservoirs containing finished drinking water. Coliforms were identified as Klebsiella pneumoniae and Enterobacter spp. In the present report, evidence is presented which suggests that the origin of these colif... | 358,920 | [
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Serology of amebiasis using the FIAX-TM system. | A new fluorescent immunoassay system (FIAX TM) has permitted development of a promising serologic test for amebiasis. The test is similar but far superior to the soluble antigen fluorescent antibody test. The main differences are the unique StiQ TM sampler and the flourometer itself. Quantitative results can be obtaine... | 358,934 | [
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Plasma-membrane lipid composition and ethanol tolerance in Saccharomyces cerevisiae. | Populations of cells suspended anaerobically in buffered (pH 4.5) M ethanol remained viable to a greater extent when their plasma membranes were enriched in linoleyl rather than oleyl residues irrespective of the nature of the sterol enrichment. However, populations with membranes enriched in ergosterol or stigmasterol... | 358,937 | [
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... |
Clinical and toxicological investigations of a case of delayed neuropathy in man after acute poisoning by an organophosphorus pesticide. | Progressive neuropathy developed in a man during 2--8 weeks after acute poisoning by a pesticide said to contain trichlorphon. The neuropathy was typical of that caused by organophosphorus esters in the delay and in the maintenance of normal conduction velocity in surviving nerve fibres. A sample alleged to be typical ... | 358,947 | [
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[Electron-microscopic and autoradiographic study of giant cells of foreign bodies in the focus of aseptic inflammation]. | Ultrastructure of sinuous proximal and straight distal tubules, as well as collecting tubules of the cortical layer in the rat kidney fixed with perfusion has been studied with electron microscopic morphometry 7--8 weeks after contralateral nephrectomy. The volume of mitochondria, the area of their crists, the area of ... | 358,949 | [
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The surface morphology of mitogen-stimulated human peripheral blood lymphocytes. | The changes occurring in surface morphology during the transformation of normal peripheral blood lymphocytes by phytohaemagglutinin (PHA) are described and the surface ultrastructure of the PHA-induced blasts is compared with that of pokeweed mitogen (PWM)-and rabbit anti-beta2-microglobulin antiserum-induced blasts. B... | 359,035 | [
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Studies of the effects of ultraviolet radiation on the structural integrities of ribosomal RNA components of the Escherichia coli 50S ribosomal subunit. | The effects of 254-nm radiation on the structural integrities of free and 50S ribosome-bound 5S and 23S ribosomal ribonucleic acids (rRNA) have been elucidated. Irradiation of aqueous solutions of Escherichia coli 50S ribosomes with 253.7-nm radiation results in the formation of single-strand breaks in double-stranded ... | 359,042 | [
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Positive end expiratory pressure: effects on lung mechanics of premature lambs. | Pulmonary mechanics were determined at 0, 3, 6, and 10 cm H2O positive and expiratory pressure (PEEP) in premature lambs at a mean gestational age of 134 days. Functional residual capacity increased (p less than 0.005) by 7% (1.6 ml/kg) per cm H2O PEEP. Dynamic lung compliance and specific compliance significantly decr... | 359,057 | [
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A double-blind study on the effects of butorphanol compared with morphine in balanced anaesthesia. | In a randomized double-blind trial a total of 50 consenting patients scheduled for elective surgical operations were given multiple intravenous doses of butorphanol tartrate or morphine sulphate in combination with other agents to evaluate and compare the efficacy of these drugs in balanced anaesthesia. Equipotent dose... | 359,108 | [
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A double-blind comparison of butorphanol and meperidine in labour: maternal pain relief and effect on the newborn. | Butorphanol tartrate 1 mg and 2 mg were compared in 80 normal mothers at term in a double-blind study with meperidine hydrochloride 40 mg and 80 mg for the relief of pain in labour. Butorphanol was found to be as effective as meperidine in relieving pain in labour. The foetal condition, as measured by ECG monitoring, A... | 359,109 | [
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Efficiency of bacterial filtration in various commercial air filters for hospital air conditioning. | Filtration efficiency of high-efficiency particulate air (HEPA) filters is said to be over 99.97% of removal rate against the mist of thermogenerating-type of dioctyl phthalate with average particles diameter of 0.3 micrometer, as tested by the U.S. Military Standard 282 (1956). Filtration of bacterial aerosols through... | 359,187 | [
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Non-equilibrium enzyme immunoassay of gentamicin. | We describe a fast, accurate non-equilibrium enzyme immunoassay for serum gentamicin. With use of isokinetic conditions an assay takes a total of 12 min, including regeneration of the immunosorbent. The coefficient of correlation between the present method and conventional microbiological assays was 0.98. | 359,194 | [
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-... |
Intra-renal factors in renin release. | Renin release is believed to depend more on vasodilatation in the afferent arteriole than on any other factor. This allows for opposing effects of vasoconstriction and vasodilatation produced by sympathetic nerve stimulation by drugs or by autoregulation, to be interpreted in relation to the study of stretch of the aff... | 359,238 | [
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Two trials of diflunisal in osteoarthritis. | Two double-blind inter-group trials were carried out in which diflunisal was compared for 12 weeks against aspirin in 30 patients with osteoarthritis of knees or hips, and against naproxen for 8 weeks in 20 patients with osteoarthritic knees. Diflunisal appeared to be somewhat better than aspirin in terms of both effec... | 359,252 | [
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Difunisal in general practice. | A large-scale, double-blind comparative study was carried out in general practice to assess the relative efficacy and tolerance of difunisal and aspirin in patients suffering from acute painful conditions such as sprains and trains, osteoarthritis, etc. Patients received either 250 mg or 500 mg difunisal twice daily, o... | 359,255 | [
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Care of the burn wound. | The initial therapy of thermal injuries is directed at removal of loose debris and necrotic epidermis, alleviation of pain, and prevention of infection. Following initial wound debridement, bacterial growth in the wound itself is controlled primarily through the use of tropical antibiotic agents and daily hydrotherapy ... | 359,257 | [
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0.3185014,
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-0.145991... |
Rationale for topical antibiotics. | Topical antibiotics are under attack by critics who claim that no proof of efficacy exists and that systemic administration is far more effective. In this paper, we review the existing evidence and conclude that topical antibiotics have a place in the prevention and treatment of superficial skin infections. Our own exp... | 359,258 | [
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Nuclear pores. Can they expand and contrast to regulate nucleocytoplasmic exchange? | Recent evidence has revived the idea that translocations of macromolecules between nucleus and cytoplasm may be regulated via expansion and contraction of the entire diameter of the nuclear pore complex. The present investigation does not support this hypothesis. | 359,342 | [
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Syngeneic transplantation of fetal rat pancreas. II. Effect of insulin treatment on the growth and differentiation of pancreatic implants fifteen days after transplantation. | Eight 18-days-postcoitum fetal pancreases were transplanted to isogenic alloxan-diabetic male rats. Some recipients were treated with insulin for seven days immediately after transplantation. Eight animals in both the insulin-treated group and control group were killed 15days after transplantation for morphologic and h... | 359,389 | [
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0.09579845,
-0.1462443,
-0.1402583,
0.2681063,
0.2860759,
0.2797228,
0.1628933,
-0.... |
Metabolism of ribosomal RNA in mutants of Escherichia coli doubly defective in ribonuclease III and the transcription termination factor rho. | To determine if proteins RNase III and rho, both of which can determine the 3' ends of RNA molecules, can complement each other, double mutants defective in these two factors were constructed. In all cases (four rho mutations tested) the double mutants were viable at lower temperatures, but were unable to grow at highe... | 359,408 | [
0.1622935,
0.03589988,
-0.0151875,
-0.1346685,
-0.1806056,
-0.1487352,
0.05305444,
0.06870717,
0.129253,
-0.02455601,
0.002924369,
0.074682,
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0.1051692,
-0.3284323,
-0.1888345,
-0.05069276,
-0.2515114,
0.08223916,
0.1045595,
0.6211402,
0.2641365,
-0.2183956,
... |
Influence of calcium, magnesium, lanthanum and A23187 on the aggregation of polymorphonuclear neutrophils. | Chemotactic factors transiently aggregate human polymorphonuclear neutrophils. We have found that the aggregation induced by the chemotactic tripeptide, formyl-methionyl-leucyl-phenylalanine, depends on the extracellular calcium and magnesium concentrations and is inhibited by 1 and 10 M lanthanum chloride. The ionopho... | 359,459 | [
-0.2566775,
-0.008083182,
-0.1801663,
-0.0705498,
0.238893,
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-0.06258275,
0.03958245,
-0.1962749,
0.1829953,
-0.2878219,
0.3623842,
0.1324676,
0.08887698,
-0.05835913,
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-0.1572882,
-0.08773623,
-0.0372576,
0.2201964,
0.1733957,
0.09993929,
0.0573485... |
Experimental nephropathy induced in the rabbit by immunization with a lipopolysaccharide from Escherichia coli. | Twenty rabbits were each injected with 100 microgram of lipopolysaccharide from Escherichia coli 055 at weekly intervals for up to 15 months. The antisera showed an immunologic cross-reactivity with rabbit kidney glycoprotein. A macroscopic nephropathy was present in 14 of the 17 rabbits in which the kidneys were exami... | 359,504 | [
0.06534763,
0.1117004,
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-0.00336971,
0.05649521,
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0.09663892,
0.1300569,
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0.2100632,
-0.08542404,
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-0.07198091,
0.001926325,
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-0.06330638,
-0.04701123,
0.03709988,
0.1310144,
0.4616281,
0.457523,
-0.1466... |
[The chemotherapy of urologic neoplasms]. | The newest aspects for the use of cytostatic agents in the treatment of bladder, prostatic and testicular carcinomas are presented. Especially the two new drugs diaminodichlor cisplatinum and adriamycin are discussed as to their potential use in these diseases. | 359,509 | [
-0.2332337,
-0.0745292,
0.02954969,
-0.1956185,
-0.01925146,
-0.2976857,
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0.1048292,
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0.3034209,
0.1536687,
0.3549805,
0.06435069,
-0.1196192,
-0.4253595,
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-0.2197216,
0.190256,
-0.06637353,
0.04204497,
0.4557314,
-0.02645411,
-0.1014855,... |
Immunization of calves against salmonellosis. | Salmonella typhimurium bacterins, containing adequate antigenic mass, protected calves against clinical signs of salmonellosis and death. Protection against salmonellosis was correspondingly reduced when the bacterin was diluted 1:10 and 1:100. A mouse protection test revealed that 17 of 18 (94%) of the S typhimurium-c... | 359,522 | [
-0.2500069,
-0.2382907,
-0.2474325,
-0.06239078,
0.03220596,
-0.1632651,
-0.2640073,
-0.2222857,
0.01866029,
-0.4363449,
0.03614347,
0.04719942,
-0.04011228,
0.229767,
-0.3561944,
-0.1689114,
-0.3392111,
0.06981072,
-0.01909702,
0.4116504,
0.197274,
0.1236716,
0.1678874,
... |
The bacteriophage lambda int gene product. A filter assay for genetic recombination, purification of int, and specific binding to DNA. | Bacteriophage lambda int gene is required for the integration of viral DNA into the chromosome of Escherichia coli. We have extensively purified the product of the int gene (Int) from a lysogen of E. coli that constitutively expresses this gene. Int was assayed by its ability to promote integrative recombination of sup... | 359,544 | [
-0.1455491,
0.136646,
-0.1919818,
0.1902414,
0.1079417,
-0.2422592,
-0.2601201,
0.0935249,
0.4933895,
-0.1700349,
-0.03056302,
0.00470225,
-0.0003032578,
-0.2281869,
-0.621084,
0.04394372,
-0.4277593,
-0.2323002,
-0.1206936,
0.3865881,
0.3237636,
0.0633696,
-0.2164975,
... |
Multiple forms of carboxypeptidase Y from Saccharomyces cerevisiae. Kinetic demonstration of effects of carbohydrate residues on the catalytic mechanism of a glycoenzyme. | In the course of our further investigation of the active site titration of carboxypeptidase Y, using 4-nitrophenyl trimethylacetate, we have found that carboxypeptidase Y can be isolated in different molecular forms. Carboxypeptidase Y obtained from Fleischmann baker's yeast has a molecular weight of 53,000, as compare... | 359,558 | [
-0.307393,
-0.3497952,
-0.3325275,
0.1407765,
0.453753,
-0.07145113,
0.103336,
0.1586045,
-0.03544213,
0.181659,
0.1905804,
-0.2399886,
-0.009083702,
0.004492221,
-0.437322,
0.04902989,
-0.4663245,
-0.02463173,
0.181504,
0.08557538,
0.1616618,
0.252629,
-0.06410919,
-0.... |
Subchondral route for nutrition to articular cartilage in the rabbit. Measurement of diffusion with hydrogen gas in vivo. | The route of nutrients going to articular cartilage was studied by determining the diffusion of hydrogen molecules from the subchondral circulation to the articular cartilage in rabbits. In all immature animals there was diffusion of hydrogen from subchondral bone into articular cartilage, while in the older immature a... | 359,565 | [
-0.1543978,
0.2022468,
-0.1215419,
-0.01025658,
-0.04436795,
-0.3124553,
-0.3139788,
0.137618,
-0.09748778,
-0.151359,
0.1497686,
-0.1168175,
0.001838783,
-0.3546693,
-0.2204226,
-0.1838515,
-0.1050136,
0.1650362,
-0.1050388,
0.06301117,
0.4149452,
0.1252505,
0.1155757,
... |
Histone localization in polytene chromosomes by immunofluorescence. | Polytene chromosomes of Chironomus thummi were treated with antisera elicited by purified calf thymus histone fractions, and the location of each histone type was visualized by the indirect immunofluorescence technique. Each of the antisera produced specific and distinct patterns of fluorescence, suggesting that it is ... | 359,571 | [
0.1974242,
-0.2088703,
0.03565516,
0.2014719,
-0.150279,
0.1258063,
0.007803129,
0.1990747,
0.1826455,
0.1993599,
0.08231919,
-0.1871297,
0.2492415,
-0.1460859,
-0.3079644,
-0.5148214,
-0.4496364,
0.07303847,
0.01010736,
0.02246966,
0.3635373,
0.1430607,
-0.2593337,
0.0... |
Determination of valproic acid (dipropylacetic acid) in plasma by gas-liquid chromatography. | A specific and sensitive procedure for the determination of valproic acid at therapeutic concentrations in human plasma has been developed. The method involves a microscale extraction of the drug from acidified plasma into chloroform. Caproic acid is added as internal standard. The extract is subsequently analysed on a... | 359,583 | [
-0.3229676,
0.1244868,
0.009175436,
-0.07368404,
0.3031389,
0.06022649,
-0.2441708,
0.1680541,
-0.06757434,
-0.02387014,
0.2271724,
-0.1212807,
0.1666682,
0.1739513,
-0.0743398,
0.08714655,
-0.3824514,
0.543351,
0.07744563,
0.09743796,
0.1695339,
0.0644844,
-0.01035295,
... |
Single-antigen immunofluorescence test for chlamydial antibodies. | A simple method is presented for producing large numbers of inclusions of Chlamydia trachomatis serotype L2 in cell cultures on slides for immunofluorescence antibody staining. Preliminary results with a total of 1,241 human sera from different groups were consistent with findings by earlier methods: 82% of chlamydia-p... | 359,585 | [
-0.03348029,
-0.03127476,
-0.1526252,
-0.08809114,
0.0317705,
-0.07649776,
-0.3371111,
0.1592404,
0.1924574,
-0.03946613,
0.1226512,
0.326288,
0.1959637,
0.3051053,
-0.4067102,
-0.264033,
0.01635239,
0.0263656,
-0.5258179,
0.1124697,
0.2215593,
0.1836763,
-0.01780242,
0... |
Split-thickness skin grafts: an experimental study of factors related to ease or difficulty of procuring satisfactory grafts of skin from man and some common laboratory animals. | Split-thickness grafts of skin of satisfactory quality were found to be more difficult to obtain from rabbits than from animals of other genera. An explanation for this was sought in the histology of the skins of the various experimental animals. Density of hair was judged to be the factor most critical for ease or dif... | 359,616 | [
0.4047496,
-0.2638949,
0.05159985,
0.19433,
0.2911171,
-0.3642915,
-0.1337284,
-0.0005591779,
0.03903165,
-0.1183863,
0.1162944,
-0.5787498,
0.1540103,
0.09810831,
-0.2644306,
0.1762292,
0.1816898,
0.03033167,
-0.1272211,
0.02528417,
0.03507017,
0.1278514,
-0.02166513,
... |
Induction of B cell priming by neonatal injection of mice with thymic-independent (type 2) antigens. | Mice injected at birth with the thymus-independent type 2 antigen TNP-AECM-Ficoll have augmented anti-TNP antibody responses when their spleen cells subsequently are challenged in vitro with TNP-coupled thymic independent or thymic dependent antigens. This neonatal priming effect was shown to occur in neonatal nu/nu mi... | 359,707 | [
-0.1328375,
-0.2458285,
-0.4338882,
0.03672276,
0.1644733,
-0.1439601,
-0.1608572,
0.1814632,
0.01826569,
0.3237539,
-0.05584726,
0.2768051,
0.1294952,
0.01156552,
-0.2614893,
-0.387917,
-0.260849,
-0.2404842,
-0.07623702,
-0.07077015,
0.4167043,
0.07674706,
-0.05218935,
... |
A sensitive haemolytic assay of mouse complement. | Under appropriate conditions the haemolytic activity of mouse complement can be measured in a 51Cr release assay. Modifications that increase the sensitivity are the following: (a) mouse 7 S anti-SRBC antibodies as amboceptor; (b) low amount of target cells; (c) ionic strength of 0.13 M NaCl in the test medium; (d) inc... | 359,711 | [
-0.28888,
-0.3199843,
-0.2934631,
-0.01379945,
-0.1591723,
0.04776797,
0.05374457,
0.03121263,
0.1098453,
-0.1865602,
-0.1097813,
0.3305556,
0.2743399,
-0.1037007,
-0.166492,
-0.3180582,
-0.5248437,
0.05751898,
-0.3484001,
0.4385809,
0.06315137,
0.09787732,
0.03174833,
... |
Detection of antisalivary duct antibody from Sjögren's syndrome by an autoradiographic method. | A new technique to detect anti-salivary duct antibody (ASDA) has been developed by using autoradiographic, rather than immunofluorescent methods. The antibody activity detected by autoradiography is probably classic ASDA. Both techniques may be consecutively performed on the same tissue section without attenuation of e... | 359,712 | [
0.04843298,
-0.238363,
-0.05710128,
-0.05869402,
-0.3417811,
0.1371439,
-0.2039645,
0.2127995,
0.2132894,
0.05416143,
0.08534759,
-0.005516083,
0.1388559,
-0.4195189,
-0.203741,
-0.2105446,
-0.5023707,
0.09364899,
-0.05591186,
0.02827542,
0.2130902,
-0.0507225,
-0.0703989... |
A fatal denture in the oesophagus. | An unusual case is described of a denture in the oesophagus which caused a fatal haemorrhage from the aorta. The post-mortem examination confirmed that a projection from the denture had impinged upon the aortic wall, after perforating the oesophagus, with subsequent erosion of the aorta. | 359,739 | [
-0.2303166,
0.1504821,
-0.1283244,
0.133277,
0.1041204,
-0.1863807,
0.004234557,
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-0.06540437,
0.1797636,
0.3008056,
0.2942318,
0.07193631,
-0.08579092,
0.01081669,
0.03476344,
-0.3907286,
0.09108574,
-0.1026245,
-0.245757,
0.2878171,
0.3292091,
0.05941024,
... |
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