title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Myocardial infarction without coronary artery changes]. | Since 1972 6 patients (4 males and 2 females) at the age from 18 to 44 years with myocardial infarctions could be observed whose coronary system in the subsequent coronarographic examinations proved to be unconspicuous. The diagnosis of the infarction was anamnestically, laboratory-chemically, electrocardiographically ... | 398,633 | [
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Microbiological examination of some Sudanese soils. | The composition of the microflora in different layers of four representative oil profiles of Sudan were studied. Counts of all types of microorganisms decreased significantly with depth in soil. Azotobacter, in particular, occurred in high densities; representative strains were isolated and studied for their different ... | 398,646 | [
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Domperidone (R 33 812) as an antiemetic in the treatment of postoperative vomiting. A double blind comparison between two different dosages (4 mg and 10 mg). | Forty seven patients received either 4 mg or 10 mg domperidone I.V. in a double blind study after they had vomited postoperatively. The patients were then observed for six hours. If necessary, the same dose of domperidone was repeated double blind but not during the first hour. When the two groups were compared there w... | 398,661 | [
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Effect of prostaglandins on hypothalamic-pituitary-testicular function in vitro. | The effect of prostaglandins (PG) A1, E1, E2 and F2 alpha in the concentration range of 10(-7)--10(-4) M were studied in vitro on a rat hypothalamic tissue, collagenase-digested isolated anterior pituitary cell and Leydig cell suspension system by measuring the testosterone production of incubated Leydig cells. PGs did... | 398,665 | [
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Studies on the derivatives of thiazole acetic acid. II. Syntheses and pharmacological analysis of 2-N-aralkylidene and 2-N-aralkyl derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. | A number of 2-N-aralkylidene, 2-N-aralkyl and 2-N-aralkyl-alpha-sulphoderivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid (I, R = H) and its methyl ester (I, R = CH3) were synthesized. As a result of condensation of methyl ester I with various aromatic aldehydes in boiling benzene solution, the Schiff-bases (... | 398,687 | [
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Methylation patterns of tRNA at different concentrations of dimethylsulphate. | The methylation patterns produced in E. coli B tRNA by various concentrations of dimethylsulphate were found to differ with a predominant formation of 7-methylguanine and 1-methyladenine at low concentrations and of a methylated compound not yet identified at high concentrations of methylating agent. The analysis by Sc... | 398,704 | [
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Use of tetramethylammonium hydroxide to determine the total fatty acid composition of microorganisms. | A destructive chromatographic method of identifying microorganisms is described. The method is based on hydrolysis of the biomass of the microorganisms in the presence of tetramethylammonium hydroxide, followed by introduction of the hydrolyzate into the heated injector of a gas chromatograph. The main products in this... | 398,717 | [
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Recent trends in research on occupational cervicobrachial disorder. | Recent rapid development of mechanization and automatization in many industries in Japan have increased simple and repetitive tasks that have resulted in some new types of occupational health hazards, in particular among young female workers. One of them is occupational cervicobrachial disorder, the concept of which wa... | 398,864 | [
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[Multiple minute digitate hyperkeratosis (a paraneoplastic system?)]. | A case of "Multiple Minuta and Digitata Hyperkeratosis" related to a carcinoma of the larynx is reported. The improvement of the cutaneous lesions after surgical treatment of the carcinoma suggests the possibility of considering this peculiar skin disorder as a paraneoplasic symptom. | 398,928 | [
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[Vogt-Koyanagi syndrome. Therapeutic trial with corticosteroid]. | A brazilian housewife, descendant of japanese (both parents), 37 years aged, affected with Vogt-Koyanagi's syndrome (uveitis, dysacousia, alopecia, madarosis, poliosis, vitiligo) was treated with prednisone. During the course and at the end of the treatment an almost complete regression of alopecia, poliosis, madarosis... | 398,933 | [
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Cardiorespiratory and metabolic patterns in multiple trauma patients. | During the last 3 years we have performed a detailed study in 50 patients using the Swan-Ganz catheter to provide prognostic haemodynamic and metabolic values at an early stage. There was a total of 320 severe injuries in these 50 patients with a statistical mean of six to seven. The severity of injuries is documented ... | 399,052 | [
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Comparison of captopril with propranolol in the treatment of mild and moderate essential hypertension. | Captopril (SQ 14,225), an angiotensin-converting enzyme inhibitor, was used in combination with propranolol, a beta-adrenergic blocking agent, in the treatment of mild and moderate hypertension. A significant decrease in blood presure was obtained (P less than 0.05). The maximum oral dose of captopril was 450 mg daily ... | 399,093 | [
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[Nature and significance of osteopenia]. | New realisations on the regulation of bone and calcium metabolism by hormones and vitamins, modern methods of the radiologic and morphologico-morphometric diagnostics considerably increased our knowledge about the deminerlising diseases of the skeletal system. The possibilities for diagnostics and therapy resulting fro... | 399,106 | [
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[Clinical aspects of myocarditis--symptomatology, diagnosis and pathogenesis]. | On the basis of newer knowledge from literature in a survey aspects of symptomatology, diagnostics and course of the myocarditis important for practice are represented. According to the frequency of the virus myocarditis is referred to the importance of immunopathogenetic factors for prognosis and course. Own experienc... | 399,108 | [
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[Treatment of tumor diseases in older people]. | By the increase of the average age of man among others also the problems of tumour diseases in old persons increasingly gain importance. In the therapy of malignant diseases, therefore, the various age-conditioned changes concerning the immunological system must be taken into consideration. Even though the tumour thera... | 399,110 | [
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Insulin receptors in human mononuclear leucocytes. I. Binding and degradation of insulin in normal subjects. | The binding and degradation of 125I-Insulin were investigated in mononuclear leukocytes of normal subjects. The binding data analysis show that the insulin degradation is strictly correlated with the binding of the hormone to its receptors: these data suggest that the binding of insulin to specific receptor is the poss... | 399,189 | [
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Study of the mutagenic action of cyclophosphane on bacteria in host-mediated assay. | The mutagenic actin of cyclophosphane (CP) on the bacterium S. typhimurium TA 1950 in host-mediated assay (mice) was investigated. The mutagenic effect of CP depended on the dose. Administration of carbon tetrachloride (CCl4) to the animals modified the level of the mutagenic effect of CP. The direction of the modifica... | 399,196 | [
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Perception of conspecific vocalizations by Japanese macaques. Evidence for selective attention and neural lateralization. | Japanese macaques (Macaca fuscata) and control species (vervet, pigtailed macaque, bonnet macaque) were trained for food to respond to one class of recorded fuscata vocalizations and do not respond to a second class. A measure of neural lateralization was obtained by presenting the stimuli randomly to the right or the ... | 399,204 | [
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[Goethe's own testimony about his involvement with "organic Nature." III. Letters (1818-1832)]. | This third and last extract from GOETHE's letters between 1818 and 1832 follows the Sophien-Ausgabe of Weimar with the exception of the last two remarks which were drawn from other sources. In 1818, GOETHE riched the 69th year of his life. In this late life-time, he corresponded with scientists, literati, musicians, hi... | 399,227 | [
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Is gestational diabetes an acquired condition? | Intrvenous injection of 30 mg of streptozotocin per kg body weight induces a mild diabetes in pregnant rats (first generation); the non-fasting blood glucose is increased and the percentage of endocrine tissue and also the percentage of granulated beta cells do not increase. The fetuses of these mildly diabetic pregnan... | 399,256 | [
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Influence of culture medium of the fatty-acid profile in enteric bacteria. | Enteric bacteria having a high content of cyclopropane fatty acids steeply increase their synthesis when grown on insufficiently propitious culture media (meat-peptone agar or modified Drobot'ko synthetic medium) as compared with bacteria grown under more favourable conditions (meat-peptone broth). Simultaneously, a de... | 399,287 | [
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Hormone therapy and affect. | This study investigated the influence of hormone therapy on affect in a double blind crossover trail. The sample consisted of 49 women who had previously undergone hysterectomy and bilateral oophorectomy. Therapy consisted of 3 mth each of ethynyl oestradiol-50 micron/day, levonorgestrel-250 micron/day, "Nordial"-a com... | 399,315 | [
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The intestinal flora and infant botulism. | The intestinal flora of experimental animals interferes with infection by species of Salmonella and Shigella. Protection against infection with these organisms appears to be related to high concentrations of volatile acids, low pH, and low oxidation-reduction potential of the intestinal contents of animals with an inta... | 399,374 | [
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Accounting for changes in family life of families with spina bifida children. | The use of time, division of household chores, and the use of resources outside the immediate family has been studied in 22 families with a spina bifida child aged between 4-6 years and compared with 22 families having a normal child of the same age group. In the families with a spina bifida child, both parents spent m... | 399,415 | [
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[Ensuring ureter viability: experimental study]. | 1. In experiments on dogs we observed that the remaining of the peripelvic and periureteral tissue in taking from the kidney is not decisive for the blood supply of the ureter. That these findings are important also for the clinic is confirmed by the following fact: in order to draw the ureter through the natireflux tu... | 399,421 | [
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Historical development of abstracting. | The abstract, under a multitude of names, such as hypothesis, marginalia, abridgement, extract, digest, précis, resumé, and summary, has a long history, one which is concomitant with advancing scholarship. The progression of this history from the Sumerian civilization ca. 3600 B.C., through the Egyptian and Greek civil... | 399,482 | [
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Using bibliometric analyses of patent literature for predicting the clinical fates of developing drugs. | Certain bibliometric features of the early literatures of developing drugs can be used to predict their ultimate clinical fates. The chronological sequence of publications is expressed as a binary vector with 1 for a patent and 0 for a nonpatent. The decimal equivalents for standardized vector lengths provide scalar va... | 399,483 | [
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[Ct-criteria of orbital hemangiomas and their importance in differential diagnosis of intraconal tumors (author's transl)]. | CT-scans of 29 histologically proven cavernous hemangiomas were evaluated with respect to their location, shape, delineation from surrounding tissue, contrast-enhancement, and secondary changes of the bony orbit. Whenever a round or oval tumor, located in the outer upper muscle cone, sharply delineated from surrounding... | 399,492 | [
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-0.6499982,
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-1.059875,
0.2294827,
0.3552259,
-0.09927144,
0.1473011,
0.04652768,
0.005802843,
... |
Elevated plasma adenine nucleotide levels in chronic renal failure and their possible significance. | Plasma ATP, ADP and AMP levels are increased in uremia. The elevation in plasma ATP level correlates with the serum creatinine in chronic renal failure patients not on dialysis. Successful renal transplantation is associated with the return of ATP, ADP and AMP levels to the normal range. Plasma ATP elevations may refle... | 399,505 | [
-0.2994778,
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... |
[Mutagenic action of platinum and palladium compounds on bacteria]. | Platinum complex compounds are shown to cause mutations in S. typhimurium strains, TA-100 and TA-98 bearing plasmid pKM-101 but not in isogenic strains TA-1535 and TA-1538 lacking the plasmid. The mutagenic action depended on the ligand nature in the complex and did not depend on the extent of the central atom oxidatio... | 399,702 | [
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... |
[Glucose tolerance and insulinemia in patients with hepatic cirrhosis and portal hypertension treated by portacaval anastomosis]. | Development of diabetes mellitus is a common complication of side to side porta-caval anastomosis (PCA). Five patients with liver cirrhosis and portal hypertension have been studied with intravehous (IVGTT, 0,5 g/Kg B.W.) and oral (OGTT, 1 g/Kg B.W.) glucose tolerance tests before and three weeks after PCA. Fasting pla... | 399,734 | [
0.2023245,
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-... |
Adjuvant immunotherapy. | Because systemic spread occurs early in the growth of many malignancies, control of occult micrometastases must be an integral part of cancer treatment. For this reason, surgery and radiation therapy alone may fail to achieve a cure despite eradication of the primary tumor. Chemotherapy is potent and systemic in its ef... | 399,764 | [
-0.1273787,
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0.1168402,
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[A definitive identification method: gas-liquid chromatography]. | The definitive identification of many anaerobes requires the use of gas-liquid chromatography to detect alcohol and volatile acids end-products of their metabolism. In this study we have used the gas-liquid chromatography for the identification of 360 non sporing anaerobes isolated from faeces of healthy individuals. T... | 399,837 | [
-0.1599555,
0.08559407,
0.02794672,
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0.2335865,
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[Unusual fatty acids in turkeys fed a diet containing "Toprina". I. Composition of the higher fatty acids in "Toprina", the diet, feces and blood]. | Totals lipids (TL) phospholipids (PL) and fatty acid composition of TL and PL (the latter in blood only) were estimated in Candida lipolytica cultivated on n-alkanes by industrial method ("Toprina"), in 0%, 10% and 15% "Toprina" diets and in faeces and blood of turkeys, males and females, fed these diets. With increasi... | 399,848 | [
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0.4340996,
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0.5432402,
-0.1961554,... |
Continuous and intermittent salbutamol tablet administration in asthmatic children. | We studied 22 asthmatic children aged seven years two months to thirteen years eight months over a four-month period. Each child received two months continuous and two months intermittent salbutamol tablets using a double-blind cross-over technique. No significant clinical differences were found between the two treatme... | 399,859 | [
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[Use of the intravisceral graft technic for the study of histologic changes in the skin after freezing]. | The authors present their technique for freezing thin skin samples which may be used for intravisceral grafts in the testis, the liver and the kidney to test developing potentials for grafts conserved in this manner. In comparison with fresh grafts, they show that frozen samples not only retained their vitality, but th... | 399,865 | [
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... |
Lysosomes and protein degradation. | Considerable evidence from studies with group-specific proteinase inhibitors, in particular pepstatin, the aspartic proteinase inhibitor, implicates lysosomes in turnover of endogenous cellular proteins. Recent experiments using a new group-specific inhibitor of thiol (cysteine) proteinases, Z-Phe-Ala-diazomethyl keton... | 399,886 | [
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0.1743471,
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0.3022107,
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Coordination of protein synthesis and degradation. | The degree of coordination between protein synthesis and protein degradation in developing and mature cels is considered. Studies on specific enzyme and general protein turnover in developing liver and differentiating mammary gland are presented. In the mature liver mitochondrion average protein degradation rates are h... | 399,891 | [
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... |
Effect of the co-carcinogen benzo[e]pyrene on microsome-mediated chemical mutagenesis in Salmonella typhimurium. | Chemical agents that possess the ability to alter tumorigenicity of carcinogens (administered at subthreshold dose) constitute a major health hazard. We have employed the Ames Salmonella assay to examine the effect of co-carcinogenic benzo[e]pyrene (B[e]P) on microsome-mediated chemical mutagenesis. B[e]P enhanced the ... | 399,907 | [
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0.4393074,
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... |
The mutagenicity of dialkyl nitrosamines in the Salmonella plate assay. | N-nitrosodimethylamine (DMN) is not mutagenic in the standard Salmonella plate incorporation assay (Ames test) in the presence of an in vitro metabolic activation system (S-9) derived from rat liver. When the S-9 was derived from Aroclor- or phenobarbital-induced mouse or hamster liver or from uninduced hamster liver, ... | 399,908 | [
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0.07543002,
... |
Problems associated with the application of short-term tests for mutagenicity in mass-screening programs. | The application of short-term tests for toxicological evaluation of environmental chemicals is certainly a reality in the near future as a result of the Toxic Substances Control Act, as well as other regulations under development [de Serres, 1977]. Many of the problems associated with this testing in the area of geneti... | 399,909 | [
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0.1664222,
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Mutagenic activity of epoxy embedding reagents employed in electron microscopy. | Components of epoxy-based embedding media used in electron microscopy were examined for their mutagenicity in the Ames Salmonella system. The compounds, singly and in combination, were shown to be active with strain TA100 (base substitution indicator) but not with TA98 (frameshift indicator). When tested separately the... | 399,914 | [
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0.0... |
Diethylaminoalkyloxycoumarin and -furocoumarin derivatives. | Four series of diethylaminoalkoxyderivatives of coumarin (at the positions 4 and 7) and furocoumarin (at the positions 5 and 8) have been prepared, in order to study their complexing capacity with DNA, these compounds having a double possibility of interaction, that is intercalation of the aromatic moiety between two b... | 399,924 | [
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0.3660889,
0.286189,
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... |
Arguments for an inhibiting role of prostaglandin E1 on insulin secretion in man. | This study aimed at investigating the effect of exogenous prostaglandin E1 (PGE1) administration on both basal and glucose-stimulated insulin secretion in normal man. For this purpose, six normal subjects were submitted to an infusion of PGE1 (0.2 microgram/kg/min) over a period of 75 min. Plasma glucose exhibited a pr... | 399,925 | [
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0.2266463,
0.2492... |
[S-acyl derivatives of thiosalicylamides and their anti-fungal activity. IV]. | Some S-acyl derivatives of N-alkylthiosalicylamides [Table I, II: substances (I leads to XXXIII)] in which the acyl group on S in a carbamic or thiocarbamic N-monosubstituted group were prepared and tested in vitro for antifungal activity. All the substances which are not previously recorded were prepared by condensati... | 399,927 | [
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0.1721607,... |
The treatment of infected pseudarthrosis. | Modern tendencies in the treatment of infected pseudarthrosis are discussed and compared with the methods of the recent past. Seventy four cases are analysed in detail. Fifty three were in the tibia, twenty six of which were treated by a standard modern technique consisting of osteomuscular decortication, excision of i... | 399,934 | [
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0.3967005,
0.02839579,
-0.01687... |
Alterations in the responses of the sympathetic nervous system and renin in borderline hypertension. | We investigated the effect of stimuli activate the sympathetic nervous system on plasma catecholamines, renin activity, urinary metanephrine and normetanephrine, and various hemodynamic parameters in normal subjects (NIs) and borderline hypertensive (BH) subjects. No differences were observed in sympathetic nervous sys... | 399,937 | [
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0.1723032,
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0.01925387,
0.1843... |
Osteogenic sarcoma: the past, present, and future. | The term osteogenic sarcoma (osteosarcoma) is applied to malignant bone-forming tumors, identifiable by the matrix produced, though the histologic pattern may differ greatly. Ths more cellular (osteolytic) forms of the tumor have the poorer prognosis. Other prognostic factors are 1) site of the primary tumor; 2) durati... | 399,944 | [
0.1153207,
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0.3723515,
0.1925934,
0.1215898,
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0.31... |
A quantitative study of muscle nerve sympathetic activity in resting normotensive and hypertensive subjects. | Recordings of multi-unit sympathetic activity were made from muscle branches of the peroneal or median nerves in 33 healthy and 12 hypertensive subjects resting in the recumbent position. Simultaneous recordings of intra-arterial blood pressure were made on 17 normotensive and all hypertensive subjects. The neural acti... | 399,941 | [
-0.07065986,
0.093798,
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0.3921628,
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0.2237536,
0.2814352,
-... |
Metabolic activation and deactivation of mutagens and carcinogens. | The activity of some mutagens has been investigated in the Salmonella test either in the absence or in the presence of fortified rat liver microsomal fractions, together with an NADPH-generating system. With respect to their metabolic reactivity, the compounds tested could be distinguished according to four reproducibl... | 399,955 | [
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... |
The primary structure of mitochondrial aspartate aminotransferase from pig heart: peptides obtained by cleavage at basic residues. | Results obtained as part of a study of the primary structure of mitochondrial aspartate aminotransferase from pig heart are described. In particular, the S-aminoethylated protein was digested with trypsin and with the lysine specific protease from A. mellea. In the first case peptides contained 221 out of the total of ... | 399,957 | [
-0.3663206,
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0.3583695,
0.1978663,
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Epizootiology and control of anaplasmosis in south africa. | The history of bovine anaplasmosis, or tick-born gallsickness, since the discovery of Anaplasma marginale by Sir Arnold Theiler is briefly reviewed. The development of the Anaplasma centrale vaccine by Theiler, up to the composition of the present vaccine issued by Onderstepoort in which the original isolate is still p... | 399,978 | [
-0.2509387,
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0.01934369,
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0.1302627,
-0.09927496... |
[Creatinine clearance: indirect estimate (author's transl)]. | The validity of some formulas proposed to estimate the creatunine clearance by values of serum creatinine and others non analytical parameters (sex, age, weight and height) was tested in a group of 200 adults (100 males and 100 females) and in a group of 134 children (80 males and 54 females). The age ranged from 1 mon... | 400,030 | [
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0.4413994,
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-0.2528085,
... |
Long-term effects of pancreatic transplant function in patients with advanced juvenile-onset diabetes. | Present methods of management of juvenile-onset diabetes mellitus do not prevent serious and debilitating complications affecting multiple organ systems. In an effort to reverse advanced forms of these complications, segmental transplantation of the pancreas has been performed on 10 patients, seven of whom simultaneous... | 400,124 | [
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0.1378564,
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0.08757742,
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0.07465804,
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0.2117363,
0.1609351,
0.0823776,
0.03484... |
Urine glucose tests for diabetic patients with impaired vision. | A colorimetric test procedure called Mega-Diastix is described for detection and measurement of glucose in urine. The test is designed for use by diabetic patients with imparied vision. Data establishing the performance capabilities of this rapid, convenient test are presented. As an internal standard, the recommended ... | 400,125 | [
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Use of fructose, xylitol, or sorbitol as a sweetener in diabetes mellitus. | Nonnutritive sweeteners have been utilized in the diet of diabetic patients an an agent to replace glucose and sucrose. Since saccharin might be removed from the marketplace, the nutritive sweeteners fructose, xylitol, and sorbitol are being considered as possible alternatives for glucose and sucrose. This review consi... | 400,132 | [
-0.2761167,
0.1753667,
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The Ligurian coast: an example of data processing. | An attempt of computer data processing carried out on microbiological analysis of marine coastal waters is reported in the present paper. The Ligurian coast was chosen because of the extensive analyses executed by the Laboratori Provinciali di Igiene e Profilassi. These have supplied us with their results concerning th... | 400,219 | [
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["S. wien" and "S. bredeney" plasmidic resistance to disinfectant agents and antibiotics (author's transl)]. | Several antiseptic and disinfectant compounds have been investigated for their minimal inhibitory concentration (MIC) against antibiotic multiresistant strains of S. wien and S. bredeney as well as S. typhi and S. typhimurium strains characterized by wide spectrum of antibiotic sensitivity. The MICs of AgNO3, merthiola... | 400,256 | [
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[Continuing Education Course of the Swiss Society for Psychiatry. Biological aspects of psychiatry. Introduction]. | The author traces the prestigious history of the Burghölzli, cradle of Swiss psychiatry. He also describes the outstanding role played by Zurich as the city in which integration took place between the developing psychiatry, psycho-analysis, psychodynamics and biological research. The author shows how psychiatry, which ... | 400,261 | [
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Electroencephalographic and histopathological correlations on Jakob-Creutzfeldt disease. | Three patients with Jakob-Creutzfeldt disease were studied. The clinical evolution was followed and several EEG controls were made. In all patients characteristic EEG abnormalities were present. Histopathological features in the cortical, subcortical grey matter and in the white matter were examined. Subcortical and co... | 400,366 | [
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[Heterotopic transplantation of rat liver. Preliminary observations with the scanning electron microscope (SEM)]. | An eterotopic grafting of their livers has been made between two inbred rats. From 30 to 50 days later the livers has been observed through OM or SEM. In the first case (OM) there was evidence of vacuolar degeneration of liver cells gradually decreasing on the 50th day. In the latter case (SEM) the morphological appear... | 400,383 | [
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[Effects of some prostaglandins on plasma levels of prolactin in the rat]. | In ovariectomized rats treated with estradiol benzoate the ICV introduction of PGE1, 11-deoxy-13,14-didehydro-16S-methyl-PGE2, PGI2 or 6 H-PGI1 produces a marked increase of the plasma prolactin levels. These results suggest that the PGs play a role in the regulation of the prolactin secretion. | 400,384 | [
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Metronidazole for chronic diarrhoea in children. | A double blind prospective controlled trial of metronidazole was performed on children admitted to Goroka Hospital with diarrhoea for seven days or more. There was no significant difference in the duration of diarrhoea after treatment began between children given metronidazole (4.3 days) and those given placebo (4.1 da... | 400,464 | [
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Deoxythymidine sugars are not direct precursors of DNA-thymine. | A theoretical model for the kinetics of uptake of a putative precursor molecule into nucleotide pools and into replicating DNA has been developed. The relationship between the accumulation of radioactively labeled precursors in the pool and the appearance of radioactivity in DNA is then derived. Experiments have been c... | 400,471 | [
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Acute endotoxin shock in the dog and an attempt at its therapy. | The present study aimed at monitoring of hemodynamic changes proceeding in a standard model of acute endotoxin shock in the dog, and mainly at an attempt at the therapy of its early phases. Acute endotoxin shock represents a grave state with rapidly advancing changes in blood circulation, therefore we studied the effec... | 400,547 | [
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Increased insulin binding to monocytes after acute exercise in normal man. | The effect of exercise on 125I-insulin binding to monocytes was studied in 10 healthy subjects. We found that acute exercise (bicycle ergometer for 3 h) led to a significant increase (36%) in insulin binding to monocytes, which returned to basal levels by 24 h after exercise. The changes in insulin binding were mainly ... | 400,712 | [
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Gastric inhibitory polypeptide in acquired pancreatic diabetes: effects of insulin treatment. | Oral glucose tolerance tests were done in eight insulin-requiring pancreatic diabetic patients to study the effect of withdrawal of insulin treatment on gut hormone release. Basal levels of gastric inhibitory polypeptide (GIP), glucagon-like immunoreactivity, and immunoreactive glucagon levels rose on insulin withdrawa... | 400,725 | [
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Correlations between plasma renin activity, angiotensin II, and aldosterone. | To obtain more information about the relationships of the components of the renin-angiotensin-aldosterone system, we measured plasma renin activity (PRA) and the concentrations of plasma angiotensin II (AII) and aldosterone (PA) in 36 healthy 19-22-yr-old students, both after a night's bed rest and after 2 h of ambulat... | 400,729 | [
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Diurnal 18-hydroxy-11-deoxycorticosterone pattern in human stable hypertension. | Diurnal 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) pattern was studied with RIA technique in 33 hypertensive patients in supine position and on normal sodium diet. The compound was evaluated every 2 h from 0800-2000 h. Simultaneously, plasma aldosterone and cortisol were measured. Abnormal 18-OH-DOC behavior was obs... | 400,733 | [
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The regulation of the release of granulocytes from normal marrow. | Figure 16 synthesizes the various aspects of marrow egress. The central anatomical relationship of the hematopoietic compartment to vascular sinus is shown above. The hatched blocks represent the sinus wall, capable of developing narrow migration channels. In the marrow, immature granulocytes alter their biophysical ch... | 400,761 | [
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National Health Insurance: a political issue at the crossroads. | It is safe to assume that a comprehensive NHI plan will not be enacted prior to the next presidential election. In sum, immediate action on the NHI issue is unlikely. However, enactment of a mini-NHI plan, expanding the Medicare and Medicaid programs, providing catastrophic coverage and/or providing coverage for mother... | 400,767 | [
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Mechanisms of impaired acute insulin release in adult onset diabetes: studies with isoproterenol and secretin. | Previous work has suggested that impaired islet glucose recognition occurs in patients with adult onset diabetes, as acute insulin release is absent after iv glucose but present after beta adrenergic stimulation with isoproterenol (Iso). However, insulin responses to Iso were variably reduced as compared to normal in t... | 400,768 | [
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Deoxyribonucleic acid repair in Escherichia coli mutants deficient in the 5'----3' exonuclease activity of deoxyribonucleic acid polymerase I and exonuclease VII. | A series of Escherichia coli strains deficient in the 5'----3' exonuclease activity associated with deoxyribonucleic acid (DNA) polymerase I (exonuclease VI) and exonuclease VII has been constructed. Both of these enzymes are capable of pyrimidine dimer excision in vitro. These strains were examined for conditional let... | 400,786 | [
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Deoxyribonucleic acid synthesis after inhibition of initiation of rounds of replication in Escherichia coli B/r. | The theory describing the effect of inhibition of initiation of rounds of deoxyribonucleic acid (DNA) replication on the accumulation of DNA is derived, and an analysis is presented which allows the determination of the time C taken to replicate the bacterial chromosome from the kinetic changes in the accumulation of D... | 400,788 | [
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Cell division in Escherichia coli BS-12 is hypersensitive to deoxyribonucleic acid damage by ultraviolet light. | Escherichia coli BS-12 uvrA lon is hypersensitive to ultraviolet light. On minimal agar plates at densities in excess of about 10(7) bacteria per plate, as few as one or two photoreversible pyrimidine dimers in the entire genome are sufficient to cause inhibition of cell division. Most of the resulting filaments are un... | 400,790 | [
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Regulatory changes in the fucose system associated with the evolution of a catabolic pathway for propanediol in Escherichia coli. | Wild-type strains of Escherichia coli are unable to use L-1,2-propanediol as a carbon and energy source. Strain 3, a mutant selected for the ability to grow on this compound at progressively more rapid rates, synthesizes constitutively a nicotinamide adenine dinucleotide-linked propanediol oxidoreductase. This enzyme i... | 400,796 | [
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Coordinate control of the synthesis of ribonucleoside diphosphate reductase components in Escherichia coli. | Ribonucleoside diphosphate reductase subunits B1 and B2 and ether-permeabilized cell activities of Escherichia coli increase in parallel during thymine deprivation. Thioredoxin and thioredoxin reductase activities are not affected by thymine deprivation. | 400,802 | [
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Pneumocystis carinii infection: evidence for high prevalence in normal and immunosuppressed children. | Using Pneumocystis carinii organisms propagated through three passages in embryonic chick epithelial lung cultures, specific antigens and antisera were prepared for use in counterimmunoelectrophoresis and indirect immunofluorescent antibody techniques. These methods proved to be specific and sensitive for the detection... | 400,818 | [
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The Fasanella-Servat operation. | Indications, complications, surgical anatomy and the author's method of performing the FSO have been described. The procedure is an excellent and predictable operation if the criteria which have been advocated by many authors are carefully followed. | 400,838 | [
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The McCarey-Kaufman medium and penicillin allergy. | Thirty-four donor corneas previously stored in McCarey-Kaufman medium containing 100 u/ml of penicillin G were transplanted into 32 recipients with a given history of penicillin allergy. There were no early or late ocular or systemic postoperative complications that could be related to a history of penicillin allergy. ... | 400,847 | [
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Gray scale ultrasound for the investigation of early pregnancy. | 73 early gestations (6-14 wk) were investigated with gray scale ultrasound. 7 of them ended in spontaneous first-trimester abortion, and in all of these the findings were characteristic for spontaneous interruption of pregnancy. The remaining 66 continued to term. Regression analysis was performed with respect to the d... | 400,859 | [
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Adverse effects of water-soluble contrast media in myelography, cisternography and ventriculography. A review with special reference to metrizamide. | The adverse effects following lumbar myelography and ventriculography with meglumine iothalamate (Conray Meglumin), meglumine iocarmate (Dimer-X, Bis-Conray) and metrizamide (Amipaque), and after thoracic and cervical myelography and cisternography with metrizamide are reviewed. In addition to the published material in... | 400,906 | [
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A study of the effect of ultraviolet light on the division potential of human diploid fibroblasts. | Culture and UV (254 nm) irradiation conditions that are suggested as appropriate for a study of the effect of UV on the limited in vitro lifespan of a normal human diploid fibroblast (HDF) strain are first described. An inoculation density at each subcultivation of 1.8 x 10(4) viable cells/cm-2 permits the decline in p... | 400,910 | [
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0.5093641,
-0.238614... |
Sequelae of stomach surgery. | Gastric surgery has undergone continuous evolution since the 19th century. At present it is a highly sophisticated technique which provides symptomatic relief for the vast majority of patients operated upon for peptic ulcer disease. Although the overall incidence of complications has decreased, a variety of complicatio... | 400,915 | [
-0.1151193,
-0.3385405,
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0.2085769,
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0.1016546,
0.1541674,
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Safety of cefoxitin: an approach to the analysis of laboratory data. | The safety of cefoxitin, in terms of values obtained in laboratory tests during and after therapy, was estimated by three methods for analysis of data derived from controlled clinical comparisons of cephalothin and cefoxitin. Both antibiotics were found to be safe with respect to hematologic, renal, and hepatic functio... | 400,935 | [
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0.5110846,
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0.02633523,... |
Induction and effector phases of the immune response: physiological and pathophysiological features. | A review is given on the current state of knowledge about the induction and effector phases of the immune response. Physiological and pathophysiological features of the regulation of the immune response are discussed comparatively for both man and animals. | 400,943 | [
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0.07627521,
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... |
Schistosoma mansoni: inhibition of cercarial "penetration" proteases by components of mammalian blood. | 1. Normal human sera and plasma were fractionated in order to identify inhibitors of the "penetration" proteases of Schistosoma mansoni cercariae. 2. The main inhibitor, accounting for 90% of the total activity of serum, appears to be alpha 1-antitrypsin (alpha 1-AT) as identified by separation on DEAE-cellulose and Se... | 400,950 | [
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0.2353819,
0.01004039,
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0.24... |
Amino acid differences between major and minor hemoglobins from lemmings (Lemmus and Dicrostonyx). | 1. Dual hemoglobins were isolated from both Lemmus and Discrostonyx, two genera of microtine rodents of the tribe Lemmini. 2. The dual hemoglobins result from dual alpha-chains and the charge difference Asp----Ala at position alpha 5. 3. The beta-chains of Dicrostonyx and Lemmus hemoglobins differ in charge by Ala----A... | 400,959 | [
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0.3604452,
0.393957,
0.3524452,
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0... |
Inhibition of the NADP-linked glutamate dehydrogenase from Trypanosoma cruzi by sulfhydryl reagents. | 1. The NADP-linked glutamate dehydrogenase purified from epimastigotes of Trypanosoma cruzi was strongly, but not completely, inhibited by sulfhydryl reagents, in the presence of Tris-HCl or phosphate buffers. 2. The enzyme modified by preincubation with o-iodosobenzoate had a kinetic behaviour different from that show... | 400,963 | [
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0.06490325,
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0.5451724,
0.01859413,
0.2247316,
0.03195449... |
Antenatal detection of fetal pleural effusions and neonatal management. | The ultrasonic findings in a living fetus with bilateral pleural effusions are described, and the possible lines of management are discussed. | 400,968 | [
-0.06134626,
0.1776211,
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0.04470025,
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0.2516826,
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-0.098831... |
Depression and monoamine oxidase. | 1. The first part of the paper is devoted to a critical review on the possible relationships between depression and monoamine oxidase. 2. This study describes the results of an investigation of MAO-activity in depression, using new approaches and methodology. This methodology was developed because the literature data i... | 401,000 | [
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0.2037726,
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0.5054952,
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0.1964682,
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... |
Seasonal changes of plasma estradiol and progesterone in the Japanese monkey (Macaca fuscata fuscata). | The plasma levels of estradiol and progesterone in 5 mature female Japanese monkeys (Macaca fuscata fuscata) throughout a breeding and nonbreeding season were measured by radioimmunoassay. As the breeding season approached, plasma estradiol levels started to increase and a few elevations were detected. However, neither... | 401,026 | [
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0.186812,
0.2034725,
0.2261371,
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0.2320005,
0.0276429,
-0.2186594... |
Role of TSH in the changes in thyroidal metabolism of [35S]methimazole in phenobarbital and thyroxine-treated rats. | The effect of phenobarbital (PB) and/or thyroxine on the thyroidal accumulation and oxidation of [35S]methimazole (MMI) and serum TSH levels was studied in rats. PB treatment increased the accumulation of MMI and the serum TSH levels, but concurrent administration of T4 reversed these effects. It was concluded that inc... | 401,027 | [
0.0066773,
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-0.1546334,
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0.1135247,
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0.2759749,
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0.1391179,
0.07953878,
0.1595987,
0.04624211,
0.2179234,
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0... |
Immunoreactive LH-like substances in serum of hypophysectomized and prepubertal monkeys: inactive in an in vitro LH bioassay. | Serum LH levels in rhesus monkeys are commonly measured by a radioimmunoassay (RIA) utilizing ovine LH as the radioligand and a novel antiserum to ovine LH. Although meeting most criteria of validity, this RIA cross-reacts with serum from demonstrably hypophysectomized monkeys as well as serum from pre-pubertal monkeys... | 401,031 | [
0.2217921,
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-0.3408186,
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0.5391943,
0.3849473,
0.3269343,
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0.08726941,
0.3557197,
0.1829299,
0.2812235,
0.1571253,
-0.08421692,
... |
H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats. | The aim of the present research was to evaluate the histaminergic regulation of prolactin secretion in the lactating rat and the possible involvement of H1 and H2 histamine receptors in this control. Prolactin was measured by radioimmunoassay in blood samples withdrawn through an intrajugular silastic catheter from und... | 401,035 | [
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0.01143362,
0.2823631,
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0.0403907,
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-0.3557504,
0.05352109,
0.2106927,
0.16717... |
Prothesis cement envelope in femoral component total hips. | Loading tests showed wide stem-thin cement envelope systems in valgus orientation placed with distal plug to be significantly more stable at higher loads. Narrow stem-thick cement envelope systems in varus without plug were unstable within a marginal factor of safety for cyclic loading. Four cement failures occurred wi... | 401,259 | [
0.01571845,
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0.0322118,
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0.5094107,
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0.3409023,
0.1120283,
0.2241... |
Preparation of allogeneic cartilage and bone for grafting. | Seroma formation was most apparent in the A-treated groups and was probably related to the continued leakage of methyl alcohol from the graft. Warping in the pinna, fibrosis around grafts, graft resorption, and cellular infiltration were least evident in the FZ and R groups. Both produced better results than storage in... | 401,270 | [
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0.4908885,
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-0.2136881,... |
Drug induced modulation of immune responses in mice: effects of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) and cyclophosphamide (Cy). | Graded doses of Cyclophosphamide (Cy) or 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) were given to CD2F1 or C57Bl/6 mice. One, 45 or 60 days later the animals were tested for allograft responses, competence of producing cytotoxic lymphocytes in vitro and lethal graft-versus-host disease (GVHD) in vivo, d... | 401,314 | [
-0.0610572,
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0.1696616,
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0.3840756,
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0.3569041,
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0.... |
Treatment of mental disorders in India. | 1. Mental health gets a low priority all over the world but much more so in developing countries. 2. In India, modern psychiatric facilities are available only in the cities. Mental hospitals are becoming modernized but the backbone of psychiatry is the psychiatric department in the General Hospital where treatment is ... | 401,334 | [
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0.1172084,
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... |
Genetic epidemiology and the prevention of functional mental disorders and alcoholism: family study and biological predictors. | 1. This review intends to present some theoretical and practical considerations which appear essential for the development of rational research strategies in the field of primary and secondary prevention of mental disorders and alcoholism. 2. The various advances and trends regarding the nosology and diagnosis of these... | 401,338 | [
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0.06605071,
0.1864677,
0.0588831,
0.04821629,
0.144658,
-0.3621939,
0.067... |
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