title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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The role of plasma concentrations in the use of tricyclic antidepressant drugs. | 1. The range of tricyclic antidepressant plasma levels (or doses) needed for therapeutic response remains largely unresolved, since quantal plasma concentration (or dose)--response relationships have not been clearly defined for either therapeutic or nontherapeutic effects. 2. The fact that certain patients apparently ... | 401,340 | [
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The mechanisms of human tumour-induced osteolysis and hypercalcaemia. | This is a brief resume of the current knowledge regarding the mechanisms whereby tumours may cause the breakdown or increase the turnover of bone matrix resulting in hypercalcaemia. The precise mechanisms and agents still remain to be ascertained. This would appear to be an investigative area worthy of significant rese... | 401,332 | [
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Psychopharmacological prospectives in the treatment of dementia. | 1. Dementias have a complex etiology and pathogenesis which should be carefully evaluated in order to attempt a medical treatment. 2. Drugs are among the most frequent causes of dementias, particularly drugs with anticholinergic properties. 3. A similarity between the mental symptoms of anticholinergic poisoning and se... | 401,345 | [
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Childhood family influences on risk of alcoholism. | 1. The self-destructive behavior of chronic, excessive drinking is motivated by self-hatred in combination with ambivalent expressions of ambition and dependency. These sources of vulnerability to alcoholism develop in early childhood. 2. The protective influence of a favorable, stable self-evaluation is indicated by c... | 401,354 | [
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Genetic markers in depressive disorders. | 1. Association or linkage between a known genetic marker and an illness with a presumed genetic etiology supports two conclusions: a) The genetic etiology would be considered definite, and b) the illness should be considered a homogeneous disease. 2. After separating depressions on the basis of gross familial differenc... | 401,356 | [
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Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin, and 5-methoxytryptamine. | The effects of pineal indole compounds on the response of the neonatal rat anterior pituitary gland to LH-releasing hormone (LHRH) were studied in organ culture. After 24 h of culture under control conditions, pituitary glands from 5-day-old female rats were routinely incubated for an additional 24 h with the test comp... | 401,360 | [
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Serum ferritin assay. | Ferritin is an iron storage protein of high-molecular weight which is primarily present in the liver, spleen, and bone marrow. A very sensitive immunoradiometric assay has been developed which permits determination of serum concentrations in normal persons and in patients with a variety of different disorders. In norma... | 401,369 | [
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Late development of severe pulmonary venous obstruction following the Mustard operation. | While four patients with d-transposition of the great arteries who had a Mustard operation before 2 years of age developed severe pulmonary venous obstruction 2, 3 1/2, 3 9/12, and 5 years following their operation, initial postoperative catheterization (less than 1 year) revealed only minimal pulmonary artery wedge an... | 401,442 | [
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Peroxisomes (microbodies) in the myocardium of rodents and primates. A comparative Ultrastructural cytochemical study. | The occurrence of peroxisomes (microbodies), their cytochemical characteristics and their ultrastructural relationship to the neighboring organelles were investigated in the ventricular myocardium of four rodent (rat, rabbit, gerbil, and guinea pig) and two primate (Macaca java and Tupaya) species. The hearts were fixe... | 401,475 | [
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Subtyping of hepatitis B surface antigen and antibody by radioimmunoassay. | The hepatitis B surface antigen (HBSAg) has been shown to possess distinct subtypes adw, ayw, adr, and ayr). A commercially available solid phase radioimmunoassay for antibody to HBSAg (Ausab, Abbott Laboratories North Chicago, Ill.) has been modified to detect the subtypes of HBSAg as well as the subtype-specific anti... | 401,489 | [
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Role of sugar uptake and metabolic intermediates on catabolite repression in Bacillus subtilis. | Many phosphorylated intermediates exert catabolite repression on the enzyme acetoin dehydrogenase in Bacillus subtilis. This was shown with strains that are blocked at different positions in central metabolism when they receive sugars that cannot be metabolized past enzymatic block(s). In the case of sorbitol, transpor... | 401,492 | [
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Bacillus subtilis bacteriophage SPbeta: localization of the prophage attachment site, and specialized transduction. | The attachment site for the prophage of SPbeta lies between ilvA and kauA on the chromosome of Bacillus subtilis strain 168. Specialized transduction of citK and kauA can be carried out by certain lysates of SPbeta. | 401,505 | [
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Human beta-glucuronidase deficiency mucopolysaccharidosis: identification of cross-reactive antigen in cultured fibroblasts of deficient patients by enzyme immunoassay. | An enzyme immunoassay for human beta-glucuronidase was developed to determine the presence or absence of antigenically cross-reactive material (CRM) in patients with beta-glucuronidase deficiency mucopolysaccharidosis. This assay provided a sensitive means of measuring the primary interaction between the enzyme molecul... | 401,508 | [
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Effect of sensitization with Propionibacterium acnes on the growth of Listeria monocytogenes and Treponema pallidum in rabbits. | Sensitization of rabbits with Propionibacterium acnes, a nonspecific stimulant of the reticuloendothelial system, was investigated as a means of enhancing resistance to Treponema pallidum. A single i.v. dose of P. acnes given 3 or 7 days before challenge with Listeria monocytogenes was capable of suppressing the growth... | 401,511 | [
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Defense mechanisms against primary influenza virus infection in mice. I. The roles of interferon and neutralizing antibodies and thymus dependence of interferon and antibody production. | To investigate the defensive roles and production of interferon and antibodies, C3H/He mice were subjected to various immunosuppressive treatments and infected with influenza virus. In infected normal control mice the pattern of pulmonary viral growth can be divided into three phases. The first phase is characterized b... | 401,512 | [
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Indium-111-labeled leukocytes for the localization of abscesses: preparation, analysis, tissue distribution, and comparison with gallium-67 citrate in dogs. | Leukocytes have been labeled with indium-111-8-hydroxyquinoline complex. Seventy-five to 85 per cent of the initial activity has been obtained in the complex form of which 75 to 95 per cent is incorportaed with leukocytes. The polymophonuclear leukocytes are predominantly labeled, and the label has been found stable fo... | 401,519 | [
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Treatment of pulmonary infections in patients with cystic fibrosis: a comparative study of ticarcillin and gentamicin. | The effectiveness of ticarcillin against Pseudomonas aeruginosa in acute exacerbations of pulmonary infection in patients with cystic fibrosis was evaluated. Seventy-one percent of patients treated with ticarcillin alone responded favorably. The response rate was similar in patients treated with a combination of ticarc... | 401,521 | [
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[Prevention of meningococcal meningitis]. | Meningococcal meningitis as well as meningococcal sepsis must be regarded as complications of an otherwise mild meningococcal infection of the nasopharynx. Only individuals without antibodies against a given meningococcal type will contract the above-mentioned diseases. Causal prophylactic measures have proved to be in... | 401,542 | [
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Congenital transmission of a papovavirus of the stump-tailed macaque. | Stump-tailed macaque virus, a newly recognized papovavirus of the SV40 polyoma subgroup, was demonstrated in kidney cultures from each of five stump-tailed macaque fetuses in the second half of gestation and from six adult stump-tailed macaques. Such regular presence of virus in the fetus is an unusual feature for a pa... | 401,546 | [
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Measurement of complement components in systemic lupus erythematosus by radial immunodiffusion. | Total hemolytic complement activity (CH50) and levels of C4, C5, and Factor B determined by commercially available radial immunodiffusion plates were compared in sera from patients with systemic lupus erythematosus. There was a significant correlation between CH50, C4 and C5, but no correlation between Factor B and any... | 401,557 | [
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The anatomic splenic flexure: an ultrasonic renal impostor. | The anatomic splenic flexure of the colon occupies the left renal fossa in patients with agensis or ectopic of the left kidney. On ultrasonic scans, the colon filled with stool or fluid may simulate a kidney or mass. This mass is often comma shaped on the transverse scans and lacks good definition of its inferior margi... | 401,565 | [
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Invasion of the duodenum by carcinoma of the stomach. | It has frequently been stated that extension to the duodenum occurs commonly in patients with gastric lymphoma but almost never in those with carcinoma of the stomach. We found radiographically detectable invasion of the duodenum in six of 111 consecutive patients (5%) with gastric carcinoma. The duodenum was involved ... | 401,601 | [
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Micro-balloon catheter for superselective angiography and therapeutic occlusion. | A miniature (0.5 mm) flow-directed balloon catheter with two different silastic balloon tips has been developed. One tip is used for perfusion; the other can be inflated and released to produce vascular occlusion. Examples of the developmental work in dogs and clinical use in patients are presented. | 401,606 | [
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Pericarditis in diabetic ketoacidosis. | A 25-year-old insulin-dependent diabetic man who was admitted to hospital with severe diabetic ketoacidosis and dehydration showed sequential electrocardiographic abnormalities of acute pericarditis. Though the patient had retrosternal chest pain, no pericardial friction rub was heard. None of the usual causes of peric... | 401,643 | [
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Radiation therapy in the management of localized carcinoma of the prostate: a preliminary report. | Since 1970 a total of 107 patients has been treated radically with radiation therapy for carcinoma of the prostate. The local control with this form of treatment is over 90%. The five year actuarial survival is 74% and the disease-free survival 58%. Serious morbidity has been minimal. Survival is related to the extent ... | 401,678 | [
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Destruction of experimental malignant melanoma by mediators of cellular immunity. | Listeria monocytogenes (LM) in admixture with B-16 melanoma suppresses local tumor development in syngeneic C57BL/6 mice. In vitro, LM-immune peritoneal and splenic cells are cytotoxic to B-16. Induction of cell-mediated immunity to LM antigens are required for the killing effect, since effector cells from LM-"immune" ... | 401,681 | [
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A patient with purine nucleoside phosphorylase deficiency: enzymological and metabolic aspects. | 1. Enzymological and metabolic data in a patient with nucleoside phosphorylase (NP) deficiency are described. 2. Incubation of intact NP-deficient red cells with [14C]adenosine showed a rapid uptake and conversion to inosine. Almost no radioactivity was incorporated in the adenosine nucleotides and no hypoxanthine labe... | 401,697 | [
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Fosfomycin, antimicrobial activity in vitro and in vivo. | Antibacterial activities of fosfomycin were investigated both in vitro and in vivo for the purpose of comparative evaluation on its fundamental properties with other antimicrobial agents. The MIC was determined with nutrient agar (Difco) inoculated with one loopful of 1,000-fold dilution (about 10(6) cells/ml) of bacte... | 401,721 | [
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0.2410289,
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0.4043274,
0.08426289,
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0.14884... |
Evolution of sensitivity to fosfomycin at Jimenez Diaz Foundation. | The sensitivity to fosfomycin of more than 8,000 strains of bacteria isolated from products recevied by the laboratory between 1972 and 1974 has been studied. Some were studied by the dilution technique in a solid medium and the remainder was studied by diffusion. A single 50-mug disc was used and the strains inhibited... | 401,722 | [
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Delayed hypersensitivity in Graves' disease and exophthalmos: identification of thyroglobulin in normal human orbital muscle. | Patients with Graves' disease and exophthalmos demonstrate delayed hypersensitivity to antigens present in extracts of certain normal human tissue; namely,thyroid gland and retroorbital tissue. The delayed hypersensitivity can be assayed in vitro by quantitating the amount of a lymphokine, migration inhibition factor (... | 401,730 | [
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Influence of vasopressin on colon blood flow in monkeys. | Inferior mesenteric arterial blood flow was measured with an electromagnetic blood flowmeter in five anesthetized rhesus monkeys. The effects of vasopressin on this vasculature were determined to evaluate the optimal, safe concentration of this agent during its clinical application in the management of hemorrhagic lesi... | 401,750 | [
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Why did the strepsirhine tooth comb evolve. | The hypothesis that the original strepsirhine tooth comb evolved for scraping gum is examined. The comparative morphology of the anterior dentition does not corroborate this view, and our study suggests that the primitive tooth comb, which was 6-toothed, evolved for the maintenance of the five, evenly distributed narro... | 401,757 | [
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High pressure liquid chromatographic determination of 4,4'-(diazoamino)-dibenzenesulfonic acid in FD&C yellow no. 6. | Fourteen analysts from 9 laboratories evaluated a high pressure liquid chromatographic procedure for the determination of 4,4'-(diazoamino)-dibenzenesulfonic acid (DAADBSA) in FD&C Yellow No. 6. Each collaborator analyzed 5 samples nominally containing 0-0.050% DAADBSA. The repeatability and reproducibility of the ... | 401,804 | [
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Activation of rat adipocyte glycogen synthase by insulins. | Incubation of fat cells with insulin increased glycogen synthase I activity without changing total synthase activity. This effect of insulin was dependent upon the particular lot of albumin present in the medium and was abolished by incubating cells with trypsin. Half-maximal activation of glycogen synthase was obtaine... | 401,814 | [
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Low serum triiodothyronine (T3) and hypothyroidism in anorexia nervosa. | Measurements of serum thyroid hormones were compared in 22 patients with typical anorexia nervosa and 22 euthyroid control subjects. Serum total triiodothyronine (T3) was (mean +/- (SE) 62.1 +/- 7.1 ng/100 ml in anorexia patients and 115.2 +/- 8.4 ng/100 ml in control subjects (P less than 0.001). Serum adjusted thyrox... | 401,822 | [
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Effect of triiodothyronine treatment on prolactin secretion in patients with amenorrhea-galactorrhea. | In order to determine the role of thyroid hormone in prolactin (PRL) secretion in patients with amenorrhea-galactorrhae, PRL response to 500 mug of iv thyrotropin-releasing hormone (TRH) was studied before and after the administration of triiodothyronine (T3) in 10 patients with amenorrhea-galactorrhea. Seven of these ... | 401,825 | [
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... |
Diphosphonate therapy of paget's disease of bone. | The use of disodium ethane-1 hydroxy-1, 1-diphosphonate (EHDP) therapy for Paget's disease of bone was examined in 75 affected patients. Forty-eight patients received randomly assigned oral doses of either 0, 2.5, 5, 10, or 20 mg/kg/day in a controlled, double-blind protocol, and the remainder received either 10 or 20 ... | 401,827 | [
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Demonstration of bilateral projection of the central retina of the monkey with horseradish peroxidase neuronography. | In the primate, ganglion cells of the temporal retina project ipsilaterally and those of the nasal retina, contralaterally into the optic tract. The vertical meridian passing through the fovea defines the border between these two populations of ganglion cells and has been demonstrated in four Macaque monkeys after unil... | 401,836 | [
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Role of striate cortex and superior colliculus in visual guidance of saccadic eye movements in monkeys. | 1. We studied the effect of lesions placed in striate cortex or superior colliculus on the detection of visual stimuli and the accuracy of saccadic eye movements. The monkeys (Macaca mulatta) first learned to respond to a 0.25 degrees spot of light flashed for 150-200 ms in one part of the visual field while they were ... | 401,874 | [
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Brain-tumor chemotherapy. Pharmacological principles derived from a monkey brain-tumor model. | An implnated choriocarcinoma growing inthe brains of monkeys was used as a brain-tumor model for the study of the cerebral distribution of two commonly used physiological markers, inulin and albumin; tissue samples were obtained from the tumor, adjacent brain, and distant brain. An extravascular inulin space was calcul... | 401,875 | [
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Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds. | Benzyl isothiocyanate and phenethyl isothiocyanate, two compounds found in cruciferous plants, and phenyl isothiocyanate, a synthetic compound, all inhibit 7,12-dimethylbenz[a]anthracene (CMBA)-induced mammary tumor formation in female Sprague-Dawley rats when administered 4 hours prior to the DMBA. Comparable studies ... | 401,894 | [
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[TRH refractory TSH values, triiodothyronine levels and T3/T4 quotients in hypothyroid children treated with T3/T4 preparations (author's transl)]. | TRH-tests, triiodothyronine (T3), TBI, and thyroxine (T4) determinations were carried out in 23 children with primary hypothyroidism treated with T3/T4-preparations. T3/T4 quotients were calculated. 7 out of 10 patients with TRH refractory TSH values and normal T4 levels had T3 values above normal range. In 6 of them p... | 401,919 | [
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Clinical use of the anion gap. | The concepts underlying the clinical use of the anion gap (AG) and those disorders associated with its alteration are reviewed. A substantial increase in the AG usually indicates the presence of a metabolic acidosis, unless large doses of certain antibiotics or sodium salts of organic acids are being used. The etiology... | 401,925 | [
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Herpes simplex keratitis. | This article reviews the current concepts for the diagnosis and treatment of Herpes simplex keratitis and its complications, discussing characteristics of the virus, the prevalence of the disease, chemical and clinical differentiation between Types I and II Herpesvirus hominis, and the many clinical presentations of Ty... | 402,036 | [
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[Thyroid function following thyroidectomy determined by the TRH-induced release of thyrotropin (author's transl)]. | The response of hTSH to TRH (400 mug i.v.) was studied in 45 patients who underwent thyroid surgery for various reasons. Euthyroid values of T4 and ETI were observed in all but one patient. An increased response of hTSH to TRH (as compared with 15 control subjects) was observed in 12 out of 30 patients operated upon fo... | 402,051 | [
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The relationship between expression of epithelial B-like blood group antigen, cell movement and cell proliferation. | Healing wounds in the oral mucosa of rhesus monkeys were examined by an immunofluorescence staining method to demonstrate the distribution of a blood group antigen cross reacting with human group B, and by labelling with tritiated thymidine to localize areas of cell proliferation. Within hours, blood group antigen reac... | 402,062 | [
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Experimental infection of cats with the liver fluke Platynosomum concinnum,. | The severity of Platynosomum concinnum infection in cats experimentally infected with 125 flukes (small dose) and 1,000 flukes (large dose) was determined by monitoring clinical signs and hematologic, serum biochemical, and pathologic changes during the infection. All cats (8/8) with a small fluke burden and 3 of 8 cat... | 402,094 | [
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Persistence of Mycobacterium tuberculosis in sputum without chest roentgenographic evidence of active disease. | Mycobacterium tuberculosis has been isolated consistently from sputum over an 11-year period in an asymptomatic 64-year-old man whose chest radiographs show evidence of healed primary tuberculosis (Ranke complex) but no evidence of parenchymal disease. A lymph node-bronchial fistula associated with the Ranke complex is... | 402,095 | [
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Vitiliginous achromia with malignant melanoma. Tyrosinase activity and ultrastructural study of achromic and normal skin. | Vitiliginous achromia with malignant melanoma shows some discrepancies with vitiligo. In both achromic and normal skin, four bands A, B, C, D of tyrosinase activity are observed; in vitiligo only bands A and B appear. Ultrastructural findings in achromic skin are similar in both conditions. But in achromia with maligna... | 402,121 | [
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Envelope glycoproteins of Rauscher murine leukemia virus: isolation and chemical characterization. | The envelope glycoproteins (designated gp70 and gp45) of the Rauscher strain of murine leukemia virus were solubilized by osmotic shock and freeze-thawing in chaotropic solutions. The viral glycoproteins were then purified by phosphocellulose chromatography and gel permeation chromatography on Bio-Gel A-1.5m. Yields by... | 402,147 | [
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Preparation and characterization of total, rough and smooth microsomes from the lung of control and methylcholanthrene-treated rats. | Optimal conditions for the preparation of relatively pure microsomes and microsomal subfractions from rat lung have been determined. The most importnat of these conditions is homogenization of a 20% (w/v) suspension of lung tissue in 0.44 M sucrose/1% (w/v) bovine serum albumin with four up-and-down strokes at 440 rev.... | 402,160 | [
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Isolated thyrotropin deficiency due to a pituitary tumour. | Hypothyroidism due to isolated deficiency of thyrotropin (TSH) associated with an enlarged sella turcica, presumably the result of a nonfunctioning pituitary adenoma, occurred in a 58-year-old man. Low serum concentrations of TSH and thyroid hormones, together with the lack of TSH response to administration of thyroid ... | 402,180 | [
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Comparison of vascular smooth muscle cells from adult human, monkey and rabbit in primary culture and in subculture. | A method is presented for growing large numbers of pure isolated smooth muscle cells from adult human, monkey, and rabbit blood vessels in primary culture. In the first few days in culture these cells closely resembled those in vivo and could be induced to contract with angiotensin II, noradrenaline and mechanical stim... | 402,216 | [
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[Protein synthesis in vivo in muscles of the growing lamb]. | The relationship between incorporation of intravenously injected 14C lysine and specific radio-activity of precursor was used to estimate protein synthesis in muscle of growing lambs. The rate of protein synthesis per unit of muscle weight in Supraspinatus and Extensor digitorum longus decreased strongly from one week ... | 402,227 | [
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The role of sulfhydryl groups in the binding of glucocorticoids by cytoplasmic receptors of lung and other mammalian tissues. | We examined the levels and stability of glucocorticoid receptor activity in cytosol preparations of rat lung and other tissues. [3H]Dexamethasome binding capacity at 2 C in lung cytosol decreases with a t1/2 of 40 min in the absence of steroid or a sulfhydryl compound. This rapid inactivation of unbound receptor is pre... | 402,260 | [
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... |
Hypoxia-induced metabolic and core temperature changes in the squirrel monkey. | To identify components of reduced core temperature (Tre) with exposure to hypoxia, oxygen uptake (VO2) and skin temperatures were measured in chair-restrained squirrel monkeys during conditions of 21% O2, 11% O2, and 11% O2 + 5% CO2. Exposure to 11% O2 resulted in a 20% decrease in VO2 and a 1.8 degrees C reduction of ... | 402,348 | [
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Biochemical properties of Clostridium bifermentans spores. | As previously found for spores of Bacillus species, dormant spores of Clostridium bifermentans contained essentially no adenosine triphosphate, a high level of adenosine monophosphate, a high level of 3-phosphoglyceric acid, and much transfer ribonucleic acid lacking a 3'-terminal adenosine monophosphate residue. As in... | 402,349 | [
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Some properties of a membrane-deoxyribonucleic acid complex isolated from Bacillus subtilis. | Membrane-deoxyribonucleic acid (DNA) complexes were isolated from Bacillus subtilis by affinity for magnesium-Sarkosyl crystals. These complexes (M-bands) contained greater than 80% of the total cellular DNA; little of the remaining portion could be recovered in a secondary isolation. Isotopic labeling of the origin of... | 402,358 | [
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Serum levels of thyrotropin, thyroid hormones and their response to thyrotropin releasing hormone in infective febrile illnesses. | In 25 patients suffering from fever of infection, serum levels of thyrotropin (TSH), thyroxine (T4), triiodothyronine (T3), and thyroxine binding globulin (TBG) were estimated on two consecutive days during the febrile period and again 3 to 10 days after the fever had subsided. The serum TSH and T3 responses to 100 mug... | 402,380 | [
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The antepartum findings of conjoined twins. | Various estimates abound as to the incidence of conjoined (Siamese) twins, but they are indeed uncommon. The probability of their occurance has been calculated to be once in every 12,000 to once in every 100,000 deliveries. Although uncommon, the antepartum diagnosis can be extremely important to the twins and the moth... | 402,393 | [
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Economics, management, and public health nutrition. | Research has shown that including a nutritional functional area in comprehensive health care delivery can reduce the total cost per registrant. The savings occur when nutritionists substitute for more costly medical personnel in a team-care setting. Further research has demonstrated that the cost of nutritional care is... | 402,409 | [
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Histaminase release from human eosinophils. | Phagocytosis of opsonized zymosan by human eosinophils results in a dose-dependent noncytotoxic release of histaminase as well as arylsulfatase and beta-glucuronidase. The calcium ionophore A23187 also stimulates release of eosinophil histaminase at concentrations of ionophore which barely release arylsulfatase and bet... | 402,420 | [
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Focal epithelial hyperplasia in a group of south africans: Its clinical and microscopic features. | Thirty-seven cases of focal epithelial hyperplasia were discovered among pupils of reform schools and none among pupils of ordinary schools. This difference in occurrence was significant (P less than 0.01). Lesions were either discrete papules or clusters of papules; and the lining mucosa was the most affected part. Ei... | 402,448 | [
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Potent inhibitory effect of a new antiestrogen (RU 16117) on the growth of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors. | At the daily dose of 24 mug for a period of 4 weeks, RU 16117 (11alpha-methoxyethinyl estradiol), a new antiestrogen, led to 65% reduction of the number of already established dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in female Sprague-Dawley rats. Not only the tumor number but also the tumor size was red... | 402,479 | [
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The establishment of specified-pathogen-free marmosets, Callithrix jacchus. | The establishment of 3 specified-pathogen-free marmosets (Callithrix jacchus) during the period May 1969 to January 1973 is described. A brief history of the conventional breeding colony from which the animals were derived is given and hysterotomy and hand-rearing techniques are described. | 402,500 | [
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Influence of intravenous nutrients on bilirubin transport. III. Emulsified fat infusion. | Infusions and injections of Intralipid were administered to congenitally jaundiced rats (Gunn) in whom the total body bilirubin pool was uniformly labeled with radioactive bilirubin. These isotopic studies indicated that Intralipid treatment had no effect on the kinetics of bilirubin formation, transport, tissue distri... | 402,631 | [
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Computerized axial tomography in neurologic disorders of children. | Computerized axial tomography offers major advantages over air encephalography and angiography for studies of neurologic disorders in children. The low morbidity and the ease of the procedure permit the accurate diagnosis of intracranial pathology in situations where more invasive procedures would not be undertaken. Th... | 402,634 | [
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Penicillin V therapy for streptococcal pharyngitis: comparison of dosage schedules. | Two dosage regimens of penicillin V were compared in 327 patients with mild to moderately severe streptococcal pharyngitis. Patients fulfilling study criteria were randomly assigned to a b.i.d. or a t.i.d. dosage schedule. Those in the b.i.d. group were given 500 mg twice daily; those in the t.i.d. group were given 250... | 402,697 | [
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Teratogenic effects of retinoic acid in pigtail monkeys (Macaca nemestrina). I. General features. | Daily oral administration of 10 mg/kg retinoic acid to pregnant Macaca nemestrina monkeys on days 20 to 44 resulted in a high frequency of craniofacial and musculoskeletal malformations. Craniofacial defects including cleft palate and anomalies of the prinna were common as were ectrodactyly, kyphosis, and muscular-join... | 402,705 | [
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Lipid pigment formation in cultures of chick hepatocytes. Effects of aging and of oxidizable agents. | Tissue cultures of hepatocytes were studied for the formation of lipid pigments as related to aging of the cultures and of the addition to them of: 1) colloidal iron; 2) L-ascorbic acid; and 3) tyrosine. The presence of lipid pigments was gauged by their sudanophilia after a light solvent extraction and yellow autofluo... | 402,736 | [
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Tetraploid cell line in a girl with acute leukaemia. | In a girl with atypical acute leukaemia the malignant cell line in peripheral blood and bone marrow during these relapses was found to be tetraploid. The abnormal cells were more proliferative than those usually present in acute leukaemia. The tetraploid DNA content of the blast cells distinguished them from other cell... | 402,763 | [
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The effects of discontinuing long-term diuretic therapy in the elderly. | The effects of discontinuing long-term diuretic therapy were investigated by means of a double-blind randomized controlled trial. A total of 141 elderly patients in the long-stay wards of six hospitals were found to be taking maintenance diuretics, and for 33 of these the drugs were judged to be mandatory. Of the remai... | 402,800 | [
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Characteristics of response of isolated smooth muscle cells to cholinergic drugs. | The contractile responses of suspensions of isolated smooth muscle cells from the stomach muscularis of Bufo marinus were assessed with a Coulter counter. Contractile responses of strips from the same tissue were recorded isotonically. Suspensions of isolated smooth muscle cells exhibit a dose-dependent graded response... | 402,821 | [
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Bicarbonate ions in active sodium transport across toad bladder. | The conductance, ga, and electromotive force, E, of active ion transport across toad bladders mounted as sacs were estimated from electrical measurements made before and after addition of sufficient ouabain (1.89 X 10(-3) M) to eliminate spontaneous potential. The ratio of net sodium transport (estimated from bidirecti... | 402,825 | [
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A new simple power injector. | A new simple pneumatic-hydraulic injection device has been constructed, tested, and used in clinical angiography. Is is the only injector which produces a square wave velocity curve with immediate rise time. Disposable plastic syringes are used which convert the velocity profile of the plunger into a smooth buildup tim... | 402,830 | [
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... |
Mechanisms of CO2 fixation in bacterial photosynthesis studied by the carbon isotope fractionation technique. | The carbon isotope discrimination properties of a representative of each of the three types of photosynthetic bacteria Chlorobium thiosulfatophilum, Rhodospirillum rubrum and Chromatium and of the C3-alga Chlamydomonas reinhardii were determined by measuring the ratio of 13CO2 to 12CO2 incorporated during photoautotrop... | 402,896 | [
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Transcription and translation of cloned Drosophila DNA fragments in Escherichia coli. | The expression of three unique DNA fragments from Drosophila melanogaster which have been inserted into Escherichia coli (E. coli) via the plasmid, pSC 101, was studied. The hybrid plasmid DNA molecules containing Drosophila DNA were transformed into the minicell producing strain of E. coli, X1411. Drosophila DNA-direc... | 402,934 | [
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Purification, properties, and partial structure elucidation of a high-molecular-weight glycoprotein from cervical mucus of the bonnet monkey (Macaca radiata). | A high-molecular-weight glycoprotein has been purified from the cervical mucus of the bonnet monkey (Macaca radiata). The glycoprotein was shown to be homogeneous by electrophoresis, sedimentation equilibrium, and N-terminal group determination, and to contain 19% protein, 19% D-galactose, 18% N-acetyl-D-galactosamine,... | 402,940 | [
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Gamma heavy chain disease: clinical aspects and characterization of a deleted, noncovalently linked gamma1 heavy chain dimer (BAZ). | This report describes the clinical and immunoglobulin features of a patient with gamma heavy chain disease (HCD), who presented with a clinical picture suggestive of an underlying malignancy rather than the usual picture of lymphoma or granulomatous disease. A unique clinical feature was the nearly total replacement of... | 402,960 | [
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Treatment tolerance and early complications with extended field irradiation in gynaecological cancer. | Treatment tolerance and early complications have been analysed in patients treated with extended field irradiation and pelvic irradiation alone. At the Centre Georges-François Leclerc, 126 patients were treated for carcinoma of the uterine cervix and endometrium from May, 1972 to November, 1974. All patients received e... | 402,972 | [
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0.0438954... |
Scanning electron microscopical examination of gonococcal urethral exudate. | The relationship of gonococci and phagocytes in gonococcal urethral exudate was examined using a scanning electron microscope. Several stages in the phagocytic process were evident. These included pseudopodias, microvilli, and simple attachment of gonococci to phagocytic surfaces. Epithelial cells, also a part of the e... | 402,977 | [
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0.05607515... |
Ethane-1-hydroxy-1, 1-diphosphonate (EHDP) effects on incorporation and accumulation of osteoclast nuclei. | Male rats weighing 100 g were injected with vehicle (control group), 0.4 or 4.0 mg/kg/day of ethane-1-hydroxy-1,1-diphosphonate (EHDP). Beginning after 6 days of EHDP treatment all rats received six subcutaneous injections of 3H-thymidine at 8 h intervals. The multiple labeling index of autoradiographically defined lab... | 402,991 | [
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On the inhibition of microsomal drug metabolism by polychlorinated biphenyls (PCB) and related phenolic compounds. | The in vitro metabolism of p-nitroanisole, aminopyrine, and aniline by rat liver microsomal monoxygenases were studied in the presence of different polychlorinated biphenyl (PCB) mixtures and some related hydroxybiphenyls. The tested PCB mixtures contained preferably dichloro- (di-CB), tetrachloro- (tetra-CB), or hexac... | 403,020 | [
-0.3162889,
0.5745974,
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-0.2788652,
0.1379081,
0.0103526,
-0.4708373,
0.2764162,
-0.1069641,
0.1142023,
0.1986601,
0.3755214,
0.004907808,
0.1761775,
-0.5112393,
-0.2546966,
-0.6339086,
0.5686677,
-0.06853288,
0.1696914,
0.07931046,
0.3645226,
-0.06922159,
-0... |
Nosological problems of myoclonic epilepsies in childhood and adolescence. | An attempt is made to clarify the confusion over the classification of the myoclonic epilepsies of childhood. Six types of seizure are described, the classification being based on clinical and electroencephalographic findings. The types of myoclonic epilepsy are infantile spasms, myoclonic astatic epilepsy, myoclonic a... | 403,103 | [
-0.1928869,
0.008899288,
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-0.3089355,
0.3155456,
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0.5028281,
0.3327576,
-0.2058827,
0.2488523,
-0.07564348,
-0.1017578,
... |
Neonatal-maternal weight relationship in macaques: an example of intrageneric scaling. | In the genus Macaca, represented by seven species, neonatal weight scales at a power of maternal weight of a = 0.49. This value is lower than those for subordinal and ordinal scaling of neonatal weight in primates (a = 0.63-0.78), but it is higher than the value for intrageneric scaling of brain weight in Macaca (a = 0... | 403,112 | [
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0.1090343,
0.1482307,
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-0.1520047,
0.1425436,
-0.0725817... |
[Starvation and surgical intervention]. | The metabolic processes under conditions of stress and starvation are not identical. Moreover, they have to be differentiated, as far as carbohydrate-, fat- and amino-acid-metabolism are concerned, because both situations are not compatible. It is therefore required, to avoid any kind of starvation and particularly to ... | 403,132 | [
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0.1576741,
0.1753893,
-0.03504495,
-0.09797... |
Purification of a monocytosis-producing activity from Listeria monocytogenes. | The monocytosis-producing activity (MPA) from Listeria monocytogenes is shown to be associated with the cell envelope. Both MPA and immunosuppressive activity were readily extracted with aqueous solvents and separated as two independent activities by gel filtration and ion-exchange chromatography. As little as 10 micro... | 403,137 | [
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0.07723958,
0.1470606,
0.3979907,
0.38811,
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0.00773575,... |
Genital inoculation of male baboons with Neisseria gonorrhoeae. | Eight male baboons inoculated intraurethrally with Neisseria gonorrhoeae failed to shed gonococci or develop serum antibody. Urethral inoculation, preceded by epididymal inoculation, elicited an anamnestic antibody response. | 403,145 | [
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0.04109391,
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0.3078348,
0.1820497,
0.073905... |
Vulnerability of specific rat chromosomes to in vitro chemically induced damage. | The treatment of rat embryo secondary cultures with DMBA or DMBA-3H for 5, 9, or 24 h resulted in chromosome damage consisting mainly of chromatid type aberrations. There was an increase in the percentage of labelled nuclei and metaphases with increasing length of exposure. In terms of incidence of chromatid lesions, t... | 403,147 | [
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0.1290548,
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0.4819503,
0.3644219,
-0.08013073,
... |
Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rat lens. | Aldose reductase (AR) and sorbitol dehydrogenase (SDH) make up the sorbitol pathway, which has been implicated in the pathogenesis of sugar cataracts. The levels of the two enzymes were determined with quantitative histochemical techniques in the epithelium, cortex, and nucleus of normal and diabetic rat lenses. The ra... | 403,152 | [
0.1607203,
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0.2214332,
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0.3326651,
0.247598,
0.002702048,
0.3028602,
0.3065288,
0.2304709,
-0.0498... |
Isolation and preliminary characterization of auxotrophs of a filamentous Cyanobacterium. | Auxotrophic mutants of the filamentous cyanobacterium Anabaena variabilis were isolated by a method in which, after mutagenesis and before penicllin enrichment, mutant and wild-type cells were separated by cavitation. Auxotrophs were identified by their inability to grow on minimal medium, and they were partially chara... | 403,180 | [
-0.06602431,
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0.4491691,
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0.09847984,
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0.1313813,
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0.2196732,
-0.2316868,
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0.01616638,
0.09118903,
0.5271701,
0.2879119,
-0.0115028... |
Dependence of calcium permeability of sarcoplasmic reticulum vesicles on external and internal calcium ion concentrations. | The ability of sarcoplasmic reticulum vesicles to retain calcium following ATP-supported calcium uptake in the presence of the calcium-precipitating anions oxalate and phosphate depends on Cao (calcium ion concentration outside the vesicles) and Cai (calcium ion concentration within the vesicles). Calcium efflux rates ... | 403,187 | [
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0.3182636,
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0.1277973,
0.2167303,
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-0.1062256,
-0.007920804,
0.3704435,
0.01655883,
-0.0... |
Complement-fixing antibody response to rotavirus infection. | A human rotavirus complement-fixing (CF) antigen, prepared by purification of large volumes of fluid feces collected from children with winter diarrhea, was used to study the development and persistence of antibody in children with diarrhea and the prevalence of rotavirus antibody in Melbourne. In children with diarrhe... | 403,196 | [
-0.153713,
0.002653448,
-0.07314353,
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0.122254,
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0.08873172,
0.1283292,
0.0354249,
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0.1345977,
0.0259898,
0.1898975,
0.01457932,
-0.009950631,
-0.2938103,
-0... |
Murine and rat IgE: relationships in terms of binding to cell receptors and to antibodies against rat epsilon chain. | The similarity between murine and rat IgE was examined in terms of their fixation to target cells and interaction with monospecific antibodies to rat epsilon-chain (anti-epsilon). Purified rat monoclonal IgE (IgEr) was found to block the fixation of murine reagin (IgEm) to mouse and rat skin and to rat basophilic leuke... | 403,236 | [
0.3481514,
-0.2009994,
0.1303295,
-0.008108798,
0.2547615,
0.02829916,
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0.2052223,
0.1245788,
0.3770066,
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0.5153146,
0.04775555,
0.3366953,
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-0.1264499,
-0.1566822,
-0.1485338,
0.155417,
-0.003837356,
-0.0550858,
-0.0983154... |
Treatment of mixed bacterial infections with clindamycin and gentamicin. | Thirty-eight patients with severe mixed bacterial infections were treated with clindamycin and gentamicin. In vitro, all staphylococci and streptococci (other than enterococci) and 96% of anaerobes were susceptible to clindamycin; all staphylococci and 92% of Enterobacteriaceae and Pseudomonas aeruginosa were susceptib... | 403,243 | [
0.05862331,
-0.03395567,
-0.104571,
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-0.1278569,
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-0.08948763,
-0.01915329,
0.2201455,
0.3423251,
-0.1326556,
0.2829... |
L-Dopa peroxidase activity of human erythrocyte catalase. | The human red cell hemolysate was found to have 3-(3',4'-dihydroxphenyl)-L-alanine (L-dopa) peroxidase activity. During the purification of glutathione peroxidase and catalase by ammonium sulfate precipitation, ion exchange chromatography. Sephadex gel filtration, and preparative polyacrylamide disc electrophoresis, th... | 403,244 | [
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0.1762629,
-0.3052807,
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-0.1701045,
-0.02546838,
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0.01810293,
0.1553051,
0.2240011,
-0.05716684,
0.1521529,
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0.2738065,
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-0.04314862,
0.1107767,
0.2027773,
0.250759,
0.1030124,
-0.1215018,
0.... |
A rapid radiometric method for determining the sensitivity of clinical isolates of Mycobacterium tuberculosis to several chemotherapeutic agents. | Current methods of performing antibiotic susceptibility tests on M. tuberculosis require 4 to 6 weeks for completion and in some cases have a poor correlation with clinical results. We have developed a rapid radiometric method of sensitivity testing which utilizes the incorporation of 3H-uracil into ribonucleic acid (R... | 403,245 | [
0.06349494,
0.0597162,
0.03571938,
-0.1690184,
-0.01714083,
-0.1876601,
-0.4535125,
0.1682197,
0.3971097,
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0.1597279,
0.09408526,
0.05890309,
0.499748,
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0.2387751,
-0.4353463,
0.2814706,
0.4134822,
-0.4143095,
0.1412194,
0... |
Properties and tectal projections of monkey retinal ganglion cells. | 1. Extracellular single-unit recordings were undertaken in the retina of the rhesus monkey in order to assess the receptive-field properties of those ganglion cells which project to the superior colliculus. Cells were tested for antidromic activation from the superior colliculus, lateral geniculate nucleus, and the opt... | 403,252 | [
0.3840291,
-0.04204769,
-0.3896847,
-0.2337881,
-0.04548001,
-0.5149822,
0.02788052,
0.04622109,
0.03740145,
0.0584468,
0.06691337,
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0.036601,
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0.2880196,
0.04539176,
-0.1397934,
0.0333944,
0.3269256,
0.3100253,
... |
Release of antidiuretic hormone during mass-induced elevation of intracranial pressure. | There are complex osmotic and non-osmotic factors regulating release of antidiuretic hormone (ADH). A wide variety of intracranial pathological processes may trigger ADH release sufficient to produce clinically recognizable hyponatremia, or the "inappropriate ADH syndrome." We systematically studied one non-osmotic tr... | 403,253 | [
-0.6375076,
0.07072224,
-0.08846121,
-0.02832034,
0.2434798,
-0.2158412,
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0.07668681,
0.08646853,
0.2061479,
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0.01931407,
0.1269696,
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-0.1270805,
0.1808818,
-0.3209307,
0.01129697,... |
Effects of morphine, methadone, nalorphine and naloxone on responding under schedules of electric shock titration. | Under two titration schedules, responses of squirrel monkeys adjusted the intensity of a continuous electric shock. In one schedule, responses produced food pellets but also increased a shock intensity which otherwise was decreased at a fixed rate (punishment titration). In another schedule, responses decreased a shock... | 403,279 | [
-0.03987679,
0.2550899,
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0.08838616,
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0.05460221,
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0.05895375,
0.3175209,
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-0.3676019,
0.09557242,
-0.06126748,
0.140669,
0.07133979,
-0.526461,
0.1808529,... |
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