title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Percentiles as reference values for laboratory data. | It has been suggested that laboratory results be reported, not only in conventional units, but also in terms of equivalent percentiles from a reference population. This would afford the clinician an easily interpretable measure of how unusual such a result would be in the reference population. This paper describes a mo... | 453,116 | [
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Dye clearance studies in Rotor's syndrome. | Plasma clearances of sulfobromophthalein sodium (BSP), indocyanine green (ICG) and unconjugated bilirubin were studied in six patients with Rotor's syndrome. A marked retention of these three substances in the plasma was observed. At 60 minutes after injection, serum BSP consisted almost entirely of the unconjugated fo... | 453,129 | [
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Fiberendoscopic removal of long foreign bodies from the stomach using a colon stiffening tube as a protective sheath. | A colonoscopic stiffening tube was effectively used as a protective sheath in the esophagus during the endoscopic removal of a long ballpoint pen and a writing pencil from the stomach. | 453,146 | [
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Malignant carcinoid of the appendix: case report with radiographic and angiographic demonstration. | An unusual case of a malignant carcinoid of the appendix is reported, together with a brief review of the pertinent literature. The case exhibited mesenteric invasion, peritoneal seeding, terminal ileal ischemia and features of the carcinoid syndrome. The radiographic and angiographic documentation are unique in the li... | 453,164 | [
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Electrical wiring configurations and childhood cancer. | An excess of electrical wiring configurations suggestive of high current-flow was noted in Colorado in 1976--1977 near the homes of children who developed cancer, as compared to the homes of control children. The finding was strongest for children who had spent their entire lives at the same address, and it appeared to... | 453,167 | [
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Urinary tract endometriosis: enigmas in diagnosis and management. | The diagnosis and management of endometriosis presents several enigmas. This review, of eight patients with endometriosis involving the urinary tract, from three large clinical services in the City of Los Angeles, highlights some very difficult problems. Not only diagnostic errors but also inappropriate conservatism an... | 453,243 | [
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Office termination of pregnancy by "menstrual aspiration". | A program of office menstrual aspiration was initiated in our institution in 1972. Since that time 1,443 patients have been admitted into the study. These patients were evaluated by age, marital status, gravidity, repeat pregnancy terminations, complications, and detailed tissue analysis as well as contraception utiliz... | 453,250 | [
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13, 14-dihydro-15-keto-prostaglandin F2alpha concentrations in human plasma and amniotic fluid. | An antiserum to 13,14-dihydro-15-keto-prostaglandin F2alpha (PGF2alphaM) was prepared and a radioimmunoassay evaluated in various reproductive states. PGF2alphaM plasma concentration was 63.6 +/- 10.3 pg/ml (mean +/- SEM) in cycling women. The concentration fluctuated throughout the menstrual cycle and pregnancy, but n... | 453,260 | [
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Stage I squamous cell cancer of the vulva. | A review of 106 patients with Stage I squamous cell cancer of the vulva treated at the Mayo Clinic from 1950 through 1975 is presented. Microinvasive lesions (5 mm penetration or less) were present in 96 patients (91%); invasive lesions (more than 5 mm penetration) were diagnosed in 10 (9%). Inguinal node involvement w... | 453,281 | [
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Antepartum fetal testing. I. The oxytocin challenge test. | Two hundred seventy-eight high-risk patients were managed by a comprehensive assessment of the anatomic, biochemical, and functional environment of the fetoplacental unit utilizing predetermined guidelines. Decisions to terminate pregnancy were reserved for patients who demonstrated a positive OCT. Perinatal outcome in... | 453,290 | [
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Antepartum fetal testing. II. The acceleration/constant ratio: a nonstress test. | For a period of one-half hour of undisturbed fetal monitoring, periodic changes of the FHR in response to spontaneous fetal movements (FM's) were recorded. FM's in patients who subsequently had positive OCT's were less likely to show accelerations (p = 0.001) and more likely to show variable decelerations (p = less tha... | 453,291 | [
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Fetal breathing movements in uncomplicated pregnancies. I. Relationship to gestational age. | Fetal breathing movements occur in uncomplicated gestations. The relationship of fetal breathing movements recorded in 30 min sessions to gestational age and blood glucose levels is described. A total of 142 recording sessions were obtained from 45 gravid women with uncomplicated pregnancies from 24 to 41 weeks' gestat... | 453,292 | [
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Further observations on the effect of topical progesterone on vulvar disease. | Follow-up studies have confirmed the beneficial effect of topical progesterone in the treatment of vulvar dystrophy, whether of the atrophic, hypertrophic or mixed variety, in both postmenopausal and premenarchal women. If pruritus is a major symptom, topical corticosteroids should be alternated with the progesterone p... | 453,296 | [
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Survival rates after enucleation of eyes with malignant melanoma. | We investigated the rates of mortality for several types of malignant melanomas for evidence that surgery accelerates metastasis. Additionally, we reanalyzed uveal melanoma survival rates from the Armed Forces Institute of Pathology. Our computations showed higher death rates in years two to five after diagnosis than i... | 453,304 | [
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Adrenal cortex in retired breeder Mongolian gerbils (Meriones unguiculatus) and golden hamsters (Mesocricetus auratus). | Alterations occur predominantly in cells of the zona reticularis in retired breeder Mongllian gerbils and golden hamsters. In gerbils, the size and number of lipid droplets increased and numerous large lipid-lysosomal complexes were observed in zona reticularis parenchymal cells or in macrophages, which were more numer... | 453,320 | [
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Canine granulocytopathy syndrome: an inherited disorder of leukocyte function. | A disease closely resembling the human neutrophil dysfunction syndromes has been identified in a colony of dogs. The syndrome, referred to as the canine granulocytopathy syndrome, is characterized by recurrent-life-threatening bacterial infections and a greatly shortened life span. The disease is genetically determined... | 453,331 | [
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Familial (genetic) subtypes of pure depressive disease. | The author reviewed data from five studies and found that depressed patients with a history of depression in a parent or child have more sibships containing depression than depressed patients without this family history. Thus, there is a clustering of depressions in certain families. Sporadic pure depressive disease (P... | 453,352 | [
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Evaluation of a group nutrition education approach to effective weight loss and control. | Fifty-three male officers of the Boston Police Department voluntarily participated in a 12-week nutrition program with weight control as a primary goal, and education in related health factors as a secondary goal. One year after graduation, 26 respondents to a survey reported losing an average additional 0.5 kg since g... | 453,416 | [
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Acquired resistance to ticks: expression of resistance by C4-deficient guinea pigs. | Hartley and C4-deficient guinea pigs developed resistance to the ixodid tick. Dermacentor andersoni, after one infestation. Resistance was characterized by resistant animals of both groups allowing significantly fewer larvae (5--25%) to engorge during a second infestation than during an initial infestation (70--90%). R... | 453,452 | [
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Upper limb ischemia resulting from arterial thromboembolism. | Acute ischemia of the upper limb is commonly caused by trauma and embolic arterial occlusion. However, primary atherosclerotic thrombosis is found infrequently and concern regarding its incidence, recognition, and treatment prompted a review of our clinical experience. Of 36 patients with acute ischemia of the upper li... | 453,466 | [
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Intraarterial infusion chemotherapy (5-fluorouracil) in patients with inextirpable or locally recurrent rectal cancer. | A retrospective analysis of the results of treatment of advanced rectal cancer of the pelvis with regional intraarterial infusion of 5-fluorouracil (5-FU) is reported. A special technic for positioning the catheters selectively in the internal iliac arteries justifies this analysis. Four patients with primary inextirpa... | 453,469 | [
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Treatment of postradiation stricuture of the rectum by the modified Duhamel procedure. | Benign rectosigmoid stenosis secondary to pelvic radiation presents a difficult problem in management and is usually treated by permanent colostomy with its attendant discomfort and inconvenience. Other approaches include low anterior resection or even transsacral resection of the affected area of rectosigmoid, but the... | 453,474 | [
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Plasma potassium, sodium and blood sugar following etomidate and suxamethonium. | Changes in plasma potassium, sodium and blood sugar were studied in Nigerian patients following induction of anaesthesia with etomidate and suxamethonium. Healthy patients presenting for elective surgery as well as psychiatric patients presenting for electroconvulsive therapy were studied. Plasma potasium was essential... | 453,501 | [
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Anaphylactoid response to intravenous tubocurarine. | A case of severe anaphylactoid reaction to tubocurarine in a 42-year-old female is described. This is particularly notable as there was no history of past allergies or of previous exposure to the drug. | 453,507 | [
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Lipofuscin in the cerebellar cortex of albino rats: an electron microscopic study. | The ultrastructure of autofluorescent, PAS-positive lipofuscin in Purkinje, granule, Golgi epithelial, basket and stellate, microglial and perivascular cells in the cerebellar cortex of senescent rats is described. The membrane-bounded pigment is composed of three elements: 1) electron-lucent homogeneous droplets, 2) a... | 453,548 | [
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Uterine blood flow and plasma norepinephrine changes during maternal stress in the pregnant ewe. | Because maternal stress may adversely affect the fetus, the authors tested the effects of brief episodes (15-60 sec) of maternal stress in 18 awake pregnant ewes. Maternal agitation and stuggling occurred either following non-painful stimuli such as loud noises or sudden movements of personnel (ten animals) or followin... | 453,577 | [
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Fine structure of digital vascular lesions in Raynaud's phenomenon and disease. | The ultrastructural changes in the vessels of the fingertips of patients with Raynaud's phenomenon or disease, with or without scleroderma, are described for the first time. Fingertip specimens were taken by punch biopsy. The light microscopic changes, including segmental vasculitis, fibrinoid degeneration of capillari... | 453,638 | [
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Inhaled atropine in asthma. | Ten adult asthmatics inhaled atropine and isoproterenol to determine the site of action in the airways and relative effectiveness of the two drugs. The two agents were equal in their effect on lung volumes and airway resistance but isoproterenol produced significantly better flows. Atropine was shown to be an effective... | 453,644 | [
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Quantitative effect of theophylline anhydrous on exercise-induced asthma after maximal physical effort. | The quantitative effects of theophylline anhydrous upon exercise-induced asthma (EIA) were evaluated in asthmatic children. Theophylline inhibits EIA after maximal physical effort, increases tolerance to exercise and exerts a greater inhibitory effect upon larger than smaller airways. Its inhibitory effect seems not to... | 453,655 | [
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... |
Vitamin D intoxication and the pathogenesis of vitamin D nephropathy in the dog. | Dogs given excess vitamin D (500 or 1,000 micrograms/kg of body weight each day for 1 to 3 weeks were observed for clinical and pathologic changes of increased blood pressure and of characteristic nephropathy associated with vitamin D toxicosis or hypercalcemia. Serum calcium and serum urea nitrogen (UN) increased thro... | 453,687 | [
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Correlation between the function and structure of the lung in smokers. | To study the relationship between morphologic changes and alteration of lung function, the excised lobes of 21 smokers and one nonsmoker who required lobectomy for small peripheral tumors were inflated and fixed in formalin, and measurements of bronchiolar narrowing and degree of emphysema were made. All patients had c... | 453,695 | [
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Treatment of hiatal hernia with esophagitis in a patient using esophageal speech after laryngectomy. | Severe reflux esophagitis occurring after total laryngectomy in a patient who has learned to communicate by esophageal speech represents a unique problem in management. It was anticipated that an antireflux operation might interfere with esophageal speech. A Nissen fundoplication resulted in complete resolution of sign... | 453,734 | [
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The scintillating scotoma without headache. | Scintillating scotomas are frequently seen without an associated headache and in general should be considered a benign symptom. In this series of 10 patients with an age range from 25 to 72 years, there were 7 female and 3 male patients. With an average follow-up of 1 1/2 years there was no patient who subsequently dev... | 453,755 | [
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The binocular confusion in unilateral aphakia. | The first 4 symptoms of binocular confusion concern primarily daytime vision and the fifth symptom concerns nighttime vision. Even with a conventional contact lens correction, symptoms of binocular confusion occur, especially with high optical aniseikonia for near or far distance. In addition, diplopia occurs in the pr... | 453,758 | [
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Atypical drusen in pseudoxanthoma elasticum. | Forty-three patients with pseudoxanthoma elasticum were evaluated ophthalmologically. The fundus appearance was characterized by angioid streaks and mottling of the retinal pigment epithelium. Rock-like atypical drusen were present in the posterior pole or peripheral retina in 75% of the patients examined and were an i... | 453,761 | [
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Combined thermotrabeculocanalotomy cataract extraction. | The results of combined thermotrabeculocanalotomy-cataract extraction are reported on 9 cases, 7 of which are glaucoma cases controlled by medical therapy, one secondary glaucoma following chronic angle-closure, and one secondary glaucoma following trauma. The results were satisfactory both in terms of visual acuity an... | 453,764 | [
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0.226... |
Serum immunoglobulin abnormalities in patients with respiratory tract disease. | Serum immunoglobulin concentrations in patients representing four different categories of respiratory diseases are compared with each other and with an age related group of healthy voluntees. Natural immune stimulation of the respiratory tract results in a significant rise in serum IgA and IgG but not IgM. A comparisio... | 453,780 | [
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Nervous reactivity disturbances in patients with late post-traumatic encephalic syndromes. | A polygraphic study performed on 184 patients with late post-traumatic encephalic syndromes has shown marked nervous reactivity disturbances. The disturbances, estimated by testing for the electrographic components of the orienting reflex elicited by a repetitive auditory stimulus and for their habituation, were expres... | 453,814 | [
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0.1882679... |
Metabolism of 3-chloro-, 4-chloro-, and 3,5-dichlorobenzoate by a pseudomonad. | Pseudomonas sp. WR912 was isolated by continuous enrichment in three steps with 3-chloro-, 4-chloro-, and finally 3,5-dichlorobenzoate as sole source of carbon and energy. The doubling times of the pure culture with these growth substrates were 2.6, 3.3, and 5.2 h, respectively. Stoichiometric amounts of chloride were ... | 453,823 | [
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0.06542181,
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Occurrence of Vibrio parahaemolyticus in Dutch mussels. | A study was carried out on the occurrence of Vibrio parahaemolyticus in Dutch mussels originating from the East Schelde Estuary. In a totol of 79 10-g tissue samples, 3 (3.8%) were found to contain V. parahaemolyticus. In a second survey, 6 out of 23 bags of mussels (26%) contained one or more strains of V. parahaemoly... | 453,825 | [
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0.02805129,
-... |
Lesions of swine lymph nodes as a diagnostic test to determine mycobacterial infection. | Decisions as to the disposition of swine carcasses with lesions attributable to a mycobacterial infection are based upon a lesion criterion which is used as a diagnostic test by federal meat inspectors. Using this criterion, a federal meat inspector classified 58 of 100 pigs as "passed for cooking" and the other 42 pig... | 453,840 | [
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0.1551531,
0.02333685... |
Clofazimine in the treatment of pyoderma gangrenosum. | Ten patients with pyoderma gangrenosum, seven female and three male, 25 to 94 years old, mainly with multiple lesions, have been treated with clofazimine, 100 mg three times daily. Associated disease was registered in three patients: diabetes mellitus, a previous adenocarcinoma of the colon treated by hemicolectomy, an... | 453,894 | [
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... |
Nail plate-nail bed separation. An unusual side effect of systemic fluorouracil administration. | A 62-year-old woman with metastatic gastric carcinoma was treated with fluorouracil for her malignant neoplasm. Nail plate-nail bed separation was noted in the fingers and toes after two months of weekly chemotherapy and appeared to be caused by the fluorouracil. | 453,896 | [
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Erythema chronicum migrans with purpura and polymorphonuclear infiltrates. | Erythema chronicum migrans with an intensely purpuric border developed in a 70-year-old woman. A biopsy specimen, in addition to showing the usual perivascular mononuclear infiltrate, demonstrated numerous polymorphonuclear leukocytes associated with leukocytoclasis. Immunofluorescence study showed vascular deposition ... | 453,901 | [
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Palmar-plantar lichen sclerosus et atrophicus. | A 57-year-old woman has had lichen sclerosus et atrophicus confined to the palms and soles for the past six years. Diagnosis was confirmed by histologic study. Our patient's disease has been resistant to therapy. | 453,905 | [
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... |
Factors influencing better results in operation for postinfarction ventricular aneurysms. | A series of 66 consecutive patients operated on for postinfarction ventricular aneurysm is reviewed with regard to the factors influencing the progressive decline of mortality (3.2% in the last 31 patients seen). The method of myocardial protection has a significant influence on mortality, which was 45% in patients ope... | 454,018 | [
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0.191... |
The use of prostaglandin E1 and Blalock-Taussig shunts in neonates with cyanotic congenital heart disease. | Six unselected neonates with cyanotic congenital heart disease and life-threatening degrees of arterial oxygen desaturation have been managed by a protocol that includes administration of prostaglandin E1 (PGE1) and early Blalock-Taussig shunting. In 5 patients (seven paired observations) partial pressure of arterial o... | 454,028 | [
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0.2670148,
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0.2722979,
0.1209135,... |
Myocardial rupture: III. Chamber pressure, rate of distention, and ventricular disruption in isolated hearts. | We have developed an in vitro technique for producing myocardial rupture in lamb hearts, which relates tensile strength to a variety of conditions which can prevail in normal and infarcted human hearts. Retrograde perfusion of saline solution and inflation of the left ventricle was used to apply progressive stress to t... | 454,033 | [
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Calcific stenosis of the porcine heterograft. | We have encountered two cases of late calcification of the porcine heterograft. A patient in chronic renal failure died of sepsis and endocarditis fifteen months after replacement of the mitral and tricuspid valves. At postmortem examination, both heterograft valves exhibited severe calcification and thrombosis. A seco... | 454,040 | [
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Surgical management of lung bud anomalies: lobar emphysema, bronchogenic cyst, cystic adenomatoid malformation, and intralobar pulmonary sequestration. | Recently we saw 9 infants with life-threatening respiratory distress. Four patients had bronchogenic cyst, 2 had cystic adenomatoid malformation, and 9 had congenital lobar emphysema. Another group of 14 older children had recurrent infection and hemodynamic abnormalities, which responded to operative intervention. Eac... | 454,042 | [
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Muscular hypertonia: quantitative analysis. | By a statistical method of analysis, the force applied to move a limb passively can be translated into physiologically relevant parameters relating to the muscle. The parameters identified and measured are the dynamic and static activity of the muscle and their interactions with the varying length of the muscle during ... | 454,113 | [
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... |
Doppler ultrasonography for detection of deep vein thrombosis in lower extremities. | Doppler ultrasonography, a rapid, noninvasive and portable technique, has been available to clinicians for more than 10 years, but its accuracy in detecting deep vein thrombosis (DVT) has been questioned. A consistent and detailed method for testing venous circulation in the lower extremities is described. This method ... | 454,121 | [
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[The frequency of adult anticonvulsant osteomalacia in relation to duration of therapy and dosage of anticonvulsants (author's transl)]. | Of 837 epileptics over 16 years of age treated with mono- or combined hydantoin therapy 20.3% showed radiographic signs of anticonvulsant osteomalacia. With the exception of the patients with severe disturbances of the skeletal system no positive correlation was found with duration of therapy. The percentage of moderat... | 454,143 | [
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[Control mechanisms of aphasic patients in verbal and phonemic paraphasias (author's transl)]. | In the current literature on aphasia, two explanations of paraphasic errors are suggested: one is based on the idea of conscious verbal substitutions, and the other on that of uncontrolled faults in production. The purpose of this study was to relate both explanations to a) the usual classification of verbal and phonem... | 454,146 | [
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-... |
Avoiding renal vein entry when implanting the Mobin-Uddin vena cava umbrella filter. | Transvenous placement of a Mobin-Uddin vena cava umbrella filter is a safe and effective method of vena cava interruption in high-risk patients who cannot undergo laparotomy. When the renal veins enter the vena cava acutely, there may be preferential passage of the filter insertion device into the aberrant renal veins.... | 454,164 | [
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0.06827203... |
Reduction of deep sepsis after total hip arthroplasty. | The role of the operating room environment in the development of deep sepsis after total hip arthroplasty was studied at four centers. The incidence of deep sepsis after 5,865 total hip arthroplasties performed in the four centers varied from 0.5% to 2.3%. Procedures performed in a conventional operating room were asso... | 454,174 | [
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0.... |
Nonoperative internal drainage of obstructive common bile ducts. | A new nonoperative method for internal drainage of common bile duct obstructions by endoscopic retrograde cannulation of the papilla of Vater is described. After introduction of a tube in the common bile duct, a substantial decrease in serum activity of bilirubin, alkaline phosphatase, and gamma-glutamyl transferase wa... | 454,181 | [
-0.2111709,
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0.01087738,... |
[Epithelial permeability study of the bronchi in chronic bronchitis using an electron-dense tag]. | An electron dense tracer, horseradish peroxidase (HRP), treated with DAB-H2O2 for electron histochemical demonstration of peroxidase was used in an effort to find out whether or not the human bronchial epithelium was permeable to some macromolecules in chronic bronchitis. The biopsy specimens obtained from 5 patients a... | 454,230 | [
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0.04604298,
0.05728453... |
Cryopexy treatment of proliferative diabetic retinopathy. Retinal cryoablation in patients with severe vitreous hemorrhage. | Severe diabetic retinopathy with neovascular proliferation may produce severe vitreous hemorrhage that prevents laser therapy. Retinal ablation, if indicated, can be partly accomplished by cryopexy. In a small series of cases, cryotherapy to the retina was not apparently harmful and sometimes seemed beneficial. Blood a... | 454,262 | [
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0.1880286,
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Choroidal blood flow. IV. effect of vasodilating agents. | The effect of vasodilators on choroidal blood flow (CBF) was studied by the krypton clathrate Kr 85 desaturation technique in anesthetized cats. Niacin, papaverine hydrochloride, phentolamine mesylate, and tolazoline hydrochloride were injected via the lateral long posterior ciliary artery (LLPCA) and the femoral arter... | 454,273 | [
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0... |
Angiography and embolization of the internal maxillary artery for posterior epistaxis. | Epistaxis that originates from the posterior aspect of the nasal cavity is most often due to hemorrhage from one of the branches of the internal maxillary artery. There are multiple methods of treatment of this problem that vary in effectiveness, complexity, and stress on the patient. Most cases are controlled with eit... | 454,285 | [
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0.2036451,
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... |
Cystic fibrosis and hearing loss. | The mucosal epithelium of the middle ear and Eustachian tube is in direct continuity with the upper respiratory tract. Since the otolaryngological aspects of cystic fibrosis (CF) are dominated by involvement of the paranasal sinuses, it might be assumed that children with CF would be expected to have a higher than usua... | 454,286 | [
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0.03750493,
0.1784272,
... |
Glucagon and esophageal meat impaction. | Glucagon is suggested as an alternate method of treatment in difficult cases of esophageal meat impaction. Glucagon has been used in diagnostic roentgenology to facilitate smooth muscle relaxation. We describe its characteristics and mode of action, and we report two cases that emphasize the advantages of glucagon ther... | 454,294 | [
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0.249589,
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Binaural interaction in brainstem-evoked responses. | Binaural interaction (BI) in brainstem-auditory-evoked responses (BSERs) was defined as any deviation from the predictions of a model that assumes two independent monaural BSER generators whose outputs are additive. Brainstem-auditory-evoked responses were recorded in response to right (R) monaural, left (L) monaural, ... | 454,297 | [
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0.1238315,
-... |
Facial nerve repair with tissue adhesive. | The facial nerve in dogs was exposed, transected, and repaired by either of two methods. Suture and a Silastic sheath was the control method, since a review of the literature suggests it gives the highest rate of success. A tissue adhesive (Histoacryl) was used as the experimental method. In both techniques, the surgic... | 454,300 | [
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0.03... |
Regulation of mammalian protein synthesis in vivo. Simulated transport of nuclear ribonucleoprotein complexes to the cytoplasm after cycloheximide treatment. | By studies in vivo with purified nuclei from rat liver, it was shown that a non-lethal dose of cycloheximide causes a decrease in the content of total nuclear ribonucleoprotein complexes by 2h after treatment. Analysis of the complex by sucrose-density-gradient centrifugation substantiated this observation for the fast... | 454,372 | [
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Polyprenyl phosphate sugars synthesized during slime-polysaccharide production by membranes of the root-cap cells of maize (Zea mays). | Two types of experiments were carried out; either maize roots were incubated in L-[1-3H]fucose or membranes were prepared from root tips and these were incubated with GDP-L-[U-14C]fucose or UDP-D-[U-4C]glucose. The radioactively labelled lipids that were synthesized in vivo and in vitro were extracted and separated int... | 454,374 | [
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Cardiac involvement in rheumatoid arthritis. Followup study. | Initial studies from Bowman Gray School of Medicine showed that 18 of 30 patients with classic rheumatoid arthritis (RA) had cardiac involvement from their disease. These abnormalities were detected by echocardiography and consisted of mitral valve and/or pericardial abnormalities. All patients were followed for 4 year... | 454,495 | [
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0.08741912,
0.00948429... |
Plasmapheresis and lymphoplasmapheresis in the management of rheumatoid arthritis. | We have demonstrated the efficacy of therapeutic pheresis in a number of rheumatic diseases, especially rheumatoid arthritis (RA). Ten of 12 patients with RA went into remissions averaging 4 months. These patients were pheresed 20 times over 11 weeks in a tapering fashion on a Haemonetics Model 30 Blood Processor. Clin... | 454,499 | [
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... |
Effect of acute metabolic acidemia on renal electrolyte transport in man. | The effect of acute NH4C1-induced metabolic acidemia on renal electrolyte excretion was examined in nine healthy subjects during steady state water diuresis. Following oral NH4C1, venous pH and bicarbonate concentration declined significantly (p less than 0.01) while inulin and PAH clearances remained unchanged. Mean s... | 454,520 | [
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Participant evaluation of two alcohol education courses. | Two types of alcohol education courses were evaluated positively by drinking drivers (n = 40). A controlled drinking course appeared to be of greater personal relevance to participants than did the traditional education course. | 454,523 | [
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... |
Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat. | Antioxidants were found to inhibit the mixed-function oxidation of benzo(a)pyrene in several tissues of untreated and 3-methylcholanthrene-pretreated rats. The enzyme systems in the liver, kidney and stomach were much more susceptible to inhibition than those in the lung, adrenal, colon and small intestine. In all tiss... | 454,558 | [
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0.3747517,
0.2152801,
0.1420116,
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0... |
Cutaneous arteritis with superior vena cava obstruction. | Superior vena cava (SVC) obstruction may occur in several disorders (Urschel & Paulson, 1966) and may be associated with arteritis in Behçet's disease (Chajek & Farinaru, 1975). We report a man who had arteritis and SVC obstruction without any of the known causes. | 454,570 | [
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Lichenoid tattoo reactions. | Two young men, tattooed early in 1977 by the same London tattooist, both rapidly developed lichenoid lesions confined entirely to the red dyed areas. | 454,571 | [
0.1397955,
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0.295246... |
Nanosecond fluorescence anisotropy decays of 1,6-diphenyl-1,3,5-hexatriene in membranes. | Nanosecond decays of the fluorescence anisotropy, r, were studied for the emission of 1,6-diphenyl-1,3,5-hexatriene (DPH) embedded in a series of mixed multilamellar liposomes containing egg yolk phosphatidylcholine, phosphatidylethanolamine and cholesterol in varying molar ratios, as well as in membranes of intact cel... | 454,589 | [
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Translocation and turnover of phospholipid analogs in plasma membrane-derived vesicles from cell cultures. | The time-dependent accumulation of phosphatidyldimethylethanolamine in formaldehyde-induced vesicles obtained from a somatic cell hybrid line was investigated. From a number of considerations including a two-fold enrichment of cholesterol and sphingomyelin it was concluded that these vesicles were derived from the cell... | 454,594 | [
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0.1... |
Mechanism of blockage of amphotericin B channels in a lipid bilayer. | A number of organic compounds (non-electrolytes, tetraalkylammonia, etc.) with a molecular size of 6--8 angstrom decrease the conductance of ionic channels formed in the lipid bilayer by a polyene antibiotic amphotericin B. It is suggested that these compounds, upon entering the channel, block the passage of inorganic ... | 454,595 | [
-0.07440537,
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... |
The evolution of the long and short repetitive DNA sequences in sea urchins. | The rates of evolution of purified long and short repetitive DNA sequences were examined by hybridisation analysis between the DNAs from several species of sea urchins. We find that the rates of nucleotide substitution are very comparable within mutually retained sequences for the two classes of repetitive DNA. The los... | 454,609 | [
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0.03575562,
-0.1818253... |
Isolation and characterization of mitochondrial alanine aminotransferase from porcine tissue. | Mitochondrial alanine aminotransferase L-alanine:2-oxoglutarate aminotransferase, EC 2.6.1.2) has been isolated in homogeneous form from both porcine liver and kidney cortex, but in low yield. Polyacrylamide gel electrophoresis of the purified enzyme in the presence of sodium dodecyl sulfate or 8 M urea gave a single b... | 454,616 | [
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0.... |
Studies on the covalent binding of an intermediate(s) in prostaglandin biosynthesis to tissue macromolecules. | We investigated the covalent binding of intermediates in prostaglandin biosynthesis to tissue macromolecules. Following incubation of [1-14C]arachidonic acid with the microsomal fraction from guinea pig lung, ram or bovine seminal vesicle, human platelets, rabbit kidney, or rat stomach fundus, the amount of covalent bi... | 454,638 | [
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0.6286088,
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Isolation and characterization of the trypsin inhibitors from winged bean seed (Psophocarpus tetragonolobus (L) Dc.). | The trypsin inhibitors from winged bean seed were isolated by affinity chromatography on trypsin-Sepharose 4B and the components fractionated by chromatography on SP-Sephadex C-25 and Sephadex G-100. The major components, inhibitors 2 and 3 were found to be homogeneous proteins with molecular weights of about 20,000. T... | 454,647 | [
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... |
Specific fragmentation of human erythrocyte spectrin by chemical cleavage at cysteine residues. | Spectrin, isolated from human erythrocyte membrane, was specifically cleaved at the amino side of its cysteine residues by reacting it with 2-nitro-5-thiocyanobenzoic acid at pH 8.0 and incubating the product at pH 9.0. Conditions were developed to obtain quantitative cleavage, with virtually no side reactions due to e... | 454,652 | [
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... |
Lanthanide ion probes of structure in biology. Environmentally sensitive fine structure in laser-induced terbium(III) luminescence. | The 488 nm line of the CW argon ion laser provides a convenient visible source for the direct excitation of the emissive 5D4 state of the Tb(III) ion. Room temperature emission spectra of Tb(III) in a variety of environments have been examined under relatively high resolution. The samples studied include structurally w... | 454,662 | [
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0.3271... |
The N-terminal sequence of the ribosomal 'A' protein from two moderate halophiles, Vibrio costicola and an unidentified moderate (NRCC 11227). | The 'A' protein, equivalent to ribosomal protein EL7/L12 from Escherichia coli, has been isolated and purified from two moderate halophiles Vibrio costicola and NRCC 11227. The 'A' protein from V. costicola contained an N-terminal serine and separated into two forms on DEAE-cellulose and two-dimensional electrophoresis... | 454,666 | [
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0.1660141,
0.2437982,
-0.1042334,
0.2230258,
0.07905984,
0.1342913,
... |
Subunits of the extracellular hemoglobin of Tubifex tubifex. | The molecular weight of the extracellular hemoglobin of Tubifex tubifex determined by equilibrium sedimentation is 3.0 +/- 0.2 . 10(6). Polyacrylamide gel electrophoresis in sodium dodecyl sulfate showed that the hemoglobin dissociated into four subunits: 13 000 (subunit 1), 21 000 (subunit 2), 23 000 (subunit 3) and 4... | 454,667 | [
-0.1125211,
0.3459224,
-0.4414635,
0.03484118,
-0.1356664,
-0.1276693,
-0.06506136,
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0.08827205,
-0.1591944,
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0.3459849,
0.1401623,
0.1978385,
0.1085683,
0.0791593,
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-0.06966019,
0.08098076,
0.0334198,
0.1336327,
0.2067568,
0.01453768,
0... |
Proton N.M.R. study of the conformational dynamics of porcine pancreatic colipase. Titration of aromatic residues. | The low-field portion of the 360 MHz proton N.M.R. spectrum of native porcine pancreatic colipase has been studied as a function of pH over the pH range 2-12. Resonances associated with the 26 protons of the aromatic rings of the two histidines, two phenylalanines and three tyrosines have been identified and tentativel... | 454,687 | [
-0.09994955,
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0.03139573,
0.2497542,
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0.01042158,
0.1121299,
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0.2422639,
0.1811751,
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0.09296086,
0.169837,
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0.1749233,
-0.1557138,
-0.03337792,
0.3738888,
-0.08684058,
0.1878056,
... |
[Bacterial membrane proteins. Properties of Micrococcus lysodeikticus NADH dehydrogenase]. | NADH dehydrogenase was isolated from M. lysodeikticus membranes with FAD as a prosthetic group. It was found the enzyme molecular weight is about 140000 in 0,01 M phosphate buffer, pH 7,4 in 1% Triton X-100. The enzyme molecules are dimers consisting of two subunits with molecular weight of 70000. The content of alpha-... | 454,711 | [
-0.1868706,
-0.07289384,
0.15308,
0.315391,
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0.04124365,
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0.09416135,
0.2460194,
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0.264937,
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-0.2480711,
0.02469802,
0.0283136,
0.09933204,
0.5276448,
0.08783804,
-0.0601625... |
[Effects of organic solvent vapors on the protochlorophyllic complex from etiolated leaves. Conditions for reversible and irreversible destruction]. | The spectral properties and the ability of etyolated leaves pigments treated with organic solvent vapours (OS) for phototransformations were studied by measuring low temperature fluorescence spectra (-196 degrees C). Under the effects of OS the fluorescence at 655 nm was gradually decreased and that at 630--640 nm was ... | 454,717 | [
0.08543868,
0.06624039,
0.02536033,
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0.06414235,
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0.1580212,
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0.3415453,
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0.245616,
0.2381499,
0.2640238,
0.2230092,
0.4279721,
-0.3397605,
... |
[Lateral heterogeneity of bacterial membranes]. | Isolated membranes of M. lysodeikticus were rapidly frozen and disrupted in a Hughes press. After disruption the fragments were centrifuged at 144000 g for 1 hour and part of the supernatant just above the pellet was subjected to isopycnic centrifugation in a continuous sucrose density gradient. It was found that the m... | 454,721 | [
0.06289338,
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0.02748792,
0.07271986,
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0.1321059,
0.1370213,
-0.05633549,
0.06692389,
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0.1643046,
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-0.4729027,
-0.1900251,
0.1860513,
0.07305349,
0.359441,
-0.0688741,
0.00822356... |
Tensile strength of bone (bone/porous polyethylene) interface. | An average tensile strength of 1.35 kgf/mm2 (1920 psi) was obtained. Comparison of all results with related studies on metallic and ceramic implants indicates the overall superiority of plastics as porous implants for many applications. | 454,776 | [
-0.05289514,
0.1874847,
0.1474398,
0.0744858,
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0.08667124,
0.08590344,
0.01473771,
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0.365416,
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0.004026402,
0.2344424,
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0.3363525,
0.3091978,
-0.1620251,
0.1187105,
... |
[Study of bromthymol blue-prealbumin in the blood serum of rats under hyperbaric oxygenation]. | Three-fold increase of BTB-prealbumin (Rm 1.0) in rat serum following fierse convulsions under hyperbaric oxygenation (6 ati, 30-35 min) has been proved by disc electrophoresis. Glial S100-protein and 7-fold increase in the all-organ component of brain BTB-prealbumin were found by immunochemistry to appear in the serum... | 454,817 | [
-0.3194008,
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0.2053848,
-0.3110103,
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0.0582976,
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0.4143706,
0.2069459,
0.1324439,
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0.1256322,
-0.0569317,
-0.0590032,
-0.2041135,
0.1864254,
-0.1267793,
... |
[Effect of maternal hypoxia on the neurogenesis of the cerebral cortex of rat progeny (autoradiographic study)]. | Rats with 15-day pregnancy were exposed to two-hour hypoxia corresponding to 8,000 m altitude. On the 18th day of pregnancy they were administered thymidine-3H three times. Quantitative autoradiographic studies were performed on brain cortex neurons of 30-day rat progeny. The animals who had sustained intrauterine hypo... | 454,832 | [
-0.09106372,
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0.006756411,
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0.00233781,
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0.3986115,
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-0.3668864,
0.2616829,
-0.3526847,
0.3517213,
0.2706286,
0.442223,
0.2349874,
... |
The effectiveness of rubidazone in hairy cell leukemia (leukemic reticuloendotheliosis). | Two patients with hairy cell leukemia treated with the anthracycline antibiotic rubidazone are presented. One achieved a complete remission and the other a good partial hematologic and bone marrow remission. Neither has relapsed (at 20 and 13 mo, respectively), and neither has been retreated. Intensive supportive measu... | 454,838 | [
0.04289515,
-0.3860911,
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0.05749468,
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0.008556112,
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0.1884836,
0.1819227,
0.2257082,
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0.3842103,
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-0.1078027,
-0.113019,
0.1707065,
0.3136919,
0.1551865,
0.02900769,
... |
Treatment of chronic oesophageal perforations with special reference to an endoscopic method. | The endoscopic treatment of chronic oesophageal perforations (more than 18--24 h old) by the application of sodium hydroxide 20 per cent to the edges of the perforation is described. The importance of pleural and mediastinal toilet and the accurate siting of drainage tubes and full expansion of the lung, together with ... | 454,987 | [
-0.3031773,
0.1429963,
-0.2294499,
-0.3431097,
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-0.2679614,
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0.08226883,
-0.2436678,
0.1622264,
-0.3964782,
0.03787548,
-0.02427241,
-0.2725165,
-0.1093855,
-0.05082067,
-0.03274063,
-0.1742066,
0.2884746,
0.1403868,
0.1672602,
0.1242144... |
Assessment of carotid artery stenosis using pulse wave transit time. | A prospective study has been undertaken on 24 patients to establish the relationship between the degree of internal carotid artery stenosis, as estimated by arteriography, and the pulse wave transit time in the carotid artery. The technique involves the simultaneous use of two continuous wave Doppler velocimeters, one ... | 454,995 | [
-0.2712157,
-0.1485192,
-0.4730314,
-0.08128623,
-0.03234762,
-0.4006353,
0.04830491,
-0.09594913,
0.05147771,
0.02368795,
-0.06706791,
-0.209097,
-0.367779,
-0.3590514,
-0.2369834,
-0.1520312,
-0.4309036,
0.1897386,
-0.4311613,
0.142408,
0.2039315,
-0.1212165,
0.1643913,... |
Melanoma of the nipple and areola. | Fourteen primary melanomas arising in the nipple and areola of the breast were treated by mastectomy and axillary dissection. Four patients had axillary lymph node metastases and all were dead within 3 years of their operation, while the 10 patients with no axillary node involvement were free from recurrent disease 5 y... | 455,001 | [
-0.06131836,
-0.1521605,
-0.2591994,
-0.4576922,
-0.07721643,
-0.3090542,
-0.06878871,
-0.07468652,
-0.1845074,
0.03961121,
0.32165,
0.02445124,
0.04520807,
-0.2598319,
-0.04275029,
-0.1667421,
0.08492047,
0.03176982,
0.0140758,
0.07091803,
0.6548463,
0.2367035,
0.0610757... |
Increased dopamine concentration in limbic areas of brain from patients dying with schizophrenia. | Dopamine, noradrenaline, glutamate decarboxylase (GAD) and choline acetyl-transferase (CAT) were measured in post-mortem brain samples from more than 50 patients dying with a hospital diagnosis of schizophrenia and an equal number of controls. GAD was measured in 14 different brain regions, and was significantly lower ... | 455,044 | [
-0.1132244,
0.01869461,
-0.07669814,
0.04117403,
-0.06726398,
-0.2866741,
-0.1682495,
-0.3449761,
-0.07816362,
-0.0201844,
0.1619325,
0.3786672,
0.1336608,
0.4542045,
-0.1338248,
0.2997395,
-0.5596188,
0.2626213,
0.06232266,
0.4359844,
-0.008769507,
0.2533776,
-0.2148964,... |
Pontine and extrapontine myelinolysis. | No coherent theory has been advanced to explain either the particular localization of the myelinolytic lesions of central pontine myelinolysis or their pathogenesis. However, several lines of evidence support the generalization that the centre of the basis pontis has a special susceptibility to a metabolic fault. The c... | 455,045 | [
-0.260057,
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0.0262433,
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0.1518754,
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0.09162533,
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0.3946711,
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-0.6804362,
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-0.3907131,
-0.3366021,
0.1290059,
0.1558495,
-0.03895621,
... |
Protein and glycoprotein composition of synaptic junctions prepared from discrete synaptic regions and different species. | Synaptic junction (SJ) were isolated by subcellular fractionation from different areas of the steer brain and from the brains of different species (steer, rat, chicken and human) for the purpose of comparing their protein and glycoprotein composition. The synaptic junction fractions from different brain regions and spe... | 455,075 | [
0.1839945,
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0.199658,
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0.1215692,
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0.2135364,
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0.1672051,
0.1422302,... |
Growth hormone and prolactin secretion in growing domestic fowl: influence of sex and breed. | Plasma growth hormone (GH) and prolactin concentrations were measured between 1 and 24 weeks of age in both sexes of a laying strain of chickens and from 1 to 9 weeks of age in broiler cockerels. 2. GH and prolactin concentrations were highest in young birds and higher in males than in females. 3. In both sexes GH and ... | 455,111 | [
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0.3545045,
-0.03285882,
0.1831221,
0.1951383,
0.1469988,
-0.3122482,
... |
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