title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Improved exposure for excision of rectal carcinomas: initial experiences with a pubic resection technique. | Preliminary experiences with a transpubic approach for carcinoma of the rectum are described. By excising a wedge of pubic bone and freeing the left lateral attachments of the bladder, the entire length of rectum can be exposed, down to the level of the levator muscles. Dissection of the tumor can be performed under di... | 485,621 | [
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Sperm-agglutinating antibodies in infertile couples. | In a selected group of 150 infertile couples, sperm-agglutinating antibodies were examined by a microagglutination technique. Sperm-agglutinating activity was observed in sera from 12 men (8%) and 16 women (11%). Antibodies in seminal plasma were demonstrated in 8 men with correspondingly high serum titers. The type of... | 485,646 | [
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Impaired spermiogenesis as a common finding among professional drivers. | The effect of long-term driving upon spermiogenesis was investigated in 2984 patients, including 281 professional drivers. The incidence of pathospermia was significantly increased among the 281 occupational drivers as compared to other professionals. The ratio of severe pathospermia was increased in proportion to the ... | 485,661 | [
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[Phonomechanocardiographic study of congestive myocardiopathy]. | There were studied 14 patients with congestive myocardiopathy demonstrated by cardiac catheterism at nine, echocardiogramme at five and/or necropsy at four. There were registered mytral insufficiency blowings at thirteen and tricusp insufficiency blowings at five. Of them, there were 11 that presented pathologic noises... | 485,668 | [
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The influence of 2,2-dimethyl-1-(4-methylphenyl)-1-propanone (SaH 50-283) on food efficiency in rats. | The present studies were undertaken to investigate the possible mechanism(s) of action of 2,2-dimethyl-1-(4-methylphenyl)-1-propanone (SaH 50-283) on food efficiency in rats. SaH 50-283, unlike phenformin (DBI), did not inhibit glucose absorption. However, hyperglycemia induced by oral maltose, lactose or starch load w... | 485,687 | [
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The effect of local anaesthetic agents on afferent and motor nerve impulses in the frog. | In the frog nerve-muscle preparation an attempt was made to determine the sites of local anaesthetic activity. The drugs were applied not only to the nerve fiber, but also to other structures of the nerve. Different blocking concentrations proved that the drugs effected different sites. It was shown that small concentr... | 485,692 | [
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Pharmacological evidence of an interaction between serotonergic and dopaminergic neurons in the control of prolactin secretion in male rats. | The purpose of the present study was to investigate the possible interaction between serotonergic and dopaminergic neurons in regulating prolactin (PRL) secretion. We have examined the effect of quipazine, a drug which has been reported to increase plasma PRL levels by acting through a serotonergic mechanism, on PRL re... | 485,703 | [
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On the cardiac efficacy of helveticosol-3',4'-di-nitrate, a new glycoside. | The cardiac and extracardiac effects of a new glycoside, helveticosol-3',4'-di-nitrate (HdN), were compared with those of helveticosol (H) and helveticosol-3',4'-di-propionate (HdP) in isolated guinea-pig heart preparations, in volunteers and dogs. In the atrium and heart, HdN produces positive inotropic effects at the... | 485,727 | [
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Infected left atrial myxoma with bacteremia simulating infective endocarditis. | A 58-year-old man had intermittent fever of eight months' duration following a dental extraction. There were no abnormal cardiac auscultatory findings. Multiple blood cultures yielded Streptococcus mutans. Treatment for infective endocarditis was initiated; however, an echocardiogram suggested the presence of a left at... | 485,751 | [
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Agranulocytosis associated with aprindine therapy. | Aprindine hydrochloride is an antiarrhythmic drug now under investigation. The drug is most effective in prophylaxis of ventricular dysrhythmias. Previously recognized toxic effects include neurological side effects, nausea, vomiting, as well as a reported association with agranulocytosis. To our knowledge, this is the... | 485,754 | [
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The psychological treatment of depression. Evidence for the efficacy of psychotherapy alone, in comparison with, and in combination with pharmacotherapy. | Seventeen clinical trials are identified that test the efficacy of various psychological treatments (behavioral, cognitive, group, marital, interpersonal) alone, in comparison with, and in combination with pharmacotherapy in homogeneous samples of depressed outpatients. I describe the results of these studies, gaps in ... | 485,783 | [
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Cloward's anterior fusion in the treatment of cervical spinal traumatic injury and degeneration. | The aim of this study was to evaluate the long-term results of Cloward's anterior interbody fusion of the cervical spine and to identify the factors influencing them. The series consisted of 29 patients operated on in 1968--75. The indication for operation was in 12 cases intensive radicular symptoms, not responding to... | 485,786 | [
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Measurements of cefuroxime concentration in bone in dogs and man. | Measurements of Cefuroxime levels performed in dogs show a decrease against time in well perfused tissue similar to that in serum, while in bradytrophic tissue--such as bone and articular capsule--there is a distinct rise of these values in the time scale assessed. In similar investigations in man the higher levels in ... | 485,788 | [
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Unhooking of GSB total knee during dislocation of the patella. | This is a case report of a special and undoubtedly rare complication occurring in a hinge joint with a moving instant center such as the GSB total knee joint. The preoperative situation, the history of the incident and the operative report are being described as well as a radiological follow-up. The mechanism of unhook... | 485,789 | [
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A bacteriological evaluation of a programme for preoperative total body-washing with chlorhexidine gluconate performed by patients undergoing orthopaedic surgery. | Twenty-eight orthopaedic patients were taught to wash their entire bodies with chlorhexidine gluconate on two consecutive days preoperatively, starting in their homes. The operation field was also washed a third time. A bacteriological evaluation was performed using contact plates. A significant reduction of the skin f... | 485,793 | [
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Isokinetic torque levels for high school football players. | One hundred fifteen high school football players were screened isokinetically for the knee extensor and flexor torque generating capabilities and muscle imbalances. Each player was tested on a Cybex II at speeds of 30 degrees/sec and 180 degrees/sec. The subjects were stratified by age (15, 16, 17) and by position (lin... | 485,799 | [
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Osteolysis of the ribs in progressive systemic sclerosis. | In a patient with progressive systemic sclerosis (PSS), osteolysis of the posterior portion of the rib cage developed in an insidious fashion, without symptoms or preceding trauma. Six previous examples of rib resorption in PSS are reviewed. The destructive mechanism is unknown but may be related to endarteritis and is... | 485,804 | [
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Investigation of cardiac glycoside levels in human post mortem blood and tissues determined by a special radioimmunoassay procedure. | Even after the introduction of radioimmunological methods the question of a cardiac glycoside causing or contributing to the death of a patient can not be answered satisfactorily. By means of a special radioimmunoassay procedure for digoxin as well as for the structurally related methyl- and acetylderivatives we measur... | 485,851 | [
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[Histochemical study of fat in erythema nodosum]. | Histochemical study of fat in the adipocytes of the subcutaneous adipose tissue in 12 patients with erythema nodosum revealed an upset balance of the oxidation process in fat and accumulation of free peroxide and aldehyde groups. The imbalance in the oxidation processes in the adipocytes in the areas of hemorrhages is ... | 485,885 | [
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Administration of human somatotropin in levodopa-treated patients with Parkinsonism. | To investigate further the role of growth hormone (GH) on the cerebral effects of levodopa, human somatotropin (human growth hormone) was administered to four patients with parkinsonism with varying response to chronic levodopa therapy. The doses of somatotropin (5 IU) were administered on alternate days for four days,... | 485,891 | [
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Hypercapnic alteration of visual evoked responses in acute cerebral infarction. | To determine the effect of inhaled carbon dioxide on acute ischemic cerebral injury, we have compared occipital visual evoked responses (VER) at baseline and during hypercapnia in 20 patients with acute unilateral cerebral infarction (ten with and ten without homonymous hemianopsia) and in ten normal controls. Visual e... | 485,892 | [
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Subacute necrotizing polioencephalopathy. | A previously healthy 20-year-old woman died of a progressive cerebral disease that involved the brain stem and the cerebral hemispheres successively. The illness ran its course in 80 days. Postmortem examination showed a multifocal necrotizing encephalopathy that chiefly affected gray matter structures and that was mai... | 485,894 | [
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Neuropathy with susceptibility to compression aggravated by herniated disk. Early pathological and electrodiagnostic studies. | We describe a patient with a foot drop attributable to both herniated disk and peripheral neuropathy susceptible to external compression. Early electrodiagnostic studies and sural nerve biopsy indicated a role for myelin dysfunction in this disorder. | 485,896 | [
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An atypical case of delayed radiation necrosis of the brain. | A patient had radiation necrosis of the brain after treatment for a chromophobe adenoma of the pituitary. Atypically, and in contrast to most previously reported cases, clinical symptoms and signs were few. The computerized tomographic findings are discussed with a review of the relevant literature. | 485,899 | [
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Epithelialization of the anterior chamber: clinical investigation with the specular microscope. | Four patients, each of whom had had an uncomplicated cataract extraction, were examined because of an apparent epithelialization of the anterior chamber. In each instance, the diagnosis was later verified histopathologically. The involved eye was photographed with the clinical specular microscope and the endothelial ph... | 485,908 | [
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The value of liver scintigraphy in choroidal melanoma. | Radionuclide liver scintigraphy was performed as part of the initial diagnostic evaluation in 35 patients with choroidal melanoma and no overt evidence of extraocular metastic diseases. The scans were normal in all but one patient in whom a solitary hepatic defect (due to an hemangioma) was found. The results of this s... | 485,909 | [
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Aspiration cytodiagnosis of lid tumors. | In five patients, specimens of discrete, subepidermal lid tumors were successfully aspirated with 22- to 24-gauge spinal needles and dianosed cytologically. The simplicity, rapidity of diagnosis, and high accuracy of cytodiagnosis should make it a popular method for the evaluation of clinically puzzling subepidermal li... | 485,915 | [
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Laser iridotomy in closed-angle glaucoma. | An argon laser iridotomy was performed on 53 eyes of 34 patients with closed-angle glaucoma. Technically, all of the iridotomies were successful. Blue irides were more resistant to treatment than brown irides. The iridotomies were performed with high energy of 2 W and a very short exposure time of 0.01 to 0.04 s, thus ... | 485,917 | [
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0.1908909,
0.08615168,
-0.2831586,
0.1636702,
0.1309115,
0.04786156,
... |
"Neural" responses to acoustic stimulation after destruction of cochlear hair cells. | Electrophysiological and histological observations in guinea pig's cochleas after amikacin treatment (14 X 450 mg/kg) confirm the results obtained in a former experiment: clear, short-latency, click-evoked responses were recorded in cochleas with only very few hair cells remaining at the extreme apex. Detailed analysis... | 485,950 | [
0.161108,
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0.003945131,
0.4649768,
0.1408664,
0.0709673... |
Effect of treatment with azathioprine on the responses of rat lymphocytes to phytohaemagglutinin. | The proliferative responses of rat peripheral blood lymphocytes (PBL) and spleen cells to phytohaemagglutinin (PHA) were studied after single or multiple (daily for 4 days) injections of azathioprine (AZ). Lymphopenia developed within 4 h of a single dose (78 mg/kg) of AZ and persisted for at least 72 h. There was no l... | 485,979 | [
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0.326807,
0.07679779,
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0.2178486,
-0.21... |
Alteration in cell division, morphology and motility induced by the toxic principle of lupinosis. | A number of experiments are described in which the effect of the toxins causing lupinosis on cell morphology and motility is examined. The toxins arrested cells in metaphase leading to abnormal profiles, and inhibited leucocyte migration. Similar results were obtained with colchicine on cell division and, from the evid... | 485,986 | [
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0.2452496,
0.4236333,
0.2763657,
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Influence of body temperature on nitrogen transport and decompression sickness in fish. | Incidence of lethal bends and intravascular bubbles has been studied in the eel (Anguilla anguila L.) submitted to hyperbaric air decompressions at temperatures of 17 and 27 degrees C. The fish was an accurate model to seek the nature of the inert gas transport limiting process (diffusion or perfusion) because an incre... | 486,014 | [
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0.3535033,
0.1940099,
0.3216307,
-0.14791... |
Separation of the effects of raised skin and core temperature on performance of a pursuit rotor task. | Performance of a pursuit rotor task was studied during induced cycles of core temperature between limits of 37.9 degrees C and 38.5 degrees C. At each level of core temperature tested (37.9 degrees C, 38.5 degrees C, and 38.5 degrees C) performance was significantly worse during heating, when skin temperatures were hig... | 486,015 | [
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0.1618483,
0.4290273,
0.3436435,
-0.0756570... |
The amino acid sequence of ferredoxin from Triticum aestivum (wheat). | The amino acid sequence of the ferredoxin of Triticum aestivum (wheat) was determined by using a Beckman 890C sequencer in combination with the dansyl--phenylisothiocyanate method to characterize peptides obtained by tryptic, chymotryptic and thermolytic digestion of CNBr-cleavage fragments. The molecule consists of a ... | 486,088 | [
-0.2863773,
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0.00984267,
0.5368795,
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-0... |
Heterogeneity and properties of hepatic dexamethasone-binding proteins. | Evidence from experiments in vivo and in vitro is presented for the presence of three species of dexamethasone-binding proteins in rat liver, which are identified by chromatography on Sepharose 6B or by isoelectric focusing. Although two of these species (DI and DII) possess properties characteristic of a true receptor... | 486,098 | [
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0.09190059,
0.1938113,
0.1293461,
0.05985482,
0.1045979,
0.1553... |
Sensitivity of glucose uptake and lipolysis of white adipocytes of the rat to insulin and effects of some metabolites. | 1. Insulin increased glucose uptake and inhibited lipolysis in white adipocytes of the rat over the same concentration range of the hormone: the half-maximal effects were observed at approx. 10 microunits of insulin/ml. Thus, contrary to previous reports, no difference in sensitivity of the two processes to insulin cou... | 486,114 | [
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0.2058929,
0.016929... |
Subcellular localization of the enzyme that forms mannosyl retinyl phosphate from guanosine diphosphate [14C]mannose and retinyl phosphate. | The subcellular distribution of the enzyme catalysing the conversion of retinyl phosphate and GDP-[14C]mannose into [14C]mannosyl retinyl phosphate was determined by using subcellular fractions of rat liver. Purity of fractions, as determined by marker enzymes, was 80% or better. The amount of mannosyl retinyl phosphat... | 486,123 | [
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... |
Effect of dietary phosphate intake on phosphate transport by isolated rat renal brush-border vesicles. | Renal brush-border membrane vesicles isolated from rats kept for 6-8 weeks on a low-phosphate diet (0.15% of dry matter) showed a markedly faster Na(+)-dependent phosphate uptake than did membrane vesicles isolated from animals kept on a high-phosphate diet (2% of dry matter). Phosphate-uptake rate by brush-border memb... | 486,124 | [
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0.3981681,
-0.0554277... |
The decarboxylation of S-adenosylmethionine by detergent-treated extracts of rat liver. | 1. The production of (14)CO(2) from S-adenosyl[carboxyl-(14)C]methionine by rat liver extracts was investigated. It was found that, in addition to the well-known cytosolic putrescine-activated S-adenosylmethionine decarboxylase, an activity carrying out the production of (14)CO(2) could be extracted from a latent, part... | 486,130 | [
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0.2656797,
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Effects of temperature, metabolic inhibitors and some other factors on fluid-phase and adsorptive pinocytosis by rat peritoneal macrophages. | Low temperature, NaF and 2,4-dinitrophenol could each abolish the pinocytic uptake of 125I-labelled poly(vinylpyrrolidone) or colloidal [198Au]gold by rat peritoneal macrophages cultured in vitro. Cytochalasin B caused only partial inhibition, even at 10 microgram/ml, and colchicine (10 or 25 microgram/ml) inhibited up... | 486,133 | [
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0.... |
Effects of some chlorinated sugar derivatives on the hexose transport system of the blood/brain barrier. | The inhibition of D-glucose transport into brain by several hexose analogues has been investigated in adult anaesthetized rats. D-Glucose was transported with apparent Vmax. = 1.22 mumol/g per min, Km = 11.12 mM and Kd = 0.008 ml/g per min. 6-Chloro-6-deoxyglucose was transported with corresponding values of Vmax. = 1.... | 486,142 | [
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0.005791602,
0.02100522,
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0.1810709,
0.003413... |
Preparation and properties of amphipathic enzyme-polymer conjugates. | Amphipathic enzyme-polymer conjugates were prepared by reaction of hydrophilic enzymes with an anhydride polymer partially substituted with pendant hydrophobic groups. The products formed non-covalent aggregates of high molecular weight, dissociable by non-ionic detergents and urea and subject to additional aggregation... | 486,147 | [
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0.1168237,
0.1777442,
0.02077508,
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0.... |
Dependency upon salbutamol inhalers. | A case of dependency on salbutamol inhalers has been described. This has been discussed in relation to abuse of other drugs by alveolar absorption and other effects of salbutamol. It is not known whether the dependency is due to the salbutamol itself or to the fluorinated hydrocarbons used as propellants. | 486,238 | [
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0.2483598,
0.08612165,
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... |
Gonorrhoea in women in Scotland. Evidence of cohorts having a higher or lower incidence than expected. | Incidences of genital gonorrhoea in women higher or lower than expected occurred in patients aged 15--19 years four years after similar findings in those aged 10--14 years. This pattern was followed five years later in those aged 20--24, 11 years later in those aged 25--34, and 20 years later in those aged 35--44 years... | 486,246 | [
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0.08754574,
0.4287841,
0.6462525,
-0.1878... |
Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study. | Intravenous nifedipine, a powerful calcium antagonist, had no obvious effect on atrioventricular conduction when administered to 11 patients during routine intracardiac electrophysiological studies. Verapamil on the other hand showed potent antiarrhythmic properties, depressing atrioventricular nodal conduction. Nifedi... | 486,272 | [
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0.05523084,
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0.1317951,
0.3656858,
0.08792... |
The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy. | 1 The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes are described. 2 Only one class of binding site can be demonstrated. Binding is time- and temperature-dependent, saturable and slowly reversible; it is inhibited by other cardiac glycosides and by potassium. 3 Pr... | 486,288 | [
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0.1351279,
0.6744332,
0.3479052,
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-0.... |
ICRF-159 enhancement of radiation response in combined modality therapies. I. Time/dose relationships for tumour response. | The combined effect of the chemotherapeutic agent ICRF-159 and irradiation were evaluated using the Lewis lung tumour (LL). At a daily dose of 25 mg/kg, ICOF given alone prevented the progressive growth of LL. Daily pretreatment also potentiated the effects of radiation (600 rad) on tumour growth, provided the pretreat... | 486,307 | [
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0.0001679935,
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0.4525547,
0.3747481,
0.1563739,
-0.0298657... |
Pernicious anaemia and granulomatous skin lesions in a case of common variable hypogammaglobulinaemia. | A 45-year-old woman is reported with a history of recurrent bacterial infections since childhood; at the age of 37 years she developed recurrent ulcerated lesions around her mouth, in the groins and buttocks, which histologically contained small, non-caseating granulomas. A year latter when being treated for empyema, s... | 486,328 | [
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0.06113725,
0.01225881,
0.075531,
0.1624478,
0.1090516,
... |
The specificity of schizophrenic thought disorder. | Bannister and Salmon (1966), in a repertory grid study, reported that 'thought-disordered schizophrenics lost significantly more reliability and social agreement when shifted from object to people construing than normal'. This conclusion is of doubtful validity, since the between-grids variable, people vs. objects, was... | 486,350 | [
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0.04562844,
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0.1277715,
... |
Effects of anxiety on attitudes--a semantic differential study. | Eighteen female out-patients suffering from chronic anxiety states and 25 normal women matched for age filled in an anxiety inventory and completed semantic differential forms on 21 concepts grouped into four areas: characters, locations, human interactions and abstractions. Each concept was rated on 15 scales grouped ... | 486,353 | [
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0.09827064,
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0.3070897,
0.3142072,
-0.18496... |
Agoraphobic women married to abnormally jealous men. | Of 36 married female agoraphobics treated by the author over a period of 3 years, seven were married to men who displayed abnormal jealousy. In all these cases the husbands' jealousy adversely influenced their wives' response to treatment, and improvement in wives was associated with increased morbidity in their husban... | 486,363 | [
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0.3060886,
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0.1190681,
0.1373139,
-0.06931739,
-... |
Capgras: case study and reappraisal of psychopathology. | A case of the Capras phenomenon in a man of 58, arising during the course of a depressive illness, is described. Physical, electroencephalographic and psychometric investigations gave no sign of organic disease, and recovery was complete. Factors leading to the development of a depressive psychosis and its particular m... | 486,375 | [
-0.0781955,
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0.2996599,
0.006545363,
0.1917206,
0.02054168,
-0.2071207,
... |
Assessment of the heart-rate method for determining energy expenditure in man, using a whole-body calorimeter. | 1. The heart-rate (HR) method for determining the energy expenditure of free-living subjects has been evaluated using a whole-body calorimeter in which individuals lived continuously for 27 h while carrying out normal daily activities. Eight male volunteers each occupied the calorimeter on at least two occasions when H... | 486,384 | [
-0.1855881,
0.1809548,
-0.4046175,
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0.1955662,
0.2942849,
-0.09633621,
... |
Preparation of the bifunctional enzyme ribonuclease-deoxyribonuclease by cross-linkage. | Protease-free bovine pancreatic deoxyribonuclease (DNase) (1.6 X 10(-4) mmol) was thiolated on the NH2 groups with N-acetyl-DL-homocysteine thiolactone (2.4 X 10(-2) mmol) at pH 10.5 with imidazole (2.4 X 10(-2) mmol) as the catalyst in the presence of 4,4'-dithiodipyridine (4.2 X 10(-2) mmol). The product obtained aft... | 486,431 | [
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0.1970272,
0.3381079,
0.1714976,
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0... |
A quantitative study of the slow decline of chlorophyll a fluorescence in isolated chloroplasts. | A detailed study of the photo-induced decline in chlorophyll a fluorescence intensity (Kautsky phenomenon) in coupled isolated chloroplasts from a high level (P) to a low stationary level (S) is presented. 1. A linear relationship between P leads to S quenching and intrathylakoid H+ concentration was found. When the li... | 486,438 | [
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0.08436403,
... |
Photochemical reaction of 9-cis-retro-gamma-rhodopsin at low temperatures. | 9-cis-Retro-gamma-rhodopsin (lambda max = 420 nm) was prepared from 9-cis-retro-gamma-retinal and cattle opsin. After cooling to liquid nitrogen temperature (77 K), the pigment was irradiated with light at 380 nm. The spectrum shifted to the longer wavelengths, owing to formation of a batho product. This fact indicates... | 486,439 | [
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0.3274734,
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Ion transport in the simplest single file pore. | A kinetic scheme is developed to describe single-file transport through pores containing up to two ions which may be of different species. The solution for the fluxes in terms of rate constants for entry, exit, and transfer is derived without specific assumptions about symmetry or the voltage and activity dependence of... | 486,451 | [
-0.2576805,
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0.3056542,
0.1038773,
-0.04176... |
Lectin-mediated agglutination of murine lymphoma cells. Cell surface deformability and reversibility of agglutination by saccharides. | Agglutination of S49 mouse lymphoma cells by Ricinus communis I agglutinin can be reversed by the competing haptenic saccharide, lactose, soon after agglutination, but after further incubation in the absence of lectin the agglutination reaction could not be reversed by lactose and the cells remained as multicell aggreg... | 486,456 | [
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0.06997984,
0.3237095,
0.04337329,
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... |
Cholinergic stimulants and excess potassium ion increase the fluidity of plasma membranes isolated from adrenal chromaffin cells. | Chromaffin cell membranes from the bovine adrenal medulla were labelled with the hydrophobic fluorescent probe 1,6-diphenyl-1,3,5-hexatriene, and the fluorescence polarization (P) of the membrane suspensions was measured as a function of temperature. The P versus t profiles, between 20 and 37 degrees C, showed two line... | 486,462 | [
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0.549861,
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0.11... |
Induction of gel-phase lipid in plasma membrane of chick intestinal cells after coccidial infection. | When chickens are infected with the coccidial parasite Eimeria necatrix, the plasma membrane of intestinal cells harbouring second-generation schizonts becomes refractory to mechanical shearing, hypotonic shock and ultrasonication. Plasma membrane from these infected cells was isolated to high purity as judged by enric... | 486,463 | [
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Asymmetric distribution of arachidonic acid in the plasma membrane of human platelets. A determination using purified phospholipases and a rapid method for membrane isolation. | 1. Non-lytic degradation of human platelet phospholipids have been performed using a combination of bee venom phospholipase A2 (phosphatide 2-acyl-hydrolase, EC 3.1.1.4) and Staphylococcus aureus sphingomyelinase C (sphingomyelin choline phosphohydrolase). Under these conditions, 25.4% of total phospholipds are degrade... | 486,472 | [
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0.7853655,
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... |
Distribution in spleen subcellular organelles of sialidase active towards natural sialogylcolipid and sialoglycoprotein substrates. | A procedure was devised for the preparation of enriched populations of subcellular organelles from homogenized bovine spleen. The fractions obtained were characterized for arylsulfatase, succinate dehydrogenase, UDPgalactosyltransferase and 5'-nucleotidase activities. The distribution of sialidase (acylneuraminyl hydro... | 486,491 | [
-0.06908494,
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Dihydropyrimidine amidohydrolase is a zinc metalloenzyme. | Bovine liver dihydropyrimidine amidohydrolase (EC 3.5.2.2) has been subjected to atomic absorption analysis. Three different preparations of homogeneous enzyme indicated that the enzyme contains 4.3 +/- 0.3 g atoms of Zn2+ per mol of enzyme or 1.1 g atoms of Zn2+ per subunit. No Co2+, Mn2+, Mg2+ or Cd2+ was detected. E... | 486,503 | [
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0.1763598,
0.1834808,
0.1728703,
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0.045... |
Adrenal hydroxylations in genetically obese and hypertensive rats. | The separate steps in the formation of aldosterone from cholesterol were studied in a strain of spontaneously hypertensive rats in which phenotypic obesity is inherited as a recessive trait (Koletsky rats). The obese and hypertensive state had little or no effect on side-chain cleavage of cholesterol, formation of prog... | 486,514 | [
-0.05993509,
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0.09819209,
0.1000519,
0.2611273,
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0.03... |
An unusual lipid in the human pathogenic fungus Epidermophyton floccosum. | The dermatophyte Epidermophyton floccosum contains an unusual lipid characterized as 1(3),2-diacylglyceryl-3(1)-O-4'-(N,N,N-trimethyl)homoserine. Its concentration in E. floccosum is approx. 15% of the polar lipids. The role of this lipid in the biosynthesis of polar lipids and fatty acids is not yet known. However, it... | 486,519 | [
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0.7377351,
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The conformation of histone H5 bound to DNA. Maintenance of the globular structure after binding. | Trypsin digestion is used to investigate the conformation of histone H5 when bound to DNA. A central region of H5 comprising residues (22--100) is found to be resistant to digestion and it is concluded that this region is compacted whilst the remaining N- and C-terminal regions are more extended. Since this is the same... | 486,528 | [
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Combined dynamics of EEG and evoked potentials. II. Studies of simultaneously recorded EEG-EPograms in the auditory pathway, reticular formation, and hippocampus of the cat brain during sleep. | This study is carried out on single (not averaged) recordings combining the spontaneous activity preceding the stimulus onset and the EP recorded upon acoustical stimulation. These recordings, which we call EEG-EPograms, are measured simultaneously from different subdural structures, such as the auditory cortex, medial... | 486,590 | [
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0.09986214,
0.03047924,
0.1479993,... |
Fourier analysis of spike train data. | A formal representation of nerve spike trains in the form of a sum of rectangular functions is proposed. This formal instantaneous frequency function can be Fourier analyzed. The resulting algorithm has the useful properties of spike by spike calculations and an insensitivity to the mean (carrier) spike rate. The techn... | 486,591 | [
0.05442003,
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0.1204008,
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0.09534232,
0.214523,
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0.025046... |
Activity analysis of neural networks. | In a series of articles (Leung et al., 1973, 1974; Ogŭztöreli, 1972, 1975, 1978, 1979; Stein et al., 1974) we have investigated some of the physiologically significant properties of a general neural model. In these papers the nature of the oscillations occuring in the model has been briefly analyzed by omitting the eff... | 486,594 | [
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0.3341068,
0.2206139,
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... |
In vitro estimation of the proliferative state of murine bone marrow "colony forming units in culture" (CFUc) with hydroxyurea (HU). | Exposure of CFUc to 1.0 mM of HU for two hours was at the plateau of both the dose--and time--respose curves, killing 38% of the CFUc. This is compatible with the result of the 3HTdR "suicide" method, a standard procedure for the estimation of the proportion of CFUc being in the S phase. | 486,692 | [
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... |
Statistical-mechanical theory of passive transport through semipermeable membranes. | The first general multicomponent equations for transport through semipermeable membranes are derived from basic statistical-mechanical principles. The procedure follows that used earlier for open membranes, but semipermeability is modelled mathematically by the introduction of external forces on the impermeant species.... | 486,702 | [
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Influence of the 6-trimethylsilyl group on the fragmentation of the trimethylsilyl derivatives of some 6-hydroxy- and 3,6-dihydroxy-steroids and related compounds. | The 25 eV mass spectra of the trimethylsilyl derivatives of a number of 6-hydroxy and 3,6-dihydroxy steroids together with deuterium and 18O-labeled analogs have been examined to determine the influence of the 6-OTMS group on fragmentation patterns. Ions in the cholestane series at m/z 321 and 403 were the most charact... | 486,706 | [
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0.... |
Separation and determination of oleic and cis-vaccenic acids by gas-liquid chromatography mass spectrometry using a polar cyanopropylsiloxane liquid phase. | The separation and quantification of the monoenoic isomeric oleic (cis-9-octadecenoic) and cis-vaccenic (cis-11-octadecenoic) acids as their pyrrolidine derivatives, was studied with a gas chromatograph mass spectrometer system using mass chromatography. By monitoring the characteristic ions of the pyrrolidine derivati... | 486,707 | [
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... |
Mass-transfer effects on the rate of isomerization of D-glucose into D-fructose, catalyzed by whole-cell immobilized glucose isomerase. | The investigated catalyst system consists of immobilized Arthrobacter cells containing the enzyme glucose isomerase, which catalyzes the isomerization of glucose into fructose. The internal structure of the catalyst was determined from electrom microscope photographs of replicas of freeze-etched catalyst. On the basis ... | 486,717 | [
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An electrochemical sensor for continuous intravascular oxygen monitoring. | The intravascular PO2 sensor described in this paper essentialal routine use. The small dimensions of the sensor permit its introduction into the vessel through a conventional guiding catheter size 4 F or larger. With 5 F catheters, simultaneous blood sampling and/or blood pressure measurement is possible. The accuracy... | 486,722 | [
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0.226... |
[Treatment of rhabdomyosarcoma in mice C3H/He by Co 60 and hyperbaric oxygen (author's transl)]. | Experimental study of rhabdomyosarcoma with successive transplantation upon C3H/He mice, treated by irradiation (Co 60) and combined irradiation-hyperbaric oxygen (HBO), dating from 3, 14 and 15 days after transplantation. The data (tumor volume evolution, histological modifications, pulmonary metastases) are compared ... | 486,730 | [
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0.4488907,
0.2356353,
0.1498907,
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Influence of Temik (aldicarb) on herbicide persistence in cultivated cotton field soil under field conditions. | The effect of the insecticide Temik on the persistence of the herbicides Cotoran and Cobex was investigated in cultivated cotton fields. Temik was applied to the soil which had also been treated with Cotoran or Cobex. Residues were determined at 15 day intervals for four months. Temik was found to inhibit the degradati... | 486,774 | [
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... |
The jaundiced patient. | Jaundice is a rewarding condition to investigate because an explanation is usually found. A preliminary diagnosis based on the clinical features and liver function tests is made. Specialized investigations are then undertaken. In cholestasis or if the diagnosis is in doubt an obstructing lesion must be excluded. Ultras... | 486,831 | [
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... |
Differential effects of noise and incentives on learning. | Three experiments are reported. In the first, monetary incentives improved the learning of nonsense words in response to colours only when the test order was the same as presentation order. In the second, incentives increased the recall of spatial location which served as an additional retrieval cue for nonsense words.... | 486,862 | [
0.1507504,
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0.1956988,
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Lingual thyroid: a review of 12 cases. | Twelve patients with lingual thyroid are reviewed. Two of these patients had a follicular carcinoma in the ectopic gland and both are well 5 and 16 years after treatment. The diagnosis is essentially clinical but confirmation may be made with a thyroid scan. Six patients were treated conservatively with thyroxine with ... | 486,909 | [
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... |
Effect of epidural analgesia on metabolic profiles during and after surgery. | Blood concentrations of glucose, lactate, alanine, free fatty acids, glycerol and 3-hydroxybutyrate were measured during 24 h in 12 females undergoing elective hysterectomy under either general anaesthesia or epidural analgesia extending from T4 to S5. The results showed that the peroperative and immediate postoperativ... | 486,911 | [
0.1287058,
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0.4820688,
0.1283345... |
Carcinoma of the thyroid. | Total thyroidectomy with excision of any enlarged cervical lymph nodes was the usual operation practised for carcinoma of the thyroid in this series. Extended thyroidectomy afforded cures in some patients with locally advanced disease. Preoperative drill biopsy of the goitre was a useful procedure. Other noteworthy fea... | 486,916 | [
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0.315913,
0.1968387,
-0.2576937... |
Deficits in luminous flux discimination by cats with lesions of the superior colliculus-pretectum. | (1) Intact cats and cats relearning or initially learning after bilateral ablation of the superior colliculus-pretectum were trained on a simple flux discrimination in a straight maze where the stimuli were either immediately side by side at the end of the runway or were separated by an opaque barrier. (2) After ablati... | 487,088 | [
0.1048658,
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-0.2515196,
-0.3617428,
-0.7255318,
-0.1792338,
-0.6706863,
0.1474727,
0.06854478,
0.2631752,
-0.046268,
0.1473636,
0.1868843,
0.124501,
-0.1047484,
-0.5653071,
0.008679653,
-0.259573,
-0.156556,
0.11854,
0.3489489,
0.1068283,
0.231484... |
Conductance changes during bath application of beta-alanine and taurine in giant interneurons of the isolated lamprey spinal cord. | (1) Input conductances of giant interneurons in the isolated spinal cord of lampreys were measured with two separate intracellular electrodes. Bath applications of 0.4--3 mM beta-alanine and taurine produced large, reversible conductance increases which were Cl-dependent. (2) Strychnine at 1--2.5 microM might be a comp... | 487,090 | [
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0.4844623,
0.298753,
0.1902368,
0.168839,
0... |
L-[3H]Carnosine binding in the olfactory bulb. II. Biochemical and biological studies. | During the first 10 days after peripheral deafferentation of the mouse olfactory bulb stereoselective binding of L-[3H]carnosine declines markedly. The initial phase of this decline is due to a decrease in binding site stereoselectivity, which is then followed by a loss of assayable binding sites. The specificity of in... | 487,125 | [
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0.01832159,
0.2255445,
0.1513921,
0.07124289,
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... |
Morphological evidence that reline SMR and human mu are analogous rhythms. | In cats implanted with epidural screw electrodes over sensorimotor cortex, various recording montages were used to observe the waveform of the sensorimotor rhythm (SMR). It was found that in bipolar recordings spanning the crus, SMR exhibited a wicket-shaped waveform comparable in shape and polarity to the human mu rhy... | 487,196 | [
0.07860689,
0.3821892,
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0.1194882,
0.3264569,
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0.2339774,
0.2303866,
0.07631554,
-0.17... |
Elevation of calcitonin immunoreactivity in the pituitary and thyroid glands of genetically obese rats (fa/fa). | This paper contains the first demonstration of quantitative changes in the levels of calcitonin-like immunoreactivity in the pituitary. The concentration of calcitonin-like material in lean Zucker rats (?/+) was 0.42 +/- 0.09 ng/mg wet weight of pituitary. The pituitaries of obese rats (fa/fa) contained significantly g... | 487,213 | [
0.02728169,
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0.1505137,
0.06317326,
0.3101134,
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0.1808564,
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0... |
A comparison of the effects of continuous ketamine infusion and halothane on oxygenation during one-lung anaesthesia in dogs. | It has been shown that a continuous infusion of ketamine during one-lung anaesthesia combined with a 50 per cent oxygen-curare anaesthetic technique will provide consistently lower shunt fraction and higher Pao2 compared with halothane under the same experimental conditions. Because no additional factor was observed wh... | 487,234 | [
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0.3016846,
0.04825936,
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0.089579,
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0.1566491,
0.1304578,
-0.02395026,
-0.1184222,
-0.1735338,
0.351895... |
The effect of wheat germ agglutinin on sialyl and galactosyltransferases of rat liver Golgi membranes. | The sialyltransferase and galactosyltransferase activities of the Golgi-rich fraction from rat liver were enhanced by the binding of wheat germ agglutinin (WGA). The sialytransferase was more sensitive than the galactosyltransferase to the WGA. Maximal stimulation of the galactosyltransferase activity resulted from the... | 487,241 | [
0.13239,
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0.5717478,
0.06867923,
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0.03020306,
0.02498211,
-0.0962362,
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0.02199201,
0.1960917,
0.08703886,
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0.2142897,
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0.05329549,
-0.06723095,
-0.08202625,
0.1736981,
0.2228428,
-0.1726305,... |
Cell-free synthesis of rat liver zinc-thioneins. | The induction of rat liver zinc-thioneins mRNA was studied in a wheat germ cell-free translation system. Liver poly A rich polysomal RNA was isolated from rats which had been injected with zinc sulfate 5 h previously. These RNA preparations stimulated the incorporation of [35S]cystine into trichloroacetic acid insolubl... | 487,243 | [
-0.149213,
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0.01009853,
0.2384681,
0.1926213,
0.05571788,
0.3001276,
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0.06493834,
0.294185,
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0.04524949,
0.6100085,
0.1101129,
-0.2747426,
0.16... |
Falciform fold of retina. | A boy of 2 had evidence of congenital retinal non-attachment. The mother had a veil like fold in one eye. There was no evidence of any systemic disorder. The inheritance might be X-linked recessive. Mild manifestations of the disease in the carrier mother may be more frequent than has been assumed and should be looked ... | 487,257 | [
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0.06325671,
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0.1085235,
0.1514099,
0.48965,
0.08392147,
-0.06693033,
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0.1204764,
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-0.1293039,
0.0747951,
0.1719759,
0.014722... |
Central antihypertensive properties of muscimol and related gamma-aminobutyric acid agonists and the interaction of muscimol with baroreceptor reflexes. | The central antihypertensive properties of four gamma-aminobutyric acid (GABA) analogs were characterized in anesthetized cats with implanted intracerebroventricular cannulae. An intracerebroventricular infusion (icv) of muscimol, 0.1--0.5 microgram/min (total dose: 1--5 micrograms, icv), substantially reduced mean art... | 487,268 | [
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0.3568354,
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0.1193648,
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0.06010776,
0.06222271,
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-0.7785394,
0.3190562,
-0.004326423,
0.05536356,
0.05228664,
-0.04073857,
0.24205... |
The effect of propranolol and dimethylpropranolol on cardiac conduction. | Isolated dog hearts perfused with blood from a donor dogand driven at two heart rates were used to compare the effects of propranolol with those of its quaternary ammonium derivative on atrial, atrioventricular (AV) nodal, and His-Purkinje conduction. Propranolol slowed only AV-nodal conduction, increasing the minimal ... | 487,271 | [
-0.267709,
0.1838835,
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0.08683432,
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0.02532743,
-0.1497518,
0.5221185,
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0.2407075,
0.06852644,
0.03236588,
-0.1386338,
0.1469444,
-0.1717394,
... |
Acetylcholine does not stimulate the release of growth hormone from perifused rat adenohypophyses. | Acetylcholine (1 micromol/L--1 mmol/L) has been reported to stimulate growth hormone release from perifused bovine pituitary slices. We have carried out studies using the perifused pars distalis of the rat adenohypophysis to see whether a similar response is observed. Neither acetylcholine, acetylcholine with eserine, ... | 487,284 | [
0.01564983,
-0.3037924,
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-0.05664394,
0.1900311,
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0.2638542,
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-0.057859,
0.1286545,
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0.2540784,
0.04589526,
0.117922,
0.40064,
0.133695,
-0.04705979,
-0... |
[Criteria of the diagnosis and treatment of carotid atheromatosis]. | This retrospective study concerning 102 patients was undertaken to study the therapeutic decisions in these patients when they presented with symptoms of cerebral vascular insufficiency, mostly from the territory of the carotid artery, either transient or accompanied by a deficit. The current literature on the subject ... | 487,299 | [
0.07327463,
0.007259743,
0.08899854,
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0.3300337,
-0.1745115,
0.4432709,
0.1604036,
-0.03474646,
0.116680... |
Regulation of respiration in Friedreich's ataxia. | Friedreich's Ataxia (F.A.) is a degenerative disease which commonly leads to premature death of cardiorespiratory origin. To explain the early death of these patients, previous investigations have established the existence of 1) a cardiomyopathy in nearly 100% of cases, 2) a restrictive pulmonary syndrome of scoliotic ... | 487,304 | [
-0.1307821,
-0.3078439,
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0.3394152,
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0.01481183,
-0.1712559,
0.1564155,
-0.09153391,
-0.1534433,
-0.2... |
Cold induced rhabdomyolysis in carnitine palmyityl transferase deficiency. | A case of carnitine palmityl transferase deficiency in skeletal muscle is described. The usual symptoms associated with this disease (recurrent muscle cramps or pain and pigmenturia) were observed but sudden exposure to cold precipitate rhabdomyolysis in this patient. | 487,329 | [
0.01520915,
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-0.1002239,
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0.1102245,
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0.2756906,
0.1451709,
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0.320702,
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0.08003625,
-0.1366591,
0.2203016,
-0.3977761,
... |
The influence of the supervision of psychotherapy upon being therapeutic. II: Modes of influence of the supervisory relationship. | Through supervision, the student develops those innate personal characteristics which are highly important in being therapeutic. In making conscious use of "reality identification" by the student with his teacher, we must take care to avoid certain pitfalls. What is not wanted is transference identification. To help av... | 487,343 | [
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0.2003324,
0.007969501,
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0.2657301,
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0.0159911,
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0.1484563,
0.3762811,
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0.02506011,
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0.1379862,
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0.1835208,
-0.5087451,
-0.1527701,
0.1582001,
0.3350193,
0.02837343,
0... |
Patient management in disulfiram implant therapy. | Data from 100 disulfiram implant, placebo, and no-implant control patients demonstrate the effectiveness of the disulfiram implant in keeping the alcoholic dry. However, the superiority of the disulfiram implant group over the placebo group is interpreted as evidence of a pharmacological component to the procedure oper... | 487,347 | [
-0.3471187,
0.07417826,
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0.03822274,
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0.08043182,
0.144464,
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-0.03327787,
-0.09203011,
0.1056555,
-0.09089142,
0.07959411,
-0.093687... |
Structural studies on the capsular polysaccharide from Klebsiella serotype K64. | Partial hydrolysis with acid, methylation analysis (including uronic acid degradation), Smith degradation, and p.m.r. spectroscopy have been used to determine the primary structure of the capsular polysaccharide of Klebsiella serotype K64. The hexasaccharide repeating-unit, which also contains one O-acetyl substituent,... | 487,363 | [
0.08452456,
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0.06086596,
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0.063077,
0.27562,
0.2213475,
0.2717209,
0.2840926,
-0.0542516,
0.05296016,
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0.2084365,
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0.1845175,
0.3218972,
0.05009808,
0.4145021,
0.02084537,
-0.1718598,
-0.0... |
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