title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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New observations on the innervation of striated ducts in submandibular glands of cats, including possible peptidergic nerves. | The presence of hypolemmal axons between striated duct cells in submandibular glands of cats has been established electron microscopically. Axons were found between "light" cells, between "light" and "dark" cells and between "light" and basal cells. Hypolemmal axons were observed most frequently in the junctional regio... | 487,394 | [
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Autoradiographic localization of 3H-glucocorticoids and 3H-cortexolone in mouse pituitary. | Autoradiograms of mouse pituitaries were prepared 30 min after injection of 3H-dexamethasone (3HDM), 3H-corticosterone (3HB) and 3H-cortexolone (3HS) either alone or in the presence of competing unlabelled steroids. 3H-dexamethasone accumulated in cell nuclei of both the pars distalis and the pars nervosa but not in th... | 487,400 | [
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Intracardiac M-mode echocardiography for continuous left ventricular monitoring: method and potential application. | Because no accurate and readily applied method exists for continuous recording of left ventricular cavity dimensions and wall motion in man, we designed a catheter-mounted echocardiographic probe. The purpose of this report is to describe the instrumentation, technique, limitations, complications and preliminary observ... | 487,417 | [
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Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. | We constructed cloned DNA sequences complementary to unselected mRNAs [poly(A)+ cytoplasmic RNA] from Chinese hamster ovary cells and used them in RNA:DNA hybridization experiments. Each cloned DNA hybridized a single mRNA from 1.3-3.5 kb in length. The relative rates of labeling (transcription rates) of nuclear RNA co... | 487,428 | [
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A three-dimensional study of organelle interrelationships in regenerating rat liver. 4. Multivesicular bodies. | Double-membraned plasma-membrane-loops are formed from the plasma membrane and released into the cytoplasm. The vesiculation of mainly their inner membrane may transform them into MVB. The so-formed internal vesicles contain cytosol. In many MVB the surface of all their internal vesicles to gether corresponds well with... | 487,456 | [
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[Is conservative treatment justified in the case of advanced infantile tuberculosis of the hip? (author's transl)]. | In the case of advanced children tuberculosis of the hip, the authors propose a more active treatment than Wilkinson's, which is less conservative. A local curetting is important, and if the acetabulum reveals a geodic aspect, this surgery may be done by pelvic approach. After an orthopedic traction, the surgical metho... | 487,495 | [
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[The epiphyseal defect in children (author's transl)]. | The authors produced four cases which all show at first almost the same radiographical espect: an epiphysal defect of the knee. The first case developed in an inflammatory context and proved to be an osteomyelitis. The second case showed a begnin tumour on X-Ray examination a chondroblastoma. Then an epiphysal tubercul... | 487,503 | [
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[Incontinence after repair of imperforate anus : treatment by a free muscle transplant (author's transl)]. | A case of severe anal incontinence after multiple surgical repairs for ano-rectal imperforation is presented. A successful formation of a new puborectalis sling by means of free autogenous palmaris longus muscle transplantation according to Hakeliuis is reported. The clinical success is confirmed radiologically and ele... | 487,513 | [
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The electrocardiographic and antiarrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations. | The electrocardiographic effects of imipramine hydrochloride at therapeutic plasma concentrations were determined in 44 depressed patients during a 6-week clinical outcome study of depression. During each week of the protocol, i.e., 2 weeks of control and 4 weeks of drug treatment, a standard 12-lead ECG, high-speed, h... | 487,538 | [
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Short chain fatty acids in plasma and brain: quantitative determination by gas chromatography. | A reliable and practicable method for the determination of short chain fatty acids in plasma and brain tissue is presented. The sample preparation by partition chromatography on silicic acid allows subsequently a quantitation of short chain fatty acids without interference by methylmalonic acid, or other more polar com... | 487,569 | [
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A highly specific 125I-radioimmunoassay for cholic acid conjugates. | Several modifications of the immunization procedure permitted development of a highly specific radioimmunoassay (RIA) for cholic acid conjugates. Antiserum was produced in guinea pigs using cholic acid-thyroglobulin complex as immunogen. 125-I-Cholyglycylhistamine was prepared as radioactive ligand according to a modif... | 487,571 | [
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A rapid ultraviolet spectrophotometric procedure for the microdetermination of theophylline (1,3-dimethylxanthine) in plasma or serum. | An ultraviolet spectrophotometric procedure for the microdetermination of theophylline in plasma is described. Theophylline is extracted at pH 5 with chloroform. An aliquot of the solvent is shaken with molar hydrochloric acid and the absorbance of the acid layer determined at 267 nm. The resulting procedure is rapid, ... | 487,577 | [
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Plasma spermine concentrations of patients with benign and malignant tumours of the breast or prostate. | A radioimmunoassay has been developed for the measurement of plasma spermine concentrations. The sensitivity of the method is 1 pmol spermine/100 microliters plasma and the crossreactivity was 12% with spermidine and 0.18% with putrescine. Plasma spermine levels of patients with benign and malignant tumours of the pros... | 487,578 | [
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Automated radioimmunoassay of nicotine. | We have developed an automated nonequilibrium procedure for the radioimmunoassay of nicotine. The use of a unique iodinated nicotine derivative in this procedure gave a sensitivity of 10 micrograms/l for nicotine with a between-run precision of 7.4% and within-run precision of 6.0%. Nicotine levels of 60 to 67 microgra... | 487,585 | [
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Determination of noradrenaline and adrenaline in plasma by a radioenzymatic assay using high pressure liquid chromatography for the separation of the radiochemical products. | Plasma catecholamines are determined by a radioenzymatic assay using high pressure liquid chromatography for the separation of the labelled radiochemical products. Noradrenaline and adrenaline are converted to their O-methylated analogues, normethanephrine and metanephrine, by the enzyme catechol O-methyltransferase in... | 487,592 | [
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Congenital goitre and hypothyroidism with impaired iodide organification and high thyroid peroxidase concentration. | A sibship of thirteen subjects whose parents were first cousins was studied for a defect in thyroid hormone synthesis. Five sibs were goitrous and had congenital hypothyroidism. All but one showed a positive perchlorate discharge test (PDT). Three other subjects were goitrous and euthyroid (one with a positive PDT), an... | 487,612 | [
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Radiation-induced hyperprolactinaemia in a treated acromegalic. | A 31-year-old acromegalic was normoprolactinaemic after partial removal of her pituitary tumour. The post-operative external pituitary irradiation lowered the mean growth hormone (GH) level from 75 mU/1 to less than 1 mU/1 within 2 years. However, at the same time hyperprolactinaemia developed. These changes in the GH ... | 487,615 | [
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Features of trisomy 18 and 18p- syndromes in an infant with 45,XY,i(18q). | An isochromosome for the long arm of chromosome number 18 - 46,XY,i(18q) - was found in an infant who had features of both trisomy 18 and 18p- syndromes. Findings compatible with trisomy 18 included postmature delivery, prominent occiput, severe congenital heart disease, overlapping fingers, and rocker-bottom feet. Tho... | 487,637 | [
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Immunological investigation in adenine phosphoribosyl transferase (APRT) deficiency. | In a family with partial or total adenine phosphoribosyl transferase (APRT) deficiency, T and B cell function was evaluated by counting rosette-forming cells, by investigating lymphocyte transformation to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), by assaying serum immunoglobulins and... | 487,640 | [
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Circulating immune complexes in various thyroid diseases. | In a study of 171 patients with various thyroid diseases, circulating immune complexes (CIC), measured by a C1q solid phase radioassay, were detected in 26% of the patients as compared to 8% of the control subjects. CIC were found in 33--55% of the patients with a well defined thyroid autoimmune disorder (Hashimoto's g... | 487,642 | [
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A longitudinal study of immunological parameters in multiple sclerosis: cell-mediated immunity and complement profiles. | In a 1 year longitudinal study of twenty-two patients with multiple sclerosis (MS) and twenty-one normal control subjects, peripheral blood leucocytes were stimulated with lipoplysaccharide (LPS), a B cell mitogen, and phytohaemagglutinin (PHA) a T cell mitogen. EA- and EAC-rosette formation was also performed to assay... | 487,645 | [
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The spleen is required for the suppression of experimental allergic encephalomyelitis by prostaglandin precursors. | In this paper we report a study of the effects of splenectomy on the immunosuppressive action of essential fatty acids (EFA) which is thought to be mediated through prostaglandins (PG) produced in the spleen. Experimental allergic encephalomyelitis (EAE) was induced in normal, splenectomized and sham splenectomized Lew... | 487,646 | [
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Corticosteroid enhancement of immunoglobulin synthesis by pokeweed mitogen-stimulated human lymphocytes. | The effects of the addition in vitro of corticosteroid on pokeweed mitogen (PWM) induced Ig synthesis by human peripheral blood lymphocytes were studied. IgG in supernatants produced under standardized culture conditions was measured by double antibody radioimmunoassay. The addition of 10(-6)M prednisolone caused a rem... | 487,651 | [
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Proteolysis of human IgG by human polymorphonuclear leucocyte elastase produces an Fc fragment with in vitro biological activity. | The Fc fragment derived by proteolysis of human IgG by human polymorphonuclear leucocyte (PMN) elastase was tested for in vitro biological activity. This fragment could attach to the specific IgG receptor of Staphylococcus aureus Cowan I cells (protein A) and could be eluted from the cells with dissociating buffer. Tak... | 487,653 | [
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Heterogeneity of anti-mitochondrial antibodies: characterization and separation of the antigen associated with the pseudolupus erythematosus syndrome. | It could be shown that anti-mitochondria antibodies (AMA) found in drug-induced pseudolupus erythematosus syndrome (PLE) had a different specificity from those found previously in primary biliary cirrhosis (PBC). The PLE antigen could be easily separated from the PBC antigen either by isopycnic sucrose density gradient... | 487,658 | [
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Effects in normal subjects of long-term administration of azosemide. | Azosemide is a new loop diuretic which has been shown to affect solute transport proximal to the diluting segment. We assessed the effects of chronic administration of azosemide in normal subjects on low and normal salt diets. In both, there was compensatory renin release and aldosterone secretion, but the subjects on ... | 487,690 | [
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Haloperidol-induced syndrome of inappropriate secretion of antidiuretic hormone. | Several psychotropic drugs have been associated with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). We report here a patient who on two occasions developed clinically significant hyponatremia while receiving the antipsychotic drug, haloperidol. The criteria for the syndrome of inappropriate se... | 487,691 | [
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Resistance to mental health consultation directed at change in public institutions. | Mental health consultants need to be aware that institutions in a community are frequently resistant to change. Official agreement that change is necessary may still evoke resistance by those individuals most threatened in the agency. The consultant's awareness of how such resistance is manifest and used permits some e... | 487,749 | [
-0.4926302,
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0.1114305,
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0.1983566,
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0.1070903,
0.2620071,
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0.01415667,
0.3381231,
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0.05694546,
-0.07186069,
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-0.00846989,
... |
Perceptional differences in the supervision of paraprofessional mental health workers. | Paraprofessional mental health workers and their supervisors completed critical incident questionnaires describing their most and least helpful supervision experiences. A categorical scheme summarizing these critical supervision experiences was developed. A comparative analysis indicated that both the paraprofessionals... | 487,751 | [
-0.1889686,
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0.04210088,
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0.004290881,
0.1290839,
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0.06668621,
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0.04591834,
-0.1204335,
0.3114478,
0.2182694,
... |
A computer program for survival comparisons to a standard population. | PROPHAZ is a computer program created for the analysis of survival data using the general proportional hazards model. It was designed specifically for the situation in which the underlying hazard function may be estimated from the mortality experience of a large reference population, but may be used for other problems ... | 487,785 | [
-0.1178907,
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0.02905492,
0.3235214,
0.07813179,
0.007666181,
0.282836,
0.2222645,
0.2365762,
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0.3681874,
0.4736278,
0.03217245,
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0.1... |
Preliminary report of a new method of whole body CT-scanning. | The authors suggest a new approach to CT-body examination derived from their experience in spinal investigations. They introduce a method of gantry tilt in association with inclination of the patient, and call the new mode "longitudino-axial sectioning". This method makes possible the simultaneous display of several ve... | 487,795 | [
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0.02365532,
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0.1079734,
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0.2535865,
0.1249074,
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0.1044115,
0.1219591,
0.0417772,
... |
Reversion of supraventricular tachyarrhythmias by means of atrial stimulation. | Thirteen patients with different forms of supraventricular tachyarrhythmia were treated by means of right atrial pacing. Reversion of arrhythmia was obtained in nine out of ten patients with atrial tachycardia or flutter. The remaining three patients, with atrial fibrillation, did not respond to the procedure. The effe... | 487,836 | [
-0.4237813,
0.09355242,
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0.1026307,
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0.02887961,
0.09077042,
0.112094,
0.3208298,
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0.1430501,
0.1578894,
-0.2673063,
0... |
A long-term postoperative follow-up in craniopharyngioma. | The long-term postoperative follow-up of children treated for craniopharyngioma is influenced by the patient's age at time of diagnosis, tumor location, texture, interface and adherence to brain, and achievements of the first operation. These factors will be examined as they apply to 51 children treated at the Hospital... | 487,872 | [
0.08053796,
0.04311176,
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0.008857539,
0.3245544,
0.282142,
0.2753122,
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0.2454127,
0.0009629693,
0.06328934,
0.05964325,
0.1860735,
-0.2963... |
Matching behavior in the young infant. | Infants as young as 2--6 weeks have been reported to exhibit matching behavior in response to seeing an adult model tongue protrusion and certain other acts. Matching behavior to the tongue model declines by 12 weeks. The present study was designed to investigate whether (1) this matching behavior represents selective ... | 487,882 | [
-0.1705161,
0.2555816,
-0.437238,
0.07533528,
0.4442569,
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0.1016532,
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-0.2073289,
0.2602041,
0.08626664,
0.04038228,
... |
Matching of auditory-visual and temporal-spatial information by seven- and nine-year-old children. | Techniques of presenting information temporally in the auditory and visual modalities and spatially in the visual modality were used to assess information processing in 7- and 9-year-old children. The results of the study were interpreted as contradictory to the view that modalities are specialized for the processing o... | 487,892 | [
-0.4128009,
0.1106056,
-0.4939801,
0.0123662,
0.1447451,
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0.05113209,
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0.07090079,
-0.1800618,
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0.2068969,
-0.552718,
-0.2538987,
0.2379919,
0.3335494,
-0.08005615,
... |
Visualization of Transcription in early mouse embryos. | Transcriptional activity during early mammalian embryogenesis was examined in 2 cell, 4--8 cell and late morula/early blastocyst mouse embryos. Zona pellucida-free embryos were obtained after pronase digestion followed by a PMSF wash to inhibit proteolytic activity. The embryos were then lysed with NP40 detergent and s... | 487,909 | [
0.2563053,
0.02007826,
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0.06317418,
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0.1576528,
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0.04274003,
0.6278508,
0.130527,
-0.2134734,... |
Prognosis of Crohn's disease with onset in childhood or adolescence. | A long-term follow-up study of 522 patients (1955-1974) with onset of Crohn's disease under age 21 was conducted. Follow-up information was obtained for 513 (98.4%) of the patients. The mean follow-up for the entire series was 7.7 years with a greater than five-year follow-up for 67% of patients. Nearly 60% of the pati... | 487,911 | [
0.05744257,
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0.04745682,
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0.07897944,
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0.291591,
0.1352409,
0.1222557,
0.288449,
0.4505788,
-0.1395792,... |
A chylous mesenteric cyst and a study of its contents. | A case of a patient with a large chylous cyst in the mesentery of the small intestine is presented. After excision of the cyst, the chyle was analyzed with special reference to its protein and lipid content. The composition of the chyle compared with that of intestinal lymph of experimental animals suggests that the fl... | 487,917 | [
-0.07758852,
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-0.132184,
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0.07081294,
0.06765299,
0.2077148,
0.2371849,
0.1112821,
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-0.02478775,
0.1588379,
-0.1825124,
0.1259245,
0.0538949,
... |
Measurement of glycoprotein content and cell kinetics in preulcerous gastric mucosa. | In an attempt to evaluate the role of gastric mucosal defense factors in ulcerogenesis, we measured the levels of glycoproteins in the mucosa as well as mucosal cell turnover in the preulcerous phase and compared these parameters to the normal mucosa in the same animal. Ovalbumin-presensitized Praomys (Mastomys) natale... | 487,921 | [
0.1155343,
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0.3952573,
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-0.07531755,
0.3113256,
0.1188858,
-0.04278638,
-0.4589472,
-0.0715985,
-0.1791223,
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-0.004183493,
0.1505762,
0.1857982,
0.437184,
0.08912918,
-0.077700... |
Association of cimetidine and bone-marrow suppression in man. | A 29-year old woman who was on steroids for Behcet's disease received intravenous cimetidine for severe gastrointestinal bleeding. A bone-marrow examination performed a few days prior to cimetidine treatment showed a normally active marrow. On the fifth day of cimetidine therapy, agranulocytosis (800/ml) and a very low... | 487,927 | [
-0.1780578,
-0.1592345,
0.05107206,
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-0.08612951,
-0.1183973,
-0.003400355,
0.01671876,
0.1695258,
-0.0003052399,
-0.4445219,
0.1866281,
0.07582955,
0.01058627,
0.2572235,
0.2318484,
0.382829,
-0.08793903,
0.19431... |
[Cold-induced skin damage]. | Two cases of cold-induced skin-damage are reported. In one case cold-induced panniculitis (Adiponecrosis e frigore) in a small child was found. In the other case a Dermo-Hypodermitis in an elderly lady was found, where cold was possibly just one, even if certainly the most important factor of realisation for the diseas... | 487,943 | [
-0.1621732,
-0.309572,
0.1946617,
0.2022893,
0.2713925,
-0.2477409,
-0.40231,
0.1546965,
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0.1059205,
0.1051752,
0.3395143,
0.210656,
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0.2464953,
0.1329935,
0.09580334,
0.2974386,
0.3062833,
-0.0063102,
-0.2327694,
-0.06762... |
[Iodine-induced hyperthyroidism due to contrast media (author's transl)]. | A prospective study in an area with endemic goitre showed 18 patients (15.1%) out of 119 investigated with iodine containing contrast media to be hyperthyroid after 28 days. Oral cholecystography led to the highest (27.9%) and infusion urography to the lowest (5.3%) rate of hyperthyroidism. Determination of the serum c... | 487,949 | [
-0.1287805,
-0.3386867,
-0.2891174,
-0.2207537,
0.2089454,
-0.3127168,
-0.2925008,
-0.1651972,
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0.005802948,
0.1118826,
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0.035108,
0.04003032,
0.5307806,
0.305185,
-0.09389573,
... |
Obstruction of the duodenal bulb caused by gallstone perforation. | Because of acute symptoms in the upper abdomen, upper gastrointestinal endoscopy was performed in a 75-year-old female patient. A large (5 cm x 10 cm) perforated gallstone was embedded in the duodenum, causing complete obstruction of the duodenal bulb. The stone was removed via pylorotomy. A fistula remained between th... | 488,016 | [
-0.180517,
0.1186662,
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0.1216414,
0.1785709,
0.245906,
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0.1172964,
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0.2129038,
0.1024229,
-0.149129,
0.2... |
Industrial emission of cadmium in Japan. | Direct emission of cadmium into air and water in Japan has been controlled on the basis of the Emission and Effluent Standards. Environmental quality in these media has been improved, but delayed effects of these emissions in the past are now manifest by contamination of agricultural acreage in various parts of this co... | 488,033 | [
-0.2701417,
0.03309019,
0.3502538,
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-0.4728962,
0.2171648,
0.3907838,
-0.05510752,
... |
Pulmonary and gastrointestinal exposure to cadmium oxide dust in a battery factory. | The elimination of cadmium in feces was studied in a group of 15 male workers exposed to cadmium oxide dust in a nickel-cadmium battery factory. The elimination of cadmium in feces was on the average 619 and 268 microgram/day in seven smokers and eight nonsmokers, respectively. The corresponding ranges were 97-2577 and... | 488,036 | [
-0.2480432,
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-0.3061929,
0.1146917,
-0.03634669,
-0.1698166,
0.5442315,
-0.00833375... |
Increase in the systolic pressure of rats chronically fed cadmium. | In our laboratory, chronically feeding cadmium to groups of rats has been reproducibly associated with average increases of 15 to 20 mm Hg in systolic pressure. A total of 497 female Long-Evans rats were continuously provided with drinking water fortified with five essential elements and containing from 0.01 to 50 ppm ... | 488,039 | [
-0.223354,
0.2839179,
-0.09059704,
-0.06759895,
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-0.3399906,
-0.196122,
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-0.1659695,
-0.009477835,
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0.1827897,
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0.1934322,
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0.0605544,
-0.3066398,
0.3103151,
0.05386761,
... |
Studies on cadmium-induced inhibition of hepatic microsomal drug biotransformation in the rat. | Cadmium is a potent inhibitor of hepatic microsomal drug biotransformation in the rat. Male rats receiving a single intraperitoneal dose of cadmium exhibit significant decreases in hepatic microsomal metabolism of a variety of substrates. The threshold cadmium dose is 0.84 mg Cd/kg, and the effect lasts at least 28 day... | 488,042 | [
-0.1533225,
-0.2221603,
-0.1725106,
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-0.03587178,
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0.1184493,
-0.1058587,
0.003536493,
-0.07944801,
0.3943744,
-0.0719... |
Cadmium uptake from feed and its distribution to food products of livestock. | Distribution of cadmium (Cd) into the edible products of three species of food-producing animals was investigated during long-term dietary administration of supplemental cadmium chloride. Cows were exposed to 0.2 (control), 2.4, and 11.3 ppm Cd on whole ration basis for a period of three months followed by a three-mont... | 488,049 | [
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-0.04870891,
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-0.1581921,
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0.1601903,
0.1707863,
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-0.417999,
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-0.4427625,
-0.01336756,
-0.1003678,
0.06422895,
0.07066771,
0.5776908,
-0.0631126... |
A new spectrophotometric assay for enzymes of purine metabolism. I. Determination of xanthine oxidase activity. | A new method for the determination of xanthine oxidase activity with xanthine or hypoxanthine is described. The hydrogen peroxide produced by the oxidation of the substrates is reduced by catalase in the presence of high concentrations of ethanol. The acetaldehyde formed is further oxidized by aldehyde dehydrogenase NA... | 488,056 | [
-0.07575219,
0.05941717,
-0.2053361,
0.296525,
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0.1828252,
0.08770119,
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0.09153448,
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0.2715573,
0.03042976,
0.2635285,
-0.01293592,
... |
Plasma noradrenaline response to sustained handgrip in patients with essential hypertension. | The responses of plasma noradrenaline, arterial blood pressure, and heart rate to sustained handgrip at 30% maximal voluntary contraction were studied in untreated patients with essential hypertension and in healthy subjects of comparable age. There were no significant differences between these two groups in the intens... | 488,083 | [
-0.2996242,
0.3990936,
-0.4439455,
-0.188418,
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-0.4273884,
-0.09252831,
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-0.02841254,
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0.05554014,
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0.0635768,
0.177368,
... |
[Characterisation of a new endopeptidase from sporulating Bacillus sphaericus which is specific for the gamma-D-glutamyl-L-lysine and gamma-D-glutamyl-(L)meso-diaminopimelate linkages of peptidoglycan substrates (author's transl)]. | A new peptidase which splits substrates related to the peptidic chains of peptidoglycans was found in the cell cytoplasm of sporulating Bacillus sphaericus. This is a gamma-D-glutamyl-L-diaminoacid endopeptidase (endopeptidase II). It was shown to have substrate requirements different from those of the previously descr... | 488,088 | [
0.06681091,
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-0.1192762,
0.3403174,
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0.1783123,
0.563897,
0.07825223,
-0.06523419,
0.... |
A comparison of the initiation factors of eukaryotic protein synthesis from ribosomes and from the postribosomal supernatant. | A purification procedure is described for the initiation factors of protein synthesis from rabbit reticulocytes: (a) from the ribosomal wash and (b) from the postribosomal supernantant. A comparison is made between these preparations with respect to yield and specific activity. eIF-4A and eIF-4D occur mainly in the pos... | 488,105 | [
0.08330965,
0.3216785,
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0.02398712,
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0.03985768,
0.2458653,
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-0.06090683,
-0.2705704,
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0.05300391,
-0.01165315,
0.2106895,
0.2258288,
0.3025353,
-0.0091599... |
Amino acid sequence of the aminoterminal segment of dermatosparactic calf-skin procollagen type I. | The N-terminal procollagen peptide of the pN alpha 1(I) chain from dermatosparactic calf skin contains 139 amino acid residues. For the determination of the amino acid sequence the procollagen peptide was treated with pyroglutamate aminopeptidase, protease from Staphylococcus aureus V8 and trypsin. The fragments obtai... | 488,118 | [
-0.00934661,
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0.008966399,
-0.06962308,
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0.03964304,
0.05915033,
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0.3402729,
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-0.2574918,
0.02821318,
0.02848622,
-0.1049237,
0.02993149,
0.1751308,
-0.2321... |
A rare genetically determined variant of psuedocholinesterase in two German families with high plasma enzyme activity. | Activity of pseudocholinesterase (acylcholine-acyl-hydrolase) elevated up to four times has been detected in sera of members of two German families. The catalytic concentrations of the pseudocholinesterase of the afflicted members of both families (male and female) varied between 4800 U/l and 10 200 U/o (acetylthiochol... | 488,119 | [
-0.2586016,
-0.01128769,
-0.07175737,
-0.1997307,
0.04354958,
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-0.2151603,
-0.03456404,
-0.1458385,
0.2094985,
0.2082982,
0.1882982,
0.1502575,
0.04096112,
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-0.3272593,
0.1645868,
-0.0720671,
0.3598509,
-0.03038638,
0.4329892,
-0.1056289... |
Diagnostic validity for different components of pattern shift visual evoked potentials in multiple sclerosis. | Visual evoked potentials, elicited by checkerboard-pattern reversal were recorded from multiple sclerosis patients with different probabilities of diagnosis. Latencies and amplitudes of the different components were analyzed for diagnostic validity. It was demonstrated that the latency of the main positive peak (P2) wa... | 488,142 | [
-0.04776423,
-0.1025406,
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-0.02582722,
-0.0259463,
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0.04327277,
-0.0761405,
-0.1323437,
-0.277173,
-0.6192959,
0.162201,
-0.04928487,
-0.1429221,
-0.0696595,
0.3058545,
0.2057519,
... |
Capillary circulation and morphology in Duchenne muscular dystrophy. | Muscle blood flow (MBF) and capillary diffusion capacity (CDC) were determined in 8 patients with Duchenne muscular dystrophy and 5 age-matched control males by measuring the simultaneous clearance of 133Xe and 131I-. MBF was significantly decreased in older patients with severe dystrophy: 35.1 +/- 5.8 ml/100 g/min in ... | 488,143 | [
-0.1959405,
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0.1324655,
0.1013996,
... |
Ephaptic recurrent response in man. | The antidromic impulse associated to the ephaptic response can produce a recurrent wave (Fe). Its latency, which is longer than that of the F wave, will augment if the site of stimulation is remote from the muscle. It is therefore a direct-indirect response. The 'Fe' wave is similar to the 'S' response described by Tho... | 488,144 | [
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0.2951913,
-0.04460509,
-0.1448751,... |
Ephaptic response in man. | Following the direct M response, peripheral nerve stimulation frequently evokes a second wave which shows all characteristics of an ephaptic response. The antidromic impulse or back response, which is always associated, is detected by a double stimulation technique. The ephaptic response seems not to be related to any ... | 488,145 | [
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0.03695115,
0.4363531,
0.1667242,
0.12301... |
Free fatty acid and glucose metabolism during hypothermic perfusion of canine kidneys. | Canine kidneys were subjected to continuous nonpulsatile perfusion using 200 ml of a perfusate containing 50 g/l albumin. When optimal oxygenation was achieved, perfusate K+ contents were unchanged for 24 h, indicating adequate membrane function but tended to increase thereafter. Lowered oxygen pressures resulted in si... | 488,147 | [
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0.05329797,
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0.2007249,
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0.1... |
Assay for thrombopoietin: a comparison of time of isotope incorporation into platelets and the effects of different strains and sexes of mice. | Several workers have used mice for thrombocytopoiesis-stimulating factor (TSF) assays, but the methods have differed. In quest of the optimum TSF assay conditions, we investigated the effects of interval between isotope injection and measurement of 35S incorporation into platelets, different mouse strains and sexes of ... | 488,187 | [
-0.1274579,
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0.09046686,
0.06518579,
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... |
Comparison of dynamic properties of canal-evoked vestibulospinal reflexes of the neck and forelimb in the decerebrate cat. | The responses of neck and forelimb muscles to sinusoidal polarization of the horizontal canal nerve were compared by recording from these muscles simultaneously. Contrary to results on the vestibulocollic reflex, the central phase lag in the vestibulo-forelimb reflex increases with increasing frequencies up to 3 Hz. Th... | 488,209 | [
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0.0755163,
0.151097... |
A visual stimulator for orbiting light spots and equal energy annuli with continuously variable parameters. | When a light spot moves at high angular velocity along a circular path on a screen, an annulus is preceived. This principle is used in a simple annulus generator consisting of a plane mirror that rotates about an axis making an angle alpha with the normal in the center point of the mirror. Angle alpha can be varied wit... | 488,218 | [
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-0.135391,
0.3911192,
-0.08966012,
0.0421532... |
GFA expression in aggregation cultures of rat C6 glioma. | Few C6 glioma cells synthesize the astroglia-specific GFA protein in monolayer culture. A uniform population of GFA-positive cells was obtained by aggregation C6 cells in suspension culture, as previously reported for C6 glioma maintained on sponge foam matrices. These results strongly suggest that cell-to-cell interac... | 488,267 | [
-0.04420168,
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0.04167354,
0.0078... |
Interaction between human evoked electrospinograms elicited by segmental and descending volleys. | Interaction between the slow negative-positive waves of human evoked electrospinograms produced by descending and segmental volleys was tested under general anaesthesia. A partial occlusion was demonstrated in these slow waves. | 488,277 | [
0.1636111,
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0.1251982,
... |
Electrophysiology of mammalian hypothalamic and interpeduncular neurons in vitro. | Electrical activities of the hypothalamic and interpeduncular neurons were studied in vitro in brain slices prepared from the guinea-pig brain stem. Neurons preserved resting membrane potentials comparable to those of neurons in vivo, responded to stimulation of the afferent fibres, and retained stable spontaneous firi... | 488,278 | [
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0.1060144,
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0.1337311,
0.1813407,... |
Receptor potential of rat taste cell to potassium benzoate. | Rat taste cells responded to relatively low concentrations of K-benzoate with a hyperpolarization and to the high concentrations with a depolarization. During both responses the membrane resistance of a taste cell decreased. Depolarization elicited by application of a combination of 0.25 M NaCl and 0.05 M K-benzoate wa... | 488,279 | [
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0.1993051,
0.04220959,
0.242841,... |
Severe conditioned taste aversion elicited by venom of Russell's viper. | Conditioned taste aversion (CTA) established in rats by associating saccharin drinking with subsequent poisoning by Russell's viper venom. Retention test revealed 76 and 56% reduction of saccharin intake in venom and antivenom-venom groups. No CTA was observed in antivenom and control groups. | 488,281 | [
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The localization of [3H]-desipramine in central nerve terminals studied with electron microscope autoradiography and subcellular fractionation. | The cellular and subcellular distribution of [3H]-desipramine (DMI) in rat brain was studied by electron microscope (EM) autoradiography and by subcellular fractionation. A considerable proportion of label was found to be bound to the membranes of presynaptic nerve terminals, as well as to sites inside those terminals. | 488,282 | [
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0.1102701,
0.1930963,
0.2701912,
0.1021441,
... |
Purification and properties of heat-resistant exotoxin produced by Macrophomina phaseolina (Tassi) Goid in culture. | A partially purified preparation of a water-soluble, heat-resistant, nonspecific exotoxin produced by a strain of Macrophomina phaseolina, isolated from Phaseolus mungo L. could reduce Cu++ ions and produced a red colour with 2,4-dinitrophenyl hydrazine reagent. It caused inhibition of seed germination, wilting of cult... | 488,287 | [
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0.1364335,
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0.2133546,
-0.4622995,
0... |
Ultrastructural localization of vanadium in the blood cells of Ascidiacea. | X-ray histospectrographic analysis at the scanning and transmission electron microscope (STEM) are made on the blood cells of Phallusia mamillata Cuvier and Ciona intestinalis, to study the 'direct' intracellular sites of accumulation of vanadium. The results show a clear accumulation of vanadium on the membrane and in... | 488,290 | [
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0.03377379,
0.2133233,
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0.491974,
0.2235048,
0.1292311,
-... |
Nuclear localization of aldosterone in rat brain cells assessed by autoradiography. | Autoradiographic studies with 3H aldosterone demonstrate nuclear concentration of hormone in neurons of the hippocampus, septum, allocortical regions and brain stem reticular formation and motor nuclei of cranial nerves and in the meninges. The results suggest that mineralocorticoids have wide ranging effects on differ... | 488,294 | [
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0.... |
Family therapy as a treatment for children: a critical review of outcome research. | The value of family therapy as a treatment for child psychopathology is considered by reviewing pertinent outcome research. Fourteen studies that met three criteria are included in the review: (a) a child or adolescent was the identified patient or referral; (b) therapy included at least one parent and the child; and (... | 488,314 | [
-0.2115228,
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-0.008847217,
... |
[Effect of neurotropic agents on the healing of experimental mucosal erosions and on the noradrenaline content in the stomach wall]. | In immobilized rats with hemorrhagic erosions of gastric mucosa induced by 8-hour electric stimulation, the neurotropic agents were injected intraperitoneally over three days after stimulation was discontinued. Phenamine and melipramine were conductive to healing of the mucous membrane erosions and produced no effect o... | 488,317 | [
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0.1215646,
0.0459107,
-0.2074141,
-0.1208505,
... |
An analysis of macrosurgical and microsurgical techniques in the management of the tuboperitoneal factor in infertility. | One hundred and sixty tubal reconstructions were analyzed according to a classification which describes the type of tubal repair and the tubal segment treated. The results in 80 women who were operated upon just prior to the application of microsurgical principles were compared with those in 80 women in whom these tech... | 488,422 | [
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0.2000335,
0.3091185,
0.1612034,
0.... |
Effect of prednisone on plasma testosterone levels and on duration of phases of the menstrual cycle in hyperandrogenic women. | A group of 106 women of reproductive age with laboratory and clinical evidence of hyperandrogenism was treated with prednisone. The daily dosage varied between 7.5 and 10 mg. Ovulatory activity was assessed prior to and during therapy by basal body temperature and observation of changes in the cervical os and cervical ... | 488,427 | [
0.03324537,
0.03043371,
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0.0776618,
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0.1174945,
0.2934924,
0.2449927,
-0.01154753... |
[Correlation between nonspecific and specific excitation in the cat somatosensory cortex during different modalities of stimulation]. | Multiunit activity and EEG recorded with the same electrode from the somatosensory cortex in unrestrained cats, were compared. The obviously identical patterns of the EEG activation coincided with different multiunit patterns (acceleration or deceleration of frequency, modification of discharge order) depending on the ... | 488,445 | [
-0.08250483,
0.2726728,
0.08109631,
0.09643981,
0.1613042,
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-0.05794918,
-0.03650963,
-0.0694242,
0.... |
Norway rat haemoglobin phenotypes: which is the original? | On the basis of the incidence of haemoglobin alleles in different populations of rats, the hypothesis is discussed that the HbbB is phylogenetically "older". | 488,467 | [
0.02013117,
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0.04302439,
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0.3068088,
0.08670389,
0.007766069,
0.3444653,
-0.1905676... |
[Alimentary nickel and contact eczema (author's transl)]. | By atomic absorption spectrometry, nickel was analysed in many foodstuffs. The results of these determinations are given in detail. Nickel present in vegetables comes primarily from the soil but secondarily from stainless-steel cooking utensils. | 488,494 | [
-0.04577977,
0.0185719,
0.1411691,
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0.1097697,
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0.2278429,
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0.008698385,
0.214776,
0.2814861,
0.01561469,
... |
[Delayed hypersensitivity against staphylococcal antigens in guinea pigs (author's transl)]. | Delayed type hypersensitivity against staphylococcal antigens could be induced in guinea pigs by injecting the animals with a staphylococcal homogenate in Freund's adjuvant in all four foot pads and the nuchal skin. Maximal skin reactivity, tested intracutaneously, was observed 21 days after sensitization. Highest stim... | 488,496 | [
0.0098872,
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0.05433345,
0.2182547,
0.2393551,
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0.04723308,
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0.1088932,
0.002186952,
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0.004158706,
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0.466514,
0.462706,
0.04414289,
-0.1120322,
-... |
[Clinic and treatment of porphyria cutanea tarda (author's transl)]. | Symptomatology and pathogenesis of porphyria cutanea tarda (PCT) are shortly reviewed. The different possibilities in the treatment of PCT are discussed with special reference to the phlebotomy according to Ippen and to the chloroquine administration according to the regimen described by Kordac and Semradova in 1974. 7... | 488,497 | [
0.2232641,
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0.170293,
0.01828393,
0.3272678,
-0.02511235,
-0.1202791,
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-0.... |
Postnatal undernutrition in rats: attempts to develop alternative methods to food deprive pups without maternal behavioral alteration. | Two methods were investigated as attempts to undernourish rat pups without the disturbances in maternal behavior that accompany the procedures used to date for this purpose. In the 1st method, a litter of 12 pups was raised by both a lactating mother and a "sensitized" female. The sensitized female was provided under t... | 488,531 | [
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-0.2243271,
0.1327748,
0.1879647,
... |
Deficits in fixed-interval performance following prenatal and postnatal lead exposure. | Female rats were exposed daily to 750 mg/kg of lead acetate via a restricted watering schedule for 70-80 days prior to mating and then throughout pregnancy and nursing. At weaning, litters from half of the lead dams were placed directly on treatment for the duration of the experiment. These manipulations yielded 3 grou... | 488,533 | [
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0.09796741,
0.0241404,
0.3829501,
0.01821596,
-... |
Long-term effects of preweaning taurine injections in rats: interactions with strain and gender. | A comparison was made of MR, MNR, and RCA strains that had been injected with either 62.5 mg/kg of taurine or comparable volumes of physiological saline between postnatal Days 8 and 20 and later tested at 100 days of age in an open field and 1-way shock avoidance situations. Taurine-injected rats displayed significant ... | 488,534 | [
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0.05558525,
-0.3727474,
-0.08575981,
0.1153478,
-0.03903672,
0.046643... |
Effect of acetate on hypoglycemic seizures in mice. | In order to determine the effects of acetate on signs and symptoms of hypoglycemic seizures, Swiss Webster albino mice were injected intraperitoneally with solutions of NaCl, NaHCO3, NH4Cl, Na-acetate, or NH4-acetate, followed by subcutaneous injection of 7 U of insulin/kg body wt. Administration of Na- or NH4-acetate ... | 488,541 | [
-0.128625,
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0.1299828,
0.07193155,
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Effect of experimental hyperinsulinaemia on intracellular glucose metabolism of isolated adipocytes. | Glucose oxidation and lipogenesis were studied in isolated adipocytes from control and non-obese, experimentally hyperinsulinaemic rats. In cells from the hyperinsulinaemic animals oxidation of either [1(-14) C]- or [6(-14) C] glucose was increased in the presence or absence of insulin, at substrate concentrations from... | 488,566 | [
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0.1353548,
0.07450127,
0.288763,
0.01261472,
0.3654481,
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Delayed esophageal perforation after pneumatic dilatation for the treatment of achalasia. | Two cases of delayed esophageal perforation following a pneumatic dilatation for the treatment of achalasia are presented. Esophagrams obtained immediately after pneumatic dilatation failed to reveal a perforation. Increasing symptoms prompted repeat contrast studies, at which time an esophageal perforation was demonst... | 488,607 | [
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0.2523931,
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0.1... |
Enterocylsis: the small bowel enema. How to succeed and how to fail. | Enteroclysis, the infusion of contrast medium directly into the small bowel, is a precise, rapid method for thorough small bowel examination. This technique demonstrates far more pathology than any other method when it is properly executed. However, the examination is sure to fail with poor techniques, thereby discredi... | 488,620 | [
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0.3968686,
0.1364184,
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... |
Role of plasma histamine in liver injury--clinical and experimental investigations. | Plasma histamine level (PHL) was evaluated by a modified fluorometric assay (Suzuki) in the patients with various forms of liver disease as well as rabbits with liver injury. And the data obtained were compared with liver function tests in assessing the stage and prognosis of hepatic dysfunction. In acute hepatitis, if... | 488,624 | [
-0.04282716,
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0.4175731,
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0.1613062,
0.07465545,... |
Enterogastric reflux in normal subjects and patients with Bilroth II gastroenterostomy. Measurement of enterogastric reflux. | Initially, scintigraphy was established as a valid method for detecting and quantitating enterogastric reflux. A new, tubeless technique for the measurement of enterogastric reflux was developed. 99mTc bound to [(2,6 dimethylphenylcarbamoylmethyl) iminodiacetic acid] (5 mCi) was administered intravenously to visualize ... | 488,630 | [
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0.006630879,
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0.03982929,
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0.07776093,
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0.1504039,
0.1721689,
0.1846665,
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0.3399126,
-0.153379,
0.1290543,
0.6963691,
0.0718048,
0.1899495,
0.2... |
Griseofulvin-induced cholestasis in Swiss albino mice. | Griseofulvin was fed to male Swiss albino mice, which were sacrificed at varying times after the initiation of the feeding. The following were compared with mice fed a control diet: hepatic histology, hepatic weight, plasma glycocholate, glycolithocholate, cholesterol, bilirubin, and alkaline phosphatase. Concurrent wi... | 488,635 | [
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0.1796999,
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0.1655338,
0.02362296,
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0.356443,
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0.1149382,
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0.123114,
0.06295773,
0.07413895,
-0.08151011,
-0.08929621,
0.02939052,
... |
Percutaneous pancreatography: case report and presentation of technique. | A case of traumatic pancreatitis with a radiopaque calculus producing pain by obstructing the distal pancreatic duct is presented. Preoperative ductal anatomy was defined by a percutaneous pancreatogram that established the presence of mechanical duct obstruction as the cause of pain, and the potential for operative re... | 488,636 | [
0.1611731,
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0.07874455,
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0.2570959,
0.1827043,
0.2740951,
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0.08788313,
0.1215929,
0.241651,
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0.1423501,
0.01328185,
0.03847515,
... |
Population genetics of Drosophila amylase. I. Genetic control of tissue-specific expression in D. pseudoobscura. | Drosophila pseudoobscura is polymorphic for tissue-specific expression of alpha-amylase in adult midguts. This enzyme is encoded by a single locus, Amy, on the third chromosome. In this paper we show: (1) Up to about 12 days post-eclosion, the midgut activity patterns remain stable; after 12 days areas not showing acti... | 488,706 | [
0.02086965,
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0.09598503,
0.09317663,
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0.1890065,
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0.302127,
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0.02101744,
0.08240151,
-0.06118853,
0.2850706,
0.1491482,
-0.1069505... |
Comparative findings on body size of children and youths living at urban centers and in rural areas. | The focus of this paper is on rural-urban differences in human body size during the period between ages 8 years and 15 years. Groups of village and city residents are compared on standing height, body weight, and other somatic dimensions. Wide variation is found: from data collected during 1955--1972, urban children an... | 488,749 | [
0.173367,
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-0.1675621,
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0.04340577,
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0.17126,
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0.01211581,
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-0.02817513,
0.1675025,
0.2111326,
0.04748388,
0.0275866,
0.2738625,
-0.09209297,
0... |
Enzyme activities and morphological appearance in functioning and excluded segments of the small intestine after shunt operation for obesity. | Five patients in whom small-intestinal bypass was performed for severe obesity had a second operation 11-19 months later because of insufficient weight loss. Mucosal enzyme activities and histological appearance were investigated in biopsies from different parts of the functioning and excluded small intestine. These we... | 488,750 | [
0.2575018,
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0.1614627,
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0.07736768,
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0.0124781,
0.3025041,
0.1684543,
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0.0352824,
0.07130653,
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0.2865819,
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-0.03826892,
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0.3192241,
0.1527148,
0.2610323,
-0.1156664,
-0.... |
Bilateral ulnar "thumbs". | Congenital fusion of the carpal bones is fairly common and may be associated with other congenital deformities in the hand. This report deals with an unusual congenital anomaly of the little fingers associated with fusion of the triquetrum and lunate. Both little fingers were adducted and rotated giving crude resemblan... | 488,785 | [
-0.1312658,
0.347003,
0.03210357,
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0.1340766,
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0.3789434,
0.1178979,
0.2683104,
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0.1810275,
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0.1427989,
0.07072733,
-0.0846771,
... |
Extensor digitorum brevis manus: a case report review. | A detailed description of bilateral extensor digitorum brevis manus (EDBM) present in a female cadaver is presented. The need for clinical recognition is emphasized. Prevalence, morphological variability and theories of ontogeny are reviewed. Clinical significance and possible function are discussed. Since misdiagnosis... | 488,800 | [
-0.2075578,
0.08886667,
-0.1237943,
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0.06090707,
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0.03763169,
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0.2263779,
0.1090392,
0.1167113,
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0.3018072,
-0.1740524,
-0.20305,
0.1603459,
0.2732193,
-0.1166746,
... |
Are social workers turning a deaf ear? A study of social services to the deaf. | This study assessed the quality and quantity of social services received by deaf persons residing in Salt Lake County, Utah. It was found that although a majority of human service agencies in the county have had some contact with deaf clients, only those agencies that have made an effort to develop programs especially ... | 488,842 | [
-0.05694347,
0.2675184,
-0.09434788,
-0.09891474,
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0.2197609,
0.3018847,
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0.05102568,
0.1110228,
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-0.3704108,
0.1228134,
-0.06133067,
-0.272825,
-0.09017011,
-0.1358476,
-0.2503971,
-0.307901,
0.1918268,
0.05633815... |
Group work in a hospital waiting room. | For students who have determination, field-work placements offer an opportunity not only to learn, but to develop innovative services. The authors give a personal account of how, as students, they initiated a program of group work in a hospital waiting room. | 488,847 | [
-0.03171223,
0.08397409,
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0.26958,
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0.1001429,
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0.1818111,
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0.2645318,
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0.05017899,
0.1271126,
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0.06467765,
0.004652334,
0.3529494,
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... |
Quantitative histochemistry of the sorbitol pathway in glomeruli and small arteries of human diabetic kidney. | Recent evidence has suggested a role for the polyol pathway in pathogenesis of cell damage in diabetes Glucose may be phosphorylated to glucose-6-phosphate via hexokinase and enter glycolysis or reduced to sorbitol via aldose reductase to enter the polyol pathway. The poorly diffusible sorbitol is converted via sorbito... | 488,851 | [
-0.2495382,
-0.09811569,
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0.123976,
0.2701211,
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0.05816535,
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0.1067218,
0.1669437,
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0.2053161,
0.3253524,
0.3625473,
0.123537,
0.584552,
-0.1203157,
0.0... |
An improved method for the determination of cytoplasmic 3 alpha- and 17 beta- and microsomal 3 alpha-hydroxysteroid dehydrogenase activities in rat liver. | This paper described a modified method for the radiometric determination of hydroxysteroid dehydrogenase activities in rat liver. The principle advantages of this method are the improved precision and a radical reduction in the time involved in performing the assay. The procedure comprises the following steps: incubati... | 488,914 | [
-0.02289299,
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-0.3439384,
-0.1635433,
-0.02753617,
0.4187948,
0.297972,
0.4707432,
-0.064892... |
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