title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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A review of the behaviour of chondrosarcoma of bone. | Sixty-two cases of chondrosarcoma of bone were reviewed and histologically graded as low, medium or high-grade tumours. After excluding patients dead from unrelated causes or lost to follow-up, forty cases were available for ten-year follow-up and fifty-eight for five-year follow-up. The rates of survival, recurrence a... | 500,746 | [
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Tarsal hypermobility after ankle fusion--fact or fiction? | Thirty-seven patients have been reviewed after arthrodesis of the ankle in order to determine the reduction of dorsiflexion and plantarflexion of the foot, the incidence of tarsal hypermobility and its relevance to the clinical results of this procedure. Radiological methods of measuring movements in the foot and tarsu... | 500,759 | [
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Relapsing club feet. Late results of delayed operation. | The operation of soft-tissue release and calcaneocuboid fusion, published by Dillwyn Evans in 1961, is described in detail and a long-term review of 118 club feet is presented. The average age of the patients at review was nearly seventeen years. All were resistant cases and in all the Dillwyn Evans "collateral operati... | 500,760 | [
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Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells. | A methotrexate (MTX)-resistant murine lymphoblastoid cell line has been obtained by serial passage in increasing concentrations of MTX which is greater than 100,000-fold resistant to MTX (L5178YR) and has dihydrofolate reductase (DHFR) levels 300-fold higher than the parental line. The L5178YR cell line synthesizes app... | 500,787 | [
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Mesangial function in ureteral obstruction in the rat. Blockade of the efferent limb. | The kinetics for mesangial uptake and transport of radiolabeled aggregated human immunoglobulin (Ig)G (AHIgG(125)I) deviated markedly from normal in male Sprague-Dawley rats with ureteral obstruction. Four experimental groups, each containing 25 rats, were used: (a) bilateral ureteral ligation (BUL) with release of one... | 500,807 | [
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Induction of ouabain-resistant mutation and sister chromatid exchanges in Chinese hamster cells with chemical carcinogens mediated by human pulmonary macrophages. | Pulmonary macrophages (PAM) metabolically activated benzo[a]pyrene [B(a)P] and its proximate carcinogenic metabolite, (+/-)trans 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (7,8-diol), to ultimate mutagens that were detected in cocultivated Chinese hamster V79 cells. Increases in the frequency of ouabainresistant (O(r)) mu... | 500,808 | [
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Binding of 125I-insulin to the isolated glomeruli of rat kidney. | To investigate a possible action of insulin on the glomerulus, the binding 125I-insulin to the isolated glomeruli prepared from rat kidney was examined. When incubated at 22 degrees C, 125I-insulin binding proceeded with time and reached a steady state at 45 min at which time nonspecific binding was less than 25% of to... | 500,816 | [
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Inhibition by propionyl-coenzyme A of N-acetylglutamate synthetase in rat liver mitochondria. A possible explanation for hyperammonemia in propionic and methylmalonic acidemia. | In the search for the mechanism by which hyperammonemia complicates propionic and methylmalonic acidemia the effects of a series of acyl-coenzyme A (CoA) derivatives were studied on the activity of N-acetylglutamate synthetase in rat liver mitochondria using acetyl-CoA as substrate. Propionyl-CoA was found to be a comp... | 500,823 | [
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Ethylmalonic-adipic aciduria. In vivo and in vitro studies indicating deficiency of activities of multiple acyl-CoA dehydrogenases. | The mechanisms underlying ethylmalonic-adipic aciduria were studied in a 5-yr-old girl. Oxidation of radioactive substrates by cultured skin fibroblasts from the proband and asymptomatic family members was also determined and compared to that by normal fibroblasts and that by cells from a patient with glutaric aciduria... | 500,826 | [
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A new chromogenic assay for the specific determination of prothrombin. | A new method for the specific assay of prothrombin is described which utilises Taipan snake venom and the chromogenic substrate Tos-Gly-Pro-Arg-pNA (Chromozym TH). The method is sensitive and reproducible and shows good correlation with a conventional specific assay for prothrombin. The reaction is dependent on calcium... | 500,835 | [
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The development of vibrissae representation in subcortical trigeminal centers of the neonatal rat. | In every station of the trigeminal system of the young rat, the segmented activity of the mitochondrial enzyme succinic dehydrogenase (SDH) clearly delineates the representation of the mystacial vibrissae. In the trigeminal complex of the medulla, three parallel representation can be seen, two in the spinal trigeminal ... | 500,854 | [
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Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy. | Rods and cones of the C57BL/6J mouse retina have been examined by light and electron microscopy to distinguish the structural features of the two photoreceptor types. By light microscopy, cone nuclei are conspicuously different from rod nuclei in 1-2 micrometer plastic sections. Cone nuclei have an irregularly shaped c... | 500,858 | [
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Alarm reaction of pilosebaceous apparatus. | A series of histologic changes involving the pilosebaceous structures are described under the term "alarm reaction." The follicular manifestation of this phenomenon is characterized by regression of hair matrix, forming a well-defined nest of small basaloid cells found in various parts of the follicular canal. The seba... | 500,867 | [
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Dermal duct tumor. | A dermal duct tumor which clinically resembled an intradermal nevus and developed on the lower back of a 59-year-old woman is described. The diagnosis could only be reached by microscopic examination. The dermal duct tumor appears to originate from cells with differentiation towards the intradermal portion of the eccri... | 500,879 | [
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Scalp reduction for alopecia. | A 17-year-old boy had a large, scarred area of alopecia from a thermal burn. Forty square centimeters of scarred scalp skin were excised in six sessions. The cosmetic result was excellent. Neither hypertrophic nor keloidal scarring supervened. The technique of scalp reduction and its procedure as an adjunct to hair tra... | 500,928 | [
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Study of right ventricular function in ischaemic heart disease using radionuclide angiocardiography. | A technique for the estimation of LVEF from first passage radionuclide angiocardiography was adapted to provide estimates of RVEF. In 17 subjects with no history of cardiovascular disease mean LVEF was 0.71 +/- 0.08 and mean RVEF 0.65 +/- 0.08. Mean values for 15 subjects with coronary artery disease but no previous hi... | 500,940 | [
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Haemodynamics in phaeochromocytoma. A report of 2 cases. | The haemodynamic measurements made in two cases of proved phaeochromocytoma are described. In both the systemic vascular resistance (SVR) was markedly increased and was associated with a decreased preload. In one case, phentolamine infusion, when lowering the SVR, produced a marked decrease in the cardiac index resulti... | 500,944 | [
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Program evaluation for effective resource management and accountability. | A means of determining the effectiveness of public programs as a basis for justifying resource allocation to these programs is urgently needed. Program evaluation can provide the data base required for program decision-making and modification. A ten-step model for planning and carrying out an evaluation is suggested as... | 500,986 | [
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Diagnostic outcomes of optometric referrals in a VA medical center. | 408 conditions affecting the visual system of patients presenting in the optometry clinic of the Birmingham Veterans Administration Medical Center (BVAMC) were referred to other providers within the medical center for care outside the scope of optometric responsibility. Rates of compliance and confirmation are given fo... | 500,996 | [
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Do patients really want cheap lenses? | There is a strong possibility that many patients perceive newspaper advertisements as a sign of dependability or prestige rather than the evidence of unethical behavior that professionals traditionally frown upon. "Confidence in the doctor" was the foremost reason given for seeking professional service in a survey by a... | 501,009 | [
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Getting the message across. | Messages do not simple 'get across'. The author points out the importance (1) of seeing good communication as an effort of understanding between human beings and (2) of dismissing any idea of a single communicator's skill. There are many and different skills to be applied. | 501,077 | [
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Changes in carbohydrate expression of lichen planus affected oral epithelial cell membranes. | The purpose of the present study was to examine possible epithelial cell membrane changes in lichen planus affected oral mucosa by the use of the lectins concanavalin-A and ricinus communis agglutinin fraction I. It was shown that these lectins in contrast to what was found in normal epithelium do not bind to the cell ... | 501,134 | [
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Specific binding of prostaglandin E2 to membrane preparations from human skin: receptor modulation by UVB-irradiation and chemical agents. | Human skin membranes bind prostaglandin E2 (PGE2) with high affinity (with an apparent dissociation constant, Kd, of 3.14 X 10(-9) M) and specificity. This binding is inhibited by trypsin or heat treatment suggesting that PGE2 receptors have protein components. Exposure of the membranes to ultraviolet irradiation (UVB)... | 501,135 | [
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Augmentation of peritoneal mass transport by dopamine: comparison with norepinephrine and evaluation of pharmacologic mechanisms. | The effect of catecholamines on transport during peritoneal dialysis was studied in unanesthetized rabbits. Intravenous I-norepinephrine consistently decreased peritoneal clearances of urea and creatinine to 84% of control values or less but did not affect osmotically induced water flux. Comparable pressor doses of dop... | 501,201 | [
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Improved gas chromatographic quantitation of breath hydrogen by normalization to respiratory carbon dioxide. | A gas-solid chromatographic system using tandem silica gel and molecular sieve columns is described for the measurement of hydrogen, carbon dioxide, oxygen, and nitrogen in samples of respiratory gases. This system has a detection limit of 2 ppm of hydrogen in a 1 ml sample and can measure 120 ppm H2 and 5% CO2 with re... | 501,202 | [
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Enzymic assay of plasma cholesterol: a comparison of analytical variations found using the Greiner GSA II and the Technicon SMA 12/60 and SMA II. | Cholesterol was assayed on the Greiner GSA II and the Technicon SMA 12/60 and SMA II autoanalyzers, with Allain's entirely enzymic method (Allain et al. (1974), Clin. Chem. 20, 470--475). The coefficients of variation in the results over a period of one month were less than 6% with the GSA II and the SMA II, but up to ... | 501,301 | [
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Interferon induction by viruses. II. Sindbis virus: interferon induction requires one-quarter of the genome--genes G and A. | We have measured the amounts of interferon formed by chick cells 'aged' in vitro in response to different amounts of infectious wild-type Sindbis virus. Our results suggest that one plaque-forming unit is enough to induce maximum interferon formation. With higher m.o.i. the yield of interferon is less. To inactivate th... | 501,335 | [
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Ribonuclease activity of preparations of human lymphoblastoid interferon. | Crude human lymphoblastoid interferon has less ribonuclease activity than equivalent primary leukocyte interferon and ribonuclease was eliminated when it was purified. The methods used differed from those that had failed to eliminate similar activity from leukocyte interferon. This result makes it unlikely that exogeno... | 501,337 | [
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0.2179414,
0.2172509,
0.04374023,
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-0.2224002,
-0.03283129,
0.485209,
0.1972575,
-0.01133466,
-0.0755881... |
Plasma dopamine beta hydroxylase (D.B.H.) activity in Parkinsonian patients under L-dopa, and 2-bromo-alpha-ergocriptine loading. | Dopamine-Beta-Hydroxylase (D.B.H.)-activity was measured in the plasma of untreated Parkinsonian patients, after tretment with L-dopa and 2-Bromo-alpha-ergocriptine. The findings were compared to the D.B.H.-activity of a matched healthy control group. After L-dopa loading D.B.H.-activity decreased in the Parkinsonian p... | 501,350 | [
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0.4139791,
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Inverted knee jerk: a neglected localising sign in spinal cord disease. | Two cases are described in which inversion of the quadriceps jerk was observed. It is suggested that the finding of an inverted quadriceps jerk is evidence of a spinal cord lesion at 12, 3, 4 segmental level and has for the lumbar cord the same localising value as the inverted supinator jerk for the cervical cord. | 501,364 | [
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... |
Memory in functional psychosis. | Acute schizophrenic, chronic schizophrenic, and depressive patients (20 of each) were compared with normal subjects and six groups of patients with organic brain disease. They were given tests of verbal learning (left hemisphere type function) and pattern recognition memory (right hemisphere type function). All functio... | 501,367 | [
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0.122534,
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... |
Nocardia cerebral abscess: New concepts in diagnosis, management, and prognosis. | Three cases of multiple cerebral nocardial abscess are presented. All were cured by a combination of chemotherapy and surgery, a unique experience. Early detection, appropriate chemotherapy, absence of underlying immune malfunction, and surgically remediable disease are good prognostic indices in cerebral nocardiosis. ... | 501,368 | [
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0.2679954,
0.0102... |
Pineal apoplexy. | A case of haematoma in the pineal region is reported in a patient whose initial symptom was subarachnoid haemorrhage. The encapsulated haematoma and surrounding blood clots were removed surgically. Haemorrhage into a pineal cyst may have been the cause of this particular intracranial mass. | 501,370 | [
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Responses of vibrissa-sensitive cortical neurons in normal and prenatally X-irradiated rat. | 1. Rats were irradiated by 200 R of X ray on day 17 (the 18th day) of gestation through the body wall of the mother. When they underwent the following electrophysiological tests at the age of 3-4 mo, the somatosensory cortex showed a lack of layers II, III, IV, and Va, as described by previous investigators (3, 4). 2. ... | 501,397 | [
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0.092... |
Subclavian steal syndrome. Part 2: Intraoperative vertebral artery blood flow measurement. | Intraoperative vertebral artery blood flow was measured in two patients with symptomatic subclavian steal syndrome, before and after proximal end-to-side vertebral to common carotid artery transposition. This confirmed retrograde flow in the vertebral artery before transposition, and antegrade flow after transposition.... | 501,403 | [
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0.001018083,
0.13413... |
Carotid-cavernous fistula following percutaneous retrogasserian procedures. Report of two cases. | Carotid arterial puncture during percutaneous retrogasserian procedures is a common but usually harmless complication. Strokes, resulting presumably from carotid artery thrombosis, have been reported previously following percutaneous retrogasserian coagulation. The authors report two cases of carotid-cavernous fistula,... | 501,411 | [
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Posterior fossa xanthogranuloma. Case report. | A large subdural xanthogranuloma was removed from the posterior fossa of a 53-year-old woman with symptoms of Hand-Schüller-Christian disease. Two additional masses with similar density on computerized tomography were found in the hypothalamus and in the choroid plexus of the right lateral ventricle. | 501,416 | [
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0.070... |
Studies on the severity of various amino acid imbalances in the young male rat. | Relative severities of amino acid imbalance were compared in young male rats fed diets having an amino acid imbalance with respect to various essential amino acids. In the imbalanced diets, one or more essential amino acids were made to be low, ranging from suboptimal to two times the requirement, while the other essen... | 501,440 | [
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0.2823945,
0.1142... |
Orotic aciduria and increased nitrogen catabolism in rats. | In vitro incorporation of [14C] bicarbonate into orotic acid by rat liver slices was used to study the rate of orotic acid (OA) biosynthesis in the presence of physiological (0.73 mM) and saturation concentrations (5 mM) of NH4Cl. The influence of body size on OA synthesis in rats fed purified L-amino acid diets with (... | 501,442 | [
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... |
Effectiveness of dietary iron and ascorbic acid in the prevention and cure of moderately long-term lead toxicity in rats. | The protective and curative effects of high levels of dietary iron and ascorbic acid on moderately long-term toxicity in rats were examined. In rats fed a diet containing 500 ppm of lead for 56 days, growth retardation, reduction of food consumption, anemia, hypertrophy of the kidney and accumulation of lead in the bon... | 501,445 | [
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0.2... |
Bone mineral content in term and preterm appropriate-for-gestational-age infants. | Photon absorptiometry adapted for use in small infants was utilized to measure bone mineral content in 42 term and 30 perterm appropriate-for-gestational-age infants. BMC at birth correlated significantly with gestational age and birth weight. Sequential measurements of BMC in premature infants during the first three m... | 501,482 | [
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Postaxial acrofacial dysostosis syndrome. | Three patients with a postaxial acrofacial syndrome are presented; the features of these and three other previously described examples are set forth. The facies can be strikingly similar to that of the Treacher Collins syndrome. The limb deficiencies are postaxial, with absence or incomplete development of the fifth di... | 501,501 | [
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The effect of heparinized blood exchange transfusion on endotoxin induced disseminated intravascular coagulation (DIC). | Sepsis of the newborn induced by gram negative bacteria, especially E. coli is often accompanied by a severe coagulation disorder. It can be treated by blood exchange transfusion (ET) with heparinized blood. In this study the hematological effect obtained by the exchange transfusion was investigated in rabbits after in... | 501,509 | [
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Hydrodynamic characterization of a spin-filter dissolution device. | The spin-filter dissolution device was characterized using a two-dimensional convective diffusion model. Experimental model testing involved analysis of dissolution rates from nondisintegrating salicylic acid disks. The disks were prepared as double-layer tablets, with an ethylcellulose layer as a nondissolving surface... | 501,525 | [
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Bioavailability of chlorothiazide tablets in humans. | A urinary excretion bioavailability study was conducted in 12 healthy male subjects to evaluate three 250-mg and three 500-mg chlorothiazide tablet products. The study was a crossover design, and urine samples were collected 1, 2, 3, 4, 6, 8, 12, and 24 hr after administration of each dose. The resulting data were stat... | 501,528 | [
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Isolation of salicylsalicylic acid, acetylsalicylsalicylic acid, and acetylsalicylic anhydride from aspirin tablets by extraction and high-pressure liquid chromatography. | Aspirin and four salicylate impurities of aspirin (salicylic acid, acetylsalicylsalicylic acid, acetylsalicylic anhydride, and salicylsalicylic acid) were resolved by silica gell TLC and by high-pressure liquid chromatography (HPLC) on a reversed-phase C18 column. Care was necessary in the choice of a column because of... | 501,542 | [
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Effects of pyridoxine hydrochloride (vitamin B6) on chlorpromazine-induced serum prolactin rise in male rats. | To investigate if vitamin B6 inhibits prolactin release and to compare this effect to that of bromocriptine, a known suppressor of prolactin release, a study was conducted in male rats. Animals were pretreated with pyridoxine hydrochloride, pyridoxal hydrochloride, saline, or bromocriptine 30 min prior to receiving var... | 501,547 | [
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0.2733685,
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0.4067364,
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The effects of hypercapnia, hypoxia, exercise and anxiety on the pattern of breathing in man. | 1. The pattern of breathing, defined as the relations between tidal volume and inspiratory and expiratory times, was measured during the stimulation of breathing by carbon dioxide (hyperoxic rebreathing at rest) in twenty-seven healthy, young volunteers. 2. Most of the patterns (twenty) were divisible into two parts, f... | 501,598 | [
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[Pancreas pseudocyst examined by gastro-duodenal transit. From one observation (author's transl)]. | From one obstructive jaundice case examined, the Authors describe, radiologically, the result of a chronicle pancreatitis: pseudocyst with internal cysto-duodenal fistula and visualisation by radiographic examination; stenosis of second duodenum; aerobilia. | 501,705 | [
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Cost containment education efforts in United States medical schools. | Noting the increasing nationwide concern with factors relating to rising health care costs, the Association of American Medical Colleges surveyed 119 U.S. medical schools in the summer of 1978 to ascertain the degree of program activity in the area of cost containment education. A 100 percent response was achieved. An ... | 501,712 | [
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Student peer review of diagnostic tests at the Medical College of Ohio. | Students in their clinical clerkship performed retrospective reviews of their peers' laboratory usage patterns. Data covering the patient's history and physical examination, problem list, and treatment plan had been completed by students during internal medicine and pediatrics rotations. This information, along with th... | 501,715 | [
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Kinetic constants for intestinal transport of four monosaccharides determined under conditions of variable effective resistance of the unstirred water layer. | Theoretical considerations have suggested that variations in the resistance of the unstirred water layer (UWL) have a profound effect on the kinetic constants of intestinal transport. In this study, a previously validated in vitro technique was employed to determine the unidirectional flux rate of glucose, galactose, 3... | 501,734 | [
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Amino acids in a carbonaceous chondrite from Antarctica. | A carbonaceous chondrite from the Antarctic, referred to as the Allan Hills meteorite 77306, appears to be free from terrestrial organic contamination. The presence of both protein and non-protein amino acids and an equal abundance of D- and L-enantiomers of amino acids, is testimony to the extraterrestrial nature of t... | 501,741 | [
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The organic composition of the Allan Hills carbonaceous chondrite (77306) as determined by pyrolysis-gas chromatography-mass spectrometry and other methods. | The amino acid composition and the pyrolyzable organic content of the Antarctic Allan Hills meteorite (ALHA 77306.9 and ALHA 77306.17) was examined. The pyrolysis products are very similar to those of the Murchison meteorite. The identified amino acids are present at quite low levels, they are racemic and are structura... | 501,748 | [
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Child abuse: a black perspective utilizing a social-psychological model. | The majority of models utilized in the formulation of the dynamics of child abuse rely upon an individual psychopathological frame of reference. Not only is this approach limited, but it renders primary preventive approaches virtually impossible. The author presents a social-psychological model, with the recommendation... | 501,758 | [
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0.0146242,
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Studies on the toxicity of coal-tar dyes. I. Photodecomposed products of four xanthene dyes and their acute toxicity to fish. | The acute toxicity of photodecomposed products of Erythrosine, Eosine, Phloxine and Rose Bengale were studied, since it was found that toxicity of these dyes to fish increased after the dyes had been photoirradiated. Photodecomposed products of the dyes were isolated and identified with UV, IR, NMR spectra and the acut... | 501,760 | [
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-... |
Broken paediatric appointments at the University of Benin Teaching Hospital, Benin City. | Appointment system was introduced to the University of Benin Teaching Hospital at the initial stage of the Hospital development. This is a new experience to the local community which is largely illiterate. The appointment breaking was low contrary to expectation. Indifference or negligence accounted for a high percenta... | 501,764 | [
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Thyroid carcinoma presenting as a tracheal tumor. Case report and literature review with reflections on pathogenesis. | Ectopic thyroid tissue within the submucosa of the trachea is a rare cause of upper airway obstruction. Most case reports in the literature record examples of intratracheal goiter with only occasional reports of neoplasms arising from such thyroid rests. This report describes a young female patient with a malignant tum... | 501,775 | [
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0.3460406,
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Spleen focus-forming Friend virus: identification of genomic RNA and its relationship to helper virus RNA. | The genome of the defective, murine spleen focus-forming Friend virus (SFFV) was identified as a 50S RNA complex consisting of 32S RNA monomers. Electrophoretic mobility and the molecular weights of unique RNase T1-resistant oligonucleotides (T1-oligonucleotides) indicated that the 32S RNA had a complexity of about 7.4... | 501,795 | [
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0... |
Structural role of the polyglutamate portion of the folate found in T4D bacteriophage baseplate. | Three types of reagents were used to determine the structural role and location of the polyglutamate portion of the Escherichia coli T4D bacteriophage baseplate dihydropteroyl hexaglutamate. These reagents were examined for their effect in vitro on some of the final steps in phage baseplate morphogenesis. The reagents ... | 501,801 | [
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[Laboratory and clinical studies of cefamandole in children (author's transl)]. | Laboratory and clinical studies of cefamandole (CMD), a new semisynthetic cephalosporin, were investigated and following results were obtained. 1) Absorption and excretion study following 25 mg/kg intravenous administration was carried out in pediatric patients. In 6 cases, mean serum levels of 116.7 +/- 24.0 microgram... | 501,921 | [
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0.1256605,
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Cross-sectional echocardiographic findings of left ventricular thrombi in a ten-year-old patient with cardiomyopathy. | Using cross-sectional echocardiography, left ventricular thrombi were easily found in a 10-year-old boy suffering from congestive heart failure resulting from long-standing endocardial fibroelastosis. Ten days after this procedure, the patient suddenly manifested the signs of acute embolic occlusion of the abdominal ao... | 501,933 | [
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... |
Distribution of colloidal carbon in lymph nodes of mice injected by different routes. | Systemic distribution of colloidal carbon injected by different routes was examined microscopically at 24 hr postinjection, After intravenous injection, carbon was mildly distributed in postcapillary venules of systemic lymph nodes, in addition to heavy deposition in the liver, spleen and bone marrow. Carbon was deposi... | 502,078 | [
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Influence of magnesium on the beta-inhibition of catecholamines in the uterine circular muscle of estrogen-treated rats. | The effects of Mg and isoprenaline on the uterine circular muscle of ovariectomized rats which were injected with estradiol for 2--6 days were investigated. The muscle strip exhibited an action potential that was composed of a spike and a plateau, and also exhibited a twitch-like contraction due to electrical stimulati... | 502,091 | [
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0.1260763,
0.1933773,... |
[Flow sheets of urine samples in haemolytic uraemic syndrome. Examinations by analytic isotachophoresis (author's transl)]. | In 29 urinary fractions of six children with haemolytic uraemic syndrome (HUS) a specific substance could be demonstrate during the acute phase of the disease by means of isotachophoresis. Urine tests in six patients with other kidney diseases and with uraemia and in seven healthy persons did not show this substance. F... | 502,353 | [
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0.7733424,
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... |
[Demonstration of acetylcholine receptor antibodies in the serum of myasthenia gravis patients applying affinity chromatographically purified human acetylcholine receptor preparations (author's transl)]. | Sera from 75 patients with Myasthenia gravis were tested for acetylcholine receptor antibodies using acetylcholine receptors from human skeletal muscle. From the crude Triton x-100 extract, which has so far been used for antibody tracing, a pure acetylcholine receptor preparation was obtained by affinity chromatography... | 502,355 | [
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[Effect of small gravitational loads on human water-salt metabolism and kidney function during prolonged immersion]. | It was demonstrated that renal excretion of fluid, osmotically active substances and electrolytes could be reduced, using low gravitational exposures (+GZ). The degree and duration of water and electrolyte retention were different with respect to the experimental time. The major physiological mechanisms of the changes ... | 502,423 | [
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... |
[Effect of strong, infralow-frequency magnetic fields on bone marrow cell division]. | The effect of an infralow frequency magnetic field of 3-127 kOe applied for 1 hr on mitotic activity, frequency of chromosomal aberrations and number of bone marrow cells of mice was studed. The exposure of mice to fields of 3 and 8 kOe stimulated and to fields of 54 and 127 kOe inhibited mitotic activity. No increase ... | 502,429 | [
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0.0287... |
In vivo detection of rabbit atropinesterase. | The comparability of an in vivo rapid screening test for the presence of atropinesterase with an in vitro standard colorimetric test was assessed using 410 male and female New Zealand white rabbits. The results from both tests were in agreement in 405 of the 410 (98.8%) rabbits compared. One false negative and four fal... | 502,459 | [
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Regurgitation and choke in rats. | Male and female F344 rats choked on fecal pellets and regurgitant during the course of two long-term experiments. Each study involved feeding standard and high bulk diets containing 10% wood cellulose or 10% chrysotile asbestos fiber. Choke deaths occurred at all stages of the experiments. A total of 36 of 774 (4.6%) r... | 502,462 | [
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0.06501744... |
The effects of triamcinolone acetonide on the voice. | With the exception of the pioneering work by Damsté in the mid 1960s and early '70's, no long term quantitative research on voice changes subsequent to drug therapy has been reported. This study reports the effects of a specific cortico-steroid, triamcinolone acetonide, on selected aerodynamic and acoustic parameters r... | 502,506 | [
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... |
Extramastoid cholesteatoma in chronic ear disease: a report of two cases. | Two patients who had undergone radical mastoid surgery developed an isolated focus of cholesteatoma embedded in the sternomastoid muscle just below the mastoid tip. In one instance the etiology was felt to be iatrogenic implantation of squamous epithelium. In the second, unrecognized extension from the mastoid tip prob... | 502,696 | [
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... |
Toward the total rehabilitation of the alaryngeal patient. | Rehabilitative efforts directed toward the total laryngectomee are receiving increasing interest. Fifteen to 50% of laryngectomees fail to develop speech, and 50% do not return to full employment. Many make poor psychological adjustment. A study was designed wherein laryngectomees and their families were individually i... | 502,702 | [
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... |
Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid. | 2-Tetradecylglycidic acid (TDGA), a hypoglycemic agent, has been found to be a very effective inhibitor of de novo fatty acid synthesis by isolated hepatocytes. A comparison was made between the effectiveness of TDGA and 5-(tetradecyloxy)-2-furoic acid (TOFA), a hypolipidemic agent, on the metabolic processes of isolat... | 502,765 | [
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[Respiratory tract in workers chronically exposed to cement dust]. | 175 men working at productive divisions of a cement plant (average age 39,5 years +/- 8.3, average duration of employment 9.3 years +/- 4.8) and 50 controls (average age 38.7 +/- 11.9 and average duration of employment 10.7 +/- 10.0) were examined. The survey involved: a complex evaluation of respiratory tract, includi... | 502,840 | [
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Is the menopausal age rapidly changing? | A population study of women in Goteborg, Sweden was carried out in 1968--1969. Altogether 1462 women participated (participation rate 90.1%). Five age strata were studied: 38, 46, 50, 54 and 60 (women born in 1930, 1922, 1918, 1914 and 1908, respectively). The same women were re-studied in 1974--1975. Information about... | 502,872 | [
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Menopausal effects on risk factors for ischaemic heart disease. | Women of almost identical age but with a different menopausal state were compared in a population study of women, which was carried out in Goteborg, Sweden. The group of women aged 50 comprised about the same number of still menstruating and postmenopausal women and was, therefore, especially suitable for such a compar... | 502,873 | [
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Isolation of influenza A virus from budgerigars and its serological characterization. | A hemagglutinating agent was isolated from the respiratory organs of budgerigars suffering from diarrhea and malnutrition. This agent, possessing neuraminidase activity, was identified as influenza A virus by the double immunodiffusion test. The results of hemagglutination and neuraminidase-inhibition tests with monosp... | 502,902 | [
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[Kinetics of Candida lipolytica yeast growth and biosynthesis of alpha-keto acids with thiamine deficiency in media with different carbon sources]. | The growth kinetics of Candida lipolytica on glucose, acetate and hexadecane was studied in batch cultures at thiamine deficiency. The growth at the deceleration phase is of a linear character. The transition from the exponential phase to the linear one is accompanied with the accumulation of alpha-keto acids in the cu... | 502,909 | [
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... |
Optimizing pacing lead design: redesign of the tined lead. | Technical data derived from experimental and clinical experience in the field of lead/catheter implants formed the basis for developing a set of technical design criteria for pacing leads. Four related levels of technical data were identified: Basic lead components, mode of installation, application site, and mode of u... | 502,927 | [
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0.1943707,
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Repair of UV-endonuclease-susceptible sites in the 7 complementation groups of xeroderma pigmentosum A through G. | 7 strains of human primary fibroblasts were chosen from the complementation groups A through G of xeroderma pigmentosum; these strains are UV-sensitive and deficient in excision repair of UV damage on the criterion of unscheduled DNA synthesis (UDS). They were compared with normal human fibroblasts and one xeroderma pi... | 503,100 | [
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Enhancement of excision-repair efficiency by conditioned medium from density-inhibited cultures in V79 Chinese hamster cells: evidence for excision repair as an error-free repair process. | Conditioned medium from density-inhibited V79 Chinese hamster cell cultures, given as a post-treatment to UV-irradiated homologous cells, was demonstrated to reduce the lethal action of ultraviolet light by temporarily blocking DNA replication. Since the increased survival was not affected by various non-toxic concentr... | 503,101 | [
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0.05362278,
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Antigenic modulation and receptor loss in experimental autoimmune myasthenia gravis. | Immunization of groups of rats with 0.1- 100 microgram of acetylcholine receptor (AChR) purified from the electric organ of Torpedo californica resulted in dose-dependent (1) loss of acetylcholine receptor from the rats' muscles, (2) binding of antibodies to many of the receptors remaining in muscle and (3) production ... | 503,104 | [
0.2550744,
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-0.1828572,
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-0.1651209,
-0.1251272,
0.195719,
-0.1072656,
0.04111027,
0.1714624,
0.1241479,
-0.00859265,
-0.08135379,
-0.1846998,
0.02842315,
-0.920158,
-0.1914919,
0.09672768,
0.003297826,
0.2208236,
0.3507451,
-0.1330409,
... |
Freeze-fracture study of muscle plasmalemma in normal and dystrophic chickens. | We compared the freeze-fracture morphology of the plasmalemma of the pectoralis major muscle taken from normal and dystrophic chickens at adult, embryonic, and early posthatching stages. Developmental changes were more conspicuous in surface caveolae than in intramembranous particles. The most striking differences betw... | 503,105 | [
-0.2348332,
0.1302068,
-0.261518,
-0.5133557,
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0.1925549,
0.4031519,
0.03517257,
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0.0392928,
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-0.1999397,
0.2231433,
-0.197431,
0.6231572,
0.4633384,
-0.04313832,
... |
Coitus and associated amniotic-fluid infections. | Data were analyzed from 26,886 pregnancies to determine whether coitus is involved in the genesis of amniotic-fluid infections. The frequency of infection was 156 per thousand births when mothers reported coitus once or more per week during the month before delivery, versus 117 per thousand when no coitus was reported ... | 503,112 | [
0.0892573,
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0.004887238,
0.2124413,
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0.156222,
0.3272842,
0.04741098,
-0.08008767,
0.3738775,
-0.1597721,
-0.1057851,
... |
Muscle breakdown and repair in polymyositis: a case study. | Muscle breakdown and repair were measured by metabolic balance techniques in a patient with polymyositis who was being treated with prednisolone and azathioprine. Changes in body muscle mass that had been estimated from nitrogen and phosphorus balances correlated with antropometric assessments of thigh muscle mass and ... | 503,107 | [
-0.1560431,
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0.09960616,
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0.4564824,
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0.08155228,
-0.2031213,
-0.05868556,
-0.1353071,
0.4517578,
0.1309072,
-0.1700504,
0.209680... |
Increased insulin sensitivity and insulin binding to monocytes after physical training. | We studied the effect of physical training on in vivo tissue sensitivity to insulin and insulin binding to monocytes in six previously untrained healthy adults. Physical training (one hour of cycle-ergometer exercise four times per week for six weeks) failed to alter body weight but resulted in a 20 per cent increase (... | 503,113 | [
-0.02968375,
0.06811395,
-0.4842082,
0.06967679,
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0.1968821,
0.1315695,
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0.05915176,
-0.1913264,
0.2571824,
-0.2168692,
-0.1173944,
-0.2340036... |
Should operations be regionalized? The empirical relation between surgical volume and mortality. | This study examines mortality rates for 12 surgical procedures of varying complexity in 1498 hospitals to determine whether there is a relation between a hospital's surgical volume and its surgical mortality. The mortality of open-heart surgery, vascular surgery, transurethral resection of the prostate, and coronary by... | 503,167 | [
0.02546551,
0.004659631,
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0.105394,
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0.1134531,
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0.2615086,
0.2621405,
0.03313963,
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0.08783667,
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0.2131038,
0.05678499,
-0.204845,
0.434752,
0.3081722,
-0.1170743,
... |
[D-Penacillamine. From constituent of penicillins to significant drug]. | D-Penicillamine is used against a variety of diseases. For many years it has been successful in treating Wilson's disease, cystinuria and heavy-metal poisonings. It also proved to be effective against rheumatoid arthritis, scleroderma, chronic active hepatitis, pulmonary fibrosis and multiple sclerosis. However, the us... | 503,243 | [
-0.1383866,
-0.3880942,
-0.3093346,
0.2303559,
0.05901838,
-0.002670095,
-0.1492635,
0.2506675,
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0.3118024,
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0.1240484,
0.2291187,
0.2400876,
0.01559919,
-0.0746796,
0.070632,
0.2659932,
-0.18251,
0.2018514,
0.2186034,
0.3326749,
0.01487789,
-0.09... |
In vivo release of endogenous GABA in the cat hypothalamus. | The posterior hypothalamus of anaesthetized cats was superfused with artificial cerebrospinal fluid through a push-pull cannula and the release of endogenous GABA from the hypothalamus into the superfusate was studied. The resting release of GABA varied rhythmically, since phases of high rate of release were separated ... | 503,246 | [
-0.01957159,
-0.163192,
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0.05408528,
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0.2329277,
0.1290496,
-0.112336,
0.05438604,
0.1172788,
-0.2314063,
-0.02715935,
-0.3299006,
0.2092635,
0.2941223,
-0.159309,
0.1024907,
-0.119039,
0.06045914,
0... |
Aseptic peritonitis in patients on maintenance peritoneal dialysis. | An 'epidemic' of aseptic peritonitis occurred in our peritoneal dialysis unit, affecting 5 of 20 patients. Acute and convalescent viral titers were normal in all 5. The peritoneal fluid of the affected patients was not tested for endotoxin, but endotoxin was found in subsequent dialysis fluids from two machines in the ... | 503,270 | [
-0.0220318,
0.04495516,
-0.1979198,
0.003408602,
0.0007438358,
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0.2620736,
-0.06277215,
0.005824049,
0.4274838,
-0.01109306,
-0.2010591,
-0.1103744,
-0.002766788,
0.1029659,
0.009884711,
-0.01037258,
-0.05419858,
... |
[Malignant ano-rectal melanoma]. | Malignant melanoma of the anus, anorectal junction and ampulla respectively was observed in 3 patients treated at the Busto Arsizio Hospital's General Surgery Division in the period 1967 to 1978. An account is given of the anatomopathological picture, symptoms, treatment, and prognosis of these forms. | 503,341 | [
0.007798581,
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-0.2789783,
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0.04889499,
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-0.294048,
-0.1054892,
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0.3202555,
0.02196087,
0.05713025,
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-0.1601603,
0.05534642,
0.4071358,
-0.008532532,
0.4908322,
0.07718798,
-0.03809... |
[Reye's syndrome. Discussion of a clinical case]. | A case of Reye's syndrome in an unweaned child aged 5 1/2 months is reported. The boy presented ingravescent neurological symptomatology accompanied by sporadic gastrointestinal signs and by marked renal impairment, with total, or nearly total absence of pathognomonic laboratory data. The diagnosis was confirmed by aut... | 503,352 | [
-0.3210132,
-0.1817899,
0.004589811,
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0.1670974,
0.1813863,
0.3489923,
-0.03565858,
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-0.3571371,
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-0.5210574,
0.3556371,
0.002407453,
0.1773607,
0.3334699,
0.1125245,
0.07614122,
... |
[Maternal and neonatal factors determining bilirubinemia during the 1st four days of life]. | The influence of various maternal and neonatal factors on blood bilirubin is examined. An increase in neonatal values may be due to the relatively advanced age of the mother, whereas neonatal age, sex and weight, increase in maternal weight during pregnancy, and maternal body surface area would appear to be without inf... | 503,353 | [
0.1044964,
-0.1338211,
-0.2481957,
-0.07446701,
0.2619818,
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0.01889157,
0.120256,
0.07300955,
-0.03365385,
0.1035239,
-0.006879051,
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-0.2676104,
-0.3865163,
0.4375529,
0.04458326,
0.2143275,
0.2849765,
0.1903807,
-0.2033859,
... |
[Distribution and incidence of malignant tumors in various valleys of the Biella district]. | Statistical assessment is made of the cases of malignant recorded in the Piedmont Tumour Register for the nine Biella districts in the period 1965-1971. Differences in the distribution of tumours were noted. Taken overall, however, the results in the Biella district, the province of Vercelli, and the rest of Piedmont w... | 503,361 | [
-0.1094003,
-0.2171157,
0.02972188,
-0.03990883,
-0.06888477,
-0.3397612,
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0.2290391,
0.1584934,
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0.07709187,
0.0716061,
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-0.03027637,
0.2727998,
0.4483179,
0.2109123,
0.5841957,
0.3917831,
0.03654216,
... |
Comparison of prostaglandin E2 and intravenous oxytocin for induction of labor. | One hundred nulliparas at term were randomly given oxytocin intravenously or prostaglandin E2 (PGE2) gel (0.5 mg PGE2) intracervically in order to study the effect on cervical ripening and the frequency of successful inductions. In the presence of a favorable cervix both methods seemed equally efficacious in inducing l... | 503,385 | [
0.1143964,
0.2650402,
-0.2217242,
0.1343781,
0.1866642,
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-0.09341203,
0.2841196,
0.06746472,
-0.04979413,
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-0.04972532,
-0.2009921,
-0.21042,
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-0.4475902,
0.08084534,
-0.009586928,
-0.2330141,
0.3095627,
0.412728,
0.03581727,
... |
Body temperature recordings during oral prostaglandin E2 induction of labor. | Body temperature measurements have been recorded in 99 patients during the course of labor induction with oral prostaglandin E2 (PGE2). From the data obtained, there is no evidence that oral PGE2, in the usual dosage for induction of labor, acts as a pyretic agent. If fever is encountered during the course of an oral P... | 503,386 | [
-0.07276973,
0.09085431,
-0.3031613,
-0.05210777,
-0.06287593,
-0.0360695,
-0.2340889,
-0.3372134,
0.2302261,
-0.2888627,
0.1576356,
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0.1528346,
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-0.4351692,
-0.04436916,
-0.02964187,
0.182128,
0.1956155,
0.20432,
-0.1534602,
... |
Fetal heart rate tracing during sickle cell crisis: a cause for transient late decelerations. | A case of maternal sickle cell anemia crisis is presented. A continuous fetal heart rate (FHR) tracing demonstrates late decelerations that reversed when the mother's condition improved. The importance of recognizing this reversible late deceleration problem is discussed in terms of increasing fetal maturity. | 503,396 | [
-0.2781386,
-0.250502,
-0.4298272,
-0.2560029,
0.3389279,
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0.06332528,
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0.03627903,
0.1539541,
0.4473168,
-0.2902169,
0.09095271,
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-0.2176635,
-0.1358061,
0.124803,
-0.1839278,
0.1097034,
-0.05116656,
-0.1461401,
... |
Cholestatic jaundice of pregnancy: new perspectives. | Cholestatic jaundice of pregnancy is a condition characterized by pruritus, icterus, or both during pregnancy. A total of 9 pregnancies complicated by cholestatic jaundice are presented. Three of these cases are presented in detail because they reflect complications that can occur with this condition. The literature o... | 503,397 | [
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0.02393494,
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0.2106754,
0.01735276,
0.1204631,
0.07558704,
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0.1667602,
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-0.3658284,
0.3790144,
0.06039444,
-0.3248689,
-0.04166127,
0.348599,
-0.07568345... |
Recurrent endodermal sinus tumor during pregnancy. | A case is reported of a patient who was found to have an endodermal sinus tumor coincident with pregnancy. She maintained a complete clinical response for 12 months after conservative surgery, uterine aspiration, and multiple-agent chemotherapy. Tumor recurrence appeared with a second pregnancy. A healthy infant was de... | 503,398 | [
-0.0558634,
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0.2284055,
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0.3487948,
0.02776604,
0.2082748,
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0.1659188,
0.0990019,
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-0.05979295,
-0.1632917,
-0.1332071,
0.1738994,
-0.01394774,
-0.06165533,
0... |
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