title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Survival with total occlusion of the left main coronary artery. Significance of the collateral circulation. | Four patients with total occlusion of the left main coronary artery are described. Angina pectoris was severe (NYHA class 3--4) and had lasted 20 months to seven years. Three patients had experienced a myocardial infarction. All displayed large collaterals arising from a nearly normal right coronary artery and feeding ... | 498,263 | [
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Characterization of Op3, a lysis-defective mutant of bacteriophage f2. | We have isolated a conditional lethal mutant of bacteriophage 12 which makes plaques only on E. coli strains carrying a UGA suppressor. It grows normally in nonsuppressing hosts but does not lyse such strains. The mutation complements with amber mutations in each of the three known phage cistrons. These observations le... | 498,270 | [
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Metallothionein degradation: metal composition as a controlling factor. | Degradation of the cadmium (Cd)-induced protein, metallothionein (MT) was studied in rat liver and kidney. The half-times (t1/2s) for degradation of the protein were found to vary according to the concentration of Cd in the tissues. In animals containing high Cd2+ concentrations, the t1/2 of degradation was significant... | 498,367 | [
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Epidemiology of cutaneous leishmaniasis in Afghanistan. Part I: Zoonotic cutaneous leishmaniasis. | From June to September 1977, a preliminary epidemiological investigation was carried out in some parts of northern Afghanistan (Aqcha, Mazar-e-Sharif and Paul-e-Khombri). The disease in these areas is of zoonotic type having Rhombomys opimus as reservoir and P. caucasicus and P. papatasi as vectors. | 498,385 | [
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[3 cases of tetradontidae poisoning observed in France]. | The authors report 3 cases of food poisoning, one of them leading to a swift death, which they were able to observe on 1st January 1978 in the Drôme (France). They explain how burbot was the suspected food responsible for the auto-intoxication and how the X ray examination of the vertebrae of this fish allowed them to ... | 498,391 | [
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Characteristics of "old timer" hockey play. | Many Canadian adults play Old Timer hockey to improve and/or maintain their cardiorespiratory fitness. This review examined the intensity and duration of play that characterizes adult noncontact hockey. The exercise intensity was assessed by continuously monitoring the heart rate response via telemetry. The duration of... | 498,399 | [
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Determination of daunorubicin, doxorubicin and their fluorescent metabolites by high-pressure liquid chromatography: plasma levels in DBA2 mice. | A rapid and nondestructive analytic method has been developed to separate and quantitate daunorubicin, doxorubicin, and their metabolites in biological fluids. This method combines the efficiency of high-pressure liquid chromatography and the sensitivity of fluorescence monitoring. The drug plasma levels achieved after... | 498,412 | [
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Uptake of free and DNA-bound daunorubicin and doxorubicin into human leukemic cells. | Leukemic cells from seven patients with acute nonlymphoblastic leukemia and granulocytes, and mononuclear cells from three healthy controls were isolated by centrifugation on metrozoate-dextran. The intracellular accumulation of both the free and DNA-bound forms of daunorubicin and doxorubicin was studied in vitro. The... | 498,420 | [
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Child health problems and programmes in two underdeveloped areas of the USA. | There are areas in the USA where the health problems of children a similar to those of children in some developing countries. Traditional US health programmes have contributed to an improvement in the health status of many of these children but there remains much more to be done. | 498,425 | [
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Comparative value of eight M-mode echocardiographic formulas for determining left ventricular stroke volume. A correlative study with thermodilution and left ventricular single-plane cineangiography. | Sixty-six consecutive patients without left ventricular volume overload, significant arrhythmia or significant pericardial effusion were examined by M-mode echocardiography immediately before diagnostic left- and right-heart catheterization. Using various echocardiographic measurements, left ventricular stroke volume (... | 498,456 | [
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Significance of block distal to the His bundle induced by atrial pacing in patients with chronic bifascicular block. | Twenty-one of 496 (4%) patients with chronic bifascicular block, studied and followed prospectively, had block distal to the His bundle (BDH) induced by atrial pacing during initial electrophysiologic studies. In six, BDH was noted during pacing-induced atrioventricular (AV) nodal Wenckebach periods (at paced rates of ... | 498,473 | [
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Response-surface co-optimization of reaction conditions in clinical chemical methods. | We describe the theory and applications of the response-surface approach to simultaneous optimization (co-optimization of multiple interdependent variables. The co-optimization experiments are designed according to a selected response-surface model. Computer-assisted analysis includes fitting the data to the model, tes... | 498,506 | [
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Comparison between immunofixation and crossed immunoelectrophoresis for the detection of C3 activation products. | C3 breakdown products were measured in 51 fresh and stored sera and/or EDTA plasma samples from 18 healthy subjects, 8 patients affected by essential mixed cryoglobulinaemia, and 15 patients with miscellaneous glomerulonephritis, by simultaneous crossed immunoelectrophoresis and immunofixation. C3 splitting products, a... | 498,518 | [
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A semi-automated method for the determination of glycosylated haemoglobin. | A new routine, automated method for the determination of glycosylated haemoglobin is presented. The method offers improvements in analytical capacity, and precision, together with reduced running costs over existing methods, which should assist in making the determination of glycosylated haemoglobin more readily availa... | 498,531 | [
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The interaction of cigarette smoking and chronic drug ingestion on human drug metabolism. | 1. Drug metabolism was assessed by the disappearance rate of antipyrine as measured in saliva. Results were expressed in terms of both clearance and half life. 2. Basal measurements of antipyrine disappearance rate were performed in seven non-smokers and six smokers. After administration of glutethimide 250 mg daily fo... | 498,592 | [
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Fatigue fracture ossa pubes due to obesity. Report of a case. | A 60-year-old menopausal woman, who was in otherwise good health, save for morbid obesity, developed fatigue fractures of her ossa pubes, bilaterally, superiority and inferiorly. This type of pathologic fracture seems not to have been reported previously. | 498,634 | [
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Debrisoquin hydroxylation polymorphism among Ghanaians and Caucasians. | The alicyclic and aromatic hydroxylation of debrisoquin was studied in Ghanaians. As in a previously studied Caucasian population, the alicyclic 4-hydroxylation of debrisoquin in Ghanaians was polymorphic. Three phenotypes were observed: homozygous extensive metabolizers (58%), heterozygous extensive metabolizers (36%)... | 498,701 | [
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Multiple-dose amikacin kinetics in pediatric oncology patients. | Amikacin kinetics was studied in 8 pediatric oncology patients who received the drug by intravenous infusion over 30 or 60 min at a dose of 5 mg/kg every 6 or 8 hr. This regimen is recommended but, due to patient variability, patients should be monitored. Dosing intervals during 1 or 2 and 3 or 4 days of therapy were s... | 498,705 | [
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Oral melphalan kinetics. | The systemic availability of melphalan after oral administration is not well known. Most patients are put on a fixed oral dosage regimen. We have studied the disposition of melphalan in 14 patients after single oral doses. Five were also studied after receiving the same dose intravenously. Oral melphalan had a mean pla... | 498,715 | [
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Screening methods using sulfamethazine for determining acetylator phenotype. | Analysis of sulfamethazine (SMZ) kinetics in man has revealed complexities including wide intersubject variability. In our study, an attempt was made to assess the potential influence of changes in nonmetabolic parameters (absorption and urinary elimination rate constants) on the markers of acetylation capacity normall... | 498,718 | [
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Delta-9-tetrahydrocannabinol levels in street samples of marijuana and hashish: correlation to user reactions. | In a 6-year period, 435 alleged cannabis samples were accessioned by an urban street drug analysis program, and clinical histories were correlated with laboratory results. The most common reason for submission of a sample was suspicion of adulteration; however, such samples were usually unadulterated but had high poten... | 498,736 | [
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Photoallergic contact dermatitis to men's perfumes. | Three patients with photosensitive eruptions related to the use of different men's perfumes were evaluated. We found that they were photoallergic to musk ambrette, an inexpensive, readily available synthetic perfume ingredient. Studies of cross-reactivity with other perfumed colognes and after-shave lotions suggest tha... | 498,771 | [
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Elementary systems of medicine. | The beliefs about causes of disease, orientations to medical problems, and the treatment practices of relatively small and elementary societies are reviewed and analyzed. Selected published reports of this problem area of ethnomedicine serve as source material. An attempt is made to induce generalizations which will se... | 498,807 | [
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Use of metrizamide in coronary arteriography. | In the investigation of the arteriae coronariae by means of angiography, a comparative study has been done of two contrast media in the same patients, by injecting these media in a randomized order. The contrast media are sodium methylglucamine diatrizoate (10:66) and metrizamide, both used in a concentration of 370 mg... | 498,916 | [
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A comparison of Isopaque Coronar 370 and Amipaque in angiocardiography in infants. | Experimental studies and some clinical investigations have indicated that Amipaque (metrizamide) is less cardiotoxic than other contrast media in common use for angiocardiography. It, therefore, seemed motivated to find out whether these findings are valid in the high-risk group of neonates and small infants subjected ... | 498,917 | [
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Thrombosis after phlebography? | In contrast to the report by Albrechtsson, we have never seen clinically manifest thrombosis in more than 20,000 phlebographies; only small, clinically insignificant thrombi in a very few cases. The reason is because we have used only 40 cm3 of a 45% contrast medium in connection with heparin precaution. However, there... | 498,921 | [
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[Irrigation of the internal organs and the effect of the protein hydrolysate, Hydroport, in deep burns in rats]. | The authors caused buring of III to IV degree, 10--15% in rats of the Wistar strain. The animals were divided into 4 groups: 1) healthy; 2) burned-nontreated; 3) burned-treated with saline; and 4) burned-treated with hydrolysate. Saline and hydrolysate were administered immediately after thermic trauma, and vasculariza... | 499,044 | [
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Prolonged stimulation of adenylate cyclase activity and testosterone production by cholera enterotoxin with suppression of gonadotropin release in rats. | Endocrine effects of cholera enterotoxin (CET) on male gonads were investigated in normal and hypophysectomized rats. After intratesticular injection of 5 micrograms of CET in the bilateral testes of normal rats, serum testosterone concentration remarkably increased after 24 hr, remained significantly elevated for at l... | 499,086 | [
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0.03853777,
0.2811454,
-0.1242064,... |
Effect of dexamethasone on plasma concentrations of LH, FSH and testosterone in women with hirsutism. | Thirty sexually mature women with hirsutism were treated with 3 x 1.5 mg dexamethasone per day over a period of three days. Before and after treatment, plasma concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone were determined. While an effect of dexamethasone on LH plasma l... | 499,098 | [
-0.005195376,
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0.1303113,
0.3489349,
0.2081487,
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... |
Pilocarpine and atropine effects on the mitotic activity of the adrenal cortex. | Because of the postulated presence of direct nervous cholinergic connections between the adrenal cortex and the hypothalamic centers, effects of pilocarpine and atropine on the adrenal cortex mitotic activity were examined. The obtained results show that pilocarpine stimulates and atropine inhibits the proliferation of... | 499,099 | [
0.0908405,
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0.1615265,
0.05401882,
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0.3801752,
-0.03433428,
-0.0329351... |
Inhibition of thyroid monoamineoxidase by thyroxine and some specific inhibitors. | Rat thyroid monoamine oxidase (MAO) was inhibited by the non-hydrazine derivatives paragyline and tranylcypromine to a higher degree than the hydrazine derivative iproniazide. MAO was also inhibited by monoiodotyrosine and thyroxine. These results indicate that MAO may be an important enzyme in the metabolism of biogen... | 499,103 | [
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0.002352598,
-0.040... |
Antipyretic effect and plasma concentrations of rectal acetaminophen and diazepam in children. | Plasma levels of acetaminophen (paracetamol) and diazepam were measured in 9 children by gas chromatography after administering these drugs simultaneously in separate suppositories. The antipyretic effects of oral and rectal acetaminophen-diazepam combinations were also studied and compared with that of oral or rectal ... | 499,113 | [
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0.342131,
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Measuring the public health impact of the aneuploidies. | If the protection of man against mutagenic agents in general, and against those that cause aneuploidies in particular, is to have an increasingly rational basis with the passage of time, quantitative or at least semiquantitative assessments of risks are needed. These should take into account both the likely numbers of ... | 499,125 | [
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0.2757338,
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Activities of hepatic enzymes related to ethanol oxidation and effects of ethanol on hepatic metabolites in rats with chronic liver injury. | To study the effects of ethanol on liver chronically injured by CCl4, activities of hepatic enzymes related to ethanol oxidation, influences of ethanol on hepatic metabolites, and blood ethanol disappearance were observed. (1) Activities of alcohol dehydrogenase, low- and high-Km aldehyde dehydrogenase, microsomal etha... | 499,175 | [
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0.01332209,
... |
Long-term effect of glucagon administration on rat liver L-type pyruvate kinase. | After 5 h of treatment with glucagon, liver L-type pyruvate kinase (ATP: pyruvate 2-0-phosphotransferase; EC 2.7.1.40) showed a significant decrease of K0.5 and the Hill coefficient (nH) in the absence of fructose 1,6-diphosphate. However, in the presence of fructose 1,6-diphosphate, liver enzymes from treated rats sho... | 499,179 | [
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0.09127532,
0.1640295,
0.0698518,
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0... |
Mechanical power and segmental contribution to force impulses in long jump take-off. | Changes in total mechanical work, its partitioning into different energy states, mechanical power, force-time characteristics, force impulses of body segments and mass center's pathway characteristics during long jump take-off were investigated on four national and six ordinary level athletes. Both cinematographic and ... | 499,190 | [
-0.2783158,
0.2684477,
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0.1084536,
0.07077442,
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0.2697102,
0.3130709,
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The significance of the aerobic-anaerobic transition for the determination of work load intensities during endurance training. | Anaerobic and aerobic-anaerobic threshold (4 mmol/l lactate), as well as maximal capacity, were determined in seven cross country skiers of national level. All of them ran in a treadmill exercise for at least 30 min at constant heart rates as well as at constant running speed, both as previously determined for the aero... | 499,194 | [
-0.304386,
0.2210315,
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0.04908955,
0.07818022,
0.01126041,
0.2580176,
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EMG frequency spectrum, muscle structure, and fatigue during dynamic contractions in man. | Fatigue of the vastus lateralis muscle was studied in healthy well-conditioned students, who differed considerable regarding their muscle fibre type distribution. Muscle force decline during repeated maximum voluntary knee extensions at a constant angular velocity (180 degree X s-1 or rad X s-1), using isokinetic equip... | 499,196 | [
0.08768015,
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0.3168494,
0.01517649,
0.1796803,
... |
Oxygen dissociation curves in trained and untrained subjects. | Oxygen dissociation curves (ODC) in whole blood and organic phosphate concentrations in red cells were determined in 10 highly trained male athletes (TR), 6 semitrained subjects (ST) who played sports regularly at low intensities and 8 untrained people (UT). In all groups standard ODCs (37 degrees C, pH 7.40, PCO2 appr... | 499,197 | [
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... |
Role of the mitochondrial anion transporters in the regulation of ammoniagenesis in renal cortex mitochondria of the rabbit and rat. | The purpose of this study was to investigate factors which may regulate ammoniagenesis in the kidney cortex. Emphasis was placed on the segment of the pathway by which the carbons derived from glutamine must exit from the mitochondrion. These pathways were compared in the rat with high rates of ammoniagenesis and the r... | 499,211 | [
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0.215382,
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Metabolism of isolated kidney tubules. Interactions between lactate, glutamine and oleate metabolism. | Kidney-cortex tubule suspensions were prepared by collagenase treatment of kidney cortex from fed and starved rats. This preparation, consisting mainly of proximal convoluted tubules was incubated with three major renal substrates, L-lactate, glutamine and oleate to study the dose dependence of substrate uptake rates f... | 499,217 | [
0.1487115,
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0.216583,
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0.1... |
Mechanistic and stereochemical studies on the glycine reductase of Clostridium sticklandii. | Clostridial glycine reductase multienzyme complex which catalyses the reaction: Glycine + ADP + Pi + 2H leads to Acetate + ATP + NH3 was solubilised and fractionated essentially according to the method of Stadtman [T.C. Stadtman (1970) Methods Enzymol. 17A, 956--966] into two components: protein A and 'glycine reductas... | 499,219 | [
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0.09386837,
0.111694,
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0.03042661,
0.12... |
I-125 photon absorptiometric analysis of bone density in patients with regular dialysis treatment. | The density of bone in the distal third of the radius is measured by I-125 photon absorptiometry in 38 RDT (Regular Dialysis Treatment) patients (19 mean and 19 women, age range from 17 to 65 years). In the majority of patients the bone density (BMC/W) is reduced. The clinical follow-up of dialysis patients demonstrate... | 499,224 | [
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0.4369219,
0.2345926,
0.2947509,
0.0919678... |
Specificity of immunoassays. III. Use of two antisera of differing specificities to improve the specificity of steroid immunoassay. | The specificity of immunoassays can be improved by using a second antiserum to bind substances that cross-react. Both theory and practice show that the effectiveness of the procedure is dependent of the complex interplay of the concentrations of the two antibodies, the concentrations of the three antigens involved (the... | 499,238 | [
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0.461888,
0.3781537,
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-0.1701... |
2:1 and phase 4 peri-infarction block. | A patient with acute inferior and anteroseptal myocardial infarction initially developed a 2 : 1 AV block with alternate conducted ventricular complexes showing aberrancy, and later Wenckebach-type, 2nd-degree AV block with aberrancy of the beats following a long diastolic pause. Intracavitary recording suggested that ... | 499,280 | [
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0.5451799,
0.1357113,
0.072311... |
Identification of autoanti-Thi-1 antibody in the sera of BALB/c mice immune to P1798 lymphoma. | The specificity was established for the anti-thymocyte autoantibody which appeared in BALB/c mice (BAA) during immunization to the P 1798 lymphoma. The results indicate that BAA is specific for the Thy-1 alloantigen of murine T cells. By immunoprecipitation of 125I-labeled A/J thymocyte surface antigens from freeze-tha... | 499,326 | [
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0.2124938,
0.2802175,
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0.1699056... |
Dihydralazine and catecholamine-synthesizing enzymes in spontaneous hypertension. | Dihydralazine treatment which lowered blood pressure in young rats from the Lyon Hypertensive Strain (LHS), did not change phenylethanolamine-N-methyltransferase (PNMT) activity, but decreased tyrosine hydroxylase and dopamine-beta-hydroxylase activities in the C2 medullary region. These data suggest that the increase ... | 499,352 | [
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Methods of analyzing dynamic responses of temperature-sensitive neurones. | Methods are described for analyzing the dynamic responses of temperature-sensitive neurones or receptors using a computer facility. The methods allow correlation of impulse frequency with temperature changes or with the rate of temperature changes independent of the time course of the temperature change. Different type... | 499,415 | [
0.1827662,
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... |
Formation of lung colonies by mouse ascitic teratocarcinomas. | Intravenous transplantation of teratocarcinomas resulted in the formation of colonies only in the lung. The lung colony system would be advantageous for the quantitative studies of differentiation of teratocarcinoma stem cells. | 499,429 | [
0.2171956,
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0.2425742,
0.07926622... |
Effect of removal of the Harderian glands on pineal melatonin concentrations in the Syrian hamster. | Peak melatonin levels which are normally present in male Syrian hamsters at 8 h after the onset of darkness in animals maintained under a light:dark cycle of 14:10, were significantly decreased following the removal of the Harderian glands. | 499,443 | [
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[Relationship of the antitumor action of cyclophosphamide and prednisolone to the sequence of their administration and to the intervals between administrations in methylcholanthrene carcinogenesis in mice]. | The relationship of the antitumor action of cyclophosphamide combined with prednisolone and sequence of and intervals between administrations was studied in C57Bl/bj mice at methylcholanthrene cancerogenesis. Administrations of the drugs was started from the 50th day of cancerogenesis. The best results were obtained in... | 499,478 | [
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0.2650114,
0.3831713,
0.7004748,
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-0.0337879... |
Danazol treatment of endometriosis: long-term follow-up. | Forty-nine women diagnosed as having pelvic endometriosis were treated with 800 mg of danazol/day for a mean duration of 6 months. The average length of the follow-up period was 78 months. Side effects were minimal, and regular ovulatory menses returned within 25 to 90 days (average 42 days). Forty-two (85.7% of these ... | 499,581 | [
0.009094479,
0.3276083,
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0.04054748,
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0.2872415,
-0.25531... |
Syngeneic lines of chickens. VI. Immunoglobulin allotypes. | In the course of study of alloantigenic immunoglobulin polymorphisms in 10 inbred chicken lines we detected 7 IgG allotypic specificities and 3 IgM allotypes. All birds in a given line possessed a unique combination of several IgG alloantigenic specificities (forming the phenogroup) which is presumably controlled by on... | 499,597 | [
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0.3728477,
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... |
Androgen-uterine interactions: an assessment of androgen interaction with the testosterone- and estrogen-receptor systems and stimulation of uterine growth and progesterone-receptor synthesis. | This study investigates growth and the induction of progesterone-receptor synthesis in the immature (day 20--23) rat uterus after injection of different doses of 5 alpha-dihydrotestosterone (DHT) and testosterone (T) in long- and short acting injection vehicles. Moderate doses of T (300 microgram/day in saline for 3 da... | 499,651 | [
0.04984,
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0.1465798,
0.232522,
0.5019392,
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0.0... |
Cholesterol and bile acid metabolism in moderately advanced, stable cirrhosis of the liver. | We have selected for this study a well-defined group of patients with moderately advanced but compensated alcoholic cirrhosis. They were well-nourished and had no ascites, varices, azotemia, or encephalopathy. Liver biopsy showed little or no necrosis and inflammation despite wide-spread fibrosis. Serum bilirubin, tran... | 499,706 | [
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0.3356847,
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0.0347576,
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... |
Idiopathic familial cirrhosis and steatosis in adults. | A family was studied in which three middle-aged siblings had unexplained cirrhosis and steatosis. Five of nine additional family members had abnormalities of liver function. Liver biopsy in those 5 revealed steatosis in 3, steatosis and fibrosis in 1, and increase in lipofuchsin pigment in another. Detailed investigati... | 499,708 | [
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0.07207415,
0.1865293,
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0.5073443,
-0.4931855... |
Genetic variability and divergence in grayling, Thymallus arcticus. | In North America there are two disjunct forms of grayling, Montana and arctic, which have been separated for approximately 75,000 to 100,000 years. Electrophoretic analysis of thirty-six protein loci in these forms has revealed: (1) levels of gene duplication comparable to other salmonids, (2) a level of heterozygosity... | 499,766 | [
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The Munchausen spectrum: borderline character features. | In this paper the author presents a continuum of disease simulation that ranges from hysteria to malingering, with a range of relative unawareness to awareness of producing such deception. Focus is on the particular group of patients who consciously and repeatedly simulate disease. The frequency and form of such diseas... | 499,769 | [
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Consultation-liaison psychiatry: past failures and new opportunities. | Although the concept of liaison psychiatry is not new, progress in its development has been slow. Obstacles to its development are examined and new prospects discussed in light of combined economic, political, and social forces which provide the opportunity for an expanded scope of clinical, teaching, and research acti... | 499,772 | [
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Into the breach: emergency psychiatry in the general hospital. | In its position at the interface between the community and the general hospital, the emergency ward (EW) serves to reconcile the complex needs of the local population with the traditional organizational structure of the hospital. In recent years, the EW has been faced with the dilemma of managing increasing numbers of ... | 499,773 | [
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Cancer and suicide. | Issues of suicidal ideation, life-threatening behavior, and vulnerability in cancer patients are addressed. A review of pertinent literature is presented, including the areas of: suicide as a taboo topic; incidence of suicide in cancer patients; identifying patients' suicide potential; and suicide as coping behavior. C... | 499,780 | [
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Coping with illness by a concentration camp survivor. | A 54-year-old concentration camp survivor was observed during her third medical hospitalization in the past 3 months. The meaning of her illness leads to a symbolic reexperience of her traumatic past. Typical features of the Survivor Syndrome are reviewed and compared with the patient's symptoms. Coping mechanisms and ... | 499,788 | [
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[Human chromosome polymorphism and disordered reproductive function. I. Routine chromosome variants]. | Routine polymorphic variants of chromosomes of 58 married couples with reproductive failure (two or more spontaneous abortions, stillbirths and malformed children) and 48 control couples, having two or more normal children and no spontaneous abortions and stillbirths, were investigated by conventional staining techniqu... | 499,804 | [
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0.182... |
[B-scan echography in eye and orbital diseases]. | After a short description of ultrasound A- and B-scan-techniques, the ultrasonic findings in the different diseases of the eye and orbit are discussed. The results, as presented in this paper, show that ultrasound proves to be a useful aid in the evaluation and differential diagnosis of ocular pathology. | 499,968 | [
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rT3 production in normal man, assessed from variations in serum rT3 during short-term rT3 infusion. | The metabolic clearance rate (MCR) of 3,3'5'-triiodothyronine (reverse T3, rT3) was estimated in normal human subjects by a modified noncompartmental method using the integrated increase in serum rT3 following intravenous infusion of 0.10 nmol/min rT3 for 4 hr. The MCR-rT3 was calculated to be 102.8 +/- 17.01/day and t... | 500,002 | [
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Separation of the gonadotropic activity of crude choriogonadotropin from the inhibitory effect on lymphocyte transformation. | The effect of choriogonadotropin of different purities on the transformation of peripheral human lymphocytes was studied. Various crude hormone batches inhibited lymphocyte transformation in a dose-dependent manner, both in the mixed lymphocyte reaction and in the phytohemagglutinin-induced stimulation. The inhibitory ... | 500,013 | [
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Regionalized health systems in five nations. | As shown by the health care systems in five industrialized nations, the method of national medical care financing determines the extent of regionalization and the degree of hospital's autonomy. | 500,060 | [
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What to do when organized labor comes calling. | Many hospitals are finding that personnel management skills per se are not enough to successfully manage their employee relations functions. | 500,061 | [
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Partial trisomy 4 resulting from a complex maternal rearrangement of chromosomes 2, 4, and 18 with interstitial translocation. | A woman presented a complex chromosome rearrangement with translocation between chromosome 2 and 4 in addition to an insertion of the band 4q12 leads to q13 in the long arm of chromosome 18. The authors present a case study of the daughter who displayed the abnormal chromosome 18 and trisomy of band 4q12 leads to q13. | 500,092 | [
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Antibodies to the acetylcholine receptor in myasthenic dogs. | Antibodies to the AChR and anti-striational antibodies have been detected in dogs suffering from myasthenia gravis. The detection of these antibodies adds to the known similarities between the human and canine disease. This animal model will facilitate investigation of agents involved in the induction of spontaneous my... | 500,127 | [
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The effect of antiserum to eosinophils and susceptibility and acquired immunity of the guinea-pig to trichostronglyus colubriformis. | There is much experimental evidence to suggest that eosinophils are important in resistance to parasitic infection. We tested this hypothesis by treating guinea-pigs with rabbit anti-eosinophil serum (AES) and determining the effect of treatment on susceptibility and acquired immunity to Trichostrongylus colubriformis.... | 500,132 | [
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0.2980035,
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Fractionation and properties of glucans produced by Streptococcus mutans. | Water-insoluble (ISG) and water-soluble (SG) fractions of glucans produced by cell-free glucosyltransferase of Streptococcus mutans AHT (serotype g) were isolated by centrifugation at 20,000 x g for 15 min. No further resolution of slightly sonicated ISG was observed with gel filtrations on any Bio-Gel beads, including... | 500,192 | [
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Nature of the fructan of Streptococcus mutans OMZ 176. | The fructan of Streptococcus mutans OMZ 176 was shown to have a levan structure by comparing the chromatographic mobilities of the saccharides produced by partial acid hydrolysis of ghe fructan and known levan and inulin. This was confirmed by using concanavalin A as a lectin in a double-diffusion gel technique. | 500,214 | [
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Heterotoxicity of human serum. IV. Role of the alternative complement pathway and natural antibody in the lethal toxicity of human serum for mice. | The toxic and often lethal reaction caused by intravascular injection of fresh human serum (FHS) was studied in mice. Decomplementation experiments indicated that the alternative complement pathway plays an essential role in the production of 'serum shock'. In vivo activation of human factor B and C3, following the adm... | 500,231 | [
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Absorption of sustained-release and plain papaverine in man. | The concentrations of papaverine in the plasma of healthy volunteers were determined by a GLC-method both after single and repeated oral doses of plain and sustained-release drug formulation. In both experiments the AUC-value after the sustained-release drug form was significantly lower than after the plain papaverine ... | 500,258 | [
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Effect of frequent sun exposure on bacterial colonization of skin. | The bacteria colonizing the surface of the skin of a group of frequent sunbathers and a group of infrequent sunbathers were surveyed. Frequent sunbathing does not greatly affect the total number of organisms on the skin, but does tend to increase the proportion of bacteria containing carotenoid pigments. | 500,271 | [
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Observations with the "Bi-flo" cannula (continuous, single-needle haemodialysis). | Observations with the double-lumen "Bi-flo" cannula in chronic intermittent haemodialysis are reported. On the evidence of urea and creatinine measurements, recirculation of blood corresponds to 7.9 and 6.1 per cent, respectively. In comparison with double-needle or single-needle dialysis, use of the double-lumen cannu... | 500,302 | [
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Tunica vaginalis autografting for Peyronie's disease: an experimental study. | Groups of dogs were studied at varied intervals after autografting of tunica vaginalis from the testes to cover excised patches of tunica albuginea of the penis. Postoperative cavernosography revealed neither ballooning nor chordee. Histologically, the grafts were well accepted and uniformly merged with the neighboring... | 500,313 | [
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0.4386911,
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0... |
Therapeutic manipulation of Nb rat prostatic adenocarcinomas: chemotherapeutic evaluation of autonomous tumors. | Nb rat autonomous prostatic adenocarcinomas were transplanted into several groups of synergeneic Nb rats. Chemotherapy using 5-fluorouracil, methotrexate, Adriamycin, and cyclophosphamide was evaluated. Significance was seen with the use of these agents with varying doses. Cyclophosphamide and 5-fluorouracil treated an... | 500,317 | [
-0.1321019,
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0.3066976,
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Entrance of water into the bladder during sitz bath in elderly catheterized and noncatheterized females. | This study was conducted to determine if water enters the bladders of elderly catheterized and noncatheterized women during a sitz bath. Subjects were placed in a sitz bath containing fluorescein for 20 min. Serial urine specimens were collected at varying intervals up to 1 hr after the bath and compared to urine sampl... | 500,318 | [
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New control algorithms via brain theory. | New concepts and viewpoints are needed to develop control algorithms for large scale systems. It is hypothesized that brain functions in human beings clearly demonstrates the existence of superior techniques for controlling complex systems with multiple objectives. The theory of compacta is investigated as a basis for ... | 500,351 | [
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0.09957495,
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The pectoralis major myocutaneous island flap for reconstruction of the head and neck. | The anatomy, design, and blood supply of the pectoralis major myocutaneous island flap are described. This versatile, nondelayed flap has, for the most part, replaced the usual cutaneous flaps. Clinical examples of its use in head and neck reconstructive surgery are presented. | 500,365 | [
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Different aspects of membrane differentiation at the inner side (GERL) of the Golgi apparatus in rabbit luteal cells. | After luteinization, during the growth phase, rabbit luteal cells showed a well-developed Golgi apparatus, which was clearly reduced at the end of pseudo-pregnancy. During this whole period, acid phosphatase was demonstrated in the saccules (g) of the Golgi stack and in the innermost Golgi element (G2), which may be pa... | 500,396 | [
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... |
Heterogeneity in distribution of cardiac glycogen following isoproterenol infusions in the dog. | A combined biochemical, histochemical and cytochemical study was made of cardiac glycogen distribution following intravenous infusions of varying doses of isoproterenol in anaesthetized, open-chested dogs. There was a dose-dependent decrease in glycogen levels in biopsies of the posterolateral wall of the left ventricl... | 500,398 | [
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0.1120494,
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0.04114348,
0.3389527,
0.3310697,
0.002858327,
-0.12... |
Reflection versus fluorescence: a note on the physical backgrounds of two types of light microscopy. | Bright microscopic images against a dark background can be originating not only from fluorescence, but also from selective reflection. Selective reflection or scattering of visible light in microscopic preparations can be used for the visualization of sometimes otherwise barely distinguishable material. The images obta... | 500,404 | [
0.04332893,
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0.230345,
0.1314621,
0.03628504,
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0.1572716,
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0.1199213,
-0.04323248,
0.3268197,
0.5998955,
0.1754348,
-0.099012... |
Interaction of phenytoin with chloramphenicol or pentobarbital in the dog. | Two dogs that had been given phenytoin for control of seizures for approximately 1 year developed signs of phenytoin toxicosis (postural ataxia an d a hypermetric gait) when chloramphenicol was added to the therapeutic regimen. The signs of toxicosis disappeared within 24 hours after cessation of chloramphenicol treatm... | 500,438 | [
-0.4090425,
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-0.05116465,
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0.05044112,
-0.04164344,
0.1842319,
-0.2995704,
0.1680216,
0.1917118,
-0... |
Comparative approach to health maintenance: definition, need, and rationale. | A comparative approach has been employed in many phases of medicine, eg, epidemiology, surgery, nutrition, cancer. It has been used widely in teaching, research, and surveillance, but little attention has been paid to its application in delivery systems. Geographic and financial circumstances often create situations in... | 500,444 | [
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0.1117398,
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0.07909314,
-0.2277958,
-0.09057424,
0.120019,
0.245042,
-0.0785624... |
Diabetes mellitus in the juvenile dog: a report of four cases. | In four cases of diabetes mellitus in juvenile dogs, clinical and clinicopathologic findings were similar to those of juvenile onset diabetes mellitus in man. However, histopathologic findings varied from the usual findings in the human disease, and lack of plasma insulin was not proved in the canine cases. | 500,465 | [
-0.3726968,
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0.2161837,
-0.3059553,
-0.0289238,
-0.02182022,
0.036... |
Primary lymphedema of the hindlimb in the dog. | Congenital lymphedema was diagnosed clinically and confirmed radiographically in five dogs. In all dogs, hindlimbs were affected with painless pitting edema at birth or shortly thereafter. The absence of popliteal lymph nodes and lymphatic hyperplasia or lymphatic hypoplasia were detected by lymphangiography or necrops... | 500,466 | [
0.1835796,
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0.1955458,
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0.21165,
-0.07317726,
0.120306,
0.2131058,
-0.2353579,
-0.27422... |
A quantitative computerized recording method in clinical education: a pilot project. | This paper describes an approach to a quantitative computerized method for recording the clinical education experiences of physical therapy students. While the project was conducted in the field of physical therapy, it provides a model that can be adapted to other allied health fields. The objectives, methodology, outc... | 500,482 | [
-0.1847455,
0.07408513,
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0.1688578,
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0.04999637,
-0.3386012,
-0.1439933,
-0.03248054,
-0.1928423,
-0.12734... |
The time scale of tooth development and replacement in Xenopus laevis (Daudin). | One hundred and seventy two larval specimens of Xenopus laevis were reared in such a way that their rates of development (as measured by external criteria) were similar, and so the course of dental development could be examined histologically in a cross sectional study. In this way the events of tooth development were ... | 500,489 | [
0.1661988,
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0.3272729,
0.1244023,
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0.194436,
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0.2987478,
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0.4978814,
0.1469019,
-0.0008697447,
... |
Antitumor anthracycline antibiotics, aclacinomycin A and analogues. I. Taxonomy, production, isolation and physicochemical properties. | Aclacinomycin A and B, two major components of a new antitumor antibiotic complex, and their 19 analogues were produced by a culture of strain No. MA144-M1, which was identified as Streptomyces galilaeus. They were isolated by chelation with copper ion and silicic acid chromatography, and characterized by physicochemic... | 500,500 | [
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0.02279214,
0.1774245,
0.03078087,
0.4950909,
-0.1392981,
-0.2450685,
0.4... |
Liquid chromatographic determination of desoxycorticosterone acetate in oil injections. | To determine desoxycorticosterone acetate in oil injections, reverse phase partition chromatography on silanized, purified siliceous earth was used to separate the corticosteroid ester from the bulk of the oil vehicle. The latter was retained on the column while the steroid and the sterol and triterpenoid fractions of ... | 500,532 | [
-0.1545774,
0.4064119,
0.2346212,
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0.1148619,
0.145533,
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0.06677403,
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-0.1242084,
0.1304756,
0.2494291,
0.3238174,
0.1312456,
-0.1038598,
0.0... |
Amphilphilic nature of spiralin, the major protein of the Spiroplasma citri cell membrane. | Spiralin could not be solubilized in the absence of detergents, and it was shown by charge-shift crossed immunoelectrophoresis that this protein was capable of binding detergents under nondenaturing conditions. These properties indicate the amphiphilic nature of spiralin, which therefore should be regarded as an intrin... | 500,570 | [
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0.1253377,
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0.3713212,
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0.4082361,
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0.09933966,
0.2172172,
0.2755839,
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-0.9604859,
-0.1218054,
-0.6149416,
0.1246177,
-0.005774034,
-0.01919435,
0.055422... |
Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum. | An enzyme having both UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal) pyrophosphorylase activities was purified to homogeneity from Bifidobacterium bifidum. The molecular weight of the enzyme was about 200,000 and it appeared to be composed of four identical subunits. The purified enzyme showed almost the same reacti... | 500,588 | [
-0.1195566,
-0.1469454,
-0.3185621,
0.09607048,
0.06261221,
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0.1686048,
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0.2626097,
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0.05636809,
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-0.3898532,
0.3203132,
-0.01882607,
-0.02189151,
0.4969532,
0.4518435,
-0.2166905... |
Separation and purification of a potent bactericidal/permeability-increasing protein and a closely associated phospholipase A2 from rabbit polymorphonuclear leukocytes. Observations on their relationship. | Two antibacterial proteins from rabbit polymorphonuclear leukocytes, a potent bactericidal cationic protein that increases the envelope permeability of susceptible gram-negative bacteria and a phospholipase A2, have been purified to near homogeneity by ion exchange, gel filtration, and hydrophobic interaction chromatog... | 500,619 | [
0.1107659,
-0.1369954,
-0.04974841,
-0.1124178,
0.02740614,
-0.2363728,
-0.1626939,
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0.3573129,
-0.04390074,
0.06321453,
-0.0194284,
-0.036302,
0.2210615,
-0.1568885,
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-0.6253318,
0.01299595,
0.1901102,
0.2220656,
-0.1071849,
0.01005058,
-0.0060341... |
DNA-dependent RNA polymerases from Acanthamoeba castellanii. Comparative subunit structures of the homogeneous enzymes. | The constituent polypeptides of the three classes of DNA-dependent RNA polymerase from Acanthamoeba castellanii were compared by several electrophoretic methods. Polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (SDS) reveals that a number of polypeptide components of the isozymes have identi... | 500,645 | [
-0.3443654,
0.2523807,
-0.1113063,
-0.1511303,
0.09113847,
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-0.2018646,
0.1823351,
0.2653419,
0.05537136,
0.0369451,
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0.04352037,
0.1847943,
0.009759241,
0.07143103,
-0.1100668,
0.02147741,
0.2690158,
-0.07126224,
-0.0147678... |
A kinetic model of protein synthesis. Application to hemoglobin synthesis and translational control. | We present a kinetic model of protein synthesis which encompasses initiation, elongation, and termination parameters. We have investigated the dependence of the total rate of protein synthesis and the size of the translating polysomes on each of these parameters and in particular on the level of active 40 S ribosomes a... | 500,683 | [
0.05477993,
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0.2466999,
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0.3169709,
0.1202,
0.2099817,
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0.05302071,
0.08420933,
0.07937727,
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0.02742276,
-0.05357553,
-0.00857222,
-0.1854479,
0.3301708,
0.4453194,
0.04068906,
-0.07303842... |
Isolation and characterization of two isomers of brain tetrasialogangliosides. | Two isomers of tetrasialogangliosides were isolated and purified to homogeneity from human, bovine, chicken, and cod fish brains by employing DEAE-Sephadex and Iatrobeads column chromatographies. The tetrasialogangliosides of human, bovine, and chicken brains appeared to be identical because they had identical mobiliti... | 500,707 | [
-0.0798931,
0.1920928,
0.3610614,
0.1131626,
0.1569559,
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0.1852251,
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0.03288677,
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0.04624143,
-0.04421197,
0.04642099,
-0.08729007,
0.4140709,
-0.2116852,
... |
Absence of a cleavable signal sequence in Sindbis virus glycoprotein PE2. | Partial NH2-terminal sequence analysis has been performed on some products that result from the translation of 26 S mRNA of Sindbis virus either in vivo or in vitro. In vivo products were obtained after pulse-labeling of virus-infected cells. In vitro products were obtained after cell-free translation either in the abs... | 500,711 | [
-0.3060943,
-0.3044318,
-0.2619652,
-0.1703151,
-0.01328665,
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0.3356516,
0.1267624,
0.1332227,
0.228736,
0.3056357,
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0.001567133,
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-0.5904233,
0.01355269,
0.2049012,
-0.2450556,
0.3474308,
0.1504583,
-0.03847344,
... |
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