title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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A rabbit model to study the biokinetics of radiopharmaceuticals in bone. | A technique is described using the rabbit as the 'animal model' to measure the rate of extraction of the bone-seeking agent, technetium labelled ethane-1-hydroxy-1, 1-diphosphonate (99Tcm-EHDP) following constant-rate infusion into the femoral nutrient artery. The extraction is shown to be approximately linear for a pe... | 520,357 | [
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Transverse CAT of the myocardium with 201 T1. | A new computerized axial tomographic (CAT) scanner (J&P Tomoscanner) which enables the transverse section viewing of any organ labelled by one of the monophotonic gamma-ray emitting racers commonly used in Nuclear Medicine, has been recently commercialized. Its abilities in visualising the 201 T1 labelled myocardiu... | 520,362 | [
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Age, sex, and hemisphrere asymmetry differences induced by a concurrent memory processing task. | Subjects in three age groups matched simultaneously presented pairs of visual words or geometric shape stimuli as belonging in a "same" or "different" category. No age effects were observed unless subjects were also required to repeat the sequence of the last three "same-different" responses immediately following each ... | 520,381 | [
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Effect of ergot alkaloids on serum prolactin in non-psychotic organic brain syndrome of the elderly. | A compound of ergot alkaloids (Hydergine-Sandoz) or placebo was given to sixty elderly nursing home patients with non-psychotic organic brain syndrome. Subsequent to 12 weeks of treatment, the mean serum prolactin of the drug was significantly lower than that of the placebo group. No correlation was found between chang... | 520,386 | [
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Age dependent changes in the sperm population and fertility in the male rat. | The entire reproductive tract was devoid of spermatozoa during the first 42 days of life. The first appearance of spermatozoa was detected in the caput epididymidis of 45-day old rats and in the cauda epididymidis of 52-day or older rats. The number of spermatozoa in the reproductive tract increased with age. The sperm... | 520,388 | [
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A questionnaire assessment of age differences in retention of recent and remote events. | Age-related differences in memory for recently and remotely dated events have been evaluated through questionnaire assessment. Results from previous studies employing the technique differ in the analysis of retrieval of recent and remote events. In attempting to reconcile extant results from the literature, the followi... | 520,389 | [
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The effect of verapamil on the gastrocnemius and soleus muscles of the cat in vivo. | The effects of verapamil on the force of contraction of soleus and gastrocnemius muscles of the cat were examined in vivo. The rapid intra-arterial administration of verapamil (100-800 micrograms/kg) produced a dose-dependent increase in the contractile force of soleus and gastrocnemius muscles stimulated supramaximall... | 520,414 | [
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Deformed optic nerves in coisogenic albino and pigmented C57BL/6J--c2j mice. | The incidence of deformed optic nerve (DON) in C57 BL/6J--c2J mice is similar to that of a pigmented substrain of Long-Evans rats and much less than that of an albino substrain of Sprague Dawley rats. C57BL/6J--c2J albinos have no more DON than do coisogenic black mice. This suggests that albinism is not a factor in DO... | 520,446 | [
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The importance of the terminal hemi-acetal group for the ionophoric properties of nigericin. | Opening of the terminal hemi-acetal in dihydronigericin drastically reduces the ionophoric properties of nigericin and dehydroxymethylnigericin with 6 intact heterocycles. This is shown by 2 complementary methods, first with a liquid membrane electrode system, secondly by testing their ionophoric activities in rat live... | 520,454 | [
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Regularly firing neurones in the rat suprachiasmatic nucleus. | The spontaneous discharge of some suprachiasmatic neurones in vivo and in vitro was found to exhibit a very constant interspike interval. In vivo these cells were comparatively rare and appeared to be mutually coupled. The findings are discussed in relation to coupled oscillator theories of circadian rhythm generation. | 520,464 | [
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In vitro esterification of plant sterols by the esterifying enzyme of the small intestine of rat. | The in vitro esterification of plant sterols, beta-sitosterol, campesterol and stigmasterol, by the esterifying enzyme of the small intestine of rat was studied in the presence of saturated and unsaturated fatty acids. Campesterol esterification was highest, followed by sitosterol and stigmasterol irrespective of the t... | 520,471 | [
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Oxygen permeability of the chorion in relation to diapause termination in Bombyx eggs. | Oxygen permeability of the chorion of the silkworm, Bombyx mori, was measured in relation to embryonic diapause. It did not change appreciably when the eggs were freed from diapause by being kept under long chilling. This finding suggests that the increase in oxygen permeability of the chorion is not a pre-requisite fo... | 520,489 | [
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Elimination and metabolism of dimethylnitrosamine (DMN) by Xenopus laevis and other amphibians. | The elimination of (14C)-DMN after i.p. injection into Xenopus was measured, as was the metabolism in vitro of (14C)-DMN by liver from Xenopus and 9 other amphibian species. In view of its rapid elimination from the body and low rate of metabolism by Xenopus liver in vitro, DMN is unlikely to be toxic or carcinogenic i... | 520,492 | [
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Chromatin fluorescence by pyronin staining. | Human, chicken and mouse cells from different tissues show a bright red-orange fluorescence of the chromatin after staining with pyronin Y. The possibility that intercalation of the dye into double helical nucleic acids accounts for this fluorescence pattern is briefly discussed. | 520,493 | [
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Effects of sham-pinealectomy, performed under white and red light, on the melatonin content of rat pineal glands. | Sham-pinealectomy, performed under different light conditons in newborn and adult rats, is followed by changes of pineal activity resulting in variations of melatonin content. The pineal glands of rats sham-operated under white light produce significantly less melatonin. In contrast, glands of rats operated on under re... | 520,503 | [
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Determination of acetaldehyde in human blood. | A method for the determination of acetaldehyde in human plasma by headspace gas chromatography is described. Chloralhydrate, an inhibitor of aldehyde dehydrogenase, is immediately added to the blood sample to prevent a rapid disappearance of acetaldehyde in the erythrocytes. | 520,504 | [
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[Changes in the bodies of trained and untrained subjects working to capacity and having different degrees of motivation]. | In conditions of enhanced motivation trained subjects performed a greater work and untrained ones--a lesser work than under ordinary motivation. The most stable parameters in regard to working to capacity were as follows: heart rate, minute respiratory volume, amount of oxygen consumption, amount of exhaled CO2, energy... | 520,611 | [
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Residential segregation of Spanish Americans in United States urbanized areas. | Residential segregation among Spanish Americans, whites and blacks is measured in the 29 largest U.S. urbanized areas. Results show that Spanish Americans are much less segregated from whites than are blacks and are less concentrated within central cities. Spanish-white segregation also tends to be much lower in suburb... | 520,640 | [
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Effects of thymus grafts in nude mice transplated with human malignant tumors. | The effect of neonatal thymus grafts implanted in nude mice previously transplanted with three different human malignant tumors - an adenocarcinoma of the colon, a malignant melanoma and a Burkitt's lymphoma - were studied. In all immunologically reconstituted animals tumord were rejected. Tumor rejection stated 2-3 we... | 520,648 | [
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Induction of macrophage lysosomal enzyme secretion by agents acting at the plasma membrane. | Cultured mouse peritoneal macrophages were shown to secrete the lysosomal enzyme N-acetyl-glucosaminidase (N-ac-Glu) in response to IgG-Sepharose and some other non-endocytosable particles without substantial release of the cytoplasmic enzyme, lactate dehydrogenase. The interaction with IgG-Sepharose was studied in som... | 520,650 | [
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A multicentre study examining the substitution of Trasidrex for the free combination of Slow-Trasicor and Navidrex-K. | A multicentre, open study of general practice patients with essential hypertension who were currently being treated with oxprenolol and cyclopenthiazide was undertaken in which the patients were transferred to Trasidrex for 12 weeks. Weight, blood pressure, heart rate and side-effects were assessed pre-trial and at 4-w... | 520,655 | [
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Benefits of immunization versus risk factors in tetanus. | The risk of tetanus is universal, but it depends on numerous factors (socio-economic, environmental and biological) which combine to determine the force of infection. Tetanus is a murderous and costly disease. Its morbidity has greatly regressed in industrialized countries (less than 1 case per 100,000, involving mainl... | 520,667 | [
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Gait electromyography in normal and spastic children, with special reference to quadriceps femoris and hamstring muscles. | Telemetered gait electromyography was used to investigate gait patterns and the phasic behavior of the quadriceps femoris and medial hamstring muscles in 26 normal children and 32 children with spastic cerebral palsy. The average child with spastic cerebral palsy was found to have a shorter stance phase than the normal... | 520,711 | [
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Long-term use and discontinuation of methylphenidate with hyperactive children. | The long-term effects of methylphenidate on the behavior and academic functioning of hyperactive children are described. 36 children having a positive response to methylphenidate entered a three-year follow-up study in which they were closely monitored physically, behaviorally and psychometrically. During this period 1... | 520,713 | [
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Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice. | The effect of phenobarbital on simultaneous induction of liver and lung tumors was examined in inbred DDD mice. Group 1 of newborn mice received a single intraperitoneal (ip) injection of dimethylnitrosamine (DMN) and after weaning they were given 0.05% phenobarbital solution to drink. Group 2 received an injection of ... | 520,754 | [
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Clinicopathological study of juvenile polyp. | Thirty-two cases of juvenile polyp were investigated for the clinical and pathological findings. This type polyps occured frequently in the first decade with male predominance. Melena and bloody stool were found in all cases, prolapse of the polyps in 28%, and spontaneous amputation in 9.4%. The duration of symptoms we... | 520,765 | [
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[The so-called massive edema of the ovary. A case report and review of the literature (author's transl)]. | One case of massive ovarian edema is reported in addition to other 20 cases published in the literature. A 17-year-old nulligravida girl had severe abdominal pain of 2 hours' duration. On laparotomy, the right ovary was enlarged and oophorectomy was performed. The ovary measured 5 x 7 cm. The external surface was gray ... | 520,783 | [
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[The bacterial contamination of epidural catheters with areobe and anaerobe germs in obstetrics (author's transl)]. | Following anaesthesia the tips of 105 epidural catheters were investigated for aerobe and anaerobe bacteria. In one case aerobe germs (staphycoccus epidermidis) and in three cases anaerobe germs (propioni-bacteria were isolated. In two further cases aerobic growth was suspected but not confirmed in sub-cultures. The co... | 520,786 | [
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0.21993,
0.25579,
0.0729719,
0.192... |
With the eyes of the mind: autoscopic phenomena in the hospital setting. | Autoscopy is a rare syndrome in which a person hallucinates a vision of himself, while retaining insight into the unreality of the phenomenon. Although a number of illnesses are associated with autoscopy, the most common causes are stress and fatigue. The medical, psychiatric, literary, and historical contributions to ... | 520,828 | [
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[Mutagenic alterations of antibody biosynthesis]. | The investigations of changes of antibody affinities were carried out with 182 immuned CBA mice under the influence of the mutagens. The mice were injected with ethylene imine and its derivatives, 6-azauridine, cyanurchloride, theobromine, glyoxal, at a dose of 100 mg/kg 2 days before, simultaneously and in 2 and 5 day... | 520,835 | [
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A new pattern of needle for microsurgical repair of nerves. | This paper describes the design for a microsurgical stainless steel atraumatic needle for primary suture of small peripheral nerves in which the epineurium is friable. The needle (manufactured by Dixey Instruments, U.K.) is curved with a spearshaped point and a small cutting edge on the concave surface. The rest of the... | 520,876 | [
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... |
[Therapy of hyperlipoproteinemia type IIa and IIb with etiroxate-HCl. Dose-response comparison]. | In the clinical study presented etiroxate hydrochloride was shown to have a pronounced cholesterol-lowering effect. The percentage decrease of cholesterol values during treatment with 40 mg daily was significantly greater than that during 20 mg daily. The mean decrease was 41.2% in patients with initial cholesterol val... | 520,990 | [
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Early and long-term prognosis after vasodilator therapy in the acute phase of myocardial infarction. | Cautious administration of vasocilator agents with careful hemodynamic monitoring may improve cardiac function in many patients with severe pump failure and cardiogenic shock complicating myocardial infarction. However, the immediate prognosis tends to improve only in a specific subset of patients, that is, those with ... | 520,999 | [
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... |
[Sex difference in the mouse milk spots, with special reference to its development and formation (author's transl)]. | As reported previously, the omental milk spots in the mouse are morphologically classified into two types; type I and II. Type II milk spots are distributed on the dorsal layer of the omentum, and they are more numerous in females than in males. The type II milk spots appear at first at 10 days of age, and then gradual... | 521,008 | [
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Changes of maternal and fetal pituitary-adrenocortical functions during human labour. | The results of maternal 11-hydroxycorticoid (11-OHCS) determination on blood obtained from four stages of 44 spontaneous labour cases showed a strong and time-related maternal adrenocortical activation during vaginal delivery. The high 11-OHCS level in the cord blood and the increase of the 11-OHCS concentration in the... | 521,017 | [
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... |
Adipose tissue cellularity in hypo-and hyperthyroid rats. | To determine adipose tissue cellularity in hypo- and hyperthyroidism, male rats were thyroidectomized after weaning (T) and injected daily with either 0, 0.1, 1.8 or 25 microgram of L-thyroxine/100 g body weight for 40 days. They were compared with intact controls (C). Both epididymal fat-pad weight and adipocyte diame... | 521,018 | [
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Endurance capacity for continuous effort in terms of aerobic and anaerobic fraction of oxygen supply. | Studies have been conducted on 13 young healthy adults of average fitness on endurance work of varying durations lasting for 2-31 minutes using bicycle ergometer. Aerobic-anaerobic fractions of oxygen supply during each effort was determined. The data from Astrand and Rodahl on aerobic O2--supply and duration in maxima... | 521,120 | [
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Antispasmodic activity of the tertiary base of Daucus carota, Linn. seeds. | A nitrogen containing base responding to Mayer's test and Dragendorff's reagent for tertiary bases has been isolated from the seeds of Daucus carota Linn. The effects of the base as its bromide have been studied on smooth muscles of ileum, uterus, blood vessels and trachea of different species of animals. The tertiary ... | 521,127 | [
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... |
The role of computerized tomography in the care of the injured. | The records of 377 patients with head injuries admitted to the South East Thames Regional Neurosurgical Unit in the two years following the introduction of the EMI scanner (computerized tomography) were examined. Each patient was assessed on the reason for transfer, the necessity for transfer, the safety of transfer an... | 521,152 | [
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Roadside care and rescue American style. | The development of an emergency services system in the USA is described, including the training of paramedical personnel. The increase in the survival rate of the severely injured appears to be impressive and it is suggested that lessons can be learned from the American system. | 521,160 | [
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Life-history interviews of aging gay men. | Homosexual men and women have seldom been studied by gerontologists and almost nothing is known about the lifestyles, pattern of development through the adult years, and the effect of homosexuality on aging. Fourteen gay men, ranging in age from fifty-five to eighty-one, were interviewed about their life history and ex... | 521,182 | [
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Reduction of beta-endorphin content in the rat pituitary after dehydration and adrenalectomy. | Both dehydration and adrenalectomy of rats caused a significant reduction of immunoreactive beta-endorphin in the pituitary gland. Beta-Endorphin in hypothalamus, however, was not altered in either dehydrated or adrenalectomized rats. | 521,207 | [
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Aminonitriles and aminothioamides related to natural amino acids. | N-p-Methoxybenzyloxycarbonyl and N-tert.-butyloxycarbonyl amino acid amides related to a series of natural amino acids were dehydrated to the corresponding Meoz- and Boc-alpha-aminonitriles. Deprotection of the latter derivatives afforded alpha-aminonitriles related to alanine, tyrosine, phenylalanine, dihydrophenylala... | 521,208 | [
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The Ridley posterior chamber lens. | In summary, if used in the way I recommend, the Copeland lens gives excellent visual results and freedom from irritation. These results are sufficiently good that they need not be compared with the results of cataract surgery without implantation of a pseudophakos. It can be pointed out that these cases were all chosen... | 521,229 | [
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Studies on the use of blood lithium concentrations in lithium therapy in Japan. | The relationship between the concentration of lithium in whole blood and plasma was determined in 11 manic-depressive patients 12 h after the evening dose of lithium carbonate taken in the form of slow release tablets (Limas). Significant relationships were found between the concentration of lithium in whole blood and ... | 521,241 | [
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[Lithium balance in mania]. | Lithium balance studies were performed in 19 patients suffering from mania and 6 patients suffering from depression. The following results were obtained: (1) The mean daily requirement for lithium in the manic patients was 52 mM, in those with depression 30 mM (additional requirement in manic patients 73%). (2) Renal e... | 521,244 | [
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[Influence of diagnosis and length of hospitalization on the retest reliability for findings of the first psychopathological test (AMP system)]. | 80 inpatients were interviewed twice by the same physician with an interval of 24 h. By forming subgroups concerning diagnosis and duration of hospitalization, it was possible to examine the influence of these two criteria on the retest reliability of the following findings: (1) aspects of the interview; (2) AMP sympto... | 521,245 | [
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Rapid purification of human erythrocyte 6-phosphogluconate dehydrogenase by means of affinity chromatography. | A rapid two-step procedure is reported by which homogeneous 6-Phosphogluconate dehydrogenase can be isolated from human erythrocytes. This method is based upon direct affinity chromatography of the hemolysates on adenosine 2',5'-bisphosphate-agarose (yielding a 4,500-fold purification), followed by anion exchange chrom... | 521,257 | [
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Pica diagnosed by abdominal X-rays. | A young Arab woman with pica is presented. The diagnosis was suggested by the recurrent presence of numerous radiopaque particles in the course of the gastrointestinal tract. The particles changed location and concentration in successive abdominal X-rays taken at intervals of several weeks. Pica and its implications ar... | 521,265 | [
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... |
[Yellow-nail syndrome from d-penicillamine]. | The yellow nail syndrom consists of the triad of scleronychia (yellow nails), lymphedema and respiratory tract involvement. The nail changes include symmetrical involvement of finger and toe nails with regression of the nail sheath, paling of the half-moon, arrest of longitudinal growth, thickening, yellow coloration, ... | 521,278 | [
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0.05180321... |
Viral hepatitis B and Wiskott-Aldrich syndrome. | A 4-year-old boy affected by Wiskott-Aldrich syndrome had overt viral hepatitis B after repetitive blood transfusions. He was given immune serum containing HBs antibodies, with only transient improvement. The HBsAg titer decreased immediately after each administration of immune serum, but 2 days later it was higher tha... | 521,304 | [
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0.1252267,
0.2118295,
0.02614518,
-0.11805... |
[Rhinolalia aperta after the use of a postnasal pack as a medico-legal problem (author's transl)]. | A 23 year old patient needed a postnasal pack after tonsillectomy and adenoidectomy for control of severe postoperative bleeding. After removal of the pack on the sixth day, the patient had rhinolalia aperta. The patient could still swallow normally and there was no nasal regurgitation when swallowing solids or fluids.... | 521,331 | [
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0.06624953,
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... |
[Endoprosthetic closure of pharyngeal fistulae (author's transl)]. | The Häring endoprosthesis was originally designed for re-establishing an esophageal passage in patients with tumor stenosis of the esophagus. We have successfully used this prosthesis in two patients for closure of large pharyngeal fistulae following laryngectomy. The prosthesis provides a watertight closure of the pha... | 521,333 | [
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[The pathogenesis of tracheal stenosis following thyroidectomy (author's transl)]. | The frequency of trachealmalacia or stenoses following operations for struma or recurrent struma initiated our study of the pathogenesis of such changes. This study revealed that mechanical factors, such as compression of the trachea and the like, had been reported in the literature as the causative factors. The presen... | 521,335 | [
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Mesodiverticular bands as a cause of small intestinal strangulation and volvulus in the horse. | Volvulus of the jejunum and ileum in three horses was associated with intestinal strangulation in a mesenteric rent. The rent was in the jejunal mesentery at its point of attachment with an anomaly that was classified as a mesodiverticular band. The band also was attached to the dorsolateral surface of the jejunum, thu... | 521,351 | [
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Acute oral marijuana poisoning in the dog. | Ingestion of marijuana by three dogs in unrelated incidents resulted in depression-type toxicosis in each case. The most evident clinical signs were central nervous system depression and ataxia. Emesis and hypothermia were noted in two of the cases. Symptomatic and supportive treatment was accompanied by clinical impro... | 521,354 | [
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0.003358187,
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0.06977936,
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0.305652,
0.2743818,
0.03677246,
-0.07069683,
0.2900874,
-0.09498023... |
Serologic profile of exotic deer at Point Reyes National Seashore. | Serotests were conducted on axis (Axis axis) and fallow (Dama dama) deer at Point Reyes National Seashore to determine their status with respect to nine diseases enzootic to the native black-tailed deer (Odocoileus hemionus columbianus) or to resident dairy cattle. In the exotic deer, the proportion of animals that wer... | 521,370 | [
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... |
Funneling mechanism in hearing. | The funneling mechanism in hearing is reviewed and its underlying mechanism clearly elucidated. It is concluded that GABA is a principal candidate among the putative transmitters. | 521,396 | [
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0.05077244,
... |
Semautomated method for the analysis of chlorpheniramine maleate tablets: collaborative study. | A semautomated method for the analysis of chlorpheniramine maleate tablets, which is based on the USP XIX general assay for salts of organic nitrogenous bases, was collaboratively studied by 6 laboratories. Collaborators were supplied with 4 composites from 4 manufacturers. In the method, the active ingredient is disso... | 521,406 | [
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Screening method for vitamins A and D in fortified skim milk, chocolate milk, and vitamin D liquid concentrates. | Vitamin A was determined in fortified chocolate milk and skim milk; vitamin D was determined in fortified chocolate milk, skim milk, and vitamin D concentrates, using reverse phase high pressure liquid chromatography (HPLC). The sample is saponified, extracted with hexane, and chromatographed in an HPLC system on a 10 ... | 521,421 | [
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... |
A food satiation and oral hygiene punishment program to suppress chronic rumination by retarded persons. | Food satiation and oral hygiene punishment were used to treat the non-life-threatening rumination of two institutionalized profoundly retarded persons. Satiation consisted of allowing the clients to eat until a satiation criterion of food refusal was achieved or until two full meal portions were consumed. The oral hygi... | 521,432 | [
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0.3827154... |
Fate of newly synthesized histones shortly after interruption of DNA replication. | The synthesis and association of histones with chromatin were studied using MH-134SC cells in suspension culture. Cultures containing approximately equal numbers of cells were pulse-labeled with [3H]lysine at various times after the interruption of DNA synthesis with hydroxyurea. Each culture was mixed with a fixed vol... | 521,435 | [
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... |
An improved method for the preparation of chondroitin by solvolytic desulfation of chondroitin sulfates. | By heating the pyridinium salts of chondroitin 4- and 6-sulfates in dimethyl sulfoxide containing 10% of water or methanol at 80 degrees C for 1--5 h, several chondroitin preparations with sulfur contents of 0.02--1.05% were prepared in 83--96% yields, respectively. Chemical properties of the preparations, such as degr... | 521,436 | [
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0.009614382... |
Stem cell growth and differentiation in Hydra attenuata. II. Regulation of nerve and nematocyte differentiation in multiclone aggregates. | The differentiation of nerve cells and nematocytes from interstitial stem cells in Hydra has been investigated under conditions of changing stem cell density. Interstitial stem cells were cultured in a feeder layer system consisting of aggregates of nitrogen mustard-inactivated tissue. The aggregates were seeded with v... | 521,461 | [
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... |
Immaturity substances in Paramecium primaurelia and their specificity. | Cells of Paramecium primaurelia in the immaturity period of the life cycle contain substances which repress the expression of mating ability when introduced into mature cells. When the immature cytoplasm of P. primaurelia was injected into mating-reactive cells of P. tetraurelia, P. caudatum and P. multimicronucleatum,... | 521,463 | [
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... |
Detection of small amounts of human DNA in human-rodent hybrids. | A method of measuring semi-quantitatively small amounts of human DNA in irradiated human x mouse and irradiated human x Chinese-hamster somatic cell hybrids is described. One method uses molecular hybridization of cell DNA bound to nitrocellulose filters with a cRNA probe to Cot 0--1 human DNA. Alternatively hybrid cel... | 521,473 | [
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Structural changes in the pollinated and unpollinated avocado stigma and style. | Structural changes in the pollinated and unpollinated avocado (Persea americana Mill) stigma and style up to 42 h after first opening of the flower were investigated using light and electron microscopy. The pollen tubes grew in the stigma secretion and intercellular substance and initial contact occurred between the pl... | 521,474 | [
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Lack of correlation between interferon production of mononuclear cells and virus replication in chronic hepatitis B virus infection. | Interferon production in hepatitis B virus carriers with normal liver functions was preserved, whereas in carriers with chronic hepatitis it was depressed. The lower interferon production in hepatitis B virus carriers with chronic hepatitis appears to be the result rather than the cause of chronic hepatic disease. | 521,489 | [
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... |
Splenomegaly and splenectomy in sarcoidosis. | The natural history of 30 patients with sarcoidosis who showed histological evidence of granulomatous involvement of the spleen has been studied; 24 patients had splenomegaly, 16 of whom had splenectomy. The main indication for splenectomy was splenomegaly and resultant discomfort. Corticosteroids reduced spleen size b... | 521,496 | [
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... |
Regulation of energy balance in two models of reversible obesity in the rat. | Adult male rats were made obese either by tube feeding varying fractions (34%, 47%, 68% or 75%) of their normal food intake or by offering them a varied and palatable diet (cafeteria diet). After 17--30 days of these regimens, the treatments were withdrawn, and the animals were allowed free access to the normal stock d... | 521,518 | [
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0.4093589,
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Muscarinic receptor regulation of NG108-15 adenylate cyclase: requirement for Na+ and GTP. | Cholinergic agonists inhibit the basal and PGE1-activated adenylate cyclase activity in membranes isolated from the mouse neuroblastoma x glioma hybrid cell NG108-15. Inhibition is observed with acetylcholine, acetyl-beta-methylcholine and carbachol and is blocked by two specific muscarinic antagonists, atropine and qu... | 521,545 | [
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Discrimination learning of delinquent boys as a function of reinforcement contingency and delinquent subtype. | Previous research has demonstrated the effectiveness of contingency management as a means of behavioral resocialization with delinquent boys on an individual basis. The present study was designed to examine and clarify systematically verbal and token reward and/or punishment. The principal findings of the study were: (... | 521,567 | [
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... |
Accountability in health care: an essay on mechanisms, muddles, and mires. | This paper presents a critical evaluation of several theories of accountability and their applicability to health care concerns. The authors first provide a preliminary refinement of the imprecise concept of accountability itself and then examine four major types (political; bureaucratic; professional; and economic-con... | 521,611 | [
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Prediction of symptoms and illness behaviour from measures of life change and verbalized depressive themes. | A new measure of depressiveness in speech content and the Schedule of Recent Experiences are used to predict illness reports and clinic use in two samples of subjects. The results suggest that the more life change the subjects reported, the more depressiveness they verbalized, and that both life change and depressivene... | 521,621 | [
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0.239302,
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0.2057839,
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The dietetic and nutritional significance of textured vegetable protein (TVP). | A review of the limited success attained by TVP implies that it may be due partly to the failure of those manufacturing it to attain a sufficiently appealing aesthetic standard and partly to the fact that since its invention it has become apparent that protein deficiency, which would justify its incorporation in the di... | 521,629 | [
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Thymus and the endocrine system: ovarian dysgenesis in neonatally thymectomized rats. | By 10 days after neonatal thymectomy, the areas of lymphocytic depletion were being repopulated by plasma or reticular cells. Subsequently, ovarian dysgenesis was observed in 50-day-old thymectomized female rats as hyperplasia of ovarian interstitial cells an an enhanced degeneration of follicles. Thymectomized rats at... | 521,703 | [
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Relaxin inhibits spontaneous and prostaglandin-driven myometrial activity in anaesthetized rats. | Porcine relaxin (250 guinea-pig units/mg) infused intravenously into anaesthetized rats at 20 micrograms/h reversibly abolished spontaneous intra-uterine pressure cycles yet left the myometrium responsive to oxytocin in doses of 4--8 mu. The inhibition was found to be primarily of the frequency, rather than of the ampl... | 521,735 | [
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... |
Metabolism of testosterone by the epithelium and mesenchyme of the rat urogenital sinus. | Testosterone metabolism was measured in separated epithelium and mesenchyme from the urogenital sinuses of 17- and 19-day-old male and female rat embryos and compared with testosterone metabolism in the intact sinus. Both the epithelium and the mesenchyme converted testosterone to 5 alpha-dihydrotestosterone. The epith... | 521,737 | [
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Comparative studies of wild-type and cold-mutant (temperature-sensitive) influenza viruses: independent segregation of temperature-sensitivity of virus replication from temperature-sensitivity of virion transcriptase activity during recombination of mutant A/Ann Arbor/6/60 with wild-type H3N2 strains. | RNA 1 (see end of Summary) of a cold-adapted and temperature-sensitive (ts) influenza virus mutant A/Ann Arbor/6/60 has a different mobility from RNA 1 of wild-type (wt) A/Ann Arbor/6/60 when subjected to electrophoresis through acrylamide/agarose gels in the absence of denaturing agents. Detection of this lesion in RN... | 521,798 | [
-0.08818395,
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... |
Differentiation of the haemagglutinin genes of variant influenza viruses by RNA-RNA hybridization. | The genetic compositions of four antigenic variants of A/Memphis/1/71 (H3N2) influenza virus, which were selected by growth in the presence of monoclonal antibodies against the haemagglutinin, were compared. The results indicate that the mutant haemagglutinin genes can be differentiated by polyacrylamide gel electropho... | 521,805 | [
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Cytotoxic principles from the sap of Kalmia latifolia. | Examination of the sap of Kalmia latifolia has revealed Grayanotoxin I (1), phloretin (3), and 2',6'-dihydroxy-4-methoxyacetophenone (5) as cytotoxic components. Twenty-one dihydrochalcones have been synthesized and tested for cytotoxic activity. 2'3,3'4,4'-Pentahydroxydihydrochalcone (8) has been found to be cytotoxic... | 521,818 | [
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0... |
TLC-spectrophotometric assay of the main glycosides of red squill, a specific rodenticide. | Red squill bulbs, with reported specific rodenticidal properties, have been assayed for their content of the two main glycosides, scilliroside and scillaren A, by a method depending on the separation of the glycosides from purified plant extracts by tlc followed by spectrophotometric (uv and visible) determination of t... | 521,820 | [
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Immune response to isolated oligodendrocytes. | Oligodendrocytes were isolated from bovine white matter and were injected with complete Freund's adjuvant (CFA) into experimental animals. Indirect immunofluorescence studies using fluoresceinated goat anti-rabbit or anti-guinea pig immunoglobulin (GARIg; GAGPIg) showed that rabbit and guinea pig anti-oligodendrocyte (... | 521,826 | [
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0.06870394,
... |
Considerations on the operative results in a group of elderly neurosurgical patients. | 536 patients from 60 to 84 years old, operated on for neurosurgical lesions, are evaluated with reference to post-operative mortality rate related to the type of pathology. 83 deaths (15.6%) occurred in this series. Mortality rate increases progressively with advancing age. It is outlined that the aged patients have le... | 521,844 | [
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0.2857922,
0.3238789,
0.3632101,
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Motion and vision. I. Stabilized images of stationary gratings. | To demonstrate that eye movements have profound effects on the sine-wave contrast threshold, the author uses a new method of stabilizing the retinal image, in which the Purkinje reflections from the eye move the stimulus pattern displayed on a CRT screen. Calibration of this compensatory motion is very critical; a gain... | 521,857 | [
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The effects of dexamethasone on the cell kinetics of a murine malignant lymphoma. | The effects of dexamethasone on the cell kinetics of a rapidly growing syngeneic B cell malignant lymphoma in Balb/c mice have been studied. Growth curves, stathmokinetic studies and frequency of labelled mitoses (FLM) experiments were performed in groups of dexamethasone treated and control animals. These studies show... | 521,866 | [
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0.6017389,
0.5786261,
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The Tennessee Self-Concept Scale and the normal personality sphere (16PF). | An examination of the internal structure of the Tennessee Self-Concept Scale (TSCS) and the interrelationship among the TSCS scales and the secondary dimensions of the Sixteen Personality Factor Questionnaire (16PF) supported three conclusions: (a) The primary dimension underlying the TSCS is positive self-evaluation, ... | 521,891 | [
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0.2496712,
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... |
The effect of stimulation by meat on gastrins in pyloric antral mucosa of anaesthetized cats. | Chloralose anaesthetized cats were prepared with fundic and antral pouches. After stimulation with meat extract suspension in the antral pouches, the antral mucosae were collected, homogenized and subjected to subcellular fractionation to produce whole homogenates, debris, mitochondrial, granule and microsomal fraction... | 521,924 | [
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The properties of bovine lens membranes measured by a conventional double-chamber method. | 1. When the bovine lens was mounted in a divided chamber, an asymmetry potential of 4.3 mV (anterior face positive) was measured across the lens and values of 0.48 and 0.60 were obtained for P(Na)/P(K) of the anterior and posterior faces respectively.2. The half-times for the depolarization of the anterior and posterio... | 521,929 | [
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0.4189752,
0.01250834,
0.03407354... |
Differential conduction block in branches of a bifurcating axon. | 1. Propagation of action potentials at high frequency was studied in a branching axon of the lobster by means of simultaneous intracellular recording both before and after the branch point. 2. Although the branching axon studied has a geometrical ratio close to one (perfect impedance matching) conduction across the bra... | 521,937 | [
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0.4495468,
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0.3450294,
0.0... |
[Heat-induced salivary gland hypertrophy: change during chronic heat exposure (34 degrees C). (author's transl)]. | 1 A slight rise in ambient temperature (34 degrees C) increased saliva secretion in the rat and this was accompanied by licking behavior, thus increasing heat loss by evaporation. 2 The rise in ambient temperature was accompanied by a hypertrophy of the submaxillary glands (Fig.1, 2), arising from activation of seromuc... | 522,010 | [
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0.1550076,
0.2199815,
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[Splenic trauma complicating translumbar aortography : a report on 2 cases (author's transl)]. | Two very rare cases of splenic trauma following high translumbar aortography are described. Two types of clinical picture are observed : severe intraperitoneal hemorrhage, subcapsular and then intraperitoneal, from rupture of the spleen, and septic peritonitis following rupture of an intra- and perisplenic abscess. The... | 522,027 | [
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[Changes in angiographic recordings during reflux nephropathy (author's transl)]. | On one of the few occasions when it was possible to review angiographic recordings taken at five-year intervals, in a patient with reflux nephropathy, the authors use the results to emphasize that it is always very difficult to decide whether a small kidney, associated with reflux, is congenital or acquired. The reflux... | 522,031 | [
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... |
Improving drug compliance in general practice. | Patients of all ages make serious mistakes with their medicines, especially if several are prescribed at once.Taking medicines involves a great deal of physical and mental work. The best way to help patients take medicines accurately is to reduce this work by packing together all tablets taken at the same time of day. ... | 522,045 | [
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0.2224086,
0.2096141,
0.02781432,
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How much do patients know? A multiple choice question paper for patients in the waiting room. | A questionnaire about knowledge of personal preventive medicine, treatment, and the appropriate use of health services was put to a population of patients attending their doctors' surgeries. The population was probably biased toward the younger and those willing to fill in such a questionnaire. The results showed a soc... | 522,068 | [
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0.2828676,
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0.09492754,
-0.0173789... |
Frostbite arthritis. | We report a case of unilateral frostbite arthritis in a 58-year-old male. Clinical and radiological changes mimicked those of erosive osteoarthritis. Patients with this presentation should be carefully questioned for a history of exposure to cold, and frostbite arthritis should be considered in the differential diagnos... | 522,094 | [
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0... |
Precipitation membranes: III. Reversible changes of membrane properties induced by alterations in ionic concentrations. | The conditioned state of a precipitation membrane with its particular properties exists within a limited range of membrane potentials and requires certain minimum concentrations, Clim, of the generating ions in the adjoining solutions. We investigated these quantities for the BaSO4 cellophane membrane and found Clim to... | 522,126 | [
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0.197822,
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Modification of the Reichert FC-2 cryoattachment to improve ultrathin sectioning reproducibility. | Modifications of the Reichert FC-2 cryomicrotome attachment which facilitate sectioning of frozen material are described. Most valuable was the construction of a specimen holder chuck made of brass and connected to the specimen arm with a glass rod. Other changes include improved shielding from heat influx, a constant ... | 522,132 | [
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0.2942123,
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0.03691433,
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... |
Completion of the Viking labeled release experiment on Mars. | The final Labeled Release (LR) cycle on each Viking lander tested a surface sample that had been stored for several months at approximately 10 degrees C prior to the onset of the active sequence. At each lander site, activity was strongly diminished. This thermal sensitivity of the active agent on the surface of Mars i... | 522,152 | [
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0.107011,
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... |
Mars ultraviolet simulation facility. | A facility was established for long-duration ultraviolet (UV) radiation exposure of natural and synthetic materials in order to test hypotheses concerning Martian soil chemistry observed by the Viking Mars landers. The system utilized a 2500 watt xenon lamp as the radiation source, with the beam passing through a heat-... | 522,161 | [
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0.1264415,
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... |
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