title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Bone-marrow eosinophilia in the mouse. I. Eosinophil leukocyte levels in untreated mice. | The number of eosinophil leukocytes in the bone marrow of untreated mice (Cpb:SE) has been shown to vary widely. A systematic investigation of this variability is reported here. The study was done a) within a group of mice, b) within groups of mice at roughly 3-month intervals, and c) within a group over a time course.... | 577,086 | [
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Monozygotic twins with temporal arteritis and ophthalmic arteritis. | Temporal arteritis - ophthalmic arteritis occurring in a pair of monozygotic twins, who were 72 and 77 years of age respectively at the onset of symptoms, is reported. It is pointed out that it is rare to see, as in the first case, an improvement in an already existing severely reduced vision, in relation to corticoste... | 577,089 | [
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Effects on rat liver acetaldehyde dehydrogenases in vitro and in vivo by coprine, the disulfiram-like constituent of Coprinus atramentarius. | Coprine, the disulfiram-like constituent of the mushroom Coprinus atramentarius was found to inhibit the low-Km dehydrogenase in rat liver and to increase the acetaldehyde level in blood during ethanol metabolism in vivo. Coprine did not inhibit the low-Km enzyme in vitro, but the hydrolytic product of coprine, 1-amino... | 577,107 | [
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The renal handling of lithium: relation between lithium clearance, sodium clearance and urine flow in rats with diabetes insipidus. | In order to study the renal handling of lithium, I examined the relation between the lithium clearance and the urine flow in rats which had hereditary lack of vasopressin production and which had been given a test dose of lithium. The two variables were altered by varying the sodium intake. Rats with a low, medium and ... | 577,109 | [
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The effect of calcium and beat interval on the contractile force and refractoriness of the isolated rat atrium in the absence and presence of nifedipine: a possible mechanism for the negative staircase phenomenon. | An increase in the calcium concentration of the Ringer solution increased the contractile force and reduced the effective refractory period of the isolated rat left atrium paced at a frequency of 60 per min. An increase in the frequency of stimulation decreased the contractile force (negative staircase) and reduced the... | 577,110 | [
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The effect of intracisternally injected ouabain on perilymph electrolyte concentrations. | A means for altering the ionic composition of perilymph utilizing the cochlear aqueduct and cerebrospinal fluid in chinchillas is introduced. A decrease in sodium and an increase in potassium concentration in perilymph was observed after ouabain was injected into cerebrospinal fluid. The time course of changes in the p... | 577,105 | [
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Respiratory and cardiovascular effects of 3-methylxanthine, a metabolite of theophylline. | The effects of 3-methylxanthine (3-MX), a major metabolite of theophylline in man, were studied and compared with those of theophylline in isolated preparations of human and guinea-pig airways, isolated guinea-pig hearts, and in anaesthetized cats. 3-MX was pharmacologically active, producing effects similar to those o... | 577,111 | [
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[Quantitative investigation of embryonal motor activity by ultrasonic time-motion technique (author's transl)]. | Using ultrasonic A and B-mode equipment (Kreta-Technik, gray-scale) 80 time-position scans of active embryonal movements were recorded in 60 pregnancies between 8 and 14 weeks of amenorrhea. The quantitative analysis of the echograms comprised 14 parameters of embryonal motility. The extent and the velocity of body exc... | 577,126 | [
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Unusual gonadal stromal tumor of the testis. Case report with ultrastructural observations. | Ultrastructual observations on an unusual gonadal stromal tumor of the testis in a 4-year-old boy with gynecomastia revealed that the tumor cells lacked the abundant smooth endoplasmic reticulum usually found in neoplastic and nonneoplastic Sertoli and Leydig cells. The cells were rich in cytoplasmic microfilaments, wi... | 577,131 | [
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Anti-androgen-therapy in pachydermia of the female larynx--a new therapeutic possibility. | Case-report about a 56 year old white female patient with pachydermia laryngis and hirsutism, successfully treated with cyproterone-acetate, a testosterone antagonist. The significance of androgenic hormones for the development of epithelial changes in the female larynx is emphasized. The administration of antiandrogen... | 577,141 | [
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[The relevance of anticholinesterase properties to toxicity and neuromuscular effects of sulpiride (author's transl)]. | N-[(1-Ethyl-pyrrolidin-2-yl)-methyl]-2-methoxy-5-sulf-amoyl-benzamide (sulpiride, Dogmatil) inhibits acetylcholinesterase of rat brain in a mixed-type manner (Ki 0.3 mM; Ki 1.8 mM) as well as serum cholinesterase of the rat competitively (Ki 0.37 mM). Using acetylthiocholine in concentrations below 0.1 mM and purified ... | 577,162 | [
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[Studies on the effect of drugs on somatosensory cortical evoked potentials (author's transl)]. | The effect of the following drugs in therapeutic doses on somatosensory cortical evoked potentials was studied: methamphetamine, chlorpromazine, imipramine, diazepam, phenobarbital, pethidine, and novaminesulfone. Physiological saline was used as control. Each of these compounds was studied in 5 healthy subjects. Three... | 577,166 | [
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[Drug accumulation and dose finding (authors' transl)]. | Accumulation following repeated doses is no individual behavior of a drug, but always happens if the rate of invasion of a drug exceeds its rate of evasion. Using parameters such as dosing interval and biological half-life of a drug, its rate of accumulation as well as the equilibrium drug concentration in the body can... | 577,170 | [
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Dynamic structure of lipid bilayers studied by nanosecond fluorescence techniques. | Molecular motions in liposomes of dipalmitoyl-phosphatidylcholine (DPPC) were studied by nanosecond fluorescence techniques. As a fluorescent probe for the hydrocarbon region, 1,6-diphenyl-1,3,5-hexatriene (DPH) was used. Time courses of fluorescence intensity IT(t) and emission anisotropy r(t) of DPH embedded in DPPC ... | 577,184 | [
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Triiodothyronine, thyroxine, and iodine in purified thyroglobulin from patients with Graves' disease. | Previous studies have suggested that there is an overproduction of triiodothyronine (T(3)) relative to thyroxine (T(4)) in patients with thyrotoxicosis associated with Graves' disease. To evaluate whether or not an increased ratio of T(3) to T(4) in thyroidal secretion could be contributing to this relative T(3) hyperp... | 577,211 | [
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Amyotrophic lateral sclerosis in a high selenium environment. | During a ten-year period, four cases of amyotrophic lateral sclerosis have been found in a sparsely populated county (population 4,000) in west-central South Dakota. The patients were unrelated male farmer-ranchers between 57 and 66 years of age, living within a 15-km radius of each other. The cases occurred in a regio... | 577,250 | [
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Reversible plasma and red blood cells volumes increases in acromegaly. | Plasma volume (PV) and red blood cells volume (RBCV) were measured in 76 normotensive acromegalic patients (42 males and 34 females) and compared with those of 28 controls on the basis of body surface. In untreated males PV and RBCV were significantly higher than in normals (P less than 0.001) and total blood volume (T... | 577,334 | [
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Stimulation of peripheral T3 formation by oral but not by intravenous glucose administration in fasted subjects. | Fasting is known to promote a shift in the conversion of thyroxine (T4), more being deiodinated to an inactive form, reverse triiodothyronine (rT3), and less to active triiodothyronine (T3). The mechanism behind this change is not known, but it has recently been demonstrated that the proportion of dietary carbohydrates... | 577,337 | [
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Variation and heritability of ocular dimensions. A population study among adult Greenland Eskimos. | Adult Greenland Eskimos from Umanaq town (age 15+) and villages (age 40+) were examined. Optical pachymetry, ultrasonic oculometry, corneal diameter and curvature measurements, and subjective refraction were performed in 5-600 persons. Frequent occurrence of primary angle-closure glaucoma motivated the survey. Age-, se... | 577,357 | [
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Photocoagulation in retinal venous occlusion. | Results of retinal photocoagulation therapy in 26 eyes with retinal branch vein occlusion (RBVO) and in 18 eyes with central retinal vein occlusion (CRVO) are presented. The final visual outcome in eyes with macular oedema (non-ischaemic type of occlusion) did not significantly differ from that reported in various untr... | 577,360 | [
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Argon laser treatment of exudative senile maculopathy. | Fourty-nine eyes with exudative senile maculopathy (ESM) have been treated with argon laser photocoagulation. Fluorescein angiography studies were done pre- and postoperatively. The follow-up time is 6 to 12 months after end of treatment. The results suggest a beneficial effect in selected cases of ESM. | 577,362 | [
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Chronic copper poisoning in sheep. III. The distribution of soluble copper- and zinc-binding liver proteins of lambs compared with adult sheep. | The distribution of copper and zinc among soluble hepatic proteins in lambs from 1 normal and 1 copper dosed ewe was studied by gel filtration. It was found that the distribution pattern is similar in newborn lambs and transfer and accumulation of copper is possible in lambs. | 577,370 | [
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Behavior of rats in various stages of the sexual cycle after injection of noradrenaline into the lateral ventricle of the brain. | The influence of intraventricular injection of 50 microng of noradrenaline (NA) on behavior of female Wistar rats in various phases of the sexual cycle, and the influence of 17-beta-estradiol and progesterone in castrated female rats were studied. Changes in motor and exploratory activity were observed in the course of... | 577,387 | [
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Cellular leiomyomas of the stomach in 49 patients. | The cellular leiomyoma of the stomach is composed of tightly packed, generally uniform spindle cells arranged in palisades, whorls, or interdigitations. Although these neoplasms have been variably considered to arise from gastric smooth muscle or Schwann cells, the morphogenesis is incompletely resolved. Perhaps they d... | 577,393 | [
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[Pharmacological effects of piprozoline on bile secretion in dogs (author's transl)]. | Ethyl (Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)-acetate (piprozoline, Gö 919, Probilin) and its main metabolite Gö 3284 induce a strong choleretic effect in dogs after i.v. and i.d. administration as well. Intestinal absorption is fast, and already 3.5 min after administration of the substances a rise of t... | 577,408 | [
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[Studies on the influence of piprozoline on the microsomal enzyme system of the rat liver (author's transl)]. | Studies of hexobarbital sleeping time in rats showed that only a very high dosage of ethyl(Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)-acetate (piprozoline, Gö 919, Problin) (500 mg/kg) produced a weak interaction with the metabolism of hexobarbital; no signs of any induction of the oxidative enzyme system we... | 577,415 | [
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Pharmacokinetics as an aid in the interpretation of toxicity tests. | A method is described which makes the detection of alterations in the pharmacokinetic profile possible when substances are administered during long-term toxicity tests. By superposition of a radioactive dose at the end of the toxicity study a blood level can be obtained which--on the assumption of first-order kinetics-... | 577,420 | [
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0.272914,
-0.001711654,
-0.0... |
[Biopharmaceutic investigations with D-norpseudoephedrine (author's transl)]. | The concentrations of D-norpseudoephedrine in the plasma of 6 healthy persons were measured after the oral administration of 60 mg D-norpseudoephedrinehydrochloride in a hard gelatin capsule. One-compartment open-model parameters were derived from the blood levels. No gastric absorption was observed. The intestinal abs... | 577,442 | [
-0.4361113,
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0.1597068,
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0.02787818,
0.4483583,
0.08355881,
0.1677065,
-0.1... |
[Therapy with coronary dilators]. | The pathophysiological basis of antianginal therapy with vasodilating agents is critically reviewed. The concept of specific coronary vasodilation should not be pursued in the search for new antianginal agents. Although controlled clinical trials with coronary vasodilators in patients have been successful, no inference... | 577,451 | [
-0.4037604,
0.2669149,
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0.3392962,
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0.1224585,
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0.00002350033,
0.1877835,
0.1674043,
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0.1498646,
0.05763901,
0.2051275,
0.04523676,
0.07813951,
-0.138177... |
[Long-term infusion technique via tail vein in unrestrained rat. Technical short communication (author's transl)]. | A technique is described that allows tail vein infusion in the rat up to several weeks without the risk of pressure necrosis of the tail. By the aid of a simple metallic device the catheter is protected against damage by the animal. Since this armament is well tolerated and the mobility of the rat remains unimpaired, p... | 577,466 | [
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0.2131106,
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0.05954045,
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0.1662363,
0.09423792,
0.2798307,
0.1816326,
-0.1100396,
0.1271738,
... |
Absorption studies with the anti-diarrhoeal agent ethacridine lactate in laboratory animals and man. | Tritiated 2-ethoxy-6,9-diaminoacridine (ethacridine lactate, Rivanol) has been orally administered to rat, dog, rabbit and man, and the distribution of radioactivity between urine and faeces determined. Complete recoveries of radioactivity were obtained from rat, rabbit and man. From direct measurement of levels of rad... | 577,467 | [
-0.2070213,
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-0.2563801,
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0.3596245,
0.4178798,
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0.4277317,
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0.1842605,
-0.02312765,
0.1591213,
0.3015507,
... |
More evidence for the recessive inheritance of selective adult type lactose malabsorption. | Selective adult type lactose malabsorption appears in childhood or adolescence because of the great decline in jejunal lactase activity. There is strong evidence that this is a genetically determined disorder. Specifically, selective adult type lactose malabsorptions seem to be inherited by a single autosomal recessive... | 577,485 | [
-0.07856055,
-0.4085137,
-0.0719524,
0.03591365,
0.2547061,
-0.3219932,
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-0.3128644,
-0.03068547,
-0.1096133,
0.1320977,
0.3044907,
0.0972507,
0.03325678,
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-0.479395,
0.009163384,
-0.09081568,
-0.1104288,
0.02315154,
0.3825067,
-0.0223215... |
[Needle biopsies of sarcomas of the breast: cytomorphology and DNA cytophotometry (author's transl)]. | When needle biopsies are done on all palpable changes in the breasts, some sarcomas of the breast can be found. The cytomorphology of this mesenchymal tumor is described and the differential cytology is discussed. In some of our cases the relative content of DNS of the cell nuclei in the smear was determined by quantit... | 577,486 | [
-0.08867799,
0.2521699,
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-0.280437,
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0.2135029,
0.491303,
0.05130083,
0.09267578,
0.07699557,
-0.2783827,
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0.07487629,
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0.1318156,
0.4192348,
0.6427364,
-0.1669635,
-0.2504016,
... |
Imaging of spontaneous canine tumours with ammonia and L-glutamine labeled with N-13. | Ammonia and 6-glutamine, labeled with N-13, were tested as imaging agents for a variety of spontaneous canine tumors. The imaging capabilities of these compounds were compared with each other, with other scanning agents, and with radiologic and pathologic procedures. Good agreement between positive gamma images and pos... | 577,498 | [
-0.4100811,
0.3983958,
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0.04792642,
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0.01908733,
0.01202659,
0.4541771,
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0.4245231,
0.1704219,
0.01262902,
0.1149318,
0.1378413,
-0.2471176,
... |
Toxicity kinetics and clinical potential of subarachnoid lymphocyte infusions. | The feasibility of intrathecal lymphocyte infusions was examined since patients with gliomas are known to have circulating, tumor-specific, cytotoxic lymphocytes. Human (xenogenic) and syngenic lymphocytes were infused intrathecally into rabbits, and the toxicity and kinetics of the infused cells evaluated. Cerebrospin... | 577,502 | [
-0.2078348,
-0.2266537,
-0.4092542,
-0.5713006,
0.1201933,
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0.02810512,
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0.04975761,
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0.03182469,
0.2296788,
0.1462334,
0.04442273,
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0.2302903,
-0.1252723,
0.2127255,
0.09476091,
0.3923629,
0.335137,
... |
Bile acid deconjugation in intestinal obstruction studied by breath test. | Bile acid deconjugation was assessed by measuring specific activity of expired 14CO2 after the oral administration of cholyl-glycine-1-14C in 17 cases of intestinal obstruction, i.e. 15 mechanical and two paralytic. In the former, nine cases were operated and the remaining six cases were managed by the conservative tre... | 577,583 | [
-0.02264508,
-0.245763,
-0.05654735,
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0.05801358,
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-0.1770045,
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0.05366997,
0.1572624,
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0.4314694,
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-0.01976051,
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0.1647218,
-0.2182841,
0.1319134,
0.07497909,
0.266343,
0.1204595,
... |
[Preliminary results of treatment of hormone-dependent metastatic carcinoma of the breast with the bromocriptin-medroxyprogesterone acetate combination]. | A brief account of the concept of hormone dependence in breast neoplasia is followed by the presentation of results obtained with an association of medroxyprogesterone acetate (MAP) and 2-bromo-alpha-ergocriptine (CB 154) in 14 women with metastatic cancer of the breast, hormone dependent due to the presence of the cyt... | 577,604 | [
-0.1158073,
0.06057211,
0.187826,
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-0.06612042,
0.06226577,
0.02350149,
-0.2044494,
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-0.08775731,
0.1366861,
0.1262338,
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-0.1751378,
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0.4236086,
0.343576,
0.3214797,
0.2451014,
-0.1097919,
0.... |
Coeliac disease and goitre. | Two cases of coeliac disease associated with thyroid enlargement are presented. One had a large simple adenomatous goitre which was removed surgically and the other had histological confirmation of lymphadenoma (Hashimoto's disease). | 577,610 | [
-0.1320841,
-0.3060681,
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0.1479352,
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0.4817362,
0.04980526,
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0.2087066,
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0.0673362,
-0.05136211,
-0.2843118,
0.03782358,
0.08374622,
-0.124721... |
Metrizamide computed tomography cisternography: pediatric applications. | The methodology and clinical use of metrizamide (Amipaque) computed tomography (CT) cisternography are described as applied in the cases of 22 children with morphologic and physiologic abnormalities affecting the cranial portion portion of the central nervous system. In contrast to pneumoencephalography, CT cisternogra... | 577,613 | [
-0.2774859,
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0.01766833,
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0.2757354,
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0.6567925,
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0.3373188,
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-0.02815154,
0.1777499,
0.05575654,
0.06... |
[New strategies for prevention in adolescents and young adults]. | For various reasons, it is justified to revise the classical strategies of intervention concerning medical and social action to help young people. New behaviours such as drug addiction, for instance, have emphasized the inadequacies of the conventional means of treatment. Since 1970, Youth Advisory Services have appear... | 577,643 | [
-0.2118875,
0.4642426,
0.04831649,
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0.3617936,
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0.07753465,
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0.3511395,
0.05253625,
0.1786359,
-0.03529421,
... |
Amniotic fluid analysis in assessment of fetal maturity. | Sixty samples of amniotic fluid were analyzed for their surfactant level by measuring the lecithin-spingomyelin ratio and performing the "shake" test. Cytologic examination of the sediment was also performed using Nile blue sulfate staining. The lecithin-sphingomyelin ratio was found to be the best method to predict fe... | 577,657 | [
0.1328421,
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0.1133706,
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0.09388866,... |
Unusual events preceding hyperthyroidism with diffuse goiter. | Two unique patients with hyperthyroidism are presented here. A 48-year-old woman with a family history of Graves' disease was first evaluated and treated for a toxic adenoma with radioactive iodine. Three months later, she was again hyperthyroid, was found to have a diffuse thyromegaly, and was treated with radioactive... | 577,670 | [
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0.2539579,
0.4420196,
-0.1328188,
... |
Determination of cadmium in human milk during lactation. | During lactation, Cd-levels in human milk were determined by means of flameless atomic absorption spectrophotometry. The levels in colostrum were some 50-65% higher than in transitional and mature milk. | 577,685 | [
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0.1602739,
-0.02975065,
0.3024052,
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-0.1290051,
0.2729719,
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0.1078271,
-0.0... |
[Determination of the perilymph density in the cochlea of guinea pigs (author's transl)]. | The perilymph density of the sc. tympani, sc. vestibuli and the density of liquor cerebrospinalis in guinea-pigs are measured by determination from mass and volume of the fluid column in a glass capillary tube. For the density of perilymph in sc. vest. a value of (formula: see text) in sc. tymp. a value of (formula: se... | 577,702 | [
-0.045952,
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-0.06640446,
0.1110385,
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0.04195923,
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0.1600171,
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0.144288,
0.243726,
0.001281207,
-0.01790175,
... |
[Biopharmaceutic investigations with D-norpseudoephedrine. 2nd communication: Bioavaliability of a depot preparation (author's transl)]. | The concentrations of D-norpseudoephedrine in the plasma of five healthy male subjects were measured after oral administration of either two Fugoa depot aragees or of a standard of 60 mg D-norpseudoephedrinehydrochloride in a hard gelatin capsule. Areas under curves (AUC) were calculated with the trapezoidal-rule for b... | 577,875 | [
-0.3388072,
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-0.08705878,
0.01673459,
0.2009478,
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0.02927025,
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0.1348949,
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0.1503287,
0.2525581,
0.2317716,
0.06025182... |
On enzymatic clotting processes. I. Kinetics of enzyme-triggered coagulation reactions. | The kinetics of enzymatic clotting reactions such as the clotting of blood or milk, is analyzed. The appearance of a lag phase in the clotting is shown to be due to the difference in reaction order of enzymatic production and flocculation. The weight-average particle weight of the product formed is found to be a quadra... | 577,887 | [
0.07324914,
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0.09212373,
0.06178271,
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0.04151538,
0.1437973,
0.1842204,
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0.1517427,
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0.09774357,
0.3396657,
0.004845393,
0.4094234,
0.1902411,
-0.219262... |
Photography of peripheral pulmonary airway expansion as affected by surfactant. | Edges of excised lungs from twenty 27-day-old rabbit fetuses were photographed as tracheal pressure was raised and air entered alveoli. Lungs from two littermates were expanded simultaneously with pressure up to 50 cmH2O. The effect of surfactant (SA) on peripheal airway expansion was assessed by depositing 25 mul of S... | 577,922 | [
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0.002362454,
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0.07854614,
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0.02407877,
0.05232638,
0.3891134,
0.0741090... |
Pop bottle explosions. | To our knowledge, there are only two brief reports in the medical literature of injury sustained as a result of a carbonated soft-drink (pop) bottle explosion. We report three such cases and review pertinent data on this hazard. | 577,946 | [
-0.5474524,
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0.1631505,
0.3363125,
0.01856493,
-0.1592921... |
Use of 125I-fibrinogen kinetic data to detect disseminated intravascular coagulation and deposition of fibrin in patients with metastatic cancer. | A technique using computerized data handling for following the fate of 125I-fibrinogen through various physiological compartments is presented. Its use in detecting fibrin build up in patients with metastatic tumors and cancer-caused DIC is explained. An increase in j3u (fractional catabolic rate as seen in the urine d... | 578,029 | [
-0.1544042,
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0.4804963,
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0.3695296,
0.336266,
0.2425708,
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0... |
[Distribution of aflatoxin M1 in whey and curd during cheese processing (author's transl)]. | In model experiments on the distribution of aflatoxin M1 in whey and curd, the influence of the different processing steps was investigated. Taking the same weight ratio between whey and curd, the following results were obtained: a) The aflatoxin M1-distribution in whey and curd was not changed with increasing amounts ... | 578,049 | [
0.04332072,
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0.2572449,
0.1135484,
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0.3364623,
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0.1754395,
0.0926054,
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0.2132324,
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0.07019649,
0.3880816,
-0.01109403,
0.438078,
0.2288415,
-0.26806,
0.210... |
Secretin: high plasma levels in diabetes mellitus. | Plasma immunoreactive secretin levels were measured in 22 newly diagnosed non-ketotic, maturity-onset diabetics and 10 healthy control subjects during 50 gram oral glucose tolerance test (OGTT). The test was repeated in the diabetic group after 6 months' dietary treatment. At diagnosis the fasting secretin levels in th... | 578,060 | [
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0.1006015,
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0.03175695,
0.08746517,
0.02343436,
... |
A case of adrenogenital syndrome with aberrant 11beta-hydroxylation. | A 17 year old female patient with hypertension, amenorrhoea and hirsutism was found to have subnormal levels of plasma and urinary cortisol, significant plasma levels of Reichstein's compound S and 21-deoxycortisol, high urinary levels of THS and pregnanetriolone as well as elevated levels of plasma and urinary testost... | 578,062 | [
-0.2309111,
0.1458925,
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0.6645126,
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0.01811243,
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0.04277336,
0.2536528,
0.1682576,
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0.049745,
0.07201757,
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0.0230914,
0.1652395,
0.1852138,
0.3996384,
0.3569543,
-0.3941327,
0.0... |
[Some experiences concerning the effect of fetal respiratory movement (author's transl)]. | The effect of negative pressure by intrauterine respiratory movements of 115 fetal rabbits is examined between the 25th and 28th day of gestation. An intraamnial injection of Burri-ink with particles of the size between 20 and 50 nm and of a suspension of polyamid (size between 25 and 40 micrometer) in physiological Na... | 578,097 | [
-0.05019313,
-0.03085309,
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0.0922635,
0.1183757,
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0.275411,
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0.09986462,
0.1347794,
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0.02265466,
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0.0965186,
0.1900003,
0.2107233,
-0.1139255,
-0.0495847,
... |
[The problem of the ploidy reduction in carcinogenesis of the uterine cervix: numerical chromosome anomalies in carcinoma in situ (author's transl)]. | The authors report on cytogenetic studies of the uterine cervix in 11 carcinoma in situ. In six cases with intact epithelium the cells were no longer normal and five cases showed beginning stroma invasion. The numerical chromosome anomalies observed indicate the presence of ploidy reduction. In accord with cytogenetic ... | 578,101 | [
-0.04246138,
0.07098839,
0.1116123,
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0.1921473,
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0.451591,
0.2199998,
0.123245,
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0.08865201,
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0.1156864,
0.02307228,
0.5334692,
0.04972346,
0.02490971,
... |
Ventilatory and cholinergic control of pulmonary surfactant in the rabbit. | Four sets of experiments on surfactant secretion were performed using New Zealand rabbits under light pentobarbital anesthesia. Pa02, Paco2, and pHa remained normal during all experiments. In controls lung lavage yielded 1.62 +/- 0.26 (SD) mg of alveolar phospholipid (PL)/g lung; disaturated phosphatidylcholine compris... | 578,144 | [
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0.1520461,
0.1626969,
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-0.01122861,... |
Pulsating bubble technique for evaluating pulmonary surfactant. | Surface tension is determined with an apparatus which records pressure across the surface of a bubble, expanded in the sample liquid and communicating with ambient air. The disposable sample chamber, with a volume of 20 microliter, communicates with a pulsator and a pressure transducer. The volume displacement of the p... | 578,145 | [
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The relation between surface tension and area in the alveolar lining film. | 1. The properties of the rat alveolar lining film have been studied by observing the behaviour in a hanging drop, under reduced or increased ambient pressure, of bubbles derived from the lung.2. When such a bubble, covered by a metastable film of surfactant, is made to shrink, the material displaced from the surface us... | 578,153 | [
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The value of vaginal cultures in general practice. | One hundred and eighty high risk cases in a hospital special treatment centre and 50 low risk cases of vaginal discharge from general practice were investigated by the cultural examination of vaginal secretion. The results show this procedure is of value in diagnosing sexually transmitted diseases. | 578,154 | [
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Hematologic changes in a patient with Hodgkin's disease in relapse. | A patient with Hodgkin's disease also had anemia, hypochromia, and thrombocytosis, which were clues to an otherwise silent relapse. These features were corrected following chemotherapy. Repeated lymphangiography is shown to be of value in diagnosis. | 578,177 | [
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Estrogen treatment of postmenopausal women. Benefits and risks. | Estrogen treatment of postmenopausal women is effective in relieving the symptoms of vasomotor instability and urogenital atrophy; estrogen treatment is effective in preventing accelerated bone loss and osteoporosis in young women following castration, but in postmenopausal women aging is a more important determinant o... | 578,221 | [
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Megavitamins for minimal brain dysfunction. A potentially dangerous therapy. | Vitamin A intoxication as a consequence of megavitamin therapy for minimal brain dysfunction occurred in a 4-year-old boy. An early clue to diagnosis was provided by an abnormal bone scan. | 578,271 | [
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Renovascular hypertension as a cause of cerebrovascular accident in childhood: a case report. | Report on a 10 year-old boy with acute hemiplegia after an ischemic cerebrovascular accident, provoked by an unilateral renovascular disease with malignant hypertension, for which nephrectomy was carried out. The few publications pertinent to cerebrovascular complications in children with hypertension and the value of ... | 578,301 | [
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The use of metronidazole in the preparation of the bowel for surgery. | The preliminary results of this study have shown that a combination of oral phthalylsulphathiazole and metronidazole for preparation of the bowel for surgery reduces the incidence of postoperative infection compared with phthalylsulphathiazole alone. | 578,314 | [
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Immunoglobulins in serum and nasal secretion. A comparison between patients with aspirin hypersensitivity and allergic rhinitis. | Immunoglobulins A, E and G were studied in serum and nasal secretion from patients with allergic rhinitis, chronic rhinitis and aspirin hypersensitivity, and normal controls. The allergic patients differed from the other groups in having higher IgE values, both in serum and in nasal secretion. The patients with aspirin... | 578,350 | [
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The influence of the nictitating membrane on steroid inhibition of limbal wound healing. | In a study involving 34 rabbits, it was found that local corticosteroids inhibit limbal wound healing in normal rabbit eyes, and do not inhibit similar wounds if the nictitating membrane has been removed. It was further found that the contact time of fluorescein labelled corticosteroids is almost 3 times longer in rabb... | 578,366 | [
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Penetration of delta-9-tetrahydrocannabinol and 11-OH-delta-9-tetrahydrocannabinol through the blood-brain barrier. | The relative brain uptake (extraction into brain) of delta-9-tetrahydrocannabinol (delta-9-THC) and the primary metabolite 11-OH-delta-9-tetrahydrocannabinol (11-OH-delta-9-THC) was measured after close intracarotid injection in rats of radiolabelled moities using labelled antipyrine as reference. The extraction percen... | 578,377 | [
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Coagulant fractions of snake venom and the control of capillary bleeding during microsurgery of the ear in vivo demonstration. | In 398 cases of observed capillary bleeding out of total of 968 otological microsurgeries, the i.v. use of Bothrops Jararaca enzyme proved to be highly useful in controlling the bleeding in 79% of those, namely in 318 cases. We may assume that if capillary bleeding is indeed the consequence of some haemostatic deficien... | 578,416 | [
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1-Methyl-2-nitroimidazol-5-yl derivatives. IIIrd communication. | A series of 1-methyl-2-nitroimidazole-5-carboxaldehyde derivatives (substituted hydrazones, oximes and Schiff bases) have been prepared and tested for their antimicrobial activity. | 578,425 | [
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[Pharmacokinetic studies following administration of 14 C-D-penicillamine to rats]. | 14C-Labelled D-penicillamine [D-(--)-alpha-amino-beta-mercapto-isovaleric acid; Trolovol] was administered to rats in doses of 10 to 50 mg/kg body weight orally or i.v. A dose of 0.25 mg per rat was used for intra-articular injection (knee joint). 4 h after a single i.v. administration about 30% of the given amount wer... | 578,431 | [
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Papaverine blood levels after administration of a sustained-release preparation. Short communication. | The authors report the papaverine blood levels obtained after administration to a group of volunteers of a sustained-release preparation in comparison with a conventional form. The new preparation shows bioavailability equivalent to a normal papaverine but substantially more prolonged papaverine blood levels. | 578,446 | [
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Comparison of the anti-inflammatory activity of Commiphora mukul (an indigenous drug) with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant. | In the present investigation a method of induction of experimental arthritis in animals was modified to provide a better model replica of human arthritis. Inflammatory syndrome, resembling rheumatoid arthritis in man, was induced in the right hock joint of albino rabbits by intra-articular injection of the killed mycob... | 578,471 | [
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[The influence of the combination of coumarin and troxerutin on infantile blood parameter in lactation period. Short communication (author's transl)]. | The examination of the hematological parameters erythrocytes, hemoglobin, thrombocytes, thrombelastogram, prothrombin time, blood-clotting and bleeding time in 20 mothers and their infants proved that the combination of coumarin and troxerutin (Venalot) can be administered in elevated doses unhesitatingly. All values t... | 578,482 | [
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Absorption and excretion of carbenicillin indanyl sodium in patients with reduced kidney function. | On eight volunteers with reduced kidney function, 1 g of carbenicillin indanyl sodium was administered orally for the single dose studies and was given orally in a dose of 1 g every 6 h for 7 days for the multiple dose studies. The patients were divided into two groups according to their kidney functions: group I moder... | 578,496 | [
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Tetanus antibody production in serum and cerebrospinal fluid in the rabbit and correlated histopathological features of the central nervous system. | The histopathological features in the central nervous system (CNS) developing during the active phase of tetanus antibody formation in the cerebrospinal fluid (CSF) as induced in 15 rabbits were studied. The measurement of antibody titres in serum and CSF by electroimmunodiffusion and histological examination were done... | 578,524 | [
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0.157... |
Radioimmunoassay for normeperidine: studies on the N-dealkylation of meperidine and anileridine. | A sensitive and specific radioimmunoassay for normeperidine has been developed that can detect as little as 100 pg of this metabolite. In competitive binding experiments with [125I]O-tyramyl-normeperidinic acid and an antiserum produced in rabbits immunized with a bovine serum albumin-normeperidinic acid conjugate, mep... | 578,528 | [
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Pulmonary perfusion defect and bronchial artery collateral blood flow. | A five-year-old child with severe congestive heart failure following repair of tetralogy of Fallot was examined for correction of a suspected left-to-right shunt. Lung scan and selective bronchial angiographs demonstrated greatly diminished perfusion to the right upper lobe, which was supplied by a large bronchial arte... | 578,541 | [
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Immunestimulation in cancer patients by a new synthetic compound: BM 06 002. | A new synthetic compound 4-imino-1,3-diazobicyclo (3,1,0)-hexan-2-on (BM 06 002) has been shown in animal models to stimulate humoral and cell-mediated immune reactions. In a Phase I study in man a total absence of toxic side effects after intravenous injection of BM 06 002 has been demonstrated. In the present investi... | 578,572 | [
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Effect on intraocular pressure of retrobular injection of xylocaine with and without adrenaline. | The changes in IOP were registered in two groups, each comprising 30 patients, after a retrobulbar injection of Xylocaine and Xylocaine-adrenaline respectively. No significant difference between the mean values of the initial pressures and the IOP during the following ten min could be proved in either of the groups, bu... | 578,631 | [
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[Decidualisation of the endometrial stromal cell. An electron microscopic study (author's transl)]. | The fine structural changes of the endometrial stromal cell from late secretory phase up to full developed decidua cell have been investigated by means of electron microscope. During decidual transformation the cell volume, the assortment of cytoplasmic organelles and the mode of intercellular attachments undergo chara... | 578,672 | [
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... |
Acute lung lesions due to zirconium and aluminum compounds in hamsters. | The lung lesions produced by multiple short-term intratracheal instillations of saline solutions of sodium zirconium lactate (NaZL), zirconium-aluminum-glycine hydroxychloride complex (ZAG), and aluminum chlorhydrate (ACH) in hamsters were studied by light and electron microscopy. These solutions produced lesions begin... | 578,687 | [
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So-called pseudosarcoma of the esophagus: nodal metastases of the spindle cell element. | A polypoid lesion of the esophagus with all the morphological features of a so-called pseudosarcoma produced nodal metastases of the spindle cell element. Ultrastructurally, these spindle cells showed only fibroblastic features. The findings in this case and a review of cases reported as pseudosarcoma of the esophagus ... | 578,699 | [
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Neurobehavioral and systemic effects of longterm blood lead-elevation in rats. I. Discrimination learning and open field-behavior. | In order to assess neurobehavioral deficit subsequent to early low-level lead-exposure, Wistar-rats were prenatally Pb-exposed via their mothers, neonatally via their dams' milk, and later on via their diet containing lead acetate (745 mg Pb/kg diet). Blood-lead levels (PbB) of dams increased from 24.2-31.2 microgram-%... | 578,703 | [
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Mutagenicity testing in industry. | The aims of authorities, university and industrial scientists are outlined. The prime feature remains: How important are the achieved results for estimating the mutagenic risk to humans? The various methods available for the testing of chemical substances for mutagenicity are compared. Their usefulness to estimate the ... | 578,711 | [
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0.1290035,
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-0.1322223,
0.03702936,
0.125746,
0.1582737,
-0.4934317,
-0.07116979,
-0.5188801,
0.1948543,
-0.06826977,
0.3107345,
0.2549432,
0.2458346,
-0.1139254,
-... |
Validation of the in vivo somatic mutation method in the mouse as a prescreen for germinal point mutations. | The in-vivo somatic mutation method developed by us in an earlier X-ray experiment was tested for its usefulness in chemical mutagenesis work, specifically in the prescreening for germinal point mutations. In order to explore possible parallelisms, the 7 compounds chosen for study, as well as the genetic markers used, ... | 578,717 | [
0.08069146,
0.03424202,
-0.1699053,
-0.3670542,
0.5196267,
-0.3831396,
-0.03525421,
0.07252687,
0.09036101,
0.01761271,
0.1066632,
0.4508075,
0.1582353,
0.3368034,
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0.4107963,
0.3247641,
0.127322,
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... |
Binding of mercury and selenium in subcellular fractions of rat liver and kidneys following separate and joint administration. | The distribution of mercury and selenium has been examined in subcellular fractions of rat liver and kidneys in prolonged exposure to HgCl2 and Na2SeO3 administered separately and simultaneously. The molar ratio of mercury and selenium concentrations in subcellular fractions of the organs examined varied considerably. ... | 578,725 | [
-0.1825665,
-0.009893357,
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0.1471205,
0.04576636,
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0.1129845,
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0.2013137,
0.01716505,
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0.1815112,
0.08155323,
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0.2013299,
0.08861592,
0.2300895,
0.1545121,
0.1121874,
0.1152882,
-0... |
The nystagmus and the therapeutic effects on early-diagnosed cases of sudden deafness. | We investigated the hearing prognoses of early diagnosed cases of sudden deafness. We tried to find the most reliable factor to determine the prognosis of hearing loss. Of various possibilities that affect the prognosis; the period of onset to first examination, therapeutic manner and vestibular test findings, the find... | 578,735 | [
-0.2616465,
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0.1874748,
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0.1784138,
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0.09242761,
0.3899574,
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0.311694,
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-0.09670326,
0.2013731,
0.05925307,
-0.03... |
[Effect of the diuretic Etozolin in patients with normal and impaired renal function (author's transl)]. | The effect of the novel diuretic ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene) acetate (etozolin, Gö 687, Elkapin) on renal function and especially on the elimination of solutes has been investigated under clearance conditions on 25 hydrated patients with different glomerular filtration rates (GFR). On ... | 578,771 | [
-0.09459337,
0.3048927,
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0.3015333,
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0.001032364,
0.5541632,
0.2576188,
0.269921,
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0.2624024,
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0.2803195,
-0.105926,
0.1356924,
-0.08969887... |
[Comparative studies on the diuretic activities of Etozolin and a reference compound in normal volunteers (author's transl)]. | The novel diuretic (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)-acetic acid ethylester (Etozolin; Elkapin) has been investigated against a benzothiazide (Vs) and placebo on 8 volunteers. Etozolin and Vs show a dose dependent diuretic effect: 400 mg etozolin being equipotent to 75 mg Vs and 1200 mg etozolin b... | 578,772 | [
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0.3019975,
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0.1630559,
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0.3853894,
0.3271064,
0.06507992,
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0.09615193,
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0.2372508,
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0.08822174,
-0.07810... |
Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies: clinical description. | Carcinoma of the colon occurred in four generations of a family, including two of three siblings of one generation and eight of 19 members of the next generation. In addition, uterine cancer or lymphoproliferative malignancies were found in two family members. Of 41 members of the fourth generation, two were found to h... | 578,784 | [
-0.1413453,
-0.06757553,
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0.2439945,
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0.4523982,
0.1650011,
0.01220154,
0.0419376,
0.2668948,
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-0.06495813,
0.02419046,
0.4479257,
0.3673964,
-0.05941357,
... |
Alkaline phosphatase activity in the preimplantation mouse embryo. | Alkaline phosphatase (AP) activity has been assayed in frozen sections of preimplantation mouse embryos by an azo-dye cytochemical method. The results indicate that during preimplantation mouse development AP activity is first expressed between the 8- and 16-cell stages and develops in all cells by the late morula stag... | 578,810 | [
-0.1832732,
-0.197652,
-0.627327,
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0.2209409,
0.06966712,
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0.183719,
0.5197909,
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0.121678,
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0.08255752,
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0.3421295,
-0.3314721,
0.2298403,
0.2316115,
0.2100086,
-0.08662811,
0.... |
The ultrastructure of a porcine hereditary lymphoma with some observations on cell cultures and enzyme cytochemistry. | Ultrastructural studies have been made on affected tissues and cell cultures established from an hereditary lymphosarcoma of Large White pigs. Certain hydrolytic and lysosomal enzymes have been investigated at light microscope level in tumour cells and in cells established in culture. Morphological, behavioural and enz... | 578,812 | [
0.05820831,
-0.0198283,
0.06395184,
-0.06520285,
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-0.4119002,
0.114992,
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-0.02799288,
0.4445213,
0.1151864,
-0.05969953,
-0.03235837,
0.09879468,
-0.3528629,
0.3192439,
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-0.1698884,
0.2338683,
0.1732373,
0.199052,
0.2386009,
-0.1581411,
... |
Supplemented fasting as a large-scale outpatient program. | Although supplemented fasting is now established as an efficient means of achieving substantial weight reduction in massively obese persons, widespread application of this treatment is contingent on its successful adaptation to a large-scale outpatient regimen. Of 519 patients treated as outpatients, 78% lost a minimum... | 578,826 | [
-0.1150964,
0.2166708,
-0.3636286,
-0.04038893,
0.1437176,
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0.06273037,
0.1090416,
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0.02381826,
0.390083,
0.1667819,
0.08770934,
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-0.3752837,
0.1655637,
-0.177291,
0.1193038,
-0.188664,
0.2374836,
-0.0744153,
-0.00... |
Tricyclic plasma levels. Effect of age, race, sex, and smoking. | Steady-state plasma tricyclic antidepressant levels were determined in 65 patients undergoing treatment for depression with either amitriptyline hydrochloride or nortriptyline hydrochloride to determine if common factors such as age, race, sex, or smoking status were predictors of steady-state drug levels that have bee... | 578,829 | [
-0.02248828,
0.123073,
-0.4035037,
-0.5168705,
0.004383837,
-0.2058695,
-0.2815846,
0.1280157,
0.02198515,
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0.02248661,
0.1862512,
0.08065157,
0.4545582,
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0.02436651,
-0.2111179,
0.2927125,
-0.01700396,
0.1904494,
0.07380453,
0.4256504,
-0.09557131,... |
Triamcinolone aerosol. Treatment of aspirin-hypersensitive asthmatic patients. | The efficacy of triamcinolone acetonide aerosol in the management of asthma in six patients with aspirin hypersensitivity was evaluated during a one-year trial. Five patients were previously chronically dependent on systemic corticosteroids and had undergone unsuccessful trials with cromolyn sodium therapy. Substantial... | 578,832 | [
-0.08750579,
0.1837185,
-0.1679757,
0.07264665,
-0.1732945,
-0.09660784,
-0.3092439,
-0.08946016,
0.2043411,
-0.3014126,
0.06545333,
0.1347962,
0.240046,
-0.2797245,
-0.07837186,
0.05353868,
0.1402618,
0.1295485,
-0.1467224,
0.2381495,
0.2024955,
-0.01906637,
0.02305624,
... |
Microcytic polycythemia. Frequency of nonthalassemic causes. | A high RBC count combined with a low mean volume generally is attributed to thalassemia minor, either alpha or beta, or to polycythemia vera with iron deficiency. Among 330 patients with a mean corpuscular volume (MCV) less than 70 cumu, 35 had increased RBC counts. Of these, 26 had thalassemia minor and four had polyc... | 578,867 | [
-0.2794273,
-0.09490022,
-0.01780966,
0.006339235,
0.1239572,
-0.2889547,
0.002095778,
-0.1652935,
-0.1562926,
0.3494689,
0.2967052,
0.7360908,
-0.2023865,
0.279801,
0.142895,
-0.1926499,
-0.2478368,
0.2582684,
0.1986856,
-0.0002599495,
0.1709718,
0.03044474,
0.02131019,
... |
Leptospirosis in New England. | Although rarely reported in humans in New England, leptospirosis is enzootic in western and central Massachusetts. Recently there were three cases of Leptospira interrogans, serotype var pomona, in Easthampton, Mass. Our study and others indicate a potential for waterborne epidemics in humans. | 578,899 | [
-0.4177813,
-0.08705914,
0.09695037,
-0.01797727,
-0.1559752,
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0.2956282,
0.3274519,
0.4031212,
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-0.339195,
0.09042352,
0.1785419,
-0.2066786,
0.03167887,
0.1221827,
-0.20733... |
Examining the homosexual male for sexually transmitted diseases. | Homosexual men may be deterred from seeking an examination for sexually transmitted diseases because it would require an open admission of sexual preference. For these diseases to be controlled, gay men must be motivated to be examined for sexually transmitted diseases. If a medical or health professional feels unable ... | 578,904 | [
-0.2512672,
0.05382262,
-0.4280655,
0.142525,
0.1402284,
-0.2175369,
-0.1969717,
-0.3187023,
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-0.1215582,
0.2869529,
0.09762979,
0.01934851,
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-0.2918613,
-0.01843133,
-0.6724781,
0.08399395,
-0.1760337,
-0.1386739,
0.2220424,
-0.07842918,
0.1061516... |
Diagnosis and treatment of "verminous aneurysm" formation in the horse. | The clinical manifestations, diagnosis and differential diagnosis of "verminous aneurysm" formation at the root of the cranial mesenteric artery and coeliac artery resulting from Strongylus vulgaris larvae migration are described. Forty-nine of 57 cases were successfully treated with low molecular weight dextran (dextr... | 579,006 | [
-0.05384805,
0.1483655,
-0.1453405,
-0.1437077,
0.05949219,
-0.3653748,
-0.02236646,
0.08461767,
-0.1253444,
0.1404019,
0.2237369,
0.001758797,
-0.04540591,
-0.4850303,
-0.01432687,
0.1920435,
-0.4722874,
0.1317999,
-0.08836793,
-0.06789889,
0.1419569,
-0.01774517,
0.0033... |
Variations in uterine cytosolic oestrogen and progesterone receptor levels during the rat oestrous cycle. | The levels of cytosol receptors for both oestradiol and progesterone were simultaneous monitored in the uterus at various stages of the rat oestrous cycle. The use of the synthetic gestagen R-5020, with its high specificity and affinity for the progesterone receptor, eliminated interference arising from corticosteroid ... | 579,041 | [
0.1086344,
0.4443895,
0.02574923,
-0.1165613,
0.05473178,
-0.04769986,
-0.18142,
-0.1970038,
0.3015506,
0.4784656,
-0.05737,
0.06376684,
-0.05206122,
0.1969735,
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-0.2931933,
-0.1076223,
0.3313808,
0.02559161,
-0.06684958,
0.5437567,
0.02976395,
-0... |
Increased plasma binding and decreased blood cell binding of quinidine in blood from anuric rats. | The blood cell/plasma concentration ratio of quinidine, as influenced by the plasma protein binding, was studied in normal and anuric rats by applying incubation and equilibrium dialysis techniques on blood and plasma, respectively, from normal and anuric rats. The plasma protein binding of quinidine in anuria was incr... | 579,054 | [
-0.298317,
0.2952393,
-0.3337796,
0.07443327,
0.5282022,
-0.1423131,
-0.06408906,
0.1672941,
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0.0106249,
0.1807597,
0.2060217,
-0.01114363,
0.441695,
-0.4324134,
-0.01131241,
-0.41595,
0.3107594,
-0.3055187,
0.03288773,
0.2182767,
0.3812723,
0.06891466,
0.024... |
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