title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Morphological lesions in guinea pigs during skin exposure to 1,1,2-trichloroethane. | Guinea pigs were exposed to 1,1,2-trichloroethane applied directly on the skin of the back for periods between 15 minutes and twelve hours under anaesthesia. Morphological changes could be observed in the epidermis after 15 minutes and continued to progress during continuing exposure. The changes consisted of pyknotic ... | 579,060 | [
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Electrical activity of the rat uterus during early pregnancy and abortion. | Electrical activity of the rat uterus was recorded for 1 h daily on days 2--9 of pregnancy with 6 electrodes chronically implanted in the left uterine horn. In 10 untreated and 7 ergocornine treated rats, activity decreased in frequency and intensity during the first days of pregnancy. After day 3 activity was present ... | 579,066 | [
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Airborne micro-organisms and prevalence of byssinotic symptoms in cotton mills. | The concentration of airborne microbes, their endotoxins and the prevalence of byssinotic symptoms among workers were measured in the cardrooms of seven cotton spinning, a wool spinning and two cotton waste mills and in a dusty workroom of a group of five willowing mills, a tea-packing plant and a pipe tobacco factory.... | 579,071 | [
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False aneurysm of the descending aorta: a complication of umbilical artery catheterization. | A patient had an aneurysm of the descending aorta secondary to aortitis arising from umbilical artery catheterization and in association with coarctation of the aorta. The aortitis probably was the direct result of bacterial contamination of the umbillicus and catheter with Staphylococcus aureus and the placement of th... | 579,073 | [
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Injection into the extra-arachnoid subdural space. Experience in the treatment of intractable cervical pain and in the conduct of extradural (epidural) analgesia. | The anatomy and radiological appearances of the subdural space in the cervical region are described. Recognition of this space facilitates neurolytic injections for severe cancer pain in the distribution of the cervical nerve roots. The subdural space may have significance also in explaining the extensive sensory block... | 579,075 | [
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Freeze-fracture aspects of the junctional complexes in the round window membrane. | Replicas of the freeze-fractured round window membrane were studied in chinchillas. Morphologically identifiable zonulae occludentes were found between the cells facing the tympanic cavity and between the cells bordering the perilymphatic space. Gap junctions were only found between the perilymphatic cells. | 579,089 | [
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[A new model for demonstrating the hepatic first-pass effect (author's transl)]. | A procedure is reported for inserting chronically implanted vascular catheters into the hepatic vein, aorta and portal vein. Dogs are used as experimental animals. By rinsing the catheters daily it is possible to maintain their patency for months, thus permitting numerous test series. | 579,096 | [
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Hair embolism in lungs of rats after intravenous injection into caudal veins. | In case of intravenous injection into caudal veins of rats, the occasional inoculation of hair particles into the lumen of the vein cannot be avoided. These hairs either cause a local thrombophlebitis or are floated with the blood stream until they are thoughout caught by the pulmonary filters, even if they measure les... | 579,107 | [
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[Studies on the toxicity of thiaminedisulfide monoorotate. Short communication (author's transl)]. | The water soluble thiaminedisulfide monoorotate (thiooratin) was studied in mice and rats for its acute and subchronic toxicity. After continuous administration over 8 weeks no organic damages, in particular no fatty livers, were found. | 579,111 | [
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Antagonizing effect of aspartic acid on the development of physical dependence on and tolerance to morphine in the rat. | As free amino acids in the brain have a role in the development of physical dependence on and tolerance to morphine, and in the mechanism of action of some drugs, the effects of aspartic acid which antagonizes some effects of the single dose of morphine were studied during the development of the physical dependence on ... | 579,136 | [
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[On the determination of azapropazone from plasma by direct quantitative thin-layer chromatography (author's transl)]. | For the purpose of investigating drug interactions, a new selective method for determination of 5-dimethylamino-9-methyl-2-propyl-1H-pyrazolo[1,2-a] [1,2,4]benzotriazine-1,3(2H)-dione-dihydrate (azapropazone, Prolixan 300) was developed. The method is based upon the direct quantitation of the drug by thin-layer chromat... | 579,143 | [
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Biochemical studies on muscarinic receptors. | Muscarinic receptors have been characterized in smooth muscle and brain by the binding of reversible (e.g. atropine, quinuclidinylbenzylate) or irreversible (benzilylcholine or propylbenzilylcholine mustards) ligands. There is a close correlation between affinity constants derived from binding experiments and the affin... | 579,159 | [
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Behavioral nutrition: consumption of foods of the future by toddlers. | Behavioral measures of food consumption and tasting were combined with nutrient analysis of foods served at a toddler day-care center to determine whether children at the stage of initial exposure to adult diets would accept textured vegetable protein (TVP) and nonfat dry milk as well as they ate other sources of prote... | 579,180 | [
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Histochemical changes in striated muscle in patients with intermittent claudication. | Biopsy specimens from the gastrocnemius or rectus femoris muscle of 20 patients with intermittent claudication were studied using fresh frozen cryostat sections and histochemical reactions for adenosine triphosphatase, nicotinamide adenine nucleotide dehydrogenase reductase and phosphorylase and modified Gomori trichro... | 579,309 | [
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An exploration method of the Eustachian tube for intact and perforated drums: tubal-impedance-manometry. | The author describes an exploratory method of the Eustachian tube: tubal-impedance-manometry. This method comprises two types of techniques, the one applicable to patients whose eardrum is intact, the other to cases of tympanic perforation. The instrumentation and the examination techniques are described. The discussio... | 579,312 | [
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[A comparative ultrastructural-morphometric study of the cochlear spiral ganglion in rats and guinea pigs (author's transl)]. | The cochlear spiral ganglion of rats consists of 61.8% granular ganglion cells, 22.4% satellite cells and Schwann cells, 9.3% extracellular space, 4.8% myelinated nerve fibers and 1.4% filamentous ganglion cells. The granular ganglion cells consist of 76% cytoplasmic components and 24% nuclei. Their cytoplasm contains ... | 579,316 | [
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The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs. | Interictal spikes with a configuration similar to that occurring in grand mal epilepsy were generated by the application of penicillin to a hippocampal slice preparation. This slice preparation has potential value for screening anticonvulsant drugs and for studying epileptic activity. The effect of anticonvulsant drugs... | 579,341 | [
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Surgery of the thyroid gland. | Records of 92 patients operated on for thyroid diseases were reviewed. There were four histologic groups: adenoma-56 (61%), thyrotoxicosis-22 (24%), cancer-10 (11%) and Hashimoto's thyroiditis-4 (4%). Among the cold nodules, 9% were malignant. Routine frozen section examination revealed three cases of cancer and three ... | 579,347 | [
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Rare tumors of the intestines and rectum. | Some rare tumors of the intestines and rectum (eight cases) have been presented and discussed. All were successfully managed without operative mortality. I have presented some observations deduced from these cases which might aid in the diagnosis of such rare tumors--the importance of palpating the terminal ileum in an... | 579,349 | [
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Carcinoma in situ of the esophagus. | Although invasive carcinoma of the esophagus should theoretically begin as an in situ process, the latter is rarely seen in clinical practice. Two cases of carcinoma in situ of the esophagus were diagnosed at our institution. | 579,413 | [
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The development of periodicity of heart rate and respiration during sleep in newborn babies. | Polygraphic records of EEG, ocular movements, respiration, and heart rate were made continuously in 10 full term babies between 2 and 7 days old. Power spectral analysis was then computed for heart and respiratory rate. The period durations obtained by this method ranged from 20 to 70 minutes. Most of the power spectra... | 579,436 | [
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[Attempts to characterize a tumor specific inhibitor extracted from the maternal part of the bovine placenta]. | A fraction was isolated from the maternal part of bovine placenta, which significantly inhibits the incorporation of thymidine into the DNA of tumour cells. This factor has, however, only a limited effect on the same reaction in bone marrow cells or in fibroblasts. It is suggested that the factor enters the cell by an ... | 579,446 | [
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Relations between activation and inhibition of fibrinolysis in the walls of human arteries and veins. | From systematic studies of both the activation and the inhibition of fibrinolysis in human blood vessels, data which provided insight into the fibrinolysis antagonism along and across the human vessel wall were obtained. The capacity for fibrinolysis initiated by plasminogen activator in sections of human arteries and ... | 579,485 | [
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Increased activity of vitamin K-dependent clotting factors in human hyperlipoproteinaemia - association with cholesterol and triglyceride levels. | Levels of blood coagulation factors, cholesterol and triglyceride were measured in human plasma. Prothrombin was significantly elevated in type IIa hyperlipidaemia; prothrombin and factors VII, IX and X in type IIb; and prothrombin and factors VII and IX in type V. Multiple regression analysis showed significant correl... | 579,489 | [
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Heparin neutralizing activity (HNA) and antithrombin III in coronary artery disease. | Plasma from 14 patients with severe and diffuse coronary atherosclerosis has been compared with that obtained from a normal control group. While a decreased heparin-thrombin clotting time was demonstrated in the patient group, suggesting an increased level of circulating platelet factor 4, there was no significant alte... | 579,515 | [
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Comparative studies on the metabolism of oestradiol in the brain, the pituitary and the liver of the rat. | Radioactive oestradiol was incubated with homogenates of hypothalamus, pituitary and liver and slices of cortex, hippocampus, hypothalamus, pituitary and liver of ovariectomized rats. 2- and 4-substituted oestrogens were the main metabolites in the brain and were found in the same proportions. In the liver only the 2-s... | 579,525 | [
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Demonstration of platelet electrophoretic mobility slowing factor (PSF) in supernatants of human lymphocyte cultures stimulated by phytohaemagglutinin (PHA). | It has been demonstrated that human peripheral lymphocytes, stimulated with PHA, form or release a factor that slows platelet electrophoretic mobility (PEM). The factor is chromatographed on Ultrogel AC a 44, has a molecular weight of approximately 45,000, is stable on heating at 56 degrees C for 30 min, but is inactiv... | 579,539 | [
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The effect of phenytoin on the tissue concentrations of digoxin in the rat. | Rats treated chronically with digoxin were treated with two different dose levels of phenytoin, either as a single dose or chronically. Digoxin concentrations were measured by radioimmunoassay in the serum, urine, heart, muscle, liver, and the kidney. Chronic treatment with the high dose of phenytoin significantly incr... | 579,559 | [
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0.431469,
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0.05417439,
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0.2379697,
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0.06074355,
0.03265502,
0.2964224,
-0.1655522,
-... |
Detection of induced tumour-resistance to cyclophosphamide by the in vitro short term test. | Treatment of the solid Walker carcinosarcoma of the rat for a period of one year with cyclophosphamide (40 mg/kg at each passage; tumours were transplanted weekly) resulted in the formation of a cyclophosphamide-resistant tumour cell line. Without further treatment, animals injected with non-treated or cyclophosphamide... | 579,579 | [
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Symposium on peptic ulcer disease. 1. Medical treatment of peptic ulcer. | The conventional treatment of peptic ulcer disease with special dietary regimens, antacids or anticholinergics has been found wanting. Recently introduced agents show considerable promise in the benefit they can render. Carbenoxolone accelerates the healing of gastric ulcers by increasing gastric mucosal resistance. Ci... | 579,607 | [
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0.1140112,
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Oxygen-dependent chemical tumorigenesis in a Nicotiana hybrid: inhibition by ascorbic acid and dinitrophenol. | Aqueous solutions of molecular oxygen, per se, or in combination with either pyrogallol or 6-azauracil increased tumorigenesis in Nicotiana suaveolens X Nicotiana langsdorffii seedlings relative to control seedlings. The biological activities of the organic chemicals were O2-dependent, because the substitution of N2 or... | 579,609 | [
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... |
[1st case of eosinophilic meningitis in Reunion, probably due to Angiostrongylus]. | Report of the case of a six-year-old child who presented a meningitis with 40 % eosinophils in the cerebrospinal fluid and which spontaneously regressed. These clinical data and the serologic (positive test for many nematod antigens) and epidemiological findings (presence of Angiostrongylus larvae in terrestrial gaster... | 579,615 | [
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0.1227079,
0.0326134... |
Molecular basis of familial and acquired phagocytosis deficiency involving the tetrapeptide, thr-lys-pro-arg, tuftsin. | The biological activity and metabolism of the phagocytosis stimulating tetrapeptide (Thr-Lys-Pro-Arg) tuftsin, are discussed. Its effect is shown to be highly specific. It stimulates the phagocytic activity of the blood polymorphonuclear leukocyte. A unique familial deficiency of the tetrapeptide is described. In such ... | 579,629 | [
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... |
Unchanged incidence of bronchopulmonary dysplasia in survivors of hyaline membrane disease. | To test the hypothesis that decreased mortality from severe HMD will result in increased morbidity from BPD, chest films of 30-day survivors of severe HMD were reviewed for evidence of Northway's Stage IV BPD. During July, 1970 to June, 1971, 20 survivors of severe HMD were identified; one case of Stage IV BPD was foun... | 579,635 | [
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0.09857617,
... |
[Progress in the surgical treatment of cervix carcinoma]. | The radioisotope radical operation may cause an improvement of results in carcinoma of the cervix stage I b, II, and IV. The increased yield of lymph nodes enables a more reliable prognosis in advanced cases. Recurrent tumors at the pelvic wall may be detected earlier by isotope nephrography. | 579,655 | [
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0.29... |
Nonhyperoxic retrolental fibroplasia. | Retrolental fibroplasia (RLF) has most often been observed in preterm infants exposed to high ambient oxygen concentrations. This case report describes an infant near term who was never exposed to supplemental oxygen but in whom stage 4 RLF developed. The etiologic role of exchange transfusion is discussed. | 579,658 | [
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0.1678082,
0.3740892,
0.04098107... |
[Blood serum magnesium content and its excretion by the kidneys in thyrotoxicosis]. | A study was made of magnesium content in the blood serum and the urine of 62 patients with thyrotoxicosis before and after the parenteral administration of magnesium sulfate (load dose). Blood serum magnesium content was diminished; as to its renal excretion--it failed to differ from that in the control group. The ment... | 579,660 | [
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0.2901248,
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0.09563172,
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[Mean thickness measurement of distributed fine particles by using alpha-ray absorption curves (author's transl)]. | The mean superficial density of fine particles, such as polystyrene latex particles or ion exchange resin particles, dispersed on a thin supporting film was measured by means of the thickness gauge which used the absorption curves of alpha-rays. The measured absorption curves coincided with the ones calculated from the... | 579,665 | [
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0... |
[In vivo behavior of 111In-DTPA in rat and mouse after intra-ventricular administration (author's transl)]. | In vivo behavior of 111In-DTPA in rat and mouse after intra-ventricular administration was studied. Thus, 50 muCi and 35 muCi of 111In-DTPA was injected intra-ventricularly to rat and mouse respectively. At specific time intervals, the animals were sacrificed, then distribution in organs was determined by radioactivity... | 579,668 | [
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0.1633863,
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Structural modifications in contraceptive steroids altering their metabolism and toxicity. | Norethisterone and, to a lesser extent, d-norgestrel are metabolically activated by rat liver microsomal enzymes to intermediates which are capable of irreversibly binding to proteins. This microsomal activation in vitro depends on presence of NADPH and is inhibited by glutathione. Irreversible binding of metabolites o... | 579,976 | [
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0.0... |
Metabolic activation of diethylstilbestrol and aminostilbene-derivatives. | Diethylstilbestrol and trans-4-dimethylaminostilbene are metabolically activated and several of their metabolites are able to react with cellular macromolecules. Some of the problems are discussed which are encountered in linking a particular metabolite with the mutagenic and carcinogenic properties of these compounds. | 579,979 | [
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0.3263862,
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Spectrophotometric assay of nicotinic acid in blood. Assessment of its daily profile in humans. | A sensitive, simple, and specific spectrophotometric method is developed for estimating nicotinic acid in blood. The method depends upon reducing nicotinic acid by Zn/HCl to piperidine-3-carboxylic acid. The latter is complexed with CS2 and ammoniacal CuSO4 to form the yellow Cu-dithiocarbamate complex. The color is me... | 580,015 | [
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[Maltose as a substrate for inducing osmotic diuresis (author's transl)]. | 10 healthy men received an i.v. infusion of maltose at a dosage of 1.5 g/kg/h over a period of 1 h. No clinical side effects were observed. Total protein and albumin showed a significant drop. The glucose level remained constant. The concentration of maltose rose up to 495 +/- 77 mg/100 ml. The osmo-diuretic action of ... | 580,025 | [
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0.2418342,
0.25324,
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... |
The influence of D-penicillamine on cell proliferation. II. Quantitative investigations during a chronic proliferative inflammation in a model granuloma. | The influence of D-penicillamine (DPA) on a defined chronic proliferative inflammation in a model granuloma was tested in a long-term experiment. A change in collagen metabolism was detected during the three weeks of DPA administration, whereas the proliferation of the fibroblast population remained unaffected. | 580,041 | [
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A fluorescence approach of the determination of translational diffusion coefficients of lipids in phospholipid monolayer at the air-water interface. | In the present work, it is shown that the photobleaching technique as well as experimentation based on fluorescence recovery after bleaching can be extended to monolayers spread at the air-water interface. A mathematical model is derived which allows the determination of translational diffusion coefficients of species ... | 580,084 | [
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Contraceptive efficacy determination by postcoital testing. | A new vaginal contraceptive method that offers the ease of use with none of the potentially harmful physiologic effects of hormonal contraception was subjected to direct in vivo tests of its efficacy in immobilizing spermatozoa and preventing their entry into the cervical canal. The new contraceptive, a small avoid onl... | 580,086 | [
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0.06542946,
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0.2782775,
0.24200... |
Rationalisation and modification of a germ-free isolator design. | A modified design of polyvinyl chloride isolator, suitable for small laboratory animals utilises room space more effectively than previous models and is particularly useful where accommodation is restricted. The standard attachments and ancillary equipment used with other flexible isolators are compatible with the modi... | 580,102 | [
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0.00726888... |
[A case of malignant lymphoma (lymphosarcomatous type) of the brain (author's transl)]. | A relatively rare case of malignant lymphoma of the brain was reported. A 64-year-old male was admitted to our hospital, October 2, 1976, complaining of right hemiparesis and expressive aphasia. Neurological and radiological examinations revealed a huge space-occupying lesion in the left frontoparietal region. An exter... | 580,109 | [
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0.120990... |
Iodoamino acid composition of poorly iodinated human thyroglobulin fractionated by isopycnic centrifugation. | The distribution of iodotyrosines and iodothyroinines has been studied in poorly iodinated 19 S thyroglobulins isolated by sucrose gradient centrifugation from five human thyroid tissue. The 19 S thyroglobulins have been fractionated by isopycnic centrifugation and 34.5% rubidium chloride gradient. The distribution of ... | 580,134 | [
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... |
Kininase inhibition by glucagon. | In vitro glucagon (1-100 microgram/ml) has been shown to inhibit the degradation of bradykinin by kininases present in kidney microsomes and erythrocytes. Glucagon was less active on kininases present in plasma and was inactive on purified pancreatic carboxypeptidase B. In conscious dogs the intravenous infusion of glu... | 580,144 | [
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0.1020872,
0.1280923... |
Serum-testosterone during oral administration of testosterone in hypogonadal men and transsexual women. | Testosterone tablets of crystal size 2-5 micrometer were administered orally for 10 dags to 3 human subjects with low endogenous serum testosterone (se-T) levels. Fifty mg testosterone increased se-T slightly, while one daily dose of 200 mg maintained the se-T level within normal range for men for more than 12h. No cum... | 580,151 | [
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0.007507392,
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0.1196407,
0.601662,
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... |
The practice of infant feeding among Asian immigrants. | Nutritional problems are very common in infants and young children of Asian immigrants; most arise as a result of inadequate weaning. An Asian infant should be weaned onto a diet which takes into consideration his parents' religious and cultural customs which affect diets. | 580,173 | [
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0.07639194,
-0.019... |
Relationship between tubal function, craniofacial morphology and disorder of deglutition. | 26 children without hearing impairment have been examined by otolaryngologists and orthodontists. According to the tubal function test in a pressure chamber they were classifed into a group with good and poor tubal function. The E.N.T. examination was unconclusive for a possible relationship between rhinological findin... | 580,174 | [
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0.3042895,
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0.2482495,
-0.03628173,
0.0517... |
[Studies on chemical structure and analgetic activity of phenyl substituted aminomethylcyclohexanoles (author's transl)]. | Phenyl substituted aminomethylcycloalkanole derivatives were synthetized and tested for analgetic activity. Substances with a high ratio between acute toxicity and analgetic efficacy were selected for further investigations. Structure-activity relationships of this group were evaluated and compared with those of morphi... | 580,207 | [
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0.5133597,
0.0585505,
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0.03124138,
-0... |
[Algo-pupillometric investigation of the analgesic effect of tramadol (author's transl)]. | 1. The analgesic efficacy of 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (tramadol; Tramal) (75 and 100 mg) was investigated in 22 young, healthy volunteers by means of an algo-pupillometric method. 2. Tramadal itself causes a slight miosis which becomes statistically significant only 3 h after administ... | 580,212 | [
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0.3051239,
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0.05393557,
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... |
Rampant dental caries in the treatment of depression. | Dental Caries are an uncommon, but significant side effect of the tricyclic antidepressants and other anticholinergic psychoactive drugs. The authors trace the etiological aspects of this syndrome including the effects of depression and antidepressant medication on salivary properties. A typical clinical presentation o... | 580,266 | [
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[Investigation of the relationship of the mucilaginous substances of linseed to genotype and source (author's transl)]. | 1. The content of mucilaginous substances, respectively the capacity to swell is primarily a characteristic specific for the variety. 2. Ecologically very different growth locations also have a marked influence, so that appreciable quality differences depending on origin mayorise. 3. From the positive correlation betwe... | 580,325 | [
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Cloxacillin distribution in the rabbit eye after intravenous injection. | Distribution of isotopically labelled and intravenously injected cloxacillin was studied in rabbit eye. The antibiotic concentration determined by liquid scintillation counting proved to be a reliable measure of the total antibiotic concentration when controlled by microbiological assay. In the rabbit eye after an intr... | 580,330 | [
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A note on the pseudo-exfoliation fibrils. | Both transmission (TEM) and scanning electron microscopy (SEM) demonstrate that typical fibrils are the dominant feature of the pseudo-exfoliation (PE) material. The purpose of this work has been to examine whether the TEM and the SEM fibrils are identical, and to determine to which extent the morphology of the PE mate... | 580,331 | [
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Accuracy of evoked potential refractometry using bar gratings. | We recorded cortical potentials evoked by phase-alternating square-wave gratings. Significant effects of varying the refractive power of the eye are obtained only at 5 cycles/degree (cy/deg) and above. The extrapolation to zero amplitude of the evoked response as a function of spatial frequency predicts the psychophysi... | 580,337 | [
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In vivo inhibition of prostaglandin synthesis in rabbit kidney by non-steroidal anti-inflammatory drugs. | To define dose- and time-response properties for in vivo inhibition of renal prostaglandin (PG) synthesis, aspirin, diclofenac sodium, indomethacin and d-naproxen were injected intravenously in different doses to unanaesthetized rabbits. After 30 min. the animals were killed and the post mortem accumulation of PGE2 and... | 580,346 | [
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... |
HLA antigens in autoimmune thyroid diseases. | HLA antigens were determined in 85 unrelated Japanese patients with Graves' disease and 56 patients with Hashimoto's thyroiditis, with the use of the microcytotoxicity test. HLA-Bw35 was found in 36.4% of 85 patients with Graves' disease compared with 13.3% of 150 normal control subjects. This difference in antigen fre... | 580,355 | [
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0.2897367,
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Indirect atomic absorption analysis of ethambutol. | In the presence of cupric ions and sodium hydroxide, ethambutol forms a chelate compound which can be extracted with ethyl-methyl ketone. The amount of ethambutol-copper complex was determined by measuring the copper by Atomic Absorption Spectroscopy (AAS) in the ethylmethyl ketone extract. When this method was applied... | 580,386 | [
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[Metabolic degradation of clonidine (author's transl)]. | From the urine of dogs treated with 14C-clonidine (Catapres) 6 radioactive substances were isolated and their chemical structures identified. The presence of unchanged clonidine, p-hydroxy-clonidine, and dichlorophenylguanidine was confirmed and three new metabolites were detected: 1-(2,6-dichloro-4-hydroxyphenyl)-guan... | 580,388 | [
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... |
Biological properties and clinical application of propolis. X. Preliminary pharmacological evaluation of ethanol extract of propolis (EEP). | A study consisting of an examination of the acute toxicity of ethanol extract of propolis (EEP) in mice, its effect on spontaneous movement in mice and rats, its analgesic properties and its influence on body temperature in mice was conducted. Also examined was the activity of EEP on animals under the influence of narc... | 580,395 | [
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Urinary tract infection in young women, with special reference to Staphylococcus saprophyticus. | Acute urinary tract infections in young women attending a clinic for sexually transmitted diseases were caused by the same bacteria, in the same proportions, as those that caused infections in women students. Staphylococcus saprophyticus biotype 3 (formerly called Micrococcus subgroup 3) was the commonest organism afte... | 580,432 | [
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Relationship between lymphocyte emigration and vascular endothelium in chronic inflammation. | Small blood vessels within areas of chronic inflammation which contain large numbers of lymphocytes develop unusually thick walls. Combined histological and electron microscope study shows that the thickening is due to hypertrophy of endothelial cells which come to resemble the endothelium of post-capillary venules in ... | 580,448 | [
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... |
[Value of manometry in establishing the developmental stage of portal hypertension and the effectiveness of therapeutic portacaval shunt]. | A total of 105 patients have been studied, operated for portal hypertension, that underwent porto-manometric investigations by various methods, before and during surgery. The study was aimed at establishing indications that can be provided by portal manometry on the evolutive stage of portal hypertension. Correlations ... | 580,462 | [
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Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases. | The medical records of 118 cases who met laboratory criteria of DIC were studied. The most frequent etiologies were: Generalized infection (39.8%), trauma (16.9%), malignancy (6.8%) and surgical cases (6.8%). The main clinical manifestations which appeared to be related solely to DIC were (in a decreasing order of freq... | 580,488 | [
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Studies of fibrinogen metabolism in healthy and hypertensive female subjects with the use of autologous I-125-fibrinogen. | 10 healthy female subjects and 15 female patients with essential hypertension were studied with respect to fibrinogen metabolism in a steady state. Autologous I-125-labeled fibrinogen (I-125-fibrinogen) was used as a tracer. Comparison of the results showed that plasma volume, t1/2 of plasma I-125-fibrinogen and fracti... | 580,505 | [
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... |
The time course change after castration in short-loop negative feedback control of LH by HCG in women. | The time course of change in the suppressive effect of human chorionic gonadotrophin (HCG) on luteinizing hormone (LH) and/or LH-beta following castration was studied by a specific LH-beta radioimmunoassay. At 14-50 days after castration 8 women were given 10 000 IU of HCG in a single intramuscular injection (group 1),... | 580,527 | [
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0.04794245... |
Graves' hyperthyroidism. Spontaneous occurrence after autoimmune hypothyroidism with persistent infiltrative ophthalmopathy. | The clinical course of a 39-year-old woman who exhibited uncommon features of autoimmune thyroid disease was followed. The patient's thyroid status changed from hypothyroid to hyperthyroid spontaneously. She also had severe infiltrative ophthalmopathy when she was hypothyroid. The unusual sequence of her condition rais... | 580,553 | [
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0.3625777,
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T4-thyrotoxicosis. | A 41-year-old man had thyrotoxicosis, diffuse goiter, exophthalmos, high titer of antithyroglobulin antibodies but undetectable long-acting thyroid stimulator. Initially, he had both elevated serum thyroxine (T4) and reverse triiodothyronine (rT3) levels, but normal serum triiodothyronine (T3) and free triiodothyronine... | 580,554 | [
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Mammary and other tumors as a response to radiation and multiple stresses. | Parabiosis of paired NEDH rats and subsequent irradiation of one produced multiple stresses, particularly altered hormonal milieu. Benign mammary tumors developed in 8.6% of the control pairs, 12.7% of the shielded partners, and 19.7% of the irradiated rats. Mammary cancers developed in 5% of control pairs, 14.2% of th... | 580,557 | [
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Parathyroid adenoma in submucosa of esophagus. | We recently excised and examined a parathyroid adenoma that was located in the submucosa of the esophagus. It was discovered when an elevated calcium level was found on a screening chemistry profile. Subsequently, the patient was found to have renal stones. At operation two other small parathyroid glands were identifie... | 580,560 | [
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0.4594629,
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Congenital cystic adenomatoid malformation of the lung. | Ultrastructural study of a congenital cystic adenomatoid malformation of the lung revealed a persistence of type 2 pneumocytes lining the alveolar and gland-like spaces. The larger cystic areas were lined by normal bronchiolar-type epithelium and were surrounded by a few smooth muscle cells. The interstitium contained ... | 580,562 | [
-0.06016299,
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0.4209215,
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[Tympanoplasty with human dura mater preserved in cialit (author's transl)]. | In 26 cases allogenetic human dura mater, conserved in CialitTM 1:5000, was used to close perforations of the eardrum instead of commonly used autogenetic fascia of the temporal muscle. In preceding animal studies, it had been found that "Cialit dura" acts as guideline and stimulates the development of new host connect... | 580,571 | [
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0.1731812,
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0.2712017,
0.05147265,
... |
[Metabolism of meproscillarin in man (author's transl)]. | The investigations on the metabolism of 14-Hydroxy-3beta-[(4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin, Clift) were performed in 5 healthy test persons as well as in 4 patients with biliary fistula, applying a single oral dose of 0.5 mg of 3H-meproscillarin. The elimination ha... | 580,585 | [
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0.09867092,
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0.05092788,
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0.2432813,
0.4439743,
0.2798789,
0.1027604,
0.0... |
[The influence of meproscillarin on human left ventricular function (author's transl)]. | Left ventricular (LV) function was assessed by echocardiography in 11 cardiac patients before and after treatment with 14-hydroxy-3beta-[(4-O-methyl-alpha-L-rhamnopyranosyl)-oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin, Clift). This drug was given during 7 days in a dose of 4 X 0.25 mg/d. During a placebo period... | 580,589 | [
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... |
Temporal and spatial patterns of the synthesis of tissue-specific polypeptides in the preimplantation mouse embryo. | Mouse embryos at different morphological stages in the transition from morula to blastocyst were analysed for the qualitative pattern of their polypeptide synthesis. The first appearance of the individual species of polypeptides specific to trophectoderm or ICM occurred progressively over this developmental period. Pop... | 580,617 | [
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0.1533093,
0.2783014,
0.2457652,
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... |
[Lymphoblastic lymphosarcoma of the stomach (author's transl)]. | A case of primary lymphoblastic lymphosarcoma of the stomach, concerning a 15 year old boy, is described. The problematic of such cases is discussed in the light of the respective literature together with the own observation. Diagnostic, therapy and course of the case are reported on. It is emphasized that benign pseud... | 580,631 | [
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Current status of intrathecal chemotherapy for human meningeal neoplasms. | Progress in clinical intrathecal chemotherapy has been slow, and a number of new problems have been encountered. The most significant recent developments include the: 1) success of adjunctive intrathecal chemotherapy in the prevention of meningeal leukemia; 2) recognition and characterization of a necrotizing leukoence... | 580,638 | [
-0.09577226,
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0.2543952,
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0.2525003,
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0.0868459,
0.4617374,
0.1092078,
0.2452835,
0... |
[Pulmonary ultrastructural changes in dogs following experimental hemorrhagic shock (author's transl)]. | The authors have studied the ultrastructure of the lung in dogs following experimental hemorrhagic shock. They found intra-alveolar edema, red cells in the alveolar sac, disappearance of the substance of the lamellated osmiophilic bodies and cellular degeneration. Correlation among these alterations and increase of cap... | 580,645 | [
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0.21368,
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-0.2154612,
-0.04684749,
-0.5173512,
0.1122921,
-0.2394436,
0.06946813,
0.6009728,
-0.08300919,
0.1523774,
-0.0282681,
-0.04610989,... |
Simultaneous and specific determination of proxyphylline, theophylline and other xanthine derivatives in serum by high pressure liquid chromatography. | A HPLC-method for rapid, simultaneous and specific determination of proxyphylline, theophylline, glyphylline, theobromine, caffeine and 3-methylxanthine using 8-chlorotheophylline as internal standard is presented. Using 20 microliter deproteinised serum samples for injection, the the detection limits for theophylline ... | 580,676 | [
-0.1463867,
0.0439077,
-0.2841056,
-0.2138419,
0.2878095,
-0.132323,
-0.3040145,
0.1289989,
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-0.216596,
0.2443781,
0.4511504,
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0.1387095,
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-0.05004336,
-0.4944849,
0.414445,
0.2833164,
0.2551172,
-0.1000542,
0.0... |
Myocardial pharmacokinetics of lithium in vitro. | The myocardial pharmacokinetics of ionised lithium were investigated in isolated, intact rabbit hearts, which were retrogradely perfused with a modified Krebs-Henseleit solution containing lithium in a concentration of 5 mM. The rate of myocardial accumulation of lithium as a function of time was indirectly followed at... | 580,677 | [
-0.2335529,
0.0939259,
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-0.1825252,
0.1052048,
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0.09195326,
0.2999186,
0.3818969,
0.1993024,
0.2375341,
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-0.2141579,
0.1725118,
-0.1436911,
0.04779121,
0.3866957,
0.01319056,
0.05052387,
0... |
Acute toxicity of penicillic acid and rubratoxin B in dogs. | The effect of intraperitoneally administered penicillic acid, a mycotoxin produced by several species of Penicillium and Aspergillus, on female dogs of mixed breeding was determined by serum tests, by observation of clinical signs and survival times, and by evaluation of gross and microscopic lesions. Combination studi... | 580,698 | [
-0.0724241,
-0.4208868,
-0.2598383,
0.141721,
0.1129365,
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0.2256518,
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0.04172052,
0.1141553,
0.06387391,
0.02051292,
0.1260366,
0.0984926,
0.662909,
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-0.0673064,
0.5180132,
-0.1239607,
0.1819652,
0.4990933,
0.1390236,
-0.109... |
[Is there a possibility of paraplacental oxygenation of fetal blood? First results of an investigation with fluorocarbon (author's transl)]. | By checking the cardiotropic effect on fetal rabbits we tried to find out weather there is a possibility of paraplacental oxygenation of fetal blood. Amniotic caves of nine fetal rabbits of 28th or 29th day of gestation are perfused with Perfluorobutyltetrahydrofuran (FX 80, 3 M Comp., St. Paul, Minn., USA) continuousl... | 580,705 | [
0.1992165,
0.126455,
-0.1602667,
0.05587008,
0.3554953,
-0.2420063,
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0.01504464,
-0.3236582,
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0.02626039,
0.5398649,
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0.1576091,
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-0.4012122,
0.05113396,
-0.08124841,
0.4647678,
0.05545474,
0.3991986,
-0.2653044,
... |
Experimental myositis ossificans: cartilage and bone formation in muscle in response to a diffusible bone matrix-derived morphogen. | Bone matrix gelatin, prepared by chemical extraction of soluble noncollagenous proteins, was half digested with a chromatographically purified collagenase. The residue was placed on one side and autologous muscle on the other side of cellulose acetate membranes in diffusion chambers and tissue cultures. In this avascul... | 580,725 | [
-0.3938949,
-0.1777618,
-0.06672676,
0.008281034,
-0.1191152,
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-0.2196304,
0.1038412,
0.2974952,
-0.02764058,
-0.1034317,
-0.2409469,
0.1255027,
0.01291572,
-0.4581749,
0.103537,
-0.338806,
-0.1675633,
-0.1204725,
0.2319307,
0.3690678,
0.06646499,
-0.1694183,
... |
Congophilic angiopathy and cerebral hemorrhage. | All the cases of spontaneous intracerebral hemorrhage that were autopsied between 1965 and 1976 at at Kuakini Hospital, Hawaii, were analyzed to determine the frequency of coexistent cerebral congophilic angiopathy. Seven of 75 cases (9.3%) were confirmed to have deposition of amyloid in the intracerebral vessels by me... | 580,726 | [
0.1063627,
0.09419692,
-0.0372024,
-0.01684144,
0.07093997,
-0.1568,
-0.1007744,
-0.1813997,
0.4279388,
0.09670573,
-0.007317483,
-0.1351235,
-0.1280358,
-0.293545,
0.06891005,
-0.1220036,
-0.1788212,
-0.0385461,
0.2985244,
-0.2665037,
-0.1191391,
-0.0005356836,
-0.050705... |
Selective cytotoxic actions of aspirin on parietal cells: a principal factor in the early stages of aspirin-induced gastric damage. | Electronmicroscopic observations are reported on the effects of orally administered aspirin on the rat gastric mucosa to establish the cytotoxic events that occur during the early stages of the development of gastric damage induced by this drug. The results show that aspirin, apart from damaging superficial mucous cell... | 580,735 | [
-0.1752384,
-0.185511,
0.05168835,
-0.1623244,
0.3205174,
0.07037165,
0.03421706,
0.05829133,
0.3060626,
0.1979326,
-0.09176517,
0.05129992,
-0.258954,
-0.2365731,
-0.4151255,
0.04624087,
-0.1679126,
0.113951,
0.2213659,
0.6149771,
0.3928229,
0.2234982,
-0.01461396,
-0.... |
Cutaneous manifestations of thyroid disease. | Of all the endocrinopathies that may have cutaneous findings, thyroid disease is probably the one most likely to be seen by the practicing physician since the skin readily reflects the functional capacity of the thyroid gland. Cutaneous findings may be the only clue to otherwise silent thyroid disease. Skin changes may... | 580,778 | [
-0.04025473,
-0.3077779,
0.004073182,
-0.3478484,
0.1031364,
-0.2119624,
-0.1207378,
-0.0582319,
-0.07328138,
0.09395041,
0.228029,
0.2079633,
0.1030347,
0.007950034,
-0.1870281,
0.005904115,
-0.3121538,
-0.0267324,
0.1865428,
0.02559953,
0.2171926,
0.1786379,
-0.1585253,... |
Computed tomography in syringomyelia and the associated Arnold-Chiari type I malformation. | A total of 20 patients with an Arnold-Chiari Type I malformation, i.e. without skeletal abnormality and associated with a syringomyelic syndrome, were studied using the EMI Whole Body Scanner CT5000. Two groups were considered: (i) a retrospective series of 12 patients without intrathecal water soluble contrast media a... | 580,796 | [
-0.249674,
0.4305097,
0.2771427,
-0.2266232,
0.1990162,
-0.1636811,
-0.4410654,
-0.5641801,
-0.005635468,
0.2072946,
0.2300416,
0.08213636,
-0.1890589,
-0.0865627,
0.08781867,
-0.1266103,
-0.4585207,
0.520673,
-0.6129707,
-0.02148357,
-0.001631733,
0.1821291,
0.1011096,
... |
Altered metabolism of phospholipids in the lung of rats with peritonitis. | Pulmonary alterations after shock and sepsis, described clinically as shock lung or adult respiratory distress syndrome, are of great importance in intensive care. Pathogenetically an alteration of the surfactant system of the lung is often discussed. Since phospholipids are constituents of lung surfactants, phospholip... | 580,812 | [
0.1424786,
0.1670382,
-0.1080584,
-0.137731,
0.117062,
0.03499449,
0.02664372,
-0.09566372,
-0.04872678,
-0.02780551,
-0.02271535,
-0.460747,
-0.05474717,
0.3829121,
-0.2817435,
-0.07396834,
-0.1854367,
0.0165501,
0.07468191,
0.4439149,
-0.1219689,
0.3595818,
-0.1125925,
... |
Effect of serum albumin on dynamic force-area curve of dipalmitoyl lecithin. | In line with previous findings at 25 degrees C, solutions of serum albumin in the subphase stabilized the surface activity of DPL spread films at 25 degrees C as well as 37 degrees C. In contrast, films adsorbed from mixtures of DPL and albumin exhibitied a marked inhibitory action of the albumin on DPL activity. The i... | 580,813 | [
0.0148599,
-0.2966418,
-0.2081873,
-0.3798756,
0.07578275,
-0.07096407,
-0.1289601,
-0.142237,
0.006562106,
0.02781272,
-0.1050112,
0.05802932,
-0.03421999,
0.00177414,
-0.3851427,
-0.1081787,
-0.4759105,
-0.009577852,
-0.123359,
0.4125542,
0.06573011,
0.09276981,
-0.1962... |
The stability of standards for radioimmunoassay of human TSH: research standard A and the international reference preparation initially 68/38. | The stability of the International Reference Preparation of human TSH for immunoassay (previously distributed in ampoules coded 68/38) and of Research Standard A for HTSH has been examined by radioimmunoassay of accelerated degradation samples (stored as the dry ampouled preparations). Potency estimates on degradation ... | 580,830 | [
-0.2259025,
-0.136722,
-0.05483558,
-0.3393551,
-0.05742813,
-0.06226542,
-0.4062914,
0.31756,
0.1255864,
0.0446871,
0.4413435,
0.196936,
-0.02313675,
-0.08072566,
-0.09367389,
-0.2630822,
0.01318858,
0.002949012,
-0.2321716,
0.4331036,
0.201225,
0.2580801,
-0.3118787,
... |
HLA antigens in a family with maturity-onset type diabetes mellitus. | In a family with maturity-onset type of diabetes mellitus inherited as a dominant, autosomal trait (MODY), the HLA genotypes were compared with the glucose tolerance and the plasma insulin response to oral glucose. In the members with impaired glucose tolerance, the plasma insulin response was of the insulino-tardic ty... | 580,833 | [
0.01734217,
-0.3110409,
0.005927826,
0.1279571,
0.3229948,
-0.4544677,
-0.2590499,
0.2224115,
0.05634158,
0.2309382,
0.1773168,
0.01775435,
-0.05089739,
0.07696847,
-0.1316465,
-0.405411,
-0.1652175,
-0.1868186,
0.07514691,
0.007983623,
0.3247763,
0.1199476,
-0.08083037,
... |
1,25-dihydroxycholecalciferol in hypophosphataemic osteomalacia presenting in adults. | The effects of exogenous 1,25-dihydroxycholecalciferol (1,25(OH)2D3) in two adults with late-onset hypophosphataemic osteomalacia were studied. In the presence of elevated 25-hydroxyvitamin D levels 1,25OH)2D3 improved intestinal 47Ca absorption and increased urinary calcium, phosphate and hydroxyproline excretion. Hyp... | 580,838 | [
-0.2011801,
-0.2202836,
-0.1282572,
-0.1327452,
0.2107103,
-0.3242231,
-0.06542168,
0.1948276,
0.05343507,
0.01769596,
0.4900878,
0.4890043,
0.03829724,
-0.3905979,
-0.6032786,
-0.08452402,
-0.3809825,
0.03439943,
-0.1811489,
0.07068344,
0.001119256,
0.5143947,
-0.2851578... |
Ocular hypertension. II. A carbonic anhydrase inhibitor test for early detection of glaucoma. | The intraocular pressure before and three h after oral administration of a carbonic anhydrase inhibitor was measured in one normotensive, one hypertensive as well as two glaucoma groups. The ratio between the outflow pressure after and before this treatment was estimated. The percentage outflow pressure was found to be... | 580,840 | [
-0.2296057,
0.07395131,
-0.4868852,
-0.1160804,
0.1823505,
-0.1048729,
-0.1080447,
0.1275872,
0.2948468,
-0.327444,
0.09885232,
0.203698,
0.07198799,
-0.3671779,
-0.2687618,
0.04142031,
-0.1012384,
0.4455121,
-0.2864569,
0.1482798,
0.005263013,
0.3707074,
0.08410212,
0.... |
Effects of guanadrel on patients with thyrotoxicosis. | Eleven patients with Graves' disease were treated with guanadrel sulfate and observed for changes in neuromuscular and cardiovascular manifestations. No notable changes in pulse rate or muscle strength were detected in either these patients during a three-day pretreatment period or in five control patients with Graves'... | 580,863 | [
-0.1231082,
-0.1239343,
-0.2223733,
-0.3265351,
-0.002669723,
-0.251709,
-0.07211065,
-0.2875985,
-0.1659559,
0.0335574,
0.0007501529,
0.3480533,
0.07403539,
-0.1642558,
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0.1213152,
-0.3351692,
-0.02378093,
-0.04514603,
0.1979849,
0.1382197,
-0.04768975,
0.0304... |
Myocardial involvement in Rocky Mountain spotted fever. | Rocky Mountain spotted fever (RMSF), an acute febrile exanthematous illness caused by Rickettsia rickettsii and transmitted by ticks, is endemic in the southern Atlantic states. This report is based on the clinical and pathological findings of myocardial involvement in 16 children who died with severe RMSF. All 16 chil... | 580,868 | [
-0.2332897,
-0.003711257,
-0.05474072,
-0.233232,
-0.07527749,
0.04556962,
-0.1749937,
0.01046483,
-0.1135375,
-0.1138314,
0.392114,
0.1475316,
-0.05272967,
0.1051094,
-0.1791703,
-0.3149777,
-0.3225936,
-0.04108128,
0.07923979,
-0.1388178,
0.2724396,
0.17513,
-0.1636522,... |
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