title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Affinity labelling of human transcortin. | The binding site of transcortin has been studied by using bromoacetyltestosterone and bromoacetylated derivatives of progesterone which were monohydroxylated at different positions of the steroid nucleus. Specificity of affinity labelling was demonstrated by the displad cortisol analog was added to a [3H]cortisol-trans... | 588,587 | [
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Purification of C-reactive protein on DEAE-cellulose by a simple two-step procedure utilizing the calcium-dependency of the protein. | A simple procedure for isolating C-reactive protein is presented. The method consists of two chromatographic separations on diethylaminoethyl (DEAE)-cellulose columns and utilized the difference between the binding of C-reactive protein to DEAE in the presence and absence of calcium. Electrophoretically pure C-reactive... | 588,590 | [
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Regulation of nitrogen fixation in Rhizobium spp. Isolation of mutants of Rhizobium trifolii which induce nitrogenase activity. | This communication describes the isolation and characterization of mutants of Rhizobium trifolii which can induce nitrogenase activity in defined liquid medium. Two procedures were used for the isolation of these mutants from R. trifolii strain DT-6: (1) following chemical mutagenesis, slow growing mutants were selecte... | 588,592 | [
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[The substrate specificity of trypsin. The interrelationship between the structure and reactivity for quasi-substrates, derivatives of O-alkylmethylphosphonic acid and carboxylic acids]. | The kinetics of trypsin phosphorylation by thioesters of O-n-alkylmethylphosphonic acids, and reactivation of corresponding phosphoryl enzymes as well as kinetics of trypsin-catalyzed hydrolysis of p-nitrophenylcarboxylates have been studied. The rate constants for phosphorylation and dephosphorylation of trypsin depen... | 588,630 | [
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[Properties of alpha-chymotrypsin enclosed into polycarbonate microcapsules. Estimation of the diffusion effect]. | The conditions for the microencapsulation of alpha-chymotrypsin into semi-permeable polycarbonate membranes are selected. The diameter of the microcapsules is 100-150 microns. The microencapsulation can be carried out at any value of pH. The effect of the diffusion in the hydrolysis of some esters by microcapsulated al... | 588,635 | [
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Creatine kinase activity in suicide by burning. | In the course of a systematic study of serum enzymes activities from muscular tissues, applied to fifty six burnt patients taken at random, the authors have observed a significant and isolated raised of serum CPK in six burnt people when they were admitted to hospital. There were no known causes of raised CPK essential... | 588,663 | [
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Study of carboxyl groups on the human blood platelet membrane. | The authors have studied the whole carboxyl groups of the platelet membrane using liquid phase electrophoresis and an initial step of activation of the acid group by a water soluble carbodiimide (ethyl-l-diméthyl-aminopropyl-3-carbodiimide), followed by the action of a nucleophilic molecule. The calculation based on th... | 588,668 | [
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Pharmacologic modification of therapeutic measures used in managing the neurogenic bladder. | In the past 2 years, no supravesical urinary diversions have been done for myelodysplasia at St. Louis University Medical Center. Twenty-six patients with neuropathic bladders have been managed by intermittent catheterization and mechanical devices. The addition of anticholinergic and alpha-adrenergic agents to the the... | 588,676 | [
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Technical aspects of megaureter repair. | Megaureter is a correctable problem. Repair should be considered in appropriate cases; it is demanding surgery, however, which should not be attempted on an occasional basis. Results can be satisfactory in more than 90% of cases if certain technical points are followed, as enumerated in Table 2. | 588,690 | [
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[Energy potential of the cerebral cortex in the pre-agonal and post-resuscitation period after acute blood loss]. | In experiments on dogs it was revealed that during the preagonal period, after a four-hour hypovolemic hypotension, the content of ATP was reduced in the gray matter of the brain by 38 percent, and of ADP and AMP increased by 121 percent and 875 percent, respectively. Reflecting these shifts the energy charge potential... | 588,731 | [
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[Cytostatic effect of cyclophosphane on esophageal tumors and epithelium of mice]. | Investigation of cytostatic activity of cyclophosphamide in sarcoma 37 and esophagus epithelium in albino mice with respect to the diurnal rhythm of mitotic activity and the number of labeled nuclei was performed. Apparently the tumour cells in the G1-phase and at the beginning of the S-phase of the mitotic cycle were ... | 588,738 | [
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[Scanning electron microscope study of the secondary palate during embryonic formation in the rat]. | Normal fetuses 14 to 17 days old were obtained from female Wistar rats. The palates have been studied, after dissection, by scanning electron microscopy. Palatal closure is achieved, in the median and posterior region, by the elevation of the lateral palatine processus from a ventro-medial to a horizontal position; imm... | 588,759 | [
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Effect of dieldrin on the stability of lysosomes in the rat liver. | The effect of dieldrin on the bound and free activity of cathepsin, acid ribonuclease, acid phosphatase and aryl sulphatase has been investigated. Administration of dieldrin increased the activity of free cathepsin, acid ribonuclease, and acid phosphatase in rat liver whereas it did not affect the activity of aryl sulp... | 588,771 | [
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Transient changes in plasma digoxin concentration and the development of cardiotoxicity. | 1. Eight dogs were given two infusions of digoxin 0.1 mg/kg, one over 9 min and the other one over 90 min in a randomized sequence, allowing at least 12 days between each experiment. 2. Digoxin plasma profiles reflected the rate of digoxin infusion, the peak concentration of drug attained at the end of each infusion be... | 588,806 | [
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The effect of uptake by adrenergic nerve terminals on the sensitivity of arterial vessels to topically applied noradrenaline. | 1. Direct observations were made of the rat mesenteric vasculature in vivo. They showed a gradual increase in the sensitivity to topically applied noradrenaline from the larger arteries to the precapillary arterioles which was paralleled by a gradual decrease in the density of the adrenergic innervation. 2. Both cocain... | 588,808 | [
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Do newspaper reports of coroners' inquests incite people to commit suicide? | A statistical association has been found between reports of suicide inquests in a local paper and the subsequent suicide of men under 45 years. | 588,871 | [
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Affiliation before and after child delivery as a function of repression-sensitization. | A group of 177 women were asked, before and after child delivery, to state their preference for being alone or with other women. They were also asked to rank their level of anxiety. After delivery they filled out the Repression-Sensitization Scale of Byrne, Barry & Nelson (1963). Results show sensitizers to be more... | 588,887 | [
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The left aortic arch and right descending aorta. | Three patients with a left arch and a right descending aorta are described, all presenting in infancy. In one patient the abnormality was acquired, yet the radiological appearances were very similar. The place of the barium swallow in the diagnosis is discussed, and it is concluded that aortography is required for a de... | 588,898 | [
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Interaction of hyperthermia and radiation: the survival surface. | The interaction of hyperthermia and radiation on cell survival is illustrated by the increase in sensitivity to radiation caused by hyperthermia and the increase in sensitivity to hyperthermia caused by radiation. A method of expressing the total response to a combination of these two agents by means of a survival surf... | 588,919 | [
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The anatomy of the urethral stricture. | A post-mortem study of the urethral anatomy following gonorrhoea is presented. The different specimens examined demonstrated lesions ranging from microscopic submucosal scars to fully developed urethral strictures. In every specimen extensive squamous metaplasia of the surface epithelium was present. It is postulated t... | 588,963 | [
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Plasma catecholamine concentrations during operation. | Plasma catecholamines have been measured before, during and after operation in 40 patients undergoing elective major abdominal surgery and in 12 patients during open heart surgery. Plasma concentrations did not increase during abdominal surgery and showed only small increases during cardiopulmonary bypass. It appears t... | 588,972 | [
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A case of myasthenia gravis with thyrotoxicosis treated by combined subtotal thyroidectomy and total thymectomy. | Thyrotoxicosis occurring in conjunction with myasthenia gravis is rare. The usual treatment consists of medical control of the thyrotoxicosis, then thymectomy and later subtotal thyroidectomy. The case reported here concerns a 19-year-old girl who had surgical treatment for both lesions on the same occasion. With prope... | 588,979 | [
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Association of serum lipids and obesity with cardiovascular mortality. | Serum lipid concentrations, relative body weight, and smoking habits were assessed in a cohort of 1648 middle-aged Finnish men who were subsequently followed for seven years. Multivariate analysis showed that serum triglyceride and cholesterol concentrations and smoking were all independently associated with cardiovasc... | 589,076 | [
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Diet and heart: a postscript. | During 1956-66, 337 healthy middle-aged men in London and south-east England participated in a seven-day individual weighed dietary survey. By the end of 1976, 45 of them had developed clinical coronary heart disease (CHD) which showed two main relationships with diet. Men with a high energy intake had a lower rate of ... | 589,165 | [
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Management of airway complications of burns in children. | Children who have been exposed to smoke in a confined space or who have soot or burns, however minimal, on the face should be admitted to hospital. Respiratory distress may be delayed, but if it is progressive the patient should be curarised, intubated, and mechanically ventilated. Unless ventilation continues for 48 h... | 589,269 | [
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Acute leukaemia after busulphan. | During a double-blind study of two years' cytotoxic chemotherapy with busulphan or cyclophosphamide in patients who had had resection of carcinoma of the bronchus the long-term effects of these two drugs were also studied. Four of the 243 patients treated with busulphan developed leukaemia compared with none of the 234... | 589,308 | [
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Long-term prognosis of duodenal ulcer: follow-up study and survey of doctors' estimates. | In 1976 we reviewed a randomly selected cohort of 227 patients with duodenal ulcer first diagnosed in 1963. The cohort comprised cases diagnosed in both hospitals and general practice. Fifty patients had died, 12 had emigrated, and 154 (93%) of the remaining patients were interviewed. Fifty-seven medically treated pati... | 589,350 | [
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Recent micturition does not affect the detection of urethral gonorrhoea. | In 202 men with urethral gonorrhoea (176 symptomatic and 26 asymptomatic) who had modified Thayer-Martin cultures taken before and within five minutes after micturition there was complete agreement between results of the two cultures. Micturition did, however, temporarily eliminate the discharge in 100 (56.8%) and make... | 589,425 | [
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Stimulation and maintenance by nerve growth factor of phenylethanolamine-N-methyltransferase in superior cervical ganglia of adult rats. | Treatment of newborn rats with nerve growth factor (NGF) results in a striking increase in phenylethanolamine-N-methyltransferase (PNMT) in the superior cervical ganglia. Between one and three weeks of age there is normally a 10-fold decrease in PNMT activity in ganglia of infant rats. NGF treatment maintains the PNMT ... | 589,478 | [
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Synaptosomal plasma membrane glycoproteins. II. Isolation of fucosyl-glycoproteins by affinity chromatography on the Ulex europeus lectin specific for L-fucose. | After solubilization in sodium dodecyl sulphate, almost 90% of synaptosomal plasma membrane glycoproteins were separated from the bulk of synaptosomal plasma membrane proteins by sequential affinity chromatography on two immobilized lectins: concanavalin A and the Ulex europeus lectin specific for L-fucose. Four fracti... | 589,479 | [
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Structural rearrangements of chromosomes in the domestic chicken: experimental production by X-irradiation of spermatozoa. | In order to produce chicks heterozygous for structural aberrations of chromosomes, 67 hens were inseminated with semen that had been exposed to 1200 R of X-rays. A sample of 204 chicks was hatched and survived. Among these, 18 (8.9%) contained rearrangements comprising 19 translocations and one pericentric inversion. A... | 589,515 | [
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Utilization of an evening/night hospital: first two years of operation. | This study examined the utilization of an integrated evening/night hospital by 234 psychiatric patients referred to the hospital during its first two years of operation. Neither age, sex, marital status, referral source or diagnosis were related to utilization. However, patients whose previous treatment involved tradit... | 589,548 | [
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0.003386... |
On being therapeutic. | Psychotherapy is both an art and a science. The art deserves as careful study as does the science. In this paper the author puts forward the view that the effectiveness of psychotherapy is dependent to a marked degree upon certain innate characteristics of the therapist: these include his character structure, his perso... | 589,551 | [
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Extended field radiation therapy in Hodgkin's disease: analysis of failures. | A retrospective analysis of 116 primary cases of stage I, II and III-A Hodgkin's disease demonstrated 27 failures, fourteen confirmed by biopsy. Twenty of the 27 (74%) were in lymph node areas only and seven had extranodal extensions. The most frequent site of failure was the hilar nodes and contiguous lung. The majori... | 589,558 | [
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0.06399064,
0.3991725,
0.1739876,
0.113678,
0.05... |
Intralymphatic BCG in the treatment of gynecologic malignancies: a phase I study. | Thirteen patients with a variety of advanced gynecologic malignancies were administered BCG via the dorsal lymphatics of the lower extremity in addition to standard accepted forms of therapy. Prolonged febrile courses, lymphangitis and suppurative adenitis were observed along the lymphatic pathway of the injected lower... | 589,560 | [
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0.4450183,
0.2987567,
0.1631756,... |
Studies on carcinoembryonic antigen levels in patients with adenocarcinoma of the uterus. | Carcinoembryonic antigen was determined before treatment in 101 patients with adenocarcinoma of the uterus. If 2.5 ng/ml is accepted as the upper normal value, 34% of the patients with cancer of the corpus had elevated levels. Only 7% had values exceeding 5 ng/ml. The highest recorded value in endometrial carcinoma was... | 589,561 | [
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0.09151713,
0.3945225,
0.184659,
0.06902345,
0.10... |
Implications of the 99mTc diphosphonate bone scan on treatment of primary breast cancer. | The 99mTc diphosphonate scan is important in the study of primary breast cancer. The short-term prognosis for scan-positive patients is poor. Serial bone scans provide a safe and reliable prognostic index in patients following mastectomy. By correlating the scan with biochemical tumor markers, a matrix of diagnostic te... | 589,595 | [
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0.196074,
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0.1076269,
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Combinations of tetrahydrouridine and cytosine arabinoside in mouse tumors. | Thirteen experimental mouse neoplasms were tested by cytidine (CR)-deaminase and deoxycytidine (dCR)-kinase levels. Four neoplasms, Sarcoma T241, Adenocarcinoma E0771, Lewis lung carcinoma (LL), and Sarcoma 180 Japan (S180J), considered to have high deaminase and sufficient dCR-kinase activities, were tested in vivo fo... | 589,601 | [
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0.4332975,
0.07826978,
0.2771866,
0.0112794,
0... |
Cytochemical study of the lamellar bodies in the swimbladder of the toadfish Opsanus tau L. | The columnar epithelial cells of the gas gland in the swimbladder of the toadfish, Opsanus tau L., contain lamellar bodies that resemble the lamellar bodies found in epithelial cells of vertebrate lungs. Cytochemical assays indicate that swimbladder lamellar bodies are soluble in chloroform-methanol solution, react wit... | 589,664 | [
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0.2429327,
0.1201146,
0.279837,
0.01609195... |
Correlation between skin tests, inhalation tests and specific IgE in a study of 120 subjects allergic to house dust and Dermatophagoïdes pteronyssinus. | The radioallergosorbent test was compared with currently accepted allergy diagnostic techniques in seventy-four controls and 120 patients with a clinical history of allergy to house dust and Dermatophagoïdes pteronyssinus. The results obtained with D. pteronyssinus allergen extract show a close correlation between the ... | 589,770 | [
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0.1986105,
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0.2535698,
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0.03040849,... |
Immunoglobulin E specific to wheat and rye flour proteins. | We have used the radioallergosorbent test (RAST) to determine IgE antibodies specific to wheat flour proteins in the sera of seven groups of patients. In some cases rye-specific IgE was also determined. Wheat and rye RAST scores showed a good correlation, presumably due to cross-reactions. Among bakers with asthma, pos... | 589,781 | [
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... |
Fungal antigens as a source of sensitization and respiratory disease in Scottish maltworkers. | Mycological and serological studies were carried out as part of a survey of respiratory disease in Scottish maltworkers. 70% of stained sputum smears from 574 workers showed the presence of higher plant cells and/or myclelia, and the spores of common environmental fungi. Penicillium spp. (90%), Rhizopus stolonifer (48%... | 589,785 | [
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... |
Determination of red blood cell superoxide dismutase and glutathione peroxidase in newborns in relation to neonatal hemolysis. | Superoxide dismutase and glutathione peroxidase activities have been determined in newborns. Their mean values are approximately the same as in normal adults. In some cases a low content of superoxide dismutase and/or a high (superoxide dismutase/glutathione peroxidase) ratio are associated with hematological symptoms.... | 589,793 | [
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0.371336,
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Sensitivity changes in guinea-pig atria and ileum following subacute administration of dyflos. | 1. Subacute administration of dyflos to guinea-pigs (1.2 mg/kg, s.c., daily for 10 days) led to the development of subsensitivity to carbachol in the ileum but not in the electrically stimulated left atrium. 2. Atria from dyflos-pretreated animals became supersensitive to acetylcholine but the ileum became subsensitive... | 589,870 | [
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The effects of sodium chloride, urea and mannitol on the permeability in vitro fo rat papillary collecting ducts to THO, 14C-urea and 22Na. | 1. The diffusional permeabilities of collecting duct membranes to THO, 14C-urea and 22Na+ have been measured at different concentrations of urea, NaCl and mannitol. 2. In the absence of urea in perfusate and bath or in its presence in low concentrations, the diffusional permeability to urea was 2.0 (s.e.m. = 0.15, n = ... | 589,872 | [
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... |
Thyroid dysfunction following external irradiation to the neck for Hodgkin's disease in childhood. | Thyroid function was studied in 32 patients who had received neck irradiation during childhood for Hodgkin's disease. All except one patient received a dose of 2500-3000 rad over a period of 19-25 days. In 12 patients lymphangiography was performed. Clinically all patients were considered euthyroid. One had a thyroid s... | 589,902 | [
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0.2962922,
0.3893069,
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The two-film barium meal in the exclusion of coeliac disease. | Prospective experience over five years is described in assessing the two-film barium meal as a test for the exclusion of untreated celiac disease in children in order to try to make jejunal biopsy unnecessary. 287 meals were examined in children between 3 months and 10 years of age with a variety of gastro-intestinal s... | 589,918 | [
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0.2490687,
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... |
Sensitivity to isopropyl alcohol. | Positive patch test reactions to isopropyl alcohol in connection with proved allergy to ethyl alcohol have already been published. A case of allergy to isopropyl alcohol with positive reactions to isopropanol (unpurified test material) and negative reactions to ethanol and methanol has also been reported. We report a c... | 589,996 | [
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0.5192845,
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0.399539,
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0.06963781,... |
Sodium lauryl sulfate irritant patch tests: degree of inflammation at various times. | Irritant reactions were induced on the forearms of 10 normal subjects with 10% aqueous sodium lauryl sulfate under patch test occlusion for 24 h. Test sites were observed at 24, 26, 28, 30, 48, 72 and 96 h and the degree of inflammation recorded. Inflammation was most prominent at 28 h and decreased in intensity over t... | 589,998 | [
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0.1146971,
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0.2354223,
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Acute hallucinosis due to clonidine. | A case is reported of a 54-year old man who developed acute hallucinosis while being treated for hypertension with clonidine. The history revealed a similar previous episode which also cleared on discontinuation of the drug. | 590,025 | [
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0.1... |
Complications of ventriculo-peritoneal shunting and a critical comparison of the three-piece and one-piece systems. | This is a report of our experience with ventriculo-peritoneal shunting, the treatment of congenital and secondary hydrocephalus. It includes a detailed listing of all complications and an analysis of the number of complications per patient and per procedure in patients in whom either a three-piece or a one-piece shunt ... | 590,045 | [
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0.1430794,
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[Influence of exogenous collagen on the metabolism of skin wounds in rats]. | Skin wounds of rats were treated by 14C-labeled collagen from guinea pig skin. The main portion of the applied collagen persisted in the wound area. In the neutral salt soluble collagen maximal specific activity was measured on day 4 after treatment, in the citric acid soluble and in the insoluble collagen at later tim... | 590,049 | [
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0.02610868,
0.3433065,
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EEG in benign intracranial hypertension. | A retrospective study of standard EEG's obtained from 26 patients with benign intracranial hypertension was done with particular emphasis on the effect of age on the EEG findings. Abnormal EEG's were found in 10 patients, all were less than 20 years of age. Although no consistent pattern of EEG abnormality could be ide... | 590,056 | [
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0.123827,
0.09369299,
0.0371381... |
[Effect of the preparations amiodarone, pexid and CERM-1978 on sinus rhythm and atrioventricular conduction in unanesthetized dogs]. | The author examined the influence of Amiodarone, Perexiline maliate (Pexid) and the preparation CERM-1978 (Bepiridil) on the sinus rhythm and atrioventriular conduction of trained dogs with preliminary implanted electrodes for electrostimulation of the right atrium under the conditions of chronic experiment. The three ... | 590,177 | [
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0.002910412,
0.1812138,... |
Preprolactin represents the initial product of prolactin mRNA translation. | mRNA isolated from a line of functional rat pituitary tumor cells (GH3) added to a cell-free protein synthesizing system derived from wheat embryo directed the biosynthesis of only one protein which is immunoprecipitated by prolactin antiserum. This protein, 2000--3,000 daltons heavier than prolactin and referred to as... | 590,193 | [
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0.465123,
0.2157455,
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0.... |
Properties of the cytoplasmic progestin-binding protein in the rabbit uterus. | An exchange assay for the measurement of total cytoplasmic progestin binding sites has been developed on rabbit uterine cytosol using the highly potent progestin, R5020 (17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione) labelled to a high specific activity. This compound has several advantages over progesterone: it is ... | 590,197 | [
0.08164672,
0.2043657,
-0.07990365,
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0.01101219,
-0.1041843,
0.01230734,
0.1521949,
0.1045162,
0.2751167,
0.07449425,
-0.1048538,
0.1831977,
0.01882251,
-0.5357685,
-0.1940278,
-0.3202054,
-0.05215573,
0.249969,
0.2850988,
0.4663897,
0.4884534,
0.0399389,
0.0... |
Growth hormone secretion in women with hypothalamic, maternal and simple obesity. Part II. | Dynamic quality of HGH secretion in women with hypothalamic, maternal and simple obesity has been examined by means of the following tests: 1. glucose loading 2. hypoglycaemia following the insulin administration. Comparisons have been made with regard to normal, non-obese women. In all the obese women HGH mobilization... | 590,206 | [
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0.18... |
[Small-angle X-ray-scattering investigation and structural-model study of the fatty-acid synthetase from pig liver (author's transl)]. | The structure of the fatty acid synthetase from pig liver was studied on models based upon structural and functional properties selected from pertinent results available from numerous investigations carried out with fatty acid synthetases from this and other sources. When comparing small-angle X-ray-scattering curves c... | 590,265 | [
0.1258129,
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0.2938832,
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0.4883333,
0.2043701,
0.2254845,
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... |
Aspects of microenvironmental compartmentation. An evaluation of the influence of restricted diffusion, exclusion effects, and enzyme proximity on the overall efficiency of the sequential two-enzyme system malate dehydrogenase--citrate synthase in its soluble and immobilized form. | Soluble bifunctional enzyme aggregates have been prepared by cross-linking the sequential enzymes malate dehydrogenase (EC 1.1.1.37) and citrate synthase (EC 4.1.3.7) using glutaraldehyde. The kinetic behaviour of this two-enzyme system in its aggregated and non-aggregated form was studied both in free solution and imm... | 590,271 | [
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0.177078,
0.04459976,
0.1885647,
0.2764382,
0.407218,
0.08596698,
0.125... |
Persistent post-enteritis diarrhoea. | Clinical, biochemical, and gastroenterological data have been examined im 48 patients in two age groups, one under 12 months of age, the other between 12 and 30 months with persistent post-enteritis diarrhoea. In these patients, the illness consisted of chronic diarrhoea which followed acute enteritis. It brought about... | 590,275 | [
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0.02461728,
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0.3449577,
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0.2782987,
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0.1610857,
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0.1852076,
-0.1741517,
... |
A noninvasive study of the response of ischemic heart to exercise. | The response to exercise during increasing workloads (supine bicycling), was studied in 105 men, of whom 70 had ischemic heart disease and 35 did not, clinically classed into 6 groups. Heart rates, blood pressures and systolic time intervals (STI) were measured in relation to exercise tolerance and capacity. The ischem... | 590,297 | [
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-0.0005446158,
0.03176762,
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0.05413982,
0.2433886,
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0.1694316,
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0.0130958,
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0.3033232,
-0.2165936,
0.402505,
-0.1523224,
0.1994508,
-0.0601106... |
Angina pectoris in presumably healthy middle-aged men. Validation of two questionnaire methods in making the diagnosis of angina pectoris. | In 2014 presumably healthy men aged 40-59 yr the prevalence of previously undiagnosed angina pectoris was assessed by two angina questionnaires: (1) World Health Organization Questionnaire (WHO-Q) and (2) Greater New York Health Insurance Plan Survey Questionnaire (NY-Q). The angina prevalence given by the questionnair... | 590,299 | [
-0.1254326,
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0.4764506,
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-0.2428621,
0.3648473,
0.256995,
-0.1859171,
0.341... |
3H-metaraminol releasing action of mescaline from rat hypothalamus in vitro. | The amine releasing action of mescaline was investigated in rat isolated hypothalamus labeled with 3H-metaraminol. Mescaline had no effect on the uptake of 3H-metaraminol but produced its release in a concentration-related manner. 4 x 10(-4) M mescaline, which produced submaximal effects was used for subsequent experim... | 590,326 | [
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0.09587186,
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0.1831124,
0.319315,
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0.02949007,
-0.... |
Evidence for an inhibitory action of methyldopa on spinal sympathetic reflexes. | The antihypertensive activity of methyldopa is mediated primarily by effects on the central nervous system. A number of centrally acting hypotensive substances has recently been shown to depress spinal pathways and reflexes as well as inhibiting supraspinal areas. The present series of experiments evaluated the potenti... | 590,335 | [
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0.2516333,
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0.06859498,
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0.290118,
0.05328116,
0.2268717,
-0.1592152,
0.08414835,
0.132871... |
An effect of beta-melanocyte stimulating hormone (beta-MSH) on alpha-motoneurones of cat spinal cord. | Actions of beta-MSH and of melatonin on the recovery cycle of single spinal neurones were studied in the decerebrate-spinal cat. beta-MSH facilitated the rate of post-excitation recovery of alpha-motoneurones and some internuncial neurones, and melatonin inhibited the rate of post-excitation recovery. These observation... | 590,341 | [
-0.008004476,
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0.2201293,
-0.04808098,
0.06110624,
0.5113299,
0.3234549,
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0.09957392,
0.0999691,
-0.05635383,
0.1017081,
-0.07658512,
0.01... |
[Fluctuation and distribution of animal room temperature and the temperature in cages (author's transl)]. | The temperature of various positions in an occupied animal room (mice, rats) including inside of cages were measured using a 50 channels thermal data recorder (step time 0.5 sec, 5 min intermittent through 24 hr and continuous) in a summer day. Any short periodical fluctuation of room temperature had practically no inf... | 590,351 | [
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0.1122744,
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-0.09259163,
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0.02011349,
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0.1281441,
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0.1777743,
0.2094257,
-0.02086295,
0.2523448,
-0.07... |
[Simplified methods in sampling and shipping of individual sera from mice and rats for serological checking of infections (author's transl)]. | The usefulness of simplified techniques in sampling of individual mouse and rat sera and their shipping in wet state for serological checking of infections were described. | 590,352 | [
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-0.2194167,
-0.2041927,
-0.2311119,
0.006885102,
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0.05192809,
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-0.1838371,
0.1098406,
0.175734,
0.3593691,
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-0.1952647,
0.3027514,
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-0.1906296,
-0.1041391,... |
Effect of a low dose of vincristine on platelet production in mice. | The effect of a single low dose (0.1 mg/kg) of vincristine (VCR) on platelet production was investigated in C57B1 mice. A parallel increase of circulating platelets and (75Se)-selenomethionine (Se-Met) uptake was observed. The total megakaryocyte count decreased insignificantly 6 hours after VCR injection, followed by ... | 590,406 | [
-0.3970636,
-0.3424731,
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0.2561188,
0.09035969,
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0.09194642,
0.03949835,
0.5936532,
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0.1365842,
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0.005011852,
0.1666505,
0.05861121,
0.7080266,
0.2652338,
0.3920105,
0.1097744,
-... |
The effects of chronic peroxide intake on the peroxide metabolism enzyme activities of rat organs. | In rats receiving a dilute aqueous solution of hydrogen peroxide for a prolonged period, the activity of the peroxide metabolising enzymes, i.e. superoxide dismutase, peroxidase and catalase, is significantly increased in most tissues. | 590,442 | [
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-0.1514239,
-0.4430428,
0.106757,
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0.2121976,
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0.1365153,
0.08581289,
0.1772901,
-0.0354937,
0.4167302,
-0.07739672,
... |
The levels of metallothionein-like proteins in animal tissues. | The level of metallothionein-like proteins was determined in different tissues of 6 animal species. The highest concentrations were found in pig and rat tissues. The organs richest in metallothionein-like proteins included: kidneys (101-305 microgram/g), intestine (127-257 microgram/g) and liver (54-496 microgram/g). | 590,455 | [
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-0.3053863,
-0.1265841,
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0.1289587,
0.03371264,
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0.03061541,
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0.05829081,
0.2087802,
0.01329133,
0.3177679,
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0.08593924,
-0.3560254,
0.0287645,
0.08753303,
0.267716,
0.1587994,
0.1851421,
0.006542046,
... |
Chlorinated benzene induction of hepatic porphyria. | 1,4-Dichlorobenzene and 1,2,4-trichlorobenzene were compared with hexachlorobenzene which is known to cause porphyria. Although hexachlorobenzene administration resulted in a manyfold increase in liver porphyrin levels and urinary excretion of porphyrins, the lesser chlorinated compounds did not do so. | 590,457 | [
-0.264006,
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-0.2244629,
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0.209474,
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0.1648801,
0.1777461,
0.05188922,
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0.4023556,
0.0632374,
0.04650324,
-0.02210861,
0.2816582,
-0.01024453,
... |
Parental focus of attention in a videotape feedback task as a function of hypothesized risk for offspring schizophrenia. | The families of 29 disturbed but nonpsychotic adolescents were observed in a structured task in which they discussed their reactions to viewing themselves interacting on videotape. Measures derived from the Singer-Wynne concenpt of transactional style deviance were applied to the parental behaviors and related to prior... | 590,475 | [
0.02258943,
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0.1666037,
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0.1635328,
0.0002353345,
-0.1617427,
0.08541733,
0.2480787,
-0.1681799,
... |
[Oposite effects of audiogenic stress on the liver and adrenal dehydrogenase of the HMP shunt]. | The effects of audiogenic stress (92 dB at 2000 Hz) on the liver and adrenal levels of glucose-6-phosphate-dehydrogenase (G6-PD) and 6-phosphogluconate-dehydrogenase (6-PGD) were studied in adult male rats. Blood glucose and liver glycogen were also measured. In liver of stressed rats the levels of glycogen, G6-PD and ... | 590,497 | [
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0.02887138,
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0.08616078,
0.03080533,
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0.2336219,
-0.1205282,
0.3867991,
0.06680265,
-0.03314266,
-0.165... |
[Adaptational characteristics of muscle stretch receptors of the dynamic type]. | In cats with deefferented m. triceps, some stretch receptors of the dynamic type were shown to adapt rapidly after stretching of the muscle and keeping it at the new length, whereas other receptors revealed rapid and slow components of the adaptation. The units with different kinds of adaptation coexist in the same mus... | 590,569 | [
-0.1259897,
0.006202962,
0.1385924,
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0.1353332,
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0.118067,
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0.02563942,
0.1702503,
-0.1248824,
0.010983... |
The use of loperamide for treatment of "difficult to manage" chronic diarrhoea in adults. | An open study of loperamide in seven chronic diarrhoea patients who were inadequately controlled by previous anti-diarrhoeal therapy is reported. All patients were well controlled by small amounts of loperamide and most could not eat a normal diet. No side-effect were reported. | 590,602 | [
-0.1639446,
0.1980247,
0.02387611,
0.1356621,
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0.1363055,
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0.06493526,
0.02147019... |
Maprotiline (Ludiomil) in depression: a multicentre assessment of onset of action, efficacy and tolerability. | Although open studies have a built-in bias of optimism the results from this study, made valid by the large numbers of patients involved, support the findings reported with smaller numbers in controlled series of studies showing an early onset of action with maprotiline (Ludiomil). The method used in this study to dete... | 590,608 | [
0.1173434,
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0.1843026,
-0.01092958,
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-0.0839962,
-0.05520516,
0.03475255,
0.3002151,
0.2622954,
-0.4275009,
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0.3973301,
0.08357564,
0.1511607,
0.003167612,
0.07228041,
0.1060292,
... |
Perturbance analysis of nuclear determination in Tetrahymena I: background, rationale, and illustrative example, employing temperature responses. | A model based on comparative considerations, is presented for the nuclear determination of mating type in Tetrahymena thermophila. The model proposes a system of three binary control elements, each capable of stable persistence in one of two states. A general method is proposed for evaluating the model and for assignin... | 590,659 | [
0.08897235,
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0.04363153,
-0.04378738,
0.1220891,
0.3725482,
0.3850708,
0.161632... |
Modification of pigmentation patterns in allophenic mice by the W gene. | Mouse embryos heterozygous at the W locus were combined with embryos which were wild type at this locus but homozygous for albino. The resulting allophenics displayed an unusual pigmentation phenotype consisting of entirely white fur and ruby-coloured eyes. Microscopic examination showed the eye pigment to be located e... | 590,660 | [
0.06950268,
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0.05219111,
0.310718,
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0.03466532,
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-0.2294106,
0.3652039,
-0.08957779,
... |
Carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine and fission neutron irradiation in rats. | Examinations were made on the carcinogenic effects of a chemical compound, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and a physical carcinogen, whole-body irradiation with fission neutrons, on the gastrointestinal tract of male albino Sprague-Dawley rats. The carcinogens were used singly and together in order to inv... | 590,682 | [
-0.1019283,
0.1515168,
-0.02129845,
-0.260673,
0.223172,
-0.2472267,
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0.4771789,
0.1792885,
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0.1284437,
0.30936,
0.1936935,
0.2397599,
0.2467771,
-0.09646113,
0.17... |
Serum amylase isozymes in patients with chronic pancreatitis with hyperamylasemia. | In order to clarify the relationship between hyperamylasemia and clinical states in chronic pancreatitis, serum amylase isozymes were studied in 39 cases of chronic pancreatitis including 13 cases of alcoholic pancreatitis. Hyperamylasemia in chronic pancreatitis is generally due to high pancreatic type isoamylase (P-a... | 590,699 | [
-0.1028824,
-0.3808746,
-0.234427,
-0.03226072,
-0.2469905,
0.1794409,
-0.2983934,
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0.1646148,
0.1086409,
0.09128296,
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0.5161979,
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0.4082511,
0.1314035,
-0.3195801,
-0.00534782,
-0.1879903,
... |
Duplication cyst of the duodenum in the adult. | A duodenal duplication cyst in a 45-year-old male is reported. A hypotonic duodenography showed a smooth spherical defect in the descending portion of the duodenum. A fiberoptic duodenoscopy disclosed a smooth well-defined tumor which was located orally from the ampulla of Vater. A retrograde pancreatocholangiography i... | 590,704 | [
-0.2494624,
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0.1169888,
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0.2374716,
0.08302256,
0.4082317,
0.04418145,
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-0.5981356,
0.1455122,
0.01569295,
-0.4330105,
0.2500687,
0.003486004,
-0.0481752... |
Platelet function in fulminant hepatic failure and effect of charcoal haemoperfusion. | In 34 patients with fulminant hepatic failure, platelets, in addition to being reduced in numbers, were smaller than those of healthy controls. In keeping with this, capillary bleeding times were significantly longer than could be accounted for by reduction in numbers alone. In a small group of these patients use of ch... | 590,850 | [
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0.4030365,
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0.1195498,
0.2603401,
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0.1235416,
0.1790071,
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0.00287624,
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0.1106973,
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0.07512333,
0.05622864,
0.1031166,
0.1762218,
0.02599393,
0.01533655,
0.02939332,... |
Serum bile acids in the diagnosis of hepatobiliary disease. | The value of serum bile acids (SBA) in the diagnosis of hepatobiliary disease has been investigated. A modified GLC method was used, with an overall coefficient of variation of +/- 11% in the control range. Serum was obtained after a 12 hour fast, and two hours after a fatty meal from 73 patients and 14 control subject... | 590,851 | [
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0.04168902,
-0.4558557,
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0.08557313,
0.2071287,
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0.2379034,
0.2293665,
0.02866302,
-0.08251484,
... |
[Acute injuries to peripheral nerves. 1. Diagnosis and principles for therapy]. | A simple scheme for the identification of the most frequent lesions of single peripheral nerves is given. The scheme is based on a few--mostly two--characteristic features of each lesion. The significance of the degree of the nerve lesion for the choice of therapy is stressed. | 590,899 | [
-0.05280258,
-0.04973733,
0.09177605,
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0.02652729,
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0.2006938,
0.16317,
0.008544526,
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0.01040544,
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0.1573724,
-0.1417342,
0.3500548,
0.1669003,
-0.1721088,
0.0608849,
... |
[Community psychiatry. An empirical study]. | Aim of the present study was the analysis of the situation of fulltime and partime stationary psychiatric services, as well as clinic-administered out-patient services for a geographically defined population group in a large city (Hannover) over a period of serveral years. For this purpose an analysis was made of the c... | 590,908 | [
0.0209618,
0.1356662,
0.05438823,
0.07972357,
0.09797867,
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0.04508647,
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0.1719381,
0.001055541,
0.3421142,
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0.2866085,
0.1410774,
0.2229258,
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0.02783653,
0.2773467,
0.3965334,
-0.05131941,
... |
Hormonal regulation of the number and activity of ribosomes in mammary gland explants of mice. | Possible effects of insulin, hydrocortisone and prolactin on the number and activity of ribosomes enganged in protein biosynthesis in mammary gland explants were explored. The rate and extent of [3H]-puromycin attachment to nascent peptides was used to assess, respectively, the activity and number of ribosomes engaged ... | 590,926 | [
0.01786876,
-0.05152584,
-0.1576861,
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0.02137613,
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0.2772398,
0.2791881,
0.230723,
0.3870926,
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0.06458007,
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0.06258666,
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-0.006739735,
0.07214198,
0.5543224,
-0.2232607,
-0.059... |
Effect of CO2 on short-term human lymphocyte culture in vitro. | There was no significant difference in the mitotic indices of the cultures maintained at different CO2 concentrations, i.e. 0 percent, 5 percent and 10 percent. However, considerable variation was recorded among different individuals. | 590,972 | [
-0.06344934,
-0.2486871,
-0.2012404,
0.003347506,
0.03291827,
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-0.3116601,
0.1003585,
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0.01804106,
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0.01243425,
0.1379543,
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0.3693601,
0.09602024,
0.3158756,
0.006243468,
... |
Relationships between different functional properties of human monocytes. | Various methods for measuring monocyte numbers and function in human blood are compared. The assays used were: phagocytosis of antibody-sensitized sheep red cells; staining for diffuse non-specific esterase activity; capacity to adhere to polystyrene and ability to lyse human A1 red cells sensitized with allogeneic ant... | 591,000 | [
0.001036685,
0.1844749,
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0.0313877,
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0.009123086,
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0.2178526,
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0.2445084,
0.08888863,
0.08655041,
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0.02441218,
-0.8135511,
0.1592702,
0.1646562,
0.5020213,
0.2865053,
0.08433034,
-0.0978815... |
An unusual cause of blocked reduction of the Galeazzi injury. | Two cases of the Galeazzi lesion are described, in which a mechanical block to closed reduction of the dislocated inferior radio-ulnar joint was encountered. This does not seem to have been described before. | 591,035 | [
0.02834486,
0.398326,
-0.08977126,
-0.2135882,
-0.07978144,
-0.2274431,
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0.2542282,
0.2080567,
0.1022505,
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-0.05379473,
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-0.1735335,
0.2073006,
-0.1291022,
0.00875... |
Spontaneous rupture of the gastrocnemius muscle. | Nineteen ruptures of the medial head of the gastrocnemius muslce are described. These were caused by sudden overstretching of the muscle though concomitant ankle dorsiflexion and knee extension. Surgical exploration in 12 patients verified rupture of the musculotendinous junction. A 2-year follow-up showed that the sur... | 591,049 | [
-0.3882351,
0.2033626,
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0.002573704,
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0.07627463,
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0.1916673,
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0.06674314,
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0.407524,
-0.1176198,
-0.05... |
Effect of serum from various animal species on erythrocyte attachment of endotoxins and other bacterial antigens. | Lipopolysaccharide O antigens (endotoxins) and other bacterial antigens readily attach to erythrocytes in vitro. This attachment is prevented by certain mammalian and avian sera. In this study, the inhibitory capacity of sera from lower animals was compared with that of higher animals for a total of 30 species. Antigen... | 591,059 | [
-0.02854453,
0.2106484,
0.05608267,
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0.220516,
0.1041933,
0.08294868,
0.08724029,
0.1199975,
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0.1070654,
0.4156817,
0.2205089,
0.09639285,
-0.2925918,... |
Effects of streptolysin O on transport of amino acids, nucleosides, and glucose analogs in mammalian cells. | The transport of several amino acids, nucleosides, and glucose analogs was studies in HeLa cells treated with sublethal concentrations of streptolysin O. A differential effect of toxin on the various solutes tested was observed. The uptake of the neutral amino acids alanine, alpha-aminoisobutyric acid, leucine, and phe... | 591,062 | [
-0.0192588,
-0.2351071,
-0.4169553,
0.2342027,
0.06011434,
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0.06543393,
0.0835212,
0.1844009,
0.03820314,
0.02244908,
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0.02957767,
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0.05446459,
0.01742216,
0.02714762,
0.4989386,
0.2415311,
-0.1444797,
... |
Adherence of Veillonella species mediated by extracellular glucosyltransferase from Streptococcus salivarius. | The effect of extracellular products from Streptococcus salivarius on sucrose-dependent adherence to smooth surfaces by other oral bacteria was studied in vitro. Strains of Streptococcus mitis, Streptococcus pyogenes, and Veillonella parvula without innate ability to adhere to a steel wire were able to do so when incub... | 591,064 | [
-0.1318634,
-0.2320407,
0.1487753,
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-0.2432403,
-0.1606745,
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0.1051699,
0.1478729,
0.03036099,
-0.4881255,
-0.254476,
-0.4652341,
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0.1348682,
-0.1403444,
-0.1264928,
0.6148182,
0.3273342,
-0.09820929,... |
Decreased antibody response following immunization with enantiomorphic synthetic polypeptides. | The ability to decrease the antibody response to poly(Glu52Lys33Tyr15) in the DA and PVG strains of rats by prior immunization with its D-amino acid enantiomorph poly(DGlu48DLys38DTyr14) was tested as part of a continuing investigation into the role of optical isomerism in the ability of an antigen to induce an antibod... | 591,097 | [
-0.01609812,
-0.1658445,
-0.5691236,
-0.0368036,
0.006520309,
-0.06943016,
-0.1367493,
0.2445885,
0.1048726,
0.07670695,
0.1798922,
0.2308707,
0.09438436,
-0.1915709,
-0.133194,
-0.3775774,
-0.4908607,
0.2971731,
0.06792539,
0.3631276,
0.1234577,
0.3867517,
-0.1935958,
... |
Effect of thymectomy on lymphocyte subpopulations in the pig. Demonstration of a thymus-dependent 'null' cell. | Thymectomy in neonatal pigs results in marked lymphopenia. Surface Ig immunofluorescence, Fc rosettes and SRBC rosettes have been used to identify blood lymphocyte subpopulations. There was no marked reduction in numbers of cells in these subpopulations after thymectomy, although their proportion increased. This change... | 591,118 | [
0.3885025,
-0.4285263,
-0.04502517,
0.02916579,
0.1154539,
-0.1734083,
0.2123341,
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-0.03920037,
0.3320207,
0.211093,
0.1532106,
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0.3108932,
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-0.3770063,
-0.1539591,
0.2351345,
0.01140442,
0.2741905,
0.316903,
0.1385158,
-0.... |
A method of fitting non-symmetric Gompertz functions for characterising malignant growth. | A basic symmetrically asymptotic Gompertz equation was extended to account for more complex growth and life-table data. This extended Gompertz or non-symmetric asymptotic regression equation was found to be suitable for fitting a large variety of data exhibiting growth and experimentally-induced regression effects expr... | 591,119 | [
-0.208468,
-0.3887657,
-0.4231772,
-0.1001245,
0.2609081,
-0.3171479,
-0.2556519,
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0.06142535,
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-0.1608788,
0.1016348,
-0.2393414,
0.4579426,
-0.3455059,
-0.07009587,
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0.1296824,
-0.141764,
0.09097441,
0.3793203,
0.1767675,
-0.04276077,
0... |
Computerized EEG analysis for studying the effect of drugs on the central nervous system. | Samples of our experience in quantitative pharmaco-EEG are reviewed to discuss and define its applicability and limits. Simple processing systems, such as the computation of Hjorth's descriptors, are useful for on-line monitoring of drug-induced EEG modifications which are evident also at the visual visual analysis. Po... | 591,161 | [
0.0370414,
-0.053488,
-0.330891,
-0.3455583,
0.1863554,
-0.4066864,
-0.1033057,
-0.07645033,
-0.01441011,
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-0.0531836,
0.1049636,
0.186988,
0.09376416,
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0.02443619,
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0.5658492,
0.01435546,
0.4482477,
-0.2099369,
0.2021972,
-0.04070739,
-... |
Component activities in the autoregressive activity of physiological systems. | The higher-order autoregressive (AR) activity of a physiological system (Sato 1975a,b; Sato et al., 1977) was decomposed into first- and second-order activities. The former time-pattern displays a fast rise and an exponential decay, while the latter exhibits a damped sine wave. Application of this component analysis to... | 591,200 | [
-0.0706185,
0.0290584,
-0.3353663,
-0.01218282,
0.143785,
-0.3540503,
-0.5593626,
-0.1283965,
0.1255199,
-0.1907605,
-0.06807913,
-0.09530856,
-0.02420385,
0.1654636,
-0.4929607,
0.04754348,
-0.1467904,
0.148291,
-0.01956305,
-0.1312768,
0.1510633,
-0.05154573,
-0.1660988... |
Stabilization of flow properties of blood with phenylbenzo-gama-pyrone derivatives (flavonoids). | An investigation conducted on erythrocytes suspension in plasma revealed an instability caused by apparent sensitivity of erythrocytes to aggregation due to slight changes in normal plasma constituents. There is evidence that low level intravascular aggregation and so-called normal erythrocyte sedimentation rate (ESR) ... | 591,209 | [
0.102437,
0.2276796,
0.1439096,
-0.1493477,
0.2345375,
-0.1808368,
-0.1282745,
0.1421712,
0.0650249,
0.08042651,
0.1871224,
0.2338332,
-0.05080659,
0.1100512,
-0.7804484,
0.003649322,
-0.06717379,
0.3476015,
0.008437645,
0.5551779,
0.4036661,
0.3083149,
-0.01509234,
-0.... |
Effect of estrogen therapy on metastatic carcinoma of the prostate. | Forty-one patients with metastatic carcinoma of the prostate (stage IV) were treated with diethylstilbestrol or bilateral orchidectomy or both and followed for a period of two years. The effect of treatment was determined every six months and was based on the size and consistency of the primary lesions on rectal palpat... | 591,215 | [
0.2310775,
0.2237957,
-0.06070466,
-0.2733954,
-0.3658662,
-0.5167019,
-0.09418438,
0.1167072,
0.178737,
-0.08948234,
-0.09283922,
0.118141,
-0.1233235,
-0.07178064,
-0.5604905,
-0.1354491,
-0.2644404,
0.01819522,
0.1254752,
0.132224,
0.2760389,
0.01520093,
-0.4509713,
... |
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