title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Effects of creatinol-O-phosphate (COP) on haemodynamics and cardiac metabolism in conscious and anaesthetized dogs. | The effects of creatinol-O-phosphate (COP, Aplodan) have been studied on haemodynamics and cardiac metabolism of virtually normal heart (conscious dogs with electromagnetic probes chronically implanted) and progressively failing heart (open chest anaesthetized dogs). The results obtained show that COP in both series of... | 582,673 | [
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[On the treatment of trichonocardiosis palmellina with econazol nitrate spray (author's transl)]. | The effectiveness of econazol nitrate incorporated in spray was tested in trichonocardiosis palmellina. In all 5 cases an optimal therapeutic result was seen after a few days. | 582,687 | [
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Rociverine, a new antispasmodic agent with balanced neurotropic and myotropic activity. | A systematic study in vitro and in vivo of the antispasmodic agent 2-(diethylamino)-1-methylethyl cis-1-hydroxy (bicyclohexyl)-2-carboxylate (rociverine) showed that its activity is both antimuscarinic and directly muscle-relaxant. The antimuscarinic activity is weaker than that of atropine, N-butylscopolammonium bromi... | 582,702 | [
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Investigations on the action of cefazedone and gentamicin, alone and combined, on renal enzyme excretion in rats. | Administration of (6R, 7 R)-7-(2-[3,5-dichloro-4-oxo-1(4 H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen) in a dose of 1000 mg/kg led to a statistically significant rise of the alkaline phosphatase activity in rat... | 582,720 | [
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Clinical pharmacology phase I of cefazedone, a new cephalosporin, in healthy volunteers. II. Pharmacokinetics in comparison with cefazolin. | In two consecutive cross-over studies, each involving 10 healthy volunteers, the pharmacokinetics of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamindo)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen) in comparison with cefaz... | 582,722 | [
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[Diuretic agents in urine extracts: clearance studies, tubular glucose absorption and blood pressure]. | We previously described diuretic agents of human urine. The extracts cause a significant decrease in sodium and plasma albumin concentration in the medulla of the kidney. In the present study further investigations were performed to detect the site of action of these fractions. In the bio-assay of sodium depleted rats ... | 582,743 | [
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Treament of biguanide-induced lactic acidosis with dichloroacetate. 3 case histories. | The administration of dichloroacetate (DCA) in cases of biguanide-induced lactic acidosis (LA) improves pyruvate oxidation and therefore increases energy production from glucose. Preliminary results of treatment of LA in humans are reported. A continuous fall in pyruvate was observed in all 3 cases after administration... | 582,745 | [
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[Studies on percutaneous absorption of flumetasone pivalate and salicylic acid from a corticoid combination for topical use (author's transl)]. | The combination of 0.02% flumetasone pivalate and 1% salicylic acid in a water-alcohol solution (Locasalen) is a novel therapeutic for topical treatment of the hairy scalp and also for the cosmetically acceptable treatment of other skin areas, that is, exposed skin. An investigation was carried out in 6 patients with p... | 582,770 | [
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[Comparison of the cardiac effects of triamterene and its phase II metabolite p-hydroxytriamterene sulphuric acid ester (author's transl]. | The positive inotropic action of triamterene (TA) on isolated, electrically stimulated left atria was compared with that of its phase II metabolite, p-hydroxytriamterene sulphuric acid ester (OH-TA-ester). It was found that the metabolite also possesses a positive inotropic action, its potency, however, is about 10 tim... | 582,773 | [
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The identity and origin of oligosaccharides present in the faeces and urine of sick infants. | A systematic identification scheme, based on improved paper and thin-layer chromatography, acidic and enzymatic hydrolysis, and the reaction of carbohydrates with several location reagents, has been applied to the analysis of oligosaccharides present in the urine and faeces of sick children and the diets they are fed. ... | 582,809 | [
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[Conservative treatment of severe paralytic ileus. Clinical experiences with Ceruletid]. | After the failure of other medicamentous treatment attempts for paralytic ileus, Ceruletid (Takus) was used in 20 surgical patients. Ceruletid was applied as an infusion of 40 microgram in 250 ml or 500 ml physiological saline solution over a period of 2-3 hours. During this time the occurrence of bowel sounds, flatule... | 582,815 | [
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High-resolution real-time ultrasonography of thyroid nodules. | High-resolution real-time ultrasonography was used to evaluate 98 patients with palpable abnormalities of the thyroid and positive isotopic studies. It confirmed 37 of 73 (51%) suspected solitary nodules. Of 25 patients thought to have multinodular goiter, sonography was supportive in 21 (84%). In patients with adenoma... | 582,856 | [
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Glycosaminoglycan metabolism of the medial meniscus, the medial collateral ligament and the hip joint capsule in experimental osteoarthritis caused by immobilization of the rabbit knee. | A study was made of glycosaminoglycan metabolism in experimental osteoarthritis caused by immobilization of the rabbit knee in extension. Samples from the medial meniscus, the medial collateral ligament of the knee and the hip joint capsule were obtained and analysed after 2, 6, 10, 17, 30 and 87 days of immobilization... | 582,870 | [
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Surface carbohydrates of Rhizobium. I. Beta-1, 2-glucans. | Because of increased interest in surface carbohydrates of Rhizobium in relation to host specificity, phenol-water extractions were carried out of whole cells of Rhizobium strains of the species R. leguminosarum, R. phaseoli, R. trifolii and R. meliloti. Fractionation of the crude extracts with cetavlon afforded polysac... | 582,886 | [
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[Clinical, psychological and neurophysiological results of double-blind study on vincamine-cromesilate in patients with cerebro-vascular insufficiency (author's transl)]. | In a long-term double-blind cross-over design 26 patients with amnestic syndrome due to cerebro-vascular insufficiency were submitted to vincamine-cromesilate (Vincaryl) and placebo treatment. The efficiency of vincamine was proved by mildly ameliorated psychometric patterns, biochemically by decreased cholesterol leve... | 582,924 | [
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[Relative bioavailability of a vincamine retard formulation. Pharmacokinetic study in normal subjects (author's transl)]. | The study was carried out in 6 healthy volunteers in cross-over design. The pharmacokinetic parameters were calculated after application of 60 mg vincamine base in comparison to a sustained release formulation (vincamine ratio-pharm 30 mg) on the basis of a GC method. Summarizing it can be stated that the sustained rel... | 582,951 | [
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Hepatic microsomal mixed-function oxidase system in rats pretreated with cicloxilic acid. | In a study of the hepatic microsomal drug metabolising system in rats, pretreatment with cis-2-hydroxy-2-phenyl-cyclohexanecarboxilic acid (cicloxilic acid) did not prolong pentobarbital sleeping time or decrease the cytochrome P 450 content of the liver microsomes. The drug interacted with the liver microsomes to yiel... | 582,958 | [
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Effects of cicloxilic acid on liver subcellular fractions triglyceride content in acute ethanol intoxication. | The action of cis-2-hydroxy-2-phenyl-cyclohexanecarboxilic acid (cicloxilic acid) on the concentration of triglycerides in the subcellular compartments of the liver was investigated in acutely ethanol-intoxicated rats. Cicloxilic acid is able to significantly reduce the accumulation of neutral fats in the homogenate an... | 582,959 | [
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Effects of cicloxilic acid on secretory function of the liver. II. Effect on biliary secretion of bile acids, cholesterol and lecithin in anesthetised bileduct-cannulated rat. | cis-2-Hydroxy-2-phenyl-cyclohexanecarboxilic acid (cicloxilic acid) increases the output of bile acids and decreases that of cholesterol both in normal and in sodium taurocholate-infused rats; the biliary output of lecithin remains unchanged in normal animals but is increased in taurocholate-treated animals. The increa... | 582,963 | [
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[Antimicrobial activity of the broad spectrum antimycotic isoconazole nitrate in humans (author's transl)]. | A comparative study (occlusion test according to Marples and Kligman) was conducted in 100 test subjects with several formulations of isoconazole nitrate. The following results were obtained: 1. There are no differences in efficacy between the free base, isoconazole, and the nitrate. 2. Increasing the active substance ... | 582,987 | [
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An improvement in digoxin bioavailability. Studies with soft gelatin capsules containing a solution of digoxin. | A study of relative bioavailability of two digoxin formulations was carried out on 28 healthy volunteer human subjects of both sexes. A commercial digoxin in tablet form was compared with a new commercial formulation which contains a solution of digoxin in soft gelatin capsules. The parameters investigated were: plasma... | 582,997 | [
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Bioavailability of two tablet preparations of carbimazole in man. | 1. The bioavailability of two 5 mg tablet formulations of carbimazole (Neomercazole [A] and Carbazole [B]) have been compared in six euthyroid subjects. There was considerable inter-patient variation in absolute bioavailability although, for each subject, peak plasma concentrations of methimazole were similar with both... | 583,031 | [
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Dysthyroid ophthalmopathy: an update. | Since the original description of dysthyroid ophthalmopathy, much has been learned about its etiology, pathology, course, and management. The subject is reviewed in depth and the author suggests explanations relating to some of the poorly understood aspects of the disorder. | 583,054 | [
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[Comparative examination of endocrine ophthalmopathy by means of ultrasonography, computerized tomography and fish bioassay]. | In 35 patients with Graves' ophthalmopathy (GO) thyroid function was tested by T3-RIA, T4-RIA, TBI, TRH-test, thyroid scanning, and determination of thyroid autoantibodies. Additional ultrasonography (A-scan), computed tomography (CT) of the orbit, and the determination of an exophthalmogenic serum activity in fish bio... | 583,057 | [
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Pulmonary blastomycosis in children. Amphotericin B therapy and a review. | Two children, aged 3 months and 4 years, respectively, were treated with ten weeks of amphotericin B for culture proved pulmonary blastomycosis. Organisms were easily demonstrated in nasopharyngeal or sputum specimens on admission. Although organisms were present until the 12th and 19th days of therapy, respectively, t... | 583,093 | [
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Deuterium NMR studies of cerebroside-phospholipid bilayers. | 2H-NMR was used to probe the interaction of non-hydroxy fatty acid cerebroside and 2-hydroxy fatty acid cerebroside with the polar head group and with the acyl chains of dipalmitoylphosphatidylcholine in unsonicated bilayers. It is shown that the interior of the bilayer exhibits uniformly increasing orientational order... | 583,131 | [
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[A contribution to the stereospecific synthesis of antifungal imidazolyloxime-ethers/Oxiconazole nitrate (Sgd 301-76), a new broadspectrum antifungal agent (author's transl)]. | A stereospecific synthesis of antifungal imidazolyloxime-ether derivatives is reported. The compound Sgd 301-76 (oxiconazole nitrate) = (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-O-(2,4-dichlorobenzyl)-ethanoneoxime-nitrate was selected for clinical trials. The (E)- and (Z)-assignments, respectively, were made on ... | 583,212 | [
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[The effects of oxprenolol on cardiac function during hypovolemic shock in dogs (author's transl)]. | Effects of beta-receptor blockade by oxprenolol, which significantly prevented subendocardial necroses during hemorrhagic shock in dogs, on shock tolerance and myocardial function were analyzed. Overall mortality was not altered by beta-receptor blockade. Cardiac output and contractility (dp/dtmax) before, during and a... | 583,217 | [
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The gastrointestinal and autonomic effects of 3-methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide hydrochloride (tiquinamide). | 3-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide hydrochloride (tiquinamide), a potent gastric anti-secretory compound, affords good protection against stress- and chemically-induced gastric and duodenal erosions. It causes a dose-related delay in gastric emptying and intestinal transit, and does not have a prima... | 583,223 | [
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[Treatment of various types of hyperlipoproteinaemia with a combination of Mg-chlorophenoxy-isobutyrate and mesoinositol-hexanicotinate (author's transl)]. | 50 patients with different types of hyperlipoproteinaemia were treated with a combination of Mg-chlorophenoxyisobutyrate (700 mg) and mesoinositol-hexanicotinate (500 mg) (Atroplex) twice daily. 7 patients had type IIa, 39 patients type IIb or IV and 4 patients type V. After a period of one month without any treatment ... | 583,231 | [
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Investigation of the common mechanism of action of antibacterial compounds containing gamma-pyridone-beta-carboxylic acid structure by principal component. | On the basis of 576 in vitro antibacterial positive results of 99 compounds containing gamma-pyridone-beta-carboxylic acid structure conclusions have been drawn on the mechanism of action of the derivatives by principal component analysis. It has been found that the compounds exert their effect essentially by influenci... | 583,239 | [
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[Comparative study of relative biovailability of several spironolactone formulations in a steady-state test (author's transl)]. | By the US Food and Drug Administration spironolactone is regarded as a drug with problems related to bioavailability. A steady-state study was performed comparing the 50- and 100-mg formulations of two manufacturers with each other. Applying a fluorimetric method to both canrenone and canrenoate--the major biologically... | 583,254 | [
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Anterior orbitotomy. | A simple, safe method of treatment of the sequelae of Graves' disease involving the orbit is presented. The results in 17 cases would indicate removal of orbital fat via anterior orbitotomy is a useful adjunct in the rehabilitation of the patient with chronic ophthalmopathy. Thirty-eight cases not included in the study... | 583,296 | [
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Comparative bioavailability of a microcrystalline theophylline tablet and uncoated aminophylline tablets. | The bioavailability of a rapidly dissolving tablet of theophylline and three brands of standard aminophylline tablets was estimated in a four way cross-over study involving 8 healthy adult volunteers. The relative extent of bioavailability as assessed by the measurement of the total area under the plasma concentration ... | 583,332 | [
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Action of intracerebrally injected beta-endorphin on the rat's core temperature. | Microinjected directly into the preoptic anterior hypothalamus (POAH), beta-endorphin (0.74--7.4 nmol) induced an increase in rectal temperature (RT) in the free-moving rat. Whereas the initial phase of the endorphin-induced rise in RT was partially attenuated by naloxone (5 or 20 mg/kg i.p.) or naltrexone (3 mg/kg i.p... | 583,333 | [
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Relationship between the antitrichinellous effect of seven derivates of benzimidazolecarbamates and their chemical structure. | The efficacy of seven more recently developed anthelmintics of the benzimidazolecarbamate group, i. e., parbendazole, mebendazole, fenbendazole, oxibendazole, cambendazole, oxfendazole and albendazole, has been tested in a series of experiments on white mice artifically infected with Trichinella spiralis. Our results d... | 583,335 | [
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In vitro production of thyroid-binding antibodies by peripheral blood lymphocytes from patients with Graves' disease: nonspecific responses associated with culture supernatant proteins. | Peripheral blood lymphocytes from patients with Graves' disease were cultured for 7 days with mitogens (phytohemagglutinin, Concanavalin A, protein A), or specific antigen (thyroid membranes), in an attempt to produce thyroid-binding antibodies (TBAb) in vitro. TBAb was measured in culture supernatants using a sensitiv... | 583,343 | [
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Effects of tribenoside (Glyvenol) on experimental osteoarthrosis. | An experimental model of chemically induced osteoarthrosis in the knee joint of adult hens was used to investigate the possible anti-arthrotic potency of the D-glucofuranose derivative tribenoside (Glyvenol). Development and intensity of progressing degenerative processes in the articular tissue were controlled and qua... | 583,363 | [
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[Respiratory insufficiency in surgery]. | Acute respiratory insufficiency (ARI) (reduced PaO2 and/or increased PaCO2) in surgical patients is mostly caused by atelectasis or bronchopneumonia. These complications may develop if functional residual capacity (FRC) is reduced. Even in surgical patients with normal lungs the supine position, some pulmonary disorder... | 583,367 | [
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[Anterior sacral meningocele. Radiological study]. | The authors review the literature and report a case that illustrate the large spectrum of clinical presentation of the anterior-sacral meningocele. It is analized the presently available diagnostic procedures and it is emphasized the importance of the plain film and mielography in the correct diagnosis of this lesion. | 583,388 | [
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Anticoccidial derivatives of 6-azauracil. 2. High potency and long plasma life of N1-phenyl structures. | Attachment of substituted phenyl side chains at N1 of 6-azauracil caused striking increases in plasma life and anticoccidial potency. The increases were related in part to the acidity of the imide hydrogen. Maximum effects were shown by phenyl rings substituted in both meta positions by compact, electron-withdrawing, l... | 583,429 | [
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Protein-coated agarose surfaces for attachment of cells. | Plastic dishes were coated with an agarose layer. The layer was modified by covalently binding proteins to it, using the CNBr-method. Cells were seeded on the dishes and the number of attached cells was evaluated. The specificity of the attachment was demonstrated by showing that cells, carrying specific membrane-bound... | 583,464 | [
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[Comparative experimental animal studies of the effects of various nuclear pharmaceuticals on the EEG]. | Some of the radiopharmaceuticals presently recommended for cisternoscintigraphy were compared, in experiments on animals, for their effects upon bioelectric activity. On relaxed cats, electroencephalography did not show any effects upon bioelectric activity for 198 Au and 169 Yb Ca DTPA. One test animal each of seven a... | 583,473 | [
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Scleral buckling in 2 1/2- to 11-month-old premature infants with retinal detachment associated with acute retrolental fibroplasia. | The authors' experience over the past five years in the cryosurgical management of retinal detachment in ten eyes of eight premature infants with retrolental fibroplasia, whose ages at the time of detachment surgery ranged from 2 1/2 months to 11 months with an average of 5 1/2 months, is reported. Postoperative follow... | 583,500 | [
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Computed tomography of the orbit. | Computerized tomography (CT) has revolutionized the analysis of patients with orbital tumors. A new CT scanner devised by the author resolves structures less than 1 mm with an image section as thin as 2 mm. This improved resolution shows all the extraocular muscles, including the obliques; enlargement of the optic nerv... | 583,502 | [
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... |
Dynamic changes of horse serum T-globulin immunization with snake venoms, tetanus and diphtheria toxoids. | In course of immunizing horses with snake venoms, tetanus and diphtheria toxoids, a new serum component, T-globulin, was formed and migrated between the beta- and gamma-globulins. The T-globulin content was parallel with the antibody titre after the middle course of immunization. There were many components in snake ant... | 583,543 | [
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Insufficiency of the anterior cruciate ligament. Review of our 118 cases. | Recurrent anterior and interal rotatory subluxation of the tibial plateau is a disabling symptom in patients with insufficiency of the anterior cruciate ligament. Since 1970 we have used the N-test, a special jolt test to detect the characteristic instability. One hundred eighteen cases with anterior-internal rotatory ... | 583,559 | [
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... |
[Polymorphic histological changes in a case of angio-immunoblastic adenopathy (author's transl)]. | A patient aged 65 years was observed to have successive adenomegalic syndromes over a period of 4 years, with variable histological appearances. A right cervical adenopathy had the histological appearance of a simple antigenic-stimulation lesion. Three years later, a right inguinal adenomegaly presented all the histolo... | 583,568 | [
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[One case of primitive lymphoblastic malignant lymphoma of the appendix vermiformis (author's transl)]. | On the occasion of diagnosing one case of primitive malignant lymphoma of the appendix at the Institute of Surgical Semiology, University of Pavia, the authors discuss a number of aspects of the clinical picture, anatomopathology, and therapeutic approach to this rare malignancy. | 583,597 | [
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The effects of selected field experiences upon the drinking behavior of university students. | A study was conducted to determine the effects of selected field experiences upon the driking behavior of university students. Students in the experimental groups were required to participate in alcohol related field experiences, whereas students in the control group were not. An anonymous self-report inventory was use... | 583,783 | [
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[Family constellation in mental disorder. results and methods of statistical investigations of family size, birth order and sib position (author's transl)]. | Possibilities, difficulties and results of statistic investigations on the relation between schizophrenia, depression, neurosis and alcoholism are reported: The schizophrenic patients showed an excess of single childs and children of large sibship. In depressive patients the eldest are overrepresented. In neurotics sin... | 583,869 | [
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The effects of vasopressin on renal sodium excretion in pigs given intravascular hypertonic salt loads. | Young pigs of about 25-30 kg liveweight were given intravenous infusions of a hypertonic sodium chloride solution (4-6 mol.1(-1)) at rates varying from 2-6 mmol.min-1. Such infusions resulted in a marked increase in the urine flow and in urinary sodium excretion, the size of these increases being proportional to infusi... | 583,991 | [
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Susceptibility of three groups of Staphylococcus aureus to newer antimicrobial agents. | Because of the need for non-beta-lactam antimicrobics with antistaphylococcal activity, 14 antimicrobics (3 penicillinase-resistant penicillins, 7 aminocyclitols [5 new], 2 macrolides [1 new], clindamycin, and a new polysaccharide, everninomicin) were tested in vitro for activity against 22 penicillin-susceptible, 51 p... | 584,152 | [
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... |
Blood transfusion in children with cancer. | Blood component therapy in children with cancer continues as a major factor in all treatment programs. Current research in this area promises significant advances in the near future. Better methods of procurement, Storage, matching of donors and recipients, and investigations of granulocyte transfusions will all contri... | 584,305 | [
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Differential utility of predictors in graduate nursing education. | The problem of predicting success in graduate education in nursing was addressed through a five-year study of students enrolled in four majors at the University of Iowa. Data from a sample of 198 graduates of the majors-medical-surgical nursing, nursing of children, psychiatric nursing, and nursing service administrati... | 584,374 | [
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Inactivation of penicillin by purulent exudates. | Four of 22 specimens of human pus inactivated up to 90% of added penicillin within one hour in vitro. Ampicillin and cephaloridine were also inactivated, but streptomycin and fusidic acid were not. The effect was not related to the protein content of the pus, nor to its pH value. Microbes that may produce beta-lactamas... | 585,339 | [
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0.00... |
[Catamneses of YY carriers in prison]. | Among the 700 inmates of a big Austrian prison 5 cases of XYY caryotype were detected by means of the Quinacrinfluorescence method and subsequent lymphocyte culture. Keeping in mind that, if at all, only a small amount of criminal behavior may be explained by chromosomal factors three hypotheses about possible links be... | 585,366 | [
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[Unexplained tetraspasticity in adults (author's transl)]. | 1. Between 1965 and 1974 146 patients with unexplained tetraspasticity were admitted and examined. In 123 cases extended neuroradiologic examination with myelography of the cervical spinal canal was carried out. A space occupying lesion was found in 59 cases: narrow spinal canal, protruding discs. In 64 cases no pathol... | 585,367 | [
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Hirsutism. | Many women have some facial hair, and most patients who seek advice will be at the far end of the normal distribution curve for hair. In a second group there is a slight excessive production of androgens with associated hirsutism, either idiopathic or associated with polycystic ovarian disease. An extremely small fract... | 585,467 | [
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... |
Drug use among college students--an interim report. | A survey was conducted at Agra (India) to study the extent and pattern of the non-medical use of dependence producing drugs among the post-graduate students of the local colleges and a number of medical students of other colleges of the state of Uttar Pradesh who were posted for training at the Mental Hospital. The stu... | 585,581 | [
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[Computerized tomographic diagnosis of the brain: addition of frontal and clivo-parallel cuts to the transverse standard cuts (author's transl)]. | The data of now available transverse cut are insufficient for spatial orientation. Using a special technique, frontal and clivo-parallel cuts will provide satisfactory diagnostik detail. The often difficult differentiation between vertically adjoining or commmunicating structures will be facilitated by frontal tomograp... | 587,097 | [
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A new diabetic with complications: primary nursing care. | Martha, an elderly patient, presented a real challenge to our nursing staff. As a new diabetic, she needed a great deal of education in addition to extensive nursing care for her multiple bleeding leg ulcers, dehydration and malnutrition due to uncontrolled diabetes, and reactive depression. Despite these problems, in ... | 587,327 | [
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Diabetes management by the patient and a nurse practitioner. | Patients facing a lifelong disease condition need time and feedback from knowledgeable health professionals to achieve successful treatment compliance. Long-established behavior may need to be changed and the patient and his family need support during the process. Day-to-day problems must be viewed as important and tim... | 587,329 | [
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An eclectic approach to parent group education. | Many factors contribute to a need for parent education today. Parent education has changed over the past centuries as a result of our changing values, our increasing knowledge base, and changes in family structure. The parent education group attempts to meet the parents' need to validate their concerns and offer them p... | 587,334 | [
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Synthesis of collagen by smooth muscle in the hyertrophic intestine. | During hypertrophy of the small intestine of the guinea-pig at the oral side of an experimental stenosis, the individual intestinal segments do not increase in length but undergo a remarkable increase in weight (up to 7 times that of control segments). Concomitantly an increase in collagen content is found; this is usu... | 588,022 | [
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A congenital myopathy of unknown origin. | Parallel with the clinical and histochemical investigations, an ultrastructural examination of a muscle biopsy specimen was made, in order to detect any slight cellular alterations which cannot possibly be discovered through any other methods, and to identify a muscle disease of unknown origin. | 588,085 | [
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The invasive pituitary adenoma. A prolactin-producing tumor. | Invasive pituitary adenoma was diagnosed by means of a transnasal aspiration biopsy method in 11 patients with extensive destruction of bone in the sellar region. In most cases the initial symptoms were decrease of libido and potency or amenorrhea-galactorrhea. Later, chiasmatic compression developed in six patients, o... | 588,094 | [
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Endodontics or root canal therapy. | This article discusses the diagnosis and treatment of pulp involved teeth. There are still some patients and some older physicians who associate certain systemic diseases with dead teeth. For this reason, the subject of focal infection is considered first. As many patients with facial pain or dental infection present f... | 588,138 | [
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Social, ethnic and cultural aspects of Aboriginal health. | The current development of new trends in the delivery of health care to Aborigines prompts a review of some critical aspects of the interactions between services and clients. Private general medical practitioners are inevitably involved in these services in many areas of Australia. | 588,145 | [
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Serum-growth hormone and free-fatty-acids levels following angiocardiography in children. | Blood-free-fatty acids (F.F.A.) and growth-hormone levels were determined in 9 children subjected to cardiac catheterization and angiography. A significant rise of growth-hormone level was recorded immediately after angiocardiography, followed by a marked increase of F.F.A. levels 2--4 hours after termination of the ca... | 588,203 | [
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The isolation and further characterization of the bilirubin tetrapyrroles in bile-containing human duodenal juice and dog gall-bladder bile. | Bilirubin and its conjugates were extracted from either dog gall-bladder bile or bile-containing human duodenal juice into chloroform containing 10mm-tetraheptylammonium chloride. The intact bilirubin tetrapyrroles were then separated by t.l.c. Structural elucidation was made after coupling of the individual pigments w... | 588,243 | [
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The substrate specificity and stereochemistry, reversibility and inhibition of the 3-oxo steroid delta 4-delta 5-isomerase component of cholesterol oxidase. | 1. 5-Cholesten-3-one was shown to be an intermediate in the conversion of cholesterol into 4-cholesten-3-one by Nocardia cholesterol oxidase. 2. The absence of a C-17 side chain from 5-androstene-3,17-dione slightly increased the Vmax. of the isomerase activity relative to 5-cholesten-3-one (1.7-fold), but greatly incr... | 588,244 | [
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The involvement of the bridging imidazolate in the catalytic mechanism of action of bovine superoxide dismutase. | The pulse-radiolysis method has been used to study the catalytic mechanism of O2 leads to dismutation by the Co(II)-substituted bovine erythrocuprein (superoxide dismutase, EC 1.15.1.1). Catalysis is accompanied by spectral changes that may be interpreted in terms of rapid protonation and deprotonation of the Cu-facing... | 588,256 | [
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[Prognostic value of echography in threatened abortion]. | After a short description of the most important echographic pictures for diagnosis of spontaneous abortion in the first trimester, the clinical development in 89 patients with threatened abortion symptoms, is examined. The interruption of pregnancy has been predicted in 97,05% of the cases resulted in abortion and norm... | 588,315 | [
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[Coronary arteriovenous fistula. Considerations on differential diagnosis]. | Review is made of the literature of coronary arteriovenous fistula, since its first description up to 1975; we mention the most important points treated by each author. Two cases are studied clinically, by entheterization and coronariography. We take into consideration the differential diagnosis with patent ductus arte... | 588,338 | [
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[Familial juvenile nephronopthisis]. | For the last 20 years, 11 patients with clinicopathologic diagnosis of nephronopththisis or medullary cystic disease, have been studied at the Nephrology Department of the Hospital Infantil de México. The initial manifestations took place at ages from 3 to 12 years and consisted of polyuria and polydipsia with reductio... | 588,340 | [
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[Teaching of pediatrics within the plan of studies for general medicine (plan A-36)]. | In this article the author exposes some of the bases about the instruction program of General Integral Medicine (plan A-36); also, he compares the teaching aspects of pediatrics of this plan and the traditional plan, both carried out at the medical School of the National Autonomous University of Mexico. The author poin... | 588,343 | [
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Teeside coronary survey--fatality and comparative severity of patients treated at home, in the hospital ward, and in the coronary care unit after myocardial infarction. | An epidemiological survey of myocardial infarction in Teesside County Borough was completed between April 1972 and April 1973. Cases were notified and divided into those who had suffered a 'definite', 'possible', or 'not' myocardial infarction. Severity factors were measured in the 'definite' cases and the distribution... | 588,372 | [
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Coronary arteries in d-transposition. A necropsy study of reimplantation. | The coronary arteries are a major concern in anatomical correction of d-transposition of the great arteries. The necropsy study was undertaken to assess the feasibility of direct bilateral reimplantation as described by Fatene et al. This seemed possible in only 30 per cent of 100 cases, and furthermore was related to... | 588,379 | [
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Thermal balance during cardiopulmonary bypass with moderate hypothermia in man. | In six patients undergoing coronary vein graft operations under cardiopulmonary bypass and hypothermia, the temperatures of arterial and mixed-venous blood, nosopharynx, oesophagus, liver, rectum, deltoid and vastus lateralis muscles and 10 skin sites were recorded. Whole-body oxygen consumption was measured before coo... | 588,394 | [
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Haemodynamic responses to enflurane anaesthesia and hypovolaemia in the dog, and their modification by propranolol. | The haemodynamic responses to minimum equipotent concentrations of halothane and enflurane were compared in seven dogs. The haemodynamic responses to increasing concentrations of enflurane, and to induced hypovolaemia during enflurane anaesthesia, were studied in the same dogs, both before and after administration of p... | 588,398 | [
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0.04032832,
-0... |
Prognostic value of serum levels of immunoglobulins (IgG, IgA, IgM and IgE) in breast cancer: a preliminary study. | One hundred and sixty women admitted for breast tumour biopsy to the King's College Hospital group have been followed sequentially for 2 years. Sixty-nine women had early operable breast cancer and 91 had benign breast disease. All these women had serum immunoglobulin IgG, IgA, IgM and IgE levels measured preoperativel... | 588,419 | [
0.1172482,
-0.300318,
-0.0635881,
-0.539338,
0.009148074,
-0.5506386,
-0.06503902,
0.03973166,
-0.0831945,
0.3549697,
0.2074719,
0.1524864,
0.02380865,
0.153989,
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-0.07684543,
-0.1151109,
0.2424363,
-0.1795426,
0.05031876,
0.0328045,
-0.06006891,
... |
A pharmacological effect of oestrone on human epidermis. | Oestrone has been found to depress the incorporation of tritiated thymidine, proline and histidine in human skin in vitro. The significance of this is briefly discussed. | 588,445 | [
0.1040185,
-0.3196206,
-0.02441244,
0.1433711,
-0.06063235,
-0.06621961,
-0.207669,
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0.2341934,
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0.1558155,
0.235609,
0.1088451,
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0.04868145,
0.3134367,
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0.1046819,
0.183453,
0.3724544,
0.009567613,
-0.... |
The effects of anti-prostaglandin agents on epidermal proliferation induced by dermal inflammation. | Experimentally induced dermal inflammatory lesions cause epidermal hyperplasia and increased thymidine autoradiographic indices in the overlying epidermis. In the experiments described here anti-prostaglandin agents (indomethacin, aspirin, prednisolone and polyphloretin phosphate) were given to guinea-pigs with experim... | 588,447 | [
0.338961,
0.01270774,
-0.06632399,
0.09306145,
0.02802585,
0.09675224,
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0.04714682,
-0.1962646,
-0.2141076,
0.03010934,
0.0201712,
0.2045134,
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0.04350911,
-0.2749442,
0.1276012,
0.1347248,
0.3311127,
0.1940921,
0.03859236,
-0.4538216,
... |
The anatomical distribution of sunlight. | The relative distribution of natural ultraviolet radiation has been measured at ten sites on the surface of an unclothed manikin for 2 h around solar noon on 19 different days during late summer in Canterbury, U.K. The dosimeter used was polysulphone film. The results obtained indicate that vertical surfaces of the bod... | 588,448 | [
-0.1999653,
-0.05999381,
-0.08551782,
0.4504997,
0.1893742,
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0.07331969,
0.2224271,
0.2579975,
-0.2208995,
0.3193755,
-0.2019544,
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0.08980104,
0.1840824,
-0.09325009,
0.0006061452,
0.480708,
0.5419309,
-0.06322723,... |
Orf: a family with unusual complications. | Three members of a farming family and their local postman contracted orf. One of those affected had had no direct contact with infected sheep. Two of the family developed a widespread papulo-vesicular eruption of the skin and mucosae with pyrexia, malaise and lymphadenopathy lasting 4-5 weeks. The eruption did not rese... | 588,455 | [
-0.1420982,
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-0.05170938,
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0.09663236,
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0.2654351,
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0.00717851,
-0.3653492,
-0.03624554,
0.4579575,
-0.1052579,
0.1313896,
0.3691982,
-0.0409190... |
Haemophilia, hepatitis and porphyria. | A patient with haemophilia A developed hepatitis B, seemingly as a consequence of treatment with blood products. Six years later, bullae, photosensitivity, and the biochemical findings of porphyria cutanea tarda developed. | 588,457 | [
-0.04550078,
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0.1153326,
0.1504045,
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0.1169333,
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0.1565608,
-0.04994143,
-0.05311434,
0.2973714,
0.2549041,
-0.1330992,
... |
Onchocerciasis treated with diethylcarbamazine. | One hundred patients with onchocerciasis were treated with diethylcarbamazine: a single course of treatment led to clinical cure in 48% of the patients; no means of anticipating which patients might require only a single course of treatment was found. | 588,467 | [
-0.2295647,
0.05444815,
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0.1922278,
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-0.1982024,
0.06394018,
-0.1278509,
0.3122603,
0.13253,
0.2565389,
-0.03383837,
0... |
Transferrin uptake by rabbit alveolar macrophages in vitro. | Rabbit alveolar macrophages were shown to bind 125I-human transferrin in vitro. The binding reaction was characterized by three stages: (1) adsorption of transferrin to the cells, followed by (2) rapid uptake of the protein to reach (3) a constant level of cell-bound transferrin. The latter two stages were dependent up... | 588,476 | [
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0.17674,
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-0.07794202,
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-0.6342908,
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-0.02227617,
0.2020886,
-0.00935065,
0.4004329,
-0.1631761,... |
Quantitative determination of hippuric and m-methylhippuric acids in urine by high-speed liquid chromatography. | High-speed liquid chromatography employing an ultraviolet photometric detector has been applied to the simultaneous determination of hippuric and m-methylhippuric acids in urine. Reversed-phase partition chromatography is carried out on a muBondapak C18 column with methanol-water as the eluent system. This method obvia... | 588,487 | [
-0.2255507,
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0.2612623,
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0.01019545,
0.3158309,
0.1150314,
0.1577684,
0.1580876,
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0.5605425,
0.07031626,
0.1398145,
0.350352,
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-0.07960916,
-0.... |
Amenorrhoea and loss of weight. | Amenorrhoea due to loss of weight was diagnosed in 39 of 170 consecutively investigated patients with amenorrhoea: 24 patients had anorexia nervosa but in the remainder this diagnosis could not be made with certainty. The only difference detected between the two groups was in their lowest weights. Endocrine tests revea... | 588,489 | [
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0.2529151,
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-0.4362878,
0.07047839,
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0.07154433,
0.01079032,
0.07600264,
-0.2632973... |
A survey of amniocentesis in 925 patients at high risk of fetal genetic disorder. | Over a nine-year period, 925 pregnancies at an Israeli medical centre were selected for investigation by amniocentesis for genetic reasons. In only 30 pregnancies did failure of laboratory methods or difficulty with amniocentesis lead to a lack of results with which to assess the normality of the fetus. The information... | 588,490 | [
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0.0812428,
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0.3273778,
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0.04039157,
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0.005859665,
0.4346783,
0.07588066,
0.04574364,... |
Plasma urate and serum deoxycytidylate deaminase measurements for the early diagnosis of pre-eclampsia. | The value of measuring plasma urate and serum deoxycytidylate deaminase (dCMP deaminase) for the early diagnosis of pre-eclampsia has been investigated in 45 patients. A combination of increased blood pressure and increased plasma urate identified 19 patients with a high incidence of fetal and maternal morbidity ascrib... | 588,501 | [
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0.3622492,
0.05837215,
0.4341758,
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0.3468587,
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0.1445556,
-0.2078544,
0.1053732,
0.279346,
0.3370586,
-0.1892806,
0.203... |
Sequential studies in pre-eclampsia using plasma fibrinogen chromatography. | The technique of plasma fibrinogen chromatography was used to study sequential changes in coagulant and fibrinolytic activity in six patients with severe pre-eclampsia. Plasma soluble fibrinogen-fibrin complex and plasma fibrinogen-fibrin degradation product levels were measured as indices of coagulant and fibrinolytic... | 588,502 | [
-0.06907528,
0.2318973,
-0.2523779,
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0.3735793,
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-0.03994486,
0.2014479,
-0.04868177,
-0.1380329,
-0.005540189,
0.04096748,
0.06634045,
0.02556223,
-0.3359687,
0.08497368,
-0.02795404,
0.2101527,
0.1075007,
0.2185,
-0.0590705,... |
Outflow changes in positive provocative tests. | The outflow changes in 26 eyes were measured during the course of a positive provocative test with pilocarpine and phenylephrine. Three separate patterns of response occurred: (1) One dose of pilocarpine and phenylephrine produced an acute attack with a large reduction in outflow. (2) The first dose of pilocarpine and ... | 588,514 | [
-0.2289981,
-0.1388938,
-0.4854067,
-0.2874714,
-0.03187139,
-0.379785,
-0.3066779,
-0.008943722,
0.05025376,
-0.09137604,
0.008571032,
-0.00006068849,
-0.1864465,
0.04875434,
-0.2132937,
-0.08770596,
-0.270474,
0.07905935,
-0.2450884,
-0.02048522,
0.09984542,
-0.09195226,
... |
Circulating lipoprotein and blood glucose levels in association with low-tension and chronic simple glaucoma. | Circulating lipoprotein and blood glucose levels were determined for 53 patients with low-tension glaucoma and 39 patients with chronic simple glaucoma. The incidence of hypercholesterolaemia was significantly higher in the low-tension group than in the chronic simple glaucoma group and control data obtained elsewhere.... | 588,516 | [
0.02352474,
0.2981602,
-0.1015336,
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0.1419777,
0.2227217,
-0.147446,
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0.1924213,
-0.04223919,
0.1108517,
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-0.3433595,
0.1393344,
0.03563271,
0.1419904,
-0.1262472,
0.2132532,
-0.1666613,
... |
Bull's eye maculopathy with early cone degeneration. | Seven patients with acquired cone degeneration were investigated. The initial visual acuities in 6 of the series were normal or near normal but later deteriorated, although they did not fall below 6/60 in any patient. All the patients tested had colour vision defects and abnormalities on electrodiagnostic testing refer... | 588,526 | [
-0.1096966,
-0.08702894,
-0.1682457,
-0.03682867,
0.1897874,
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0.00728638,
-0.01690173,
0.2330867,
0.1959587,
-0.00578344,
-0.03009139,
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-0.5813454,
0.4637037,
0.07055356,
-0.5341821,
0.2075532,
0.3104984,
0.158769... |
The effects of pregnancy and lactation on copper and zinc retention in the rat. | 1. The accretion of copper and zinc in maternal tissues, conception products and postnatal offspring of the rat was determined at different stages of pregnancy and lactation. 2. Equations relating the weight of the bodies of the developing young and of the amounts of Cu and Zn in them to the time that has elapsed since... | 588,538 | [
-0.01574493,
-0.06399716,
-0.3502684,
-0.1377897,
0.2365521,
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-0.229804,
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0.08608902,
0.4144556,
0.09287093,
-0.02801396,
0.136456,
0.1328837,
-0.3998686,
-0.201087,
-0.03601234,
0.1470764,
0.06510748,
-0.1480135,
0.2330403,
0.3642143,
-0.04810409,
... |
The effects on glucose metabolism of feeding a high-urea diet to sheep. | 1. Sheep were given either a basal diet of 107 g crude protein (nitrogen X 6.25)/kg or the same diet to which urea was added to increase the crude protein content to 221 g/kg. Isotope-dilution techniques with [U-14C]glucose and [2-3H]glucose were used to measure various criteria of glucose metabolism. The plasma concen... | 588,543 | [
-0.1897746,
-0.03633812,
-0.08627164,
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0.2560615,
-0.2323006,
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0.08291889,
-0.1008384,
-0.09254348,
-0.05624174,
0.0435793,
0.1060577,
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-0.2236817,
0.2918909,
-0.06832631,
-0.15067,
0.09301847,
0.2283448,
0.1055... |
Fatty acid synthesis and metabolism of phospholipid acyl groups in strain L mouse fibroblasts. | Strain L mouse fibroblasts grown in medium supplemented with 2.5% delipidized horse serum were found capable of desaturating oleic and linoleic acid to dienoic and trienoic acid(s), respectively. Although 40-60% of de novo fatty acid synthesis from [2-3H]acetate was inhibited by the administration of exogenous oleic or... | 588,578 | [
-0.4302073,
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0.02087564,
0.2913298,
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0.006800644,
0.4434786,
0.157399,
-0.1348281,
-0.04964039,
-0.1865912,
0.07941787,
0.1288225,
-0.3172148,
0.04271296,
-0.3785771,
-0.1970978,
-0.2348137,
0.07382546,
-0.05074301,
0.4101731,
-0.489460... |
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